The Dodgers’ World Series run brought attention to a rare disease. Annexon is stepping up to the plate.

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site_logos['cstoredive'] = { domain: 'cstoredive', site_name: "C-Store Dive", alt_text: "C-Store Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cstore_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cstore_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cstore_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cstore_black.svg", } }; site_logos['customerexperiencedive'] = { domain: 'customerexperiencedive', site_name: "CX Dive", alt_text: "CX Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cx_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cx_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cx_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cx_black.svg", } }; site_logos['cybersecuritydive'] = { domain: 'cybersecuritydive', site_name: "Cybersecurity Dive", alt_text: "Cybersecurity Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cybersecurity_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cybersecurity_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cybersecurity_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/cybersecurity_black.svg", } }; 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site_logos['healthcaredive'] = { domain: 'healthcaredive', site_name: "Healthcare Dive", alt_text: "Healthcare Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/healthcare_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/healthcare_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/healthcare_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/healthcare_black.svg", } }; site_logos['highereddive'] = { domain: 'highereddive', site_name: "Higher Ed Dive", alt_text: "Higher Ed Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/highered_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/highered_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/highered_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/highered_black.svg", } }; site_logos['hoteldive'] = { domain: 'hoteldive', site_name: "Hotel Dive", alt_text: "Hotel Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/hotel_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/hotel_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/hotel_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/hotel_black.svg", } }; site_logos['hrdive'] = { domain: 'hrdive', site_name: "HR Dive", alt_text: "HR Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/hr_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/hr_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/hr_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/hr_black.svg", } }; site_logos['k12dive'] = { domain: 'k12dive', site_name: "K-12 Dive", alt_text: "K-12 Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/k12_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/k12_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/k12_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/k12_black.svg", } }; site_logos['legaldive'] = { domain: 'legaldive', site_name: "Legal Dive", alt_text: "Legal Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/legal_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/legal_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/legal_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/legal_black.svg", } }; site_logos['manufacturingdive'] = { domain: 'manufacturingdive', site_name: "Manufacturing Dive", alt_text: "Manufacturing Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/manufacturing_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/manufacturing_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/manufacturing_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/manufacturing_black.svg", } }; site_logos['marketingdive'] = { domain: 'marketingdive', site_name: "Marketing Dive", alt_text: "Marketing Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/marketing_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/marketing_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/marketing_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/marketing_black.svg", } }; site_logos['medtechdive'] = { domain: 'medtechdive', site_name: "MedTech Dive", alt_text: "MedTech Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/medtech_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/medtech_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/medtech_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/medtech_black.svg", } }; site_logos['mobilemarketer'] = { domain: 'mobilemarketer', site_name: "Mobile Marketer", alt_text: "Mobile Marketer logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/mobilemarketer_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/mobilemarketer_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/mobilemarketer_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/mobilemarketer_black.svg", } }; site_logos['multifamilydive'] = { domain: 'multifamilydive', site_name: "Multifamily Dive", alt_text: "Multifamily Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/multifamily_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/multifamily_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/multifamily_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/multifamily_black.svg", } }; site_logos['packagingdive'] = { domain: 'packagingdive', site_name: "Packaging Dive", alt_text: "Packaging Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/packaging_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/packaging_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/packaging_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/packaging_black.svg", } }; site_logos['paymentsdive'] = { domain: 'paymentsdive', site_name: "Payments Dive", alt_text: "Payments Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/payments_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/payments_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/payments_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/payments_black.svg", } }; site_logos['pharmavoice'] = { domain: 'pharmavoice', site_name: "PharmaVoice", alt_text: "PharmaVoice logo", is_current_site: true, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/pharmavoice_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/pharmavoice_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/pharmavoice_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/pharmavoice_black.svg", } }; site_logos['proformative'] = { domain: 'proformative', site_name: "Proformative", alt_text: "Proformative logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/proformative_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/proformative_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/proformative_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/proformative_black.svg", } }; site_logos['restaurantdive'] = { domain: 'restaurantdive', site_name: "Restaurant Dive", alt_text: "Restaurant Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/restaurant_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/restaurant_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/restaurant_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/restaurant_black.svg", } }; site_logos['retaildive'] = { domain: 'retaildive', site_name: "Retail Dive", alt_text: "Retail Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/retail_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/retail_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/retail_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/retail_black.svg", } }; site_logos['smartcitiesdive'] = { domain: 'smartcitiesdive', site_name: "Smart Cities Dive", alt_text: "Smart Cities Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/smartcities_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/smartcities_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/smartcities_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/smartcities_black.svg", } }; site_logos['socialmediatoday'] = { domain: 'socialmediatoday', site_name: "Social Media Today", alt_text: "Social Media Today logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/smt_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/smt_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/smt_color.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/smt_color.svg", } }; site_logos['supplychaindive'] = { domain: 'supplychaindive', site_name: "Supply Chain Dive", alt_text: "Supply Chain Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/supplychain_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/supplychain_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/supplychain_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/supplychain_black.svg", } }; site_logos['truckingdive'] = { domain: 'truckingdive', site_name: "Trucking Dive", alt_text: "Trucking Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/trucking_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/trucking_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/trucking_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/trucking_black.svg", } }; site_logos['utilitydive'] = { domain: 'utilitydive', site_name: "Utility Dive", alt_text: "Utility Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/utility_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/utility_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/utility_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/utility_black.svg", } }; site_logos['wastedive'] = { domain: 'wastedive', site_name: "Waste Dive", alt_text: "Waste Dive logo", is_current_site: false, white: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/waste_white.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/waste_white.svg", }, black: { png: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/waste_black.png", svg: "https://d12v9rtnomnebu.cloudfront.net/logo/publications/waste_black.svg", } }; // Get the dive domain and return the dive logo object, or null if it doesn't exist in site_logos function getDivesiteLogoObject(link_url, alt_domain='') { let dive_domain; // Split link URL on 'adurl=' and take what comes after as the ad url const ad_url = decodeURIComponent(link_url.split('adurl=')[1]); // Split on . to get an array of hostname segments const dive_domain_array = new URL(ad_url).hostname.split('.'); // Retrieve the second to last element of the hostname array, which should always be the domain dive_domain = dive_domain_array[dive_domain_array.length - 2] if (alt_domain) { // If alt_domain has been specified, normalize it. i.e. "HR Dive", "http://hrdive.com", etc. => "hrdive" // This will override the link url's domain. dive_domain = alt_domain.replace(/\s+/g, '').replace(/^(https?:\/\/)?(www\.)?|\.com.*|\?.*|#.*/gi, '').toLowerCase(); } // Return the site logos object for this domain if it exists, or null if it does not if (site_logos[dive_domain]) { return site_logos[dive_domain]; } else { // Fallback logo const url_prefix = "https://d12v9rtnomnebu.cloudfront.net/divesite/responsive_ad_assets/small_logos/"; return { domain: 'industrydive', site_name: 'Industry Dive', alt_text: 'Industry Dive logo', white: { svg: url_prefix + 'industrydive-small-white.svg', png: url_prefix + 'industrydive-small-white.png', }, black: { svg: url_prefix + 'industrydive-small-black.svg', png: url_prefix + 'industrydive-small-black.png', } } } } eventer(messageEvent, function (e) { var key = e.message ? "message" : "data"; var data = e[key]; var eventName = data.message || 'ignore'; if (eventName == 'adContentAvailable') { var $ad_element; $ad_element = $('div').filter('[data-container-ad-unit-id="' + data.adUnit + '-' + window.dfp_visibility + '"]'); $ad_element.hide() var nativeAdEditorialSelector = '.sidebar .hybrid-ad-wrapper .native-ad-editorial'; var nativeAdEditorialExists = $(nativeAdEditorialSelector).length > 0; if ( nativeAdEditorialExists ) { $(nativeAdEditorialSelector).closest('.hybrid-ad-wrapper').addClass('native-ad-editorial-sidebar-border'); } // Inline homepage ad $('.feed-item-ad .hybrid-ad-wrapper a').each(function (index, element) { window.updateGamAdUrl(element, 'inline'); }); // Editorial native ad sidebar // NOTE: must go before inline native ad to ensure correct location added $('.sidebar .native-ad.editorial a').each(function (index, element) { window.updateGamAdUrl(element, 'sidebar'); }); // Editorial native ad inline $('.native-ad.editorial a').each(function (index, element) { window.updateGamAdUrl(element, 'inline'); }); // Sidebar ad $('.sidebar .hybrid-ad-wrapper a').each(function (index, element) { window.updateGamAdUrl(element, 'sidebar'); }); } }, false); var googletag = googletag || {}; googletag.cmd = googletag.cmd || []; googletag.cmd.push(function () { var desktopWidth = 1024; if (window.innerWidth >= desktopWidth) { window.dfp_visibility = 'desktop'; } else { window.dfp_visibility = 'mobile'; } var dfpDisplayConfiguration = { "prestitialEnabled": true, "leaderboardEnabled": true, "sidebarAdsEnabled": true, "visibility": window.dfp_visibility }; if (window.dfp_visibility == 'desktop') { if (typeof prestitialAds == 'object' && prestitialAds.pageIsPrestitialEligible()) { googletag.defineSlot('/21662595662/pharmavoice/pharmavoiceprestitial', [[500, 300], [640, 480]], 'paychekgoeshere').addService(googletag.pubads()); } if (dfpDisplayConfiguration.leaderboardEnabled) { googletag.defineSlot('/21662595662/pharmavoice/pharmavoiceleaderboard', [[970, 180], [728, 90], [970, 90]], 'dfp-leaderboard-desktop').addService(googletag.pubads()); googletag.pubads().addEventListener('slotRenderEnded', function (event) { if ((event.slot.getAdUnitPath() === '/21662595662/pharmavoice/pharmavoiceleaderboard' || event.slot.getAdUnitPath() === '/21662595662/pharmavoice/pharmavoiceleaderboard') && !event.isEmpty ) { $(window).blur(function () { if (document.activeElement === $('#dfp-leaderboard-desktop iframe')[0] || document.activeElement === $('#dfp-leaderboard-desktop iframe')[0]) { try { localStorage.setItem('leaderboard_signup_path', document.location.pathname); } catch (e) { // local storage could not be available due to privacy settings or something } } }); } }); } if (dfpDisplayConfiguration.sidebarAdsEnabled) { googletag.defineSlot('/21662595662/pharmavoice/pharmavoicehybrid1', [[300, 250], 'fluid', [160, 600]], 'dfp-hybrid1-desktop').addService(googletag.pubads()); } googletag.defineSlot('/21662595662/pharmavoice/pharmavoicehybrid2', [[300, 250], 'fluid'], 'dfp-hybrid2-desktop').addService(googletag.pubads()); googletag.defineSlot('/21662595662/pharmavoice/pharmavoicehybrid3', [[300, 250], 'fluid'], 'dfp-hybrid3-desktop').addService(googletag.pubads()); googletag.defineSlot('/21662595662/pharmavoice/pharmavoicehybrid4', [[300, 250], 'fluid'], 'dfp-hybrid4-desktop').addService(googletag.pubads()); googletag.defineSlot('/21662595662/pharmavoice/pharmavoicethankyouhybrid1', ['fluid'], 'dfp-thankyouhybrid1-desktop').addService(googletag.pubads()); googletag.defineSlot('/21662595662/pharmavoice/pharmavoicethankyouhybrid2', ['fluid'], 'dfp-thankyouhybrid2-desktop').addService(googletag.pubads()); } else { googletag.defineSlot('/21662595662/pharmavoice/pharmavoicehybrid1', [[300, 250], 'fluid'], 'dfp-hybrid1-mobile').addService(googletag.pubads()); googletag.defineSlot('/21662595662/pharmavoice/pharmavoicehybrid2', [[300, 250], 'fluid'], 'dfp-hybrid2-mobile').addService(googletag.pubads()); googletag.defineSlot('/21662595662/pharmavoice/pharmavoicehybrid3', [[300, 250], 'fluid'], 'dfp-hybrid3-mobile').addService(googletag.pubads()); googletag.defineSlot('/21662595662/pharmavoice/pharmavoicehybrid4', [[300, 250], 'fluid'], 'dfp-hybrid4-mobile').addService(googletag.pubads()); 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Annexon is stepping up to the plate. </h1> <p>The company is looking to score an FDA nod for its investigational therapy that targets a molecule linked to Guillain-Barré syndrome and other autoimmune diseases.</p> </div> <div class="byline"> <div class="article-byline"> <div class="date date-bottom-border"> <span class="published-info"> Published Nov. 19, 2024 </span> </div> <div class="byline-row "> <div class="author "> <span>By</span> Alexandra Pecci </div> <div class="social-share"> <ul class="social-icon-list"> <li> <a href="http://www.linkedin.com/shareArticle?mini=true&url=https%3A//www.pharmavoice.com/news/annexon-guillain-barre-rare-disease-freddie-freeman/733266/&title=The%20Dodgers%E2%80%99%20World%20Series%20run%20brought%20attention%20to%20a%20rare%20disease.%20Annexon%20is%20stepping%20up%20to%20the%20plate." aria-label="Share article to Linkedin" class="social-icon analytics t-article-byline-social-linkedin"> <img src="/static/img/social_icons/article_page/linkedin.svg?092716141024" alt="Post to LinkedIn"> <span class="social-icon__text">post</span> </a> </li> <li> <a href="https://www.facebook.com/sharer/sharer.php?u=https%3A//www.pharmavoice.com/news/annexon-guillain-barre-rare-disease-freddie-freeman/733266/" aria-label="Share article to Facebook" class="social-icon analytics t-article-byline-social-facebook"> <img src="/static/img/social_icons/article_page/facebook.svg?440116200824" alt="Share on Facebook"> <span class="social-icon__text">share</span> </a> </li> <li> <a href="https://twitter.com/intent/tweet?text=The%20Dodgers%E2%80%99%20World%20Series%20run%20brought%20attention%20to%20a%20rare%20disease.%20Annexon%20is%20stepping%20up%20to%20the%20plate.%20https%3A//www.pharmavoice.com/news/annexon-guillain-barre-rare-disease-freddie-freeman/733266/%20via%20@PharmaVoice" aria-label="Share article to X/Twitter" class="social-icon analytics t-article-byline-social-twitter"> <img src="/static/img/social_icons/article_page/x.svg?092716141024" alt="Post on X"> <span class="social-icon__text">post</span> </a> </li> <li> <a href="javascript:window.print()" aria-label="Print article" class="social-icon js-social-icon-print"> <img src="/static/img/social_icons/article_page/print.svg?440116200824" alt="Print this page"> <span class="social-icon__text">print</span> </a> </li> <li> <a href="/cdn-cgi/l/email-protection#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" aria-label="Share article with email" class="social-icon analytics t-article-byline-social-email"> <img src="/static/img/social_icons/article_page/email.svg?092716141024" alt="Email this page"> <span class="social-icon__text">email</span> </a> </li> <li> <a href="/selfservice/article-licensing/submit/?newspostUrl=https://www.pharmavoice.com/news/annexon-guillain-barre-rare-disease-freddie-freeman/733266/" aria-label="License article" class="social-icon js-social-icon-license analytics t-article-byline-social-licensing"> <img src="/static/img/social_icons/article_page/cart.svg?092716141024" alt="License this article"> <span class="social-icon__text">license</span> </a> </li> </ul> </div> </div> </div> </div> <figure class="inside_story"> <div class="figure_content article-hero-img"> <img class="" src="https://imgproxy.divecdn.com/nMvCX9wq9DNntZrdGkdWrO4dpSK6dJlBX8YJ78eVZh0/g:ce/rs:fill:1200:675:1/Z3M6Ly9kaXZlc2l0ZS1zdG9yYWdlL2RpdmVpbWFnZS9SVFMxOVFTNUFfMV92NG5Eb3NZLkpQRw==.webp" width="1200" height="675" srcset="https://imgproxy.divecdn.com/2Q8pRxv30eY8unAheVSiMcRnT9g9OPrNLg2FkBfEOzs/g:ce/rs:fill:400:225:1/Z3M6Ly9kaXZlc2l0ZS1zdG9yYWdlL2RpdmVpbWFnZS9SVFMxOVFTNUFfMV92NG5Eb3NZLkpQRw==.webp 400w, https://imgproxy.divecdn.com/7T0deVRB9aYmbKhj8OSbnqsQ2AGQW34qVjAptx2nwTQ/g:ce/rs:fill:800:450:1/Z3M6Ly9kaXZlc2l0ZS1zdG9yYWdlL2RpdmVpbWFnZS9SVFMxOVFTNUFfMV92NG5Eb3NZLkpQRw==.webp 800w, https://imgproxy.divecdn.com/nMvCX9wq9DNntZrdGkdWrO4dpSK6dJlBX8YJ78eVZh0/g:ce/rs:fill:1200:675:1/Z3M6Ly9kaXZlc2l0ZS1zdG9yYWdlL2RpdmVpbWFnZS9SVFMxOVFTNUFfMV92NG5Eb3NZLkpQRw==.webp 1200w, https://imgproxy.divecdn.com/OgPevvkZ0uJvVcrJg0n8hyJufzJLLL6AwXIDxapaqlI/g:ce/rs:fill:1600:900:1/Z3M6Ly9kaXZlc2l0ZS1zdG9yYWdlL2RpdmVpbWFnZS9SVFMxOVFTNUFfMV92NG5Eb3NZLkpQRw==.webp 1600w" sizes="(min-width: 64em) 60vw, 100vw" alt="Freddie Freeman" > </div> <figcaption class="inside_story_caption"> <span class="caption_text"> Oct 28, 2024; Los Angeles Dodgers first baseman Freddie Freeman hits a two-run home run against the New York Yankees in game three of the 2024 MLB World Series. Earlier in the season, Freeman stepped away from baseball when his son was diagnosed with Guillain-Barré syndrome. </span> <span class="source_text"> <p>Brad Penner/Imagn Images/Reuters</p> </span> </figcaption> </figure> </div> <div class="row"> <div class="article-large-12 columns article-wrapper"> <div class="print-wrapper"> <div class=" large medium article-body"> <div class="text-to-speech"> <button class="text-to-speech__button button"> <img class="text-to-speech__button__icon" src="/static/images/audio_icon.svg?482016190122" alt=""/> Listen to the article <span class="text-to-speech__button__audio-length">5 min</span> </button> <div class="text-to-speech__controls"> <audio controls class="js-text-to-speech" preload="none"> <source src="http://res.cloudinary.com/dmgi9movl/video/upload/q_1/v1731967976/news/text_to_speech/annexon-guillain-barre-rare-disease-freddie-freeman_aitpkm.wav" type="audio/mp3"> </audio> <div class="text-to-speech__controls__text"> This audio is auto-generated. Please let us know if you have <a href="/contact/">feedback</a>. </div> </div> </div> <p>Rare diseases aren’t typically a part of baseball’s news cycle. But late last summer, Los Angeles Dodgers first baseman Freddie Freeman had to step away from the game for several weeks when his son <a href="https://www.espn.com/mlb/story/_/id/40739913/freddie-freeman-returns-dodgers-son-maximus-recovers-rare-medical-issue">became ill</a> with Guillain-Barré syndrome, a rare, potentially life-threatening neurological disorder. The swell of support for Freeman, who went on to become the 2024 World Series MVP, suddenly raised the profile of the disease. </p> <p>In GBS, the immune system mistakenly attacks part of the peripheral nervous system. Symptoms come on suddenly and progress rapidly, starting with tingling and weakness and sometimes leading to paralysis.</p> <div class="hybrid-ad-wrapper show-small hide-large"> <div class="hybrid-ad-inner-wrapper"> <div class="show-small hide-large"> <div data-container-ad-unit-id="/21662595662/pharmavoice/pharmavoicehybrid1-mobile"></div> <div id="dfp-hybrid1-mobile"> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script> waitToLoadAds.push(function() { googletag.cmd.push(function() { if (window.dfp_visibility == 'mobile' ) { googletag.display('dfp-hybrid1-mobile'); googletag.pubads().addEventListener('slotRenderEnded', function (event) { var adUnitPath = '/21662595662/pharmavoice/pharmavoicehybrid1'; var onProformative = false; if (onProformative && event.slot.getAdUnitPath() === adUnitPath && !event.isEmpty ) { var adUnitPathWithVisibility = adUnitPath + '-mobile'; var selector = '.pf-comments__ad-wrapper [data-container-ad-unit-id="' + adUnitPathWithVisibility + '"]'; if (!$(selector).closest('.pf-comments__ad-wrapper').hasClass('borders')) { $(selector).closest('.pf-comments__ad-wrapper').addClass('borders') } } }); } }); }); </script> </div> </div> </div> </div> <div class="hybrid-ad-wrapper hide-small show-large"> <div class="hybrid-ad-inner-wrapper"> <div class="hide-small show-large"> <div data-container-ad-unit-id="/21662595662/pharmavoice/pharmavoicehybrid2-desktop"></div> <div id="dfp-hybrid2-desktop"> <script> waitToLoadAds.push(function() { googletag.cmd.push(function() { if (window.dfp_visibility == 'desktop' ) { googletag.display('dfp-hybrid2-desktop'); googletag.pubads().addEventListener('slotRenderEnded', function (event) { var adUnitPath = '/21662595662/pharmavoice/pharmavoicehybrid2'; var onProformative = false; if (onProformative && event.slot.getAdUnitPath() === adUnitPath && !event.isEmpty ) { var adUnitPathWithVisibility = adUnitPath + '-desktop'; var selector = '.pf-comments__ad-wrapper [data-container-ad-unit-id="' + adUnitPathWithVisibility + '"]'; if (!$(selector).closest('.pf-comments__ad-wrapper').hasClass('borders')) { $(selector).closest('.pf-comments__ad-wrapper').addClass('borders') } } }); } }); }); </script> </div> </div> </div> </div> <p>“It starts in your feet and moves up through your body,” said Douglas Love, president and CEO of Annexon Biosciences, which has a late-stage GBS candidate in the pipeline. “One in four patients are going to be on a ventilator within a couple of weeks.”</p> <figure class="image-right inside_story"> <div class="figure_content"> <div><img alt="Douglas Love headshot" data-imagemodel="170488" src="https://imgproxy.divecdn.com/LfmfGBPUYTbLlIz829DjhDsv9c0TtT4aAOxYM2bRiUk/g:ce/rs:fit:1600:0/Z3M6Ly9kaXZlc2l0ZS1zdG9yYWdlL2RpdmVpbWFnZS9Eb3VnLnBuZw==.webp"/></div> </div> <figcaption class="inside_story_caption"> <div class="caption_text">Douglas Love, CEO, Annexon Biosciences</div> <div class="source_text">Permission granted by Annexon</div> <div class="clearfix"> </div> </figcaption> </figure> <p>That common trajectory was the same for Freeman’s three-year-old son, Maximus. Within a matter of days, he developed a limp, couldn’t sit up and eventually couldn’t breathe on his own.</p> <p>Although the “why” behind GBS is unknown, it strikes days or weeks after another illness, such as a respiratory or gastrointestinal bacterial or viral infection, has cleared.</p> <p>“There’s no disease that I'm familiar with that’s like Guillain-Barré syndrome. It happens in patients who are otherwise completely healthy,” said Love. GBS impacts 3,000-6,000 people in the U.S. each year, according to <a href="https://www.cdc.gov/campylobacter/signs-symptoms/guillain-barre-syndrome.html#:~:text=Number%20of%20people%20affected,of%20Campylobacter%20infections%20develops%20GBS.">the CDC</a>, and is often treated with off-label intravenous immunoglobulin therapy.</p> <p>“It has some effect, depending upon how severe the disease is. But the more severe the disease, the less effective IVIG is,” Love said. </p> <p>However, there’s no FDA-approved treatment for the disease, and while most patients recover, the process can be long and brutal. </p> <div class="pullquote"> <hr/> <div class="pq-hr-wrapper"> <p class="pq-quote">“It's a neurological nightmare for patients that deserves an appropriate therapy."</p> <div class="pq-headshot"><img alt="" class="pq-headshot-img-hidden" src="https://d12v9rtnomnebu.cloudfront.net/diveimages/corporate_site/teampage/square_profiles/placeholder-200.png"/></div> <div class="pq-speaker-details"> <p class="pq-speaker">Douglas Love</p> <p class="pq-speaker-title">CEO, Annexon Biosciences</p> </div> </div> <hr/></div> <p>Annexon Biosciences wants to change that. The company successfully completed a pivotal phase 3 trial for its lead candidate, ANX005, an immunotherapy that targets and blocks C1q, the molecule that initiates the classical complement pathway associated with GBS. ANX005 <a href="https://ir.annexonbio.com/news-releases/news-release-details/annexon-biosciences-announces-fda-fast-track-designation-novel">received</a> FDA fast track and orphan drug designations.</p> <p>“We're pursuing what is a unique or diverse approach from other complement programs in that we're targeting upstream complement activity,” Love said. “It localizes and activates complement or inflammation right on disease tissue, so you can be more proximal in your approach in targeting aberrant inflammation.”</p> <p>A June <a href="https://ir.annexonbio.com/news-releases/news-release-details/annexon-presented-additional-positive-phase-3-results-anx005-c1q">phase 3</a> readout showed ANX005 had statistically significant results on key endpoints, including on the GBS disability scale.</p> <p>Unlike IVIG, which is administered over five days, ANX005 is given by IV infusion within a few hours and works that quickly, too, Love said.</p> <div class="hybrid-ad-wrapper show-small hide-large"> <div class="hybrid-ad-inner-wrapper"> <div class="show-small hide-large"> <div data-container-ad-unit-id="/21662595662/pharmavoice/pharmavoicehybrid2-mobile"></div> <div id="dfp-hybrid2-mobile"> <script> waitToLoadAds.push(function() { googletag.cmd.push(function() { if (window.dfp_visibility == 'mobile' ) { googletag.display('dfp-hybrid2-mobile'); googletag.pubads().addEventListener('slotRenderEnded', function (event) { var adUnitPath = '/21662595662/pharmavoice/pharmavoicehybrid2'; var onProformative = false; if (onProformative && event.slot.getAdUnitPath() === adUnitPath && !event.isEmpty ) { var adUnitPathWithVisibility = adUnitPath + '-mobile'; var selector = '.pf-comments__ad-wrapper [data-container-ad-unit-id="' + adUnitPathWithVisibility + '"]'; if (!$(selector).closest('.pf-comments__ad-wrapper').hasClass('borders')) { $(selector).closest('.pf-comments__ad-wrapper').addClass('borders') } } }); } }); }); </script> </div> </div> </div> </div> <div class="hide-small show-large" id="desktop-inline-signup"></div> <p>“Our drug is quite simple. It is designed to block C1q immediately upon administration,” he said. “It speaks to the power of our approach, which is quickly shutting down C1q, shutting down the disease process, and allowing patients to move from a state of decline to stopping the disease process.”</p> <p>Love said the company plans to file its biologics license application for ANX005 in the first half of 2025. </p> <p>Although the GBS market is small, Annexon will have it cornered as the first and only approved treatment if it wins an FDA OK. In addition, Love said there’s a 90% compliance rate in treating GBS, and 80% of the disease’s incidence occurs in five large states and in “just a few hundred hospitals.” </p> <p>“Although [GBS] happens acutely and sporadically, it happens where you have more people,” he said. “That allows us to have a very efficient commercial footprint.” </p> <p>ANX005 isn’t the only product in Annexon’s pipeline targeting C1q. Its other flagship programs are in geographic atrophy and complement-mediated autoimmune diseases, as well as programs in Huntington’s disease, ALS and lupus nephritis.</p> <p>“We're the first, and thus far, the only company targeting C1q in the clinic,” Love said. “By targeting C1q where it initiates this inflammatory disease process, it allows us to pursue a wide swath of indications that you don't necessarily always see with complement programs.” </p> <p>First up, though, is a chance to change the trajectory of GBS.</p> <p>“It's a neurological nightmare for patients that deserves an appropriate therapy,” Love said. </p> </div> <div class="reading-list recommended-reading"> <h3 class="sidebar-box__header reading-list__header">Recommended Reading</h3> <ul class="list-no-bullets"> <li class="reading-list__item"> <a href="https://www.pharmavoice.com/news/pharma-bro-martin-shkreli-turing-ceo-ron-tilles/732850/" target="_blank" class="reading-list__link analytics 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The Dodgers’ World Series run brought attention to a rare disease. Annexon is stepping up to the plate. | PharmaVoice