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screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): RTIOX-276">RTIOX-276</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:RTIOX-276_Structure.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d3/RTIOX-276_Structure.svg/220px-RTIOX-276_Structure.svg.png" decoding="async" width="220" height="94" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d3/RTIOX-276_Structure.svg/330px-RTIOX-276_Structure.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d3/RTIOX-276_Structure.svg/440px-RTIOX-276_Structure.svg.png 2x" data-file-width="512" data-file-height="218" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">2-(1-(3,4-dimethoxybenzyl)-6-methoxy-7-(2,2,2-trifluoroethoxy)-3,4-dihydroisoquinolin-2(1H)-yl)-N-(pyridin-3-ylmethyl)acetamide</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/73294135">73294135</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.30820110.html">30820110</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL2418834">ChEMBL2418834</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID201336763">DTXSID201336763</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q105890687#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>29</sub><span title="Hydrogen">H</span><sub>32</sub><span title="Fluorine">F</span><sub>3</sub><span title="Nitrogen">N</span><sub>3</sub><span title="Oxygen">O</span><sub>5</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002559586000000000♠"></span>559.586</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=O%3DC%28NCC1%3DCC%3DCN%3DC1%29CN2C%28CC3%3DCC%28OC%29%3DC%28OC%29C%3DC3%29C4%3DCC%28OCC%28F%29%28F%29F%29%3DC%28OC%29C%3DC4CC2">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">O=C(NCC1=CC=CN=C1)CN2C(CC3=CC(OC)=C(OC)C=C3)C4=CC(OCC(F)(F)F)=C(OC)C=C4CC2</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C29H32F3N3O5/c1-37-24-7-6-19(12-25(24)38-2)11-23-22-14-27(40-18-29(30,31)32)26(39-3)13-21(22)8-10-35(23)17-28(36)34-16-20-5-4-9-33-15-20/h4-7,9,12-15,23H,8,10-11,16-18H2,1-3H3,(H,34,36)</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:KFNSZWWIIUHELF-UHFFFAOYSA-N</div></li></ul> </div></td></tr></tbody></table> <p><b>RTIOX-276</b> is an <a href="/wiki/Orexin_antagonist" title="Orexin antagonist">orexin antagonist</a>. RTIOX-276 binds <a href="/wiki/Binding_selectivity" title="Binding selectivity">selectively</a> to the <a href="/wiki/Orexin_1_receptor" class="mw-redirect" title="Orexin 1 receptor">orexin 1 receptor</a> (K<sub>E</sub> = 8.5nM) and lacks significant <a href="/wiki/Affinity_(pharmacology)" class="mw-redirect" title="Affinity (pharmacology)">affinity</a> for the <a href="/wiki/Orexin_2_receptor" class="mw-redirect" title="Orexin 2 receptor">orexin 2 receptor</a> (K<sub>E</sub> = > 10,000nM). RTIOX-276 may have therapeutic utility for the treatment of <a href="/wiki/Cocaine_addiction" class="mw-redirect" title="Cocaine addiction">cocaine addiction</a>. In <a href="/wiki/Conditioned_place_preference" title="Conditioned place preference">conditioned place preference</a> studies, RTIOX-276 attenuated the development of place preference in mice exposed to <a href="/wiki/Cocaine" title="Cocaine">cocaine</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RTIOX-276&action=edit&section=1" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFPerreyGermanGilmourLi2013" class="citation journal cs1">Perrey DA, German NA, Gilmour BP, Li JX, Harris DL, Thomas BF, Zhang Y (September 2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849818">"Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor"</a>. <i>Journal of Medicinal Chemistry</i>. <b>56</b> (17): 6901–16. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Fjm400720h">10.1021/jm400720h</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849818">3849818</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23941044">23941044</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Substituted+tetrahydroisoquinolines+as+selective+antagonists+for+the+orexin+1+receptor&rft.volume=56&rft.issue=17&rft.pages=6901-16&rft.date=2013-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3849818%23id-name%3DPMC&rft_id=info%3Apmid%2F23941044&rft_id=info%3Adoi%2F10.1021%2Fjm400720h&rft.aulast=Perrey&rft.aufirst=DA&rft.au=German%2C+NA&rft.au=Gilmour%2C+BP&rft.au=Li%2C+JX&rft.au=Harris%2C+DL&rft.au=Thomas%2C+BF&rft.au=Zhang%2C+Y&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3849818&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARTIOX-276" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPerreyDeckerLiGilmour2015" class="citation journal cs1">Perrey DA, Decker AM, Li JX, Gilmour BP, Thomas BF, Harris DL, et al. (September 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554834">"The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor"</a>. <i>Bioorganic & Medicinal Chemistry</i>. <b>23</b> (17): 5709–24. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bmc.2015.07.013">10.1016/j.bmc.2015.07.013</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554834">4554834</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26216017">26216017</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Bioorganic+%26+Medicinal+Chemistry&rft.atitle=The+importance+of+the+6-+and+7-positions+of+tetrahydroisoquinolines+as+selective+antagonists+for+the+orexin+1+receptor&rft.volume=23&rft.issue=17&rft.pages=5709-24&rft.date=2015-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4554834%23id-name%3DPMC&rft_id=info%3Apmid%2F26216017&rft_id=info%3Adoi%2F10.1016%2Fj.bmc.2015.07.013&rft.aulast=Perrey&rft.aufirst=DA&rft.au=Decker%2C+AM&rft.au=Li%2C+JX&rft.au=Gilmour%2C+BP&rft.au=Thomas%2C+BF&rft.au=Harris%2C+DL&rft.au=Runyon%2C+SP&rft.au=Zhang%2C+Y&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4554834&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARTIOX-276" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPerreyGermanDeckerThorn2015" class="citation journal cs1">Perrey DA, German NA, Decker AM, Thorn D, Li JX, Gilmour BP, et al. (April 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400266">"Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor"</a>. <i>ACS Chemical Neuroscience</i>. <b>6</b> (4): 599–614. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Fcn500330v">10.1021/cn500330v</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400266">4400266</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25643283">25643283</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=ACS+Chemical+Neuroscience&rft.atitle=Effect+of+1-substitution+on+tetrahydroisoquinolines+as+selective+antagonists+for+the+orexin-1+receptor&rft.volume=6&rft.issue=4&rft.pages=599-614&rft.date=2015-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4400266%23id-name%3DPMC&rft_id=info%3Apmid%2F25643283&rft_id=info%3Adoi%2F10.1021%2Fcn500330v&rft.aulast=Perrey&rft.aufirst=DA&rft.au=German%2C+NA&rft.au=Decker%2C+AM&rft.au=Thorn%2C+D&rft.au=Li%2C+JX&rft.au=Gilmour%2C+BP&rft.au=Thomas%2C+BF&rft.au=Harris%2C+DL&rft.au=Runyon%2C+SP&rft.au=Zhang%2C+Y&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4400266&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARTIOX-276" class="Z3988"></span></span> </li> </ol></div></div> <p><br /> </p> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist 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abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Orexin_receptor_modulators" title="Template:Orexin receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Orexin_receptor_modulators" title="Template talk:Orexin receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Orexin_receptor_modulators" title="Special:EditPage/Template:Orexin receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Orexin_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Orexin_receptor" title="Orexin receptor">Orexin receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Hypocretin_(orexin)_receptor_1" title="Hypocretin (orexin) receptor 1">OX<sub>1</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=AEX-5&action=edit&redlink=1" class="new" title="AEX-5 (page does not exist)">AEX-5</a></li> <li><a href="/w/index.php?title=AEX-19&action=edit&redlink=1" class="new" title="AEX-19 (page does not exist)">AEX-19</a></li> <li><a href="/w/index.php?title=AEX-24&action=edit&redlink=1" class="new" title="AEX-24 (page does not exist)">AEX-24</a></li> <li><a href="/wiki/Orexin" title="Orexin">Orexin</a> (<a href="/wiki/Orexin-A" title="Orexin-A">A</a>, <a href="/wiki/Orexin-B" class="mw-redirect" title="Orexin-B">B</a>)</li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/ACT-335827" title="ACT-335827">ACT-335827</a></li> <li><a href="/wiki/ACT-462206" title="ACT-462206">ACT-462206</a></li> <li><a href="/wiki/Almorexant" title="Almorexant">Almorexant</a></li> <li><a href="/w/index.php?title=AZD-4041&action=edit&redlink=1" class="new" title="AZD-4041 (page does not exist)">AZD-4041</a></li> <li><a href="/w/index.php?title=C4X-3256&action=edit&redlink=1" class="new" title="C4X-3256 (page does not exist)">C4X-3256 (INDV-2000)</a></li> <li><a href="/w/index.php?title=CR-5542&action=edit&redlink=1" class="new" title="CR-5542 (page does not exist)">CR-5542</a></li> <li><a href="/w/index.php?title=CVN-766&action=edit&redlink=1" class="new" title="CVN-766 (page does not exist)">CVN-766</a></li> <li><a href="/wiki/Daridorexant" title="Daridorexant">Daridorexant</a></li> <li><a href="/wiki/Fazamorexant" title="Fazamorexant">Fazamorexant (YZJ-1139)</a></li> <li><a href="/wiki/Filorexant" title="Filorexant">Filorexant</a></li> <li><a href="/wiki/GSK-649868" class="mw-redirect" title="GSK-649868">GSK-649868 (SB-649868)</a></li> <li><a href="/wiki/Lemborexant" title="Lemborexant">Lemborexant</a></li> <li><a href="/wiki/Nivasorexant" title="Nivasorexant">Nivasorexant (ACT-539313)</a></li> <li><a class="mw-selflink selflink">RTIOX-276</a></li> <li><a href="/wiki/SB-334867" title="SB-334867">SB-334867</a></li> <li><a href="/wiki/SB-408124" title="SB-408124">SB-408124</a></li> <li><a href="/wiki/Suvorexant" title="Suvorexant">Suvorexant</a></li> <li><a href="/w/index.php?title=TCS-1102&action=edit&redlink=1" class="new" title="TCS-1102 (page does not exist)">TCS-1102</a></li> <li><a href="/wiki/Tebideutorexant" title="Tebideutorexant">Tebideutorexant (JNJ-61393215)</a></li> <li><a href="/wiki/Vornorexant" title="Vornorexant">Vornorexant (ORN-0829, TS-142)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Hypocretin_(orexin)_receptor_2" title="Hypocretin (orexin) receptor 2">OX<sub>2</sub></a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=AEX-19&action=edit&redlink=1" class="new" title="AEX-19 (page does not exist)">AEX-19</a></li> <li><a href="/w/index.php?title=ALKS-2680&action=edit&redlink=1" class="new" title="ALKS-2680 (page does not exist)">ALKS-2680</a></li> <li><a href="/wiki/Danavorexton" title="Danavorexton">Danavorexton (TAK-925)</a></li> <li><a href="/w/index.php?title=E-2086&action=edit&redlink=1" class="new" title="E-2086 (page does not exist)">E-2086</a></li> <li><a href="/wiki/Firazorexton" title="Firazorexton">Firazorexton (TAK-994)</a></li> <li><a href="/wiki/Orexin" title="Orexin">Orexin</a> (<a href="/wiki/Orexin-A" title="Orexin-A">A</a>, <a href="/wiki/Orexin-B" class="mw-redirect" title="Orexin-B">B</a>)</li> <li><a href="/w/index.php?title=Oveporexton&action=edit&redlink=1" class="new" title="Oveporexton (page does not exist)">Oveporexton</a></li> <li><a href="/w/index.php?title=SB-668875&action=edit&redlink=1" class="new" title="SB-668875 (page does not exist)">SB-668875</a></li> <li><a href="/wiki/Suntinorexton" title="Suntinorexton">Suntinorexton (TAK-861)</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/ACT-335827" title="ACT-335827">ACT-335827</a></li> <li><a href="/wiki/ACT-462206" title="ACT-462206">ACT-462206</a></li> <li><a href="/wiki/Almorexant" title="Almorexant">Almorexant</a></li> <li><a href="/wiki/Daridorexant" title="Daridorexant">Daridorexant</a></li> <li><a href="/wiki/EMPA_(drug)" title="EMPA (drug)">EMPA</a></li> <li><a href="/wiki/Fazamorexant" title="Fazamorexant">Fazamorexant (YZJ-1139)</a></li> <li><a href="/wiki/Filorexant" title="Filorexant">Filorexant</a></li> <li><a href="/wiki/GSK-649868" class="mw-redirect" title="GSK-649868">GSK-649868 (SB-649868)</a></li> <li><a href="/wiki/JNJ-10397049" title="JNJ-10397049">JNJ-10397049</a></li> <li><a href="/wiki/Lemborexant" title="Lemborexant">Lemborexant</a></li> <li><a href="/w/index.php?title=MK-1064&action=edit&redlink=1" class="new" title="MK-1064 (page does not exist)">MK-1064</a></li> <li><a href="/w/index.php?title=MK-3697&action=edit&redlink=1" class="new" title="MK-3697 (page does not exist)">MK-3697</a></li> <li><a href="/w/index.php?title=MK-8133&action=edit&redlink=1" class="new" title="MK-8133 (page does not exist)">MK-8133</a></li> <li><a href="/wiki/Seltorexant" title="Seltorexant">Seltorexant</a></li> <li><a href="/wiki/Suvorexant" title="Suvorexant">Suvorexant</a></li> <li><a href="/w/index.php?title=TCS-1102&action=edit&redlink=1" class="new" title="TCS-1102 (page does not exist)">TCS-1102</a></li> <li><a href="/wiki/TCS-OX2-29" title="TCS-OX2-29">TCS-OX2-29</a></li> <li><a href="/wiki/Vornorexant" title="Vornorexant">Vornorexant (ORN-0829, TS-142)</a></li></ul> </div></td></tr></tbody></table></div> <p><br /> </p> <style 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