Premade Single Domain Antibody (SdAb) Library Licensing Service

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We are happy to leverage our unparalleled library resources and extensive expertise to assist our clients with their sdAb discovery and development projects. </p> <p> Single domain antibodies, derived from camelid species, represent a special type of antibody consisting of a single monomeric variable antibody domain. With a molecular weight of only 12-15 kDa, single domain antibodies are much smaller than common antibodies (150-160 kDa). Therefore, single domain antibodies combine the benefits of conventional antibodies with important features of small molecule drugs, gaining increasing attention in biological drug development field in recent years. </p> <p> <strong>Advantages of Single Domain Antibodies:</strong> </p> <ul class="ullist disc"> <li> Better solubility </li> <li> Able to bind to hidden epitopes that are not accessible to whole antibodies </li> <li> Greater affinity and selectivity, thus promising lower side effect and better efficacy </li> <li> Penetrate tissues faster than other antibodies, and even break through the blood-brain barrier </li> <li> Higher stability to changes in temperature and chemical environments, greater potential of gastrointestinal stability and oral availability </li> <li> Exceptional drug format flexibility and allow efficient drug discovery and development </li> </ul> <p> Currently, there are following premade sdAb libraries in Creative Biolabs available for licensing: </p> <p> <strong>CaV<sub>H</sub>HL-1: Camel Naïve Single Domain Antibody Library</strong> </p> <ol class="ollist decimal"> <li> Phagemid phage display system </li> <li> M13 pIII fusion containing 6×His and c-Myc detection tag </li> <li> V<sub>H</sub>H antibody genes from camel PBMCs </li> <li> Capacity: 1.5×10<sup>9</sup> </li> <li> Proliferation in TG1 cells </li> <li> Production of soluble antibody fragments in HB2151 </li> <li> Helper phage M13KO7 </li> </ol> <br /> <p> <strong>LlaV<sub>H</sub>HL-1: Llama Naïve Single Domain Antibody Library</strong> </p> <ol class="ollist decimal"> <li> Phagemid phage display system </li> <li> M13 pIII fusion containing 6×His and c-Myc detection tag </li> <li> V<sub>H</sub>H antibody genes from llama lymphocytes </li> <li> Capacity: 2.0×10<sup>9</sup> </li> <li> Proliferation in TG1 cells </li> <li> Production of soluble antibody fragments in HB2151 </li> <li> Helper phage M13KO7 </li> </ol> <br /> <p> Furthermore, we also provide<strong> Premade SdAb Library Screening</strong> service to identify specific binders for different kinds of targets from the above libraries and the following two libraries. </p> <p> <strong>CaV<sub>H</sub>HL-3: Camel Naïve Single Domain Antibody Library</strong> </p> <ol class="ollist decimal"> <li> Phagemid phage display system </li> <li> M13 pIII fusion containing 6×His and c-Myc detection tag </li> <li> V<sub>H</sub>H antibody genes from camel PBMCs </li> <li> Capacity: 3.0×10<sup>9</sup> </li> <li> Proliferation in TG1 cells </li> <li> Production of soluble antibody fragments in HB2151 </li> <li> Helper phage M13KO7 </li> </ol> <br /> <p> <strong>CaV<sub>H</sub>HL-4: Camel Naïve Single Domain Antibody Library</strong> </p> <ol class="ollist decimal"> <li> Phagemid phage display system </li> <li> M13 pIII fusion containing 6×His and c-Myc detection tag </li> <li> V<sub>H</sub>H antibody genes from camel lymphocytes </li> <li> Capacity: 2.63×10<sup>10</sup> </li> <li> Proliferation in TG1 cells </li> <li> Production of soluble antibody fragments in HB2151 </li> <li> Helper phage M13KO7 </li> </ol> <br /> <p> <strong>CaV<sub>H</sub>HL-5: Camel Naïve Single Domain Antibody Library </strong> </p> <ol class="ollist decimal"> <li> Phagemid phage display system </li> <li> M13 pIII fusion containing HA and 6xHis detection tag </li> <li> V<sub>H</sub>H antibody genes from camel lymphocytes </li> <li> Capacity: 3.0×10<sup>10</sup> </li> <li> Proliferation in TG1 cells </li> <li> Production of soluble antibody fragments in HB2151 </li> <li> Helper phage M13KO7 </li> </ol> <br /> <p> <strong>V<sub>H</sub>HL-S1: Llama Synthetic Single Domain Antibody Library </strong> </p> <ol class="ollist decimal"> <li> Phagemid phage display system </li> <li> M13 pIII fusion containing short HA and 6xHis detection tag </li> <li> V<sub>H</sub>H format </li> <li> Introduced synthetic trimer-codon HCDR1, HCDR2 and HCDR3 </li> <li> Capacity: 1.0×10<sup>11</sup> </li> <li> Proliferation in TG1 cells </li> <li> Production of soluble antibody fragments in HB2151 </li> <li> Helper phage M13KO7 </li> </ol> <br /> <p> <strong>V<sub>H</sub>HL-S2: Camel Synthetic Single Domain Antibody Library </strong> </p> <ol class="ollist decimal"> <li> Phagemid phage display system </li> <li> M13 pIII fusion containing short HA and 6xHis detection tag </li> <li> V<sub>H</sub>H format </li> <li> Introduced synthetic trimer-codon HCDR1, HCDR2 and HCDR3 </li> <li> Capacity: 5.4×10<sup>10</sup> </li> <li> Proliferation in TG1 cells </li> <li> Production of soluble antibody fragments in HB2151 </li> <li> Helper phage M13KO7 </li> </ol> <br /> <p> <strong>V<sub>H</sub>HL-S3: Camel Synthetic Single Domain Antibody Library</strong> </p> <ol class="ollist decimal"> <li> Phagemid phage display system </li> <li> M13 pIII fusion containing 6xHis detection tag </li> <li> V<sub>H</sub>H format </li> <li> Introduced synthetic trimer-codon HCDR3 </li> <li> Capacity: 2.2×10<sup>10</sup> </li> <li> Proliferation in TG1 cells </li> <li> Production of soluble antibody fragments in HB2151 </li> <li> Helper phage M13KO7 </li> </ol> <br /> <p> <strong>V<sub>H</sub>HL-S4: Camel Semi-synthetic Single Domain Antibody Library</strong> </p> <ol class="ollist decimal"> <li> Phagemid phage display system </li> <li> M13 pIII fusion containing short HA and 6xHis detection tag </li> <li> V<sub>H</sub>H format </li> <li> Introduced synthetic trimer-codon HCDR3 in naïve V<sub>H</sub>H gene pool (lacking HCDR3) </li> <li> Capacity: 5.3×10<sup>10</sup> </li> <li> Proliferation in TG1 cells </li> <li> Production of soluble antibody fragments in HB2151 </li> <li> Helper phage M13KO7 </li> </ol> <br /> <p> In addition, we are also happy to tailor custom-oriented services of sdAb library construction with different of strategies, such as NNK/NNS, trimer codon, and then perform library screening against a variety of targets from them. Our tech staffs are ready 24/7 to discuss with your every specific project. Please feel free to <a href="/Premade-single-domain-antibody-library.html#OnlineInquiry" rel="nofollow">inquire us</a> for more information. </p><br> <p class="pronote"><i class="fa fa-exclamation-triangle"></i>All listed services and products are For Research Use Only. 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