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class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Autism"> <div class="vector-toc-text"> 1.4 Autism </div> </a> <ul id="toc-Autism-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Dementia_and_Alzheimer's_disease" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Dementia_and_Alzheimer's_disease"> <div class="vector-toc-text"> 1.5 Dementia and Alzheimer's disease </div> </a> <ul id="toc-Dementia_and_Alzheimer's_disease-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Comparison_table_of_efficacy" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Comparison_table_of_efficacy"> <div class="vector-toc-text"> 1.6 Comparison table of efficacy </div> </a> <ul id="toc-Comparison_table_of_efficacy-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Adverse_effects" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" 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class="vector-toc-link" href="#Sexual_side_effects"> <div class="vector-toc-text"> 2.3 Sexual side effects </div> </a> <ul id="toc-Sexual_side_effects-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Dementia" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Dementia"> <div class="vector-toc-text"> 2.4 Dementia </div> </a> <ul id="toc-Dementia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Drug-induced_OCD" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Drug-induced_OCD"> <div class="vector-toc-text"> 2.5 Drug-induced OCD </div> </a> <ul id="toc-Drug-induced_OCD-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Metabolism" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Metabolism"> <div class="vector-toc-text"> 2.6 Metabolism </div> </a> <ul id="toc-Metabolism-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Comparison_table_of_adverse_effects" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Comparison_table_of_adverse_effects"> <div class="vector-toc-text"> 2.7 Comparison table of adverse effects </div> </a> <ul id="toc-Comparison_table_of_adverse_effects-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Discontinuation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Discontinuation"> <div class="vector-toc-text"> 2.8 Discontinuation </div> </a> <ul id="toc-Discontinuation-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Pharmacology" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Pharmacology"> <div class="vector-toc-text"> 3 Pharmacology </div> </a> <button aria-controls="toc-Pharmacology-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Pharmacology subsection </button> <ul id="toc-Pharmacology-sublist" class="vector-toc-list"> <li id="toc-Pharmacodynamics" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Pharmacodynamics"> <div class="vector-toc-text"> 3.1 Pharmacodynamics </div> </a> <ul id="toc-Pharmacodynamics-sublist" class="vector-toc-list"> <li id="toc-Terms" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Terms"> <div class="vector-toc-text"> 3.1.1 Terms </div> </a> <ul id="toc-Terms-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Binding_profile" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Binding_profile"> <div class="vector-toc-text"> 3.2 Binding profile </div> </a> <ul id="toc-Binding_profile-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pharmacokinetics" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Pharmacokinetics"> <div class="vector-toc-text"> 3.3 Pharmacokinetics </div> </a> <ul id="toc-Pharmacokinetics-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-History" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#History"> <div class="vector-toc-text"> 4 History </div> </a> <ul id="toc-History-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Society_and_culture" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Society_and_culture"> <div class="vector-toc-text"> 5 Society and culture </div> </a> <button aria-controls="toc-Society_and_culture-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Society and culture subsection </button> <ul id="toc-Society_and_culture-sublist" class="vector-toc-list"> <li id="toc-Regulatory_status" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Regulatory_status"> <div class="vector-toc-text"> 5.1 Regulatory status </div> </a> <ul id="toc-Regulatory_status-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Notes" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Notes"> <div class="vector-toc-text"> 6 Notes </div> </a> <ul id="toc-Notes-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> 7 See also </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> 8 References </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> 9 Further reading </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> 10 External links </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button 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Available in 22 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-22" aria-hidden="true" > 22 languages </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%85%D8%B6%D8%A7%D8%AF_%D8%BA%D9%8A%D8%B1_%D9%86%D9%85%D8%B7%D9%8A_%D9%84%D9%84%D8%B0%D9%87%D8%A7%D9%86" title="مضاد غير نمطي للذهان – Arabic" lang="ar" hreflang="ar" data-title="مضاد غير نمطي للذهان" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target">العربية</a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Antipsic%C3%B2tic_at%C3%ADpic" title="Antipsicòtic atípic – Catalan" lang="ca" hreflang="ca" data-title="Antipsicòtic atípic" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target">Català</a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Atypisches_Neuroleptikum" title="Atypisches Neuroleptikum – German" lang="de" hreflang="de" data-title="Atypisches Neuroleptikum" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target">Deutsch</a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Antipsic%C3%B3tico_at%C3%ADpico" title="Antipsicótico atípico – Spanish" lang="es" hreflang="es" data-title="Antipsicótico atípico" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target">Español</a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A2%D9%86%D8%AA%DB%8C%E2%80%8C%D8%B3%D8%A7%DB%8C%DA%A9%D9%88%D8%AA%DB%8C%DA%A9_%D8%A2%D8%AA%DB%8C%D9%BE%DB%8C%DA%A9%D8%A7%D9%84" title="آنتی‌سایکوتیک آتیپیکال – Persian" lang="fa" hreflang="fa" data-title="آنتی‌سایکوتیک آتیپیکال" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target">فارسی</a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Antipsychotique_atypique" title="Antipsychotique atypique – French" lang="fr" hreflang="fr" data-title="Antipsychotique atypique" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target">Français</a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%B9%84%EC%A0%95%ED%98%95%EC%A0%81_%ED%95%AD%EC%A0%95%EC%8B%A0%EB%B3%91%EC%A0%9C%EC%A0%9C" title="비정형적 항정신병제제 – Korean" lang="ko" hreflang="ko" data-title="비정형적 항정신병제제" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target">한국어</a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Antipsicotico_atipico" title="Antipsicotico atipico – Italian" lang="it" hreflang="it" data-title="Antipsicotico atipico" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target">Italiano</a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%AA%D7%A8%D7%95%D7%A4%D7%95%D7%AA_%D7%90%D7%A0%D7%98%D7%99-%D7%A4%D7%A1%D7%99%D7%9B%D7%95%D7%98%D7%99%D7%95%D7%AA_%D7%9C%D7%90_%D7%98%D7%99%D7%A4%D7%95%D7%A1%D7%99%D7%95%D7%AA" title="תרופות אנטי-פסיכוטיות לא טיפוסיות – Hebrew" lang="he" hreflang="he" data-title="תרופות אנטי-פסיכוטיות לא טיפוסיות" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target">עברית</a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Atypische_antipsychotica" title="Atypische antipsychotica – Dutch" lang="nl" hreflang="nl" data-title="Atypische antipsychotica" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target">Nederlands</a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E9%9D%9E%E5%AE%9A%E5%9E%8B%E6%8A%97%E7%B2%BE%E7%A5%9E%E7%97%85%E8%96%AC" title="非定型抗精神病薬 – Japanese" lang="ja" hreflang="ja" data-title="非定型抗精神病薬" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target">日本語</a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%8F%E0%AC%9F%E0%AC%BF%E0%AC%AA%E0%AC%BF%E0%AC%95%E0%AC%BE%E0%AC%B2%E0%AD%8D_%E0%AC%86%E0%AC%A3%E0%AD%8D%E0%AC%9F%E0%AC%BF%E0%AC%B8%E0%AC%BE%E0%AC%87%E0%AC%95%E0%AD%8B%E0%AC%9F%E0%AC%BF%E0%AC%95" title="ଏଟିପିକାଲ୍ ଆଣ୍ଟିସାଇକୋଟିକ – Odia" lang="or" hreflang="or" data-title="ଏଟିପିକାଲ୍ ଆଣ୍ଟିସାଇକୋଟିକ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target">ଓଡ଼ିଆ</a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Antipsic%C3%B3tico_at%C3%ADpico" title="Antipsicótico atípico – Portuguese" lang="pt" hreflang="pt" data-title="Antipsicótico atípico" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target">Português</a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Antipsihotic_atipic" title="Antipsihotic atipic – Romanian" lang="ro" hreflang="ro" data-title="Antipsihotic atipic" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target">Română</a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%90%D1%82%D0%B8%D0%BF%D0%B8%D1%87%D0%BD%D1%8B%D0%B5_%D0%B0%D0%BD%D1%82%D0%B8%D0%BF%D1%81%D0%B8%D1%85%D0%BE%D1%82%D0%B8%D0%BA%D0%B8" title="Атипичные антипсихотики – Russian" lang="ru" hreflang="ru" data-title="Атипичные антипсихотики" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target">Русский</a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Atypical_antipsychotic" title="Atypical antipsychotic – Simple English" lang="en-simple" hreflang="en-simple" data-title="Atypical antipsychotic" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target">Simple English</a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Atipi%C4%8Dni_antipsihotik" title="Atipični antipsihotik – Serbian" lang="sr" hreflang="sr" data-title="Atipični antipsihotik" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target">Српски / srpski</a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Atipi%C4%8Dni_antipsihotik" title="Atipični antipsihotik – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Atipični antipsihotik" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target">Srpskohrvatski / српскохрватски</a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Atypiska_antipsykotika" title="Atypiska antipsykotika – Swedish" lang="sv" hreflang="sv" data-title="Atypiska antipsykotika" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target">Svenska</a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Atipik_antipsikotik" title="Atipik antipsikotik – Turkish" lang="tr" hreflang="tr" data-title="Atipik antipsikotik" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target">Türkçe</a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Thu%E1%BB%91c_ch%E1%BB%91ng_lo%E1%BA%A1n_th%E1%BA%A7n_kh%C3%B4ng_%C4%91i%E1%BB%83n_h%C3%ACnh" title="Thuốc chống loạn thần không điển hình – Vietnamese" lang="vi" hreflang="vi" data-title="Thuốc chống loạn thần không điển hình" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target">Tiếng Việt</a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E9%9D%9E%E5%85%B8%E5%9E%8B%E6%8A%97%E7%B2%BE%E7%A5%9E%E7%97%85%E8%97%A5%E7%89%A9" title="非典型抗精神病藥物 – Chinese" lang="zh" hreflang="zh" data-title="非典型抗精神病藥物" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target">中文</a></li> </ul> <div class="after-portlet after-portlet-lang"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q758295#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Atypical_antipsychotic" title="View the content page [c]" accesskey="c">Article</a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:Atypical_antipsychotic" rel="discussion" title="Discuss improvements to the content page [t]" 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data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above" style="background-color: #ddbbee">Atypical antipsychotic</th></tr><tr><td colspan="2" class="infobox-subheader"><a href="/wiki/Drug_class" title="Drug class">Drug class</a></td></tr><tr><td colspan="2" class="infobox-image"><a href="/wiki/File:Clozapine.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/32/Clozapine.svg/330px-Clozapine.svg.png" decoding="async" width="280" height="264" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/32/Clozapine.svg/500px-Clozapine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/32/Clozapine.svg/560px-Clozapine.svg.png 2x" data-file-width="512" data-file-height="483" /></a><div class="infobox-caption"><a href="/wiki/Skeletal_formula" title="Skeletal formula">Skeletal formula</a> of <a href="/wiki/Clozapine" title="Clozapine">clozapine</a>, the first atypical antipsychotic (1972)</div></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Synonym" title="Synonym">Synonyms</a></th><td class="infobox-data">Second generation antipsychotic, serotonin–dopamine antagonist</td></tr><tr><th colspan="2" class="infobox-header" style="background: #e8e8e8;">Legal status</th></tr><tr><td colspan="2" class="infobox-below" style="background: #e8e8e8; text-align: center"><a href="https://www.wikidata.org/wiki/Q758295" class="extiw" title="d:Q758295">In Wikidata</a></td></tr></tbody></table> The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and <a href="/wiki/Serotonin" title="Serotonin">serotonin</a>–dopamine antagonists (SDAs),<a href="#cite_note-Miyake-1">[1]</a><a href="#cite_note-2">[2]</a> are a group of <a href="/wiki/Antipsychotic" title="Antipsychotic">antipsychotic</a> drugs (antipsychotic drugs in general are also known as <a href="/wiki/Tranquilizer" class="mw-redirect" title="Tranquilizer">tranquilizers</a> and <a href="/wiki/Neuroleptic" class="mw-redirect" title="Neuroleptic">neuroleptics</a>, although the latter is usually reserved for the <a href="/wiki/Typical_antipsychotics" class="mw-redirect" title="Typical antipsychotics">typical antipsychotics</a>) largely introduced after the 1970s and used to treat psychiatric conditions. Some atypical antipsychotics have received regulatory approval (e.g. by the <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">FDA</a> of the <a href="/wiki/United_States_of_America" class="mw-redirect" title="United States of America">US</a>, the <a href="/wiki/Therapeutic_Goods_Administration" title="Therapeutic Goods Administration">TGA</a> of <a href="/wiki/Australia" title="Australia">Australia</a>, the <a href="/wiki/Medicines_and_Healthcare_products_Regulatory_Agency" title="Medicines and Healthcare products Regulatory Agency">MHRA</a> of the <a href="/wiki/United_Kingdom" title="United Kingdom">UK</a>) for <a href="/wiki/Schizophrenia" title="Schizophrenia">schizophrenia</a>, <a href="/wiki/Bipolar_disorder" title="Bipolar disorder">bipolar disorder</a>, irritability in <a href="/wiki/Autism" title="Autism">autism</a>, and as an <a href="/wiki/Adjuvant_therapy" title="Adjuvant therapy">adjunct</a> in <a href="/wiki/Major_depressive_disorder" title="Major depressive disorder">major depressive disorder</a>. Both generations of medication tend to block receptors in the brain's <a href="/wiki/Dopamine_pathways" class="mw-redirect" title="Dopamine pathways">dopamine pathways</a>. Atypicals are less likely than <a href="/wiki/Haloperidol" title="Haloperidol">haloperidol</a>—the most widely used <a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">typical antipsychotic</a>—to cause <a href="/wiki/Extrapyramidal_symptom" class="mw-redirect" title="Extrapyramidal symptom">extrapyramidal</a> <a href="/wiki/Motor_control" title="Motor control">motor control</a> <a href="/wiki/Disabilities" class="mw-redirect" title="Disabilities">disabilities</a> in patients such as unsteady <a href="/wiki/Parkinson%27s_disease" title="Parkinson's disease">Parkinson's disease</a>–type movements, body <a href="/wiki/Rigidity_(neurology)" class="mw-redirect" title="Rigidity (neurology)">rigidity</a>, and involuntary <a href="/wiki/Tremor" title="Tremor">tremors</a>. However, only a few of the atypicals have been demonstrated to be superior to lesser-used, low-<a href="/wiki/Potency_(pharmacology)" title="Potency (pharmacology)">potency</a> first-generation antipsychotics in this regard.<a href="#cite_note-leucht-3">[3]</a><a href="#cite_note-Leucht_2013-4">[4]</a><a href="#cite_note-5">[5]</a> As experience with these agents has grown, several studies have questioned the utility of broadly characterizing antipsychotic drugs as "atypical/second generation" as opposed to "first generation", noting that each agent has its own efficacy and side-effect profile. It has been argued that a more nuanced view in which the needs of individual patients are matched to the properties of individual drugs is more appropriate.<a href="#cite_note-Leucht_2013-4">[4]</a><a href="#cite_note-leucht-3">[3]</a> Although atypical antipsychotics are thought to be safer than typical antipsychotics, they still have severe side effects, including <a href="/wiki/Tardive_dyskinesia" title="Tardive dyskinesia">tardive dyskinesia</a> (a serious movement disorder), <a href="/wiki/Neuroleptic_malignant_syndrome" title="Neuroleptic malignant syndrome">neuroleptic malignant syndrome</a>, and increased risk of <a href="/wiki/Stroke" title="Stroke">stroke</a>, <a href="/wiki/Sudden_Cardiac_Death" class="mw-redirect" title="Sudden Cardiac Death">sudden cardiac death</a>, <a href="/wiki/Thrombus" title="Thrombus">blood clots</a>, and <a href="/wiki/Diabetes" title="Diabetes">diabetes</a>. <a href="/wiki/Obesity" title="Obesity">Significant weight gain</a> may occur. Critics have argued that "the time has come to abandon the terms first-generation and second-generation antipsychotics, as they do not merit this distinction."<a href="#cite_note-6">[6]</a> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=1" title="Edit section: Medical uses">edit</a>]</div> Atypical antipsychotics are typically used to treat <a href="/wiki/Schizophrenia" title="Schizophrenia">schizophrenia</a> or <a href="/wiki/Bipolar_disorder" title="Bipolar disorder">bipolar disorder</a>.<a href="#cite_note-AHFS-7">[7]</a> They are also frequently used to treat <a href="/wiki/Psychomotor_agitation" title="Psychomotor agitation">agitation</a> associated with <a href="/wiki/Dementia" title="Dementia">dementia</a>, <a href="/wiki/Anxiety_disorder" title="Anxiety disorder">anxiety disorder</a>, <a href="/wiki/Autism_spectrum_disorder" class="mw-redirect" title="Autism spectrum disorder">autism spectrum disorder</a>, <a href="/wiki/Persecutory_delusion" title="Persecutory delusion">persecutory delusion</a> and <a href="/wiki/Obsessive-compulsive_disorder" class="mw-redirect" title="Obsessive-compulsive disorder">obsessive-compulsive disorder</a> (an <a href="/wiki/Off-label_use" title="Off-label use">off-label use</a>).<a href="#cite_note-Off11-8">[8]</a><a href="#cite_note-9">[9]</a> In dementia, they should only be considered after other treatments have failed and if the patient is a risk to themselves and/or others.<a href="#cite_note-10">[10]</a> <div class="mw-heading mw-heading3"><h3 id="Schizophrenia">Schizophrenia</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=2" title="Edit section: Schizophrenia">edit</a>]</div> The first-line psychiatric treatment for schizophrenia is antipsychotic medication,<a href="#cite_note-fn_72-11">[11]</a> which can reduce the positive symptoms of schizophrenia in about 8–15 days. Antipsychotics only appear to improve secondary <a href="/wiki/Negative_symptoms" class="mw-redirect" title="Negative symptoms">negative symptoms</a> of schizophrenia in the short term and may worsen negative symptoms overall.<a href="#cite_note-12">[12]</a> Overall there is no good evidence that atypical antipsychotics have any therapeutic benefit for treating the negative symptoms of schizophrenia.<a href="#cite_note-pmc4466178-13">[13]</a> There is very little evidence on which to base a risk and benefit assessment of using antipsychotics for long-term treatment.<a href="#cite_note-pmid27802977-14">[14]</a> The choice of which antipsychotic to use for a specific patient is based on benefits, risks, and costs.<a href="#cite_note-Lancet09-15">[15]</a> It is debatable whether, as a class, <a href="/wiki/Typical_antipsychotics" class="mw-redirect" title="Typical antipsychotics">typical</a> or atypical antipsychotics are better.<a href="#cite_note-16">[16]</a> Both have equal drop-out and symptom relapse rates when typicals are used at low to moderate dosages.<a href="#cite_note-AFP07-17">[17]</a> There is a good response in 40–50% of patients, a partial response in 30–40%, and treatment resistance (failure of symptoms to respond satisfactorily after six weeks to two of three different antipsychotics) in the remaining 20%.<a href="#cite_note-AFP10-18">[18]</a> <a href="/wiki/Clozapine" title="Clozapine">Clozapine</a> is considered a first choice treatment for <a href="/wiki/Treatment_resistant_schizophrenia" class="mw-redirect" title="Treatment resistant schizophrenia">treatment resistant schizophrenia</a>, especially in the short term; in the longer-terms the risks of adverse effects complicate the choice.<a href="#cite_note-refac-19">[19]</a> In turn, risperidone, olanzapine, and <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a> have been recommended for the treatment of first-episode psychosis.<a href="#cite_note-20">[20]</a><a href="#cite_note-21">[21]</a> <div class="mw-heading mw-heading4"><h4 id="Efficacy_in_the_treatment_of_schizophrenia">Efficacy in the treatment of schizophrenia</h4>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=3" title="Edit section: Efficacy in the treatment of schizophrenia">edit</a>]</div> The utility of broadly grouping the antipsychotics into first generation and atypical categories has been challenged. It has been argued that a more nuanced view, matching the properties of individual drugs to the needs of specific patients is preferable.<a href="#cite_note-leucht-3">[3]</a> While the atypical (second-generation) antipsychotics were marketed as offering greater efficacy in reducing psychotic symptoms while reducing side effects (and <a href="/wiki/Extrapyramidal_symptoms" title="Extrapyramidal symptoms">extrapyramidal symptoms</a> in particular) than typical medications, the results showing these effects often lacked robustness, and the assumption was increasingly challenged even as atypical prescriptions were soaring.<a href="#cite_note-22">[22]</a><a href="#cite_note-23">[23]</a> In 2005 the US government body <a href="/wiki/National_Institute_of_Mental_Health" title="National Institute of Mental Health">NIMH</a> published the results of a major independent (not funded by the pharmaceutical companies) multi-site, double-blind study (the CATIE project).<a href="#cite_note-24">[24]</a> This study compared several atypical antipsychotics to an older, mid-potency typical antipsychotic, <a href="/wiki/Perphenazine" title="Perphenazine">perphenazine</a>, among 1,493 persons with schizophrenia. The study found that only <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a> outperformed perphenazine in discontinuation rate (the rate at which people stopped taking it due to its effects). The authors noted an apparent superior efficacy of olanzapine to the other drugs in terms of reduction in psychopathology and rate of hospitalizations, but olanzapine was associated with relatively severe <a href="/wiki/Metabolism" title="Metabolism">metabolic</a> effects such as a major weight gain problem (averaging 9.4 lbs over 18 months) and increases in <a href="/wiki/Blood_glucose" class="mw-redirect" title="Blood glucose">glucose</a>, <a href="/wiki/Blood_cholesterol_level" class="mw-redirect" title="Blood cholesterol level">cholesterol</a>, and <a href="/wiki/Triglyceride" title="Triglyceride">triglycerides</a>. No other atypical studied (<a href="/wiki/Risperidone" title="Risperidone">risperidone</a>, <a href="/wiki/Quetiapine" title="Quetiapine">quetiapine</a>, and <a href="/wiki/Ziprasidone" title="Ziprasidone">ziprasidone</a>) did better than the typical perphenazine on the measures used, nor did they produce fewer adverse effects than the typical antipsychotic perphenazine (a result supported by a meta-analysis<a href="#cite_note-leucht-3">[3]</a> by Leucht et al. published in <a href="/wiki/The_Lancet" title="The Lancet">The Lancet</a>), although more patients discontinued perphenazine owing to extrapyramidal effects compared to the atypical agents (8% vs. 2% to 4%, P=0.002). A phase 2 part of this CATIE study roughly replicated these findings.<a href="#cite_note-25">[25]</a> Compliance has not been shown to be different between the two types.<a href="#cite_note-26">[26]</a> Overall evaluations of the CATIE and other studies have led many researchers to question the first-line prescribing of atypicals over typicals, or even to question the distinction between the two classes.<a href="#cite_note-27">[27]</a><a href="#cite_note-28">[28]</a><a href="#cite_note-29">[29]</a> It has been suggested that there is no validity to the term "second-generation antipsychotic drugs" and that the drugs that currently occupy this category are not identical to each other in mechanism, efficacy, and side-effect profiles.<a href="#cite_note-30">[30]</a> Each drug has its own mechanism, as Dr. Rif S. El-Mallakh, explained regarding the binding site and occupancy with a focus on the dopamine D2 receptor:<blockquote>In general, when an antagonist of a neurotransmitter receptor is used, it must occupy a minimum of 65% to 70% of the target receptor to be effective. This is clearly the case when the target is a postsynaptic receptor, such as the dopamine D2 receptor. Similarly, despite significant variability in antidepressant response, blockade of 65% to 80% of presynaptic transport proteins—such as the serotonin reuptake pumps when considering serotoninergic antidepressants, or the norepinephrine reuptake pumps when considering noradrenergic agents such as nortriptyline—is necessary for these medications to be effective.... Depending on the level of intrinsic activity of a partial agonist and clinical goal, the clinician may aim for a different level of receptor occupancy. For example, <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a> will act as a dopamine agonist at lower concentrations, but blocks the receptor at higher concentrations. Unlike antagonist antipsychotics, which require only 65% to 70% D2 <a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">receptor occupancy</a> to be effective, aripiprazole receptor binding at effective antipsychotic doses is 90% to 95%. Since aripiprazole has an intrinsic activity of approximately 30% (i.e., when it binds, it stimulates the D2 receptor to about 30% of the effect of dopamine binding to the receptor), binding to 90% of the receptors, and displacing endogenous dopamine, allows aripiprazole to replace the background or tonic tone of dopamine, which has been measured at 19% in people with schizophrenia and 9% in controls. Clinically, this still appears as the minimal effective dose achieving maximal response without significant parkinsonism despite >90% receptor occupancy.<a href="#cite_note-31">[31]</a></blockquote> <div class="mw-heading mw-heading3"><h3 id="Bipolar_disorder">Bipolar disorder</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=4" title="Edit section: Bipolar disorder">edit</a>]</div> In bipolar disorder, SGAs are most commonly used to rapidly control <a href="/wiki/Mania" title="Mania">acute mania</a> and <a href="/wiki/Mixed_episodes" class="mw-redirect" title="Mixed episodes">mixed episodes</a>, often in conjunction with mood stabilizers (which tend to have a delayed onset of action in such cases) such as <a href="/wiki/Lithium_(medication)" title="Lithium (medication)">lithium</a> and <a href="/wiki/Sodium_valproate" class="mw-redirect" title="Sodium valproate">valproate</a>. In milder cases of mania or mixed episodes, mood stabilizer monotherapy may be attempted first.<a href="#cite_note-Maudsley-32">[32]</a> SGAs are also used to treat other aspects of the disorder (such as acute bipolar depression or as a prophylactic treatment) as adjuncts or as a monotherapy, depending on the drug. Both <a href="/wiki/Quetiapine" title="Quetiapine">quetiapine</a> and <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a> have demonstrated significant efficacy in all three treatment phases of bipolar disorder. <a href="/wiki/Lurasidone" title="Lurasidone">Lurasidone</a> (trade name Latuda) has demonstrated some efficacy in the acute depressive phase of bipolar disorder.<a href="#cite_note-Maudsley-32">[32]</a><a href="#cite_note-33">[33]</a><a href="#cite_note-UpToDateBPMT-34">[34]</a> <div class="mw-heading mw-heading3"><h3 id="Major_depressive_disorder">Major depressive disorder</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=5" title="Edit section: Major depressive disorder">edit</a>]</div> In non-psychotic <a href="/wiki/Major_depressive_disorder" title="Major depressive disorder">major depressive disorder</a> (MDD), some SGAs have demonstrated significant efficacy as adjunctive agents; and, such agents include:<a href="#cite_note-Coch-35">[35]</a><a href="#cite_note-pmid23554581-36">[36]</a><a href="#cite_note-AmJPsych-37">[37]</a><a href="#cite_note-38">[38]</a> <ul><li><a href="/wiki/Aripiprazole" title="Aripiprazole">Aripiprazole</a></li> <li><a href="/wiki/Brexpiprazole" title="Brexpiprazole">Brexpiprazole</a></li> <li><a href="/wiki/Cariprazine" title="Cariprazine">Cariprazine</a></li> <li><a href="/wiki/Olanzapine" title="Olanzapine">Olanzapine</a></li> <li><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a></li> <li><a href="/wiki/Ziprasidone" title="Ziprasidone">Ziprasidone</a><a href="#cite_note-39">[39]</a></li></ul> whereas only quetiapine has demonstrated efficacy as a monotherapy in non-psychotic MDD.<a href="#cite_note-40">[40]</a> <a href="/wiki/Olanzapine/fluoxetine" title="Olanzapine/fluoxetine">Olanzapine/fluoxetine</a> is an efficacious treatment in both psychotic and non-psychotic MDD.<a href="#cite_note-DD-41">[41]</a><a href="#cite_note-42">[42]</a> <a href="/wiki/Aripiprazole" title="Aripiprazole">Aripiprazole</a>, <a href="/wiki/Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>, <a href="/wiki/Cariprazine" title="Cariprazine">cariprazine</a>, <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a>, and <a href="/wiki/Quetiapine" title="Quetiapine">quetiapine</a> have been approved as adjunct treatment for MDD by the FDA in the United States.<a href="#cite_note-pmid25963405-43">[43]</a><a href="#cite_note-44">[44]</a> <a href="/wiki/Cariprazine" title="Cariprazine">Cariprazine</a>, <a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a>, <a href="/wiki/Lurasidone" title="Lurasidone">lurasidone</a>, and <a href="/wiki/Lumateperone" title="Lumateperone">lumateperone</a><a href="#cite_note-45">[45]</a> have been approved, as monotherapies, for <a href="/wiki/Bipolar_depression" class="mw-redirect" title="Bipolar depression">bipolar depression</a>, but as of present, lurasidone has not been approved for MDD.<a href="#cite_note-pmid25963405-43">[43]</a> <div class="mw-heading mw-heading3"><h3 id="Autism">Autism</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=6" title="Edit section: Autism">edit</a>]</div> Both <a href="/wiki/Risperidone" title="Risperidone">risperidone</a> and <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a> have received FDA approval for irritability in autism.<a href="#cite_note-DD-41">[41]</a> <div class="mw-heading mw-heading3"><h3 id="Dementia_and_Alzheimer's_disease">Dementia and Alzheimer's disease</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=7" title="Edit section: Dementia and Alzheimer's disease">edit</a>]</div> Between May 2007 and April 2008, Dementia and Alzheimer's together accounted for 28% of atypical antipsychotic use in patients aged 65 or older.<a href="#cite_note-pmid19727265-46">[46]</a> The U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> requires that all atypical antipsychotics carry a <a href="/wiki/Boxed_warning" title="Boxed warning">black box warning</a> that the medication has been associated with an increased risk of mortality in elderly patients.<a href="#cite_note-pmid19727265-46">[46]</a> In 2005, the FDA issued an advisory warning of an increased risk of death when atypical antipsychotics are used in dementia.<a href="#cite_note-pmid21191528-47">[47]</a> In the subsequent 5 years, the use of atypical antipsychotics to treat dementia decreased by nearly 50%.<a href="#cite_note-pmid21191528-47">[47]</a> As of now, the only FDA-approved atypical antipsychotic for alzheimer-related dementia is <a href="/wiki/Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>. <div class="mw-heading mw-heading3"><h3 id="Comparison_table_of_efficacy">Comparison table of efficacy</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=8" title="Edit section: Comparison table of efficacy">edit</a>]</div> <table class="wikitable collapsible collapsed" style="width:100%;"> <tbody><tr> <th colspan="6">Relative efficacy of SGAs </th></tr> <tr> <th>Generic Drug Name<a href="#cite_note-Coch-35">[35]</a><a href="#cite_note-pmid23554581-36">[36]</a><a href="#cite_note-48">[48]</a><a href="#cite_note-Leucht_2013-4">[4]</a><a href="#cite_note-pmc2762364-49">[49]</a></th> <th>Schizophrenia</th> <th>Mania</th> <th>Bipolar Maintenance</th> <th>Bipolar Depression</th> <th>Adjunct in Major Depressive Disorder </th></tr> <tr> <td><a href="/wiki/Amisulpride" title="Amisulpride">Amisulpride</a></td> <td>+++</td> <td>?</td> <td>?</td> <td>?</td> <td>? (+++ as a dysthymia monotherapy, however) </td></tr> <tr> <td><a href="/wiki/Aripiprazole" title="Aripiprazole">Aripiprazole</a></td> <td>++</td> <td>++</td> <td>++/+</td> <td>-<a href="#cite_note-BPD-50">[50]</a></td> <td>+++ </td></tr> <tr> <td><a href="/wiki/Asenapine" title="Asenapine">Asenapine</a></td> <td>+++</td> <td>++</td> <td>++</td> <td>? (some evidence has suggested efficacy in treating depressive symptoms in mixed/manic episodes<a href="#cite_note-51">[51]</a>)</td> <td>? </td></tr> <tr> <td><a href="/wiki/Blonanserin" title="Blonanserin">Blonanserin</a></td> <td>++</td> <td>?</td> <td>?</td> <td>?</td> <td>? </td></tr> <tr> <td><a href="/wiki/Cariprazine" title="Cariprazine">Cariprazine</a></td> <td>+++</td> <td>?</td> <td>?</td> <td>?</td> <td>? </td></tr> <tr> <td><a href="/wiki/Clozapine" title="Clozapine">Clozapine</a></td> <td>+++</td> <td>+++</td> <td>+++</td> <td>+++</td> <td>? </td></tr> <tr> <td><a href="/wiki/Iloperidone" title="Iloperidone">Iloperidone</a></td> <td>+</td> <td>?</td> <td>?</td> <td>?</td> <td>? </td></tr> <tr> <td><a href="/wiki/Lurasidone" title="Lurasidone">Lurasidone</a></td> <td>+</td> <td>?</td> <td>?</td> <td>+++<a href="#cite_note-BPD-50">[50]</a></td> <td>? </td></tr> <tr> <td><a href="/wiki/Melperone" title="Melperone">Melperone</a></td> <td>+++/++</td> <td>?</td> <td>?</td> <td>?</td> <td>? </td></tr> <tr> <td><a href="/wiki/Olanzapine" title="Olanzapine">Olanzapine</a></td> <td>+++</td> <td>+++</td> <td>++</td> <td>+++/++ (+++ when combined with fluoxetine)<a href="#cite_note-BPD-50">[50]</a></td> <td>++ </td></tr> <tr> <td><a href="/wiki/Paliperidone" title="Paliperidone">Paliperidone</a></td> <td>++</td> <td>?</td> <td>?</td> <td>?</td> <td>? </td></tr> <tr> <td><a href="/wiki/Perospirone" title="Perospirone">Perospirone</a><a href="#cite_note-52">[52]</a></td> <td>+</td> <td>?</td> <td>?</td> <td>?</td> <td>? </td></tr> <tr> <td><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a></td> <td>++</td> <td>++</td> <td>+++</td> <td>++<a href="#cite_note-BPD-50">[50]</a></td> <td>++ </td></tr> <tr> <td><a href="/wiki/Risperidone" title="Risperidone">Risperidone</a></td> <td>+++</td> <td>+++</td> <td>++</td> <td>-<a href="#cite_note-BPD-50">[50]</a></td> <td>+ </td></tr> <tr> <td><a href="/wiki/Sertindole" title="Sertindole">Sertindole</a></td> <td>++</td> <td>?</td> <td>?</td> <td>?</td> <td>? </td></tr> <tr> <td><a href="/wiki/Ziprasidone" title="Ziprasidone">Ziprasidone</a></td> <td>++/+</td> <td>++/+</td> <td>?</td> <td>-<a href="#cite_note-BPD-50">[50]</a></td> <td>? </td></tr> <tr> <td><a href="/wiki/Zotepine" title="Zotepine">Zotepine</a></td> <td>++</td> <td>?</td> <td>?</td> <td>?</td> <td>? </td></tr> <tr> <td colspan="6"> Legend: <dl><dd>- Inefficacious</dd> <dd>+ Less effective than most treatments, but still with some efficacy.</dd> <dd>++ Standard, in terms of efficacy, treatment. No convincing evidence to say it is superior to other standard treatments.</dd> <dd>+++ Very efficacious agent. The efficacy of this treatment in the indication in question has been proven to be significantly greater than many other treatments.</dd></dl> </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Adverse_effects">Adverse effects</h2>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=9" title="Edit section: Adverse effects">edit</a>]</div> The side effects reportedly associated with the various atypical antipsychotics vary and are medication-specific. <div class="mw-heading mw-heading3"><h3 id="Tardive_dyskinesia">Tardive dyskinesia</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=10" title="Edit section: Tardive dyskinesia">edit</a>]</div> Both typical and atypical antipsychotics can cause tardive dyskinesia.<a href="#cite_note-TD08-53">[53]</a> According to one study, rates are lower with the atypicals at 3.9% per year as opposed to the typicals at 5.5% per year.<a href="#cite_note-TD08-53">[53]</a> However, tardive dyskinesia typically develops after long-term (possibly decades) use of antipsychotics. It is not clear if atypical antipsychotics, having been in use for a relatively short time, produce a lower incidence of tardive dyskinesia.<a href="#cite_note-Maudsley-32">[32]</a><a href="#cite_note-UpToDateSchiz-54">[54]</a> One hypothesis as to why atypicals have a lower risk of tardive dyskinesia is because they are much less fat-soluble than the typical antipsychotics and because they are readily released from D2 receptor and brain tissue.<a href="#cite_note-pmid11873706-55">[55]</a> The typical antipsychotics remain attached to the D2 receptors and accumulate in the brain tissue which may lead to TD.<a href="#cite_note-pmid11873706-55">[55]</a> <div class="mw-heading mw-heading3"><h3 id="Cardiovascular_disease">Cardiovascular disease</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=11" title="Edit section: Cardiovascular disease">edit</a>]</div> It has been suggested that atypical antipsychotics increase the risk of cardiovascular disease.<a href="#cite_note-pmid15156241-56">[56]</a><a href="#cite_note-57">[57]</a> However, Kabinoff and colleagues (2003) suggest that the increase in cardiovascular disease is seen regardless of the treatment received, and that it is instead caused by many different factors such as lifestyle or diet.<a href="#cite_note-pmid15156241-56">[56]</a> Despite increasing some <a href="/wiki/Cardiovascular_disease#Risk_factors" title="Cardiovascular disease">risk factors</a>, SGAs are not associated with excess cardiovascular mortality when used to treat serious psychiatric disorders.<a href="#cite_note-58">[58]</a> <div class="mw-heading mw-heading3"><h3 id="Sexual_side_effects">Sexual side effects</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=12" title="Edit section: Sexual side effects">edit</a>]</div> Sexual side effects have also been reported when taking atypical antipsychotics.<a href="#cite_note-59">[59]</a> In males antipsychotics reduce sexual interest, impair sexual performance with the main difficulties being failure to ejaculate.<a href="#cite_note-McKim,_W._2007_pp.241-260-60">[60]</a> In females there may be abnormal menstrual cycles and infertility.<a href="#cite_note-McKim,_W._2007_pp.241-260-60">[60]</a> In both males and females the breasts may become enlarged and a fluid will sometimes ooze from the nipples.<a href="#cite_note-McKim,_W._2007_pp.241-260-60">[60]</a> Sexual adverse effects caused by some antipsychotics are a result of an increase of <a href="/wiki/Prolactin" title="Prolactin">prolactin</a>. Sulpiride and Amisulpiride, as well as Risperdone and paliperidone (to a lesser extent), cause a high increase of prolactin. <div class="mw-heading mw-heading3"><h3 id="Dementia">Dementia</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=13" title="Edit section: Dementia">edit</a>]</div> In April 2005, the US Food and Drug Administration (FDA) issued an advisory and subsequent black box warning regarding the risks of atypical antipsychotic use among elderly patients with dementia. The FDA advisory was associated with decreases in the use of atypical antipsychotics, especially among elderly patients with dementia.<a href="#cite_note-dorsey-61">[61]</a> Subsequent research reports confirmed the mortality risks associated with the use of both conventional and atypical antipsychotics to treat patients with dementia. Consequently, in 2008 the FDA issued although a black box warning for classical neuroleptics. Data on treatment efficacies are strongest for atypical antipsychotics. Adverse effects in patients with <a href="/wiki/Dementia" title="Dementia">dementia</a> include an increased risk of mortality and cerebrovascular events, as well as metabolic effects, extrapyramidal symptoms, falls, cognitive worsening, cardiac arrhythmia, and pneumonia.<a href="#cite_note-62">[62]</a> Conventional antipsychotics may pose an even greater safety risk. No clear efficacy evidence exists to support the use of alternative psychotropic classes (e.g. antidepressants, anticonvulsants) in patients with dementia.<a href="#cite_note-63">[63]</a> <div class="mw-heading mw-heading3"><h3 id="Drug-induced_OCD">Drug-induced OCD</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=14" title="Edit section: Drug-induced OCD">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Obsessive%E2%80%93compulsive_disorder#Drug-induced_OCD" title="Obsessive–compulsive disorder">Obsessive–compulsive disorder § Drug-induced OCD</a></div> Many different types of medication can induce in patients that have never had symptoms before. A new chapter about OCD in the <a href="/wiki/DSM-5" title="DSM-5">DSM-5</a> (2013) now specifically includes drug-induced OCD. There are reports that some atypical antipsychotics could cause drug-induced OCD in already schizophrenic patients.<a href="#cite_note-64">[64]</a><a href="#cite_note-65">[65]</a><a href="#cite_note-66">[66]</a><a href="#cite_note-67">[67]</a> <div class="mw-heading mw-heading3"><h3 id="Metabolism">Metabolism</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=15" title="Edit section: Metabolism">edit</a>]</div> Recently, metabolic side effects have been of considerable concern to clinicians, patients and the FDA. In 2003, the <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) required all manufacturers of atypical antipsychotics to change their labeling to include a warning about the risks of <a href="/wiki/Hyperglycemia" title="Hyperglycemia">hyperglycemia</a> and <a href="/wiki/Diabetes" title="Diabetes">diabetes</a> with atypical antipsychotics. It must also be pointed out that although all atypicals must carry the warning on their labeling, some evidence shows that atypicals are not equal in their effects on weight and <a href="/wiki/Insulin_sensitivity" class="mw-redirect" title="Insulin sensitivity">insulin sensitivity</a>.<a href="#cite_note-pmid14747245-68">[68]</a> The general consensus is that clozapine and olanzapine are associated with the greatest effects on weight gain and decreased insulin sensitivity, followed by risperidone and quetiapine.<a href="#cite_note-pmid14747245-68">[68]</a> Ziprasidone and aripiprazole are thought to have the smallest effects on weight and <a href="/wiki/Insulin_resistance" title="Insulin resistance">insulin resistance</a>, but clinical experience with these newer agents is not as developed as that with the older agents.<a href="#cite_note-pmid14747245-68">[68]</a> The mechanism of these adverse effects is not completely understood but it is believed to result from a complex interaction between a number of pharmacologic actions of these drugs. Their effects on weight are believed to mostly derive from their actions on the <a href="/wiki/Histamine_H1_receptor" title="Histamine H1 receptor">H1</a> and <a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">5-HT2C</a> receptors, while their effects on insulin sensitivity are believed to be the result of a combination of their effects on body weight (as increased body mass is known to be a risk factor for insulin resistance) and their antagonistic effects on the <a href="/wiki/Muscarinic_acetylcholine_receptor_M3" title="Muscarinic acetylcholine receptor M3">M3 receptor</a>. Some of the newer agents, however, such as risperidone and its metabolite paliperidone, ziprasidone, lurasidone, aripiprazole, asenapine and iloperidone, have clinically insignificant effects on the <a href="/wiki/Muscarinic_acetylcholine_receptor_M3" title="Muscarinic acetylcholine receptor M3">M3</a> receptor and appear to carry a lower risk of insulin resistance. Whereas clozapine, olanzapine and quetiapine (indirectly via its active metabolite, norquetiapine) all antagonise the M3 receptor at therapeutic-relevant concentrations.<a href="#cite_note-GG-69">[69]</a> Recent evidence suggests a role of the <a href="/wiki/Alpha-1_adrenergic_receptor" title="Alpha-1 adrenergic receptor">α1 adrenoceptor</a> and <a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT2A receptor</a> in the metabolic effects of atypical antipsychotics. The <a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT2A receptor</a>, however, is also believed to play a crucial role in the therapeutic advantages of atypical antipsychotics over their predecessors, the typical antipsychotics.<a href="#cite_note-70">[70]</a> The two atypical antipsychotics with trials showing that had a low incidence of weight gain in large meta-analysis were lurasidone and aripiprazole.<a href="#cite_note-71">[71]</a> In a meta-analysis of 18 antipsychotics, olanzapine and clozapine exhibited the worst metabolic parameters and aripiprazole, brexpiprazole, cariprazine, lurasidone, and ziprasidone the most benign parameters.<a href="#cite_note-72">[72]</a> <a href="/wiki/Aripiprazole" title="Aripiprazole">Aripiprazole</a>, <a href="/wiki/Asenapine" title="Asenapine">asenapine</a>, <a href="/wiki/Ziprasidone" title="Ziprasidone">ziprasidone</a> and <a href="/wiki/Lurasidone" title="Lurasidone">lurasidone</a> have low propensity to cause weight gain.<a href="#cite_note-73">[73]</a> Lumateperone was found to cause minimal weight gain in a long-term 12 month follow-up study.<a href="#cite_note-74">[74]</a> A study by Sernyak and colleagues found that the prevalence of diabetes in atypical antipsychotic treatments was statistically significantly higher than that of conventional treatment.<a href="#cite_note-pmid15156241-56">[56]</a> The authors of this study suggest that there is a causal relationship between atypical antipsychotics and diabetes, however Kabinoff et al. argue that the findings only suggest a temporal association.<a href="#cite_note-pmid15156241-56">[56]</a> Kabinoff et al. suggest that there is insufficient data from large studies to demonstrate a consistent or significant difference in the risk of insulin resistance during treatment with various atypical antipsychotics.<a href="#cite_note-pmid15156241-56">[56]</a> Prescribing <a href="/wiki/Topiramate" title="Topiramate">topiramate</a>, <a href="/wiki/Zonisamide" title="Zonisamide">zonisamide</a>, <a href="/wiki/Metformin" title="Metformin">metformin</a>, <a href="/wiki/GLP-1_receptor_agonist" title="GLP-1 receptor agonist">GLP-1 receptor agonists</a>, or <a href="/wiki/Nizatidine" title="Nizatidine">nizatidine</a> alongside an antipsychotic significantly reduces weight gain.<a href="#cite_note-75">[75]</a> <div class="mw-heading mw-heading3"><h3 id="Comparison_table_of_adverse_effects">Comparison table of adverse effects</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=16" title="Edit section: Comparison table of adverse effects">edit</a>]</div> <table class="wikitable collapsible collapsed" style="width:100%;"> <tbody><tr> <th colspan="15">Comparison of side effects for atypical antipsychotics </th></tr> <tr> <th>Generic Name</th> <th>Weight gain</th> <th><a href="/wiki/Metabolic_syndrome" title="Metabolic syndrome">Metabolic Effects</a></th> <th><a href="/wiki/Extrapyramidal_symptoms" title="Extrapyramidal symptoms">EPS</a></th> <th><a href="/wiki/Hyperprolactinaemia" title="Hyperprolactinaemia">High prolactin</a></th> <th>Sedation</th> <th><a href="/wiki/Hypotension" title="Hypotension">Hypotension</a> / <a href="/wiki/Orthostatic_hypotension" title="Orthostatic hypotension">Orthostasis</a></th> <th><a href="/wiki/QT_interval" title="QT interval">QTc</a> prolongation</th> <th><a href="/wiki/Anticholinergic" title="Anticholinergic">Anti-ACh</a> effects</th> <th>Other adverse effects </th></tr> <tr> <th><a href="/wiki/Amisulpride" title="Amisulpride">Amisulpride</a> </th> <td><style data-mw-deduplicate="TemplateStyles:r1239334494">@media screen{html.skin-theme-clientpref-night .mw-parser-output div:not(.notheme)>.tmp-color,html.skin-theme-clientpref-night .mw-parser-output p>.tmp-color,html.skin-theme-clientpref-night .mw-parser-output table:not(.notheme) .tmp-color{color:inherit!important}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output div:not(.notheme)>.tmp-color,html.skin-theme-clientpref-os .mw-parser-output p>.tmp-color,html.skin-theme-clientpref-os .mw-parser-output table:not(.notheme) .tmp-color{color:inherit!important}}</style>+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />++</td> <td>-</td> <td>-</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+++</td> <td>-</td> <td><a href="/wiki/Seizures" class="mw-redirect" title="Seizures">Seizures</a>, <a href="/wiki/Suicidal_ideation" title="Suicidal ideation">suicidal ideation</a> </td></tr> <tr> <th><a href="/wiki/Aripiprazole" title="Aripiprazole">Aripiprazole</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />10–20%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />-<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />10–20%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td>-</td> <td>-</td> <td>Seizures (0.1–0.3%), <a href="/wiki/Anxiety" title="Anxiety">anxiety</a>, <a href="/wiki/Rhabdomyolysis" title="Rhabdomyolysis">rhabdomyolysis</a>, <a href="/wiki/Pancreatitis" title="Pancreatitis">pancreatitis</a> (<0.1%), <a href="/wiki/Agranulocytosis" title="Agranulocytosis">agranulocytosis</a> (<1%), <a href="/wiki/Leukopenia" title="Leukopenia">leukopenia</a>, <a href="/wiki/Neutropenia" title="Neutropenia">neutropenia</a>, suicidal ideation, <a href="/wiki/Angioedema" title="Angioedema">angioedema</a> (0.1–1%) </td></tr> <tr> <th><a href="/wiki/Asenapine" title="Asenapine">Asenapine</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />20%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />10–20%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td>-</td> <td><a href="/wiki/Hypersensitivity_reaction" class="mw-redirect" title="Hypersensitivity reaction">Immune hypersensitivity reaction</a>, angioedema, suicidal ideation </td></tr> <tr> <th><a href="/wiki/Blonanserin" title="Blonanserin">Blonanserin</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+/-</td> <td>-</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />++</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+/-</td> <td>-</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+/-</td> <td> </td></tr> <tr> <th><a href="/wiki/Clozapine" title="Clozapine">Clozapine</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />20–30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–15%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />-<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />-<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />>30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />20–30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+++</td> <td>Seizures (3–5%), agranulocytosis (1.3%), leukopenia, <a href="/wiki/Pneumonia_severity_index" title="Pneumonia severity index">pneumonia</a>, <a href="/wiki/Respiratory_arrest" title="Respiratory arrest">respiratory arrest</a>, <a href="/wiki/Angle_closure_glaucoma" class="mw-redirect" title="Angle closure glaucoma">angle-closure glaucoma</a>, <a href="/wiki/Eosinophilia" title="Eosinophilia">eosinophilia</a> (1%), <a href="/wiki/Thrombocytopenia" title="Thrombocytopenia">thrombocytopenia</a>, <a href="/wiki/Stevens%E2%80%93Johnson_syndrome" title="Stevens–Johnson syndrome">Stevens–Johnson syndrome</a>, <a href="/wiki/Myocarditis" title="Myocarditis">myocarditis</a>, <a href="/wiki/Erythema_multiforme" title="Erythema multiforme">erythema multiforme</a> and abnormal peristalsis </td></tr> <tr> <th><a href="/wiki/Iloperidone" title="Iloperidone">Iloperidone</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td>-<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />10–20%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />++</td> <td>-</td> <td>Suicidal ideation (0.4–1.1%), <a href="/wiki/Syncope_(medicine)" title="Syncope (medicine)">syncope</a> (0.4%) </td></tr> <tr> <th><a href="/wiki/Lurasidone" title="Lurasidone">Lurasidone</a> </th> <td>-<a href="#cite_note-wolters-76">[76]</a></td> <td>-<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />>30%<a href="#cite_note-wolters-76">[76]</a></td> <td>-<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />20–30%<a href="#cite_note-wolters-76">[76]</a></td> <td>-<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td>Agranulocytosis, seizures (<1%), elevated serum <a href="/wiki/Creatinine" title="Creatinine">creatinine</a> (2–4%) </td></tr> <tr> <th><a href="/wiki/Melperone" title="Melperone">Melperone</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+/-</td> <td>-</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+/<link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />++</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+/<link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />++</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />++</td> <td>-</td> <td><a href="/wiki/Agranulocytosis" title="Agranulocytosis">Agranulocytosis</a>, <a href="/wiki/Neutropenia" title="Neutropenia">neutropenia</a> and <a href="/wiki/Leukopenia" title="Leukopenia">leukopenia</a> </td></tr> <tr> <th><a href="/wiki/Olanzapine" title="Olanzapine">Olanzapine</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />20–30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–15%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />20-30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />20–30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />>30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><a href="/wiki/Pancreatitis" title="Pancreatitis">Acute haemorrhagic pancreatitis</a>, immune hypersensitivity reaction, seizures (0.9%), <a href="/wiki/Status_epilepticus" title="Status epilepticus">status epilepticus</a>, suicidal ideation (0.1–1%) </td></tr> <tr> <th><a href="/wiki/Paliperidone" title="Paliperidone">Paliperidone</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td>-<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />10–20%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />>30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />20–30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+/- (7%)</td> <td>-</td> <td>Agranulocytosis, leukopenia, <a href="/wiki/Priapism" title="Priapism">priapism</a>, <a href="/wiki/Dysphagia" title="Dysphagia">dysphagia</a>, <a href="/wiki/Hyperprolactinaemia" title="Hyperprolactinaemia">hyperprolactinaemia</a>, <a href="/wiki/Sexual_dysfunction" title="Sexual dysfunction">sexual dysfunction</a><a href="#cite_note-Prolactin_SD-77">[77]</a> </td></tr> <tr> <th><a href="/wiki/Perospirone" title="Perospirone">Perospirone</a> </th> <td>?</td> <td>?</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />>30%<a href="#cite_note-onrust-78">[78]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td>?</td> <td>-</td> <td>Insomnia in up to 23%,<a href="#cite_note-onrust-78">[78]</a> <a href="/wiki/Creatine_phosphokinase" class="mw-redirect" title="Creatine phosphokinase">CPK</a> elevation<a href="#cite_note-onrust-78">[78]</a> <a href="/wiki/Neuroleptic_malignant_syndrome" title="Neuroleptic malignant syndrome">neuroleptic malignant syndrome</a><a href="#cite_note-onrust-78">[78]</a> </td></tr> <tr> <th><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />20–30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–15%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />10–20%<a href="#cite_note-wolters-76">[76]</a></td> <td>-<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />>30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />++</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td>Agranulocytosis, leukopenia, neutropenia (0.3%), anaphylaxis, seizures (0.05–0.5%), <a href="/wiki/Priapism" title="Priapism">priapism</a>, <a href="/wiki/Tardive_dyskinesia" title="Tardive dyskinesia">tardive dyskinesia</a> (0.1–5%), suicidal ideation, pancreatitis, syncope (0.3–1%) </td></tr> <tr> <th><a href="/wiki/Remoxipride" title="Remoxipride">Remoxipride</a><a href="#cite_note-79">[79]</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+/-</td> <td>-</td> <td>-</td> <td>-<a href="#cite_note-pmid11873706-55">[55]</a></td> <td>-</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+/-</td> <td>?</td> <td>-</td> <td>There is a risk of <a href="/wiki/Aplastic_anaemia" class="mw-redirect" title="Aplastic anaemia">aplastic anaemia</a> risk which is what led to its removal from the market. </td></tr> <tr> <th><a href="/wiki/Risperidone" title="Risperidone">Risperidone</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />10–20%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />20–30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />>30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />>30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td>-</td> <td>Syncope (1%), pancreatitis, hypothermia, agranulocytosis, leukopenia, neutropenia, thrombocytopenia, <a href="/wiki/Hyperprolactinaemia" title="Hyperprolactinaemia">hyperprolactinaemia</a>, <a href="/wiki/Sexual_dysfunction" title="Sexual dysfunction">sexual dysfunction</a>,<a href="#cite_note-Prolactin_SD-77">[77]</a> <a href="/wiki/Thrombotic_thrombocytopenic_purpura" title="Thrombotic thrombocytopenic purpura">thrombotic thrombocytopenic purpura</a>, <a href="/wiki/Cerebrovascular_incident" class="mw-redirect" title="Cerebrovascular incident">cerebrovascular incident</a> (<5%), tardive dyskinesia (<5%), priapism, neuroleptic malignant syndrome (<1%), <a href="/wiki/Gynecomastia" title="Gynecomastia">gynecomastia</a>, galactorrhea<a href="#cite_note-80">[80]</a> </td></tr> <tr> <th><a href="/wiki/Sertindole" title="Sertindole">Sertindole</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />++</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+/-</td> <td>-</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />++</td> <td>-</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+++</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+++</td> <td>-</td> <td>- </td></tr> <tr> <th><a href="/wiki/Sulpiride" title="Sulpiride">Sulpiride</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+++</td> <td>-</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+++</td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />+</td> <td>-</td> <td>Jaundice </td></tr> <tr> <th><a href="/wiki/Ziprasidone" title="Ziprasidone">Ziprasidone</a> </th> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td>-<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />20–30%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />0–10%<a href="#cite_note-wolters-76">[76]</a></td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239334494" />++</td> <td>-</td> <td>Syncope (0.6%), dysphagia (0.1–2%), bone marrow suppression, seizure (0.4%), priapism </td></tr></tbody></table> <div class="mw-heading mw-heading3"><h3 id="Discontinuation">Discontinuation</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=17" title="Edit section: Discontinuation">edit</a>]</div> The <a href="/wiki/British_National_Formulary" title="British National Formulary">British National Formulary</a> recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse.<a href="#cite_note-Group_2009_192-81">[81]</a> Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite.<a href="#cite_note-Had2004-82">[82]</a> Other symptoms may include restlessness, increased sweating, and trouble sleeping.<a href="#cite_note-Had2004-82">[82]</a> Less commonly there may be a feeling of the world spinning, numbness, or muscle pains.<a href="#cite_note-Had2004-82">[82]</a> Symptoms generally resolve after a short period of time.<a href="#cite_note-Had2004-82">[82]</a> There is tentative evidence that discontinuation of antipsychotics can result in psychosis.<a href="#cite_note-83">[83]</a> It may also result in reoccurrence of the condition that is being treated.<a href="#cite_note-84">[84]</a> Rarely tardive dyskinesia can occur when the medication is stopped.<a href="#cite_note-Had2004-82">[82]</a> <div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=18" title="Edit section: Pharmacology">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Pharmacodynamics">Pharmacodynamics</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=19" title="Edit section: Pharmacodynamics">edit</a>]</div> The atypical antipsychotics integrate with the <a href="/wiki/Serotonin" title="Serotonin">serotonin</a> (5-HT), <a href="/wiki/Norepinephrine" title="Norepinephrine">norepinephrine</a> (α, β), and <a href="/wiki/Dopamine" title="Dopamine">dopamine</a> (DA) receptors in order to effectively treat schizophrenia.<a href="#cite_note-85">[85]</a> <a href="/wiki/Dopamine_receptor_D2" title="Dopamine receptor D2">D2 Receptor</a>: Hyperactive dopaminergic activity on <a href="/wiki/Dopamine_receptor_D2" title="Dopamine receptor D2">D2 receptors</a> in the mesolimbic pathway is responsible for the positive symptoms of schizophrenia (hallucinations, delusions, paranoia). After taking an antipsychotic, <a href="/wiki/Receptor_antagonist" title="Receptor antagonist">antagonism</a> of D2 receptors occurs throughout the entire brain, leading to a number of deleterious side effects from D2 receptor antagonism throughout the entire <a href="/wiki/Dopaminergic_pathways" title="Dopaminergic pathways">dopamine pathway</a> system. It's not possible to affect D2 receptors only in the <a href="/wiki/Mesolimbic_pathway" title="Mesolimbic pathway">mesolimbic pathway</a>,<a href="#cite_note-Stahl_AP_Explained_1-86">[86]</a><a href="#cite_note-S1-87">[Stahl AP Explained 1 - 1]</a> but <a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT2A receptor</a> antagonism reverses these side effects to some extent.<a href="#cite_note-S2-88">[Stahl AP Explained 1 - 2]</a> Reducing D2 dopaminergic activity in the mesolimbic pathway also results in an <a href="/wiki/Anhedonia" title="Anhedonia">anhedonic</a> effect, reducing pleasure and motivation. In the mesocortical pathway to the <a href="/wiki/DLPFC" class="mw-redirect" title="DLPFC">DLPFC</a> and <a href="/wiki/VMPFC" class="mw-redirect" title="VMPFC">VMPFC</a>, endogenous D2 receptor dopamine activity is sometimes low in schizophrenia, resulting in cognitive, affective, and, broadly, the negative symptoms of schizophrenia. D2 receptor antagonism further compounds these problems. In the <a href="/wiki/Nigrostriatal_pathway" title="Nigrostriatal pathway">nigrostriatal pathway</a>, D2 receptor antagonism results in <a href="/wiki/Extrapyramidal_symptoms" title="Extrapyramidal symptoms">extrapyramidal symptoms</a>. If this antagonism occurs long enough, symptoms of EPS may become permanent, even if antipsychotic use is discontinued. In the <a href="/wiki/Tuberoinfundibular_pathway" title="Tuberoinfundibular pathway">tuberoinfundibular pathway</a>, D2 receptor antagonism results in elevated <a href="/wiki/Prolactin" title="Prolactin">prolactin</a>. If prolactin levels become high enough, <a href="/wiki/Hyperprolactinaemia" title="Hyperprolactinaemia">hyperprolactinaemia</a> may occur, resulting in sexual dysfunction, weight gain, more rapid demineralization of bones, and possibly <a href="/wiki/Galactorrhea" title="Galactorrhea">galactorrhea</a> and <a href="/wiki/Amenorrhea" title="Amenorrhea">amenorrhea</a>.<a href="#cite_note-S1-87">[Stahl AP Explained 1 - 1]</a> <a href="/wiki/5-HT2A" class="mw-redirect" title="5-HT2A">5-HT2A Receptor</a>: When <a href="/wiki/Serotonin" title="Serotonin">serotonin</a> is released on to <a href="/wiki/Chemical_synapse#Signaling_in_chemical_synapses" title="Chemical synapse">postsynaptic</a> 5-HT2A receptors, the dopamine neuron is inhibited, thus acting as a brake on dopamine release.<a href="#cite_note-S2-88">[Stahl AP Explained 1 - 2]</a> This brake is disrupted through action of a 5-HT2A antagonist, which disinhibits the dopamine neuron, stimulating dopamine release. The result of this is that dopamine competes with antipsychotic D2 antagonistic action at D2 receptors, thereby reducing antagonistic binding there and eliminating or lowering D2 antagonistic effects in several pathways of the dopamine system.<a href="#cite_note-S2-88">[Stahl AP Explained 1 - 2]</a> In the nigrostratial pathway, it reduces EPS. In the tuberoinfundibular pathway, it reduces or eliminates prolactin elevation.<a href="#cite_note-S3-89">[Stahl AP Explained 1 - 3]</a> Dopamine release in the mesolimbic pathway from 5-HT2A antagonism does not appear to be as robust as in the other pathways of the dopamine system, thereby accounting for why atypical antipsychotics still retain part of their efficacy against the positive symptoms of schizophrenia through their D2 antagonism.<a href="#cite_note-S3-89">[Stahl AP Explained 1 - 3]</a> When 5-HT2A antagonistic agent particles occupy 5-HT2A receptors in the mesocortical pathway and in the prefrontal cortex, the negative symptoms of schizophrenia, affective symptoms, and cognitive deficits and abnormalities are treated and reduced.<a href="#cite_note-S3-89">[Stahl AP Explained 1 - 3]</a> Furthermore, 5-HT2A receptor antagonism blocks the serotonergic excitation of cortical pyramidal cells, reducing <a href="/wiki/Glutamic_acid" title="Glutamic acid">glutamate</a> release, which in turn lowers hyperactive dopaminergic D2 receptor activity in the mesolimbic pathway, reducing or eliminating the positive symptoms of schizophrenia.<a href="#cite_note-S3-89">[Stahl AP Explained 1 - 3]</a><a href="#cite_note-90">[87]</a><a href="#cite_note-91">[88]</a> <a href="/wiki/Brexpiprazole" title="Brexpiprazole">Brexpiprazole</a>, approved by the US FDA in 2015, has a similar binding profile to <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a> as a partial D2 <a href="/wiki/Agonist" title="Agonist">agonist</a> with moderate <a href="/wiki/Histamine" title="Histamine">histamine</a> binding, but with brexipiprazole has a higher affinity for serotonin receptor <a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT2A</a>. Some effects of <a href="/wiki/5-HT1A" class="mw-redirect" title="5-HT1A">5-HT1A</a> receptor activation include decreased aggressive behavior/ideation,<a href="#cite_note-pmid16310183-92">[89]</a> increased sociability, and decreased anxiety and depression.[<a href="/wiki/Wikipedia:No_original_research#Primary,_secondary_and_tertiary_sources" title="Wikipedia:No original research">non-primary source needed</a>] Blockade of the 5-HT2C receptor increases <a href="/wiki/Serotonin" title="Serotonin">serotonin</a>, releasing norepinephrine and dopamine within the brain.<a href="#cite_note-Stahl_AP_Explained_1-86">[86]</a> But neuronal <a href="/wiki/Reuptake" title="Reuptake">reuptake</a> of norepinephrine is <a href="/wiki/Reuptake_inhibitor" title="Reuptake inhibitor">limited sharply</a> by some antipsychotics, e.g. <a href="/wiki/Ziprasidone" title="Ziprasidone">ziprasidone</a>. Increased norepinephrine can cause increased glucose(blood sugar) levels.<a href="#cite_note-93">[90]</a><a href="#cite_note-94">[91]</a><a href="#cite_note-95">[92]</a> Increased blood sugar levels by increased norepinephrine causes hunger in many humans, which is why weight gain occurs with some antipsychotics if the norepinephrine is not inhibited.<a href="#cite_note-96">[93]</a><a href="#cite_note-97">[94]</a><a href="#cite_note-98">[95]</a><a href="#cite_note-99">[96]</a><a href="#cite_note-100">[97]</a> Inhibition of norepinephrine stabilizes mood in humans.<a href="#cite_note-101">[98]</a> <a href="/wiki/5-HT6" class="mw-redirect" title="5-HT6">5-HT6</a> receptor antagonists improve cognition, learning, and memory.<a href="#cite_note-pmid19086256-102">[99]</a> The <a href="/wiki/5-HT7" class="mw-redirect" title="5-HT7">5-HT7</a> receptor is very potent for the mitigation of bipolar conditions and also yields an antidepressant effect. The antipsychotics <a href="/wiki/Asenapine" title="Asenapine">asenapine</a>,<a href="#cite_note-pmid18308814-103">[100]</a> <a href="/wiki/Lurasidone" title="Lurasidone">lurasidone</a>,<a href="#cite_note-autogenerated1-104">[101]</a><a href="#cite_note-105">[102]</a> <a href="/wiki/Risperidone" title="Risperidone">risperidone</a>,<a href="#cite_note-106">[103]</a> and <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a><a href="#cite_note-107">[104]</a> are very potent at the 5-HT7 receptor. <a href="/wiki/Receptor_antagonist#Affinity" title="Receptor antagonist">Antagonistic affinity</a> for the <a href="/wiki/Histamine_H1_receptor" title="Histamine H1 receptor">H1</a> receptor also has an antidepressant effect. H1 antagonism blocks serotonin and norepinephrine reuptake. Patients with increased histamine levels have been observed to have lower serotonin levels.<a href="#cite_note-108">[105]</a> However, the H1 receptor is linked to weight gain. To have partial agonism at the <a href="/wiki/5-HT1A" class="mw-redirect" title="5-HT1A">5-HT1A</a> receptor can yield absence of weight gain in an antipsychotic. This is very relevant for ziprasidone,<a href="#cite_note-109">[106]</a><a href="#cite_note-110">[107]</a> but it creates a risk for a prolonged QTc interval.<a href="#cite_note-111">[108]</a><a href="#cite_note-112">[109]</a> On the other hand, blockade of the <a href="/wiki/5-HT3" class="mw-redirect" title="5-HT3">5-HT3</a> receptor removes the risk for a prolonged QTc interval,<a href="#cite_note-autogenerated1-104">[101]</a> but then creates a larger risk for weight gain. Relation to the 5-HT3 receptor increases caloric uptake and glucose,<a href="#cite_note-113">[110]</a> which is seen in clozapine and olanzapine.<a href="#cite_note-114">[111]</a><a href="#cite_note-115">[112]</a> Other ways for dopamine to resolve is to have agonism at both the D2 receptor and 5-HT1A receptor, which normalizes the dopamine level in the brain. This occurs with <a href="/wiki/Cariprazine" title="Cariprazine">cariprazine</a> and <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a>. Whether the anhedonic, loss of pleasure and motivation effect resulting from dopamine insufficiency or blockade at D2 receptors in the mesolimbic pathway, which is mediated in some part by antipsychotics (and despite dopamine release in the mesocortical pathway from 5-HT2A antagonism, which is seen in atypical antipsychotics), or the positive mood, mood stabilization, and cognitive improvement effect resulting from atypical antipsychotic serotonergic activity is greater for the overall quality of life effect of an atypical antipsychotic is a question that is variable between individual experience and the atypical antipsychotic(s) being used.<a href="#cite_note-Stahl_AP_Explained_1-86">[86]</a> <div class="mw-heading mw-heading4"><h4 id="Terms">Terms</h4>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=20" title="Edit section: Terms">edit</a>]</div> <a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Inhibition.</a> Disinhibition: The opposite process of inhibition, the turning on of a biological function. <a href="/wiki/Exocytosis" title="Exocytosis">Release</a>: Causes the appropriate neurotransmitters to be discharged in vesicles into the synapse where they attempt to bind to and activate a receptor. <a href="/wiki/Downregulation_and_upregulation" title="Downregulation and upregulation">Downregulation and Upregulation</a>.[<a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed">citation needed</a>] <div class="mw-heading mw-heading3"><h3 id="Binding_profile">Binding profile</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=21" title="Edit section: Binding profile">edit</a>]</div> Note: Unless otherwise specified, the drugs below serve as antagonists/inverse agonists at the receptors listed. <table class="wikitable sortable"> <tbody><tr> <th>Generic Name<a href="#cite_note-116">[113]</a></th> <th><a href="/wiki/Dopamine_receptor_D1" title="Dopamine receptor D1">D1</a></th> <th><a href="/wiki/Dopamine_receptor_D2" title="Dopamine receptor D2">D2</a></th> <th><a href="/wiki/Dopamine_receptor_D3" title="Dopamine receptor D3">D3</a></th> <th><a href="/wiki/Dopamine_receptor_D4" title="Dopamine receptor D4">D4</a></th> <th><a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">5-HT1A</a></th> <th><a href="/wiki/5-HT1B_receptor" title="5-HT1B receptor">5-HT1B</a></th> <th><a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT2A</a></th> <th><a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">5-HT2C</a></th> <th><a href="/wiki/5-HT6_receptor" title="5-HT6 receptor">5-HT6</a></th> <th><a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">5-HT7</a> </th> <th><a href="/wiki/Alpha-1A_adrenergic_receptor" title="Alpha-1A adrenergic receptor">α1A</a></th> <th><a href="/wiki/Alpha-1_adrenergic_receptor" title="Alpha-1 adrenergic receptor">α1</a></th> <th><a href="/wiki/Alpha-2_adrenergic_receptor" title="Alpha-2 adrenergic receptor">α2</a></th> <th><a href="/wiki/Muscarinic_acetylcholine_receptor_M1" title="Muscarinic acetylcholine receptor M1">M1</a></th> <th><a href="/wiki/Muscarinic_acetylcholine_receptor_M3" title="Muscarinic acetylcholine receptor M3">M3</a></th> <th><a href="/wiki/Histamine_H1_receptor" title="Histamine H1 receptor">H1</a> </th></tr> <tr> <td><a href="/wiki/Amisulpride" title="Amisulpride">Amisulpride</a></td> <td>-</td> <td>++++</td> <td>++++</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>++/+ </td> <td></td> <td>-</td> <td>+/-</td> <td>-</td> <td>-</td> <td>- </td></tr> <tr> <td><a href="/wiki/Aripiprazole" title="Aripiprazole">Aripiprazole</a></td> <td>+</td> <td>++++ (PA)</td> <td>+++ (PA)</td> <td>+ (PA)</td> <td>+++ (PA)</td> <td>+</td> <td>+++</td> <td>++ (PA)</td> <td>+</td> <td>+++ (PA) </td> <td></td> <td>++/+</td> <td>+</td> <td>-</td> <td>-</td> <td>++/+ </td></tr> <tr> <td><a href="/wiki/Asenapine" title="Asenapine">Asenapine</a></td> <td>+++</td> <td>+++</td> <td>++++</td> <td>+++</td> <td>+++ (PA)</td> <td>+++</td> <td>++++</td> <td>++++</td> <td>++++</td> <td>++++ </td> <td></td> <td>+++</td> <td>+++</td> <td>-</td> <td>-</td> <td>+++ </td></tr> <tr> <td><a href="/wiki/Blonanserin" title="Blonanserin">Blonanserin</a></td> <td>-</td> <td>++++</td> <td>++++</td> <td>+</td> <td>-</td> <td>?</td> <td>+++</td> <td>+</td> <td>+</td> <td>+/- </td> <td></td> <td>+ (RC)</td> <td>+ (RC)</td> <td>+</td> <td>?</td> <td>- </td></tr> <tr> <td><a href="/wiki/Brexpiprazole" title="Brexpiprazole">Brexpiprazole</a></td> <td>++</td> <td>+++++ (PA)</td> <td>++++ (PA)</td> <td>++++</td> <td>+++++ (PA)</td> <td>+++</td> <td>+++++</td> <td>+++ (PA)</td> <td>+++</td> <td>++++ </td> <td>++</td> <td></td> <td></td> <td></td> <td>-</td> <td>+++ </td></tr> <tr> <td><a href="/wiki/Cariprazine" title="Cariprazine">Cariprazine</a></td> <td></td> <td>++++ (PA)</td> <td>+++++ (PA)</td> <td></td> <td>++++ (PA)</td> <td></td> <td>+++</td> <td>++</td> <td></td> <td>++ </td> <td></td> <td>++</td> <td></td> <td>-</td> <td>-</td> <td>+++ </td></tr> <tr> <td><a href="/wiki/Clozapine" title="Clozapine">Clozapine</a></td> <td>++</td> <td>++</td> <td>++</td> <td>+++</td> <td>++ (PA)</td> <td>++/+</td> <td>++++</td> <td>++++</td> <td>+++</td> <td>+++ </td> <td></td> <td>++++</td> <td>+++</td> <td>++++</td> <td>+++</td> <td>++++ </td></tr> <tr> <td><a href="/wiki/Iloperidone" title="Iloperidone">Iloperidone</a></td> <td>+</td> <td>+++</td> <td>+++</td> <td>++</td> <td>+ (PA)</td> <td>+</td> <td>+++</td> <td>+</td> <td>++</td> <td>+ </td> <td></td> <td>++++</td> <td>+++/++</td> <td>-</td> <td>-</td> <td>+++ </td></tr> <tr> <td><a href="/wiki/Lurasidone" title="Lurasidone">Lurasidone</a></td> <td>+</td> <td>++++</td> <td>++</td> <td>++</td> <td>+++ (PA)</td> <td>?</td> <td>++++</td> <td>+/-</td> <td>?</td> <td>++++ </td> <td></td> <td>-</td> <td>+++/++</td> <td>-</td> <td>-</td> <td>- </td></tr> <tr> <td><a href="/wiki/Melperone" title="Melperone">Melperone</a></td> <td>?</td> <td>++</td> <td>++++</td> <td>++</td> <td>+ (PA)</td> <td>?</td> <td>++</td> <td>+</td> <td>-</td> <td>++ </td> <td></td> <td>++</td> <td>++</td> <td>-</td> <td>-</td> <td>++ </td></tr> <tr> <td><a href="/wiki/Olanzapine" title="Olanzapine">Olanzapine</a></td> <td>+++</td> <td>+++</td> <td>+++</td> <td>+++</td> <td>+ (PA)</td> <td>++</td> <td>++++</td> <td>+++</td> <td>+++</td> <td>++ </td> <td></td> <td>++</td> <td>++</td> <td>++++</td> <td>++++</td> <td>++++ </td></tr> <tr> <td><a href="/wiki/Paliperidone" title="Paliperidone">Paliperidone</a></td> <td>++</td> <td>+++</td> <td>+++</td> <td>++</td> <td>+ (PA)</td> <td>+++/++</td> <td>++++</td> <td>+</td> <td>-</td> <td>++++/+++ </td> <td></td> <td>+++</td> <td>+++</td> <td>-</td> <td>-</td> <td>+++/++ </td></tr> <tr> <td><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a></td> <td>+</td> <td>++/+</td> <td>++/+</td> <td>+</td> <td>++/+ (PA)</td> <td>+</td> <td>+</td> <td>+</td> <td>++</td> <td>+++/++ </td> <td></td> <td>++++</td> <td>+++/++</td> <td>++</td> <td>+++</td> <td>++++ </td></tr> <tr> <td><a href="/wiki/Risperidone" title="Risperidone">Risperidone</a></td> <td>++</td> <td>+++</td> <td>++</td> <td>+++</td> <td>+ (PA)</td> <td>++</td> <td>++++</td> <td>++</td> <td>-</td> <td>+++/++ </td> <td>++</td> <td>+++/++</td> <td>++</td> <td>-</td> <td>-</td> <td>++ </td></tr> <tr> <td><a href="/wiki/Sertindole" title="Sertindole">Sertindole</a></td> <td>?</td> <td>+++</td> <td>+++</td> <td>+++</td> <td>++/+ (PA)</td> <td>++</td> <td>++++</td> <td>++++</td> <td>+++</td> <td>++ </td> <td></td> <td>++++/+++</td> <td>+</td> <td>-</td> <td>-</td> <td>++/+ </td></tr> <tr> <td><a href="/wiki/Sulpiride" title="Sulpiride">Sulpiride</a></td> <td>?</td> <td>++++</td> <td>++++</td> <td>+++</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>- </td> <td></td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>- </td></tr> <tr> <td><a href="/wiki/Ziprasidone" title="Ziprasidone">Ziprasidone</a></td> <td>+++/++</td> <td>+++</td> <td>+++</td> <td>+++/++</td> <td>+++ (PA)</td> <td>+++ (PA)</td> <td>++++</td> <td>+++(PA)</td> <td>++</td> <td>+++ </td> <td></td> <td>+++/++</td> <td>++</td> <td>-</td> <td>-</td> <td>++ </td></tr> <tr> <td><a href="/wiki/Zotepine" title="Zotepine">Zotepine</a></td> <td>+++/++</td> <td>+++</td> <td>++++/+++</td> <td>+++</td> <td>++ (PA)</td> <td>+++</td> <td>++++</td> <td>++++ (RC)</td> <td>++++</td> <td>++++/+++ </td> <td></td> <td>+++</td> <td>+++/++</td> <td>++ (RC)</td> <td>++ (RC)</td> <td>++++ </td></tr></tbody></table> Legend: <table style="width: 350px"> <tbody><tr> <td></td> <td>No Affinity or No Data </td></tr> <tr> <td>-</td> <td>Clinically Insignificant </td></tr> <tr> <td>+</td> <td>Low </td></tr> <tr> <td>++</td> <td>Moderate </td></tr> <tr> <td>+++</td> <td>High </td></tr> <tr> <td>++++</td> <td>Very High </td></tr> <tr> <td>+++++</td> <td>Exceptionally High </td></tr> <tr> <td>PA</td> <td>Partial Agonist </td></tr> <tr> <td>RC</td> <td>Cloned Rat Receptor </td></tr></tbody></table> <div class="mw-heading mw-heading3"><h3 id="Pharmacokinetics">Pharmacokinetics</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=22" title="Edit section: Pharmacokinetics">edit</a>]</div> Atypical antipsychotics are most commonly administered orally.<a href="#cite_note-McKim,_W._2007_pp.241-260-60">[60]</a> Antipsychotics can also be injected, but this method is not as common.<a href="#cite_note-McKim,_W._2007_pp.241-260-60">[60]</a> They are lipid-soluble, are readily absorbed from the digestive tract, and can easily pass the blood–brain barrier and placental barriers.<a href="#cite_note-McKim,_W._2007_pp.241-260-60">[60]</a> Once in the brain, the antipsychotics work at the synapse by binding to the receptor.<a href="#cite_note-117">[114]</a> Antipsychotics are completely metabolized in the body and the metabolites are excreted in urine.<a href="#cite_note-McKim,_W._2007_pp.241-260-60">[60]</a> These drugs have relatively long half-lives.<a href="#cite_note-McKim,_W._2007_pp.241-260-60">[60]</a> Each drug has a different half-life, but the occupancy of the D2 receptor falls off within 24 hours with atypical antipsychotics, while lasting over 24 hours for the typical antipsychotics.<a href="#cite_note-pmid11873706-55">[55]</a> This may explain why relapse into psychosis happens quicker with atypical antipsychotics than with typical antipsychotics, as the drug is excreted faster and is no longer working in the brain.<a href="#cite_note-pmid11873706-55">[55]</a> Physical dependence with these drugs is very rare.<a href="#cite_note-McKim,_W._2007_pp.241-260-60">[60]</a> However, if the drug is abruptly discontinued, psychotic symptoms, movement disorders, and sleep difficulty may be observed.<a href="#cite_note-McKim,_W._2007_pp.241-260-60">[60]</a> It is possible that withdrawal is rarely seen because the AAP are stored in body fat tissues and slowly released.<a href="#cite_note-McKim,_W._2007_pp.241-260-60">[60]</a> <table class="wikitable collapsible collapsed" style="width:100%; font-size:88%"> <tbody><tr> <th colspan="10">Pharmacokinetic parameters of available atypical antipsychotics<a href="#cite_note-118">[115]</a><a href="#cite_note-119">[116]</a><a href="#cite_note-120">[117]</a> </th></tr> <tr> <th>Drug</th> <th>Route(s) of Administration<a href="#cite_note-121">[Note 1]</a></th> <th>Half-life (t1/2 in hours)</th> <th>Volume of distribution (Vd in L/kg)</th> <th>Protein binding</th> <th>Excretion</th> <th>Enzymes involved in metabolism</th> <th>Bioavailability</th> <th>Peak plasma time (h)</th> <th>Cmax (ng/mL) </th></tr> <tr> <td><a href="/wiki/Amisulpride" title="Amisulpride">Amisulpride</a></td> <td>Oral</td> <td>12</td> <td>5.8</td> <td>16%</td> <td>Urine (50%), faeces (20%; 70% of this is as unchanged drug)<a href="#cite_note-122">[Note 2]</a></td> <td>?</td> <td>48%</td> <td>Two peaks: 1 hr & 3-4 hrs post-oral dosing</td> <td>39±3 (1 hr), 54±4 (3-4 hrs) </td></tr> <tr> <td><a href="/wiki/Aripiprazole" title="Aripiprazole">Aripiprazole</a></td> <td>Oral, intramuscular (including depot)</td> <td>75 (94 for active metabolite)</td> <td>4.9</td> <td>99%</td> <td>Faeces (55%), urine (25%)</td> <td><a href="/wiki/CYP2D6" title="CYP2D6">CYP2D6</a> & <a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a></td> <td>87% (Oral), 100% (<a href="/wiki/Intramuscular" class="mw-redirect" title="Intramuscular">IM</a>)</td> <td>3-5</td> <td>? </td></tr> <tr> <td><a href="/wiki/Asenapine" title="Asenapine">Asenapine</a></td> <td>Sublingual</td> <td>24</td> <td>20-25</td> <td>95%</td> <td>Urine (50%), faeces (40%)</td> <td><a href="/wiki/CYP1A2" title="CYP1A2">CYP1A2</a> & <a href="/wiki/UGT1A4" title="UGT1A4">UGT1A4</a></td> <td>35% (sublingual), <2% (Oral)</td> <td>0.5-1.5</td> <td>4 </td></tr> <tr> <td><a href="/wiki/Blonanserin" title="Blonanserin">Blonanserin</a><a href="#cite_note-CNS_Drugs-123">[118]</a></td> <td>Oral</td> <td>10.7 (single 4 mg dose), 12 (single 8 mg dose), 16.2 (single 12 mg dose), 67.9 (repeated bid dosing)</td> <td>?</td> <td>>99.7%</td> <td>Urine (59%), faeces (30%)</td> <td><a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a></td> <td>84% (Oral)</td> <td><2</td> <td>0.14 (single 4 mg dose), 0.45 (single 8 mg dose), 0.76 (single 12 mg dose), 0.57 (bid dosing) </td></tr> <tr> <td><a href="/wiki/Clozapine" title="Clozapine">Clozapine</a></td> <td>Oral</td> <td>8 hours (single dosing), 12 (twice daily dosing)</td> <td>4.67</td> <td>97%</td> <td>Urine (50%), faeces (30%)</td> <td><a href="/wiki/CYP1A2" title="CYP1A2">CYP1A2</a>, <a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a>, <a href="/wiki/CYP2D6" title="CYP2D6">CYP2D6</a></td> <td>50-60%</td> <td>1.5-2.5</td> <td>102–771 </td></tr> <tr> <td><a href="/wiki/Iloperidone" title="Iloperidone">Iloperidone</a></td> <td>Oral</td> <td>?</td> <td>1340-2800</td> <td>95%</td> <td>Urine (45-58%), faeces (20-22%)</td> <td><a href="/wiki/CYP2D6" title="CYP2D6">CYP2D6</a> & <a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a></td> <td>96%</td> <td>2-4</td> <td>? </td></tr> <tr> <td><a href="/wiki/Lurasidone" title="Lurasidone">Lurasidone</a></td> <td>Oral</td> <td>18</td> <td>6173</td> <td>99%</td> <td>Faeces (80%), urine (9%)</td> <td><a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a></td> <td>9-19%</td> <td>1-3</td> <td>? </td></tr> <tr> <td><a href="/wiki/Melperone" title="Melperone">Melperone</a><a href="#cite_note-124">[119]</a><a href="#cite_note-125">[120]</a></td> <td>Oral, intramuscular</td> <td>3–4 (oral), 6 (IM)</td> <td>7–9.9</td> <td>50%</td> <td>Urine (70% as metabolites; 5–10.4% unchanged drug)</td> <td>?</td> <td>65% (tablet), 87% (IM), 54% (oral syrup)</td> <td>0.5–3</td> <td>75–324 (repeated dosing) </td></tr> <tr> <td><a href="/wiki/Olanzapine" title="Olanzapine">Olanzapine</a></td> <td>Oral, intramuscular (including depot)</td> <td>30</td> <td>1000</td> <td>93%</td> <td>Urine (57%), faeces (30%)</td> <td><a href="/wiki/CYP1A2" title="CYP1A2">CYP1A2</a>, <a href="/wiki/CYP2D6" title="CYP2D6">CYP2D6</a></td> <td>>60%</td> <td>6 (Oral)</td> <td>? </td></tr> <tr> <td><a href="/wiki/Paliperidone" title="Paliperidone">Paliperidone</a></td> <td>Oral, intramuscular (including depot)</td> <td>23 (Oral)</td> <td>390-487</td> <td>74%</td> <td>Urine (80%), faeces (11%)</td> <td><a href="/wiki/CYP2D6" title="CYP2D6">CYP2D6</a>, <a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a></td> <td>28%</td> <td>24 (Oral)</td> <td>? </td></tr> <tr> <td><a href="/wiki/Perospirone" title="Perospirone">Perospirone</a><a href="#cite_note-onrust-78">[78]</a></td> <td>Oral</td> <td>?</td> <td>?</td> <td>92%</td> <td>Urine (0.4% as unchanged drug)</td> <td>?</td> <td>?</td> <td>1.5</td> <td>1.9-5.7 </td></tr> <tr> <td><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a></td> <td>Oral</td> <td>6 (IR), 7 (XR)</td> <td>6-14</td> <td>83%</td> <td>Urine (73%), faeces (20%)</td> <td><a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a></td> <td>100%</td> <td>1.5 (IR), 6 (XR)</td> <td>? </td></tr> <tr> <td><a href="/wiki/Risperidone" title="Risperidone">Risperidone</a></td> <td>Oral, intramuscular (including depot)</td> <td>3 (EM) (oral), 20 (PM) (oral)</td> <td>1-2</td> <td>90%, 77% (metabolite)</td> <td>Urine (70%), faeces (14%)</td> <td><a href="/wiki/CYP2D6" title="CYP2D6">CYP2D6</a></td> <td>70%</td> <td>3 (EM), 17 (PM)</td> <td>? </td></tr> <tr> <td><a href="/wiki/Sertindole" title="Sertindole">Sertindole</a></td> <td>Oral</td> <td>72 (55–90)</td> <td>20</td> <td>99.5%</td> <td>Urine (4%), faeces (46-56%)</td> <td><a href="/wiki/CYP2D6" title="CYP2D6">CYP2D6</a></td> <td>74%</td> <td>10</td> <td>? </td></tr> <tr> <td><a href="/wiki/Ziprasidone" title="Ziprasidone">Ziprasidone</a></td> <td>Oral, intramuscular</td> <td>7 (oral)</td> <td>1.5</td> <td>99%</td> <td>Faeces (66%), urine (20%)</td> <td><a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a> & <a href="/wiki/CYP1A2" title="CYP1A2">CYP1A2</a></td> <td>60% (Oral), 100% (IM)</td> <td>6-8</td> <td>? </td></tr> <tr> <td><a href="/wiki/Zotepine" title="Zotepine">Zotepine</a><a href="#cite_note-126">[121]</a><a href="#cite_note-127">[122]</a></td> <td>Oral</td> <td>13.7-15.9</td> <td>10-109</td> <td>97%</td> <td>Urine (17%)</td> <td>?</td> <td>7-13%</td> <td>?</td> <td>? </td></tr> <tr> <td colspan="10"> Acronyms used: IR - Immediate release formulation. XR - Extended release formulation. EM - Extensive metabolisers. PM - Poor metabolisers. Cmax - maximum plasma concentrations of the drug. </td></tr></tbody></table> <table class="wikitable sortable mw-collapsible mw-collapsed" style="font-size:small; margin: 1em auto;"> <caption class="nowrap"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist 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dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Pharmacokinetics_of_long-acting_injectable_antipsychotics" title="Template:Pharmacokinetics of long-acting injectable antipsychotics"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Pharmacokinetics_of_long-acting_injectable_antipsychotics" title="Template talk:Pharmacokinetics of long-acting injectable antipsychotics"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Pharmacokinetics_of_long-acting_injectable_antipsychotics" title="Special:EditPage/Template:Pharmacokinetics of long-acting injectable antipsychotics"><abbr title="Edit this template">e</abbr></a></li></ul></div> Pharmacokinetics of long-acting injectable antipsychotics </caption> <tbody><tr> <th>Medication</th> <th>Brand name</th> <th>Class</th> <th>Vehicle</th> <th>Dosage</th> <th>Tmax</th> <th>t1/2 single</th> <th>t1/2 multiple</th> <th>logPc</th> <th>Ref </th></tr> <tr> <td><a href="/wiki/Aripiprazole_lauroxil" title="Aripiprazole lauroxil">Aripiprazole lauroxil</a></td> <td>Aristada</td> <td>Atypical</td> <td><a href="/wiki/Water" title="Water">Water</a>a</td> <td>441–1064 mg/4–8 weeks</td> <td>24–35 days</td> <td>?</td> <td>54–57 days</td> <td>7.9–10.0</td> <td> </td></tr> <tr> <td><a href="/wiki/Aripiprazole_monohydrate" class="mw-redirect" title="Aripiprazole monohydrate">Aripiprazole monohydrate</a></td> <td>Abilify Maintena</td> <td>Atypical</td> <td><a href="/wiki/Water" title="Water">Water</a>a</td> <td>300–400 mg/4 weeks</td> <td>7 days</td> <td>?</td> <td>30–47 days</td> <td>4.9–5.2</td> <td> </td></tr> <tr> <td><a href="/wiki/Bromperidol_decanoate" title="Bromperidol decanoate">Bromperidol decanoate</a></td> <td>Impromen Decanoas</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Sesame_oil" title="Sesame oil">Sesame oil</a></td> <td>40–300 mg/4 weeks</td> <td>3–9 days</td> <td>?</td> <td>21–25 days</td> <td>7.9</td> <td><a href="#cite_note-ParentToussaint1983-128">[123]</a> </td></tr> <tr> <td><a href="/wiki/Clopentixol_decanoate" class="mw-redirect" title="Clopentixol decanoate">Clopentixol decanoate</a></td> <td>Sordinol Depot</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Viscoleo" title="Viscoleo">Viscoleo</a>b</td> <td>50–600 mg/1–4 weeks</td> <td>4–7 days</td> <td>?</td> <td>19 days</td> <td>9.0</td> <td><a href="#cite_note-pmid6931472-129">[124]</a> </td></tr> <tr> <td><a href="/wiki/Flupentixol_decanoate" class="mw-redirect" title="Flupentixol decanoate">Flupentixol decanoate</a></td> <td>Depixol</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Viscoleo" title="Viscoleo">Viscoleo</a>b</td> <td>10–200 mg/2–4 weeks</td> <td>4–10 days</td> <td>8 days</td> <td>17 days</td> <td>7.2–9.2</td> <td><a href="#cite_note-pmid6931472-129">[124]</a><a href="#cite_note-Reynolds1993-130">[125]</a> </td></tr> <tr> <td><a href="/wiki/Fluphenazine_decanoate" class="mw-redirect" title="Fluphenazine decanoate">Fluphenazine decanoate</a></td> <td>Prolixin Decanoate</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Sesame_oil" title="Sesame oil">Sesame oil</a></td> <td>12.5–100 mg/2–5 weeks</td> <td>1–2 days</td> <td>1–10 days</td> <td>14–100 days</td> <td>7.2–9.0</td> <td><a href="#cite_note-pmid6143748-131">[126]</a><a href="#cite_note-pmid444352-132">[127]</a><a href="#cite_note-YoungEreshefsky1984-133">[128]</a> </td></tr> <tr> <td><a href="/wiki/Fluphenazine_enanthate" class="mw-redirect" title="Fluphenazine enanthate">Fluphenazine enanthate</a></td> <td>Prolixin Enanthate</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Sesame_oil" title="Sesame oil">Sesame oil</a></td> <td>12.5–100 mg/1–4 weeks</td> <td>2–3 days</td> <td>4 days</td> <td>?</td> <td>6.4–7.4</td> <td><a href="#cite_note-pmid444352-132">[127]</a> </td></tr> <tr> <td><a href="/wiki/Fluspirilene" title="Fluspirilene">Fluspirilene</a></td> <td>Imap, Redeptin</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Water" title="Water">Water</a>a</td> <td>2–12 mg/1 week</td> <td>1–8 days</td> <td>7 days</td> <td>?</td> <td>5.2–5.8</td> <td><a href="#cite_note-pmid4992598-134">[129]</a> </td></tr> <tr> <td><a href="/wiki/Haloperidol_decanoate" title="Haloperidol decanoate">Haloperidol decanoate</a></td> <td>Haldol Decanoate</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Sesame_oil" title="Sesame oil">Sesame oil</a></td> <td>20–400 mg/2–4 weeks</td> <td>3–9 days</td> <td colspan="2">18–21 days</td> <td>7.2–7.9</td> <td><a href="#cite_note-pmid3545764-135">[130]</a><a href="#cite_note-pmid7185768-136">[131]</a> </td></tr> <tr> <td><a href="/wiki/Olanzapine_pamoate" class="mw-redirect" title="Olanzapine pamoate">Olanzapine pamoate</a></td> <td>Zyprexa Relprevv</td> <td>Atypical</td> <td><a href="/wiki/Water" title="Water">Water</a>a</td> <td>150–405 mg/2–4 weeks</td> <td>7 days</td> <td>?</td> <td>30 days</td> <td>–</td> <td> </td></tr> <tr> <td><a href="/wiki/Oxyprothepin_decanoate" title="Oxyprothepin decanoate">Oxyprothepin decanoate</a></td> <td>Meclopin</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td>?</td> <td>?</td> <td>?</td> <td>?</td> <td>?</td> <td>8.5–8.7</td> <td> </td></tr> <tr> <td><a href="/wiki/Paliperidone_palmitate" class="mw-redirect" title="Paliperidone palmitate">Paliperidone palmitate</a></td> <td>Invega Sustenna</td> <td>Atypical</td> <td><a href="/wiki/Water" title="Water">Water</a>a</td> <td>39–819 mg/4–12 weeks</td> <td>13–33 days</td> <td>25–139 days</td> <td>?</td> <td>8.1–10.1</td> <td> </td></tr> <tr> <td><a href="/wiki/Perphenazine_decanoate" class="mw-redirect" title="Perphenazine decanoate">Perphenazine decanoate</a></td> <td>Trilafon Dekanoat</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Sesame_oil" title="Sesame oil">Sesame oil</a></td> <td>50–200 mg/2–4 weeks</td> <td>?</td> <td>?</td> <td>27 days</td> <td>8.9</td> <td> </td></tr> <tr> <td><a href="/wiki/Perphenazine_enanthate" title="Perphenazine enanthate">Perphenazine enanthate</a></td> <td>Trilafon Enanthate</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Sesame_oil" title="Sesame oil">Sesame oil</a></td> <td>25–200 mg/2 weeks</td> <td>2–3 days</td> <td>?</td> <td>4–7 days</td> <td>6.4–7.2</td> <td><a href="#cite_note-LarssonAxelsson1984-137">[132]</a> </td></tr> <tr> <td><a href="/wiki/Pipotiazine_palmitate" class="mw-redirect" title="Pipotiazine palmitate">Pipotiazine palmitate</a></td> <td>Piportil Longum</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Viscoleo" title="Viscoleo">Viscoleo</a>b</td> <td>25–400 mg/4 weeks</td> <td>9–10 days</td> <td>?</td> <td>14–21 days</td> <td>8.5–11.6</td> <td><a href="#cite_note-Reynolds1993-130">[125]</a> </td></tr> <tr> <td><a href="/wiki/Pipotiazine_undecylenate" class="mw-redirect" title="Pipotiazine undecylenate">Pipotiazine undecylenate</a></td> <td>Piportil Medium</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Sesame_oil" title="Sesame oil">Sesame oil</a></td> <td>100–200 mg/2 weeks</td> <td>?</td> <td>?</td> <td>?</td> <td>8.4</td> <td> </td></tr> <tr> <td><a href="/wiki/Risperidone" title="Risperidone">Risperidone</a></td> <td>Risperdal Consta</td> <td>Atypical</td> <td><a href="/wiki/Microsphere" class="mw-redirect" title="Microsphere">Microspheres</a></td> <td>12.5–75 mg/2 weeks</td> <td>21 days</td> <td>?</td> <td>3–6 days</td> <td>–</td> <td> </td></tr> <tr> <td><a href="/wiki/Zuclopentixol_acetate" class="mw-redirect" title="Zuclopentixol acetate">Zuclopentixol acetate</a></td> <td>Clopixol Acuphase</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Viscoleo" title="Viscoleo">Viscoleo</a>b</td> <td>50–200 mg/1–3 days</td> <td>1–2 days</td> <td colspan="2">1–2 days</td> <td>4.7–4.9</td> <td> </td></tr> <tr> <td><a href="/wiki/Zuclopentixol_decanoate" class="mw-redirect" title="Zuclopentixol decanoate">Zuclopentixol decanoate</a></td> <td>Clopixol Depot</td> <td><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></td> <td><a href="/wiki/Viscoleo" title="Viscoleo">Viscoleo</a>b</td> <td>50–800 mg/2–4 weeks</td> <td>4–9 days</td> <td>?</td> <td>11–21 days</td> <td>7.5–9.0</td> <td> </td></tr> <tr class="sortbottom"> <td colspan="10" style="width: 1px; background-color:#eaecf0; background-color:#eaecf0; text-align: center;">Note: All by <a href="/wiki/Intramuscular_injection" title="Intramuscular injection">intramuscular injection</a>. Footnotes: a = <a href="/wiki/Microcrystalline" title="Microcrystalline">Microcrystalline</a> or <a href="/wiki/Nanocrystalline" class="mw-redirect" title="Nanocrystalline">nanocrystalline</a> <a href="/wiki/Aqueous_suspension" class="mw-redirect" title="Aqueous suspension">aqueous suspension</a>. b = Low-<a href="/wiki/Viscosity" title="Viscosity">viscosity</a> <a href="/wiki/Vegetable_oil" title="Vegetable oil">vegetable oil</a> (specifically <a href="/wiki/Fractionated_coconut_oil" class="mw-redirect" title="Fractionated coconut oil">fractionated coconut oil</a> with <a href="/wiki/Medium-chain_triglyceride" title="Medium-chain triglyceride">medium-chain triglycerides</a>). c = Predicted, from <a href="/wiki/PubChem" title="PubChem">PubChem</a> and <a href="/wiki/DrugBank" title="DrugBank">DrugBank</a>. Sources: Main: See template. </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="History">History</h2>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=23" title="Edit section: History">edit</a>]</div> The first major tranquilizer or antipsychotic medication, <a href="/wiki/Chlorpromazine" title="Chlorpromazine">chlorpromazine</a> (Thorazine), a typical antipsychotic, was discovered in 1951 and introduced into clinical practice shortly thereafter. Clozapine (Clozaril), an atypical antipsychotic, fell out of favor due to concerns over drug-induced <a href="/wiki/Agranulocytosis" title="Agranulocytosis">agranulocytosis</a>. Following research indicating its effectiveness in treatment-resistant <a href="/wiki/Schizophrenia" title="Schizophrenia">schizophrenia</a> and the development of an adverse event monitoring system, clozapine re-emerged as a viable antipsychotic. According to Barker (2003), the three most-accepted atypical drugs are clozapine, risperidone, and olanzapine. However, he goes on to explain that clozapine is usually the last resort when other drugs fail. Clozapine can cause agranulocytosis (a decreased number of white blood cells), requiring blood monitoring for the patient. Despite the effectiveness of clozapine for treatment-resistant schizophrenia, agents with a more favorable side-effect profile were sought for widespread use. During the 1990s, <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a>, <a href="/wiki/Risperidone" title="Risperidone">risperidone</a>, and <a href="/wiki/Quetiapine" title="Quetiapine">quetiapine</a> were introduced, with <a href="/wiki/Ziprasidone" title="Ziprasidone">ziprasidone</a> and <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a> following in the early 2000s. The atypical antipsychotic <a href="/wiki/Paliperidone" title="Paliperidone">paliperidone</a> was approved by the FDA in late 2006.<a href="#cite_note-138">[133]</a> The atypical antipsychotic <a href="/wiki/Asenapine" title="Asenapine">asenapine</a> (Saphris) was approved by the FDA in 2009.<a href="#cite_note-139">[134]</a> The atypical antipsychotics have found favor among clinicians and are now considered to be <a href="/wiki/First-line_treatment" class="mw-redirect" title="First-line treatment">first-line treatments</a> for schizophrenia and are gradually replacing the <a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">typical antipsychotics</a>. In the past, most researchers have agreed that the defining characteristics of atypical antipsychotics are the decreased incidence of <a href="/wiki/Extrapyramidal_symptoms" title="Extrapyramidal symptoms">extrapyramidal</a> side effects (EPS)<a href="#cite_note-pmid16498489-140">[135]</a> and an absence of sustained prolactin elevation.<a href="#cite_note-pmid11873706-55">[55]</a> The terminology can still be imprecise. The definition of "atypicality" was based upon the absence of extrapyramidal side effects, but there is now a clear understanding that atypical antipsychotics can still induce these effects (though to a lesser degree than typical antipsychotics).<a href="#cite_note-pmid17242588-141">[136]</a> Recent literature focuses more upon specific pharmacological actions and less upon categorization of an agent as "typical" or "atypical". There is no clear dividing line between the typical and atypical antipsychotics therefore categorization based on the action is difficult.<a href="#cite_note-pmid11873706-55">[55]</a> More recent research is questioning the notion that second-generation antipsychotics are superior to first generation typical antipsychotics. Using a number of parameters to assess quality of life, <a href="/wiki/University_of_Manchester" title="University of Manchester">Manchester University</a> researchers found that typical antipsychotics were no worse than atypical antipsychotics. The research was funded by the <a href="/wiki/National_Health_Service" title="National Health Service">National Health Service</a> (NHS) of the UK.<a href="#cite_note-pmid17015810-142">[137]</a> Because each medication (whether first or second generation) has its own profile of desirable and adverse effects, a neuropsychopharmacologist may recommend one of the older ("typical" or first generation) or newer ("atypical" or second generation) antipsychotics alone or in combination with other medications, based on the symptom profile, response pattern, and adverse effects history of the individual patient. <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=24" title="Edit section: Society and culture">edit</a>]</div> Between May 2007 and April 2008, 5.5 million Americans filled at least one prescription for an atypical antipsychotic.<a href="#cite_note-pmid19727265-46">[46]</a> In patients under the age of 65, 71% of patients were prescribed an atypical antipsychotic to treat Schizophrenia or Bipolar Disorder where this dropped to 38% in patients aged 65 or above.<a href="#cite_note-pmid19727265-46">[46]</a> Despite the name "antipsychotics", the drugs are commonly used for a variety of conditions that do not involve <a href="/wiki/Psychosis" title="Psychosis">psychosis</a>. Some healthcare professionals reported avoiding the name "atypical antipsychotic" when prescribing the drug to patients who had bipolar disorder.<a href="#cite_note-143">[138]</a> <div class="mw-heading mw-heading3"><h3 id="Regulatory_status">Regulatory status</h3>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=25" title="Edit section: Regulatory status">edit</a>]</div> <table class="wikitable collapsible collapsed" style="width:100%"> <tbody><tr> <th colspan="15">Regulatory status of second-generation antipsychotics (SGAs) as of July 2013<a class="external text" href="https://en.wikipedia.org/w/index.php?title=Atypical_antipsychotic&action=edit">[update]</a> </th></tr> <tr> <th>Generic name</th> <th><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style>United States <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">FDA</a> approved</th> <th><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488" />Canada <a href="/wiki/Health_Products_and_Food_Branch" title="Health Products and Food Branch">HPFB</a> approved<a href="#cite_note-144">[139]</a></th> <th><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488" />Australia <a href="/wiki/Therapeutic_Goods_Administration" title="Therapeutic Goods Administration">TGA</a> approved<a href="#cite_note-145">[140]</a></th> <th><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488" />Europe <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">EMA</a> approved<a href="#cite_note-ema-146">[141]</a></th> <th><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488" />Japan <a href="/wiki/Pharmaceuticals_and_Medical_Devices_Agency" title="Pharmaceuticals and Medical Devices Agency">PMDA</a> approved<a href="#cite_note-147">[142]</a></th> <th><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488" />United Kingdom <a href="/wiki/Medicines_and_Healthcare_products_Regulatory_Agency" title="Medicines and Healthcare products Regulatory Agency">MHRA</a> approved<a href="#cite_note-148">[143]</a><a href="#cite_note-149">[144]</a><a href="#cite_note-ema-146">[141]</a> </th></tr> <tr> <td><a href="/wiki/Amisulpride" title="Amisulpride">Amisulpride</a></td> <td>No</td> <td>No</td> <td>Yes</td> <td>(some members)</td> <td>No</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Aripiprazole" title="Aripiprazole">Aripiprazole</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Asenapine" title="Asenapine">Asenapine</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Blonanserin" title="Blonanserin">Blonanserin</a></td> <td>No</td> <td>No</td> <td>No</td> <td>No</td> <td>Yes</td> <td>No </td></tr> <tr> <td><a href="/wiki/Carpipramine" title="Carpipramine">Carpipramine</a></td> <td>No</td> <td>No</td> <td>No</td> <td>No</td> <td>Yes</td> <td>No </td></tr> <tr> <td><a href="/wiki/Clocapramine" title="Clocapramine">Clocapramine</a></td> <td>No</td> <td>No</td> <td>No</td> <td>No</td> <td>Yes</td> <td>No </td></tr> <tr> <td><a href="/wiki/Clozapine" title="Clozapine">Clozapine</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Iloperidone" title="Iloperidone">Iloperidone</a></td> <td>Yes</td> <td>No</td> <td>No</td> <td>Refused</td> <td>No</td> <td>No </td></tr> <tr> <td><a href="/wiki/Lurasidone" title="Lurasidone">Lurasidone</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>No</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Melperone" title="Melperone">Melperone</a></td> <td>No</td> <td>No</td> <td>No</td> <td>No</td> <td>No</td> <td>No </td></tr> <tr> <td><a href="/wiki/Mosapramine" title="Mosapramine">Mosapramine</a></td> <td>No</td> <td>No</td> <td>No</td> <td>No</td> <td>Yes</td> <td>No </td></tr> <tr> <td><a href="/wiki/Olanzapine" title="Olanzapine">Olanzapine</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Paliperidone" title="Paliperidone">Paliperidone</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Perospirone" title="Perospirone">Perospirone</a></td> <td>No</td> <td>No</td> <td>No</td> <td>No</td> <td>Yes</td> <td>No </td></tr> <tr> <td><a href="/wiki/Pimavanserin" title="Pimavanserin">Pimavanserin</a></td> <td>Yes</td> <td>No</td> <td>No</td> <td>Investigational</td> <td>No</td> <td>(No) </td></tr> <tr> <td><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Remoxipride" title="Remoxipride">Remoxipride</a></td> <td>No</td> <td>No</td> <td>No</td> <td>Withdrawn</td> <td>No</td> <td>No </td></tr> <tr> <td><a href="/wiki/Risperidone" title="Risperidone">Risperidone</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Sertindole" title="Sertindole">Sertindole</a></td> <td>No</td> <td>No</td> <td>No</td> <td>Yes</td> <td>No</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Sulpiride" title="Sulpiride">Sulpiride</a></td> <td>No</td> <td>No</td> <td>No</td> <td>Yes</td> <td>Yes</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Ziprasidone" title="Ziprasidone">Ziprasidone</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>(some members)</td> <td>No</td> <td>Yes </td></tr> <tr> <td><a href="/wiki/Zotepine" title="Zotepine">Zotepine</a></td> <td>No</td> <td>No</td> <td>No</td> <td>No</td> <td>Yes</td> <td>No </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Notes">Notes</h2>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=26" title="Edit section: Notes">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-121"><a href="#cite_ref-121">^</a> The route of administration in this category refers to the standard means of administration when the drug is being used in its capacity as an atypical antipsychotic, not for other purposes. For example, amisulpride can be administered intravenously as an antiemetic drug but this is not its standard route of administration when being used as an antipsychotic </li> <li id="cite_note-122"><a href="#cite_ref-122">^</a> Note these values are from a study in of which amisulpride was intravenously administered </li> </ol></div></div> Stahl: AP Explained 1 <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239543626" /><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-S1-87">^ <a href="#cite_ref-S1_87-0">a</a> <a href="#cite_ref-S1_87-1">b</a> p. 329-336.<a href="#cite_note-Stahl_AP_Explained_1-86">[86]</a> </li> <li id="cite_note-S2-88">^ <a href="#cite_ref-S2_88-0">a</a> <a href="#cite_ref-S2_88-1">b</a> <a href="#cite_ref-S2_88-2">c</a> p. 346-352.<a href="#cite_note-Stahl_AP_Explained_1-86">[86]</a> </li> <li id="cite_note-S3-89">^ <a href="#cite_ref-S3_89-0">a</a> <a href="#cite_ref-S3_89-1">b</a> <a href="#cite_ref-S3_89-2">c</a> <a href="#cite_ref-S3_89-3">d</a> p. 355-360.<a href="#cite_note-Stahl_AP_Explained_1-86">[86]</a> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=27" title="Edit section: See also">edit</a>]</div> <ul><li><a href="/wiki/List_of_antidepressants" title="List of antidepressants">List of antidepressants</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=28" title="Edit section: References">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239543626" /><div class="reflist reflist-columns references-column-width" style="column-width: 30em;"> <ol class="references"> <li id="cite_note-Miyake-1"><a href="#cite_ref-Miyake_1-0">^</a> <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFMiyakeMiyamotoJarskog2012" class="citation journal cs1">Miyake N, Miyamoto S, Jarskog LF (October 2012). 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Retrieved February 2, 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Australian+Government+Department+of+Health%2C+Therapeutic+Goods+Administration&rft.atitle=Search+the+TGA+website&rft_id=http%3A%2F%2Ftga-search.clients.funnelback.com%2Fs%2Fsearch.html%3Fquery%3D%26collection%3Dtga-artg&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtypical+antipsychotic" class="Z3988"> </li> <li id="cite_note-ema-146">^ <a href="#cite_ref-ema_146-0">a</a> <a href="#cite_ref-ema_146-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20120526074920/http://www.ema.europa.eu/ema/">"European Medicines Agency: Search"</a>. European Medicines Agency. Archived from <a rel="nofollow" class="external text" href="http://www.ema.europa.eu/ema/">the original</a> on May 26, 2012. Retrieved February 2, 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=European+Medicines+Agency&rft.atitle=European+Medicines+Agency%3A+Search&rft_id=http%3A%2F%2Fwww.ema.europa.eu%2Fema%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtypical+antipsychotic" class="Z3988"> Search </li> <li id="cite_note-147"><a href="#cite_ref-147">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20181116051537/http://ss.pmda.go.jp/en_all/search.x?q%3DSearch">"Search"</a>. Pharmaceuticals and Medical Devices Agency. Archived from <a rel="nofollow" class="external text" href="http://ss.pmda.go.jp/en_all/search.x?q=Search">the original</a> on November 16, 2018. Retrieved February 2, 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Pharmaceuticals+and+Medical+Devices+Agency&rft.atitle=Search&rft_id=http%3A%2F%2Fss.pmda.go.jp%2Fen_all%2Fsearch.x%3Fq%3DSearch&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtypical+antipsychotic" class="Z3988"> </li> <li id="cite_note-148"><a href="#cite_ref-148">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.mhra.gov.uk/spc-pil/">"Medicines Information: SPC & PILs"</a>. Medicines and Healthcare products Regulatory Agency. Retrieved February 2, 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Medicines+and+Healthcare+products+Regulatory+Agency&rft.atitle=Medicines+Information%3A+SPC+%26+PILs&rft_id=http%3A%2F%2Fwww.mhra.gov.uk%2Fspc-pil%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtypical+antipsychotic" class="Z3988"> </li> <li id="cite_note-149"><a href="#cite_ref-149">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.gov.uk/government/publications/antipsychotic-medicines-licensed-products-uses-and-side-effects/antipsychotic-medicines">"Guidance: Antipsychotic medicines"</a>. Medicines & Healthcare products Regulatory Agency. August 25, 2005. Retrieved February 2, 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Medicines+%26+Healthcare+products+Regulatory+Agency&rft.atitle=Guidance%3A+Antipsychotic+medicines&rft.date=2005-08-25&rft_id=https%3A%2F%2Fwww.gov.uk%2Fgovernment%2Fpublications%2Fantipsychotic-medicines-licensed-products-uses-and-side-effects%2Fantipsychotic-medicines&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtypical+antipsychotic" class="Z3988"> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=29" title="Edit section: Further reading">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFElmorsySmith2015" class="citation journal cs1">Elmorsy E, Smith PA (May 2015). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180722092306/http://eprints.nottingham.ac.uk/43322/8/Bioen%20BBSRC_final.pdf">"Bioenergetic disruption of human micro-vascular endothelial cells by antipsychotics"</a> (PDF). Biochemical and Biophysical Research Communications. 460 (3): 857–62. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bbrc.2015.03.122">10.1016/j.bbrc.2015.03.122</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25824037">25824037</a>. Archived from <a rel="nofollow" class="external text" href="http://eprints.nottingham.ac.uk/43322/8/Bioen%20BBSRC_final.pdf">the original</a> (PDF) on July 22, 2018. Retrieved December 14, 2019.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Bioenergetic+disruption+of+human+micro-vascular+endothelial+cells+by+antipsychotics&rft.volume=460&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E857-%3C%2Fspan%3E62&rft.date=2015-05&rft_id=info%3Adoi%2F10.1016%2Fj.bbrc.2015.03.122&rft_id=info%3Apmid%2F25824037&rft.aulast=Elmorsy&rft.aufirst=E&rft.au=Smith%2C+PA&rft_id=http%3A%2F%2Feprints.nottingham.ac.uk%2F43322%2F8%2FBioen%2520BBSRC_final.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtypical+antipsychotic" class="Z3988"></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSimpson2005" class="citation journal cs1">Simpson GM (September 2005). "Atypical antipsychotics and the burden of disease". The American Journal of Managed Care. 11 (8 Suppl): S235-41. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16180961">16180961</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+American+Journal+of+Managed+Care&rft.atitle=Atypical+antipsychotics+and+the+burden+of+disease&rft.volume=11&rft.issue=8+Suppl&rft.pages=S235-41&rft.date=2005-09&rft_id=info%3Apmid%2F16180961&rft.aulast=Simpson&rft.aufirst=GM&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtypical+antipsychotic" class="Z3988"></li> <li><a rel="nofollow" class="external text" href="https://www.usatoday.com/news/health/2006-05-01-atypical-drugs_x.htm">New antipsychotic drugs carry risks for children (USA Today 2006)</a></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20130902024224/http://www.nih.gov/news/pr/sep2005/nimh-19.htm">"NIMH Study to Guide Treatment Choices for Schizophrenia"</a> (Press release). <a href="/wiki/National_Institute_of_Mental_Health" title="National Institute of Mental Health">National Institute of Mental Health</a>. September 19, 2005. Archived from <a rel="nofollow" class="external text" href="http://www.nih.gov/news/pr/sep2005/nimh-19.htm">the original</a> on September 2, 2013. Retrieved August 18, 2013.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=NIMH+Study+to+Guide+Treatment+Choices+for+Schizophrenia&rft.pub=National+Institute+of+Mental+Health&rft.date=2005-09-19&rft_id=http%3A%2F%2Fwww.nih.gov%2Fnews%2Fpr%2Fsep2005%2Fnimh-19.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtypical+antipsychotic" class="Z3988"></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2>[<a href="/w/index.php?title=Atypical_antipsychotic&action=edit&section=30" title="Edit section: External links">edit</a>]</div> <ul><li><a href="/wiki/File:Commons-logo.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/20px-Commons-logo.svg.png" decoding="async" width="12" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/40px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a> Media related to <a href="https://commons.wikimedia.org/wiki/Category:Atypical_antipsychotics" class="extiw" title="commons:Category:Atypical antipsychotics">Atypical antipsychotics</a> at Wikimedia Commons</li></ul> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output 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rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Antipsychotics" title="Template:Antipsychotics"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Antipsychotics" title="Template talk:Antipsychotics"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Antipsychotics" title="Special:EditPage/Template:Antipsychotics"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Antipsychotics_(N05A)453" style="font-size:114%;margin:0 4em"><a href="/wiki/Antipsychotic" title="Antipsychotic">Antipsychotics</a> (<a href="/wiki/ATC_code_N05#N05A" title="ATC code N05">N05A</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Butyrophenone" title="Butyrophenone">Butyrophenones</a>: <a href="/wiki/Benperidol" title="Benperidol">Benperidol</a></li> <li><a href="/wiki/Bromperidol" title="Bromperidol">Bromperidol</a> <ul><li><a href="/wiki/Bromperidol_decanoate" title="Bromperidol decanoate">Bromperidol decanoate</a></li></ul></li> <li><a href="/wiki/Droperidol" title="Droperidol">Droperidol</a></li> <li><a href="/wiki/Haloperidol" title="Haloperidol">Haloperidol</a># <ul><li><a href="/wiki/Haloperidol_decanoate" title="Haloperidol decanoate">Haloperidol decanoate</a></li></ul></li> <li><a href="/wiki/Moperone" title="Moperone">Moperone</a></li> <li><a href="/wiki/Pipamperone" title="Pipamperone">Pipamperone</a></li> <li><a href="/wiki/Spiperone" title="Spiperone">Spiperone</a></li> <li><a href="/wiki/Timiperone" title="Timiperone">Timiperone</a></li> <li><a href="/wiki/Trifluperidol" title="Trifluperidol">Trifluperidol</a></li></ul> <ul><li><a href="/wiki/Diphenylbutylpiperidine" title="Diphenylbutylpiperidine">Diphenylbutylpiperidines</a>: <a href="/wiki/Fluspirilene" title="Fluspirilene">Fluspirilene</a></li> <li><a href="/wiki/Penfluridol" title="Penfluridol">Penfluridol</a></li> <li><a href="/wiki/Pimozide" title="Pimozide">Pimozide</a></li></ul> <ul><li><a href="/wiki/Phenothiazine" title="Phenothiazine">Phenothiazines</a>: <a href="/wiki/Acepromazine" title="Acepromazine">Acepromazine</a></li> <li><a href="/wiki/Acetophenazine" title="Acetophenazine">Acetophenazine</a></li> <li><a href="/wiki/Butaperazine" title="Butaperazine">Butaperazine</a></li> <li><a href="/wiki/Carfenazine" title="Carfenazine">Carphenazine (carfenazine)</a>‡</li> <li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Cyamemazine" title="Cyamemazine">Cyamemazine</a></li> <li><a href="/wiki/Dixyrazine" title="Dixyrazine">Dixyrazine</a></li> <li><a href="/wiki/Fluphenazine" title="Fluphenazine">Fluphenazine</a> <ul><li><a href="/wiki/Fluphenazine_decanoate" class="mw-redirect" title="Fluphenazine decanoate">Fluphenazine decanoate</a></li> <li><a href="/wiki/Fluphenazine_enanthate" class="mw-redirect" title="Fluphenazine enanthate">Fluphenazine enanthate</a></li></ul></li> <li><a href="/wiki/Levomepromazine" title="Levomepromazine">Levomepromazine (methotrimeprazine)</a></li> <li><a href="/wiki/Mesoridazine" title="Mesoridazine">Mesoridazine</a></li> <li><a href="/wiki/Perazine" title="Perazine">Perazine</a></li> <li><a href="/wiki/Periciazine" title="Periciazine">Periciazine</a></li> <li><a href="/wiki/Perphenazine" title="Perphenazine">Perphenazine</a> <ul><li><a href="/wiki/BL-1020" title="BL-1020">BL-1020</a></li> <li><a href="/wiki/Perphenazine_decanoate" class="mw-redirect" title="Perphenazine decanoate">Perphenazine decanoate</a></li> <li><a href="/wiki/Perphenazine_enanthate" title="Perphenazine enanthate">Perphenazine enanthate</a></li></ul></li> <li><a href="/wiki/Piperacetazine" title="Piperacetazine">Piperacetazine</a></li> <li><a href="/wiki/Pipotiazine" title="Pipotiazine">Pipotiazine</a> <ul><li><a href="/wiki/Pipotiazine_palmitate" class="mw-redirect" title="Pipotiazine palmitate">Pipotiazine palmitate</a></li> <li><a href="/wiki/Pipotiazine_undecylenate" class="mw-redirect" title="Pipotiazine undecylenate">Pipotiazine undecylenate</a></li></ul></li> <li><a href="/wiki/Prochlorperazine" title="Prochlorperazine">Prochlorperazine</a></li> <li><a href="/wiki/Promazine" title="Promazine">Promazine</a></li> <li><a href="/wiki/Sulforidazine" title="Sulforidazine">Sulforidazine</a></li> <li><a href="/wiki/Thiopropazate" title="Thiopropazate">Thiopropazate</a></li> <li><a href="/wiki/Thioproperazine" title="Thioproperazine">Thioproperazine</a></li> <li><a href="/wiki/Thioridazine" title="Thioridazine">Thioridazine</a></li> <li><a href="/wiki/Trifluoperazine" title="Trifluoperazine">Trifluoperazine</a></li> <li><a href="/wiki/Triflupromazine" title="Triflupromazine">Triflupromazine</a></li></ul> <ul><li><a href="/wiki/Thioxanthene" title="Thioxanthene">Thioxanthenes</a>: <a href="/wiki/Chlorprothixene" title="Chlorprothixene">Chlorprothixene</a></li> <li><a href="/wiki/Clopenthixol" title="Clopenthixol">Clopenthixol</a> <ul><li><a href="/wiki/Clopenthixol_decanoate" class="mw-redirect" title="Clopenthixol decanoate">Clopenthixol decanoate</a></li></ul></li> <li><a href="/wiki/Flupentixol" title="Flupentixol">Flupentixol</a> <ul><li><a href="/wiki/Flupentixol_decanoate" class="mw-redirect" title="Flupentixol decanoate">Flupentixol decanoate</a></li></ul></li> <li><a href="/wiki/Tiotixene" title="Tiotixene">Tiotixene (thiothixene)</a></li> <li><a href="/wiki/Zuclopenthixol" title="Zuclopenthixol">Zuclopenthixol</a> <ul><li><a href="/wiki/Zuclopenthixol_acetate" class="mw-redirect" title="Zuclopenthixol acetate">Zuclopenthixol acetate</a></li> <li><a href="/wiki/Zuclopenthixol_decanoate" class="mw-redirect" title="Zuclopenthixol decanoate">Zuclopenthixol decanoate</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Disputed</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Benzamide" title="Benzamide">Benzamides</a>: <a href="/wiki/Amisulpride" title="Amisulpride">Amisulpride</a></li> <li><a href="/wiki/Levosulpiride" title="Levosulpiride">Levosulpiride</a></li> <li><a href="/wiki/Nemonapride" title="Nemonapride">Nemonapride</a></li> <li><a href="/wiki/Remoxipride" title="Remoxipride">Remoxipride</a>‡</li> <li><a href="/wiki/Sulpiride" title="Sulpiride">Sulpiride</a></li> <li><a href="/wiki/Sultopride" title="Sultopride">Sultopride</a></li> <li><a href="/wiki/Tiapride" title="Tiapride">Tiapride</a></li> <li><a href="/wiki/Veralipride" title="Veralipride">Veralipride</a>‡</li></ul> <ul><li><a href="/wiki/Butyrophenone" title="Butyrophenone">Butyrophenones</a>: <a href="/wiki/Melperone" title="Melperone">Melperone</a></li></ul> <ul><li><a href="/wiki/Tricyclic" title="Tricyclic">Tricyclics</a>: <a href="/wiki/Carpipramine" title="Carpipramine">Carpipramine</a></li> <li><a href="/wiki/Clocapramine" title="Clocapramine">Clocapramine</a></li> <li><a href="/wiki/Clorotepine" title="Clorotepine">Clorotepine</a></li> <li><a href="/wiki/Clotiapine" title="Clotiapine">Clotiapine</a></li> <li><a href="/wiki/Loxapine" title="Loxapine">Loxapine</a></li> <li><a href="/wiki/Mosapramine" title="Mosapramine">Mosapramine</a></li> <li><a href="/wiki/Oxyprothepin_decanoate" title="Oxyprothepin decanoate">Oxyprothepin decanoate</a></li></ul> <ul><li>Others: <a href="/wiki/Molindone" title="Molindone">Molindone</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a class="mw-selflink selflink">Atypical</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Benzisoxazole" title="Benzisoxazole">Benzisoxazole</a>/<a href="/wiki/Benzisothiazole" class="mw-redirect" title="Benzisothiazole">benzisothiazoles</a>: <a href="/wiki/Iloperidone" title="Iloperidone">Iloperidone</a></li> <li><a href="/wiki/Lurasidone" title="Lurasidone">Lurasidone</a></li> <li><a href="/wiki/Paliperidone" title="Paliperidone">Paliperidone</a> <ul><li><a href="/wiki/Paliperidone_palmitate" class="mw-redirect" title="Paliperidone palmitate">Paliperidone palmitate</a></li></ul></li> <li><a href="/wiki/Perospirone" title="Perospirone">Perospirone</a></li> <li><a href="/wiki/Risperidone" title="Risperidone">Risperidone</a>#</li> <li><a href="/wiki/Ziprasidone" title="Ziprasidone">Ziprasidone</a></li></ul> <ul><li><a href="/wiki/Butyrophenone" title="Butyrophenone">Butyrophenones</a>: <a href="/wiki/Lumateperone" title="Lumateperone">Lumateperone</a></li></ul> <ul><li><a href="/wiki/Phenylpiperazine" title="Phenylpiperazine">Phenylpiperazines</a>/<a href="/wiki/Quinolinone" class="mw-redirect" title="Quinolinone">quinolinones</a>: <a href="/wiki/Aripiprazole" title="Aripiprazole">Aripiprazole</a> <ul><li><a href="/wiki/Aripiprazole_lauroxil" title="Aripiprazole lauroxil">Aripiprazole lauroxil</a></li></ul></li> <li><a href="/wiki/Brilaroxazine" title="Brilaroxazine">Brilaroxazine</a>†</li> <li><a href="/wiki/Brexpiprazole" title="Brexpiprazole">Brexpiprazole</a></li> <li><a href="/wiki/Cariprazine" title="Cariprazine">Cariprazine</a></li></ul> <ul><li><a href="/wiki/Tricyclic" title="Tricyclic">Tricyclics</a>: <a href="/wiki/Asenapine" title="Asenapine">Asenapine</a></li> <li><a href="/wiki/Clozapine" title="Clozapine">Clozapine</a>#</li> <li><a href="/wiki/Olanzapine" title="Olanzapine">Olanzapine</a> (<a href="/wiki/Olanzapine/samidorphan" title="Olanzapine/samidorphan">+samidorphan</a>)</li> <li><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a></li> <li><a href="/wiki/Zotepine" title="Zotepine">Zotepine</a></li></ul> <ul><li>Others: <a href="/wiki/Blonanserin" title="Blonanserin">Blonanserin</a></li> <li><a href="/wiki/Pimavanserin" title="Pimavanserin">Pimavanserin</a></li> <li><a href="/wiki/Sertindole" title="Sertindole">Sertindole</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Monoamine-depleting_agent" title="Monoamine-depleting agent">Monoamine-depleting agents</a>: <a href="/wiki/Oxypertine" title="Oxypertine">Oxypertine</a></li> <li><a href="/wiki/Reserpine" title="Reserpine">Reserpine</a></li> <li><a href="/wiki/Tetrabenazine" title="Tetrabenazine">Tetrabenazine</a></li></ul> <ul><li><a href="/wiki/Muscarinic_agonist" title="Muscarinic agonist">Muscarinic agonists</a>: <a href="/wiki/Xanomeline/trospium_chloride" title="Xanomeline/trospium chloride">Xanomeline/trospium chloride</a></li></ul> <ul><li>Others/unknown: <a href="/wiki/Azacyclonol" title="Azacyclonol">Azacyclonol</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="padding: 0px;"><div><div class="hlist"> <ul><li>#<a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li>‡<a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li>†<a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li>§Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Dopamine_receptor_modulators745" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Dopamine_receptor_modulators" title="Template:Dopamine receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Dopamine_receptor_modulators" title="Template talk:Dopamine receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Dopamine_receptor_modulators" title="Special:EditPage/Template:Dopamine receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Dopamine_receptor_modulators745" style="font-size:114%;margin:0 4em"><a href="/wiki/Dopamine_receptor" title="Dopamine receptor">Dopamine receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/D1-like_receptor" title="D1-like receptor">D1-like</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Benzazepines: <a href="/wiki/6-Br-APB" title="6-Br-APB">6-Br-APB</a></li> <li><a href="/wiki/Fenoldopam" title="Fenoldopam">Fenoldopam</a></li> <li><a href="/wiki/SKF-38,393" title="SKF-38,393">SKF-38,393</a></li> <li><a href="/wiki/SKF-77,434" title="SKF-77,434">SKF-77,434</a></li> <li><a href="/wiki/SKF-81,297" title="SKF-81,297">SKF-81,297</a></li> <li><a href="/wiki/SKF-82,958" title="SKF-82,958">SKF-82,958</a></li> <li><a href="/wiki/SKF-83,959" title="SKF-83,959">SKF-83,959</a></li> <li><a href="/wiki/Trepipam" title="Trepipam">Trepipam</a></li> <li><a href="/wiki/Zelandopam" title="Zelandopam">Zelandopam</a></li></ul> <ul><li>Ergolines: <a href="/wiki/Cabergoline" title="Cabergoline">Cabergoline</a></li> <li><a href="/wiki/CY-208,243" title="CY-208,243">CY-208,243</a></li> <li><a href="/wiki/Dihydroergocryptine" title="Dihydroergocryptine">Dihydroergocryptine</a></li> <li><a href="/w/index.php?title=LEK-8829&action=edit&redlink=1" class="new" title="LEK-8829 (page does not exist)">LEK-8829</a></li> <li><a href="/wiki/Lisuride" title="Lisuride">Lisuride</a></li> <li><a href="/wiki/Pergolide" title="Pergolide">Pergolide</a></li> <li><a href="/wiki/Terguride" title="Terguride">Terguride</a></li></ul> <ul><li>Dihydrexidine derivatives: <a href="/wiki/A-77636" title="A-77636">A-77636</a></li> <li><a href="/wiki/A-86929" title="A-86929">A-86929</a></li> <li><a href="/wiki/Adrogolide" class="mw-redirect" title="Adrogolide">Adrogolide (ABT-431, DAS-431)</a></li> <li><a href="/wiki/Dihydrexidine" title="Dihydrexidine">Dihydrexidine</a></li> <li><a href="/wiki/Dinapsoline" title="Dinapsoline">Dinapsoline</a></li> <li><a href="/wiki/Dinoxyline" title="Dinoxyline">Dinoxyline</a></li> <li><a href="/wiki/Doxanthrine" title="Doxanthrine">Doxanthrine</a></li></ul> <ul><li>Phenethylamines: <a href="/w/index.php?title=BCO-001&action=edit&redlink=1" class="new" title="BCO-001 (page does not exist)">BCO-001</a></li> <li><a href="/wiki/Deoxyepinephrine" title="Deoxyepinephrine">Deoxyepinephrine (N-methyldopamine, epinine)</a></li> <li><a href="/wiki/Dopexamine" title="Dopexamine">Dopexamine</a></li> <li><a href="/wiki/Etilevodopa" title="Etilevodopa">Etilevodopa</a></li> <li><a href="/wiki/Ibopamine" title="Ibopamine">Ibopamine</a></li> <li><a href="/wiki/L-DOPA" title="L-DOPA">L-DOPA (levodopa)</a></li> <li><a href="/wiki/Melevodopa" title="Melevodopa">Melevodopa</a></li> <li><a href="/wiki/Phenylalanine" title="Phenylalanine">L-Phenylalanine</a></li> <li><a href="/wiki/Tyrosine" title="Tyrosine">L-Tyrosine</a></li> <li><a href="/wiki/XP21279" class="mw-redirect" title="XP21279">XP21279</a></li></ul> <ul><li>Others: <a href="/wiki/A-68930" title="A-68930">A-68930</a></li> <li><a href="/wiki/Apomorphine" title="Apomorphine">Apomorphine</a></li> <li><a href="/w/index.php?title=Isocorypalmine&action=edit&redlink=1" class="new" title="Isocorypalmine (page does not exist)">Isocorypalmine</a></li> <li><a href="/wiki/Nuciferine" title="Nuciferine">Nuciferine</a></li> <li><a href="/wiki/PF-6649751" class="mw-redirect" title="PF-6649751">PF-6649751</a></li> <li><a href="/w/index.php?title=PF_6669571&action=edit&redlink=1" class="new" title="PF 6669571 (page does not exist)">PF 6669571</a></li> <li><a href="/wiki/Propylnorapomorphine" title="Propylnorapomorphine">Propylnorapomorphine</a></li> <li><a href="/wiki/Rotigotine" title="Rotigotine">Rotigotine</a></li> <li><a href="/wiki/SKF-89,145" title="SKF-89,145">SKF-89,145</a></li> <li><a href="/w/index.php?title=SKF-89,626&action=edit&redlink=1" class="new" title="SKF-89,626 (page does not exist)">SKF-89,626</a></li> <li><a href="/wiki/Stepholidine" title="Stepholidine">Stepholidine</a></li> <li><a href="/wiki/Tavapadon" title="Tavapadon">Tavapadon</a></li> <li><a href="/wiki/Tetrahydropalmatine" title="Tetrahydropalmatine">Tetrahydropalmatine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><abbr title="Positive allosteric modulators">PAMs</abbr></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Tetrahydroisoquinolines: <a href="/w/index.php?title=DETQ&action=edit&redlink=1" class="new" title="DETQ (page does not exist)">DETQ</a></li> <li><a href="/w/index.php?title=DPTQ&action=edit&redlink=1" class="new" title="DPTQ (page does not exist)">DPTQ</a></li> <li><a href="/wiki/Mevidalen" title="Mevidalen">Mevidalen</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Typical antipsychotics: <a href="/wiki/Butaclamol" title="Butaclamol">Butaclamol</a></li> <li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Chlorprothixene" title="Chlorprothixene">Chlorprothixene</a></li> <li><a href="/wiki/Flupentixol" title="Flupentixol">Flupentixol (flupenthixol)</a> (<a href="/wiki/Flupentixol/melitracen" title="Flupentixol/melitracen">+melitracen</a>)</li> <li><a href="/wiki/Fluphenazine" title="Fluphenazine">Fluphenazine</a></li> <li><a href="/wiki/Loxapine" title="Loxapine">Loxapine</a></li> <li><a href="/wiki/Perphenazine" title="Perphenazine">Perphenazine</a> (<a href="/wiki/Amitriptyline/perphenazine" title="Amitriptyline/perphenazine">+amitriptyline</a>)</li> <li><a href="/w/index.php?title=Pifluthixol&action=edit&redlink=1" class="new" title="Pifluthixol (page does not exist)">Pifluthixol</a></li> <li><a href="/wiki/Thioridazine" title="Thioridazine">Thioridazine</a></li> <li><a href="/wiki/Thiothixene" class="mw-redirect" title="Thiothixene">Thiothixene</a></li> <li><a href="/wiki/Trifluoperazine" title="Trifluoperazine">Trifluoperazine</a> (<a href="/wiki/Tranylcypromine/trifluoperazine" title="Tranylcypromine/trifluoperazine">+tranylcypromine</a>)</li> <li><a href="/wiki/Zuclopenthixol" title="Zuclopenthixol">Zuclopenthixol</a></li></ul> <ul><li>Atypical antipsychotics: <a href="/wiki/Asenapine" title="Asenapine">Asenapine</a></li> <li><a href="/wiki/Clorotepine" title="Clorotepine">Clorotepine</a></li> <li><a href="/wiki/Clotiapine" title="Clotiapine">Clotiapine</a></li> <li><a href="/wiki/Clozapine" title="Clozapine">Clozapine</a></li> <li><a href="/wiki/DHA-clozapine" title="DHA-clozapine">DHA-clozapine</a></li> <li><a href="/wiki/Fluperlapine" title="Fluperlapine">Fluperlapine</a></li> <li><a href="/wiki/Iloperidone" title="Iloperidone">Iloperidone</a></li> <li><a href="/wiki/Norclozapine" class="mw-redirect" title="Norclozapine">Norclozapine</a></li> <li><a href="/w/index.php?title=Norquetiapine&action=edit&redlink=1" class="new" title="Norquetiapine (page does not exist)">Norquetiapine</a></li> <li><a href="/wiki/Olanzapine" title="Olanzapine">Olanzapine</a> (<a href="/wiki/Olanzapine/fluoxetine" title="Olanzapine/fluoxetine">+fluoxetine</a>)</li> <li><a href="/wiki/Paliperidone" title="Paliperidone">Paliperidone</a></li> <li><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a></li> <li><a href="/wiki/Risperidone" title="Risperidone">Risperidone</a></li> <li><a href="/w/index.php?title=Tefludazine&action=edit&redlink=1" class="new" title="Tefludazine (page does not exist)">Tefludazine</a></li> <li><a href="/wiki/Zicronapine" title="Zicronapine">Zicronapine</a></li> <li><a href="/wiki/Ziprasidone" title="Ziprasidone">Ziprasidone</a></li> <li><a href="/wiki/Zotepine" title="Zotepine">Zotepine</a></li></ul> <ul><li>Others: <a href="/wiki/Berupipam" title="Berupipam">Berupipam</a></li> <li><a href="/wiki/Ecopipam" title="Ecopipam">Ecopipam</a></li> <li><a href="/wiki/N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline" title="N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline">EEDQ</a></li> <li><a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/Odapipam" title="Odapipam">Odapipam</a></li> <li><a href="/wiki/Perlapine" title="Perlapine">Perlapine</a></li> <li><a href="/wiki/SCH-23390" title="SCH-23390">SCH-23390</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/D2-like_receptor" title="D2-like receptor">D2-like</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Agonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Adamantanes: <a href="/wiki/Amantadine" title="Amantadine">Amantadine</a></li> <li><a href="/wiki/Memantine" title="Memantine">Memantine</a></li> <li><a href="/wiki/Rimantadine" title="Rimantadine">Rimantadine</a></li></ul> <ul><li>Aminotetralins: <a href="/wiki/5-OH-DPAT" title="5-OH-DPAT">5-OH-DPAT</a></li> <li><a href="/wiki/7-OH-DPAT" title="7-OH-DPAT">7-OH-DPAT</a></li> <li><a href="/wiki/8-OH-PBZI" title="8-OH-PBZI">8-OH-PBZI</a></li> <li><a href="/wiki/Rotigotine" title="Rotigotine">Rotigotine</a></li> <li><a href="/wiki/UH-232" title="UH-232">UH-232</a></li></ul> <ul><li>Ergolines: <a href="/wiki/Bromocriptine" title="Bromocriptine">Bromocriptine</a></li> <li><a href="/wiki/Cabergoline" title="Cabergoline">Cabergoline</a></li> <li><a href="/wiki/Chanoclavine" title="Chanoclavine">Chanoclavine</a></li> <li><a href="/wiki/Dihydroergocryptine" title="Dihydroergocryptine">Dihydroergocryptine</a></li> <li><a href="/wiki/Epicriptine" title="Epicriptine">Epicriptine</a></li> <li><a href="/wiki/Ergocornine" title="Ergocornine">Ergocornine</a></li> <li><a href="/wiki/Lergotrile" title="Lergotrile">Lergotrile</a></li> <li><a href="/wiki/Lisuride" title="Lisuride">Lisuride</a></li> <li><a href="/wiki/LSD" title="LSD">LSD</a></li> <li><a href="/wiki/Pergolide" title="Pergolide">Pergolide</a></li> <li><a href="/wiki/Terguride" title="Terguride">Terguride</a></li></ul> <ul><li>Dihydrexidine derivatives: <a href="/wiki/2-OH-NPA" title="2-OH-NPA">2-OH-NPA</a></li> <li><a href="/wiki/Ciladopa" title="Ciladopa">Ciladopa</a></li> <li><a href="/wiki/Dihydrexidine" title="Dihydrexidine">Dihydrexidine</a></li> <li><a href="/wiki/Dinoxyline" title="Dinoxyline">Dinoxyline</a></li> <li><a href="/w/index.php?title=N,N-Propyldihydrexidine&action=edit&redlink=1" class="new" title="N,N-Propyldihydrexidine (page does not exist)">N,N-Propyldihydrexidine</a></li></ul> <ul><li>Phenethylamines: <a href="/wiki/Deoxyepinephrine" title="Deoxyepinephrine">Deoxyepinephrine (N-methyldopamine, epinine)</a></li> <li><a href="/wiki/Dopexamine" title="Dopexamine">Dopexamine</a></li> <li><a href="/wiki/Etilevodopa" title="Etilevodopa">Etilevodopa</a></li> <li><a href="/wiki/Ibopamine" title="Ibopamine">Ibopamine</a></li> <li><a href="/wiki/L-DOPA" title="L-DOPA">L-DOPA (levodopa)</a></li> <li><a href="/wiki/Phenylalanine" title="Phenylalanine">L-Phenylalanine</a></li> <li><a href="/wiki/Tyrosine" title="Tyrosine">L-Tyrosine</a></li> <li><a href="/wiki/Melevodopa" title="Melevodopa">Melevodopa</a></li> <li><a href="/wiki/XP21279" class="mw-redirect" title="XP21279">XP21279</a></li></ul> <ul><li>Atypical antipsychotics: <a href="/wiki/Alentemol" title="Alentemol">Alentemol (U-66444B)</a></li> <li><a href="/wiki/Aripiprazole" title="Aripiprazole">Aripiprazole</a> (<a href="/wiki/Aripiprazole/sertraline" title="Aripiprazole/sertraline">+sertraline</a>)</li> <li><a href="/wiki/Aripiprazole_lauroxil" title="Aripiprazole lauroxil">Aripiprazole lauroxil</a></li> <li><a href="/wiki/Bifeprunox" title="Bifeprunox">Bifeprunox</a></li> <li><a href="/wiki/Brexpiprazole" title="Brexpiprazole">Brexpiprazole</a></li> <li><a href="/wiki/Brilaroxazine" title="Brilaroxazine">Brilaroxazine</a></li> <li><a href="/wiki/Cariprazine" title="Cariprazine">Cariprazine</a></li> <li><a href="/wiki/F-15063" title="F-15063">F-15063</a></li> <li><a href="/wiki/Lumateperone" title="Lumateperone">Lumateperone</a></li> <li><a href="/wiki/Norclozapine" class="mw-redirect" title="Norclozapine">Norclozapine</a></li></ul> <ul><li>Others: <a href="/wiki/3-PPP" title="3-PPP">3-PPP</a></li> <li><a href="/wiki/A-412997" title="A-412997">A-412997</a></li> <li><a href="/wiki/ABT-670" title="ABT-670">ABT-670</a></li> <li><a href="/wiki/ABT-724" title="ABT-724">ABT-724</a></li> <li><a href="/wiki/Adrafinil" title="Adrafinil">Adrafinil</a></li> <li><a href="/wiki/Aplindore" title="Aplindore">Aplindore</a></li> <li><a href="/wiki/Apomorphine" title="Apomorphine">Apomorphine</a></li> <li><a href="/wiki/Arketamine" title="Arketamine">Arketamine</a></li> <li><a href="/wiki/Armodafinil" title="Armodafinil">Armodafinil</a></li> <li><a href="/wiki/BP-897" title="BP-897">BP-897</a></li> <li><a href="/wiki/Captodiame" title="Captodiame">Captodiame</a></li> <li><a href="/wiki/CP-226,269" title="CP-226,269">CP-226,269</a></li> <li><a href="/wiki/Dizocilpine" title="Dizocilpine">Dizocilpine</a></li> <li><a href="/wiki/Esketamine" title="Esketamine">Esketamine</a></li> <li><a href="/wiki/Flibanserin" title="Flibanserin">Flibanserin</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Mesulergine" title="Mesulergine">Mesulergine</a></li> <li><a href="/wiki/Modafinil" title="Modafinil">Modafinil</a></li> <li><a href="/wiki/Naxagolide" title="Naxagolide">Naxagolide</a></li> <li><a href="/wiki/OSU-6162" title="OSU-6162">OSU-6162</a></li> <li><a href="/wiki/Pardoprunox" title="Pardoprunox">Pardoprunox</a></li> <li><a href="/wiki/PD-128,907" title="PD-128,907">PD-128,907</a></li> <li><a href="/wiki/PD-168,077" title="PD-168,077">PD-168,077</a></li> <li><a href="/wiki/PF-219,061" title="PF-219,061">PF-219,061</a></li> <li><a href="/wiki/PF-592,379" title="PF-592,379">PF-592,379</a></li> <li><a href="/wiki/Phencyclidine" title="Phencyclidine">Phencyclidine</a></li> <li><a href="/wiki/Piribedil" title="Piribedil">Piribedil</a></li> <li><a href="/wiki/Pramipexole" title="Pramipexole">Pramipexole</a></li> <li><a href="/wiki/Preclamol" class="mw-redirect" title="Preclamol">Preclamol</a></li> <li><a href="/wiki/Propylnorapomorphine" title="Propylnorapomorphine">Propylnorapomorphine</a></li> <li><a href="/wiki/Pukateine" title="Pukateine">Pukateine</a></li> <li><a href="/wiki/Quinagolide" title="Quinagolide">Quinagolide</a></li> <li><a href="/wiki/Quinelorane" title="Quinelorane">Quinelorane</a></li> <li><a href="/wiki/Quinpirole" title="Quinpirole">Quinpirole</a></li> <li><a href="/wiki/RDS-127" title="RDS-127">RDS-127</a></li> <li><a href="/wiki/Ro10-5824" title="Ro10-5824">Ro10-5824</a></li> <li><a href="/wiki/Ropinirole" title="Ropinirole">Ropinirole</a></li> <li><a href="/wiki/Roxindole" title="Roxindole">Roxindole</a></li> <li><a href="/wiki/Salvinorin_A" title="Salvinorin A">Salvinorin A</a></li> <li><a href="/wiki/SKF-83,959" title="SKF-83,959">SKF-83,959</a></li> <li><a href="/wiki/Sumanirole" title="Sumanirole">Sumanirole</a></li> <li><a href="/wiki/Talipexole" title="Talipexole">Talipexole</a></li> <li><a href="/wiki/Umespirone" title="Umespirone">Umespirone</a></li> <li><a href="/wiki/WAY-100,635" class="mw-redirect" title="WAY-100,635">WAY-100,635</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Typical antipsychotics: <a href="/wiki/Acepromazine" title="Acepromazine">Acepromazine</a></li> <li><a href="/wiki/Acetophenazine" title="Acetophenazine">Acetophenazine</a></li> <li><a href="/wiki/Azaperone" title="Azaperone">Azaperone</a></li> <li><a href="/wiki/Benperidol" title="Benperidol">Benperidol</a></li> <li><a href="/wiki/Bromperidol" title="Bromperidol">Bromperidol</a></li> <li><a href="/wiki/Butaclamol" title="Butaclamol">Butaclamol</a></li> <li><a href="/wiki/Butaperazine" title="Butaperazine">Butaperazine</a></li> <li><a href="/wiki/Chloracizine" class="mw-redirect" title="Chloracizine">Chloracizine</a></li> <li><a href="/wiki/Chlorproethazine" title="Chlorproethazine">Chlorproethazine</a></li> <li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Chlorprothixene" title="Chlorprothixene">Chlorprothixene</a></li> <li><a href="/wiki/Ciclindole" title="Ciclindole">Ciclindole</a></li> <li><a href="/wiki/Clopenthixol" title="Clopenthixol">Clopenthixol</a></li> <li><a href="/w/index.php?title=Clothixamide&action=edit&redlink=1" class="new" title="Clothixamide (page does not exist)">Clothixamide</a></li> <li><a href="/wiki/Clopimozide" title="Clopimozide">Clopimozide</a></li> <li><a href="/wiki/Droperidol" title="Droperidol">Droperidol</a></li> <li><a href="/wiki/Fluacizine" title="Fluacizine">Fluacizine</a></li> <li><a href="/wiki/Fluanisone" title="Fluanisone">Fluanisone</a></li> <li><a href="/wiki/Flucindole" title="Flucindole">Flucindole</a></li> <li><a href="/wiki/Fluotracen" title="Fluotracen">Fluotracen</a></li> <li><a href="/wiki/Flupentixol" title="Flupentixol">Flupentixol (flupenthixol)</a> (<a href="/wiki/Flupentixol/melitracen" title="Flupentixol/melitracen">+melitracen</a>)</li> <li><a href="/wiki/Fluphenazine" title="Fluphenazine">Fluphenazine</a></li> <li><a href="/w/index.php?title=Fluprothixene&action=edit&redlink=1" class="new" title="Fluprothixene (page does not exist)">Fluprothixene</a></li> <li><a href="/wiki/Fluspirilene" title="Fluspirilene">Fluspirilene</a></li> <li><a href="/wiki/Haloperidol" title="Haloperidol">Haloperidol</a></li> <li><a href="/wiki/Homopipramol" title="Homopipramol">Homopipramol</a></li> <li><a href="/wiki/Lenperone" title="Lenperone">Lenperone</a></li> <li><a href="/wiki/Levomepromazine" title="Levomepromazine">Levomepromazine (methotrimeprazine)</a></li> <li><a href="/wiki/Levosulpiride" title="Levosulpiride">Levosulpiride</a></li> <li><a href="/wiki/Loxapine" title="Loxapine">Loxapine</a></li> <li><a href="/wiki/Mesoridazine" title="Mesoridazine">Mesoridazine</a></li> <li><a href="/wiki/Moperone" title="Moperone">Moperone</a></li> <li><a href="/wiki/Naranol" title="Naranol">Naranol</a></li> <li><a href="/wiki/Nemonapride" title="Nemonapride">Nemonapride</a></li> <li><a href="/wiki/Penfluridol" title="Penfluridol">Penfluridol</a></li> <li><a href="/wiki/Perathiepin" title="Perathiepin">Perathiepin</a></li> <li><a href="/wiki/Perazine" title="Perazine">Perazine</a></li> <li><a href="/wiki/Periciazine" title="Periciazine">Pericyazine (periciazine)</a></li> <li><a href="/wiki/Perphenazine" title="Perphenazine">Perphenazine</a> (<a href="/wiki/Amitriptyline/perphenazine" title="Amitriptyline/perphenazine">+amitriptyline</a>)</li> <li><a href="/w/index.php?title=Piflutixol&action=edit&redlink=1" class="new" title="Piflutixol (page does not exist)">Piflutixol (pifluthixol)</a></li> <li><a href="/wiki/Pimozide" title="Pimozide">Pimozide</a></li> <li><a href="/wiki/Pipamperone" title="Pipamperone">Pipamperone</a></li> <li><a href="/wiki/Preclamol" class="mw-redirect" title="Preclamol">Preclamol</a></li> <li><a href="/wiki/Prochlorperazine" title="Prochlorperazine">Prochlorperazine</a></li> <li><a href="/wiki/Promazine" title="Promazine">Promazine</a></li> <li><a href="/wiki/Prothipendyl" title="Prothipendyl">Prothipendyl</a></li> <li><a href="/wiki/Spiperone" title="Spiperone">Spiperone (spiroperidol)</a></li> <li><a href="/wiki/Sulforidazine" title="Sulforidazine">Sulforidazine</a></li> <li><a href="/wiki/Sulpiride" title="Sulpiride">Sulpiride</a></li> <li><a href="/wiki/Sultopride" title="Sultopride">Sultopride</a></li> <li><a href="/w/index.php?title=Teflutixol&action=edit&redlink=1" class="new" title="Teflutixol (page does not exist)">Teflutixol</a></li> <li><a href="/wiki/Thiopropazate" title="Thiopropazate">Thiopropazate</a></li> <li><a href="/wiki/Thioproperazine" title="Thioproperazine">Thioproperazine</a></li> <li><a href="/wiki/Thioridazine" title="Thioridazine">Thioridazine</a></li> <li><a href="/wiki/Thiothixene" class="mw-redirect" title="Thiothixene">Thiothixene</a></li> <li><a href="/wiki/Timiperone" title="Timiperone">Timiperone</a></li> <li><a href="/wiki/Trifluoperazine" title="Trifluoperazine">Trifluoperazine</a> (<a href="/wiki/Tranylcypromine/trifluoperazine" title="Tranylcypromine/trifluoperazine">+tranylcypromine</a>)</li> <li><a href="/wiki/Triflupromazine" title="Triflupromazine">Triflupromazine</a></li> <li><a href="/wiki/Trifluperidol" title="Trifluperidol">Trifluperidol</a></li> <li><a href="/w/index.php?title=Zetidoline&action=edit&redlink=1" class="new" title="Zetidoline (page does not exist)">Zetidoline</a></li> <li><a href="/wiki/Zuclopenthixol" title="Zuclopenthixol">Zuclopenthixol</a></li></ul> <ul><li>Atypical antipsychotics: <a href="/wiki/Amisulpride" title="Amisulpride">Amisulpride</a></li> <li><a href="/wiki/Asenapine" title="Asenapine">Asenapine</a></li> <li><a href="/wiki/BL-1020" title="BL-1020">BL-1020</a></li> <li><a href="/wiki/Blonanserin" title="Blonanserin">Blonanserin</a></li> <li><a href="/wiki/Carpipramine" title="Carpipramine">Carpipramine</a></li> <li><a href="/w/index.php?title=Cinuperone&action=edit&redlink=1" class="new" title="Cinuperone (page does not exist)">Cinuperone</a></li> <li><a href="/wiki/Clocapramine" title="Clocapramine">Clocapramine</a></li> <li><a href="/wiki/Clorotepine" title="Clorotepine">Clorotepine</a></li> <li><a href="/wiki/Clotiapine" title="Clotiapine">Clotiapine (clothiapine)</a></li> <li><a href="/wiki/Clozapine" title="Clozapine">Clozapine</a></li> <li><a href="/wiki/Cyamemazine" title="Cyamemazine">Cyamemazine</a></li> <li><a href="/wiki/DHA-clozapine" title="DHA-clozapine">DHA-clozapine</a></li> <li><a href="/wiki/Dixyrazine" title="Dixyrazine">Dixyrazine</a></li> <li><a href="/wiki/Elopiprazole" title="Elopiprazole">Elopiprazole</a></li> <li><a href="/wiki/Flumezapine" title="Flumezapine">Flumezapine</a></li> <li><a href="/wiki/Fluperlapine" title="Fluperlapine">Fluperlapine</a></li> <li><a href="/wiki/Gevotroline" title="Gevotroline">Gevotroline</a></li> <li><a href="/wiki/Iloperidone" title="Iloperidone">Iloperidone</a></li> <li><a href="/wiki/Lurasidone" title="Lurasidone">Lurasidone</a></li> <li><a href="/wiki/Mazapertine" title="Mazapertine">Mazapertine</a></li> <li><a href="/wiki/Melperone" title="Melperone">Melperone</a></li> <li><a href="/wiki/Molindone" title="Molindone">Molindone</a></li> <li><a href="/wiki/Mosapramine" title="Mosapramine">Mosapramine</a></li> <li><a href="/wiki/Ocaperidone" title="Ocaperidone">Ocaperidone</a></li> <li><a href="/wiki/Olanzapine" title="Olanzapine">Olanzapine</a> (<a href="/wiki/Olanzapine/fluoxetine" title="Olanzapine/fluoxetine">+fluoxetine</a>)</li> <li><a href="/wiki/Paliperidone" title="Paliperidone">Paliperidone</a></li> <li><a href="/wiki/Perospirone" title="Perospirone">Perospirone</a></li> <li><a href="/wiki/Piperacetazine" title="Piperacetazine">Piperacetazine</a></li> <li><a href="/wiki/Pipotiazine" title="Pipotiazine">Pipotiazine</a></li> <li><a href="/wiki/Piquindone" title="Piquindone">Piquindone</a></li> <li><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a></li> <li><a href="/wiki/Remoxipride" title="Remoxipride">Remoxipride</a></li> <li><a href="/wiki/Risperidone" title="Risperidone">Risperidone</a></li> <li><a href="/wiki/Sertindole" title="Sertindole">Sertindole</a></li> <li><a href="/w/index.php?title=Tefludazine&action=edit&redlink=1" class="new" title="Tefludazine (page does not exist)">Tefludazine</a></li> <li><a href="/wiki/Tenilapine" title="Tenilapine">Tenilapine</a></li> <li><a href="/wiki/Tiospirone" title="Tiospirone">Tiospirone</a></li> <li><a href="/wiki/Veralipride" title="Veralipride">Veralipride</a></li> <li><a href="/wiki/Zicronapine" title="Zicronapine">Zicronapine</a></li> <li><a href="/wiki/Ziprasidone" title="Ziprasidone">Ziprasidone</a></li> <li><a href="/wiki/Zotepine" title="Zotepine">Zotepine</a></li></ul> <ul><li>Antiemetics/gastroprokinetics/sedatives: <a href="/wiki/Aceprometazine" title="Aceprometazine">Aceprometazine</a></li> <li><a href="/wiki/AS-8112" title="AS-8112">AS-8112</a></li> <li><a href="/wiki/Alimemazine" title="Alimemazine">Alimemazine</a></li> <li><a href="/wiki/Alizapride" title="Alizapride">Alizapride</a></li> <li><a href="/wiki/Benzquinamide" title="Benzquinamide">Benzquinamide</a></li> <li><a href="/wiki/Bromopride" title="Bromopride">Bromopride</a></li> <li><a href="/wiki/Clebopride" title="Clebopride">Clebopride</a></li> <li><a href="/wiki/Deudomperidone" title="Deudomperidone">Deudomperidone</a></li> <li><a href="/wiki/Domperidone" title="Domperidone">Domperidone</a></li> <li><a href="/wiki/Eticlopride" title="Eticlopride">Eticlopride</a></li> <li><a href="/wiki/Hydroxyzine" title="Hydroxyzine">Hydroxyzine</a></li> <li><a href="/wiki/Itopride" title="Itopride">Itopride</a></li> <li><a href="/wiki/Metoclopramide" title="Metoclopramide">Metoclopramide</a></li> <li><a href="/wiki/Metopimazine" title="Metopimazine">Metopimazine</a></li> <li><a href="/wiki/Promethazine" title="Promethazine">Promethazine</a></li> <li><a href="/wiki/Thiethylperazine" title="Thiethylperazine">Thiethylperazine</a></li> <li><a href="/wiki/Trazpiroben" title="Trazpiroben">Trazpiroben</a></li> <li><a href="/wiki/Trimethobenzamide" title="Trimethobenzamide">Trimethobenzamide</a></li></ul> <ul><li>Antidepressants: <a href="/wiki/Amoxapine" title="Amoxapine">Amoxapine</a></li> <li><a href="/wiki/Nefazodone" title="Nefazodone">Nefazodone</a></li> <li><a href="/wiki/Opipramol" title="Opipramol">Opipramol</a></li> <li><a href="/wiki/Propiomazine" title="Propiomazine">Propiomazine</a></li> <li><a href="/wiki/Trimipramine" title="Trimipramine">Trimipramine</a></li></ul> <ul><li>Others: <a href="/wiki/3-PPP" title="3-PPP">3-PPP</a></li> <li><a href="/wiki/Alpiropride" title="Alpiropride">Alpiropride</a></li> <li><a href="/wiki/Azapride" title="Azapride">Azapride</a></li> <li><a href="/wiki/Bromerguride" title="Bromerguride">Bromerguride</a></li> <li><a href="/wiki/Bromocriptine" title="Bromocriptine">Bromocriptine</a></li> <li><a href="/wiki/Buspirone" title="Buspirone">Buspirone</a></li> <li><a href="/wiki/Desmethoxyfallypride" title="Desmethoxyfallypride">Desmethoxyfallypride</a></li> <li><a href="/wiki/N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline" title="N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline">EEDQ</a></li> <li><a href="/wiki/F-15063" title="F-15063">F-15063</a></li> <li><a href="/wiki/Fallypride" title="Fallypride">Fallypride</a></li> <li><a href="/wiki/Fananserin" title="Fananserin">Fananserin</a></li> <li><a href="/wiki/Fenfluramine" title="Fenfluramine">Fenfluramine</a></li> <li><a href="/wiki/Iodobenzamide" title="Iodobenzamide">Iodobenzamide</a></li> <li><a href="/w/index.php?title=Isocorypalmine&action=edit&redlink=1" class="new" title="Isocorypalmine (page does not exist)">Isocorypalmine</a></li> <li><a href="/wiki/L-741,626" title="L-741,626">L-741,626</a></li> <li><a href="/wiki/L-745,870" title="L-745,870">L-745,870</a></li> <li><a href="/wiki/Levofenfluramine" title="Levofenfluramine">Levofenfluramine</a></li> <li><a href="/w/index.php?title=LEK-8829&action=edit&redlink=1" class="new" title="LEK-8829 (page does not exist)">LEK-8829</a></li> <li><a href="/wiki/Metergoline" title="Metergoline">Metergoline</a></li> <li><a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/N-Methylspiperone" title="N-Methylspiperone">N-Methylspiperone</a></li> <li><a href="/wiki/Nafadotride" title="Nafadotride">Nafadotride</a></li> <li><a href="/wiki/Nuciferine" title="Nuciferine">Nuciferine</a></li> <li><a href="/wiki/PNU-99,194" title="PNU-99,194">PNU-99,194</a></li> <li><a href="/wiki/Pridopidine" title="Pridopidine">Pridopidine</a></li> <li><a href="/wiki/Raclopride" title="Raclopride">Raclopride</a></li> <li><a href="/wiki/Sarizotan" title="Sarizotan">Sarizotan</a></li> <li><a href="/wiki/SB-277,011-A" title="SB-277,011-A">SB-277,011-A</a></li> <li><a href="/w/index.php?title=Seridopidine&action=edit&redlink=1" class="new" title="Seridopidine (page does not exist)">Seridopidine</a></li> <li><a href="/wiki/Sonepiprazole" title="Sonepiprazole">Sonepiprazole</a></li> <li><a href="/wiki/Spiroxatrine" title="Spiroxatrine">Spiroxatrine</a></li> <li><a href="/wiki/Stepholidine" title="Stepholidine">Stepholidine</a></li> <li><a href="/w/index.php?title=SV-293&action=edit&redlink=1" class="new" title="SV-293 (page does not exist)">SV-293</a></li> <li><a href="/wiki/Terguride" title="Terguride">Terguride</a></li> <li><a href="/wiki/Tetrahydropalmatine" title="Tetrahydropalmatine">Tetrahydropalmatine</a></li> <li><a href="/wiki/Tiapride" title="Tiapride">Tiapride</a></li> <li><a href="/wiki/UH-232" title="UH-232">UH-232</a></li> <li><a href="/wiki/Yohimbine" title="Yohimbine">Yohimbine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li>See also: <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></li> <li><a href="/wiki/Template:Adrenergic_receptor_modulators" title="Template:Adrenergic receptor modulators">Adrenergics</a></li> <li><a href="/wiki/Template:Serotonin_receptor_modulators" title="Template:Serotonin receptor modulators">Serotonergics</a></li> <li><a href="/wiki/Template:Monoamine_reuptake_inhibitors" title="Template:Monoamine reuptake inhibitors">Monoamine reuptake inhibitors</a></li> <li><a href="/wiki/Template:Monoamine_releasing_agents" title="Template:Monoamine releasing agents">Monoamine releasing agents</a></li> <li><a href="/wiki/Template:Monoamine_metabolism_modulators" title="Template:Monoamine metabolism modulators">Monoamine metabolism modulators</a></li> <li><a href="/wiki/Template:Monoamine_neurotoxins" class="mw-redirect" title="Template:Monoamine neurotoxins">Monoamine neurotoxins</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Serotonin_receptor_modulators871" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Serotonin_receptor_modulators" title="Template:Serotonin receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Serotonin_receptor_modulators" title="Template talk:Serotonin receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Serotonin_receptor_modulators" title="Special:EditPage/Template:Serotonin receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Serotonin_receptor_modulators871" style="font-size:114%;margin:0 4em"><a href="/wiki/5-HT_receptor" title="5-HT receptor">Serotonin receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT1_receptor" title="5-HT1 receptor">5-HT1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">5-HT1A</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/8-OH-DPAT" title="8-OH-DPAT">8-OH-DPAT</a></li> <li><a href="/wiki/Adatanserin" title="Adatanserin">Adatanserin</a></li> <li><a href="/wiki/Amphetamine" title="Amphetamine">Amphetamine</a></li> <li><a href="/wiki/Antidepressant" title="Antidepressant">Antidepressants</a> (e.g., <a href="/wiki/Etoperidone" title="Etoperidone">etoperidone</a>, <a href="/wiki/Hydroxynefazodone" title="Hydroxynefazodone">hydroxynefazodone</a>, <a href="/wiki/Nefazodone" title="Nefazodone">nefazodone</a>, <a href="/wiki/Trazodone" title="Trazodone">trazodone</a>, <a href="/wiki/Triazoledione" title="Triazoledione">triazoledione</a>, <a href="/wiki/Vilazodone" title="Vilazodone">vilazodone</a>, <a href="/wiki/Vortioxetine" title="Vortioxetine">vortioxetine</a>)</li> <li><a class="mw-selflink selflink">Atypical antipsychotics</a> (e.g., <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="/wiki/Asenapine" title="Asenapine">asenapine</a>, <a href="/wiki/Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>, <a href="/wiki/Cariprazine" title="Cariprazine">cariprazine</a>, <a href="/wiki/Clozapine" title="Clozapine">clozapine</a>, <a href="/wiki/Lurasidone" title="Lurasidone">lurasidone</a>, <a href="/wiki/Quetiapine" title="Quetiapine">quetiapine</a>, <a href="/wiki/Ziprasidone" title="Ziprasidone">ziprasidone</a>)</li> <li><a href="/wiki/Azapirone" title="Azapirone">Azapirones</a> (e.g., <a href="/wiki/Buspirone" title="Buspirone">buspirone</a>, <a href="/wiki/Eptapirone" title="Eptapirone">eptapirone</a>, <a href="/wiki/Gepirone" title="Gepirone">gepirone</a>, <a href="/wiki/Perospirone" title="Perospirone">perospirone</a>, <a href="/wiki/Tandospirone" title="Tandospirone">tandospirone</a>)</li> <li><a href="/wiki/Bay_R_1531" title="Bay R 1531">Bay R 1531</a></li> <li><a href="/wiki/Befiradol" title="Befiradol">Befiradol</a></li> <li><a href="/wiki/BMY-14802" title="BMY-14802">BMY-14802</a></li> <li><a href="/wiki/Cannabidiol" title="Cannabidiol">Cannabidiol</a></li> <li><a href="/wiki/Dimemebfe" title="Dimemebfe">Dimemebfe</a></li> <li><a href="/wiki/Dopamine" title="Dopamine">Dopamine</a></li> <li><a href="/wiki/Ebalzotan" title="Ebalzotan">Ebalzotan</a></li> <li><a href="/wiki/Eltoprazine" title="Eltoprazine">Eltoprazine</a></li> <li><a href="/wiki/Enciprazine" title="Enciprazine">Enciprazine</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="/wiki/Cabergoline" title="Cabergoline">cabergoline</a>, <a href="/wiki/Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="/wiki/Ergotamine" title="Ergotamine">ergotamine</a>, <a href="/wiki/Lisuride" title="Lisuride">lisuride</a>, <a href="/wiki/LSD" title="LSD">LSD</a>, <a href="/wiki/Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a>, <a href="/wiki/Methysergide" title="Methysergide">methysergide</a>, <a href="/wiki/Pergolide" title="Pergolide">pergolide</a>)</li> <li><a href="/wiki/F-11,461" title="F-11,461">F-11,461</a></li> <li><a href="/w/index.php?title=F-12826&action=edit&redlink=1" class="new" title="F-12826 (page does not exist)">F-12826</a></li> <li><a href="/w/index.php?title=F-13714&action=edit&redlink=1" class="new" title="F-13714 (page does not exist)">F-13714</a></li> <li><a href="/w/index.php?title=F-14679&action=edit&redlink=1" class="new" title="F-14679 (page does not exist)">F-14679</a></li> <li><a href="/wiki/F-15063" title="F-15063">F-15063</a></li> <li><a href="/wiki/F-15,599" title="F-15,599">F-15,599</a></li> <li><a href="/wiki/Flesinoxan" title="Flesinoxan">Flesinoxan</a></li> <li><a href="/wiki/Flibanserin" title="Flibanserin">Flibanserin</a></li> <li><a href="/wiki/Flumexadol" title="Flumexadol">Flumexadol</a></li> <li><a href="/wiki/Hypidone" title="Hypidone">Hypidone</a></li> <li><a href="/wiki/Lesopitron" title="Lesopitron">Lesopitron</a></li> <li><a href="/wiki/LY-293284" title="LY-293284">LY-293284</a></li> <li><a href="/w/index.php?title=LY-301317&action=edit&redlink=1" class="new" title="LY-301317 (page does not exist)">LY-301317</a></li> <li><a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li> <li><a href="/wiki/Osemozotan" title="Osemozotan">MKC-242</a></li> <li><a href="/wiki/Naluzotan" title="Naluzotan">Naluzotan</a></li> <li><a href="/wiki/NBUMP" title="NBUMP">NBUMP</a></li> <li><a href="/wiki/Osemozotan" title="Osemozotan">Osemozotan</a></li> <li><a href="/wiki/Oxaflozane" title="Oxaflozane">Oxaflozane</a></li> <li><a href="/wiki/Pardoprunox" title="Pardoprunox">Pardoprunox</a></li> <li><a href="/wiki/Piclozotan" title="Piclozotan">Piclozotan</a></li> <li><a href="/wiki/Rauwolscine" title="Rauwolscine">Rauwolscine</a></li> <li><a href="/wiki/Repinotan" title="Repinotan">Repinotan</a></li> <li><a href="/wiki/Roxindole" title="Roxindole">Roxindole</a></li> <li><a href="/wiki/RU-24,969" title="RU-24,969">RU-24,969</a></li> <li><a href="/wiki/S-14,506" title="S-14,506">S-14,506</a></li> <li><a href="/wiki/S-14671" title="S-14671">S-14671</a></li> <li><a href="/wiki/S-15535" title="S-15535">S-15535</a></li> <li><a href="/wiki/Sarizotan" title="Sarizotan">Sarizotan</a></li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/w/index.php?title=SSR-181507&action=edit&redlink=1" class="new" title="SSR-181507 (page does not exist)">SSR-181507</a></li> <li><a href="/wiki/Sunepitron" title="Sunepitron">Sunepitron</a></li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="/wiki/5-MeO-DMT" title="5-MeO-DMT">5-MeO-DMT</a>, <a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="/wiki/Bufotenin" title="Bufotenin">bufotenin</a>, <a href="/wiki/N,N-Dimethyltryptamine" title="N,N-Dimethyltryptamine">DMT</a>, <a href="/wiki/Indorenate" title="Indorenate">indorenate</a>, <a href="/wiki/N-Methylserotonin" title="N-Methylserotonin">N-Me-5-HT</a>, <a href="/wiki/Psilocin" title="Psilocin">psilocin</a>, <a href="/wiki/Psilocybin" title="Psilocybin">psilocybin</a>)</li> <li><a href="/wiki/TGBA01AD" title="TGBA01AD">TGBA01AD</a></li> <li><a href="/wiki/U-92,016-A" title="U-92,016-A">U-92,016-A</a></li> <li><a href="/wiki/Urapidil" title="Urapidil">Urapidil</a></li> <li><a href="/wiki/Vilazodone" title="Vilazodone">Vilazodone</a></li> <li><a href="/wiki/Xaliproden" title="Xaliproden">Xaliproden</a></li> <li><a href="/wiki/Yohimbine" title="Yohimbine">Yohimbine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a class="mw-selflink selflink">Atypical antipsychotics</a> (e.g., <a href="/wiki/Iloperidone" title="Iloperidone">iloperidone</a>, <a href="/wiki/Risperidone" title="Risperidone">risperidone</a>, <a href="/wiki/Sertindole" title="Sertindole">sertindole</a>)</li> <li><a href="/w/index.php?title=AV965&action=edit&redlink=1" class="new" title="AV965 (page does not exist)">AV965</a></li> <li><a href="/wiki/Beta_blocker" title="Beta blocker">Beta blockers</a> (e.g., <a href="/wiki/Alprenolol" title="Alprenolol">alprenolol</a>, <a href="/wiki/Carteolol" title="Carteolol">carteolol</a>, <a href="/wiki/Cyanopindolol" title="Cyanopindolol">cyanopindolol</a>, <a href="/wiki/Iodocyanopindolol" title="Iodocyanopindolol">iodocyanopindolol</a>, <a href="/wiki/Isamoltane" title="Isamoltane">isamoltane</a>, <a href="/wiki/Oxprenolol" title="Oxprenolol">oxprenolol</a>, <a href="/wiki/Penbutolol" title="Penbutolol">penbutolol</a>, <a href="/wiki/Pindobind" title="Pindobind">pindobind</a>, <a href="/wiki/Pindolol" title="Pindolol">pindolol</a>, <a href="/wiki/Propranolol" title="Propranolol">propranolol</a>, <a href="/wiki/Tertatolol" title="Tertatolol">tertatolol</a>)</li> <li><a href="/wiki/BMY-7,378" class="mw-redirect" title="BMY-7,378">BMY-7,378</a></li> <li><a href="/wiki/CSP-2503" title="CSP-2503">CSP-2503</a></li> <li><a href="/wiki/Dotarizine" title="Dotarizine">Dotarizine</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Metergoline" title="Metergoline">metergoline</a>)</li> <li><a href="/w/index.php?title=FCE-24379&action=edit&redlink=1" class="new" title="FCE-24379 (page does not exist)">FCE-24379</a></li> <li><a href="/wiki/Flopropione" title="Flopropione">Flopropione</a></li> <li><a href="/w/index.php?title=GR-46611&action=edit&redlink=1" class="new" title="GR-46611 (page does not exist)">GR-46611</a></li> <li><a href="/wiki/Isamoltane" title="Isamoltane">Isamoltane</a></li> <li><a href="/wiki/Lecozotan" title="Lecozotan">Lecozotan</a></li> <li><a href="/wiki/Mefway_(18F)" title="Mefway (18F)">Mefway</a></li> <li><a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/MIN-117" title="MIN-117">MIN-117 (WF-516)</a></li> <li><a href="/wiki/MPPF" title="MPPF">MPPF</a></li> <li><a href="/wiki/NAN-190" title="NAN-190">NAN-190</a></li> <li><a href="/wiki/Robalzotan" title="Robalzotan">Robalzotan</a></li> <li><a href="/wiki/S-15535" title="S-15535">S-15535</a></li> <li><a href="/wiki/SB-649,915" title="SB-649,915">SB-649,915</a></li> <li><a href="/w/index.php?title=SDZ_216-525&action=edit&redlink=1" class="new" title="SDZ 216-525 (page does not exist)">SDZ 216-525</a></li> <li><a href="/wiki/Spiperone" title="Spiperone">Spiperone</a></li> <li><a href="/wiki/Spiramide" title="Spiramide">Spiramide</a></li> <li><a href="/wiki/Spiroxatrine" title="Spiroxatrine">Spiroxatrine</a></li> <li><a href="/wiki/UH-301" title="UH-301">UH-301</a></li> <li><a href="/wiki/WAY-100135" title="WAY-100135">WAY-100135</a></li> <li><a href="/wiki/WAY-100635" title="WAY-100635">WAY-100635</a></li> <li><a href="/wiki/Xylamidine" title="Xylamidine">Xylamidine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Unknown/unsorted: <a href="/wiki/Acetryptine" title="Acetryptine">Acetryptine</a></li> <li><a href="/wiki/Carvedilol" title="Carvedilol">Carvedilol</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT1B_receptor" title="5-HT1B receptor">5-HT1B</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/Anpirtoline" title="Anpirtoline">Anpirtoline</a></li> <li><a href="/wiki/CGS-12066A" title="CGS-12066A">CGS-12066A</a></li> <li><a href="/wiki/CP-93129" title="CP-93129">CP-93129</a></li> <li><a href="/wiki/CP-94253" title="CP-94253">CP-94253</a></li> <li><a href="/wiki/CP-122,288" title="CP-122,288">CP-122,288</a></li> <li><a href="/wiki/CP-135807" title="CP-135807">CP-135807</a></li> <li><a href="/wiki/Eltoprazine" title="Eltoprazine">Eltoprazine</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="/wiki/Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="/wiki/Ergotamine" title="Ergotamine">ergotamine</a>, <a href="/wiki/Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a>, <a href="/wiki/Methysergide" title="Methysergide">methysergide</a>, <a href="/wiki/Pergolide" title="Pergolide">pergolide</a>)</li> <li><a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li> <li><a href="/wiki/RU-24,969" title="RU-24,969">RU-24,969</a></li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/Triptan" title="Triptan">Triptans</a> (e.g., <a href="/wiki/Avitriptan" title="Avitriptan">avitriptan</a>, <a href="/wiki/Donitriptan" title="Donitriptan">donitriptan</a>, <a href="/wiki/Eletriptan" title="Eletriptan">eletriptan</a>, <a href="/wiki/Sumatriptan" title="Sumatriptan">sumatriptan</a>, <a href="/wiki/Zolmitriptan" title="Zolmitriptan">zolmitriptan</a>)</li> <li><a href="/wiki/Trifluoromethylphenylpiperazine" title="Trifluoromethylphenylpiperazine">TFMPP</a></li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="/wiki/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="/wiki/N,N-Dimethyltryptamine" title="N,N-Dimethyltryptamine">DMT</a>)</li> <li><a href="/wiki/Vortioxetine" title="Vortioxetine">Vortioxetine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a href="/wiki/AR-A000002" title="AR-A000002">AR-A000002</a></li> <li><a href="/wiki/Beta_blocker" title="Beta blocker">Beta blockers</a> (e.g., <a href="/wiki/Alprenolol" title="Alprenolol">alprenolol</a>, <a href="/wiki/Carteolol" title="Carteolol">carteolol</a>, <a href="/wiki/Isamoltane" title="Isamoltane">isamoltane</a>, <a href="/wiki/Oxprenolol" title="Oxprenolol">oxprenolol</a>, <a href="/wiki/Penbutolol" title="Penbutolol">penbutolol</a>, <a href="/wiki/Propranolol" title="Propranolol">propranolol</a>, <a href="/wiki/Tertatolol" title="Tertatolol">tertatolol</a>)</li> <li><a href="/wiki/Elzasonan" title="Elzasonan">Elzasonan</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Metergoline" title="Metergoline">metergoline</a>)</li> <li><a href="/wiki/GR-127935" title="GR-127935">GR-127935</a></li> <li><a href="/wiki/Isamoltane" title="Isamoltane">Isamoltane</a></li> <li><a href="/wiki/LY-393558" title="LY-393558">LY-393558</a></li> <li><a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/SB-216641" title="SB-216641">SB-216641</a></li> <li><a href="/wiki/SB-224289" title="SB-224289">SB-224289</a></li> <li><a href="/wiki/SB-236057" title="SB-236057">SB-236057</a></li> <li><a href="/wiki/Yohimbine" title="Yohimbine">Yohimbine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Unknown/unsorted: <a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Cabergoline" title="Cabergoline">cabergoline</a>, <a href="/wiki/Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>, <a href="/wiki/Lisuride" title="Lisuride">lisuride</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT1D_receptor" title="5-HT1D receptor">5-HT1D</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/CP-122,288" title="CP-122,288">CP-122,288</a></li> <li><a href="/wiki/CP-135807" title="CP-135807">CP-135807</a></li> <li><a href="/w/index.php?title=CP-286601&action=edit&redlink=1" class="new" title="CP-286601 (page does not exist)">CP-286601</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="/wiki/Cabergoline" title="Cabergoline">cabergoline</a>, <a href="/wiki/Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="/wiki/Ergotamine" title="Ergotamine">ergotamine</a>, <a href="/wiki/LSD" title="LSD">LSD</a>, <a href="/wiki/Methysergide" title="Methysergide">methysergide</a>)</li> <li><a href="/w/index.php?title=GR-46611&action=edit&redlink=1" class="new" title="GR-46611 (page does not exist)">GR-46611</a></li> <li><a href="/wiki/L-694247" title="L-694247">L-694247</a></li> <li><a href="/w/index.php?title=L-772405&action=edit&redlink=1" class="new" title="L-772405 (page does not exist)">L-772405</a></li> <li><a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li> <li><a href="/w/index.php?title=PNU-109291&action=edit&redlink=1" class="new" title="PNU-109291 (page does not exist)">PNU-109291</a></li> <li><a href="/wiki/PNU-142633" title="PNU-142633">PNU-142633</a></li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/TGBA01AD" title="TGBA01AD">TGBA01AD</a></li> <li><a href="/wiki/Triptan" title="Triptan">Triptans</a> (e.g., <a href="/wiki/Almotriptan" title="Almotriptan">almotriptan</a>, <a href="/wiki/Avitriptan" title="Avitriptan">avitriptan</a>, <a href="/wiki/Donitriptan" title="Donitriptan">donitriptan</a>, <a href="/wiki/Eletriptan" title="Eletriptan">eletriptan</a>, <a href="/wiki/Frovatriptan" title="Frovatriptan">frovatriptan</a>, <a href="/wiki/Naratriptan" title="Naratriptan">naratriptan</a>, <a href="/wiki/Rizatriptan" title="Rizatriptan">rizatriptan</a>, <a href="/wiki/Sumatriptan" title="Sumatriptan">sumatriptan</a>, <a href="/wiki/Zolmitriptan" title="Zolmitriptan">zolmitriptan</a>)</li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="/wiki/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="/wiki/5-Ethyl-DMT" title="5-Ethyl-DMT">5-Et-DMT</a>, <a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="/wiki/5-(Nonyloxy)tryptamine" title="5-(Nonyloxy)tryptamine">5-(nonyloxy)tryptamine</a>, <a href="/wiki/N,N-Dimethyltryptamine" title="N,N-Dimethyltryptamine">DMT</a>)</li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a href="/wiki/Alniditan" title="Alniditan">Alniditan</a></li> <li><a href="/wiki/BRL-15,572" title="BRL-15,572">BRL-15,572</a></li> <li><a href="/wiki/Elzasonan" title="Elzasonan">Elzasonan</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Metergoline" title="Metergoline">metergoline</a>)</li> <li><a href="/wiki/GR-127935" title="GR-127935">GR-127935</a></li> <li><a href="/wiki/Ketanserin" title="Ketanserin">Ketanserin</a></li> <li><a href="/wiki/LY-310762" title="LY-310762">LY-310762</a></li> <li><a href="/wiki/LY-367642" title="LY-367642">LY-367642</a></li> <li><a href="/wiki/LY-393558" title="LY-393558">LY-393558</a></li> <li><a href="/wiki/LY-456219" title="LY-456219">LY-456219</a></li> <li><a href="/wiki/LY-456220" title="LY-456220">LY-456220</a></li> <li><a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/Mianserin" title="Mianserin">Mianserin</a></li> <li><a href="/wiki/Ritanserin" title="Ritanserin">Ritanserin</a></li> <li><a href="/wiki/Yohimbine" title="Yohimbine">Yohimbine</a></li> <li><a href="/wiki/Ziprasidone" title="Ziprasidone">Ziprasidone</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Unknown/unsorted: <a href="/wiki/Acetryptine" title="Acetryptine">Acetryptine</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Lisuride" title="Lisuride">lisuride</a>, <a href="/wiki/Lysergol" title="Lysergol">lysergol</a>, <a href="/wiki/Pergolide" title="Pergolide">pergolide</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT1E_receptor" title="5-HT1E receptor">5-HT1E</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/BRL-54443" title="BRL-54443">BRL-54443</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Methysergide" title="Methysergide">methysergide</a>)</li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/Triptan" title="Triptan">Triptans</a> (e.g., <a href="/wiki/Eletriptan" title="Eletriptan">eletriptan</a>)</li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/Tryptamine" title="Tryptamine">tryptamine</a>)</li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Unknown/unsorted: <a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>, <a href="/wiki/Lysergol" title="Lysergol">lysergol</a>, <a href="/wiki/Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT1F_receptor" title="5-HT1F receptor">5-HT1F</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/BRL-54443" title="BRL-54443">BRL-54443</a></li> <li><a href="/wiki/CP-122,288" title="CP-122,288">CP-122,288</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="/wiki/Lysergol" title="Lysergol">lysergol</a>, <a href="/wiki/Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a> <a href="/wiki/Methysergide" title="Methysergide">methysergide</a>)</li> <li><a href="/wiki/Lasmiditan" title="Lasmiditan">Lasmiditan</a></li> <li><a href="/wiki/LY-334370" title="LY-334370">LY-334370</a></li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/Triptan" title="Triptan">Triptans</a> (e.g., <a href="/wiki/Eletriptan" title="Eletriptan">eletriptan</a>, <a href="/wiki/Naratriptan" title="Naratriptan">naratriptan</a>, <a href="/wiki/Sumatriptan" title="Sumatriptan">sumatriptan</a>)</li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>)</li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/Mianserin" title="Mianserin">Mianserin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT2_receptor" title="5-HT2 receptor">5-HT2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT2A</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: 25H/NB series (e.g., <a href="/wiki/25I-NBF" title="25I-NBF">25I-NBF</a>, <a href="/wiki/25I-NBMD" title="25I-NBMD">25I-NBMD</a>, <a href="/wiki/25I-NBOH" title="25I-NBOH">25I-NBOH</a>, <a href="/wiki/25I-NBOMe" title="25I-NBOMe">25I-NBOMe</a>, <a href="/wiki/25B-NBOMe" title="25B-NBOMe">25B-NBOMe</a>, <a href="/wiki/25C-NBOMe" title="25C-NBOMe">25C-NBOMe</a>, <a href="/wiki/25TFM-NBOMe" title="25TFM-NBOMe">25TFM-NBOMe</a>, <a href="/wiki/2CBCB-NBOMe" title="2CBCB-NBOMe">2CBCB-NBOMe</a>, <a href="/wiki/25CN-NBOH" title="25CN-NBOH">25CN-NBOH</a>, <a href="/wiki/2CBFly-NBOMe" title="2CBFly-NBOMe">2CBFly-NBOMe</a>)</li> <li><a href="/wiki/2C_(psychedelics)" title="2C (psychedelics)">2Cs</a> (e.g., <a href="/wiki/2C-B" title="2C-B">2C-B</a>, <a href="/wiki/2C-E" title="2C-E">2C-E</a>, <a href="/wiki/2C-I" title="2C-I">2C-I</a>, <a href="/wiki/2C-T-2" title="2C-T-2">2C-T-2</a>, <a href="/wiki/2C-T-7" title="2C-T-7">2C-T-7</a>, <a href="/wiki/2C-T-21" title="2C-T-21">2C-T-21</a>)</li> <li><a href="/wiki/2C-B-FLY" title="2C-B-FLY">2C-B-FLY</a></li> <li><a href="/wiki/2CB-Ind" title="2CB-Ind">2CB-Ind</a></li> <li><a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-Methoxytryptamines</a> (<a href="/wiki/5-MeO-DET" title="5-MeO-DET">5-MeO-DET</a>, <a href="/wiki/5-Methoxy-N,N-diisopropyltryptamine" class="mw-redirect" title="5-Methoxy-N,N-diisopropyltryptamine">5-MeO-DiPT</a>, <a href="/wiki/5-MeO-DMT" title="5-MeO-DMT">5-MeO-DMT</a>, <a href="/wiki/5-MeO-DPT" title="5-MeO-DPT">5-MeO-DPT</a>, <a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>)</li> <li><a href="/wiki/Substituted_alpha-alkyltryptamine" class="mw-redirect" title="Substituted alpha-alkyltryptamine">α-Alkyltryptamines</a> (e.g., <a href="/wiki/5-Chloro-%CE%B1MT" title="5-Chloro-αMT">5-Cl-αMT</a>, <a href="/wiki/5-Fluoro-AMT" title="5-Fluoro-AMT">5-Fl-αMT</a>, <a href="/wiki/5-MeO-AET" title="5-MeO-AET">5-MeO-αET</a>, <a href="/wiki/5-MeO-aMT" class="mw-redirect" title="5-MeO-aMT">5-MeO-αMT</a>, <a href="/wiki/Alpha-Methylserotonin" class="mw-redirect" title="Alpha-Methylserotonin">α-Me-5-HT</a>, <a href="/wiki/Alpha-Ethyltryptamine" class="mw-redirect" title="Alpha-Ethyltryptamine">αET</a>, <a href="/wiki/Alpha-Methyltryptamine" class="mw-redirect" title="Alpha-Methyltryptamine">αMT</a>)</li> <li><a href="/wiki/AL-34662" title="AL-34662">AL-34662</a></li> <li><a href="/wiki/AL-37350A" title="AL-37350A">AL-37350A</a></li> <li><a href="/wiki/Bromo-DragonFLY" title="Bromo-DragonFLY">Bromo-DragonFLY</a></li> <li><a href="/wiki/Dimemebfe" title="Dimemebfe">Dimemebfe</a></li> <li><a href="/wiki/DMBMPP" title="DMBMPP">DMBMPP</a></li> <li><a href="/wiki/DOx" title="DOx">DOx</a> (e.g., <a href="/wiki/2,5-Dimethoxy-4-bromoamphetamine" title="2,5-Dimethoxy-4-bromoamphetamine">DOB</a>, <a href="/wiki/2,5-Dimethoxy-4-chloroamphetamine" title="2,5-Dimethoxy-4-chloroamphetamine">DOC</a>, <a href="/wiki/2,5-Dimethoxy-4-iodoamphetamine" title="2,5-Dimethoxy-4-iodoamphetamine">DOI</a>, <a href="/wiki/2,5-Dimethoxy-4-methylamphetamine" title="2,5-Dimethoxy-4-methylamphetamine">DOM</a>)</li> <li><a href="/wiki/Efavirenz" title="Efavirenz">Efavirenz</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/1P-LSD" title="1P-LSD">1P-LSD</a>, <a href="/wiki/ALD-52" title="ALD-52">ALD-52</a>, <a href="/wiki/Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="/wiki/Cabergoline" title="Cabergoline">cabergoline</a>, <a href="/wiki/Ergine" title="Ergine">ergine (LSA)</a>, <a href="/wiki/Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>, <a href="/wiki/Ergotamine" title="Ergotamine">ergotamine</a>, <a href="/wiki/Lisuride" title="Lisuride">lisuride</a>, <a href="/wiki/Lysergic_acid_2,4-dimethylazetidide" title="Lysergic acid 2,4-dimethylazetidide">LA-SS-Az</a>, <a href="/wiki/Lysergic_acid_2-butyl_amide" title="Lysergic acid 2-butyl amide">LSB</a>, <a href="/wiki/LSD" title="LSD">LSD</a>, <a href="/wiki/LSD-Pip" title="LSD-Pip">LSD-Pip</a>, <a href="/wiki/Lysergic_acid_hydroxyethylamide" title="Lysergic acid hydroxyethylamide">LSH</a>, <a href="/wiki/Lysergic_acid_3-pentyl_amide" title="Lysergic acid 3-pentyl amide">LSP</a>, <a href="/wiki/Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a>, <a href="/wiki/Pergolide" title="Pergolide">pergolide</a>)</li> <li><a href="/wiki/Flumexadol" title="Flumexadol">Flumexadol</a></li> <li><a href="/wiki/IHCH-7113" title="IHCH-7113">IHCH-7113</a></li> <li><a href="/wiki/Jimscaline" title="Jimscaline">Jimscaline</a></li> <li><a href="/wiki/Lorcaserin" title="Lorcaserin">Lorcaserin</a></li> <li><a href="/wiki/Substituted_methylenedioxyphenethylamine" title="Substituted methylenedioxyphenethylamine">MDxx</a> (e.g., <a href="/wiki/3,4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA (tenamfetamine)</a>, <a href="/wiki/MDMA" title="MDMA">MDMA (midomafetamine)</a>, <a href="/wiki/3,4-Methylenedioxy-N-hydroxyamphetamine" title="3,4-Methylenedioxy-N-hydroxyamphetamine">MDOH</a>, <a href="/wiki/MMDA_(drug)" title="MMDA (drug)">MMDA</a>)</li> <li><a href="/wiki/O-4310" title="O-4310">O-4310</a></li> <li><a href="/wiki/Oxaflozane" title="Oxaflozane">Oxaflozane</a></li> <li><a href="/wiki/PHA-57378" title="PHA-57378">PHA-57378</a></li> <li><a href="/wiki/PNU-22394" title="PNU-22394">PNU-22394</a></li> <li><a href="/wiki/PNU-181731" title="PNU-181731">PNU-181731</a></li> <li><a href="/wiki/RH-34" title="RH-34">RH-34</a></li> <li><a href="/wiki/SCHEMBL5334361" title="SCHEMBL5334361">SCHEMBL5334361</a></li> <li><a href="/wiki/Substituted_phenethylamine" title="Substituted phenethylamine">Phenethylamines</a> (e.g., <a href="/wiki/Lophophine" title="Lophophine">lophophine</a>, <a href="/wiki/Mescaline" title="Mescaline">mescaline</a>)</li> <li><a href="/wiki/Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="/wiki/Benzylpiperazine" title="Benzylpiperazine">BZP</a>, <a href="/wiki/Quipazine" title="Quipazine">quipazine</a>, <a href="/wiki/Trifluoromethylphenylpiperazine" title="Trifluoromethylphenylpiperazine">TFMPP</a>)</li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/TCB-2" title="TCB-2">TCB-2</a></li> <li><a href="/wiki/TFMFly" title="TFMFly">TFMFly</a></li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="/wiki/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="/wiki/Bufotenin" title="Bufotenin">bufotenin</a>, <a href="/wiki/Diethyltryptamine" title="Diethyltryptamine">DET</a>, <a href="/wiki/Diisopropyltryptamine" class="mw-redirect" title="Diisopropyltryptamine">DiPT</a>, <a href="/wiki/N,N-Dimethyltryptamine" title="N,N-Dimethyltryptamine">DMT</a>, <a href="/wiki/Dipropyltryptamine" title="Dipropyltryptamine">DPT</a>, <a href="/wiki/Psilocin" title="Psilocin">psilocin</a>, <a href="/wiki/Psilocybin" title="Psilocybin">psilocybin</a>, <a href="/wiki/Tryptamine" title="Tryptamine">tryptamine</a>)</li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a href="/wiki/5-I-R91150" title="5-I-R91150">5-I-R91150</a></li> <li><a href="/wiki/5-MeO-NBpBrT" title="5-MeO-NBpBrT">5-MeO-NBpBrT</a></li> <li><a href="/wiki/AC-90179" title="AC-90179">AC-90179</a></li> <li><a href="/wiki/Adatanserin" title="Adatanserin">Adatanserin</a></li> <li><a href="/wiki/Altanserin" title="Altanserin">Altanserin</a></li> <li><a href="/wiki/Antihistamine" title="Antihistamine">Antihistamines</a> (e.g., <a href="/wiki/Cyproheptadine" title="Cyproheptadine">cyproheptadine</a>, <a href="/wiki/Hydroxyzine" title="Hydroxyzine">hydroxyzine</a>, <a href="/wiki/Ketotifen" title="Ketotifen">ketotifen</a>, <a href="/wiki/Perlapine" title="Perlapine">perlapine</a>)</li> <li><a href="/wiki/9-Aminomethyl-9,10-dihydroanthracene" title="9-Aminomethyl-9,10-dihydroanthracene">AMDA</a></li> <li><a class="mw-selflink selflink">Atypical antipsychotics</a> (e.g., <a href="/wiki/Amperozide" title="Amperozide">amperozide</a>, <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="/wiki/Asenapine" title="Asenapine">asenapine</a>, <a href="/wiki/Blonanserin" title="Blonanserin">blonanserin</a>, <a href="/wiki/Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>, <a href="/wiki/Carpipramine" title="Carpipramine">carpipramine</a>, <a href="/wiki/Clocapramine" title="Clocapramine">clocapramine</a>, <a href="/wiki/Clorotepine" title="Clorotepine">clorotepine</a>, <a href="/wiki/Clozapine" title="Clozapine">clozapine</a>, <a href="/wiki/Fluperlapine" title="Fluperlapine">fluperlapine</a>, <a href="/wiki/Gevotroline" title="Gevotroline">gevotroline</a>, <a href="/wiki/Iloperidone" title="Iloperidone">iloperidone</a>, <a href="/wiki/Lurasidone" title="Lurasidone">lurasidone</a>, <a href="/wiki/Melperone" title="Melperone">melperone</a>, <a href="/wiki/Mosapramine" title="Mosapramine">mosapramine</a>, <a href="/wiki/Ocaperidone" title="Ocaperidone">ocaperidone</a>, <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a>, <a href="/wiki/Paliperidone" title="Paliperidone">paliperidone</a>, <a href="/wiki/Quetiapine" title="Quetiapine">quetiapine</a>, <a href="/wiki/Risperidone" title="Risperidone">risperidone</a>, <a href="/wiki/Sertindole" title="Sertindole">sertindole</a>, <a href="/wiki/Zicronapine" title="Zicronapine">zicronapine</a>, <a href="/wiki/Ziprasidone" title="Ziprasidone">ziprasidone</a>, <a href="/wiki/Zotepine" title="Zotepine">zotepine</a>)</li> <li><a href="/wiki/Chlorprothixene" title="Chlorprothixene">Chlorprothixene</a></li> <li><a href="/wiki/Cinanserin" title="Cinanserin">Cinanserin</a></li> <li><a href="/wiki/CSP-2503" title="CSP-2503">CSP-2503</a></li> <li><a href="/wiki/Deramciclane" title="Deramciclane">Deramciclane</a></li> <li><a href="/wiki/Dotarizine" title="Dotarizine">Dotarizine</a></li> <li><a href="/wiki/Eplivanserin" title="Eplivanserin">Eplivanserin</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Amesergide" title="Amesergide">amesergide</a>, <a href="/w/index.php?title=LY-53857&action=edit&redlink=1" class="new" title="LY-53857 (page does not exist)">LY-53857</a>, <a href="/wiki/LY-215,840" title="LY-215,840">LY-215,840</a>, <a href="/wiki/Mesulergine" title="Mesulergine">mesulergine</a>, <a href="/wiki/Metergoline" title="Metergoline">metergoline</a>, <a href="/wiki/Methysergide" title="Methysergide">methysergide</a>, <a href="/wiki/Sergolexole" title="Sergolexole">sergolexole</a>)</li> <li><a href="/wiki/Fananserin" title="Fananserin">Fananserin</a></li> <li><a href="/wiki/Flibanserin" title="Flibanserin">Flibanserin</a></li> <li><a href="/wiki/Glemanserin" title="Glemanserin">Glemanserin</a></li> <li><a href="/w/index.php?title=Irindalone&action=edit&redlink=1" class="new" title="Irindalone (page does not exist)">Irindalone</a></li> <li><a href="/wiki/Ketanserin" title="Ketanserin">Ketanserin</a></li> <li><a href="/wiki/KML-010" title="KML-010">KML-010</a></li> <li><a href="/w/index.php?title=Landipirdine&action=edit&redlink=1" class="new" title="Landipirdine (page does not exist)">Landipirdine</a></li> <li><a href="/wiki/LY-393558" title="LY-393558">LY-393558</a></li> <li><a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li> <li><a href="/wiki/Medifoxamine" title="Medifoxamine">Medifoxamine</a></li> <li><a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/MIN-117" title="MIN-117">MIN-117 (WF-516)</a></li> <li><a href="/wiki/Naftidrofuryl" title="Naftidrofuryl">Naftidrofuryl</a></li> <li><a href="/wiki/Nantenine" title="Nantenine">Nantenine</a></li> <li><a href="/wiki/Nelotanserin" title="Nelotanserin">Nelotanserin</a></li> <li><a href="/wiki/Opiranserin" title="Opiranserin">Opiranserin (VVZ-149)</a></li> <li><a href="/wiki/Pelanserin" title="Pelanserin">Pelanserin</a></li> <li><a href="/wiki/Phenoxybenzamine" title="Phenoxybenzamine">Phenoxybenzamine</a></li> <li><a href="/wiki/Pimavanserin" title="Pimavanserin">Pimavanserin</a></li> <li><a href="/wiki/Pirenperone" title="Pirenperone">Pirenperone</a></li> <li><a href="/wiki/Pizotifen" title="Pizotifen">Pizotifen</a></li> <li><a href="/wiki/Pruvanserin" title="Pruvanserin">Pruvanserin</a></li> <li><a href="/wiki/Rauwolscine" title="Rauwolscine">Rauwolscine</a></li> <li><a href="/wiki/Ritanserin" title="Ritanserin">Ritanserin</a></li> <li><a href="/wiki/Roluperidone" title="Roluperidone">Roluperidone</a></li> <li><a href="/wiki/S-14671" title="S-14671">S-14671</a></li> <li><a href="/wiki/Sarpogrelate" title="Sarpogrelate">Sarpogrelate</a></li> <li><a href="/wiki/Serotonin_antagonist_and_reuptake_inhibitor" title="Serotonin antagonist and reuptake inhibitor">Serotonin antagonists and reuptake inhibitors</a> (e.g., <a href="/wiki/Etoperidone" title="Etoperidone">etoperidone</a>, <a href="/wiki/Hydroxynefazodone" title="Hydroxynefazodone">hydroxynefazodone</a>, <a href="/wiki/Lubazodone" title="Lubazodone">lubazodone</a>, <a href="/wiki/Mepiprazole" title="Mepiprazole">mepiprazole</a>, <a href="/wiki/Nefazodone" title="Nefazodone">nefazodone</a>, <a href="/wiki/Triazoledione" title="Triazoledione">triazoledione</a>, <a href="/wiki/Trazodone" title="Trazodone">trazodone</a>)</li> <li><a href="/w/index.php?title=SR-46349B&action=edit&redlink=1" class="new" title="SR-46349B (page does not exist)">SR-46349B</a></li> <li><a href="/wiki/TGBA01AD" title="TGBA01AD">TGBA01AD</a></li> <li><a href="/wiki/Teniloxazine" title="Teniloxazine">Teniloxazine</a></li> <li><a href="/w/index.php?title=Temanogrel&action=edit&redlink=1" class="new" title="Temanogrel (page does not exist)">Temanogrel</a></li> <li><a href="/wiki/Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="/wiki/Amoxapine" title="Amoxapine">amoxapine</a>, <a href="/wiki/Aptazapine" title="Aptazapine">aptazapine</a>, <a href="/wiki/Esmirtazapine" title="Esmirtazapine">esmirtazapine</a>, <a href="/wiki/Maprotiline" title="Maprotiline">maprotiline</a>, <a href="/wiki/Mianserin" title="Mianserin">mianserin</a>, <a href="/wiki/Mirtazapine" title="Mirtazapine">mirtazapine</a>)</li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="/wiki/Amitriptyline" title="Amitriptyline">amitriptyline</a>)</li> <li><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="/wiki/Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>, <a href="/wiki/Fluphenazine" title="Fluphenazine">fluphenazine</a>, <a href="/wiki/Haloperidol" title="Haloperidol">haloperidol</a>, <a href="/wiki/Loxapine" title="Loxapine">loxapine</a>, <a href="/wiki/Perphenazine" title="Perphenazine">perphenazine</a>, <a href="/wiki/Pimozide" title="Pimozide">pimozide</a>, <a href="/wiki/Pipamperone" title="Pipamperone">pipamperone</a>, <a href="/wiki/Prochlorperazine" title="Prochlorperazine">prochlorperazine</a>, <a href="/wiki/Setoperone" title="Setoperone">setoperone</a>, <a href="/wiki/Spiperone" title="Spiperone">spiperone</a>, <a href="/wiki/Spiramide" title="Spiramide">spiramide</a>, <a href="/wiki/Thioridazine" title="Thioridazine">thioridazine</a>, <a href="/wiki/Tiotixene" title="Tiotixene">thiothixene</a>, <a href="/wiki/Trifluoperazine" title="Trifluoperazine">trifluoperazine</a>)</li> <li><a href="/wiki/Volinanserin" title="Volinanserin">Volinanserin</a></li> <li><a href="/wiki/Xylamidine" title="Xylamidine">Xylamidine</a></li> <li><a href="/wiki/Yohimbine" title="Yohimbine">Yohimbine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Unknown/unsorted: <a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="/wiki/Nicergoline" title="Nicergoline">nicergoline</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT2B_receptor" title="5-HT2B receptor">5-HT2B</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/4-Methylaminorex" title="4-Methylaminorex">4-Methylaminorex</a></li> <li><a href="/wiki/Aminorex" title="Aminorex">Aminorex</a></li> <li><a href="/wiki/Substituted_amphetamine" title="Substituted amphetamine">Amphetamines</a> (e.g., <a href="/wiki/Chlorphentermine" title="Chlorphentermine">chlorphentermine</a>, <a href="/wiki/Cloforex" title="Cloforex">cloforex</a>, <a href="/wiki/Dexfenfluramine" title="Dexfenfluramine">dexfenfluramine</a>, <a href="/wiki/Fenfluramine" title="Fenfluramine">fenfluramine</a>, <a href="/wiki/Levofenfluramine" title="Levofenfluramine">levofenfluramine</a>, <a href="/wiki/Norfenfluramine" title="Norfenfluramine">norfenfluramine</a>)</li> <li><a href="/wiki/BW-723C86" title="BW-723C86">BW-723C86</a></li> <li><a href="/wiki/DOx" title="DOx">DOx</a> (e.g., <a href="/wiki/2,5-Dimethoxy-4-bromoamphetamine" title="2,5-Dimethoxy-4-bromoamphetamine">DOB</a>, <a href="/wiki/2,5-Dimethoxy-4-chloroamphetamine" title="2,5-Dimethoxy-4-chloroamphetamine">DOC</a>, <a href="/wiki/2,5-Dimethoxy-4-iodoamphetamine" title="2,5-Dimethoxy-4-iodoamphetamine">DOI</a>, <a href="/wiki/2,5-Dimethoxy-4-methylamphetamine" title="2,5-Dimethoxy-4-methylamphetamine">DOM</a>)</li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Cabergoline" title="Cabergoline">cabergoline</a>, <a href="/wiki/Dihydroergocryptine" title="Dihydroergocryptine">dihydroergocryptine</a>, <a href="/wiki/Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="/wiki/Ergotamine" title="Ergotamine">ergotamine</a>, <a href="/wiki/Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a>, <a href="/wiki/Methysergide" title="Methysergide">methysergide</a>, <a href="/wiki/Pergolide" title="Pergolide">pergolide</a>)</li> <li><a href="/wiki/Lorcaserin" title="Lorcaserin">Lorcaserin</a></li> <li><a href="/wiki/Substituted_methylenedioxyphenethylamine" title="Substituted methylenedioxyphenethylamine">MDxx</a> (e.g., <a href="/wiki/3,4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA (tenamfetamine)</a>, <a href="/wiki/MDMA" title="MDMA">MDMA (midomafetamine)</a>, <a href="/wiki/3,4-Methylenedioxy-N-hydroxyamphetamine" title="3,4-Methylenedioxy-N-hydroxyamphetamine">MDOH</a>, <a href="/wiki/MMDA_(drug)" title="MMDA (drug)">MMDA</a>)</li> <li><a href="/wiki/Substituted_piperazine" title="Substituted piperazine">Piperazines</a> (e.g., <a href="/wiki/Trifluoromethylphenylpiperazine" title="Trifluoromethylphenylpiperazine">TFMPP</a>)</li> <li><a href="/wiki/PNU-22394" title="PNU-22394">PNU-22394</a></li> <li><a href="/wiki/Ro60-0175" title="Ro60-0175">Ro60-0175</a></li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="/wiki/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="/wiki/Alpha-Methylserotonin" class="mw-redirect" title="Alpha-Methylserotonin">α-Me-5-HT</a>, <a href="/wiki/Bufotenin" title="Bufotenin">bufotenin</a>, <a href="/wiki/Diethyltryptamine" title="Diethyltryptamine">DET</a>, <a href="/wiki/Diisopropyltryptamine" class="mw-redirect" title="Diisopropyltryptamine">DiPT</a>, <a href="/wiki/N,N-Dimethyltryptamine" title="N,N-Dimethyltryptamine">DMT</a>, <a href="/wiki/Dipropyltryptamine" title="Dipropyltryptamine">DPT</a>, <a href="/wiki/Psilocin" title="Psilocin">psilocin</a>, <a href="/wiki/Psilocybin" title="Psilocybin">psilocybin</a>, <a href="/wiki/Tryptamine" title="Tryptamine">tryptamine</a>)</li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a href="/wiki/Agomelatine" title="Agomelatine">Agomelatine</a></li> <li><a class="mw-selflink selflink">Atypical antipsychotics</a> (e.g., <a href="/wiki/Amisulpride" title="Amisulpride">amisulpride</a>, <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="/wiki/Asenapine" title="Asenapine">asenapine</a>, <a href="/wiki/Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>, <a href="/wiki/Cariprazine" title="Cariprazine">cariprazine</a>, <a href="/wiki/Clozapine" title="Clozapine">clozapine</a>, <a href="/w/index.php?title=N-desalkylquetiapine&action=edit&redlink=1" class="new" title="N-desalkylquetiapine (page does not exist)">N-desalkylquetiapine (norquetiapine)</a>, <a href="/wiki/Desmethylclozapine" title="Desmethylclozapine">N-desmethylclozapine (norclozapine)</a>, <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a>, <a href="/wiki/Pipamperone" title="Pipamperone">pipamperone</a>, <a href="/wiki/Quetiapine" title="Quetiapine">quetiapine</a>, <a href="/wiki/Risperidone" title="Risperidone">risperidone</a>, <a href="/wiki/Ziprasidone" title="Ziprasidone">ziprasidone</a>)</li> <li><a href="/wiki/Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a></li> <li><a href="/wiki/EGIS-7625" title="EGIS-7625">EGIS-7625</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Amesergide" title="Amesergide">amesergide</a>, <a href="/wiki/Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="/wiki/Lisuride" title="Lisuride">lisuride</a>, <a href="/w/index.php?title=LY-53857&action=edit&redlink=1" class="new" title="LY-53857 (page does not exist)">LY-53857</a>, <a href="/wiki/LY-272,015" title="LY-272,015">LY-272015</a>, <a href="/wiki/Mesulergine" title="Mesulergine">mesulergine</a>)</li> <li><a href="/wiki/Ketanserin" title="Ketanserin">Ketanserin</a></li> <li><a href="/wiki/LY-393558" title="LY-393558">LY-393558</a></li> <li><a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li> <li><a href="/wiki/Metadoxine" title="Metadoxine">Metadoxine</a></li> <li><a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/Pirenperone" title="Pirenperone">Pirenperone</a></li> <li><a href="/wiki/Pizotifen" title="Pizotifen">Pizotifen</a></li> <li><a href="/wiki/Propranolol" title="Propranolol">Propranolol</a></li> <li><a href="/wiki/PRX-08066" title="PRX-08066">PRX-08066</a></li> <li><a href="/wiki/Rauwolscine" title="Rauwolscine">Rauwolscine</a></li> <li><a href="/wiki/Ritanserin" title="Ritanserin">Ritanserin</a></li> <li><a href="/wiki/RS-127445" title="RS-127445">RS-127445</a></li> <li><a href="/wiki/Sarpogrelate" title="Sarpogrelate">Sarpogrelate</a></li> <li><a href="/wiki/SB-200646" title="SB-200646">SB-200646</a></li> <li><a href="/wiki/SB-204741" title="SB-204741">SB-204741</a></li> <li><a href="/wiki/SB-206553" title="SB-206553">SB-206553</a></li> <li><a href="/wiki/SB-215505" title="SB-215505">SB-215505</a></li> <li><a href="/wiki/SB-221284" title="SB-221284">SB-221284</a></li> <li><a href="/wiki/SB-228357" title="SB-228357">SB-228357</a></li> <li><a href="/wiki/SDZ_SER-082" title="SDZ SER-082">SDZ SER-082</a></li> <li><a href="/wiki/Tegaserod" title="Tegaserod">Tegaserod</a></li> <li><a href="/wiki/Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="/wiki/Amoxapine" title="Amoxapine">amoxapine</a>, <a href="/wiki/Mianserin" title="Mianserin">mianserin</a>, <a href="/wiki/Mirtazapine" title="Mirtazapine">mirtazapine</a>)</li> <li><a href="/wiki/Trazodone" title="Trazodone">Trazodone</a></li> <li><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="/wiki/Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>)</li> <li><a href="/wiki/TIK-301" title="TIK-301">TIK-301</a></li> <li><a href="/wiki/Yohimbine" title="Yohimbine">Yohimbine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Unknown/unsorted: <a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">5-HT2C</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/2C_(psychedelics)" title="2C (psychedelics)">2Cs</a> (e.g., <a href="/wiki/2C-B" title="2C-B">2C-B</a>, <a href="/wiki/2C-E" title="2C-E">2C-E</a>, <a href="/wiki/2C-I" title="2C-I">2C-I</a>, <a href="/wiki/2C-T-2" title="2C-T-2">2C-T-2</a>, <a href="/wiki/2C-T-7" title="2C-T-7">2C-T-7</a>, <a href="/wiki/2C-T-21" title="2C-T-21">2C-T-21</a>)</li> <li><a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-Methoxytryptamines</a> (<a href="/wiki/5-MeO-DET" title="5-MeO-DET">5-MeO-DET</a>, <a href="/wiki/5-Methoxy-N,N-diisopropyltryptamine" class="mw-redirect" title="5-Methoxy-N,N-diisopropyltryptamine">5-MeO-DiPT</a>, <a href="/wiki/5-MeO-DMT" title="5-MeO-DMT">5-MeO-DMT</a>, <a href="/wiki/5-MeO-DPT" title="5-MeO-DPT">5-MeO-DPT</a>, <a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>)</li> <li><a href="/wiki/Substituted_alpha-alkyltryptamine" class="mw-redirect" title="Substituted alpha-alkyltryptamine">α-Alkyltryptamines</a> (e.g., <a href="/wiki/5-Chloro-%CE%B1MT" title="5-Chloro-αMT">5-Cl-αMT</a>, <a href="/wiki/5-Fluoro-AMT" title="5-Fluoro-AMT">5-Fl-αMT</a>, <a href="/wiki/5-MeO-AET" title="5-MeO-AET">5-MeO-αET</a>, <a href="/wiki/5-MeO-aMT" class="mw-redirect" title="5-MeO-aMT">5-MeO-αMT</a>, <a href="/wiki/Alpha-Methylserotonin" class="mw-redirect" title="Alpha-Methylserotonin">α-Me-5-HT</a>, <a href="/wiki/Alpha-Ethyltryptamine" class="mw-redirect" title="Alpha-Ethyltryptamine">αET</a>, <a href="/wiki/Alpha-Methyltryptamine" class="mw-redirect" title="Alpha-Methyltryptamine">αMT</a>)</li> <li><a href="/wiki/A-372159" title="A-372159">A-372159</a></li> <li><a href="/wiki/AL-38022A" title="AL-38022A">AL-38022A</a></li> <li><a href="/wiki/Alstonine" title="Alstonine">Alstonine</a></li> <li><a href="/wiki/CP-809101" title="CP-809101">CP-809101</a></li> <li><a href="/wiki/Dimemebfe" title="Dimemebfe">Dimemebfe</a></li> <li><a href="/wiki/DOx" title="DOx">DOx</a> (e.g., <a href="/wiki/2,5-Dimethoxy-4-bromoamphetamine" title="2,5-Dimethoxy-4-bromoamphetamine">DOB</a>, <a href="/wiki/2,5-Dimethoxy-4-chloroamphetamine" title="2,5-Dimethoxy-4-chloroamphetamine">DOC</a>, <a href="/wiki/2,5-Dimethoxy-4-iodoamphetamine" title="2,5-Dimethoxy-4-iodoamphetamine">DOI</a>, <a href="/wiki/2,5-Dimethoxy-4-methylamphetamine" title="2,5-Dimethoxy-4-methylamphetamine">DOM</a>)</li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/ALD-52" title="ALD-52">ALD-52</a>, <a href="/wiki/Cabergoline" title="Cabergoline">cabergoline</a>, <a href="/wiki/Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="/wiki/Ergine" title="Ergine">ergine (LSA)</a>, <a href="/wiki/Ergotamine" title="Ergotamine">ergotamine</a>, <a href="/wiki/Lisuride" title="Lisuride">lisuride</a>, <a href="/wiki/Lysergic_acid_2,4-dimethylazetidide" title="Lysergic acid 2,4-dimethylazetidide">LA-SS-Az</a>, <a href="/wiki/Lysergic_acid_2-butyl_amide" title="Lysergic acid 2-butyl amide">LSB</a>, <a href="/wiki/LSD" title="LSD">LSD</a>, <a href="/wiki/LSD-Pip" title="LSD-Pip">LSD-Pip</a>, <a href="/wiki/Lysergic_acid_hydroxyethylamide" title="Lysergic acid hydroxyethylamide">LSH</a>, <a href="/wiki/Lysergic_acid_3-pentyl_amide" title="Lysergic acid 3-pentyl amide">LSP</a>, <a href="/wiki/Pergolide" title="Pergolide">pergolide</a>)</li> <li><a href="/wiki/Flumexadol" title="Flumexadol">Flumexadol</a></li> <li><a href="/wiki/Lorcaserin" title="Lorcaserin">Lorcaserin</a></li> <li><a href="/wiki/Substituted_methylenedioxyphenethylamine" title="Substituted methylenedioxyphenethylamine">MDxx</a> (e.g., <a href="/wiki/3,4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA (tenamfetamine)</a>, <a href="/wiki/MDMA" title="MDMA">MDMA (midomafetamine)</a>, <a href="/wiki/3,4-Methylenedioxy-N-hydroxyamphetamine" title="3,4-Methylenedioxy-N-hydroxyamphetamine">MDOH</a>, <a href="/wiki/MMDA_(drug)" title="MMDA (drug)">MMDA</a>)</li> <li><a href="/wiki/MK-212" title="MK-212">MK-212</a></li> <li><a href="/wiki/ORG-12962" title="ORG-12962">ORG-12962</a></li> <li><a href="/wiki/ORG-37684" title="ORG-37684">ORG-37684</a></li> <li><a href="/wiki/Oxaflozane" title="Oxaflozane">Oxaflozane</a></li> <li><a href="/wiki/PHA-57378" title="PHA-57378">PHA-57378</a></li> <li><a href="/wiki/Substituted_phenethylamine" title="Substituted phenethylamine">Phenethylamines</a> (e.g., <a href="/wiki/Lophophine" title="Lophophine">lophophine</a>, <a href="/wiki/Mescaline" title="Mescaline">mescaline</a>)</li> <li><a href="/wiki/Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="/wiki/Benzylpiperazine" title="Benzylpiperazine">BZP</a>, <a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a>, <a href="/wiki/Quipazine" title="Quipazine">quipazine</a>, <a href="/wiki/Trifluoromethylphenylpiperazine" title="Trifluoromethylphenylpiperazine">TFMPP</a>)</li> <li><a href="/wiki/PNU-22394" title="PNU-22394">PNU-22394</a></li> <li><a href="/wiki/PNU-181731" title="PNU-181731">PNU-181731</a></li> <li><a href="/wiki/Ro60-0175" title="Ro60-0175">Ro60-0175</a></li> <li><a href="/wiki/Ro60-0213" title="Ro60-0213">Ro60-0213</a></li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="/wiki/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="/wiki/Bufotenin" title="Bufotenin">bufotenin</a>, <a href="/wiki/Diethyltryptamine" title="Diethyltryptamine">DET</a>, <a href="/wiki/Diisopropyltryptamine" class="mw-redirect" title="Diisopropyltryptamine">DiPT</a>, <a href="/wiki/N,N-Dimethyltryptamine" title="N,N-Dimethyltryptamine">DMT</a>, <a href="/wiki/Dipropyltryptamine" title="Dipropyltryptamine">DPT</a>, <a href="/wiki/Psilocin" title="Psilocin">psilocin</a>, <a href="/wiki/Psilocybin" title="Psilocybin">psilocybin</a>, <a href="/wiki/Tryptamine" title="Tryptamine">tryptamine</a>)</li> <li><a href="/wiki/Vabicaserin" title="Vabicaserin">Vabicaserin</a></li> <li><a href="/wiki/WAY-629" title="WAY-629">WAY-629</a></li> <li><a href="/wiki/WAY-161503" title="WAY-161503">WAY-161503</a></li> <li><a href="/wiki/YM-348" title="YM-348">YM-348</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a href="/wiki/Adatanserin" title="Adatanserin">Adatanserin</a></li> <li><a href="/wiki/Agomelatine" title="Agomelatine">Agomelatine</a></li> <li><a class="mw-selflink selflink">Atypical antipsychotics</a> (e.g., <a href="/wiki/Asenapine" title="Asenapine">asenapine</a>, <a href="/wiki/Clorotepine" title="Clorotepine">clorotepine</a>, <a href="/wiki/Clozapine" title="Clozapine">clozapine</a>, <a href="/wiki/Fluperlapine" title="Fluperlapine">fluperlapine</a>, <a href="/wiki/Iloperidone" title="Iloperidone">iloperidone</a>, <a href="/wiki/Melperone" title="Melperone">melperone</a>, <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a>, <a href="/wiki/Paliperidone" title="Paliperidone">paliperidone</a>, <a href="/wiki/Quetiapine" title="Quetiapine">quetiapine</a>, <a href="/wiki/Risperidone" title="Risperidone">risperidone</a>, <a href="/wiki/Sertindole" title="Sertindole">sertindole</a>, <a href="/wiki/Ziprasidone" title="Ziprasidone">ziprasidone</a>, <a href="/wiki/Zotepine" title="Zotepine">zotepine</a>)</li> <li><a href="/wiki/Captodiame" title="Captodiame">Captodiame</a></li> <li><a href="/wiki/6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide" title="6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide">CEPC</a></li> <li><a href="/wiki/Cinanserin" title="Cinanserin">Cinanserin</a></li> <li><a href="/wiki/Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a></li> <li><a href="/wiki/Deramciclane" title="Deramciclane">Deramciclane</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol</a></li> <li><a href="/wiki/Dotarizine" title="Dotarizine">Dotarizine</a></li> <li><a href="/wiki/Eltoprazine" title="Eltoprazine">Eltoprazine</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Amesergide" title="Amesergide">amesergide</a>, <a href="/wiki/Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="/w/index.php?title=LY-53857&action=edit&redlink=1" class="new" title="LY-53857 (page does not exist)">LY-53857</a>, <a href="/wiki/LY-215,840" title="LY-215,840">LY-215,840</a>, <a href="/wiki/Mesulergine" title="Mesulergine">mesulergine</a>, <a href="/wiki/Metergoline" title="Metergoline">metergoline</a>, <a href="/wiki/Methysergide" title="Methysergide">methysergide</a>, <a href="/wiki/Sergolexole" title="Sergolexole">sergolexole</a>)</li> <li><a href="/wiki/Etoperidone" title="Etoperidone">Etoperidone</a></li> <li><a href="/wiki/Fluoxetine" title="Fluoxetine">Fluoxetine</a></li> <li><a href="/w/index.php?title=FR-260010&action=edit&redlink=1" class="new" title="FR-260010 (page does not exist)">FR-260010</a></li> <li><a href="/w/index.php?title=Irindalone&action=edit&redlink=1" class="new" title="Irindalone (page does not exist)">Irindalone</a></li> <li><a href="/wiki/Ketanserin" title="Ketanserin">Ketanserin</a></li> <li><a href="/wiki/Ketotifen" title="Ketotifen">Ketotifen</a></li> <li><a href="/wiki/Latrepirdine" title="Latrepirdine">Latrepirdine (dimebolin)</a></li> <li><a href="/wiki/Medifoxamine" title="Medifoxamine">Medifoxamine</a></li> <li><a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/Nefazodone" title="Nefazodone">Nefazodone</a></li> <li><a href="/wiki/Pirenperone" title="Pirenperone">Pirenperone</a></li> <li><a href="/wiki/Pizotifen" title="Pizotifen">Pizotifen</a></li> <li><a href="/wiki/Propranolol" title="Propranolol">Propranolol</a></li> <li><a href="/wiki/Ritanserin" title="Ritanserin">Ritanserin</a></li> <li><a href="/wiki/RS-102221" title="RS-102221">RS-102221</a></li> <li><a href="/wiki/S-14671" title="S-14671">S-14671</a></li> <li><a href="/wiki/SB-200646" title="SB-200646">SB-200646</a></li> <li><a href="/wiki/SB-206553" title="SB-206553">SB-206553</a></li> <li><a href="/wiki/SB-221284" title="SB-221284">SB-221284</a></li> <li><a href="/wiki/SB-228357" title="SB-228357">SB-228357</a></li> <li><a href="/wiki/SB-242084" title="SB-242084">SB-242084</a></li> <li><a href="/wiki/SB-243213" title="SB-243213">SB-243213</a></li> <li><a href="/wiki/SDZ_SER-082" title="SDZ SER-082">SDZ SER-082</a></li> <li><a href="/wiki/Tedatioxetine" title="Tedatioxetine">Tedatioxetine</a></li> <li><a href="/wiki/Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="/wiki/Amoxapine" title="Amoxapine">amoxapine</a>, <a href="/wiki/Aptazapine" title="Aptazapine">aptazapine</a>, <a href="/wiki/Esmirtazapine" title="Esmirtazapine">esmirtazapine</a>, <a href="/wiki/Maprotiline" title="Maprotiline">maprotiline</a>, <a href="/wiki/Mianserin" title="Mianserin">mianserin</a>, <a href="/wiki/Mirtazapine" title="Mirtazapine">mirtazapine</a>)</li> <li><a href="/wiki/TIK-301" title="TIK-301">TIK-301</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a></li> <li><a href="/wiki/Trazodone" title="Trazodone">Trazodone</a></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="/wiki/Amitriptyline" title="Amitriptyline">amitriptyline</a>, <a href="/wiki/Nortriptyline" title="Nortriptyline">nortriptyline</a>)</li> <li><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="/wiki/Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>, <a href="/wiki/Loxapine" title="Loxapine">loxapine</a>, <a href="/wiki/Pimozide" title="Pimozide">pimozide</a>, <a href="/wiki/Pipamperone" title="Pipamperone">pipamperone</a>, <a href="/wiki/Thioridazine" title="Thioridazine">thioridazine</a>)</li> <li><a href="/wiki/Xylamidine" title="Xylamidine">Xylamidine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Unknown/unsorted: <a href="/wiki/Efavirenz" title="Efavirenz">Efavirenz</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>, <a href="/wiki/Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT3_receptor" title="5-HT3 receptor">5-HT3</a>–<a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT3_receptor" title="5-HT3 receptor">5-HT3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/Alcohol_(chemistry)" title="Alcohol (chemistry)">Alcohols</a> (e.g., <a href="/wiki/N-Butanol" class="mw-redirect" title="N-Butanol">butanol</a>, <a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">ethanol (alcohol)</a>, <a href="/wiki/2,2,2-Trichloroethanol" title="2,2,2-Trichloroethanol">trichloroethanol</a>)</li> <li><a href="/wiki/Chlorophenylbiguanide" title="Chlorophenylbiguanide">m-CPBG</a></li> <li><a href="/wiki/Phenylbiguanide" title="Phenylbiguanide">Phenylbiguanide</a></li> <li><a href="/wiki/Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="/wiki/Benzylpiperazine" title="Benzylpiperazine">BZP</a>, <a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a>, <a href="/wiki/Quipazine" title="Quipazine">quipazine</a>)</li> <li><a href="/wiki/RS-56812" title="RS-56812">RS-56812</a></li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/SR-57227" title="SR-57227">SR-57227</a></li> <li><a href="/w/index.php?title=SR-57227A&action=edit&redlink=1" class="new" title="SR-57227A (page does not exist)">SR-57227A</a></li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/2-Methyl-5-hydroxytryptamine" title="2-Methyl-5-hydroxytryptamine">2-Me-5-HT</a>, <a href="/wiki/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="/wiki/Bufotenidine" title="Bufotenidine">bufotenidine (5-HTQ)</a>)</li> <li><a href="/wiki/Inhalational_anaesthetic" class="mw-redirect" title="Inhalational anaesthetic">Volatiles/gases</a> (e.g., <a href="/wiki/Halothane" title="Halothane">halothane</a>, <a href="/wiki/Isoflurane" title="Isoflurane">isoflurane</a>, <a href="/wiki/Toluene" title="Toluene">toluene</a>, <a href="/wiki/1,1,1-Trichloroethane" title="1,1,1-Trichloroethane">trichloroethane</a>)</li> <li><a href="/wiki/YM-31636" title="YM-31636">YM-31636</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a href="/wiki/Alosetron" title="Alosetron">Alosetron</a></li> <li><a href="/wiki/Anpirtoline" title="Anpirtoline">Anpirtoline</a></li> <li><a href="/wiki/Arazasetron" class="mw-redirect" title="Arazasetron">Arazasetron</a></li> <li><a href="/wiki/AS-8112" title="AS-8112">AS-8112</a></li> <li><a class="mw-selflink selflink">Atypical antipsychotics</a> (e.g., <a href="/wiki/Clozapine" title="Clozapine">clozapine</a>, <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a>, <a href="/wiki/Quetiapine" title="Quetiapine">quetiapine</a>)</li> <li><a href="/wiki/Azasetron" title="Azasetron">Azasetron</a></li> <li><a href="/wiki/Batanopride" title="Batanopride">Batanopride</a></li> <li><a href="/wiki/Bemesetron" title="Bemesetron">Bemesetron (MDL-72222)</a></li> <li><a href="/wiki/Bupropion" title="Bupropion">Bupropion</a></li> <li><a href="/wiki/Cilansetron" title="Cilansetron">Cilansetron</a></li> <li><a href="/wiki/CSP-2503" title="CSP-2503">CSP-2503</a></li> <li><a href="/wiki/Dazopride" title="Dazopride">Dazopride</a></li> <li><a href="/wiki/Dolasetron" title="Dolasetron">Dolasetron</a></li> <li><a href="/wiki/Galanolactone" title="Galanolactone">Galanolactone</a></li> <li><a href="/wiki/Granisetron" title="Granisetron">Granisetron</a></li> <li><a href="/wiki/Hydroxybupropion" title="Hydroxybupropion">Hydroxybupropion</a></li> <li><a href="/wiki/Lerisetron" title="Lerisetron">Lerisetron</a></li> <li><a href="/wiki/Memantine" title="Memantine">Memantine</a></li> <li><a href="/wiki/Ondansetron" title="Ondansetron">Ondansetron</a></li> <li><a href="/wiki/Palonosetron" title="Palonosetron">Palonosetron</a></li> <li><a href="/wiki/Ramosetron" title="Ramosetron">Ramosetron</a></li> <li><a href="/wiki/Renzapride" title="Renzapride">Renzapride</a></li> <li><a href="/wiki/Ricasetron" title="Ricasetron">Ricasetron</a></li> <li><a href="/wiki/Tedatioxetine" title="Tedatioxetine">Tedatioxetine</a></li> <li><a href="/wiki/Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="/wiki/Amoxapine" title="Amoxapine">amoxapine</a>, <a href="/wiki/Mianserin" title="Mianserin">mianserin</a>, <a href="/wiki/Mirtazapine" title="Mirtazapine">mirtazapine</a>)</li> <li><a href="/wiki/Thujone" title="Thujone">Thujone</a></li> <li><a href="/wiki/Tropanserin" title="Tropanserin">Tropanserin</a></li> <li><a href="/wiki/Tropisetron" title="Tropisetron">Tropisetron</a></li> <li><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="/wiki/Loxapine" title="Loxapine">loxapine</a>)</li> <li><a href="/wiki/Inhalational_anaesthetic" class="mw-redirect" title="Inhalational anaesthetic">Volatiles/gases</a> (e.g., <a href="/wiki/Nitrous_oxide" title="Nitrous oxide">nitrous oxide</a>, <a href="/wiki/Sevoflurane" title="Sevoflurane">sevoflurane</a>, <a href="/wiki/Xenon" title="Xenon">xenon</a>)</li> <li><a href="/wiki/Vortioxetine" title="Vortioxetine">Vortioxetine</a></li> <li><a href="/wiki/Zacopride" title="Zacopride">Zacopride</a></li> <li><a href="/wiki/Zatosetron" title="Zatosetron">Zatosetron</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Unknown/unsorted: <a href="/w/index.php?title=LY-53857&action=edit&redlink=1" class="new" title="LY-53857 (page does not exist)">LY-53857</a></li> <li><a href="/wiki/Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="/wiki/Naphthylpiperazine" title="Naphthylpiperazine">naphthylpiperazine</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT4_receptor" title="5-HT4 receptor">5-HT4</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a></li> <li><a href="/wiki/BIMU8" title="BIMU8">BIMU8</a></li> <li><a href="/wiki/Capeserod" title="Capeserod">Capeserod</a></li> <li><a href="/wiki/Cinitapride" title="Cinitapride">Cinitapride</a></li> <li><a href="/wiki/Cisapride" title="Cisapride">Cisapride</a></li> <li><a href="/wiki/CJ-033466" title="CJ-033466">CJ-033466</a></li> <li><a href="/wiki/Dazopride" title="Dazopride">Dazopride</a></li> <li><a href="/wiki/Metoclopramide" title="Metoclopramide">Metoclopramide</a></li> <li><a href="/w/index.php?title=Minesapride&action=edit&redlink=1" class="new" title="Minesapride (page does not exist)">Minesapride</a></li> <li><a href="/wiki/Mosapride" title="Mosapride">Mosapride</a></li> <li><a href="/wiki/Prucalopride" title="Prucalopride">Prucalopride</a></li> <li><a href="/wiki/PRX-03140" title="PRX-03140">PRX-03140</a></li> <li><a href="/wiki/Renzapride" title="Renzapride">Renzapride</a></li> <li><a href="/wiki/RS-67,333" title="RS-67,333">RS-67,333</a></li> <li><a href="/w/index.php?title=RS-67,506&action=edit&redlink=1" class="new" title="RS-67,506 (page does not exist)">RS-67,506</a></li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/Tegaserod" title="Tegaserod">Tegaserod</a></li> <li><a href="/w/index.php?title=Usmarapride&action=edit&redlink=1" class="new" title="Usmarapride (page does not exist)">Usmarapride</a></li> <li><a href="/wiki/Velusetrag" title="Velusetrag">Velusetrag</a></li> <li><a href="/wiki/Zacopride" title="Zacopride">Zacopride</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a href="/wiki/GR-113808" title="GR-113808">GR-113808</a></li> <li><a href="/w/index.php?title=GR-125487&action=edit&redlink=1" class="new" title="GR-125487 (page does not exist)">GR-125487</a></li> <li><a href="/wiki/Lysine" title="Lysine">L-Lysine</a></li> <li><a href="/wiki/Piboserod" title="Piboserod">Piboserod</a></li> <li><a href="/w/index.php?title=RS-39604&action=edit&redlink=1" class="new" title="RS-39604 (page does not exist)">RS-39604</a></li> <li><a href="/w/index.php?title=RS-67532&action=edit&redlink=1" class="new" title="RS-67532 (page does not exist)">RS-67532</a></li> <li><a href="/w/index.php?title=SB-203186&action=edit&redlink=1" class="new" title="SB-203186 (page does not exist)">SB-203186</a></li> <li><a href="/wiki/SB-204070" title="SB-204070">SB-204070</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT5A_receptor" title="5-HT5A receptor">5-HT5A</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/2-Bromo-LSD" title="2-Bromo-LSD">2-Br-LSD (BOL-148)</a>, <a href="/wiki/Ergotamine" title="Ergotamine">ergotamine</a>, <a href="/wiki/LSD" title="LSD">LSD</a>)</li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>)</li> <li><a href="/wiki/Valerenic_acid" title="Valerenic acid">Valerenic acid</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a href="/wiki/Asenapine" title="Asenapine">Asenapine</a></li> <li><a href="/wiki/Latrepirdine" title="Latrepirdine">Latrepirdine (dimebolin)</a></li> <li><a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/Ritanserin" title="Ritanserin">Ritanserin</a></li> <li><a href="/wiki/SB-699551" title="SB-699551">SB-699551</a></li></ul> <ul><li>Unknown/unsorted: <a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Metergoline" title="Metergoline">metergoline</a>, <a href="/wiki/Methysergide" title="Methysergide">methysergide</a>)</li> <li><a href="/wiki/Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="/wiki/Naphthylpiperazine" title="Naphthylpiperazine">naphthylpiperazine</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT6_receptor" title="5-HT6 receptor">5-HT6</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Dihydroergocryptine" title="Dihydroergocryptine">dihydroergocryptine</a>, <a href="/wiki/Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="/wiki/Ergotamine" title="Ergotamine">ergotamine</a>, <a href="/wiki/Lisuride" title="Lisuride">lisuride</a>, <a href="/wiki/LSD" title="LSD">LSD</a>, <a href="/wiki/Mesulergine" title="Mesulergine">mesulergine</a>, <a href="/wiki/Metergoline" title="Metergoline">metergoline</a>, <a href="/wiki/Methysergide" title="Methysergide">methysergide</a>)</li> <li><a href="/wiki/Hypidone" title="Hypidone">Hypidone</a></li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/2-Methyl-5-hydroxytryptamine" title="2-Methyl-5-hydroxytryptamine">2-Me-5-HT</a>, <a href="/wiki/5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="/wiki/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="/wiki/Bufotenin" title="Bufotenin">Bufotenin</a>, <a href="/wiki/E-6801" title="E-6801">E-6801</a>, <a href="/wiki/E-6837" title="E-6837">E-6837</a>, <a href="/wiki/EMD-386088" title="EMD-386088">EMD-386088</a>, <a href="/wiki/EMDT" title="EMDT">EMDT</a>, <a href="/w/index.php?title=LY-586713&action=edit&redlink=1" class="new" title="LY-586713 (page does not exist)">LY-586713</a>, <a href="/wiki/N-Methyl-5-HT" class="mw-redirect" title="N-Methyl-5-HT">N-Me-5-HT</a>, <a href="/wiki/ST-1936" title="ST-1936">ST-1936</a>, <a href="/wiki/Tryptamine" title="Tryptamine">tryptamine</a>)</li> <li><a href="/wiki/WAY-181187" title="WAY-181187">WAY-181187</a></li> <li><a href="/wiki/WAY-208466" title="WAY-208466">WAY-208466</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a href="/w/index.php?title=ABT-354&action=edit&redlink=1" class="new" title="ABT-354 (page does not exist)">ABT-354</a></li> <li><a class="mw-selflink selflink">Atypical antipsychotics</a> (e.g., <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="/wiki/Asenapine" title="Asenapine">asenapine</a>, <a href="/wiki/Clorotepine" title="Clorotepine">clorotepine</a>, <a href="/wiki/Clozapine" title="Clozapine">clozapine</a>, <a href="/wiki/Fluperlapine" title="Fluperlapine">fluperlapine</a>, <a href="/wiki/Iloperidone" title="Iloperidone">iloperidone</a>, <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a>, <a href="/wiki/Tiospirone" title="Tiospirone">tiospirone</a>)</li> <li><a href="/wiki/AVN-101" class="mw-redirect" title="AVN-101">AVN-101</a></li> <li><a href="/wiki/AVN-211" title="AVN-211">AVN-211</a></li> <li><a href="/wiki/AVN-322" title="AVN-322">AVN-322</a></li> <li><a href="/wiki/AVN-397" title="AVN-397">AVN-397</a></li> <li><a href="/w/index.php?title=BGC20-760&action=edit&redlink=1" class="new" title="BGC20-760 (page does not exist)">BGC20-760</a></li> <li><a href="/w/index.php?title=BVT-5182&action=edit&redlink=1" class="new" title="BVT-5182 (page does not exist)">BVT-5182</a></li> <li><a href="/w/index.php?title=BVT-74316&action=edit&redlink=1" class="new" title="BVT-74316 (page does not exist)">BVT-74316</a></li> <li><a href="/wiki/Cerlapirdine" title="Cerlapirdine">Cerlapirdine</a></li> <li><a href="/wiki/EGIS-12,233" title="EGIS-12,233">EGIS-12,233</a></li> <li><a href="/w/index.php?title=GW-742457&action=edit&redlink=1" class="new" title="GW-742457 (page does not exist)">GW-742457</a></li> <li><a href="/wiki/Idalopirdine" title="Idalopirdine">Idalopirdine</a></li> <li><a href="/wiki/Ketanserin" title="Ketanserin">Ketanserin</a></li> <li><a href="/w/index.php?title=Landipirdine&action=edit&redlink=1" class="new" title="Landipirdine (page does not exist)">Landipirdine</a></li> <li><a href="/wiki/Latrepirdine" title="Latrepirdine">Latrepirdine (dimebolin)</a></li> <li><a href="/wiki/Masupirdine" title="Masupirdine">Masupirdine</a></li> <li><a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/MS-245" title="MS-245">MS-245</a></li> <li><a href="/wiki/PRX-07034" title="PRX-07034">PRX-07034</a></li> <li><a href="/wiki/Ritanserin" title="Ritanserin">Ritanserin</a></li> <li><a href="/wiki/Ro_04-6790" title="Ro 04-6790">Ro 04-6790</a></li> <li><a href="/w/index.php?title=Ro_63-0563&action=edit&redlink=1" class="new" title="Ro 63-0563 (page does not exist)">Ro 63-0563</a></li> <li><a href="/wiki/SB-258585" title="SB-258585">SB-258585</a></li> <li><a href="/wiki/SB-271046" title="SB-271046">SB-271046</a></li> <li><a href="/wiki/SB-357134" title="SB-357134">SB-357134</a></li> <li><a href="/wiki/SB-399885" title="SB-399885">SB-399885</a></li> <li><a href="/wiki/Intepirdine" title="Intepirdine">SB-742457</a></li> <li><a href="/wiki/Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="/wiki/Amoxapine" title="Amoxapine">amoxapine</a>, <a href="/wiki/Mianserin" title="Mianserin">mianserin</a>)</li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="/wiki/Amitriptyline" title="Amitriptyline">amitriptyline</a>, <a href="/wiki/Clomipramine" title="Clomipramine">clomipramine</a>, <a href="/wiki/Doxepin" title="Doxepin">doxepin</a>, <a href="/wiki/Nortriptyline" title="Nortriptyline">nortriptyline</a>)</li> <li><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="/wiki/Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>, <a href="/wiki/Loxapine" title="Loxapine">loxapine</a>)</li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Unknown/unsorted: <a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/2-Bromo-LSD" title="2-Bromo-LSD">2-Br-LSD (BOL-148)</a>, <a href="/wiki/Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="/wiki/Lergotrile" title="Lergotrile">lergotrile</a>, <a href="/wiki/Pergolide" title="Pergolide">pergolide</a>)</li> <li><a href="/wiki/Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="/wiki/Naphthylpiperazine" title="Naphthylpiperazine">naphthylpiperazine</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">5-HT7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/8-OH-DPAT" title="8-OH-DPAT">8-OH-DPAT</a></li> <li><a href="/wiki/AS-19_(drug)" title="AS-19 (drug)">AS-19</a></li> <li><a href="/wiki/Bifeprunox" title="Bifeprunox">Bifeprunox</a></li> <li><a href="/wiki/E-55888" title="E-55888">E-55888</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/LSD" title="LSD">LSD</a>)</li> <li><a href="/wiki/LP-12" title="LP-12">LP-12</a></li> <li><a href="/wiki/LP-44" title="LP-44">LP-44</a></li> <li><a href="/wiki/LP-211" title="LP-211">LP-211</a></li> <li><a href="/wiki/RU-24,969" title="RU-24,969">RU-24,969</a></li> <li><a href="/wiki/Sarizotan" title="Sarizotan">Sarizotan</a></li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin (5-HT)</a></li> <li><a href="/wiki/Triptan" title="Triptan">Triptans</a> (e.g., <a href="/wiki/Frovatriptan" title="Frovatriptan">frovatriptan</a>)</li> <li><a href="/wiki/Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="/wiki/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="/wiki/Bufotenin" title="Bufotenin">bufotenin</a>, <a href="/wiki/N-Methylserotonin" title="N-Methylserotonin">N-Me-5-HT</a>)</li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antagonists: <a class="mw-selflink selflink">Atypical antipsychotics</a> (e.g., <a href="/wiki/Amisulpride" title="Amisulpride">amisulpride</a>, <a href="/wiki/Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="/wiki/Asenapine" title="Asenapine">asenapine</a>, <a href="/wiki/Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>, <a href="/wiki/Clorotepine" title="Clorotepine">clorotepine</a>, <a href="/wiki/Clozapine" title="Clozapine">clozapine</a>, <a href="/wiki/Fluperlapine" title="Fluperlapine">fluperlapine</a>, <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a>, <a href="/wiki/Risperidone" title="Risperidone">risperidone</a>, <a href="/wiki/Sertindole" title="Sertindole">sertindole</a>, <a href="/wiki/Tiospirone" title="Tiospirone">tiospirone</a>, <a href="/wiki/Ziprasidone" title="Ziprasidone">ziprasidone</a>, <a href="/wiki/Zotepine" title="Zotepine">zotepine</a>)</li> <li><a href="/wiki/Butaclamol" title="Butaclamol">Butaclamol</a></li> <li><a href="/wiki/DR-4485" title="DR-4485">DR-4485</a></li> <li><a href="/wiki/EGIS-12,233" title="EGIS-12,233">EGIS-12,233</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/2-Bromo-LSD" title="2-Bromo-LSD">2-Br-LSD (BOL-148)</a>, <a href="/wiki/Amesergide" title="Amesergide">amesergide</a>, <a href="/wiki/Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="/wiki/Cabergoline" title="Cabergoline">cabergoline</a>, <a href="/wiki/Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="/wiki/Ergotamine" title="Ergotamine">ergotamine</a>, <a href="/w/index.php?title=LY-53857&action=edit&redlink=1" class="new" title="LY-53857 (page does not exist)">LY-53857</a>, <a href="/wiki/LY-215,840" title="LY-215,840">LY-215,840</a>, <a href="/wiki/Mesulergine" title="Mesulergine">mesulergine</a>, <a href="/wiki/Metergoline" title="Metergoline">metergoline</a>, <a href="/wiki/Methysergide" title="Methysergide">methysergide</a>, <a href="/wiki/Sergolexole" title="Sergolexole">sergolexole</a>)</li> <li><a href="/wiki/JNJ-18038683" title="JNJ-18038683">JNJ-18038683</a></li> <li><a href="/wiki/Ketanserin" title="Ketanserin">Ketanserin</a></li> <li><a href="/wiki/LY-215,840" title="LY-215,840">LY-215,840</a></li> <li><a href="/wiki/Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li> <li><a href="/wiki/Ritanserin" title="Ritanserin">Ritanserin</a></li> <li><a href="/wiki/SB-258719" title="SB-258719">SB-258719</a></li> <li><a href="/w/index.php?title=SB-258741&action=edit&redlink=1" class="new" title="SB-258741 (page does not exist)">SB-258741</a></li> <li><a href="/wiki/SB-269970" title="SB-269970">SB-269970</a></li> <li><a href="/w/index.php?title=SB-656104&action=edit&redlink=1" class="new" title="SB-656104 (page does not exist)">SB-656104</a></li> <li><a href="/w/index.php?title=SB-656104A&action=edit&redlink=1" class="new" title="SB-656104A (page does not exist)">SB-656104A</a></li> <li><a href="/w/index.php?title=SB-691673&action=edit&redlink=1" class="new" title="SB-691673 (page does not exist)">SB-691673</a></li> <li><a href="/w/index.php?title=SLV-313&action=edit&redlink=1" class="new" title="SLV-313 (page does not exist)">SLV-313</a></li> <li><a href="/w/index.php?title=SLV-314&action=edit&redlink=1" class="new" title="SLV-314 (page does not exist)">SLV-314</a></li> <li><a href="/wiki/Spiperone" title="Spiperone">Spiperone</a></li> <li><a href="/w/index.php?title=SSR-181507&action=edit&redlink=1" class="new" title="SSR-181507 (page does not exist)">SSR-181507</a></li> <li><a href="/wiki/Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="/wiki/Amoxapine" title="Amoxapine">amoxapine</a>, <a href="/wiki/Maprotiline" title="Maprotiline">maprotiline</a>, <a href="/wiki/Mianserin" title="Mianserin">mianserin</a>, <a href="/wiki/Mirtazapine" title="Mirtazapine">mirtazapine</a>)</li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="/wiki/Amitriptyline" title="Amitriptyline">amitriptyline</a>, <a href="/wiki/Clomipramine" title="Clomipramine">clomipramine</a>, <a href="/wiki/Imipramine" title="Imipramine">imipramine</a>)</li> <li><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="/wiki/Acetophenazine" title="Acetophenazine">acetophenazine</a>, <a href="/wiki/Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>, <a href="/wiki/Chlorprothixene" title="Chlorprothixene">chlorprothixene</a>, <a href="/wiki/Fluphenazine" title="Fluphenazine">fluphenazine</a>, <a href="/wiki/Loxapine" title="Loxapine">loxapine</a>, <a href="/wiki/Pimozide" title="Pimozide">pimozide</a>)</li> <li><a href="/wiki/Vortioxetine" title="Vortioxetine">Vortioxetine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Unknown/unsorted: <a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Lisuride" title="Lisuride">lisuride</a>, <a href="/wiki/Pergolide" title="Pergolide">pergolide</a>)</li> <li><a href="/wiki/Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="/wiki/Naphthylpiperazine" title="Naphthylpiperazine">naphthylpiperazine</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li>See also: <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></li> <li><a href="/wiki/Template:Adrenergic_receptor_modulators" title="Template:Adrenergic receptor modulators">Adrenergics</a></li> <li><a href="/wiki/Template:Dopamine_receptor_modulators" title="Template:Dopamine receptor modulators">Dopaminergics</a></li> <li><a href="/wiki/Template:Melatonin_receptor_modulators" title="Template:Melatonin receptor modulators">Melatonergics</a></li> <li><a href="/wiki/Template:Monoamine_reuptake_inhibitors" title="Template:Monoamine reuptake inhibitors">Monoamine reuptake inhibitors</a> and <a href="/wiki/Template:Monoamine_releasing_agents" title="Template:Monoamine releasing agents">releasing agents</a></li> <li><a href="/wiki/Template:Monoamine_metabolism_modulators" title="Template:Monoamine metabolism modulators">Monoamine metabolism modulators</a></li> <li><a href="/wiki/Template:Monoamine_neurotoxins" class="mw-redirect" title="Template:Monoamine neurotoxins">Monoamine neurotoxins</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Atypical_antipsychotic&oldid=1282674019">https://en.wikipedia.org/w/index.php?title=Atypical_antipsychotic&oldid=1282674019</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div 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