Performance comparison of a previously validated microhaplotype panel and a forensic STR panel for DNA mixture analysis

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class="f16">4.5</span> </span> <span class="mx-3"></span> <span class="tag">Article</span> </div> <h1 class="title title-for-article"> Performance comparison of a previously validated microhaplotype panel and a forensic STR panel for DNA mixture analysis </h1> <div class="help-links-left"> <p class="pub-info"> FORENSIC SCIENCE INTERNATIONAL-GENETICS (2025) </p> </div> </div> </div> <div id="article-sticky-navbar"> <div class="container"> <div class="d-flex justify-content-between flex-wrap flex-md-nowrap"> <div class="d-flex align-items-center mb-2"> <ul class="nav nav-underline f16 font-weight-bold"> <li class="active"> <a href="javascript:;"> Overview </a> </li> <li class=""> <a href="https://www.peeref.com/works/83533487/comments"> Write a Review </a> </li> </ul> </div> <div class="d-flex align-items-center justify-content-md-end flex-wrap flex-md-nowrap"> <div class="mr-3 mt-3 mt-md-0 flex-shrink-0"> <a href="https://doi.org/10.1016/j.fsigen.2024.103144" target="_blank" class="btn 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Microhaplotypes; STRs; Mixture analysis; Likelihood Ratio; Forensic genetics </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">Categories</h4> <div class="f16"> <span class="d-block"> <a href="https://www.peeref.com/works/list?category=Genetics+%26+Heredity" target="_blank" class="text-dark btn btn-link p-0 text-left"> Genetics & Heredity </a> </span> <span class="d-block"> <a href="https://www.peeref.com/works/list?category=Medicine%2C+Legal" target="_blank" class="text-dark btn btn-link p-0 text-left"> Medicine, Legal </a> </span> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">Funding</h4> <div class="f16"> <ol class=""> <li>Ayudas para la Formacion del Profesorado Universitario - Ministerio de Universidades from Gobierno de Espana [FPU22/02683]</li> <li>Fundacion Caixa Rural Galega Tomas Notario Vacas</li> <li>Programa de axudas a etapa predoutoral - Conselleria de Cultura, Educacion e Ordenacion Universitaria</li> <li>Conselleria de Economia, Emprego e Industria from Xunta de Galicia, Spain [ED481A-2020/039]</li> <li>Ministerio de Educacion, Cultura y Ciencia, Spain (MCIN/AEI) [PID2019-107876RB-I00]</li> <li>MCIN/AEI [PID2022-141224OB-I00]</li> <li>ERDF A way of making Europe</li> <li>Gobierno de Espana MCIN/AEI [IJC2020-042638-I]</li> <li>European Union NextGenerationEU/PRTR</li> </ol> </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 text-center">Ask authors/readers for more resources</h4> <div class="requests"> <div class="requests-item"> <div class="icon"> <img src="https://peeref-open.s3.amazonaws.com/images/file.png" alt=""> </div> <h4>Protocol</h4> <p> <a href="https://www.peeref.com/works/83533487/resource" class="btn btn-outline-primary btn-sm"> Community support </a> </p> </div> <div class="requests-item"> <div class="icon"> <img src="https://peeref-open.s3.amazonaws.com/images/experiment.png" alt=""> </div> <h4>Reagent</h4> <p> <a href="https://www.peeref.com/works/83533487/resource" class="btn btn-outline-primary btn-sm"> Community support </a> </p> </div> </div> </div> </div> <div class="col-md-8 px-0 pl-md-3"> <div id="article-summary-panel" class="mb-4"> <ul class="nav nav-tabs" style="list-style: none; padding-left: 0;"> <li class="active"> <a href="#ai_summary" data-toggle="tab" class="summary-tab mx-0 f16 text-dark"> <strong>Automated Summary</strong> <strong class="text-danger ml-1"><i>New</i></strong> </a> </li> <li class=""> <a href="#raw_abstract" data-toggle="tab" class="abstract-tab mx-0 f16 text-dark"> <strong>Abstract</strong> </a> </li> </ul> <div class="tab-content border border-top-0"> <div id="ai_summary" class="tab-pane active"> <div class="summary-panel panel-box mb-0 rounded shadow-none"> <div class="f16">This study compared the performance of microhaplotypes (MHs) and standard STR kits in forensic genetics. The MH panel performed better in detecting 2-contributor mixtures, but worse with multiple contributors. MHs had higher insertion rates and lower dropout rates, were better at recovering the alleles of the minor contributor, and provided higher LR values. The results of estimating the contributor ratio using EuroForMix were also promising. Overall, the mixture detection performance of the MH panel was better than or equal to the standard STR panel.</div> </div> </div> <div id="raw_abstract" class="tab-pane "> <div class="abstract-panel panel-box mb-0 rounded shadow-none"> <div class="f16">Short Tandem Repeats (STRs) are the most widespread markers in forensic genetics. However, STR stutter peaks can mask alleles from a minor contributor when analysing mixtures, hindering the interpretation of complex profiles. In this study we compared the performance of a previously described panel of microhaplotypes (MHs), an alternative type of forensic marker, against a standard STR kit. The parameters evaluated included: capability of determining the minimum number of contributors in the mixture; percentages of allele drop-outs and drop-ins; retrieval of alleles belonging to the minor contributor, and estimation of likelihood ratio (LR) values. In addition, the capacity of EuroForMix software to estimate each donor's percentage of contribution was tested, as well as the impact on results when using manually, or automatically prepared libraries. The MH panel showed better performance than STRs for the detection of 2-contributor mixtures, but the lower degree of polymorphism per MH marker hindered the task of deconvolution with multiple contributors. MHs presented higher drop-in rates and lower drop-out rates, a higher capability to recover the minor contributor's alleles and provided higher LR values than STRs, likely due to the much higher number of loci combined in the panel. Estimations of contributor ratios using EuroForMix showed promising results and marginal differences were found in these values between manually and automatically prepared libraries. Overall, results showed that the mixture detection performance of the MH panel was better or equal to the standard forensic autosomal STR panel, indicating microhaplotypes are informative markers for this purpose.</div> </div> </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">Authors</h4> <div class="mb-3"> <article-authors tid="83533487" list="[{"name":"J. Gonzalez-Bao","sequence":1},{"name":"A. Mosquera-Miguel","sequence":2},{"name":"L. Casanova-Adan","sequence":3},{"name":"A. Ambroa-Conde","sequence":4},{"name":"J. Ruiz-Ramirez","sequence":5},{"name":"A. Cabrejas-Olalla","sequence":6},{"name":"M. Boullon-Cassau","sequence":7},{"name":"A. Freire-Aradas","sequence":8},{"name":"A. Rodriguez-Lopez","sequence":9},{"name":"C. Roth","sequence":10},{"name":"R. Lagace","sequence":11},{"name":"C. Phillips","sequence":12},{"name":"M. V. Lareu","sequence":13},{"name":"M. de la Puente","sequence":14}]" verified="[]" page="work" ></article-authors> </div> <div class="alert alert-warning mb-0"> <h5 class="mt-0 bg-warning text-dark px-3 rounded d-inline-block"> I am an author on this paper </h5> <div class="font-weight-bold f13"> Click your name to claim this paper and add it to your profile. </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">Reviews</h4> <div class="d-flex flex-wrap flex-md-nowrap"> <div class="flex-grow-1"> <h4 class="f16"> Primary Rating <a href="javascript:;" data-toggle="tooltip" data-placement="right" title="The primary rating indicates the level of overall quality for the paper."> <i class="ivu-icon ivu-icon-md-help-circle f18 ml-2"></i> </a> </h4> <div class="d-flex flex-wrap flex-md-nowrap align-items-center alert mb-0"> <div class="d-flex align-items-center justify-content-center"> <Rate disabled allow-half value="4.5" style="font-size: 28px;"></Rate> <strong class="f20 m-3" style="color: #f5a623;">4.5</strong> </div> <div class="text-muted mx-4"> Not enough ratings </div> </div> <h4 class="f16"> Secondary Ratings <a href="javascript:;" data-toggle="tooltip" data-placement="right" title="Secondary ratings independently reflect strengths or weaknesses of the paper."> <i class="ivu-icon ivu-icon-md-help-circle f18 ml-2"></i> </a> </h4> <div class="d-flex flex-wrap flex-md-nowrap alert"> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">Novelty</h5> <strong class="mx-4">-</strong> </div> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">Significance</h5> <strong class="mx-4">-</strong> </div> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">Scientific rigor</h5> <strong class="mx-4">-</strong> </div> </div> </div> <div class="flex-shrink-0"> <div class="border bg-light py-2 px-4"> <h5 class="mb-1">Rate this paper</h5> <Rate class="f24" @on-change="function(value){ location.href='https://www.peeref.com/works/83533487/comments?rating='+value }"></Rate> </div> </div> </div> </div> <div id="collection" class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">Recommended</h4> <div class="my-3"> <ul class="nav nav-pills border-bottom pb-3" style="list-style: none; padding-left: 0;"> <li class="active"> <a href="#articles_from_related" data-toggle="tab" class="mx-0 f15"> <strong>Related</strong> </a> </li> <li class=""> <a href="#articles_from_authors" data-toggle="tab" class="mx-0 f15"> <strong>From Same Authors</strong> </a> </li> <li class=""> <a href="#articles_from_journal" data-toggle="tab" class="mx-0 f15"> <strong>From Same Journal</strong> </a> </li> </ul> <div class="tab-content"> <div id="articles_from_related" class="tab-pane active"> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/81627176" class="text-dark hover-underline">MHBase: A comprehensive database of short microhaplotypes for advancing forensic genetic analysis</a> </h4> <p class="text-ellipsis-2">Jiaming Xue, Mengyu Tan, Qiushuo Wu, Yazi Zheng, Guihong Liu, Ranran Zhang, Dezhi Chen, Yuanyuan Xiao, Miao Liao, Meli Lv, Shengqiu Qu, Weibo Liang, Lin Zhang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/2908.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This article introduces the advantages of microhaplotypes (MHs) in forensic applications and two databases, ALFRED and MicroHapDB, as well as the SNP-SNP MH database (D-SNPsDB) within 50bp of the whole human genome that we constructed. On this basis, we further constructed a more comprehensive database and established a user-friendly website that allows users to search the database to find suitable loci and provides other functions. This website is a useful tool for researchers. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/81627176/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Food Science & Technology </span> </div> <h4> <a href="https://www.peeref.com/works/82931435" class="text-dark hover-underline">Pairwise kinship inference and pedigree reconstruction using 91 microhaplotypes</a> </h4> <p class="text-ellipsis-2">Yifan Wei, Qiang Zhu, Haoyu Wang, Yueyan Cao, Xi Li, Xiaokang Zhang, Yufang Wang, Ji Zhang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/2886.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study addresses the issue of kinship inference when there are no prior assumptions and the relationships between multiple individuals are unknown. It uses genotyping and likelihood ratio calculation to infer relatedness and reconstruct pedigrees. The results show that 91 microhaplotypes can discriminate second-degree relatives from unrelated individuals, and more loci are needed to distinguish more distant relatives. Correct classification can be achieved by expanding the suspected relationships. This study provides a new solution for kinship inference. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FOOD AND CHEMICAL TOXICOLOGY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/82931435/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Medicine, Legal </span> </div> <h4> <a href="https://www.peeref.com/works/21759274" class="text-dark hover-underline">Evaluation of microhaplotypes in forensic kinship analysis from a Swedish population perspective</a> </h4> <p class="text-ellipsis-2">Adam Staadig, Andreas Tillmar</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/3787.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study evaluated the performance of a custom-made microhaplotype panel in Swedish samples, demonstrating its sensitivity in detecting haplotypes, mixture samples, and kinship relationships. Despite some primer design issues, the technology shows promise for further implementation in the forensic field. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">INTERNATIONAL JOURNAL OF LEGAL MEDICINE</span> (2021) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/21759274/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/28382357" class="text-dark hover-underline">Molecular diversity of 23-YSTR markers in Iraqi populations</a> </h4> <p class="text-ellipsis-2">Mohammed Mahdi Al-Zubaidi, Majeed Arsheed Sabbah, Hanan Khaleel Mahmood</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/2998.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study aimed to analyze the distribution of Y chromosome haplotypes in native Iraqi males and compare it with neighboring Arab populations. The results showed high genetic diversity in the Iraqi population, with the most common haplogroups being J1 and J2. This study provides valuable reference data for the Iraqi database. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">GENE</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/28382357/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/25558075" class="text-dark hover-underline">State of the Art for Microhaplotypes</a> </h4> <p class="text-ellipsis-2">Kenneth K. Kidd, Andrew J. Pakstis</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/9770.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> In recent years, there has been a significant increase in the number of publications on microhaplotypes, which have proven to be highly informative in various areas of forensic DNA analysis. Microhaplotypes can be measured using different indicators and have important applications in parentage testing and missing persons cases. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">GENES</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/25558075/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/82936722" class="text-dark hover-underline">Pairwise kinship inference and pedigree reconstruction using 91 microhaplotypes</a> </h4> <p class="text-ellipsis-2">Yifan Wei, Qiang Zhu, Haoyu Wang, Yueyan Cao, Xi Li, Xiaokang Zhang, Yufang Wang, Ji Zhang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/2908.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study solves the problem of kinship inference without prior assumptions by genotyping and calculating the likelihood ratio to infer the relatedness of individuals. It is found that increasing the number of polymorphic loci can improve the accuracy of kinship inference, and correct classification can be achieved by expanding the suspected relationship. In addition, this method can also be used to reconstruct the pedigree of multiple individuals with unknown relationships. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/82936722/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/28820037" class="text-dark hover-underline">Genetic Polymorphism Analysis of 24 Y-STRs in a Han Chinese Population in Luzhou, Southwest China</a> </h4> <p class="text-ellipsis-2">Jiewen Fu, Binghui Song, Jie Qian, Ting He, Hanchun Chen, Jingliang Cheng, Junjiang Fu</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/9770.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study analyzed the Y-STRs genetic data of male individuals from the Han population in Luzhou, demonstrating high polymorphism. Comparisons with 11 other related Han populations revealed close genetic relationships between Luzhou Han people and Han populations in Sichuan, Guangdong, and Hunan, consistent with geographical distribution, historical influence, and economic development. These findings are of great value for forensic applications and population genetics research. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">GENES</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/28820037/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Multidisciplinary Sciences </span> </div> <h4> <a href="https://www.peeref.com/works/26052839" class="text-dark hover-underline">Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy</a> </h4> <p class="text-ellipsis-2">Mayra M. Banuelos, Yuomi Jhony A. Zavaleta, Alennie Roldan, Rochelle-Jan Reyes, Miguel Guardado, Berenice Chavez Rojas, Thet Nyein, Ana Rodriguez Vega, Maribel Santos, Emilia Huerta-Sanchez, Rori V. Rohlfs</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/6895.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study reveals significant correlations between forensic STRs and neighboring gene expression levels, suggesting that forensic genetic loci may reveal expression levels and potential medical information. These findings have important implications for criminal investigations and genomic research. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/26052839/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry & Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/82066705" class="text-dark hover-underline">Analysis of 26 STR loci (PowerPlex® Fusion 6C System) in a mestizo population from Mexico city</a> </h4> <p class="text-ellipsis-2">Mauro Lopez-Armenta, Maria Elizbeth Alvarez-Sanchez, Carolina Leon-Campos, Blanca Zoila Gonzalez-Sobrino, Hector Rangel-Villalobos, Jose Francisco Munoz-Valle, Astrid Desiree Sanchez-Mendez, Jose Alonso Aguilar-Velazquez</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/5943.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study genotyped 600 DNA samples from Mexico City using the PowerPlex Fusion 6C System, which includes 26 STRs. The results demonstrated the efficacy of this system for human identification in the studied population and its potential application in other Mexican Mestizo populations. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">MOLECULAR BIOLOGY REPORTS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/82066705/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Medicine, Legal </span> </div> <h4> <a href="https://www.peeref.com/works/24649754" class="text-dark hover-underline">An overview of SNP-SNP microhaplotypes in the 26 populations of the 1000 Genomes Project</a> </h4> <p class="text-ellipsis-2">Jiaming Xue, Shengqiu Qu, Mengyu Tan, Yuanyuan Xiao, Ranran Zhang, Dezhi Chen, Meili Lv, Yiming Zhang, Lin Zhang, Weibo Liang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/3787.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Microhaplotypes (MHs) are a promising new type of forensic markers that have advantages such as low mutation rates, lack of stutter artifacts, and short amplicons. They have improved human identification, kinship analysis, ancestry prediction, and mixture deconvolution capabilities. While there are some public databases available for MHs, there is a need for a more comprehensive database that integrates information from other databases. This study successfully established a dual-SNP MH database (D-SNPsDB) for 26 populations, providing basic data such as physical positions, allele frequencies, and variant information. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">INTERNATIONAL JOURNAL OF LEGAL MEDICINE</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/24649754/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/24053401" class="text-dark hover-underline">Twenty-Seven Y-Chromosome Short Tandem Repeats Analysis of Italian Mummies of the 16th and 18th Centuries: An Interdisciplinary Research</a> </h4> <p class="text-ellipsis-2">Carla Bini, Elisabetta Cilli, Stefania Sarno, Mirko Traversari, Francesco Fontani, Alessio Boattini, Susi Pelotti, Donata Luiselli</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/10211.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Roccapelago is a small village in the Northern Central Apennines with a population genetic isolate, where a diachronic study of DNA was conducted to investigate the structure and dynamics of the population over centuries. The study found the utility of Y chromosome in identifying historically relevant remains and discovering patterns of relatedness in communities, transitioning from anthropology to genetic genealogy and forensics. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FRONTIERS IN GENETICS</span> (2021) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/24053401/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Anthropology </span> </div> <h4> <a href="https://www.peeref.com/works/23288079" class="text-dark hover-underline">Genetic analysis of sixteen autosomal STR loci in three Tunisian populations from Makthar, Nabeul and Sousse</a> </h4> <p class="text-ellipsis-2">Rim Al-Haj-Taib, Abir Mejri, Claus Borsting, Vania Pereira, Sarra Elkamel, Rene J. Herrera, Amel Benammar-Elgaaied, Karima Fadhlaoui-Zid</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/611.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study estimated the genetic diversity and structure of three Tunisian populations using autosomal STRs. The results showed that these populations have genetic affinity with geographically close populations. There were no genetic differences between the Tunisian populations, but significant variance was observed within the same group, indicating heterogeneity. The application of autosomal STRs in anthropological and forensic studies is strongly supported by the results. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANNALS OF HUMAN BIOLOGY</span> (2021) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/23288079/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/27322032" class="text-dark hover-underline">FST estimates of 94 populations in China based on STR markers</a> </h4> <p class="text-ellipsis-2">Xuan Dai, Qiang Zhu, Chu Wang, Aosiman Rukeye, Ze Cao, Tiantian Shan, Yufang Wang, Ji Zhang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/2908.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> The proper assessment of DNA evidence in personal identification cases is important in forensics. The likelihood ratio (LR) is commonly used to evaluate the strength of DNA evidence. Accurate use of population allele frequencies is a crucial factor in LR calculation. FST values can estimate allele frequency differences among different populations and affect LR values when correcting allele frequencies. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/27322032/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Medicine, Legal </span> </div> <h4> <a href="https://www.peeref.com/works/23486326" class="text-dark hover-underline">19th century family saga re-told by DNA recovered from postcard stamps</a> </h4> <p class="text-ellipsis-2">Cordula Haas, Christian Koerner, Andrea Sulzer, Adelgunde Kratzer</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/2907.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> By analyzing ancient DNA from pre-war postage stamps, a family saga was unraveled, proving that an illegitimate child was actually the legitimate child of a married couple. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/23486326/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biotechnology & Applied Microbiology </span> </div> <h4> <a href="https://www.peeref.com/works/26430890" class="text-dark hover-underline">Population genetic study of 17 Y-STR Loci of the Sorani Kurds in the Province of Sulaymaniyah, Iraq</a> </h4> <p class="text-ellipsis-2">Balnd M. Albarzinji, Farhad M. Abdulkarim, Shaho A. Hussein, Dlshad Rashid, Hayder Lazim</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/1255.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study investigates the population relationship of the Sorani Kurdish population in Sulaymaniyah province using DNA samples. The results show that the J2 subclade predominates in this population, and they cluster with Asian populations while being furthest from European and African populations. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BMC GENOMICS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/26430890/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> </div> <div id="articles_from_authors" class="tab-pane "> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/28372708" class="text-dark hover-underline">Development of an epigenetic age predictor for costal cartilage with a simultaneous somatic tissue differentiation system</a> </h4> <p class="text-ellipsis-2">A. Freire-Aradas, M. Tomsia, D. Piniewska-Rog, A. Ambroa-Conde, M. A. Casares de Cal, A. Pisareke, A. Gomez-Tato, J. Alvarez-Diosf, E. Pospiech, W. Parson, M. Kayser, C. Phillips, W. Branicki</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Age prediction from DNA has become a significant research topic, and the use of epigenetic markers has shown promising results. In this study, a cartilage age prediction model based on methylation data was developed using the VISAGE Enhanced Tool. Additionally, a tissue prediction model was created, which can accurately differentiate blood, buccal cells, bone, and cartilage. The development of these models significantly expands the use of the VISAGE Enhanced Tool and increases the amount of DNA methylation-based information obtained from forensic analysis. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/28372708/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/28372733" class="text-dark hover-underline">Adapting an established Ampliseq microhaplotype panel to nanopore sequencing through direct PCR</a> </h4> <p class="text-ellipsis-2">L. Casanova-Adan, A. Mosquera-Miguel, J. Gonzalez-Bao, A. Ambroa-Conde, J. Ruiz-Ramirez, A. Cabrejas-Olalla, E. Gonzalez-Martin, A. Freire-Aradas, A. Rodriguez-Lopez, C. Phillips, Mv Lareu, M. de la Puente</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> We have successfully adapted the Ampliseq microhaplotype panel for forensic genetics applications using the Oxford Nanopore Technologies system. Our cost-effective and highly scalable solution combines direct PCR amplification with ONT library construction and sequencing. The results demonstrate stable coverage patterns, allele balance, and strand bias, achieving high profile completeness and concordance rates. The nanopore workflow also shows improved forensic utility compared to traditional methods. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/28372733/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/24609577" class="text-dark hover-underline">Combining current knowledge on DNA methylation-based age estimation towards the development of a superior forensic DNA intelligence tool</a> </h4> <p class="text-ellipsis-2">Anastasia Aliferi, Sudha Sundaram, David Ballard, Ana Freire-Aradas, Christopher Phillips, Maria Victoria Lareu, Denise Syndercombe Court</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study introduces a DNA methylation-based age estimation method for blood that shows high accuracy and sensitivity. By analyzing and validating data from a large number of individuals, a set of 11 markers with potential for accurate age estimation from minimal DNA material was identified. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/24609577/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/24609582" class="text-dark hover-underline">A collaborative exercise on DNA methylation-based age prediction and body fluid typing</a> </h4> <p class="text-ellipsis-2">Ji Eun Lee, Jeong Min Lee, Jana Naue, Jan Fleckhaus, Ana Freire-Aradas, Jacqueline Neubauer, Ewelina Pospiech, Bruce McCord, Vivian Kalamara, Quentin Gauthier, Carly Mills, Yijian Cao, Zheng Wang, Yu Na Oh, Lei Feng, Peter M. Schneider, Christopher Phillips, Cordula Haas, Aleksandra Pisarek, Wojciech Branicki, Daniele Podini, Athina Vidaki, Nicole Fernandez Tejero, Adrian Ambroa-Conde, Ana Mosquera-Miguel, Maria Victoria Lareu, Yiping Hou, Joo Young Lee, Hwan Young Lee</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> DNA methylation has become an important biomarker for age prediction and body fluid identification in forensic science. SNaPshot-based assays, with their multiplex analysis capability and compatibility with existing instrumentation, show great potential for forensic laboratories. However, technical validation is necessary for successful integration into routine workflows. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/24609582/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/25877831" class="text-dark hover-underline">Eurasiaplex-2: Shifting the focus to SNPs with high population specificity increases the power of forensic ancestry marker sets</a> </h4> <p class="text-ellipsis-2">C. Phillips, M. de la Puente, J. Ruiz-Ramirez, A. Staniewska, A. Ambroa-Conde, A. Freire-Aradas, A. Mosquera-Miguel, A. Rodriguez, M. V. Lareu</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Researchers developed a new South Asian-informative panel for forensic ancestry SNP analysis. They selected 120 candidate SNPs with near absolute specificity and finally chose a panel of 36 SNPs with different allele frequencies in South Asian populations. Consistent patterns of allele frequency distribution specific to South Asia were observed in global population data. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/25877831/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/25877832" class="text-dark hover-underline">Epigenetic age estimation in saliva and in buccal cells</a> </h4> <p class="text-ellipsis-2">A. Ambroa-Conde, L. Giron-Santamaria, A. Mosquera-Miguel, C. Phillips, M. A. Casares de Cal, A. Gomez-Tato, J. Alvarez-Dios, M. de la Puente, J. Ruiz-Ramirez, M. Lareu, A. Freire-Aradas</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Age estimation based on epigenetic markers is a potential DNA intelligence tool that can provide relevant information for criminal investigations. This study developed age prediction models based on different tissues and validated their accuracy. The models can improve the inference of age-dependent physical characteristics and help determine the origin of samples in criminal investigations. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/25877832/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/25877834" class="text-dark hover-underline">Development and inter-laboratory evaluation of the VISAGE Enhanced Tool for Appearance and Ancestry inference from DNA</a> </h4> <p class="text-ellipsis-2">C. Xavier, M. de la Puente, A. Mosquera-Miguel, A. Freire-Aradas, V. Kalamara, A. Ralf, A. Revoir, T. E. Gross, P. M. Schneider, C. Ames, C. Hohoff, C. Phillips, M. Kayser, W. Parson</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> The VISAGE Consortium was founded in 2017 to develop new molecular and statistical tools for predicting appearance, ancestry, and age from DNA. The VISAGE Enhanced Tool for Appearance and Ancestry, the first forensic-driven genetic laboratory tool, includes markers for eye, hair, and skin color, as well as more recently discovered markers for other traits. Five VISAGE laboratories tested and evaluated the tool, and it was found to be robust, reproducible, and sensitive. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/25877834/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/25877846" class="text-dark hover-underline">A common epigenetic clock from childhood to old age</a> </h4> <p class="text-ellipsis-2">A. Freire-Aradas, L. Giron-Santamaria, A. Mosquera-Miguel, A. Ambroa-Conde, C. Phillips, M. Casares de Cal, A. Gomez-Tato, J. Alvarez-Dios, E. Pospiech, A. Aliferi, D. Syndercombe Court, W. Branicki, M. V. Lareu</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Forensic age estimation is an important DNA intelligence tool for criminal cases, human identification analysis, and anthropological studies. This study presents a DNA methylation-based age prediction model with high accuracy using quantile regression statistical methods. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/25877846/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/22903058" class="text-dark hover-underline">Development and Evaluation of the Ancestry Informative Marker Panel of the VISAGE Basic Tool</a> </h4> <p class="text-ellipsis-2">Maria de la Puente, Jorge Ruiz-Ramirez, Adrian Ambroa-Conde, Catarina Xavier, Jacobo Pardo-Seco, Jose Alvarez-Dios, Ana Freire-Aradas, Ana Mosquera-Miguel, Theresa E. Gross, Elaine Y. Y. Cheung, Wojciech Branicki, Michael Nothnagel, Walther Parson, Peter M. Schneider, Manfred Kayser, Angel Carracedo, Maria Victoria Lareu, Christopher Phillips</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> The VISAGE Basic Tool developed an ancestry informative SNP panel by combining 41 appearance predictive SNPs and 112 ancestry predictive SNPs. This panel showed good sequencing performance and can effectively differentiate individuals from different continental population groups, including individuals from South Asia. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">GENES</span> (2021) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/22903058/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Cell Biology </span> </div> <h4> <a href="https://www.peeref.com/works/36360316" class="text-dark hover-underline">Development of the VISAGE enhanced tool and statistical models for epigenetic age estimation in blood, buccal cells and bones</a> </h4> <p class="text-ellipsis-2">Anna Wozniak, Antonia Heidegger, Danuta Piniewska-Rog, Ewelina Pospiech, Catarina Xavier, Aleksandra Pisarek, Ewa Kartasinska, Michal Boron, Ana Freire-Aradas, Marta Wojtas, Maria de la Puente, Harald Niederstaetter, Rafal Ploski, Magdalena Spolnicka, Manfred Kayser, Christopher Phillips, Walther Parson, Wojciech Branicki</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> The study presents an enhanced tool for DNA methylation age estimation in somatic tissues, utilizing a sensitive multiplex MPS assay for accurate age prediction with small DNA samples. The tool is tailored to blood, buccal cells, and bones, achieving mean absolute errors of 3.2, 3.7, and 3.4 years, respectively. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">AGING-US</span> (2021) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/36360316/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Multidisciplinary Sciences </span> </div> <h4> <a href="https://www.peeref.com/works/23932377" class="text-dark hover-underline">Evaluation of a custom QIAseq targeted DNA panel with 164 ancestry informative markers sequenced with the Illumina MiSeq</a> </h4> <p class="text-ellipsis-2">D. Truelsen, A. Freire-Aradas, M. Nazari, A. Aliferi, D. Ballard, C. Phillips, N. Morling, V Pereira, C. Borsting</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> The introduction of new methods in forensic genetic case work requires meticulous evaluation. The QIAseq Targeted DNA panel showed good consistency and reproducibility under different DNA input conditions, but issues were found when the input was low. Different mixture ratios in mixtures can impact the analysis results. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">SCIENTIFIC REPORTS</span> (2021) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/23932377/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/20984651" class="text-dark hover-underline">Development and validation of the VISAGE AmpliSeq basic tool to predict appearance and ancestry from DNA</a> </h4> <p class="text-ellipsis-2">Catarina Xavier, Maria de la Puente, Ana Mosquera-Miguel, Ana Freire-Aradas, Vivian Kalamara, Athina Vidaki, Theresa E. Gross, Andrew Revoir, Ewelina Pospiech, Ewa Kartasinska, Magdalena Spolnicka, Wojciech Branicki, Carole E. Ames, Peter M. Schneider, Carsten Hohoff, Manfred Kayser, Christopher Phillips, Walther Parson</p> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2020) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/20984651/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/21241691" class="text-dark hover-underline">A Comparison of Forensic Age Prediction Models Using Data From Four DNA Methylation Technologies</a> </h4> <p class="text-ellipsis-2">A. Freire-Aradas, E. Pospiech, A. Aliferi, L. Giron-Santamaria, A. Mosquera-Miguel, A. Pisarek, A. Ambroa-Conde, C. Phillips, M. A. Casares de Cal, A. Gomez-Tato, M. Spolnicka, A. Wozniak, J. alvarez-Dios, D. Ballard, D. Syndercombe Court, W. Branicki, Angel Carracedo, M. V. Lareu</p> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FRONTIERS IN GENETICS</span> (2020) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/21241691/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> </div> <div id="articles_from_journal" class="tab-pane "> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83039808" class="text-dark hover-underline">Application of a newly constructed NGS panel with 45 X-linked microhaplotypes demonstrates the unique value of X-MH for kinship testing and mixture analysis</a> </h4> <p class="text-ellipsis-2">Guanju Ma, Kailiang Liu, Chaolong Lu, Qingqing Du, Mengjie Zhang, Qian Wang, Guangping Fu, Junyan Wang, Chunling Ma, Bin Cong, Shujin Li, Lihong Fu</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study screened 63 X-MHs, evaluated their performance, and calculated population parameters. The panel performed well in personal identification and paternity testing, and showed unique advantages in complex kinship and male DNA mixture analyses. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83039808/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83225861" class="text-dark hover-underline">Profiling age and body fluid DNA methylation markers using nanopore adaptive sampling</a> </h4> <p class="text-ellipsis-2">Zaka Wing-Sze Yuen, Somasundhari Shanmuganandam, Maurice Stanley, Simon Jiang, Nadine Hein, Runa Daniel, Dennis McNevin, Cameron Jack, Eduardo Eyras</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> DNA methylation plays a crucial role in physiological processes and can be used as a biomarker for body fluid identification and age prediction. Current methylation detection methods rely on various techniques and markers, requiring specialized DNA preparation and biochemical treatments. This study used nanopore adaptive sampling technology to simultaneously identify age-associated and body fluid-specific methylation markers without the need for specialized DNA preparation or biochemical treatments. The technology was consistent with whole-genome bisulfite sequencing data and identified new sites strongly correlated with age. This study lays the foundation for the development of nanopore-based methods for age prediction and body fluid identification. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83225861/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83112863" class="text-dark hover-underline">Improved individual identification in DNA mixtures of unrelated or related contributors through massively parallel sequencing</a> </h4> <p class="text-ellipsis-2">Zhiyong Liu, Enlin Wu, Ran Li, Jiajun Liu, Yu Zang, Bin Cong, Riga Wu, Bo Xie, Hongyu Sun</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study evaluated the impact of potential kinship on individual identification, including MPS performance, the influence of genetic markers on kinship and NOC inference, the probability distribution of MAC and TAC, trends in LR values, and comparisons of length- and sequence-based STR genotypes. Results showed that multiple genetic markers improved the accuracy of kinship and NOC inference, the LR value of the POI depended on the mixing ratio, and the correct kinship hypothesis yielded more conservative LR values. In addition, using sequence-based STR genotypes increased the power of individual identification and the accuracy of mixture ratio inference. The MGIEasy Signature Identification Library Prep kit demonstrated robust individual identification capabilities and is suitable for forensic DNA mixture interpretation. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83112863/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83547292" class="text-dark hover-underline">Forensic efficiency evaluation of a mtDNA whole genome sequencing system constructed with long fragment amplification strategy on DNA nanoball sequencing platform</a> </h4> <p class="text-ellipsis-2">Man Chen, Chong Chen, Ning Li, Yuerong Su, Wei Cui, Yan Huang, Meiming Cai, Bofeng Zhu</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study evaluated a novel mtDNA whole genome sequencing system using long fragment amplification strategy on the DNA nanoball sequencing platform. The system demonstrated high sequencing quality and specific mtDNA sequencing efficiencies on positive control DNA and FTA bloodstain samples. In addition, the system sequencing efficiency was also confirmed among different kinds of samples. In summary, the system showed high performance in analyzing mtDNA sequence information, and had great prospects in forensic application and maternal genetic research. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83547292/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83094956" class="text-dark hover-underline">Sequencing-induced artefacts in NGS STR data</a> </h4> <p class="text-ellipsis-2">Yao-Yuan Liu, Kevin Cheng, Rebecca Just, Sana Enke, Jo-Anne Bright</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This paper mainly introduces the high-read count noise sequences observed in the analysis of DNA profiles using the MiSeq FGx sequencing system, as well as the characteristics and causes of these noise sequences. The authors also introduce the methods used to detect these noise sequences and the help these methods provide to the laboratory. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83094956/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83110084" class="text-dark hover-underline">Shedding more light on shedders</a> </h4> <p class="text-ellipsis-2">Piyamas Petcharoen, Madison Nolan, K. Paul Kirkbride, Adrian Linacre</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study tested 100 individuals to demonstrate the reproducibility of the cell staining process in a large population. The results showed that 98 donors had consistent and reproducible cell number deposition, with no difference between the left and right thumbs, and more cells deposited by males than females. The study also suggested that shedder status may be a continuum phenomenon. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83110084/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83010213" class="text-dark hover-underline">Saliva-derived secondary DNA transfer on fabric: The impact of varying conditions</a> </h4> <p class="text-ellipsis-2">Melanie S. Gegar, German A. Cisneros, Joanne Cox, Melanie Richard, Krista A. Currie</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study investigated the secondary DNA transfer of saliva on different fabrics, including the effects of saliva moisture, contact methods, and other factors on DNA transfer. The study found that nylon fabric is more likely to transfer DNA than cotton and towel fabric, and wet saliva is more likely to transfer DNA than dry and rehydrated saliva. Active pressure is more likely to transfer DNA than controlled pressure. In addition, the study found that in some cases, the amount of DNA transferred to the secondary fabric is sufficient for STR-PCR amplification. These findings help us better understand the mechanism of DNA transfer and provide useful information for forensic science and criminal investigations. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83010213/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83645405" class="text-dark hover-underline">Rapid detection of blood using a novel application of RT-RPA integrated with CRISPR-Cas: ALAS2 detection as a model</a> </h4> <p class="text-ellipsis-2">Chih-Wen Su, Yi-Che Hsu, Li-Chin Tsai, James Chun- Lee, Adrian Linacre, Hsing-Mei Hsieh</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> A blood test method based on recombinase polymerase amplification, CRISPR-Cas, and lateral flow assay is reported, which is rapid, sensitive, and specific, and can detect the ALAS2 marker in blood. The test can use extracted RNA or directly added body fluids as templates, with a low detection limit, and can only detect blood, not other body fluids. When peripheral blood is mixed with saliva or semen, the test results will be affected. This method is expected to be applied in places far from the laboratory, such as crime scenes. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83645405/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/82908069" class="text-dark hover-underline">Unique molecular identifier-based amplicon sequencing of microhaplotypes for background noise mitigation</a> </h4> <p class="text-ellipsis-2">Ye-Lim Kwon, Kyoung-Jin Shin</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study designed a UMI-based amplicon sequencing system, MH-UMIseq, which can simultaneously amplify 46 MHs and generate MPS libraries in four steps. The performance of the system was evaluated using Illumina NextSeq 550 and MiniSeq systems, and the results showed that the system can significantly suppress background noise, and the proportion of unsuppressed noise decreased significantly with the increase of input DNA. Therefore, the resolution of the MH-UMIseq system is expected to be higher than that of traditional MPS. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/82908069/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/82936722" class="text-dark hover-underline">Pairwise kinship inference and pedigree reconstruction using 91 microhaplotypes</a> </h4> <p class="text-ellipsis-2">Yifan Wei, Qiang Zhu, Haoyu Wang, Yueyan Cao, Xi Li, Xiaokang Zhang, Yufang Wang, Ji Zhang</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study solves the problem of kinship inference without prior assumptions by genotyping and calculating the likelihood ratio to infer the relatedness of individuals. It is found that increasing the number of polymorphic loci can improve the accuracy of kinship inference, and correct classification can be achieved by expanding the suspected relationship. In addition, this method can also be used to reconstruct the pedigree of multiple individuals with unknown relationships. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/82936722/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83140740" class="text-dark hover-underline">A novel type of three band pattern at STR loci</a> </h4> <p class="text-ellipsis-2">B. Rolf, A. Phillip, K. Hannig, S. Koehler, I. Goettesdorfer</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> SE33 or ACTBP2 is the most polymorphic locus in many national DNA databases and commercial STR kits. This article describes the molecular reason for the three-band pattern of SE33, which is caused by the SNP in the flanking SE33 region that leads to the binding of the unlabeled D3S1358 primer, generating a chimeric PCR product smaller than the regular SE33 amplicon. This three-band pattern is called Type 3, and its genetic basis is different from Type 1 and Type 2. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83140740/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83347599" class="text-dark hover-underline">'Low' LRs obtained from DNA mixtures: On calibration and discrimination performance of probabilistic genotyping software</a> </h4> <p class="text-ellipsis-2">M. McCarthy-Allen, O. Bleka, R. Ypma, P. Gill, C. Benschop</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study evaluated the performance of various PG software in the low LR range using the PROVEDIt dataset and found that previously reported LR thresholds may be too high, suggesting that they be lowered or discarded. The study also emphasizes the importance of calibration metrics in understanding the performance of PG systems. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83347599/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83754813" class="text-dark hover-underline">Comprehensive body fluid identification and contributor assignment by combining targeted sequencing of mRNA and coding region SNPs</a> </h4> <p class="text-ellipsis-2">Maximilian Neis, Theresa Gross, Harald Schneider, Peter M. Schneider, Cornelius Courts</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This article describes the development of an mRNA/cSNP panel for forensic genetic analysis, which can provide crucial contextualizing information on the source level about a trace's composition and reduce the risk of association fallacies by typing individual coding region SNPs. The panel has high reliable detection sensitivity and low RNA input, and further optimization and improvement are needed in the future. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83754813/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/83775519" class="text-dark hover-underline">A multiplex microbial profiling system for the identification of the source of body fluid and skin samples</a> </h4> <p class="text-ellipsis-2">Hewen Yao, Yanyun Wang, Shuangshuang Wang, Chaoran Sun, Yuxiang Zhou, Lanrui Jiang, Zefei Wang, Xindi Wang, Zhirui Zhang, Tingting Yang, Feng Song, Haibo Luo</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> In this study, a multiplex system with seven microbial markers was developed to distinguish between skin, saliva, and feces samples. The system accurately identified sample types by generating specific electropherograms and was further tested and classified by beta diversity analysis and skin microenvironment cluster analysis. In addition, a machine learning prediction model was established to identify the skin microenvironment with an accuracy of 79%. These findings provide new insights into the application of microbial markers in forensic science. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83775519/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Genetics & Heredity </span> </div> <h4> <a href="https://www.peeref.com/works/27322024" class="text-dark hover-underline">Kinship analysis of skeletal remains from the Middle Ages</a> </h4> <p class="text-ellipsis-2">Mirela Dzehverovic, Belma Jusic, Amela Pilav, Tamara Lukic, Jasmina Cakar</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Medieval cemeteries in Travnik, Bosnia and Herzegovina were excavated from 2011 to 2014, revealing skeletal remains of 11 individuals. Genetic analysis was conducted on these remains to test familial relationships and predict Y-haplogroup. Autosomal and Y-STR markers were analyzed, and kinship analysis showed direct brother-brother relatives with a high probability. Y-STR profiles indicated the same paternal lineage and J2a haplogroup for all male individuals. This study highlights the importance of utilizing STR markers and additional markers like Y-STRs in archaeogenetic studies to obtain comprehensive information on relatives and ancestry. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FORENSIC SCIENCE INTERNATIONAL-GENETICS</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/27322024/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="modal fade" id="export-citation" tabindex="-1"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal"><span>×</span></button> <h4 class="modal-title">Export Citation <b class="text-primary"></b></h4> </div> <div class="modal-body"> <div class="my-3 px-4 f16"> <form 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Performance comparison of a previously validated microhaplotype panel and a forensic STR panel for DNA mixture analysis - Peeref