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width:17px; height:17px; overflow:hidden; text-decoration:none;"><div style="position:absolute; font-size:17px; overflow:hidden; line-height:17px; letter-spacing:17px;"><a rel="nofollow" class="external text" href="https://en.citizendium.org/wiki/index.php?title=BRCA2_gene&printable=yes"><span title="https://en.citizendium.org/wiki/index.php?title=BRCA2_gene&printable=yes" style="text-decoration:none;">   </span></a></div><a href="/wiki/File:Print_button.png" class="image" title="https://en.citizendium.org/wiki/index.php?title=BRCA2_gene&printable=yes"><img alt="https://en.citizendium.org/wiki/index.php?title=BRCA2_gene&printable=yes" src="/wiki/images/thumb/0/07/Print_button.png/17px-Print_button.png" decoding="async" width="17" height="17" srcset="/wiki/images/thumb/0/07/Print_button.png/26px-Print_button.png 1.5x, /wiki/images/thumb/0/07/Print_button.png/34px-Print_button.png 2x" data-file-width="45" data-file-height="45" /></a></div> </td></tr></tbody></table><font size="2"><i>This editable Main Article is <b>under development</b> and subject to a <a href="/wiki/CZ:Disclaimer" title="CZ:Disclaimer"><b>disclaimer</b></a><b>. </b></i><b></b></font><div style="float:right; margin: .1em .5em;"><b>[<span class="plainlinks plainlinksneverexpand"><a rel="nofollow" class="external text" href="https://citizendium.org/wiki/index.php?title=BRCA2_gene&action=edit&section=0"><font size="2">edit intro</font></a></span>]</b></div> </td></tr></tbody></table></div> <p>In <a href="/wiki/Physiology" title="Physiology">physiology</a>, <b>BRCA2 gene</b> (<b>BRCA-2 gene</b>) is "a <a href="/wiki/index.php?title=Tumor_suppressor_gene&action=edit&redlink=1" class="new" title="Tumor suppressor gene (page does not exist)">tumor suppressor gene</a> located on human chromosome 13 at locus 13q12.3. Mutations of this gene are associated with the formation of familial <a href="/wiki/Breast_cancer" title="Breast cancer">breast</a> and <a href="/wiki/Ovarian_cancer" title="Ovarian cancer">ovarian</a> cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements."<sup id="cite_ref-1" class="reference"><a href="#cite_note-1">[1]</a></sup> </p><p>Women who have <a href="/wiki/BRCA1_gene" title="BRCA1 gene">BRCA1</a> or BRCA2 genes, especially if there is a familial history of <a href="/wiki/Breast_cancer" title="Breast cancer">breast cancer</a>, may be candidates for prophylactic <a href="/wiki/index.php?title=Mastectomy&action=edit&redlink=1" class="new" title="Mastectomy (page does not exist)">mastectomy</a>. <sup id="cite_ref-2" class="reference"><a href="#cite_note-2">[2]</a></sup> </p> <h2><span class="mw-headline" id="References">References</span></h2> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><a href="/wiki/Anonymous" class="mw-redirect" title="Anonymous">Anonymous</a> (2024), <a rel="nofollow" class="external text" href="http://www.nlm.nih.gov/cgi/mesh/2024/MB_cgi?term=BRCA2+gene">BRCA2 gene</a> (English). <i><a href="/wiki/Medical_Subject_Headings" class="mw-redirect" title="Medical Subject Headings">Medical Subject Headings</a></i>. U.S. <a href="/wiki/National_Library_of_Medicine" title="National Library of Medicine">National Library of Medicine</a>.</span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><cite style="font-style:normal" class="external text" id="CITEREFHartmann_LC_''et_al.''">Hartmann LC <i>et al.</i>, "<a rel="nofollow" class="external text" href="http://jnci.oxfordjournals.org/cgi/content/full/93/21/1633">Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers</a>", <i>J Natl Cancer Inst</i> <b>93</b> (21): 1633-1637</cite></span> </li> </ol></div>  </div> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://citizendium.org/wiki/index.php?title=BRCA2_gene&oldid=963469">https://citizendium.org/wiki/index.php?title=BRCA2_gene&oldid=963469</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Special:Categories" title="Special:Categories">Categories</a>: <ul><li><a href="/wiki/Category:CZ_Live" title="Category:CZ Live">CZ Live</a></li><li><a href="/wiki/Category:Health_Sciences_Workgroup" title="Category:Health Sciences Workgroup">Health Sciences Workgroup</a></li><li><a href="/wiki/Category:Oncology_Subgroup" title="Category:Oncology Subgroup">Oncology Subgroup</a></li><li><a href="/wiki/Category:Articles_written_in_American_English" title="Category:Articles written in American English">Articles written in American English</a></li><li><a href="/wiki/Category:All_Content" title="Category:All Content">All Content</a></li><li><a href="/wiki/Category:Health_Sciences_Content" title="Category:Health Sciences Content">Health Sciences Content</a></li><li><a href="/wiki/index.php?title=Category:Oncology_tag&action=edit&redlink=1" class="new" title="Category:Oncology tag (page does not exist)">Oncology tag</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:Health_Sciences_tag" title="Category:Health Sciences tag">Health Sciences tag</a></li><li><a href="/wiki/Category:Suggestion_Bot_Tag" title="Category:Suggestion Bot Tag">Suggestion Bot Tag</a></li></ul></div></div> </div> </div> <div id="mw-navigation"> <h2>Navigation menu</h2> <div id="mw-head"> <nav id="p-personal" class="vector-menu mw-portlet mw-portlet-personal vector-user-menu-legacy" aria-labelledby="p-personal-label" role="navigation" > <h3 id="p-personal-label" class="vector-menu-heading " > <span class="vector-menu-heading-label">Personal tools</span> </h3> <div class="vector-menu-content"> <ul class="vector-menu-content-list"><li id="pt-login" class="mw-list-item"><a href="/wiki/index.php?title=Special:UserLogin&returnto=BRCA2+gene" title="To edit pages, [[Special:RequestAccount|get a contributor account]]. 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