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</div> <style> #app_disp_styles { color: white; font: 15px arial; font-weight: 500; padding: 5px 6px; margin: 10px; width: 124px; background: #0b0988; z-index: 101; border-radius: 6px; left: 0; border: 5px solid #fff; border-style: outset; } .a_icon_android { background: #00b4ff; text-align: center; display: inline-block; padding: 6px 5px; border-radius: 5px; margin-left: 32px; } #target a { text-decoration: none; margin: 0 3px; } .a_icon_android span .fa { font-size: 30px; color: #fff; } .a_icon_apple { background: #f6941d; } </style> <div class="inner-page-banner-area ocm-banner"> <div class="container"> <div class="pagination-area"> <h1>OCM</h1> <div class="backrow cnt-head" style="color: #fff;" > <span class="con-location"> Feb 27-28, 2025  </span> <span class="con-location"> Paris, France</span> </div> <i><span class="edition-title cnt-head">11th World Congress on</span></i> <h1 class="main_title1 cnt-head" >Heart and Cardiovascular Diseases</h1> <ul> <li><a href="https://www.longdom.com/heartcongress">Home</a> -</li> <li>Ocm</li> </ul> </div> </div> </div>   <div class="speakers2-area bg-overlay-deep ocms-page"> <div class="container"> <h2 class="title-default-color">Organising Committee Members</h2> <div class="row speakers-wrapper-area"> <div class="col-md-2 col-sm-3 col-xs-12 speaker-img-box"> <a class="speakers-box2" data-toggle="modal" data-target="#speaker_5364"> <img src="https://s3.amazonaws.com/longdom/members/dr-john-695-3858-1313-5364.jpg" class="img-responsive" alt="speakers"> <div class="speakers-box-content"> <h3>John Richard Dylewski</h3>  </div>  </a> </div> <div class="modal fade modal-custom" id="speaker_5364" tabindex="-1" role="dialog" aria-labelledby="myModalLabel"> <div class="modal-dialog" role="document"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> <h4 class="modal-title" id="myModalLabel">Speaker Details</h4> </div> <div class="modal-body"> <div class="col-xs-4 padding-0"> <img src="https://s3.amazonaws.com/longdom/members/dr-john-695-3858-1313-5364.jpg" class="img-responsive" alt="speakers"> <div class="pop-speaker-block"> <h5>John Richard Dylewski</h5> <span></span> </div> </div> <div class="col-xs-8"> <p><p style="text-align:justify"><span style="font-size:16px"><span style="font-family:Times New Roman,Times,serif">John R. Dylewski, MD, FHRS, FACPAS  is a cardiac electro physiologist and professor of medicine in active clinical practice for the last 20+ years with an extensive and diversified background in materials engineering and medical applications of artificial intelligence to improve healthcare delivery. With the abundance of valuable data generated for patient care and the continuous production of scientific knowledge, Dr. Dylewski found it significantly challenging to deliver accurate, up-to-date and expeditious care to his tens of thousands of patients resulting in the development of the Complaint2Care model for a novel healthcare delivery platform, LifeSaver, powered by Apollo Artificial Intelligence. </span></span></p> </p> </div> <div class="col-xs-12"> </div> </div> <div class="clearfix"></div> </div> </div> </div> <div class="col-md-2 col-sm-3 col-xs-12 speaker-img-box"> <a class="speakers-box2" data-toggle="modal" data-target="#speaker_5365"> <img src="https://s3.amazonaws.com/longdom/members/steven-pic-1313-5365.png" class="img-responsive" alt="speakers"> <div class="speakers-box-content"> <h3>Steven J Adelman</h3>  </div>  </a> </div> <div class="modal fade modal-custom" id="speaker_5365" tabindex="-1" role="dialog" aria-labelledby="myModalLabel"> <div class="modal-dialog" role="document"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> <h4 class="modal-title" id="myModalLabel">Speaker Details</h4> </div> <div class="modal-body"> <div class="col-xs-4 padding-0"> <img src="https://s3.amazonaws.com/longdom/members/steven-pic-1313-5365.png" class="img-responsive" alt="speakers"> <div class="pop-speaker-block"> <h5>Steven J Adelman</h5> <span></span> </div> </div> <div class="col-xs-8"> <p><p style="text-align:justify"><span style="font-size:16px"><span style="font-family:Times New Roman,Times,serif">Steven J. Adelman, Founder and CEO of Vascular Strategies LLC, and CSO, NanoPhagix LLC has more than 25 years’ experience in drug discovery and development. Previously led several initiatives at Wyeth Pharmaceuticals: Senior Director, Cardiovascular and Metabolic Disease Research and Senior Director, Atherosclerosis CV/Women’s Health. Activities included identifying and validating discovery and development programs (small molecules and biologics), advancing more than 10 compounds through IND into clinical development. Expertise includes atherosclerosis and CVD, inflammation, immune biology, and women’s health. Worked extensively on rapamycin (sirolimus, Rapamune) for transplant indications and subsequent incorporation on the Cypher-stent, first successful drug-eluting coronary stent. Honors and memberships include elected Fellow American Heart Association; Golden Heart Member, Council on Arteriosclerosis, Thrombosis and Vascular Biology, Basic Sciences Council, Functional Genomics and Translational Biology Interdisciplinary Working Group, AHA, and International Atherosclerosis Society. Authored more than 100 articles and abstracts and holds over 30 patents.</span></span></p> <p style="text-align:justify"> </p> </p> </div> <div class="col-xs-12"> </div> </div> <div class="clearfix"></div> </div> </div> </div> <div class="col-md-2 col-sm-3 col-xs-12 speaker-img-box"> <a class="speakers-box2" data-toggle="modal" data-target="#speaker_5366"> <img src="https://s3.amazonaws.com/longdom/members/dipak-1313-5366.jpg" class="img-responsive" alt="speakers"> <div class="speakers-box-content"> <h3>Dipak P. Ramji</h3>  </div>  </a> </div> <div class="modal fade modal-custom" id="speaker_5366" tabindex="-1" role="dialog" aria-labelledby="myModalLabel"> <div class="modal-dialog" role="document"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> <h4 class="modal-title" id="myModalLabel">Speaker Details</h4> </div> <div class="modal-body"> <div class="col-xs-4 padding-0"> <img src="https://s3.amazonaws.com/longdom/members/dipak-1313-5366.jpg" class="img-responsive" alt="speakers"> <div class="pop-speaker-block"> <h5>Dipak P. Ramji</h5> <span></span> </div> </div> <div class="col-xs-8"> <p><p style="text-align:justify"><span style="font-size:16px"><span style="font-family:Times New Roman,Times,serif">Dipak Ramji is Professor of Cardiovascular Science and Deputy Head at the School of Biosciences in Cardiff University. He is also Fellow of the Learned Society of Wales. He received his BSc (Hons) degree (Biochemistry) and his PhD (Molecular Biology) from the University of Leeds. This was followed by post-doctoral research at EMBL (Heidelberg) and IRBM (Rome) with fellowships from the Royal Society and the EU. His current research is focused on understanding how natural products regulate cellular processes in heart disease with the goal of attaining deeper mechanistic insight and identifying preventative/therapeutic agents. He has published over 150 research articles (h index 41 and i10 index 76 with over 8350 citations), including 880-page book in 2022 on Methods in Atherosclerosis. He is an Editorial Board member of 16 international journals; regular organising committee member, speaker, and track/session chair at international conferences on heart disease; involved in grant evaluation for over 20 organisations; and supervised over 25 PhD students</span></span></p> </p> </div> <div class="col-xs-12"> </div> </div> <div class="clearfix"></div> </div> </div> </div> <div class="col-md-2 col-sm-3 col-xs-12 speaker-img-box"> <a class="speakers-box2" data-toggle="modal" data-target="#speaker_5367"> <img src="https://s3.amazonaws.com/longdom/members/john-k-maesaka-1287-5204-1313-5367.jpg" class="img-responsive" alt="speakers"> <div class="speakers-box-content"> <h3>John K Maesaka</h3>  </div>  </a> </div> <div class="modal fade modal-custom" id="speaker_5367" tabindex="-1" role="dialog" aria-labelledby="myModalLabel"> <div class="modal-dialog" role="document"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> <h4 class="modal-title" id="myModalLabel">Speaker Details</h4> </div> <div class="modal-body"> <div class="col-xs-4 padding-0"> <img src="https://s3.amazonaws.com/longdom/members/john-k-maesaka-1287-5204-1313-5367.jpg" class="img-responsive" alt="speakers"> <div class="pop-speaker-block"> <h5>John K Maesaka</h5> <span></span> </div> </div> <div class="col-xs-8"> <p><p style="text-align:justify"><span style="font-size:16px"><span style="font-family:Times New Roman,Times,serif">The approach to hyponatremia is in a state of flux, especially in differentiating syndrome of inappropriate secretion of antidiuretic hormone (SIADH) from cerebral-renal salt wasting (RSW) because of diametrically opposite therapeutic goals of water-restricting in SIADH and administering saline in RSW. We differentiated SIADH from RSW by utilizing an algorithm based on fractional excretion (FE) of urate and failure of isotonic saline infusions to dilute the urine or correct the hyponatremia  in SIADH as compared to excretion of dilute urines and correction of hyponatremia in RSW . We also identified the natriuretic factor we previously demonstrated in neurosurgical patients with RSW and in Alzheimer’s disease (AD).</span></span></p> <p style="text-align:justify"><span style="font-size:16px"><span style="font-family:Times New Roman,Times,serif"><strong>Results: </strong>Of 62 hyponatremic patients, (A) 17 patients (27%) had SIADH, 11 were nonresponsive to isotonic saline, and 5 normalized a previously high FEurate after correction of hyponatremia; (B) 19 patients (31%) had a reset osmostat based on normal FEurates and spontaneously excreted dilute urines; (C) 24 patients (38%) had RSW, 21 had no clinical evidence of cerebral disease, 19 had saline-induced dilute urines; 2, 10 required D5W to prevent rapid increases in serum sodium to prevent osmotic demyelination, 11 had persistently increased FEurate after correction of hyponatremia. (D) 1 patient had Addison disease with a low FEurate and (E) 1 patient (1.6%) had hyponatremia due to hydrochlorothiazide. We identified haptoglobin related protein without signal peptide (HPRWSP), the first potent inhibitor of proximal tubule sodium transport, as the natriuretic factor in a patient with RSW and in AD.</span></span></p> <p style="text-align:justify"><span style="font-size:16px"><span style="font-family:Times New Roman,Times,serif"><strong>Conclusions:</strong> RSW is much more common than is perceived with 21 of the 24 patients with RSW lacking evidence of cerebral disease, supporting our proposal to change cerebral salt wasting to RSW.   HPRWSP can serve as a biomarker for RSW to simplify diagnosis of RSW on first encounter, direct proper therapy, improve clinical outcomes and identifying a new syndrome of RSW in AD.  We will discuss how HPRWSP will more effectively treat congestive heart failure when combined with a distal diuretic.</span></span></p> </p> </div> <div class="col-xs-12"> </div> </div> <div class="clearfix"></div> </div> </div> </div> </div> </div> </div>  <style 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