Magic™ Membrane Protein Human ERBB3 (Erb-b2 receptor tyrosine kinase 3, transcript variant 1) expressed in Sf9 for Antibody Discovery

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The protein is for research use only and is not approved for use in humans or in clinical diagnosis. </div> <h2 class="proshow-list-specifications-tit"><i class="fa fa-align-right"></i>Product Specifications</h2> <div class="proshow-list-specifications"> <ul> <li>Host Species</li> <li>Human</li> </ul> <ul> <li>Target Protein</li> <li>ERBB3</li> </ul> <ul> <li>Protein Length</li> <li>Full-length</li> </ul> <ul> <li>Protein Class</li> <li>Adult stem cells, Druggable Genome, Protein Kinase, Secreted Protein, Stem cell - Pluripotency, Transmembrane</li> </ul> <ul> <li>Molecular Weight</li> <li>148.1 kDa</li> </ul> <ul> <li>TMD</li> <li>1</li> </ul> <ul> <li>Sequence</li> <li>MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT</li> </ul> </div> <h2 class="proshow-list-specifications-tit"><i class="fa fa-align-right"></i>Product Description</h2> <div class="proshow-list-specifications"> <ul> <li>Expression Systems</li> <li>Sf9</li> </ul> <ul> <li>Tag</li> <li>C-DDK</li> </ul> <ul> <li>Purity</li> <li>> 80% as determined by SDS-PAGE and Coomassie blue staining</li> </ul> <ul> <li>Buffer</li> <li>50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol</li> </ul> </div> <h2 class="proshow-list-specifications-tit"><i class="fa fa-align-right"></i>Target</h2> <div class="proshow-list-specifications"> <ul> <li>Target Protein</li> <li>ERBB3</li> </ul> <ul> <li>Full Name</li> <li>Erb-b2 receptor tyrosine kinase 3</li> </ul> <ul> <li>Introduction</li> <li>This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.</li> </ul> <ul> <li>Alternative Names</li> <li>c-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK; HER3; LCCS2; MDA-BF-1; p45 sErbB3; p85-sErbB3; p180-ErbB3; human epidermal growth factor receptor 3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; Receptor tyrosine-protein kinase erbB-3</li> </ul> <ul> <li>Gene ID</li> <li><a href="http://www.ncbi.nlm.nih.gov/gene/2065">2065</a></li> </ul> <ul> <li>UniProt ID</li> <li><a href="http://www.uniprot.org/uniprot/P21860">P21860</a></li> </ul> </div> <h2 class="proshow-list-specifications-tit tab_q_c"> <i class="fa fa-exclamation-circle"></i>Customer reviews and Q&As     <a href="form/review.aspx?title=%255BMP0080Q%255D%2520Magic%25E2%2584%25A2%2520Membrane%2520Protein%2520Human%2520ERBB3%2520(Erb-b2%2520receptor%2520tyrosine%2520kinase%25203%252C%2520transcript%2520variant%25201)%2520expressed%2520in%2520Sf9%2520for%2520Antibody%2520Discovery&type=review" class="signup" style="font-size: 14px;" target="_blank">Write a review</a> <a href="form/review.aspx?title=%255BMP0080Q%255D%2520Magic%25E2%2584%25A2%2520Membrane%2520Protein%2520Human%2520ERBB3%2520(Erb-b2%2520receptor%2520tyrosine%2520kinase%25203%252C%2520transcript%2520variant%25201)%2520expressed%2520in%2520Sf9%2520for%2520Antibody%2520Discovery&type=question" class="signup" target="_blank" style="font-size: 14px;">Ask a question</a> </h2> <b class="proshow-list-specifications-tit"><i class="fa fa-dice-d6"></i>Related Products</b> <div class="proshow-list-specifications"> <ul> <li><a 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