CINXE.COM

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>Search results for: Fadia Najjar</title> <meta name="description" content="Search results for: Fadia Najjar"> <meta name="keywords" content="Fadia Najjar"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Fadia Najjar" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/committees" rel="nofollow">Committees</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownPublications" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Publications </a> <div class="dropdown-menu" aria-labelledby="navbarDropdownPublications"> <a class="dropdown-item" href="https://publications.waset.org/abstracts">Abstracts</a> <a class="dropdown-item" href="https://publications.waset.org">Periodicals</a> <a class="dropdown-item" href="https://publications.waset.org/archive">Archive</a> </div> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/page/support" title="Support">Support</a> </li> </ul> </div> </div> </nav> </div> </header> <main> <div class="container mt-4"> <div class="row"> <div class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Fadia Najjar"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 16</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Fadia Najjar</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Focalization Used as a Narrative Strategy Mirroring Fadia Faqir’s Ideology in Pillars of Salt 1996</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Malika%20Hammouche">Malika Hammouche </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The novel Pillars of Salt, written by Fadia Faqir in 1996, is a good example where storytelling is utilized as a traditional material to underline the author’s womanist ideology. A study of narrative could be fruitfully combined with that of ideology in this case. This combination could be demonstrated through the narrative technique used by Fadia Faqir in Pillars of Salt (1996), reflecting her anti-colonial ideology. The first step of this work will highlight the storyteller’s narrative in the novel representing, on the one hand, the imperial voice, and on the other exoticism and orientalism. The second step will demonstrate how Faqir’s narrative technique uses focalization as a narratological tool to negotiate her space. Faqir gives a voice to the female protagonist of the novel within the androcentric bias of Arab narrative theory to point to and amend the orientalist discourse typical to colonial literature. The orientalist discourse is represented through the voice of the storyteller in the novel. The juxtaposition of the storyteller’s and the female protagonist narratives is borrowed from the Arab literary background. It is a postcolonial counter-discursive strategy used by the author as a traditional material to underline her Arabo Islamic Womanist ideology in this novel. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arabo%20Islamic%20womanism" title="Arabo Islamic womanism">Arabo Islamic womanism</a>, <a href="https://publications.waset.org/abstracts/search?q=focalization" title=" focalization"> focalization</a>, <a href="https://publications.waset.org/abstracts/search?q=ideology" title=" ideology"> ideology</a>, <a href="https://publications.waset.org/abstracts/search?q=narrative%20technique" title=" narrative technique"> narrative technique</a>, <a href="https://publications.waset.org/abstracts/search?q=orientalist" title=" orientalist"> orientalist</a> </p> <a href="https://publications.waset.org/abstracts/109968/focalization-used-as-a-narrative-strategy-mirroring-fadia-faqirs-ideology-in-pillars-of-salt-1996" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/109968.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">240</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> A Ferutinin Analogue with Enhanced Potency and Selectivity against Estrogen Receptor Positive Breast Cancer Cells in vitro</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Remi%20Safi">Remi Safi</a>, <a href="https://publications.waset.org/abstracts/search?q=Aline%20Hamade"> Aline Hamade</a>, <a href="https://publications.waset.org/abstracts/search?q=Najat%20Bteich"> Najat Bteich</a>, <a href="https://publications.waset.org/abstracts/search?q=Jamal%20El%20Saghir"> Jamal El Saghir</a>, <a href="https://publications.waset.org/abstracts/search?q=Mona%20Diab%20Assaf"> Mona Diab Assaf</a>, <a href="https://publications.waset.org/abstracts/search?q=Marwan%20El-Sabban"> Marwan El-Sabban</a>, <a href="https://publications.waset.org/abstracts/search?q=Fadia%20Najjar"> Fadia Najjar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Estrogen is considered a risk factor for breast cancer since it promotes breast-cell proliferation. The jaesckeanadiol-3-p-hydroxyphenylpropanoate, a hemi-synthetic analogue of the natural phytoestrogen ferutinin (jaesckeanadiol-p-hydroxybenzoate), is designed to be devoid of estrogenic activity. This analogue induces a cytotoxic effect 30 times higher than that of ferutinin towards MCF-7 breast cancer cell line. We compared these two compounds with respect to their effect on proliferation, cell cycle distribution and cancer stem-like cells in the MCF-7 cell line. Treatment with ferutinin (30 μM) and its analogue (1 μM) produced a significant accumulation of cells at the pre G0/G1 cell cycle phase and triggered apoptosis. Importantly, this compound retains its anti-proliferative activity against breast cancer stem/progenitor cells that are naturally insensitive to ferutinin at the same dose. These results position ferutinin analogue as an effective compound inhibiting the proliferation of estrogen-dependent breast cancer cells and consistently targeting their stem-like cells. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ferutinin" title="ferutinin">ferutinin</a>, <a href="https://publications.waset.org/abstracts/search?q=hemi-synthetic%20analogue" title=" hemi-synthetic analogue"> hemi-synthetic analogue</a>, <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title=" breast cancer"> breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=estrogen" title=" estrogen"> estrogen</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%2Fprogenitor%20cells" title=" stem/progenitor cells"> stem/progenitor cells</a> </p> <a href="https://publications.waset.org/abstracts/98903/a-ferutinin-analogue-with-enhanced-potency-and-selectivity-against-estrogen-receptor-positive-breast-cancer-cells-in-vitro" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/98903.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">189</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Implementation of a Baseline RISC for the Realization of a Dynamically Reconfigurable Processor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hajer%20Najjar">Hajer Najjar</a>, <a href="https://publications.waset.org/abstracts/search?q=Riad%20Bourguiba"> Riad Bourguiba</a>, <a href="https://publications.waset.org/abstracts/search?q=Jaouhar%20Mouine"> Jaouhar Mouine</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Reduced instruction set computer (RISC) processors are widely used because of their multiple advantages. In fact, they are based on a simple instruction set so that they increase the speed of the processor and reduce its energy consumption. In this paper, we will present a basic RISC architecture processor that will be developed later to converge to a new architecture with runtime reconfiguration. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=processor" title="processor">processor</a>, <a href="https://publications.waset.org/abstracts/search?q=RISC" title=" RISC"> RISC</a>, <a href="https://publications.waset.org/abstracts/search?q=DLX" title=" DLX"> DLX</a>, <a href="https://publications.waset.org/abstracts/search?q=pipeline" title=" pipeline"> pipeline</a>, <a href="https://publications.waset.org/abstracts/search?q=runtime%20reconfiguration" title=" runtime reconfiguration"> runtime reconfiguration</a> </p> <a href="https://publications.waset.org/abstracts/16176/implementation-of-a-baseline-risc-for-the-realization-of-a-dynamically-reconfigurable-processor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16176.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">405</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> Probabilistic Analysis of Fiber-Reinforced Infinite Slopes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Assile%20Abou%20Diab">Assile Abou Diab</a>, <a href="https://publications.waset.org/abstracts/search?q=Shadi%20Najjar"> Shadi Najjar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fiber-reinforcement is an effective soil improvement technique for applications involving the prevention of shallow failures on the slope face and the repair of existing slope failures. A typical application is the stabilization of cohesionless infinite slopes. The objective of this paper is to present a probabilistic, reliability-based methodology (based on Monte Carlo simulations) for the design of a practical fiber-reinforced cohesionless infinite slope, taking into consideration the impact of various sources of uncertainty. Recommendations are made regarding the required factors of safety that need to be used to achieve a given target reliability level. These factors of safety could differ from the traditional deterministic factor of safety. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=factor%20of%20safety" title="factor of safety">factor of safety</a>, <a href="https://publications.waset.org/abstracts/search?q=fiber%20reinforcement" title=" fiber reinforcement"> fiber reinforcement</a>, <a href="https://publications.waset.org/abstracts/search?q=infinite%20slope" title=" infinite slope"> infinite slope</a>, <a href="https://publications.waset.org/abstracts/search?q=reliability-based%20design" title=" reliability-based design"> reliability-based design</a>, <a href="https://publications.waset.org/abstracts/search?q=uncertainty" title=" uncertainty"> uncertainty</a> </p> <a href="https://publications.waset.org/abstracts/75670/probabilistic-analysis-of-fiber-reinforced-infinite-slopes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75670.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">365</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Genetic and Non-Genetic Evaluation of Milk Yield and Litter Size of Awassi Sheep in Drylands</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khaled%20Al-Najjar">Khaled Al-Najjar</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmad%20Q.%20Al-Momani"> Ahmad Q. Al-Momani</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Elnahas"> Ahmed Elnahas</a>, <a href="https://publications.waset.org/abstracts/search?q=Reda%20Elsaid"> Reda Elsaid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The research was carried out using records of Awassi sheep bred in drylands at Al-Fjaj Station, Jordan. That aimed to study non-genetic factors affecting milk yield (MK), litter size at birth (LZB); estimate heritability, repeatability, and genetic and phenotypic correlation using SAS and MTDFREML programs. The results were as follows, the average MK and LZB were 92.84 (kg) and 1.16, respectively. MK was highly significantly affected by each parity, age of ewe, year of lambing, and lactation period, while only the year of lambing had a significant effect on LZB. The heritability and repeatability were 0.07 and 0.10 for MK, while it was 0.05 and 0.25 for LZB. The genetic and phenotypic correlations were 0.17 and 0.02 between MK and LZB, respectively. The research concluded that the herd is genetically homozygous and therefore needs to increase genetic variance by introducing LZB-improved rams and selecting females from dams who achieved at least four parties to increase returns in drylands. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Awassi%20sheep" title="Awassi sheep">Awassi sheep</a>, <a href="https://publications.waset.org/abstracts/search?q=genetic%20parameters" title=" genetic parameters"> genetic parameters</a>, <a href="https://publications.waset.org/abstracts/search?q=litter%20size" title=" litter size"> litter size</a>, <a href="https://publications.waset.org/abstracts/search?q=milk%20yield" title=" milk yield"> milk yield</a> </p> <a href="https://publications.waset.org/abstracts/149418/genetic-and-non-genetic-evaluation-of-milk-yield-and-litter-size-of-awassi-sheep-in-drylands" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/149418.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">121</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> A Pragmatic Reading of the Verb "Kana" and Its Meanings</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Manal%20M.%20H.%20Said%20Najjar">Manal M. H. Said Najjar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Arab Grammarians stood at variance with regard to the definition of kana (which might equal was, were, the past form of “be” in English). Kana was considered as a verb, a particle, or a quasi-verb by different scholars; others saw it as an auxiliary verb; while some other scholars categorized kana as one of the incomplete verbs or (Afa’al naqisa) based on two different claims: first, a considerable group of grammarians saw kana as fie’l naqis or an incomplete verb since it indicates time, but not the event or action itself. Second, kana requires a predicate (xabar) to complete the meaning, i.e., it does not suffice itself with a noun in the nominal sentence. This study argues that categorizing the verb kana as fie’l naqis or an incomplete verb is inaccurate and confusing since the term “incomplete” does not agree with its characteristics, meanings, and temporal indications. Moreover, interpreting kana as a past verb is also inaccurate. kana كان (derived from the absolute action of being كون) is considered unique and the most comprehensive verb, encompassing all tenses of the past, present, and future within the dimensions of continuity and eternity of all possible actions under “being”. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pragmatics" title="pragmatics">pragmatics</a>, <a href="https://publications.waset.org/abstracts/search?q=kana" title=" kana"> kana</a>, <a href="https://publications.waset.org/abstracts/search?q=context" title=" context"> context</a>, <a href="https://publications.waset.org/abstracts/search?q=Arab%20grammarians" title=" Arab grammarians"> Arab grammarians</a>, <a href="https://publications.waset.org/abstracts/search?q=meaning" title=" meaning"> meaning</a>, <a href="https://publications.waset.org/abstracts/search?q=fie%E2%80%99l%20naqis" title=" fie’l naqis"> fie’l naqis</a> </p> <a href="https://publications.waset.org/abstracts/153560/a-pragmatic-reading-of-the-verb-kana-and-its-meanings" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/153560.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">94</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Alienation in Somecontemporary Anglo Arab Novels</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Atef%20Abdallah%20Abouelmaaty">Atef Abdallah Abouelmaaty</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this paper is to study the theme of alienation in some contemporary novels of the most prominent Arab writers who live in Britain and write in English. The paper will focus on three female novelists of Arab origins who won wide fame among reading public, and also won international prizes for their literary creation. The first is the Egyptian Ahdaf Soueif(born in 1950) whose novel The Map of Love(1999) was shortlisted for the Man Booker Prize, and has been translated into twenty one languages and sold over a million copies. The second is the Jordanian Fadia Faqir (born in 1956) whose My Name is Salma(2007) was translated into thirteen languages, and was a runner up for the ALOA literary prize. The third is the Sudanese Leila Aboulela(born in 1964) who The Translator was nominated for the Orange Prize and was chosen as a a notable book of the year by the New York Times in 2006. The main reason of choosing the theme of alienation is that it is the qualifying feature of the above mentioned novels. This is because the theme is clearly projected and we can see different kinds of alienation: alienation of man from himself, alienation of man from other men, and alienation of man from society. The paper is concerned with studying this central theme together with its different forms. Moreover, the paper will try to identify the main causes of this alienation among which are frustrated love, the failure to adjust to change, and ethnic pride. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alienation" title="alienation">alienation</a>, <a href="https://publications.waset.org/abstracts/search?q=Anglo-Arab" title=" Anglo-Arab"> Anglo-Arab</a>, <a href="https://publications.waset.org/abstracts/search?q=contemporary" title=" contemporary"> contemporary</a>, <a href="https://publications.waset.org/abstracts/search?q=novels" title=" novels"> novels</a> </p> <a href="https://publications.waset.org/abstracts/37970/alienation-in-somecontemporary-anglo-arab-novels" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37970.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">439</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> An Assessment of the Temperature Change Scenarios Using RS and GIS Techniques: A Case Study of Sindh</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jan%20Muhammad">Jan Muhammad</a>, <a href="https://publications.waset.org/abstracts/search?q=Saad%20Malik"> Saad Malik</a>, <a href="https://publications.waset.org/abstracts/search?q=Fadia%20W.%20Al-Azawi"> Fadia W. Al-Azawi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Imran"> Ali Imran</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the era of climate variability, rising temperatures are the most significant aspect. In this study PRECIS model data and observed data are used for assessing the temperature change scenarios of Sindh province during the first half of present century. Observed data from various meteorological stations of Sindh are the primary source for temperature change detection. The current scenario (1961–1990) and the future one (2010-2050) are acted by the PRECIS Regional Climate Model at a spatial resolution of 25 * 25 km. Regional Climate Model (RCM) can yield reasonably suitable projections to be used for climate-scenario. The main objective of the study is to map the simulated temperature as obtained from climate model-PRECIS and their comparison with observed temperatures. The analysis is done on all the districts of Sindh in order to have a more precise picture of temperature change scenarios. According to results the temperature is likely to increases by 1.5 - 2.1°C by 2050, compared to the baseline temperature of 1961-1990. The model assesses more accurate values in northern districts of Sindh as compared to the coastal belt of Sindh. All the district of the Sindh province exhibit an increasing trend in the mean temperature scenarios and each decade seems to be warmer than the previous one. An understanding of the change in temperatures is very vital for various sectors such as weather forecasting, water, agriculture, and health, etc. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=PRECIS%20Model" title="PRECIS Model">PRECIS Model</a>, <a href="https://publications.waset.org/abstracts/search?q=real%20observed%20data" title=" real observed data"> real observed data</a>, <a href="https://publications.waset.org/abstracts/search?q=Arc%20GIS" title=" Arc GIS"> Arc GIS</a>, <a href="https://publications.waset.org/abstracts/search?q=interpolation%20techniques" title=" interpolation techniques"> interpolation techniques</a> </p> <a href="https://publications.waset.org/abstracts/58914/an-assessment-of-the-temperature-change-scenarios-using-rs-and-gis-techniques-a-case-study-of-sindh" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/58914.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">249</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Theoretical Investigation of the Singlet and Triplet Electronic States of ⁹⁰ZrS Molecules</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Makhlouf%20Sandy">Makhlouf Sandy</a>, <a href="https://publications.waset.org/abstracts/search?q=Adem%20Ziad"> Adem Ziad</a>, <a href="https://publications.waset.org/abstracts/search?q=Taher%20Fadia"> Taher Fadia</a>, <a href="https://publications.waset.org/abstracts/search?q=Magnier%20Sylvie"> Magnier Sylvie </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The electronic structure of 90ZrS has been investigated using Ab-initio methods based on Complete Active Space Self Consistent Field and Multi-reference Configuration Interaction (CASSCF/MRCI). The number of predicted states has been extended to 14 singlet and 12 triplet lowest-lying states situated below 36000cm-1. The equilibrium energies of these 26 lowest-lying electronic states have been calculated in the 2S+1Λ(±) representation. The potential energy curves have been plotted in function of the inter-nuclear distances in a range of 1.5 to 4.5Å. Spectroscopic constants, permanent electric dipole moments and transition dipole moments between the different electronic states have also been determined. A discrepancy error of utmost 5% for the majority of values shows a good agreement with available experimental data. The ground state is found to be of symmetry X1Σ+ with an equilibrium inter-nuclear distance Re= 2.16Å. However, the (1)3Δ is the closest state to X1Σ+ and is situated at 514 cm-1. To the best of our knowledge, this is the first time that the spin-orbit coupling has been investigated for all the predicted states of ZrS. 52 electronic components in the Ω(±) representation have been predicted. The energies of these components, the spectroscopic constants ωe, ωeχe, βe and the equilibrium inter-nuclear distances have been also obtained. The percentage composition of the Ω state wave-functions in terms of S-Λ states was calculated to identify their corresponding main parents. These (SOC) calculations have determined the shift between (1)3Δ1 and X1Σ+ states and confirmed the ground state type being 1Σ+. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CASSCF%2FMRCI" title="CASSCF/MRCI">CASSCF/MRCI</a>, <a href="https://publications.waset.org/abstracts/search?q=electronic%20structure" title=" electronic structure"> electronic structure</a>, <a href="https://publications.waset.org/abstracts/search?q=spin-orbit%20effect" title=" spin-orbit effect"> spin-orbit effect</a>, <a href="https://publications.waset.org/abstracts/search?q=zirconium%20monosulfide" title=" zirconium monosulfide"> zirconium monosulfide</a> </p> <a href="https://publications.waset.org/abstracts/94711/theoretical-investigation-of-the-singlet-and-triplet-electronic-states-of-9zrs-molecules" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/94711.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">168</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Competitive Adsorption of Heavy Metals onto Natural and Activated Clay: Equilibrium, Kinetics and Modeling</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=L.%20Khalfa">L. Khalfa</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Bagane"> M. Bagane</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20L.%20Cervera"> M. L. Cervera</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Najjar"> S. Najjar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this work is to present a low cost adsorbent for removing toxic heavy metals from aqueous solutions. Therefore, we are interested to investigate the efficiency of natural clay minerals collected from south Tunisia and their modified form using sulfuric acid in the removal of toxic metal ions: Zn(II) and Pb(II) from synthetic waste water solutions. The obtained results indicate that metal uptake is pH-dependent and maximum removal was detected to occur at pH 6. Adsorption equilibrium is very rapid and it was achieved after 90 min for both metal ions studied. The kinetics results show that the pseudo-second-order model describes the adsorption and the intraparticle diffusion models are the limiting step. The treatment of natural clay with sulfuric acid creates more active sites and increases the surface area, so it showed an increase of the adsorbed quantities of lead and zinc in single and binary systems. The competitive adsorption study showed that the uptake of lead was inhibited in the presence of 10 mg/L of zinc. An antagonistic binary adsorption mechanism was observed. These results revealed that clay is an effective natural material for removing lead and zinc in single and binary systems from aqueous solution. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heavy%20metal" title="heavy metal">heavy metal</a>, <a href="https://publications.waset.org/abstracts/search?q=activated%20clay" title=" activated clay"> activated clay</a>, <a href="https://publications.waset.org/abstracts/search?q=kinetic%20study" title=" kinetic study"> kinetic study</a>, <a href="https://publications.waset.org/abstracts/search?q=competitive%20adsorption" title=" competitive adsorption"> competitive adsorption</a>, <a href="https://publications.waset.org/abstracts/search?q=modeling" title=" modeling"> modeling</a> </p> <a href="https://publications.waset.org/abstracts/48926/competitive-adsorption-of-heavy-metals-onto-natural-and-activated-clay-equilibrium-kinetics-and-modeling" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/48926.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">222</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Reliability Based Analysis of Multi-Lane Reinforced Concrete Slab Bridges</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ali%20Mahmoud">Ali Mahmoud</a>, <a href="https://publications.waset.org/abstracts/search?q=Shadi%20Najjar"> Shadi Najjar</a>, <a href="https://publications.waset.org/abstracts/search?q=Mounir%20Mabsout"> Mounir Mabsout</a>, <a href="https://publications.waset.org/abstracts/search?q=Kassim%20Tarhini"> Kassim Tarhini</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Empirical expressions for estimating the wheel load distribution and live-load bending moment are typically specified in highway bridge codes such as the AASHTO procedures. The purpose of this paper is to analyze the reliability levels that are inherent in reinforced concrete slab bridges that are designed based on the simplified empirical live load equations in the AASHTO LRFD procedures. To achieve this objective, bridges with multi-lanes (three and four lanes) and different spans are modeled using finite-element analysis (FEA) subjected to HS20 truck loading, tandem loading, and standard lane loading per AASHTO LRFD procedures. The FEA results are compared with the AASHTO LRFD moments in order to quantify the biases that might result from the simplifying assumptions adopted in AASHTO. A reliability analysis is conducted to quantify the reliability index for bridges designed using AASHTO procedures. To reach a consistent level of safety for three- and four-lane bridges, following a previous study restricted to one- and two-lane bridges, the live load factor in the design equation proposed by AASHTO LRFD will be assessed and revised if needed by alternating the live load factor for these lanes. The results will provide structural engineers with more consistent provisions to design concrete slab bridges or evaluate the load-carrying capacity of existing bridges. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=reliability%20analysis%20of%20concrete%20bridges" title="reliability analysis of concrete bridges">reliability analysis of concrete bridges</a>, <a href="https://publications.waset.org/abstracts/search?q=finite%20element%20modeling" title=" finite element modeling"> finite element modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=reliability%20analysis" title=" reliability analysis"> reliability analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=reinforced%20concrete%20bridge%20design" title=" reinforced concrete bridge design"> reinforced concrete bridge design</a>, <a href="https://publications.waset.org/abstracts/search?q=load%20carrying%20capacity" title=" load carrying capacity"> load carrying capacity</a> </p> <a href="https://publications.waset.org/abstracts/73454/reliability-based-analysis-of-multi-lane-reinforced-concrete-slab-bridges" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/73454.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">340</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Assessment of Predictive Confounders for the Prevalence of Breast Cancer among Iraqi Population: A Retrospective Study from Baghdad, Iraq </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nadia%20H.%20Mohammed">Nadia H. Mohammed</a>, <a href="https://publications.waset.org/abstracts/search?q=Anmar%20Al-Taie"> Anmar Al-Taie</a>, <a href="https://publications.waset.org/abstracts/search?q=Fadia%20H.%20Al-Sultany"> Fadia H. Al-Sultany</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Although breast cancer prevalence continues to increase, mortality has been decreasing as a result of early detection and improvement in adjuvant systemic therapy. Nevertheless, this disease required further efforts to understand and identify the associated potential risk factors that could play a role in the prevalence of this malignancy among Iraqi women. The objective of this study was to assess the perception of certain predictive risk factors on the prevalence of breast cancer types among a sample of Iraqi women diagnosed with breast cancer. This was a retrospective observational study carried out at National Cancer Research Center in College of Medicine, Baghdad University from November 2017 to January 2018. Data of 100 patients with breast cancer whose biopsies examined in the National Cancer Research Center were included in this study. Data were collected to structure a detailed assessment regarding the patients’ demographic, medical and cancer records. The majority of study participants (94%) suffered from ductal breast cancer with mean age 49.57 years. Among those women, 48.9% were obese with body mass index (BMI) 35 kg/m<sup>2</sup>. 68.1% of them had positive family history of breast cancer and 66% had low parity. 40.4% had stage II ductal breast cancer followed by 25.5% with stage III. It was found that 59.6% and 68.1% had positive oestrogen receptor sensitivity and positive human epidermal growth factor (HER2/neu) receptor sensitivity respectively. In regard to the impact of prediction of certain variables on the incidence of ductal breast cancer, positive family history of breast cancer (P < 0.0001), low parity (P< 0.0001), stage I and II breast cancer (P = 0.02) and positive HER2/neu status (P < 0.0001) were significant predictive factors among the study participants. The results from this study provide relevant evidence for a significant positive and potential association between certain risk factors and the prevalence of breast cancer among Iraqi women. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ductal%20Breast%20Cancer" title="Ductal Breast Cancer">Ductal Breast Cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=Hormone%20Sensitivity" title=" Hormone Sensitivity"> Hormone Sensitivity</a>, <a href="https://publications.waset.org/abstracts/search?q=Iraq" title=" Iraq"> Iraq</a>, <a href="https://publications.waset.org/abstracts/search?q=Risk%20Factors" title=" Risk Factors"> Risk Factors</a> </p> <a href="https://publications.waset.org/abstracts/106915/assessment-of-predictive-confounders-for-the-prevalence-of-breast-cancer-among-iraqi-population-a-retrospective-study-from-baghdad-iraq" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/106915.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">128</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> The Redundant Kana: A Pragmatic Reading</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Manal%20%20Mohammed%20Hisham%20Said%20Najjar">Manal Mohammed Hisham Said Najjar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Arab Grammarians shed light on the redundant kana (was) and gave it a considerable attention. However, their considerations and interpretations pertaining to using this verb varied: is it used to determine tense? Or used for further emphasis or for another function? Does it have a syntactic function? Morphologically, could it be used in other forms than the past? In addition, Arab Grammarians discussed the possibility of using kana to locate itself in between the syntactic constructs of a sentence, a phrase, or a collocation. Others questioned its position whether it is in initial or final. This study found out that the redundant kana (was) is cited in Quran and was used by the Arabs in their speech and poetry. This redundant kana, whether used in initial position or in a final position, or in between the constructs of a sentence, a phrase, or a collocation, implies pragmatic meanings intended by the speaker or the poet to serve different functions, such as to indicate the past tense, to provide emphasis, and to refer to the continuity of the effect and meaning of a verb or adjective. The study concludes that this verb kana can be utilized in different contexts to achieve a specific effect as did the old Arabs who used it to add specific shades of meanings. Kana as a redundant word could be added to further highlight the meaning aimed at in a specific utterance. In addition, this verb can be used in both the past and the present morphological form; and its availability in an utterance could be functional and could not be. In other words, the study found out that the redundant kana can be used in various positions in an utterance, initial, final, or in between a syntactic structure, provided that this use is pragmatically functional. In conclusion, this paper seeks to invite the scholars of the Arabic language to coin a new term which is the “pragmatic kana” to replace the term “kana alzae’da (redundant kana)” which might mean that its use is redundant and void of significance – a fact that is illogical due to its recurrent use in the Holy Quran. NOTE: Please take this study not the other one (sent by mistake) and titled kana alnaqisa <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=redundan" title="redundan">redundan</a>, <a href="https://publications.waset.org/abstracts/search?q=kana" title=" kana"> kana</a>, <a href="https://publications.waset.org/abstracts/search?q=grammarians" title=" grammarians"> grammarians</a>, <a href="https://publications.waset.org/abstracts/search?q=quran" title=" quran"> quran</a> </p> <a href="https://publications.waset.org/abstracts/145501/the-redundant-kana-a-pragmatic-reading" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/145501.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">130</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> A Rare Case of Metastatic Basal Cell Carcinoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nitesh%20Kumar">Nitesh Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=Eoin%20Twohig"> Eoin Twohig</a>, <a href="https://publications.waset.org/abstracts/search?q=jasparl%20cheema"> jasparl cheema</a>, <a href="https://publications.waset.org/abstracts/search?q=Sadiq%20mawji"> Sadiq mawji</a>, <a href="https://publications.waset.org/abstracts/search?q=Yousif%20al%20najjar"> Yousif al najjar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Basal cell carcinoma (BCC) is the commonest cutaneous malignancy affecting humans. Despite this, distant spread is exceptionally rare. Metastatic BCC (mBCC) is estimated to occur in 0.0028 - 0.5%. it aim to illustrate with the aid of histological slides, a case of mBCC occurring in a fit and well 67-year-old. Initial diagnosis of desmoplastic BCC was made in 2006 from a scalp biopsy with the lesion then being excised. Re-excision of local recurrence was undertaken the following year. In 2014 the patient presented with an ipsilateral level 2a mass. Fine Needle Aspiration raised the suspicion of metastatic carcinoma. The patient had excision of two nodes from the left neck alongside pharyngeal tonsillectomy and tongue base biopsies. Histologically, the nodes closely resembled the immunophenotype of the initial scalp lesion. The patient subsequently had a modified radical neck dissection, and residual mBCC was excised from the left Sternocleidomastoid muscle. In 2023 the patient developed haematuria. On further investigation bilateral lung lesions on CT were noted with subsequent biopsy confirming mBCC. Spinal and renal lesions have also been found. Histopathology showed clear resemblance of the lung metastases to both those in the neck and the primary (scalp BCC) – with no squamous differentiation seen. The time span from primary to occurrence of lung metastasis (18 years) affirms the indolent and slow growing nature of BCC.  This case fulfils Lattes and Kessler diagnostic criteria. High risk cases are described as those with advanced local presentation, primary tumour on the Head and Neck and locally recurrent lesions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=BCC" title="BCC">BCC</a>, <a href="https://publications.waset.org/abstracts/search?q=metastasis" title=" metastasis"> metastasis</a>, <a href="https://publications.waset.org/abstracts/search?q=rare" title=" rare"> rare</a>, <a href="https://publications.waset.org/abstracts/search?q=skin%20cancer" title=" skin cancer"> skin cancer</a> </p> <a href="https://publications.waset.org/abstracts/184478/a-rare-case-of-metastatic-basal-cell-carcinoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184478.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">57</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Canthin-6-One Alkaloid Inhibits NF-κB and AP-1 Activity: An Inhibitory Action At Transcriptional Level</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fadia%20Gafri">Fadia Gafri</a>, <a href="https://publications.waset.org/abstracts/search?q=Kathryn%20Mckintosh"> Kathryn Mckintosh</a>, <a href="https://publications.waset.org/abstracts/search?q=Louise%20Young"> Louise Young</a>, <a href="https://publications.waset.org/abstracts/search?q=Alan%20Harvey"> Alan Harvey</a>, <a href="https://publications.waset.org/abstracts/search?q=Simon%20Mackay"> Simon Mackay</a>, <a href="https://publications.waset.org/abstracts/search?q=Andrew%20Paul"> Andrew Paul</a>, <a href="https://publications.waset.org/abstracts/search?q=Robin%20Plevin"> Robin Plevin </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor found originally to play a key role in regulating inflammation. However considerable evidence links this pathway to the suppression of apoptosis, cellular transformation, proliferation and invasion (Aggarwal et al., 2006). Moreover, recent studies have also linked inflammation to cancer progression making NF-κB overall a promising therapeutic target for drug discovery (Dobrovolskaia & Kozlov, 2005). In this study we examined the effect of the natural product canthin-6-one (SU182) as part of a CRUK small molecule drug discovery programme for effects upon the NF-κB pathway. Initial studies demonstrated that SU182 was found to have good potency against the inhibitory kappa B kinases (IKKs) at 30M in vitro. However, at concentrations up to 30M, SU182 had no effect upon TNFα stimulated loss in cellular IκBα or p65 phosphorylation in the keratinocyte cell line NCTC2544. Nevertheless, 30M SU182 reduced TNF-α / PMA-induced NF-κB-linked luciferase reporter activity to (22.9 ± 5%) and (34.6± 3 %, P<0.001) respectively, suggesting an action downstream of IKK signalling. Indeed, SU182 neither decreased NF-κB-DNA binding as assayed by EMSA nor prevented the translocation of p65 (NF-κB) to the nucleus assessed by immunofluorescence and subcellular fractionation. In addition to the inhibition of transcriptional activity of TNFα-induced NF-κB reporter activity SU182 significantly reduced PMA-induced AP-1-linked luciferase reporter activity to about (48± 9% at 30M, P<0.001) . This mode of inhibition was not sufficient to prevent the activation of NF-κB dependent induction of other proteins such as COX-2 and iNOS, or activated MAP kinases (p38, JNK and ERK1/2) in LPS stimulated RAW 264.7 macrophages. Taken together these data indicate the potential for SU182 to interfere with the transcription factors NF-κB and AP-1 at transcriptional level. However, no potential anti-inflammatory effect was indicated, further investigation for other NF-κB dependent proteins linked to survival are also required to identify the exact mechanism of action. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Canthin-6-one" title="Canthin-6-one">Canthin-6-one</a>, <a href="https://publications.waset.org/abstracts/search?q=NF-%CE%BAB" title=" NF-κB"> NF-κB</a>, <a href="https://publications.waset.org/abstracts/search?q=AP-1" title=" AP-1"> AP-1</a>, <a href="https://publications.waset.org/abstracts/search?q=phosphorylation" title=" phosphorylation"> phosphorylation</a>, <a href="https://publications.waset.org/abstracts/search?q=Nuclear%20translocation" title=" Nuclear translocation"> Nuclear translocation</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA-binding%20activity" title=" DNA-binding activity"> DNA-binding activity</a>, <a href="https://publications.waset.org/abstracts/search?q=inflammatory%20proteins." title=" inflammatory proteins."> inflammatory proteins.</a> </p> <a href="https://publications.waset.org/abstracts/20446/canthin-6-one-alkaloid-inhibits-nf-kb-and-ap-1-activity-an-inhibitory-action-at-transcriptional-level" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20446.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">458</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Prednisone and Its Active Metabolite Prednisolone Attenuate Lipid Accumulation in Macrophages</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20Jeries">H. Jeries</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Volkova"> N. Volkova</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20G.%20Iglesias"> C. G. Iglesias</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Najjar"> M. Najjar</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Rosenblat"> M. Rosenblat</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Aviram"> M. Aviram</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Hayek"> T. Hayek</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Synthetic forms of glucocorticoids (e.g., prednisone, prednisolone) are anti-inflammatory drugs which are widely used in clinical practice. The role of glucocorticoids (GCs) in cardiovascular diseases including atherosclerosis is highly controversial, and their impact on macrophage foam cell formation is still unknown. Our aim was to investigate the effects of prednisone or its active metabolite, prednisolone, on macrophage oxidative stress and lipid metabolism using in-vivo, ex-vivo and in-vitro systems. Methods: The in-vivo study included C57BL/6 mice which were intraperitoneally injected with prednisone or prednisolone (5mg/kg) for 4 weeks, followed by lipid metabolism analyses in the mice aorta, and in peritoneal macrophages (MPM). In the ex-vivo study, we analyzed the effect of serum samples obtained from 9 healthy volunteers before or after treatment with oral prednisone (20mg for 5 days), on J774A.1 macrophage atherogenicity. In-vitro studies were conducted using J774A.1 macrophages, human monocyte derived macrophages (HMDM) and fibroblasts. Cells were incubated with increasing concentrations (0-200 ng/ml) of prednisone or prednisolone, followed by determination of cellular oxidative status, triglyceride and cholesterol metabolism. Results: Prednisone or prednisolone treatment resulted in a significant reduction in triglycerides and mainly in cholesterol cellular accumulation in MPM or in J774A.1 macrophages incubated with human serum. Similar resulted were noted in HMDM or in J774A.1 macrophages which were directly incubated with the GCs. These effects were associated with GCs inhibitory effect on triglycerides and cholesterol biosynthesis rates, throughout downregulation of diacylglycerol acyltransferase1 (DGAT1) expression, and of the sterol regulatory element binding protein (SREBP2) and HMGCR expression, respectively. In parallel to prednisone or prednisolone induced reduction in macrophage triglyceride content, paraoxonase 2 (PON2) expression was significantly upregulated. GCs-induced reduction of cellular triglyceride and cholesterol mass was mediated by the GCs receptors on macrophages since the GCs receptor antagonist (RU 486) abolished these effects. In fibroblasts, unlike macrophages, prednisone or prednisolone showed no anti-atherogenic effects. Conclusions: Prednisone or prednisolone are anti-atherogenic since they protected macrophages from lipid accumulation and foam cell formation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=atherosclerosis" title="atherosclerosis">atherosclerosis</a>, <a href="https://publications.waset.org/abstracts/search?q=cholesterol" title=" cholesterol"> cholesterol</a>, <a href="https://publications.waset.org/abstracts/search?q=foam%20cell" title=" foam cell"> foam cell</a>, <a href="https://publications.waset.org/abstracts/search?q=macrophage" title=" macrophage"> macrophage</a>, <a href="https://publications.waset.org/abstracts/search?q=prednisone" title=" prednisone"> prednisone</a>, <a href="https://publications.waset.org/abstracts/search?q=prednisolone" title=" prednisolone"> prednisolone</a>, <a href="https://publications.waset.org/abstracts/search?q=triglycerides" title=" triglycerides"> triglycerides</a> </p> <a href="https://publications.waset.org/abstracts/102695/prednisone-and-its-active-metabolite-prednisolone-attenuate-lipid-accumulation-in-macrophages" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/102695.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">145</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>