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(medicina)</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Ir a un artículo en otro idioma. Disponible en 23 idiomas" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-23" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">23 idiomas</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AA%D8%B5%D9%81%D9%8A%D8%A9_(%D8%B7%D8%A8)" title="تصفية (طب) (árabe)" lang="ar" hreflang="ar" data-title="تصفية (طب)" data-language-autonym="العربية" data-language-local-name="árabe" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Klirens_(farmakologija)" title="Klirens (farmakologija) (bosnio)" lang="bs" hreflang="bs" data-title="Klirens (farmakologija)" data-language-autonym="Bosanski" data-language-local-name="bosnio" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Clearance" title="Clearance (checo)" lang="cs" hreflang="cs" data-title="Clearance" data-language-autonym="Čeština" data-language-local-name="checo" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Renale_Clearance" title="Renale Clearance (alemán)" lang="de" hreflang="de" data-title="Renale Clearance" data-language-autonym="Deutsch" data-language-local-name="alemán" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Clearance_(medicine)" title="Clearance (medicine) (inglés)" lang="en" hreflang="en" data-title="Clearance (medicine)" data-language-autonym="English" data-language-local-name="inglés" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%A9%D9%84%DB%8C%D8%B1%D8%A7%D9%86%D8%B3" title="کلیرانس (persa)" lang="fa" hreflang="fa" data-title="کلیرانس" data-language-autonym="فارسی" data-language-local-name="persa" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Puhdistuma" title="Puhdistuma (finés)" lang="fi" hreflang="fi" data-title="Puhdistuma" data-language-autonym="Suomi" data-language-local-name="finés" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Clairance_(biologie)" title="Clairance (biologie) (francés)" lang="fr" hreflang="fr" data-title="Clairance (biologie)" data-language-autonym="Français" data-language-local-name="francés" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Laju_ekskresi_renal" title="Laju ekskresi renal (indonesio)" lang="id" hreflang="id" data-title="Laju ekskresi renal" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonesio" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Clearance" title="Clearance (italiano)" lang="it" hreflang="it" data-title="Clearance" data-language-autonym="Italiano" data-language-local-name="italiano" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%AF%E3%83%AA%E3%82%A2%E3%83%A9%E3%83%B3%E3%82%B9_(%E5%8C%BB%E5%AD%A6)" title="クリアランス (医学) (japonés)" lang="ja" hreflang="ja" data-title="クリアランス (医学)" data-language-autonym="日本語" data-language-local-name="japonés" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%B2%AD%EC%86%8C%EC%9C%A8_(%EC%95%BD%EB%A6%AC%ED%95%99)" title="청소율 (약리학) (coreano)" lang="ko" hreflang="ko" data-title="청소율 (약리학)" data-language-autonym="한국어" data-language-local-name="coreano" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Klaring_(medisch)" title="Klaring (medisch) (neerlandés)" lang="nl" hreflang="nl" data-title="Klaring (medisch)" data-language-autonym="Nederlands" data-language-local-name="neerlandés" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Clearance" title="Clearance (noruego bokmal)" lang="nb" hreflang="nb" data-title="Clearance" data-language-autonym="Norsk bokmål" data-language-local-name="noruego bokmal" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Klirens" title="Klirens (polaco)" lang="pl" hreflang="pl" data-title="Klirens" data-language-autonym="Polski" data-language-local-name="polaco" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Depura%C3%A7%C3%A3o_plasm%C3%A1tica" title="Depuração plasmática (portugués)" lang="pt" hreflang="pt" data-title="Depuração plasmática" data-language-autonym="Português" 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id="mw-content-subtitle"><div class="cdx-message cdx-message--block cdx-message--warning mw-revision"><span class="cdx-message__icon"></span><div class="cdx-message__content"><div id="mw-revision-info"><div style="background: #FFBDBD; border: 1px solid #BB7979; color: #000000; font-weight: bold; margin: 2em 0 .5em; padding: .5em 1em; vertical-align: middle; clear: both;">Esta es una <a href="/wiki/Ayuda:Historial" title="Ayuda:Historial">versión antigua</a> de esta página, editada a las <span id="mw-revision-date">17:49 24 ago 2010</span> por <span id="mw-revision-name"><a href="/wiki/Usuario:Jorge_c2010" class="mw-userlink" title="Usuario:Jorge c2010" data-mw-revid="39731868"><bdi>Jorge c2010</bdi></a> <span class="mw-usertoollinks">(<a href="/wiki/Usuario_discusi%C3%B3n:Jorge_c2010" class="mw-usertoollinks-talk" title="Usuario discusión:Jorge c2010">discusión</a> · <a href="/wiki/Especial:Contribuciones/Jorge_c2010" class="mw-usertoollinks-contribs" title="Especial:Contribuciones/Jorge c2010">contribs.</a>)</span></span>. La dirección URL es un <a href="/wiki/Ayuda:Enlace_permanente" title="Ayuda:Enlace permanente">enlace permanente</a> a esta versión, que puede ser diferente de la <span class="plainlinks"><a class="external text" href="https://es.wikipedia.org/wiki/Depuraci%C3%B3n_(medicina)">versión actual</a></span>.</div> <div id="viewingold-plain" style="display:none;">Versión a fecha de 17:49 24 ago 2010, por <a href="/wiki/Usuario:Jorge_c2010" class="mw-userlink" title="Usuario:Jorge c2010" data-mw-revid="39731868"><bdi>Jorge c2010</bdi></a> <span class="mw-usertoollinks">(<a href="/wiki/Usuario_discusi%C3%B3n:Jorge_c2010" class="mw-usertoollinks-talk" title="Usuario discusión:Jorge c2010">discusión</a> · <a href="/wiki/Especial:Contribuciones/Jorge_c2010" class="mw-usertoollinks-contribs" title="Especial:Contribuciones/Jorge c2010">contribs.</a>)</span></div></div><div id="mw-revision-nav">(<a href="/w/index.php?title=Depuraci%C3%B3n_(medicina)&diff=prev&oldid=39731868" title="Depuración (medicina)">difs.</a>) <a href="/w/index.php?title=Depuraci%C3%B3n_(medicina)&direction=prev&oldid=39731868" title="Depuración (medicina)">← Revisión anterior</a> · <a href="/wiki/Depuraci%C3%B3n_(medicina)" title="Depuración (medicina)">Ver revisión actual</a> (<a href="/w/index.php?title=Depuraci%C3%B3n_(medicina)&diff=cur&oldid=39731868" title="Depuración (medicina)">difs.</a>) · <a href="/w/index.php?title=Depuraci%C3%B3n_(medicina)&direction=next&oldid=39731868" title="Depuración (medicina)">Revisión siguiente →</a> (<a href="/w/index.php?title=Depuraci%C3%B3n_(medicina)&diff=next&oldid=39731868" title="Depuración (medicina)">difs.</a>)</div></div></div></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="es" dir="ltr"><p>En <a href="/wiki/Medicina" title="Medicina">medicina</a>, la <b>depuración</b>, <b>separación</b>, o <b>aclaramiento</b> (<b>CL</b>, del inglés <i>clearance</i>) de una sustancia es el inverso del <a href="/w/index.php?title=Tiempo_constante&action=edit&redlink=1" class="new" title="Tiempo constante (aún no redactado)">tiempo constante</a> que describe su índice de <a href="/wiki/Eliminaci%C3%B3n_(farmacolog%C3%ADa)" title="Eliminación (farmacología)">eliminación</a> del cuerpo dividido por su <a href="/wiki/Volumen_de_distribuci%C3%B3n" title="Volumen de distribución">volumen de distribución</a> (o total de agua corporal). </p><p>El aclaramiento, puede determinarse de una forma global (<b>aclaramiento sistémico</b>) o de forma individualizada para cada vía (<b>aclaramiento hepático</b>, <b>renal</b>, etc.). La ecuación que recoge este concepto sería: </p> <center><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle CL_{o}=Q\cdot {\frac {(C_{A}-C_{V})}{C_{A}}}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>C</mi> <msub> <mi>L</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>o</mi> </mrow> </msub> <mo>=</mo> <mi>Q</mi> <mo>⋅</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mo stretchy="false">(</mo> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> <mo>−</mo> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>V</mi> </mrow> </msub> <mo stretchy="false">)</mo> </mrow> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> </mfrac> </mrow> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle CL_{o}=Q\cdot {\frac {(C_{A}-C_{V})}{C_{A}}}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/77554cc17fcf60661e32b24c6f922f3e02795cf6" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -2.338ex; width:22.765ex; height:6.176ex;" alt="{\displaystyle CL_{o}=Q\cdot {\frac {(C_{A}-C_{V})}{C_{A}}}}"></span></center> <p>En donde <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle CL_{o}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>C</mi> <msub> <mi>L</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>o</mi> </mrow> </msub> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle CL_{o}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/a52068c3a8754a168fad0b6f4c012e82c82e7285" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:4.379ex; height:2.509ex;" alt="{\displaystyle CL_{o}}"></span> es el aclaramiento del órgano, <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle C_{A}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle C_{A}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/69c5f6fde0832b5aa24cc8d90aca913e132e9929" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:3.127ex; height:2.509ex;" alt="{\displaystyle C_{A}}"></span> la concentración plasmática en sangre arterial, <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle C_{A}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle C_{A}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/69c5f6fde0832b5aa24cc8d90aca913e132e9929" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:3.127ex; height:2.509ex;" alt="{\displaystyle C_{A}}"></span> la concentración plasmática en sangre venosa y <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle Q}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>Q</mi> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle Q}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/8752c7023b4b3286800fe3238271bbca681219ed" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:1.838ex; height:2.509ex;" alt="{\displaystyle Q}"></span> el flujo sanguíneo del órgano. </p><p>Es usado en el área de <a href="/wiki/Farmacolog%C3%ADa" title="Farmacología">farmacología</a>, para referirse a la capacidad que tiene un órgano para eliminar un <a href="/wiki/F%C3%A1rmaco" title="Fármaco">fármaco</a>. Se expresa mediante el número de mililitros de <a href="/wiki/Plasma_sangu%C3%ADneo" class="mw-redirect" title="Plasma sanguíneo">plasma</a> que se depura de una sustancia (<a href="/wiki/F%C3%A1rmaco" title="Fármaco">fármaco</a>) determinada por minuto. La expulsión del fármaco puede ser consecuencia de procesos que tienen lugar en <a href="/wiki/Ri%C3%B1%C3%B3n" title="Riñón">riñones</a>, <a href="/wiki/H%C3%ADgado" title="Hígado">hígado</a> y otros órganos. </p><p>El <a href="/wiki/Aclaramiento_renal" title="Aclaramiento renal">aclaramiento renal</a> es usado también para evaluar algunos aspectos de la función renal. </p>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Obtenido de «<a dir="ltr" href="https://es.wikipedia.org/w/index.php?title=Depuración_(medicina)&oldid=39731868">https://es.wikipedia.org/w/index.php?title=Depuración_(medicina)&oldid=39731868</a>»</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Especial:Categor%C3%ADas" title="Especial:Categorías">Categorías</a>: <ul><li><a href="/wiki/Categor%C3%ADa:Farmacocin%C3%A9tica" title="Categoría:Farmacocinética">Farmacocinética</a></li><li><a href="/wiki/Categor%C3%ADa:Fisiolog%C3%ADa_humana" title="Categoría:Fisiología humana">Fisiología humana</a></li><li><a href="/wiki/Categor%C3%ADa:Nefrolog%C3%ADa" title="Categoría:Nefrología">Nefrología</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> Esta página se editó por última vez el 24 ago 2010 a las 17:49.</li> <li id="footer-info-copyright">El texto está disponible bajo la <a href="/wiki/Wikipedia:Texto_de_la_Licencia_Creative_Commons_Atribuci%C3%B3n-CompartirIgual_4.0_Internacional" title="Wikipedia:Texto de la Licencia Creative Commons Atribución-CompartirIgual 4.0 Internacional">Licencia Creative Commons Atribución-CompartirIgual 4.0</a>; pueden aplicarse cláusulas adicionales. 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