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<!doctype html> <html data-n-head-ssr lang="en" data-n-head="%7B%22lang%22:%7B%22ssr%22:%22en%22%7D%7D"> <head > <link data-n-head="ssr" rel="icon" type="image/png" sizes="16x16" href="https://brand.frontiersin.org/m/ed3f9ce840a03d7/favicon_16-tenantFavicon-Frontiers.png"> <link data-n-head="ssr" rel="icon" type="image/png" sizes="32x32" href="https://brand.frontiersin.org/m/ed3f9ce840a03d7/favicon_32-tenantFavicon-Frontiers.png"> <link data-n-head="ssr" rel="apple-touch-icon" type="image/png" sizes="180x180" href="https://brand.frontiersin.org/m/ed3f9ce840a03d7/favicon_180-tenantFavicon-Frontiers.png"> <title>Frontiers | Editorial: Systems biology approaches to psychiatric and psychological disorders: unraveling the complexities</title><meta data-n-head="ssr" charset="utf-8"><meta data-n-head="ssr" name="viewport" content="width=device-width, initial-scale=1"><meta data-n-head="ssr" data-hid="charset" charset="utf-8"><meta data-n-head="ssr" data-hid="mobile-web-app-capable" name="mobile-web-app-capable" content="yes"><meta data-n-head="ssr" data-hid="apple-mobile-web-app-title" name="apple-mobile-web-app-title" content="Frontiers | Articles"><meta data-n-head="ssr" data-hid="theme-color" name="theme-color" content="#0C4DED"><meta data-n-head="ssr" data-hid="description" property="description" name="description" content="One central theme in this Research Topic is the role of metabolites as intermediaries of trauma response. Gary et al. highlighted dysregulated pathways in ac..."><meta data-n-head="ssr" data-hid="og:title" property="og:title" name="title" content="Frontiers | Editorial: Systems biology approaches to psychiatric and psychological disorders: unraveling the complexities"><meta data-n-head="ssr" data-hid="og:description" property="og:description" name="description" content="One central theme in this Research Topic is the role of metabolites as intermediaries of trauma response. Gary et al. highlighted dysregulated pathways in ac..."><meta data-n-head="ssr" data-hid="keywords" name="keywords" content="biomarker,computational biology,systems biology,psychological disorders,molecular assay"><meta data-n-head="ssr" data-hid="og:site_name" property="og:site_name" name="site_name" content="Frontiers"><meta data-n-head="ssr" data-hid="og:image" property="og:image" name="image" content="https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/12AFEC62-10F2-4A9B-900C8422E4B53D54/511D4207-6085-4D24-9E5E56EBCA9EBCD2/WebsiteWebP_XL-FGENE_Main Visual_Purple_Website.webp"><meta data-n-head="ssr" data-hid="og:type" property="og:type" name="type" content="article"><meta data-n-head="ssr" data-hid="og:url" property="og:url" name="url" content="https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1547943/full"><meta data-n-head="ssr" data-hid="twitter:card" name="twitter:card" content="summary_large_image"><meta data-n-head="ssr" data-hid="citation_volume" name="citation_volume" content="16"><meta data-n-head="ssr" data-hid="citation_journal_title" name="citation_journal_title" content="Frontiers in Genetics"><meta data-n-head="ssr" data-hid="citation_publisher" name="citation_publisher" content="Frontiers"><meta data-n-head="ssr" data-hid="citation_journal_abbrev" name="citation_journal_abbrev" content="Front. Genet."><meta data-n-head="ssr" data-hid="citation_issn" name="citation_issn" content="1664-8021"><meta data-n-head="ssr" data-hid="citation_doi" name="citation_doi" content="10.3389/fgene.2025.1547943"><meta data-n-head="ssr" data-hid="citation_firstpage" name="citation_firstpage" content="1547943"><meta data-n-head="ssr" data-hid="citation_language" name="citation_language" content="English"><meta data-n-head="ssr" data-hid="citation_title" name="citation_title" content="Editorial: Systems biology approaches to psychiatric and psychological disorders: unraveling the complexities"><meta data-n-head="ssr" data-hid="citation_keywords" name="citation_keywords" content="biomarker; computational biology; systems biology; psychological disorders; molecular assay"><meta data-n-head="ssr" data-hid="citation_abstract" name="citation_abstract" content="One central theme in this Research Topic is the role of metabolites as intermediaries of trauma response. Gary et al. highlighted dysregulated pathways in acute stress disorder (ASD), including amino acid metabolism and lipid signaling, revealing potential metabolic biomarkers for early diagnosis and intervention (Gary, Misganaw et al. 2024). Similarly, Patel et al. examined how dietary polyunsaturated fatty acids (PUFAs) modulate neuronal resilience to traumatic brain injury (TBI) and stress, implicating diet as a critical factor in mitigating visual and neuronal deficits (Patel, Yang et al. 2024). Transcriptomic analyses showed that DHA-enriched diets activate pathways such as SNARE signaling, endocannabinoid synapse pathways, and synaptic long-term depression, while suppressing inflammatory cytokine signaling (e.g., IL-6, IL-8) and ferroptosis, underscoring the interaction between PUFA treatment, TBI, and brain signaling networks. These findings emphasize the need to consider both endogenous and environmental influences in understanding stress resilience and vulnerability.Another key focus is the gut-brain axis and its role in stress and mood disorders. Chakraborty et al. reviewed how microbial metabolites mediate the host&#39;s response to environmental stressors, suggesting a bidirectional relationship influencing neuroinflammation and behavior (Chakraborty 2024). Furthering our understanding of the gut-brain axis in the context of mental health, Pinakhina et al. investigated the intronic variant rs521851 in the MAGI2 (S-SCAM) gene significantly associated with depression symptoms in individuals with a high risk of eating disorders, highlighting its influence on gut-brain axis dysregulation (Pinakhina, Kasyanov et al.). Their results underscore the genetic underpinnings of psychiatric conditions and reinforce the interplay between genetic predisposition and environmental stressors. Such insights underscore the potential of targeting microbiome-related pathways and considering genetic factors in addressing trauma-related disorders.Beyond the gut-brain axis, researchers also employed cutting-edge tools to investigate the complexities of stress response systems. Parker et al. employed neural ordinary differential equations (NODEs) to model the hypothalamic-pituitary-adrenal (HPA) axis dynamics, offering a machine-learning-based framework to predict stress responses in depressive disorders (Parker, Nelson et al. 2024). This innovative approach highlights the growing importance of integrating computational models with biological data to enhance diagnostic accuracy and therapeutic precision.In summary, this Research Topic underscores the complexity and interconnectedness of molecular systems in trauma and stress responses. By fostering interdisciplinary collaboration and innovative methodologies, these studies pave the way for more holistic approaches to understanding and mitigating the impacts of trauma on health. "><meta data-n-head="ssr" data-hid="citation_pdf_url" name="citation_pdf_url" content="https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1547943/pdf"><meta data-n-head="ssr" data-hid="citation_online_date" name="citation_online_date" content="2025/01/06"><meta data-n-head="ssr" data-hid="citation_publication_date" name="citation_publication_date" content="2025/01/28"><meta data-n-head="ssr" data-hid="citation_author_0" name="citation_author" content="Yang, Ruoting"><meta data-n-head="ssr" data-hid="citation_author_institution_0" name="citation_author_institution" content="Medical Readiness Systems Biology, United States"><meta data-n-head="ssr" data-hid="citation_author_1" name="citation_author" content="Daigle, Bernie J."><meta data-n-head="ssr" data-hid="citation_author_institution_1" name="citation_author_institution" content="Departments of Biological Sciences and Computer Science, United States"><meta data-n-head="ssr" data-hid="citation_author_2" name="citation_author" content="Rampersaud, Ryan"><meta data-n-head="ssr" data-hid="citation_author_institution_2" name="citation_author_institution" content="Department of Psychiatry and Behavioral Sciences, United States"><meta data-n-head="ssr" data-hid="citation_author_3" name="citation_author" content="Schultebraucks, Katharina"><meta data-n-head="ssr" data-hid="citation_author_institution_3" name="citation_author_institution" content="Department of Psychiatry, United States"><meta data-n-head="ssr" data-hid="dc.identifier" name="dc.identifier" content="doi:10.3389/fgene.2025.1547943"><link data-n-head="ssr" rel="manifest" href="/article-pages/_nuxt/manifest.c499fc0a.json" data-hid="manifest"><link data-n-head="ssr" rel="canonical" href="https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1547943/full"><script data-n-head="ssr" data-hid="newrelic-browser-script" type="text/javascript">window.NREUM||(NREUM={});NREUM.info = {"agent":"","beacon":"bam.nr-data.net","errorBeacon":"bam.nr-data.net","licenseKey":"598a124f17","applicationID":"588603994","agentToken":null,"applicationTime":1.670025,"transactionName":"MQcDMkECCkNSW0YMWghNIgldDQFTRxd1IGFJTQ==","queueTime":0,"ttGuid":"51191f86dd914f1c"}; (window.NREUM||(NREUM={})).init={privacy:{cookies_enabled:true},ajax:{deny_list:["bam.nr-data.net"]},distributed_tracing:{enabled:true}};(window.NREUM||(NREUM={})).loader_config={agentID:"594400880",accountID:"230385",trustKey:"230385",xpid:"VgUHUl5WGwYIXFdSBAgOUg==",licenseKey:"598a124f17",applicationID:"588603994"};;/*! 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class="ArticleDetailsEditors__editors"><div class="ArticleDetailsEditors__title">Edited by</div> <a href="https://loop.frontiersin.org/people/555998/overview" data-event="editorInfo-a-roseannEPeterson" class="ArticleDetailsEditors__ediorInfo"><figure class="Avatar Avatar--size-32"><img src="https://loop.frontiersin.org/images/profile/555998/32" alt="Roseann E Peterson" class="Avatar__img is-inside-mask"></figure> <div class="ArticleDetailsEditors__ediorInfo__info"><div class="ArticleDetailsEditors__ediorInfo__name notranslate"> Roseann E Peterson </div> <div class="ArticleDetailsEditors__ediorInfo__affiliation notranslate"> </div></div></a></div></div>  <div class="ArticleDetailsGlossary ArticleDetailsGlossary--open"><button class="ArticleDetailsGlossary__header"><div class="ArticleDetailsGlossary__header__title">Table of contents</div> <div class="ArticleDetailsGlossary__header__arrow"></div></button> <div class="ArticleDetailsGlossary__content"><ul class="flyoutJournal"><li><a 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Genet.</span><span>, 28 January 2025</span></div> <div class="ArticleLayoutHeader__info__journalDate"> Sec. Behavioral and Psychiatric Genetics </div> <div class="ArticleLayoutHeader__info__doiVolume"><span> Volume 16 - 2025 | </span> <a href="https://doi.org/10.3389/fgene.2025.1547943" class="ArticleLayoutHeader__info__doi"> https://doi.org/10.3389/fgene.2025.1547943 </a></div> </div>  <div class="ArticleLayoutHeader__isPartOfRT"><span class="ArticleLayoutHeader__isPartOfRT__label">This article is part of the Research Topic</span> <span class="ArticleLayoutHeader__isPartOfRT__title">Systems Biology Approaches to Psychiatric and Psychological Disorders: Unraveling the Complexities</span> <span class="Link__wrapper"><a aria-label="View all 6 articles" href="https://www.frontiersin.org/research-topics/56723/systems-biology-approaches-to-psychiatric-and-psychological-disorders-unraveling-the-complexities/articles" target="_self" data-event="customLink-link-a_viewAll6Articles" class="Link Link--linkType Link--maincolor Link--medium Link--icon Link--chevronRight Link--right"><span>View all 6 articles</span></a></span></div></div> <div class="ArticleDetails__main__content"><div class="ArticleDetails__main__content__main ArticleDetails__main__content__main--fullArticle"><div class="JournalAbstract"><div class="JournalAbstract__titleWrapper"><h1>Editorial: Systems biology approaches to psychiatric and psychological disorders: unraveling the complexities</h1> </div> </div> <div class="JournalFullText"><div class="JournalAbstract"><a id="h1" name="h1"></a><div class="authors"><span class="author-wrapper notranslate"><a href="https://loop.frontiersin.org/people/1869902" class="user-id-1869902"><img class="pr5" src="https://loop.frontiersin.org/images/profile/1869902/74" onerror="this.onerror=null;this.src='https://loop.frontiersin.org/cdn/images/profile/default_32.jpg';" alt="Ruoting Yang
">Ruoting Yang</a><sup>1</sup>*</span><span class="author-wrapper notranslate"><a href="https://loop.frontiersin.org/people/707628" class="user-id-707628"><img class="pr5" src="https://loop.frontiersin.org/images/profile/707628/74" onerror="this.onerror=null;this.src='https://loop.frontiersin.org/cdn/images/profile/default_32.jpg';" alt="Bernie J. Daigle Jr.">Bernie J. Daigle Jr.</a><sup>2</sup></span><span class="author-wrapper notranslate"><a href="https://loop.frontiersin.org/people/2064352" class="user-id-2064352"><img class="pr5" src="https://loop.frontiersin.org/images/profile/2064352/74" onerror="this.onerror=null;this.src='https://loop.frontiersin.org/cdn/images/profile/default_32.jpg';" alt="Ryan Rampersaud">Ryan Rampersaud</a><sup>3</sup></span><span class="author-wrapper notranslate"><img class="pr5" src="https://loop.frontiersin.org/cdn/images/profile/default_32.jpg" alt="Katharina Schultebraucks" onerror="this.onerror=null;this.src='https://loop.frontiersin.org/cdn/images/profile/default_32.jpg';">Katharina Schultebraucks<sup>4</sup></span></div><ul class="notes"><li><span><sup>1</sup></span>Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD, United States</li><li><span><sup>2</sup></span>Departments of Biological Sciences and Computer Science, University of Memphis, Memphis, TN, United States</li><li><span><sup>3</sup></span>Department of Psychiatry and Behavioral Sciences, University of California San Francisco School of Medicine, San Francisco, CA, United States</li><li><span><sup>4</sup></span>Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States</li></ul><div class="clear"></div></div><div class="JournalFullText"><div class="subheader"><p class="subheadertitle"><b>Editorial on the Research Topic </b><br><a href="https://www.frontiersin.org/research-topics/56723"><b>Systems biology approaches to psychiatric and psychological disorders: unraveling the complexities</b></a></p><div class="clear"></div></div><p>Trauma, whether psychological, physiological, or a combination of both, remains a profound driver of molecular, cellular, and behavioral changes across organisms. The articles in this Research Topic delve into the intricate interplay between genomic, genetic, epigenetic, metabolic, proteomic, and environmental factors contributing to trauma responses and long-term pathophysiological outcomes. This editorial synthesizes key findings from studies exploring novel diagnostic tools, molecular signaling mechanisms, and therapeutic strategies, with a focus on their potential translational applications.</p><p>One central theme in this Research Topic is the role of metabolites as intermediaries of trauma response. <a href="https://doi.org/10.3389/fgene.2024.1394630">Gary et al.</a> highlighted dysregulated pathways in acute stress disorder (ASD), including amino acid metabolism and lipid signaling, revealing potential metabolic biomarkers for early diagnosis and intervention. Similarly, <a href="https://doi.org/10.3389/fgene.2024.1373447">Patel et al.</a> examined how dietary polyunsaturated fatty acids (PUFAs) modulate neuronal resilience to traumatic brain injury (TBI) and stress, implicating diet as a critical factor in mitigating visual and neuronal deficits. Transcriptomic analyses showed that DHA-enriched diets activate pathways such as SNARE signaling, endocannabinoid synapse pathways, and synaptic long-term depression, while suppressing inflammatory cytokine signaling (e.g., IL-6, IL-8) and ferroptosis, underscoring the interaction between PUFA treatment, TBI, and brain signaling networks. These findings emphasize the need to consider both endogenous and environmental influences in understanding stress resilience and vulnerability.</p><p>Another key focus is the gut-brain axis and its role in stress and mood disorders. <a href="https://doi.org/10.3389/fmicb.2024.1337368">Chakraborty et al.</a> reviewed how microbial metabolites mediate the host’s response to environmental stressors, suggesting a bidirectional relationship influencing neuroinflammation and behavior. Furthering our understanding of the gut-brain axis in the context of mental health, <a href="https://doi.org/10.3389/fpsyt.2024.1416009">Pinakhina et al.</a> investigated the intronic variant rs521851 in the MAGI2 (S-SCAM) gene significantly associated with depression symptoms in individuals with a high risk of eating disorders, highlighting its influence on gut-brain axis dysregulation. Their results underscore the genetic underpinnings of psychiatric conditions and reinforce the interplay between genetic predisposition and environmental stressors. Such insights underscore the potential of targeting microbiome-related pathways and considering genetic factors in addressing trauma-related disorders.</p><p>Beyond the gut-brain axis, researchers also employed cutting-edge tools to investigate the complexities of stress response systems. <a href="https://doi.org/10.3389/fgene.2024.1375468">Parker et al.</a> employed neural ordinary differential equations (NODEs) to model the hypothalamic-pituitary-adrenal (HPA) axis dynamics, offering a machine-learning-based framework to predict stress responses in depressive disorders. This innovative approach highlights the growing importance of integrating computational models with biological data to enhance diagnostic accuracy and therapeutic precision.</p><p>In summary, this Research Topic underscores the complexity and interconnectedness of molecular systems in trauma and stress responses. By fostering interdisciplinary collaboration and innovative methodologies, these studies pave the way for more holistic approaches to understanding and mitigating the impacts of trauma on health.</p><a id="h2" name="h2"></a><h2>Author contributions</h2><p class="mb0">RY: Writing–original draft, Writing–review and editing. BD: Writing–original draft, Writing–review and editing. RR: Writing–original draft, Writing–review and editing. KS: Writing–original draft, Writing–review and editing.</p><a id="h3" name="h3"></a><h2>Funding</h2><p class="mb0">The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. BD Jr. was supported by the USAMRAA Department of Defense (Grant Number W81XWH2220078) through a subaward from New York University. KS received support from the National Institute of Mental Health (R01MH129856) and the National Heart, Lung, and Blood Institute (R01HL156134). RY received support from USAMRDC MO230088.</p><a id="h4" name="h4"></a><h2>Conflict of interest</h2><p class="mb0">The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p><a id="h5" name="h5"></a><h2>Generative AI statement</h2><p class="mb15">The author(s) declare that no Generative AI was used in the creation of this manuscript.</p><a id="h6" name="h6"></a><h2>Publisher’s note</h2><p class="mb15">All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p><a id="h7" name="h7"></a><h2>Author disclaimer</h2><p class="mb15">Material has been reviewed by the Walter Reed Army Institute of Research and the US Army Research Institute of Environmental Medicine. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense.</p></div><div class="thinLineM20"></div><div class="AbstractSummary"><p><span>Keywords:</span> systems biology, psychological disorders, computational biology, molecular assay, biomarker</p><p><span>Citation:</span> Yang R, Daigle BJ Jr., Rampersaud R and Schultebraucks K (2025) Editorial: Systems biology approaches to psychiatric and psychological disorders: unraveling the complexities. <em>Front. Genet.</em> 16:1547943. doi: 10.3389/fgene.2025.1547943</p><p id="timestamps"><span>Received:</span> 19 December 2024; <span>Accepted:</span> 06 January 2025;<br><span>Published:</span> 28 January 2025.</p><div><p>Edited and reviewed by:</p> <a href="https://loop.frontiersin.org/people/555998/overview">Roseann E. Peterson</a>, Suny Downstate Health Sciences University, United States</div><p><span>Copyright</span> © 2025 Yang, Daigle, Rampersaud and Schultebraucks. This is an open-access article distributed under the terms of the <a rel="license" href="http://creativecommons.org/licenses/by/4.0/" target="_blank">Creative Commons Attribution License (CC BY).</a> The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p><p><span>*Correspondence:</span> Ruoting Yang, <a id="encmail">cnVvdGluZy55YW5nLmNpdkBoZWFsdGgubWls</a></p><div class="clear"></div></div></div></div> <p class="AbstractSummary__disclaimer"><span>Disclaimer: </span> All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. </p></div></section></main></div> <div></div></div></div>  <footer class="Footer"><div class="Footer__wrapper"><div class="Footer__sections"><ul class="Accordion"><li class="Accordion__item"><button class="Accordion__headline"> <div class="Accordion__title">Guidelines</div> <div class="Accordion__space"></div> <div class="Accordion__arrow"></div></button> <div class="Accordion__content Accordion__content--fadeOut" style="height:0px;"><ul><li><a href="https://www.frontiersin.org/guidelines/author-guidelines" target="_self" data-event="footer-block_0-a_authorGuidelines">Author guidelines</a></li><li><a href="https://www.frontiersin.org/guidelines/editor-guidelines" target="_self" data-event="footer-block_0-a_editorGuidelines">Editor guidelines</a></li><li><a href="https://www.frontiersin.org/guidelines/policies-and-publication-ethics" 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Topics of interest include, but are not limited to:\u003C\u002Fp\u003E\n\n\u003Cdiv\u003E • how genes or genomes relate to traits and human鈥痯athophysiology\u003C\u002Fdiv\u003E\n\u003Cdiv\u003E • advances in genomic data technology and analysis\u003C\u002Fdiv\u003E\n\u003Cdiv\u003E • gene flow among species and populations\u003C\u002Fdiv\u003E\n\u003Cdiv\u003E • livestock genome research Interactions between organisms, their鈥痚nvironment, and xenobiotics\u003C\u002Fdiv\u003E\n\u003Cdiv\u003E • molecular and cellular genetics\u003C\u002Fdiv\u003E\n\u003Cdiv\u003E • societal implications鈥痮f genetic research.\u003C\u002Fdiv\u003E\n\u003Cbr\u003E\n\u003Cp\u003ESubmissions that emphasize advancement in the understanding of the function and variability of the genome, the use of genetic and genomic tools, and the analysis of the genetic underpinnings of biological processes are of particular interest to this journal.\u003Cp\u003E\n\u003Cp\u003EFurthermore, the journal actively welcomes submissions which support and advance the UN鈥檚 Sustainable Development Goals (SDGs), notably SDG 3: good health and well-being.\u003C\u002Fp\u003E\n\u003Cp\u003EManuscripts that focus solely on clinical outcomes, patient management, or therapeutic interventions without a clear genetic or genomic component are not suitable for publication in this journal. Studies that are purely epidemiological or observational, without a foundation in genetic or genomic mechanisms, are also not within the scope of this journal. Manuscripts consisting solely of bioinformatics, computational analyses of public data which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo) or are not highly innovative are not suitable for publication in this journal.\u003C\u002Fp\u003E\n\u003Cp\u003EFrontiers in Genetics is committed to advancing developments in the field of genetics and genomics by allowing unrestricted access to articles, and communicating scientific knowledge to both researchers and the public, to enable the scientific breakthroughs of the future.\u003C\u002Fp\u003E\n",palette:"purple",impactFactor:"3.7",citeScore:"5.2",citations:"186000",showTagline:e,twitter:"@FrontGenetics",__typename:"Journal"},currentFrontiersJournal:{id:p,name:n,slug:q,printISSN:g,shortName:E,electronicISSN:F,abbreviation:V,specialtyId:e,publicationDate:e,isOnline:h,isOpenForSubmissions:h,spaceId:c,field:{id:W,domainId:c,__typename:X},__typename:a},articleHubSlug:g,articleHubPage:G,currentArticle:{id:1547943,doi:Y,title:H,acceptanceDate:new Date(1736150698000),receptionDate:new Date(1734568966000),publicationDate:new Date(1738022400000),isPublished:h,abstract:"\nOne central theme in this Research Topic is the role of metabolites as intermediaries of trauma response. Gary et al. highlighted dysregulated pathways in acute stress disorder (ASD), including amino acid metabolism and lipid signaling, revealing potential metabolic biomarkers for early diagnosis and intervention (Gary, Misganaw et al. 2024). Similarly, Patel et al. examined how dietary polyunsaturated fatty acids (PUFAs) modulate neuronal resilience to traumatic brain injury (TBI) and stress, implicating diet as a critical factor in mitigating visual and neuronal deficits (Patel, Yang et al. 2024). Transcriptomic analyses showed that DHA-enriched diets activate pathways such as SNARE signaling, endocannabinoid synapse pathways, and synaptic long-term depression, while suppressing inflammatory cytokine signaling (e.g., IL-6, IL-8) and ferroptosis, underscoring the interaction between PUFA treatment, TBI, and brain signaling networks. These findings emphasize the need to consider both endogenous and environmental influences in understanding stress resilience and vulnerability.Another key focus is the gut-brain axis and its role in stress and mood disorders. Chakraborty et al. reviewed how microbial metabolites mediate the host's response to environmental stressors, suggesting a bidirectional relationship influencing neuroinflammation and behavior (Chakraborty 2024). Furthering our understanding of the gut-brain axis in the context of mental health, Pinakhina et al. investigated the intronic variant rs521851 in the MAGI2 (S-SCAM) gene significantly associated with depression symptoms in individuals with a high risk of eating disorders, highlighting its influence on gut-brain axis dysregulation (Pinakhina, Kasyanov et al.). Their results underscore the genetic underpinnings of psychiatric conditions and reinforce the interplay between genetic predisposition and environmental stressors. Such insights underscore the potential of targeting microbiome-related pathways and considering genetic factors in addressing trauma-related disorders.Beyond the gut-brain axis, researchers also employed cutting-edge tools to investigate the complexities of stress response systems. Parker et al. employed neural ordinary differential equations (NODEs) to model the hypothalamic-pituitary-adrenal (HPA) axis dynamics, offering a machine-learning-based framework to predict stress responses in depressive disorders (Parker, Nelson et al. 2024). This innovative approach highlights the growing importance of integrating computational models with biological data to enhance diagnostic accuracy and therapeutic precision.In summary, this Research Topic underscores the complexity and interconnectedness of molecular systems in trauma and stress responses. By fostering interdisciplinary collaboration and innovative methodologies, these studies pave the way for more holistic approaches to understanding and mitigating the impacts of trauma on health.\t\t",researchTopic:{id:56723,title:"Systems Biology Approaches to Psychiatric and Psychological Disorders: Unraveling the Complexities",articlesCount:I,isMagazinePage:l,slug:"systems-biology-approaches-to-psychiatric-and-psychological-disorders-unraveling-the-complexities",isOpenForSubmission:l},articleType:{id:83,name:"Editorial"},stage:{id:J,name:g},keywords:["biomarker","computational biology","systems biology","psychological disorders","molecular assay"],authors:[{id:Z,firstName:_,lastName:"Yang",givenNames:_,isCorresponding:l,isProfilePublic:h,userId:Z,affiliations:[{organizationName:"Medical Readiness Systems Biology",countryName:t,cityName:g,stateName:g,zipCode:g}]},{id:$,firstName:aa,lastName:"Daigle",givenNames:aa,isCorresponding:l,isProfilePublic:h,userId:$,affiliations:[{organizationName:"Departments of Biological Sciences and Computer Science",countryName:t,cityName:g,stateName:g,zipCode:g}]},{id:ab,firstName:ac,lastName:"Rampersaud",givenNames:ac,isCorresponding:l,isProfilePublic:h,userId:ab,affiliations:[{organizationName:"Department of Psychiatry and Behavioral Sciences",countryName:t,cityName:g,stateName:g,zipCode:g}]},{id:m,firstName:ad,lastName:"Schultebraucks",givenNames:ad,isCorresponding:l,isProfilePublic:l,userId:m,affiliations:[{organizationName:"Department of Psychiatry",countryName:t,cityName:g,stateName:g,zipCode:g}]}],editors:[{id:ae,firstName:"Roseann",lastName:"Peterson",givenNames:"Roseann E",isCorresponding:l,isProfilePublic:h,userId:ae,affiliations:[{organizationName:g,countryName:g,cityName:g,stateName:g,zipCode:g}]}],reviewers:[],journal:{id:p,slug:q,name:n,shortName:E,electronicISSN:F,field:{id:W,domainId:c,__typename:X},specialtyId:e,journalSectionPaths:[{section:af,__typename:"journal_journalSectionPath"}],__typename:a},section:af,impactMetrics:{views:137,downloads:K,citations:m},volume:aj,articleVolume:"Volume 16 - 2025",relatedArticles:[],isPublishedV2:h,contents:{titleHtml:H,fullTextHtml:"\u003Cdiv class=\"JournalAbstract\"\u003E\u003Ca id=\"h1\" name=\"h1\"\u003E\u003C\u002Fa\u003E\u003Cdiv class=\"authors\"\u003E\u003Cspan class=\"author-wrapper notranslate\"\u003E\u003Ca href=\"https:\u002F\u002Floop.frontiersin.org\u002Fpeople\u002F1869902\" class=\"user-id-1869902\"\u003E\u003Cimg class=\"pr5\" src=\"https:\u002F\u002Floop.frontiersin.org\u002Fimages\u002Fprofile\u002F1869902\u002F74\" onerror=\"this.onerror=null;this.src='https:\u002F\u002Floop.frontiersin.org\u002Fcdn\u002Fimages\u002Fprofile\u002Fdefault_32.jpg';\" alt=\"Ruoting Yang
\"\u003ERuoting Yang\u003C\u002Fa\u003E\u003Csup\u003E1\u003C\u002Fsup\u003E*\u003C\u002Fspan\u003E\u003Cspan class=\"author-wrapper notranslate\"\u003E\u003Ca href=\"https:\u002F\u002Floop.frontiersin.org\u002Fpeople\u002F707628\" class=\"user-id-707628\"\u003E\u003Cimg class=\"pr5\" src=\"https:\u002F\u002Floop.frontiersin.org\u002Fimages\u002Fprofile\u002F707628\u002F74\" onerror=\"this.onerror=null;this.src='https:\u002F\u002Floop.frontiersin.org\u002Fcdn\u002Fimages\u002Fprofile\u002Fdefault_32.jpg';\" alt=\"Bernie J. Daigle Jr.\"\u003EBernie J. Daigle Jr.\u003C\u002Fa\u003E\u003Csup\u003E2\u003C\u002Fsup\u003E\u003C\u002Fspan\u003E\u003Cspan class=\"author-wrapper notranslate\"\u003E\u003Ca href=\"https:\u002F\u002Floop.frontiersin.org\u002Fpeople\u002F2064352\" class=\"user-id-2064352\"\u003E\u003Cimg class=\"pr5\" src=\"https:\u002F\u002Floop.frontiersin.org\u002Fimages\u002Fprofile\u002F2064352\u002F74\" onerror=\"this.onerror=null;this.src='https:\u002F\u002Floop.frontiersin.org\u002Fcdn\u002Fimages\u002Fprofile\u002Fdefault_32.jpg';\" alt=\"Ryan Rampersaud\"\u003ERyan Rampersaud\u003C\u002Fa\u003E\u003Csup\u003E3\u003C\u002Fsup\u003E\u003C\u002Fspan\u003E\u003Cspan class=\"author-wrapper notranslate\"\u003E\u003Cimg class=\"pr5\" src=\"https:\u002F\u002Floop.frontiersin.org\u002Fcdn\u002Fimages\u002Fprofile\u002Fdefault_32.jpg\" alt=\"Katharina Schultebraucks\" onerror=\"this.onerror=null;this.src='https:\u002F\u002Floop.frontiersin.org\u002Fcdn\u002Fimages\u002Fprofile\u002Fdefault_32.jpg';\"\u003EKatharina Schultebraucks\u003Csup\u003E4\u003C\u002Fsup\u003E\u003C\u002Fspan\u003E\u003C\u002Fdiv\u003E\u003Cul class=\"notes\"\u003E\u003Cli\u003E\u003Cspan\u003E\u003Csup\u003E1\u003C\u002Fsup\u003E\u003C\u002Fspan\u003EMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD, United States\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan\u003E\u003Csup\u003E2\u003C\u002Fsup\u003E\u003C\u002Fspan\u003EDepartments of Biological Sciences and Computer Science, University of Memphis, Memphis, TN, United States\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan\u003E\u003Csup\u003E3\u003C\u002Fsup\u003E\u003C\u002Fspan\u003EDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco School of Medicine, San Francisco, CA, United States\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan\u003E\u003Csup\u003E4\u003C\u002Fsup\u003E\u003C\u002Fspan\u003EDepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cdiv class=\"clear\"\u003E\u003C\u002Fdiv\u003E\u003C\u002Fdiv\u003E\u003Cdiv class=\"JournalFullText\"\u003E\u003Cdiv class=\"subheader\"\u003E\u003Cp class=\"subheadertitle\"\u003E\u003Cb\u003EEditorial on the Research Topic \u003C\u002Fb\u003E\u003Cbr\u003E\u003Ca href=\"https:\u002F\u002Fwww.frontiersin.org\u002Fresearch-topics\u002F56723\"\u003E\u003Cb\u003ESystems biology approaches to psychiatric and psychological disorders: unraveling the complexities\u003C\u002Fb\u003E\u003C\u002Fa\u003E\u003C\u002Fp\u003E\u003Cdiv class=\"clear\"\u003E\u003C\u002Fdiv\u003E\u003C\u002Fdiv\u003E\u003Cp\u003ETrauma, whether psychological, physiological, or a combination of both, remains a profound driver of molecular, cellular, and behavioral changes across organisms. The articles in this Research Topic delve into the intricate interplay between genomic, genetic, epigenetic, metabolic, proteomic, and environmental factors contributing to trauma responses and long-term pathophysiological outcomes. This editorial synthesizes key findings from studies exploring novel diagnostic tools, molecular signaling mechanisms, and therapeutic strategies, with a focus on their potential translational applications.\u003C\u002Fp\u003E\u003Cp\u003EOne central theme in this Research Topic is the role of metabolites as intermediaries of trauma response. \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffgene.2024.1394630\"\u003EGary et al.\u003C\u002Fa\u003E highlighted dysregulated pathways in acute stress disorder (ASD), including amino acid metabolism and lipid signaling, revealing potential metabolic biomarkers for early diagnosis and intervention. Similarly, \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffgene.2024.1373447\"\u003EPatel et al.\u003C\u002Fa\u003E examined how dietary polyunsaturated fatty acids (PUFAs) modulate neuronal resilience to traumatic brain injury (TBI) and stress, implicating diet as a critical factor in mitigating visual and neuronal deficits. Transcriptomic analyses showed that DHA-enriched diets activate pathways such as SNARE signaling, endocannabinoid synapse pathways, and synaptic long-term depression, while suppressing inflammatory cytokine signaling (e.g., IL-6, IL-8) and ferroptosis, underscoring the interaction between PUFA treatment, TBI, and brain signaling networks. These findings emphasize the need to consider both endogenous and environmental influences in understanding stress resilience and vulnerability.\u003C\u002Fp\u003E\u003Cp\u003EAnother key focus is the gut-brain axis and its role in stress and mood disorders. \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffmicb.2024.1337368\"\u003EChakraborty et al.\u003C\u002Fa\u003E reviewed how microbial metabolites mediate the host’s response to environmental stressors, suggesting a bidirectional relationship influencing neuroinflammation and behavior. Furthering our understanding of the gut-brain axis in the context of mental health, \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffpsyt.2024.1416009\"\u003EPinakhina et al.\u003C\u002Fa\u003E investigated the intronic variant rs521851 in the MAGI2 (S-SCAM) gene significantly associated with depression symptoms in individuals with a high risk of eating disorders, highlighting its influence on gut-brain axis dysregulation. Their results underscore the genetic underpinnings of psychiatric conditions and reinforce the interplay between genetic predisposition and environmental stressors. Such insights underscore the potential of targeting microbiome-related pathways and considering genetic factors in addressing trauma-related disorders.\u003C\u002Fp\u003E\u003Cp\u003EBeyond the gut-brain axis, researchers also employed cutting-edge tools to investigate the complexities of stress response systems. \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffgene.2024.1375468\"\u003EParker et al.\u003C\u002Fa\u003E employed neural ordinary differential equations (NODEs) to model the hypothalamic-pituitary-adrenal (HPA) axis dynamics, offering a machine-learning-based framework to predict stress responses in depressive disorders. This innovative approach highlights the growing importance of integrating computational models with biological data to enhance diagnostic accuracy and therapeutic precision.\u003C\u002Fp\u003E\u003Cp\u003EIn summary, this Research Topic underscores the complexity and interconnectedness of molecular systems in trauma and stress responses. By fostering interdisciplinary collaboration and innovative methodologies, these studies pave the way for more holistic approaches to understanding and mitigating the impacts of trauma on health.\u003C\u002Fp\u003E\u003Ca id=\"h2\" name=\"h2\"\u003E\u003C\u002Fa\u003E\u003Ch2\u003EAuthor contributions\u003C\u002Fh2\u003E\u003Cp class=\"mb0\"\u003ERY: Writing–original draft, Writing–review and editing. BD: Writing–original draft, Writing–review and editing. RR: Writing–original draft, Writing–review and editing. KS: Writing–original draft, Writing–review and editing.\u003C\u002Fp\u003E\u003Ca id=\"h3\" name=\"h3\"\u003E\u003C\u002Fa\u003E\u003Ch2\u003EFunding\u003C\u002Fh2\u003E\u003Cp class=\"mb0\"\u003EThe author(s) declare that financial support was received for the research, authorship, and\u002For publication of this article. BD Jr. was supported by the USAMRAA Department of Defense (Grant Number W81XWH2220078) through a subaward from New York University. KS received support from the National Institute of Mental Health (R01MH129856) and the National Heart, Lung, and Blood Institute (R01HL156134). RY received support from USAMRDC MO230088.\u003C\u002Fp\u003E\u003Ca id=\"h4\" name=\"h4\"\u003E\u003C\u002Fa\u003E\u003Ch2\u003EConflict of interest\u003C\u002Fh2\u003E\u003Cp class=\"mb0\"\u003EThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.\u003C\u002Fp\u003E\u003Ca id=\"h5\" name=\"h5\"\u003E\u003C\u002Fa\u003E\u003Ch2\u003EGenerative AI statement\u003C\u002Fh2\u003E\u003Cp class=\"mb15\"\u003EThe author(s) declare that no Generative AI was used in the creation of this manuscript.\u003C\u002Fp\u003E\u003Ca id=\"h6\" name=\"h6\"\u003E\u003C\u002Fa\u003E\u003Ch2\u003EPublisher’s note\u003C\u002Fh2\u003E\u003Cp class=\"mb15\"\u003EAll claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.\u003C\u002Fp\u003E\u003Ca id=\"h7\" name=\"h7\"\u003E\u003C\u002Fa\u003E\u003Ch2\u003EAuthor disclaimer\u003C\u002Fh2\u003E\u003Cp class=\"mb15\"\u003EMaterial has been reviewed by the Walter Reed Army Institute of Research and the US Army Research Institute of Environmental Medicine. There is no objection to its presentation and\u002For publication. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense.\u003C\u002Fp\u003E\u003C\u002Fdiv\u003E\u003Cdiv class=\"thinLineM20\"\u003E\u003C\u002Fdiv\u003E\u003Cdiv class=\"AbstractSummary\"\u003E\u003Cp\u003E\u003Cspan\u003EKeywords:\u003C\u002Fspan\u003E systems biology, psychological disorders, computational biology, molecular assay, biomarker\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan\u003ECitation:\u003C\u002Fspan\u003E Yang R, Daigle BJ Jr., Rampersaud R and Schultebraucks K (2025) Editorial: Systems biology approaches to psychiatric and psychological disorders: unraveling the complexities. \u003Cem\u003EFront. Genet.\u003C\u002Fem\u003E 16:1547943. doi: 10.3389\u002Ffgene.2025.1547943\u003C\u002Fp\u003E\u003Cp id=\"timestamps\"\u003E\u003Cspan\u003EReceived:\u003C\u002Fspan\u003E 19 December 2024; \u003Cspan\u003EAccepted:\u003C\u002Fspan\u003E 06 January 2025;\u003Cbr\u003E\u003Cspan\u003EPublished:\u003C\u002Fspan\u003E 28 January 2025.\u003C\u002Fp\u003E\u003Cdiv\u003E\u003Cp\u003EEdited and reviewed by:\u003C\u002Fp\u003E \u003Ca href=\"https:\u002F\u002Floop.frontiersin.org\u002Fpeople\u002F555998\u002Foverview\"\u003ERoseann E. Peterson\u003C\u002Fa\u003E, Suny Downstate Health Sciences University, United States\u003C\u002Fdiv\u003E\u003Cp\u003E\u003Cspan\u003ECopyright\u003C\u002Fspan\u003E © 2025 Yang, Daigle, Rampersaud and Schultebraucks. This is an open-access article distributed under the terms of the \u003Ca rel=\"license\" href=\"http:\u002F\u002Fcreativecommons.org\u002Flicenses\u002Fby\u002F4.0\u002F\" target=\"_blank\"\u003ECreative Commons Attribution License (CC BY).\u003C\u002Fa\u003E The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan\u003E*Correspondence:\u003C\u002Fspan\u003E Ruoting Yang, \u003Ca id=\"encmail\"\u003EcnVvdGluZy55YW5nLmNpdkBoZWFsdGgubWls\u003C\u002Fa\u003E\u003C\u002Fp\u003E\u003Cdiv class=\"clear\"\u003E\u003C\u002Fdiv\u003E\u003C\u002Fdiv\u003E",menuHtml:"\u003Cul class=\"flyoutJournal\"\u003E\u003Cli\u003E\u003Ca href=\"#h2\"\u003EAuthor contributions\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Ca href=\"#h3\"\u003EFunding\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Ca href=\"#h4\"\u003EConflict of interest\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Ca href=\"#h5\"\u003EGenerative AI statement\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Ca href=\"#h6\"\u003EPublisher’s note\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Ca href=\"#h7\"\u003EAuthor disclaimer\u003C\u002Fa\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E"},files:[{name:"EPUB.epub",fileServerPackageEntryId:g,type:{code:"EPUB",name:"epub"}},{name:"fgene-16-1547943.xml",fileServerPackageEntryId:"fgene-16-1547943\u002Ffgene-16-1547943.xml",type:{code:"NLM_XML",name:"xml"}},{name:"Publishers-proof.pdf",fileServerPackageEntryId:g,type:{code:"PDF",name:"pdf"}}]},currentArticlePageMetaInfo:{title:ak,link:[{rel:"canonical",href:al}],meta:[{hid:u,property:u,name:u,content:am},{hid:an,property:an,name:"title",content:ak},{hid:ao,property:ao,name:u,content:am},{hid:ap,name:ap,content:"biomarker,computational biology,systems biology,psychological disorders,molecular assay"},{hid:aq,property:aq,name:"site_name",content:v},{hid:ar,property:ar,name:S,content:T},{hid:as,property:as,name:"type",content:"article"},{hid:at,property:at,name:"url",content:al},{hid:au,name:au,content:"summary_large_image"},{hid:av,name:av,content:"16"},{hid:aw,name:aw,content:n},{hid:ax,name:ax,content:v},{hid:ay,name:ay,content:E},{hid:az,name:az,content:F},{hid:aA,name:aA,content:Y},{hid:aB,name:aB,content:"1547943"},{hid:aC,name:aC,content:"English"},{hid:aD,name:aD,content:H},{hid:aE,name:aE,content:"biomarker; computational biology; systems biology; psychological disorders; molecular assay"},{hid:aF,name:aF,content:"One central theme in this Research Topic is the role of metabolites as intermediaries of trauma response. Gary et al. highlighted dysregulated pathways in acute stress disorder (ASD), including amino acid metabolism and lipid signaling, revealing potential metabolic biomarkers for early diagnosis and intervention (Gary, Misganaw et al. 2024). Similarly, Patel et al. examined how dietary polyunsaturated fatty acids (PUFAs) modulate neuronal resilience to traumatic brain injury (TBI) and stress, implicating diet as a critical factor in mitigating visual and neuronal deficits (Patel, Yang et al. 2024). Transcriptomic analyses showed that DHA-enriched diets activate pathways such as SNARE signaling, endocannabinoid synapse pathways, and synaptic long-term depression, while suppressing inflammatory cytokine signaling (e.g., IL-6, IL-8) and ferroptosis, underscoring the interaction between PUFA treatment, TBI, and brain signaling networks. These findings emphasize the need to consider both endogenous and environmental influences in understanding stress resilience and vulnerability.Another key focus is the gut-brain axis and its role in stress and mood disorders. Chakraborty et al. reviewed how microbial metabolites mediate the host's response to environmental stressors, suggesting a bidirectional relationship influencing neuroinflammation and behavior (Chakraborty 2024). Furthering our understanding of the gut-brain axis in the context of mental health, Pinakhina et al. investigated the intronic variant rs521851 in the MAGI2 (S-SCAM) gene significantly associated with depression symptoms in individuals with a high risk of eating disorders, highlighting its influence on gut-brain axis dysregulation (Pinakhina, Kasyanov et al.). Their results underscore the genetic underpinnings of psychiatric conditions and reinforce the interplay between genetic predisposition and environmental stressors. Such insights underscore the potential of targeting microbiome-related pathways and considering genetic factors in addressing trauma-related disorders.Beyond the gut-brain axis, researchers also employed cutting-edge tools to investigate the complexities of stress response systems. Parker et al. employed neural ordinary differential equations (NODEs) to model the hypothalamic-pituitary-adrenal (HPA) axis dynamics, offering a machine-learning-based framework to predict stress responses in depressive disorders (Parker, Nelson et al. 2024). This innovative approach highlights the growing importance of integrating computational models with biological data to enhance diagnostic accuracy and therapeutic precision.In summary, this Research Topic underscores the complexity and interconnectedness of molecular systems in trauma and stress responses. By fostering interdisciplinary collaboration and innovative methodologies, these studies pave the way for more holistic approaches to understanding and mitigating the impacts of trauma on health.\t\t"},{hid:aG,name:aG,content:"https:\u002F\u002Fwww.frontiersin.org\u002Fjournals\u002Fgenetics\u002Farticles\u002F10.3389\u002Ffgene.2025.1547943\u002Fpdf"},{hid:aH,name:aH,content:"2025\u002F01\u002F06"},{hid:aI,name:aI,content:"2025\u002F01\u002F28"},{hid:"citation_author_0",name:w,content:"Yang, Ruoting"},{hid:"citation_author_institution_0",name:x,content:"Medical Readiness Systems Biology, United States"},{hid:"citation_author_1",name:w,content:"Daigle, Bernie J."},{hid:"citation_author_institution_1",name:x,content:"Departments of Biological Sciences and Computer Science, United States"},{hid:"citation_author_2",name:w,content:"Rampersaud, Ryan"},{hid:"citation_author_institution_2",name:x,content:"Department of Psychiatry and Behavioral Sciences, United 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