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These programs are conducted by thousands of researchers from DOE’s 17 national laboratories, universities, and the private sector, and the results of this work provide broad benefits to society.</p><p>A distinctive feature of DOE’s biotechnology-related programs is their close coupling with the Department’s broad capabilities in the physical and computational sciences. For example:</p><ul><li>DOE’s world-leading capabilities at its X-ray and neutron sources are broadly used by researchers from industry to examine the structures of biomolecules for the development of pharmaceuticals.</li><li>DOE’s best-in-class high-performance computers are used to model complex biological systems to understand and harness processes to produce biofuels.</li><li>Capabilities for studying living systems and their genetic make-up are combined with automated “smart” laboratories and used to test these models and lay the groundwork for engineering these processes to optimize and scale-up biomanufacturing.</li><li>And scale-up infrastructure at DOE user-access facilities is leveraged to demonstrate bioproduction.</li></ul><p>In all of these activities, DOE maintains and immense store of well-curated, high-quality biological data that is made available to the scientific community.</p><p>In service of the Department’s science, applied energy, and national security mission set, the DOE ecosystem actively supports all aspects of biotechnology research, development, demonstration, and deployment, advancing innovations that serve the public good.</p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="layout blade-section--fullwidth blade-section--blue--dark blade-section blade-section--text--white" id="highlights"> <div class="blade-color " > <div class="grid-container"> <div class="grid-row"> <div class="grid-col"> <div class="block block-layout-builder block-inline-blocktemplate"> <div><div class="paragraph-reference-heading-wrapper paragraph-reference-heading-wrapper--"><h2 class="block block-layout-builder block-inline-blocktemplate"> Highlights </h2></div><div class="paragraph-reference-subheading-wrapper"><span>DOE research and development programs contribute to both advancing and safeguarding biotechnology, assuring the economic security and well-being of the nation. From discovery science to technology development, and from scale-up to first-of-kind deployments, DOE is pushing the frontier of biotechnology for science, applied energy, sustainability, and national security. Moreover, DOE’s unique and powerful scientific and technological capabilities are widely leveraged by other Federal government partners to support diverse mission spaces. </span></div></div> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--collection paragraph--view-mode--default"> <div class="paragraph__column"> <ul class="collection--cover-img collection"><li class="collection-item"> <article> <div class="collection-item--type-external-resource collection-item-wrapper"> <div class="collection-item__image"> </div> <div class="collection-item__icon"> <div class="fontawesome-icon"> <i class="fas fa-lightbulb" data-fa-transform="" data-fa-mask="" style=""></i> </div> </div> <div class="collection-item__title title-sm"> <a class="collection-item__link" href="https://science.osti.gov/ber/Research/bssd"> Understanding Biological Systems </a> </div> <div class="collection-item__summary"> <div class="field field--basic_string field--field_media_summary field field--name-field-media-summary field--type-string-long field--label-hidden field__item">DOE has supported discovery- and hypothesis-driven research, as well as technology development, to understand and enable the sustainable use of microbes, plants, and waste resources to produce sustainable fuels and chemicals to support national priorities in energy security and resilience. </div> </div> <div class="collection-item__date p2"> <time datetime="2024-11-19T15:11:26Z">November 19, 2024</time> </div> </div> </article> </li><li class="collection-item"> <article about="/eere/bioenergy/bioenergy-technologies-office"> <div class="collection-item--type-homepage collection-item-wrapper"> <div class="collection-item__image"> <div class="field field--media_thumbnail field--field_alternative_thumbnail field field--name-field-alternative-thumbnail field--type-entity-reference field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/full_article_width/public/2024-11/BETO%20Website%20Header%20Image_0.png?itok=V-bDbHCs" width="1350" height="901" alt="Algae in test tubes image" typeof="foaf:Image" /> </div> </div> <div class="collection-item__icon"> <div class="fontawesome-icon"> <i class="fas fa-lightbulb" data-fa-transform="" data-fa-mask="" style=""></i> </div> </div> <div class="collection-item__title title-sm"> <a class="collection-item__link" href="/eere/bioenergy/bioenergy-technologies-office"> <span class="field field--string field--title">Bioenergy Technologies Office</span> </a> </div> <div class="collection-item__date p2"> November 23, 2024 </div> </div> </article> </li><li class="collection-item"> <article> <div class="collection-item--type-external-resource collection-item-wrapper"> <div class="collection-item__image"> </div> <div class="collection-item__icon"> <div class="fontawesome-icon"> <i class="fas fa-lightbulb" data-fa-transform="" data-fa-mask="" style=""></i> </div> </div> <div class="collection-item__title title-sm"> <a class="collection-item__link" href="https://science.osti.gov/Initiatives/Biopreparedness"> Capabilities Contributing to Critical National Needs </a> </div> <div class="collection-item__summary"> <div class="field field--basic_string field--field_media_summary field field--name-field-media-summary field--type-string-long field--label-hidden field__item">The DOE complex’s unique capabilities are regularly marshaled in service of critical national needs, for example, to accelerate advances in precision diagnosis and treatment of cancer, or during the COVID-19 pandemic, when scientists and engineers from the DOE national laboratories coordinated to support development of all three vaccines approved for use in the U.S., as well as the life-saving COVID-19 antiviral, Paxlovid.</div> </div> <div class="collection-item__date p2"> <time datetime="2024-11-19T15:32:59Z">November 19, 2024</time> </div> </div> </article> </li></ul> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="layout blade-section--fullwidth blade-section--blue--dark blade-section blade-section--text--white" id="image-block"> <div class="blade-color " > <div class="grid-container"> <div class="grid-row"> <div > </div> </div> </div> </div> </section> <section class="layout blade-section--fullwidth blade-section--blue--dark blade-section blade-section--text--white" id="content-block"> <div class="blade-color " > <div class="grid-container"> <div class="grid-row"> <div class="grid-col"> <div class="block block-layout-builder block-inline-blocktemplate"> <div><div class="paragraph-reference-heading-wrapper paragraph-reference-heading-wrapper--"><h2 class="block block-layout-builder block-inline-blocktemplate"> Clean Fuels &amp; Products Earthshot </h2></div></div> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--two-column-image-and-text paragraph--view-mode--default"> <div class="grid-row grid-gap"> <div class=" tablet:grid-col-6 tablet:order-1 "> <img src="/sites/default/files/2024-11/AdobeStock_226347494_0.jpeg" alt="Planet Earth" class="width-full height-full object-fit-cover radius-lg" /> </div> <div class=" tablet:grid-col-6 tablet:padding-left-15 tablet:order-first"> <p class="title-2xl"></p> <div class="field field--text_default field--field_card_text field field--name-field-card-text field--type-text-long field--label-hidden field__item"><p>The climate crisis calls for a different kind of moonshot. DOE Energy Earthshots will accelerate breakthroughs of more abundant, affordable, and reliable clean energy solutions within the decade. They will drive the major innovation breakthroughs that we must achieve to solve the climate crisis, enable us to reach our national 2050 net-zero carbon goals, and create the jobs of the new clean energy economy. The Energy Earthshots target the most challenging technical problems across our energy economy.</p></div> </div> </div> </div> </div> </div> <div class="block block-layout-builder block-inline-blocktemplate"> <div></div> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--text-field paragraph--view-mode--default"> <div class="paragraph__column"> <div class="field field--text_default field--field_text field field--name-field-text field--type-text-long field--label-hidden field__item"><p>To significantly reduce the negative impacts of greenhouse gas emissions (GHGs) from carbon-based fuels and products critical to our way of life, DOE launched the Clean Fuels &amp; Products Shot. The Clean Fuels &amp; Products Shot focuses on decarbonizing fuels and chemicals through alternative sources of carbon to advance cost-effective technologies with a minimum of 85% lower GHG emissions by 2035.&nbsp;</p><p>The Clean Fuels &amp; Products Shot builds on DOE’s role in the <a href="/eere/bioenergy/sustainable-aviation-fuel-grand-challenge">Sustainable Aviation Fuel Grand Challenge</a> and supports the country’s goal of net-zero emissions by 2050 by developing the sustainable feedstocks and conversion technologies necessary to produce crucial fuels and carbon-based products in sectors that are difficult to fully decarbonize.&nbsp;</p></div> </div> </div> </div> <div class="template-block-button margin-y-4 display-flex flex-justify-center"> <a href="/eere/clean-fuels-products-shottm-alternative-sources-carbon-based-products" class="usa-button usa-button--outline">Learn More</a> </div> </div> </div> </div> </div> </div> </section> <section class="layout blade-section--fullwidth blade-section--blue--dark blade-section blade-section--text--white" id="podcast"> <div class="blade-color " > <div class="grid-container"> <div class="grid-row"> <div class="grid-col"> <div class="block block-layout-builder block-inline-blocktemplate"> <div><div class="paragraph-reference-heading-wrapper paragraph-reference-heading-wrapper--"><h2 class="block block-layout-builder block-inline-blocktemplate"> Progress, Potential, and Possibilities: Innovating with Biology Podcast </h2></div><div class="paragraph-reference-subheading-wrapper"><span>A DOE perspective on innovating with biology, and how biotechnology and biomanufacturing contribute to U.S. prosperity. </span></div></div> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--collection paragraph--view-mode--default"> <div class="paragraph__column"> <ul class="collection--img-text collection"><li class="collection-item"> <article> <div class="collection-item--type-external-resource collection-item-wrapper"> <div class="collection-item__image"> </div> <div class="collection-item__icon"> <div class="fontawesome-icon"> <i class="fas fa-lightbulb" data-fa-transform="" data-fa-mask="" style=""></i> </div> </div> <div class="collection-item__title title-sm"> <a class="collection-item__link" href="https://www.progresspotentialpossibilities.com/podcast/episode/7a1f2878/dr-valerie-sarisky-reed-phd-director-bioenergy-technologies-office-office-of-energy-efficiency-and-renewable-energy-us-department-of-energy-doe-bioenergy-innovation-for-the-us-bioeconomy"> Progress, Potential, and Possibilities: Innovating with Biology </a> </div> <div class="collection-item__summary"> </div> <div class="collection-item__button"> <a class="collection-item__link usa-button usa-button--outline" href="https://www.progresspotentialpossibilities.com/podcast/episode/7a1f2878/dr-valerie-sarisky-reed-phd-director-bioenergy-technologies-office-office-of-energy-efficiency-and-renewable-energy-us-department-of-energy-doe-bioenergy-innovation-for-the-us-bioeconomy"> Learn More <span class="usa-sr-only">about Progress, Potential, and Possibilities: Innovating with Biology </span> </a> </div> <div class="collection-item__date p2"> <time datetime="2024-11-15T17:37:46Z">November 15, 2024</time> </div> </div> </article> </li></ul> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="layout blade-section--fullwidth blade-section--blue--dark blade-section blade-section--text--white" id="feature"> <div class="blade-color " > <div class="grid-container"> <div class="grid-row"> <div class="grid-col"> <div class="block block-layout-builder block-inline-blocktemplate"> <div><div class="paragraph-reference-heading-wrapper paragraph-reference-heading-wrapper--"><h2 class="block block-layout-builder block-inline-blocktemplate"> The Future of Biofuels </h2></div></div> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--media paragraph--view-mode--default"> <div class="paragraph__column"> <div class="field field--entity_reference_entity_view field--field_media_embed field field--name-field-media-embed field--type-entity-reference field--label-hidden field__item"> <article class="article"> <div class="text-justify"> <div class="pbs-viral-player-wrapper" style="position: relative; 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