SCSS/CTFG-IMCB Webinar Series 1 Nov 22

<!DOCTYPE html> <html lang="en"> <head> <title>SCSS/CTFG-IMCB Webinar Series 1 Nov 22</title><meta property="og:site_name" content="Stem Cell Society Singapore" /> <meta property="og:title" content="SCSS/CTFG-IMCB Webinar Series 1 Nov 22" /> <meta property="og:description" content="Date:聽聽 19 January 2023 (Thursday) Time:聽聽 4 - 5pm Format: Zoom Webinar (registration is required) Hosted by: Jonathan Loh, IMCB, Singapore" /> <meta property="og:image" content="https://www.stemcell.org.sg/uploads/1/0/3/5/103535018/published/yaqub2x2-re.jpg?1673400289" /> <meta property="og:image" content="https://www.stemcell.org.sg/uploads/1/0/3/5/103535018/published/scss-logo.gif?1559026821" /> <meta property="og:url" content="https://www.stemcell.org.sg/hanna.html" /> <meta http-equiv="Content-Type" content="text/html; charset=utf-8"/> <meta name="viewport" content="width=device-width, initial-scale=1.0"/> <link 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target="_blank"> <span class="wsite-button-inner">Watch Jacobs's webinar on-demand here!</span> </a> <div style="height: 10px; overflow: hidden;"></div></div> <div><div style="height: 20px; overflow: hidden; width: 100%;"></div> <hr class="styled-hr" style="width:100%;"></hr> <div style="height: 20px; overflow: hidden; width: 100%;"></div></div> <div class="wsite-spacer" style="height:50px;"></div> <div><div class="wsite-multicol"><div class="wsite-multicol-table-wrap" style="margin:0 -15px;"> <table class="wsite-multicol-table"> <tbody class="wsite-multicol-tbody"> <tr class="wsite-multicol-tr"> <td class="wsite-multicol-col" style="width:85.625830668324%; padding:0 15px;"> <div class="paragraph"><font size="5"><strong>Date:   19 January 2023</strong> (Thursday)<br /><br /><font><strong>Time:   4</strong></font> <strong>- 5pm</strong><br /><br /><strong>Format:</strong> <strong>Zoom Webinar (registration is required)<br /><br />Hosted by: Jonathan Loh, <em>IMCB, Singapore</em></strong> </font><br /></div> </td> <td class="wsite-multicol-col" style="width:14.374169331676%; padding:0 15px;"> <div class="wsite-spacer" style="height:50px;"></div> </td> </tr> </tbody> </table> </div></div></div> <div><div style="height: 20px; overflow: hidden; width: 100%;"></div> <hr class="styled-hr" style="width:100%;"></hr> <div style="height: 20px; overflow: hidden; width: 100%;"></div></div> <div><div class="wsite-multicol"><div class="wsite-multicol-table-wrap" style="margin:0 -15px;"> <table class="wsite-multicol-table"> <tbody class="wsite-multicol-tbody"> <tr class="wsite-multicol-tr"> <td class="wsite-multicol-col" style="width:64.545454545455%; padding:0 15px;"> <div class="paragraph"><font size="6"><strong><u>Speaker's information</u></strong></font><br /><br /><font size="6"><strong>Jacob (Yacub) HANNA</strong></font><br /><em><span><span>Weizmann Institute of Science</span></span></em><em><font size="4">, Israel</font></em><br /><br /><em><strong><font size="5">"</font></strong></em><font size="5"><strong><em>Ex Utero Embryogenesis: from Naive Pluripotent Stem cells to advanced Embryoid Models</em></strong></font><em><strong><font size="5">"</font></strong></em><br /><br /></div> </td> <td class="wsite-multicol-col" style="width:35.454545454545%; padding:0 15px;"> <div class="wsite-spacer" style="height:48px;"></div> <div><div class="wsite-image wsite-image-border-none " style="padding-top:10px;padding-bottom:10px;margin-left:0px;margin-right:0px;text-align:center"> <a> <img src="/uploads/1/0/3/5/103535018/published/yaqub2x2-re.jpg?1673400289" alt="Picture" style="width:auto;max-width:100%" /> </a> <div style="display:block;font-size:90%"></div> </div></div> </td> </tr> </tbody> </table> </div></div></div> <div class="wsite-spacer" style="height:50px;"></div> <div class="paragraph" style="text-align:justify;"><font size="5"><strong>ABSTRACT</strong></font><br />The identity of somatic and pluripotent cells can be epigenetically reprogrammed and forced to adapt a new functional cell state by different methods and distinct combinations of exogenous factors. The aspiration to utilize such <em>in vitro</em> reprogrammed pluripotent and somatic cells for therapeutic purposes necessitates understanding of the mechanisms of reprogramming and differentiation and elucidating the extent of equivalence of the <em>in vitro</em> derived cells to their <em>in vivo</em> counterparts. In my presentation, I will present my group’s recent advances toward understanding these fundamental questions and further detail our ongoing efforts to generate developmentally unrestricted human naive pluripotent cells with embryonic and extra-embryonic developmental potential. I will expand on new avenues for utilizing custom made electronically controlled <em>ex utero</em> platforms and optimized conditions for growing natural mammalian embryos <em>ex utero</em> for extended periods capturing both the gastrulation and organogenesis until advanced stages, for better studying of stem cell transitions during embryogenesis and organogenesis. I will detail how the latter platforms offered an exclusive technical platform to demonstrate and unleash the self-organizing capacity of mouse naïve PSCs to generate post-gastrulation organ-filled whole synthetic embryos with both embryonic and extraembryonic compartment <em>ex utero</em>. Collectively, I will be highlighting prospects for new platforms for advancing human disease and developmental modelling.<br /><br /><font size="5"><strong>BIO</strong></font><br />Born in Rama, an Arab Palestinian village in the Galilee region of Israel, Prof. <strong>Jacob (Yaqub) Hanna</strong> earned his BSc in medical science (2001), PhD in immunology (2007)<span>,</span> and MD in clinical medicine <em>summa cum laude</em> (2007) from the Hebrew University of Jerusalem. He conducted postdoctoral research at the Whitehead Institute for Biomedical Research at MIT. He joined the department of Molecular Genetics at the Weizmann Institute in 2011.<br /><br />Prof. Hanna is pioneering techniques in induced naïve pluripotency from adult cell and synthetic whole embryo models made solely from stem cells ex utero. Induced pluripotent stem (iPS) cells have regenerative properties almost identical to those of embryonic stem cells, but can be created from adult cells without using an egg or fetal material. Prof. Hanna was the lead researcher in a study that showed how further-modified iPS cells could be used to treat sickle-cell anemia in mice, the first proof of concept of the therapeutic application of iPS cells. Prof. Hanna has uncovered novel pathways regulating the reprogramming process and was the first to derive pristine “naïve” human pluripotent cells equivalent to those derived from mice and (i) can generate “cross-species humanized chimeric” mouse models that have human derived tissues (ii) can give rise to human primordial germ cell (progenitors of egg or sperm) or (iii) to all extra-embryonic compartments (placenta and yolk-sac). He was the first to expand prolonged periods of advanced and normal mammalian embryo development from pre-gastrulation until late organogenesis in an “artificial uterus” environment outside the maternal womb.  The latter platform enabled him to demonstrate the ability to be the first to generate advanced stage whole synthetic embryos made entirely from naïve pluripotent stem cells in the petri dish, that can complete gastrulation and demonstrate organ formation within adequate extra-embryonic compartments. In addition to demonstrating the power of cell reprogramming and ex utero synthetic advanced embryogenesis, his work offers the promise of powerful new research models for degenerative diseases, infertility, and modelling human early development.<br /><br />During his postdoctoral work, Prof. Hanna received a prestigious Novartis Fellowship from the Helen Hay Whitney Foundation. In 2010, he was awarded the Sir Charles Clore Prize for Outstanding Appointment in the Weizmann Institute. He received an EMBO young investigator award (2012), a Rappaport Prize in biomedical research (2013), a Krill Prize by the Wolf Foundation (2013), and the Helen and Martin Kimmel Award for Innovative Investigation (2014). In 2014, he was featured among “40 under 40” innovative scientists by the prestigious journal <em>Cell</em> and was elected as a member of EMBO in 2018. 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