CINXE.COM

<!doctype html> <html lang="en"> <head> <title>Rare SARS-CoV-2 Antibody Development in Cancer Patients | 59088</title> <meta name="keywords" content="Louisa Hempel*, Jakob Molnar, Sebastian Robert, Julia Veloso, Zeljka Trepotec, Sofie Englisch, Philip Weinzierl, Cordula Schick, Valeria Milani, Katrin Schweneker, Bastian Fleischmann, Josef Scheiber, Beate Gandorfer, Axel Kleespies, Wolfgang Kaminski, Dirk Hempel, Kristina Riedmann, Armin Piehler, Antibodies; SARS-CoV-2; RT-qPCR; Infection"/> <meta name="description" content="SARS-CoV-2 antibody development and immunity will be crucial for the further course of the pandemic. Until now, it has been assumed that patients who we..59088"/> <meta name="citation_publisher" content="Longdom Publishing SL" /> <meta name="citation_journal_title" content="Immunotherapy: Open Access"> <meta name="citation_title" content="Rare SARS-CoV-2 Antibody Development in Cancer Patients"> <meta name="citation_author" content="Louisa Hempel" /> <meta name="citation_author" content="Jakob Molnar" /> <meta name="citation_author" content="Sebastian Robert" /> <meta name="citation_author" content="Julia Veloso" /> <meta name="citation_author" content="Zeljka Trepotec" /> <meta name="citation_author" content="Sofie Englisch" /> <meta name="citation_author" content="Philip Weinzierl" /> <meta name="citation_author" content="Cordula Schick" /> <meta name="citation_author" content="Valeria Milani" /> <meta name="citation_author" content="Katrin Schweneker" /> <meta name="citation_author" content="Bastian Fleischmann" /> <meta name="citation_author" content="Josef Scheiber" /> <meta name="citation_author" content="Beate G" /> <meta name="citation_author" content="orfer" /> <meta name="citation_author" content="Axel Kleespies" /> <meta name="citation_author" content="Wolfgang Kaminski" /> <meta name="citation_author" content="Dirk Hempel" /> <meta name="citation_author" content="Kristina Riedmann" /> <meta name="citation_author" content="Armin Piehler" /> <meta name="citation_year" content="2020"> <meta name="citation_volume" content="6"> <meta name="citation_issue" content="3"> <meta name="citation_issn" content="2471-9552"> <meta name="citation_publication_date" content="2020/10/28" /> <meta name="citation_firstpage" content="1"> <meta name="citation_lastpage" content="6"> <meta name="citation_abstract" content="SARS-CoV-2 antibody development and immunity will be crucial for the further course of the pandemic. Until now, it has been assumed that patients who were infected with SARS-CoV-2 develop antibodies as it is the case with other coronaviruses, like MERS-CoV and SARS-CoV. In the present study, we analyzed the antibody development of 77 oncology patients 26 days after positive RT-qPCR testing for SARS-CoV2. RT-qPCR and anti-SARS-CoV2-antibody methods from BGI (MGIEasy Magnetic Beads Virus DNA/RNA Extraction Kit) and Roche (Elecsys Anti-SARS- CoV-2 immunoassay) were used, respectively, according to the manufacturers’ specifications. Surprisingly, antibody development was detected in only 6 of 77 individuals with a confirmed history of COVID-19. Despite of multiple testing, the remaining patients did not show measurable antibody concentrations in subsequent tests. These results undermine the previous hypothesis that SARS-CoV2 infections are regularly associated with antibody development and cast doubt on the provided immunity to COVID-19. Understanding the adaptive and humoral response to SARS-CoV2 will play a key-roll in vaccine development and gaining further knowledge on the pathogenesis."> <meta name="citation_pdf_url" content="https://www.longdom.org/open-access/rare-sarscov2-antibody-development-in-cancer-patients.pdf"> <meta name="citation_abstract_html_url" content="https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html"> <meta name="format-detection" content="telephone=no" /> <meta name="google-site-verification" content="NomPTP94YozsgvD3NEFpNqUfY88e0TU0L64zNzZTpd0" /> <meta itemprop="name" content="longdom" /> <meta http-equiv="X-UA-Compatible" content="IE=edge" /> <meta name="ROBOTS" content="INDEX,FOLLOW" /> <meta name="googlebot" content="INDEX,FOLLOW" /> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no" /> <link rel="canonical" href="https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" /> <link rel="alternate" href="https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" hreflang="en-us" /> <script type="application/ld+json"> { "@context": "https://schema.org", "@type": "Organization", "url": "https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html", "logo": "https://www.longdom.org/assets/img/longdom-logo.svg" } </script>  <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/css/bootstrap.min.css" /> <link href="/assets/css/longdom.css" rel="stylesheet" /> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/animate.css/3.7.0/animate.min.css" />  <link rel="stylesheet" href="https://use.fontawesome.com/releases/v5.7.1/css/all.css" /> <link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" />  <link href="https://fonts.googleapis.com/css?family=Montserrat:100,100i,200,200i,300,300i,400,400i,500,500i,600,600i,700,700i,800,800i,900,900i|Open+Sans:300,300i,400,400i,600,600i,700,700i,800,800i|Raleway:100,100i,200,200i,300,300i,400,400i,500,500i,600,600i,700,700i,800,800i,900,900i" rel="stylesheet" /> <link href="/assets/css/ionicons.min.css" rel="stylesheet" />  <link rel="stylesheet" href="/assets/css/jquery.mCustomScrollbar.min.css" /> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/bootstrap-select/1.13.2/css/bootstrap-select.min.css" />  <link rel="stylesheet" href="/assets/css/global.css" />  <link rel="stylesheet" href="/assets/css/styles.css" /> <link rel="stylesheet" type="text/css" href="/assets/css/author.css" /> <link rel="icon" href="/assets/img/favicon.png" type="image/gif" /> <link rel="stylesheet" href="/assets/css/coolautosuggest.css" />   <script async src="https://www.googletagmanager.com/gtag/js?id=G-LE7WH45F9C"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-LE7WH45F9C'); </script> <meta property="og:title" content="Longdom Publishing SL | Open Access Journals" /> <meta property="og:site_name" content="Longdom" /> <meta property="og:url" content="https://www.longdom.org/" /> <meta property="og:description" content="Longdom Publishing SL is one of the leading international open access journals publishers, covering clinical, medical, and technology-oriented subjects" /> <meta property="og:type" content="article" /> <meta property="og:image" content="https://www.longdom.org/assets/img/longdom-logo.svg" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:site" content="@org_longdom" /> <meta name="twitter:title" content="Longdom Publishing SL | Open Access Journals" /> <meta name="twitter:description" content="Longdom Publishing SL is one of the leading international open access journals publishers, covering clinical, medical, and technology-oriented subjects." /> <meta name="twitter:image" content="https://www.longdom.org/assets/img/longdom-logo.svg" />  <script> !function(f,b,e,v,n,t,s){if(f.fbq)return;n=f.fbq=function(){n.callMethod? n.callMethod.apply(n,arguments):n.queue.push(arguments)};if(!f._fbq)f._fbq=n; n.push=n;n.loaded=!0;n.version='2.0';n.queue=[];t=b.createElement(e);t.async=!0; t.src=v;s=b.getElementsByTagName(e)[0];s.parentNode.insertBefore(t,s)}(window, document,'script','//connect.facebook.net/en_US/fbevents.js'); fbq('init', '297919997051754'); fbq('track', "PageView"); </script>  </head> <body> <header>  <nav class="navbar navbar-expand-lg navbar-light bg-white shadow-sm deva541"> <div class="container"> <a class="navbar-brand" href="https://www.longdom.org/" title="Longdom Publishing S.L"> <img src="/assets/img/longdom-logo.svg" alt="" height="25"> </a> <button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse justify-content-end" id="navbar"> <div class="navbar-nav"> <a class="nav-item nav-link" href="https://www.longdom.org/" title="Home">Home</a> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="Guidelines" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Journals</a> <div class="dropdown-menu" aria-labelledby="Journals"> <a class="dropdown-item" href="https://www.longdom.org/journals-by-title.html" title="A-Z Journals">A-Z Journals</a> <a class="dropdown-item" href="https://www.longdom.org/open-access-journals-list.html" title="Browse By Subject">Browse By Subject</a> </div> </div> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="Guidelines" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Guidelines & Policies </a> <div class="dropdown-menu" aria-labelledby="Guidelines"> <a class="dropdown-item" href="https://www.longdom.org/editorial-policies.html" title="Editorial Policies">Editorial Policies</a> <a class="dropdown-item" href="https://www.longdom.org/submit-manuscript.html" title="Online Submission">Online Submission</a> <a class="dropdown-item" href="https://www.longdom.org/instructions-to-authors.html" title="Instructions to Authors">Instructions to Authors</a> <a class="dropdown-item" href="https://www.longdom.org/policies.html" title="Policies">Policies</a> <a class="dropdown-item" href="https://www.longdom.org/publication-ethics.html" title="Publication ethics & malpractice statement">Publication ethics & malpractice statement</a> <a class="dropdown-item" href="https://www.longdom.org/reviewers.html" title="Reviewers">Reviewers</a> <a class="dropdown-item" href="https://www.longdom.org/terms-conditions.html" title="Terms and Conditions">Terms and Conditions</a> </div> </div> <a class="nav-item nav-link" href="https://www.longdom.org/advertising.html" title="Advertising">Advertising</a> <a class="nav-item nav-link" href="https://www.longdom.org/conferences.html" title="Conferences">Conferences</a> <a class="nav-item nav-link" href="https://www.longdom.org/contact-us.html" title="Contact us">Contact us</a> <div id="google_translate_element"></div> </div>  </div> </div> </nav> </header>  <section class="bg-info py-1"> <div class="container"> <div class="row align-items-center justify-content-between">  <div class="col-12 col-sm-3 "> <img src="https://www.longdom.org/admin/headers/immunotherapy-open-access-logo.png" alt="Immunotherapy: Open Access" class="img-fluid mx-auto" width="105" height="105" /> </div> <div class="col-12 col-sm-7"> <h1 class="text-left text-white border-light-blue-200-before font-size-7">Immunotherapy: Open Access<br><small class="float-right font-size-5">Open Access</small></h1> </div>  <div class="col-12 col-sm-2 d-none d-sm-block"> <p class="lead">ISSN: 2471-9552</p>  </div> </div> </div> </section>  <nav id="sticky-navbar" class="navbar navbar-expand-lg navbar-dark bg-primary py-0"> <div class="container"> <button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#jrnlNavbar" aria-controls="jrnlNavbar" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse justify-content-center" id="jrnlNavbar"> <div class="navbar-nav"> <a class="nav-item nav-link " href="https://www.longdom.org/immunotherapy.html" title="Journal Home">Journal Home</a> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle " href="#" id="EditorialPanel" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Editorial Panel <i class="fas fa-caret-down"></i></a> <div class="dropdown-menu" aria-labelledby="EditorialPanel"> <a class="dropdown-item" href="https://www.longdom.org/immunotherapy/editor-in-chief.html" title="Editor-in-Chief">Editor-in-Chief</a> <a class="dropdown-item" href="https://www.longdom.org/immunotherapy/editorial-board.html" title="Editorial Board">Editorial Board</a> </div> </div> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle " title="Instructions for Authors" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false" href="#">Instructions for Authors <i class="fas fa-caret-down"></i></a> <div class="dropdown-menu" aria-labelledby="EditorialPanel"> <a class="dropdown-item" href="https://www.longdom.org/immunotherapy/instructionsforauthors.html" title="Instructions for Authors">Instructions for Authors</a>  <a class="dropdown-item" href="https://www.longdom.org/immunotherapy/ethical-malpractices.html" title="Publication ethics & malpractice statement">Publication ethics & malpractice statement</a> </div> </div> <a class="nav-link " href="https://www.longdom.org/immunotherapy/submit-manuscript.html" title="Submit Manuscript">Submit Manuscript</a> <a class="nav-link " href="https://www.longdom.org/immunotherapy/aims-and-scope.html" title="Aims and Scope">Aims and Scope</a> <a class="nav-link " href="https://www.longdom.org/immunotherapy/inpress.html" title="Articles in process">Articles in process</a>  <a class="nav-link " href="https://www.longdom.org/immunotherapy/upcoming-special-issues.html" title="Special Issue">Special Issue</a> <a class="nav-link " href="https://www.longdom.org/immunotherapy/archive.html" title="Archive">Archive</a> <a class="nav-item nav-link " href="https://www.longdom.org/immunotherapy/contact.html" title="Contact">Contact</a> </div> </div> </div> </nav> <script type="text/javascript"> function googleTranslateElementInit() { new google.translate.TranslateElement({pageLanguage: 'en'}, 'google_translate_element'); } </script> <script type="text/javascript" src="//translate.google.com/translate_a/element.js?cb=googleTranslateElementInit"></script> <section class="py-4 content"> <div class="container"> <div class="row"> <aside class="col-12 col-sm-3 order-last order-sm-first"> <a href="https://www.longdom.org/immunotherapy/awards-nomination.html" class="btn btn-info btn-block mb-3 border-0 border-left-4 border-info font-size-4"><i class="fa-light fa-award-simple"></i> Awards Nomination </a> <a href="https://www.longdom.org/immunotherapy-online-visitors-readers-230.html" class="btn btn-warning btn-block mb-3 border-0 border-left-4 border-info font-size-4"><i class="fas fa-book-reader"></i> 25+ Million Readerbase</a>  <div class="card shadow-sm sidebar mb-3"> <div class="list-group list-group-flush qr_code_image"> <img title="QR" src="https://chart.googleapis.com/chart?chs=185x185&cht=qr&chl=https%3A%2F%2Fwww.longdom.org%2Fabstract%2Frare-sarscov2-antibody-development-in-cancer-patients-59088.html&chld=M|0&icqrf=00b1e4" alt="Longdom"/>  <nav class="nav nav-pills social-icons-footer sidebar_social_icons a-pl-0"> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://www.facebook.com/sharer.php?s=100&p[title]=&p[url]=https%3A%2F%2Fwww.longdom.org%2Fabstract%2Frare-sarscov2-antibody-development-in-cancer-patients-59088.html"><img src="https://www.longdom.org/assets/socials/facebook.png" alt="Longdom" /></a> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://web.whatsapp.com/send?text=https%3A%2F%2Fwww.longdom.org%2Fabstract%2Frare-sarscov2-antibody-development-in-cancer-patients-59088.html" title="Share This Article" target="_blank" class="nav-link"><img src="https://www.longdom.org/assets/socials/whatsapp.png" alt="Longdom"/></a> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fwww.longdom.org%2Fabstract%2Frare-sarscov2-antibody-development-in-cancer-patients-59088.html" title="Share This Article" target="_blank" class="nav-link"><img src="https://www.longdom.org/assets/socials/linkedin.png" alt="Longdom"/></a> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://twitter.com/share?text=&url=https%3A%2F%2Fwww.longdom.org%2Fabstract%2Frare-sarscov2-antibody-development-in-cancer-patients-59088.html" class="nav-link"><img src="https://www.longdom.org/assets/socials/twitter.png" alt="Longdom" /></a> </nav>  </div> </div>   <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header pr-0">PMC/PubMed Indexed Articles</h6> <div class="list-group list-group-flush"> <div class="list-group-item p-0 pt-2 pl-2"> <a class="deep-orange-400-before pr-2" href="https://pubmed.ncbi.nlm.nih.gov/28299372/" title="Anticancer Molecules in Brain: Implication for Novel Strategy for Cancer Immunotherapy" target="_blank">Anticancer Molecules in Brain: Implication for Novel Strategy for Cancer Immunotherapy</a> </div> <div class="list-group-item p-0 pt-2 pl-2"> <a class="deep-orange-400-before pr-2" href="https://pubmed.ncbi.nlm.nih.gov/27081677/" title="Antibody Therapeutics in Oncology" target="_blank">Antibody Therapeutics in Oncology</a> <p class="m-0 clearfix"><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Immunotherapy+%28Los+Angel%29" target="_blank"><span class="btn btn-warning btn-xs float-right">View More »</span></a></p> </div> </div> </div>   <h6><a target="_blank" href="https://scholar.google.com/citations?hl=en&user=3koipBgAAAAJ" title="Click here">Google Scholar citation report</a></h6> <h6 style="font-weight:bold;">Citations : 1028</h6> <p><a target="_blank" href="https://scholar.google.com/citations?hl=en&user=3koipBgAAAAJ" title="Click here">Immunotherapy: Open Access received 1028 citations as per Google Scholar report</a></p> <div class="card shadow-sm sidebar mb-3"> <a href="https://www.longdom.org/immunotherapy/citations.html" title="Click here"><img src="https://www.longdom.org/admin/citation-images/immunotherapy-open-access-citation.PNG" alt="Citation" class="img-fluid p_rel" /></a> </div>   <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header pr-0">Indexed In</h6> <div class="list-group list-group-flush overflow-view"> <div class="list-group-item p-0 pt-2 pl-2"> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> RefSeek </div> <div class="list-group-item p-0 pt-2 pl-2"> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> Hamdard University </div> <div class="list-group-item p-0 pt-2 pl-2"> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> EBSCO A-Z </div> <div class="list-group-item p-0 pt-2 pl-2"> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> OCLC- WorldCat </div> <div class="list-group-item p-0 pt-2 pl-2"> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> Publons </div> <div class="list-group-item p-0 pt-2 pl-2"> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> Geneva Foundation for Medical Education and Research </div> <div class="list-group-item p-0 pt-2 pl-2"> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> Google Scholar </div> </div> <p class="m-0 clearfix"><a href="https://www.longdom.org/immunotherapy/indexing.html" title="Click here"><span class="btn btn-warning btn-xs float-right">View More »</span></a></p> </div>   <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">Useful Links</h6> <div class="card-body p-0"> <nav class="nav flex-column font-size-3 icon-list icon-list-angle-right a-py-1"> <a class="nav-item nav-link" href="https://www.longdom.org/covid-19-peer-reviewed-journals-articles-special-issues.html" title="Click Here">Covid-19 Journal Articles Issues</a> <a class="nav-item nav-link" href="https://www.longdom.org/immunotherapy/aims-and-scope.html" title="Click Here">Aim and Scope</a> <a class="nav-item nav-link" href="https://www.longdom.org/immunotherapy/other-comments.html" title="Click Here">Other Comments</a> <a class="nav-item nav-link" href="https://www.longdom.org/immunotherapy/advertising.html" title="Click Here">Advertising</a> <a class="nav-item nav-link" href="https://www.longdom.org/immunotherapy/citations.html" title="Click Here">Citations Report</a> <a class="nav-item nav-link" href="https://www.longdom.org/immunotherapy/indexing.html" title="Click Here">Indexing and Archiving</a> <a class="nav-item nav-link" href="https://www.longdom.org/immunotherapy/archive.html" title="Click Here">Table of Contents</a> <a class="nav-item nav-link" href="https://www.longdom.org/submissions/immunotherapy-open-access.html" title="Click Here">Submit Paper</a> <a class="nav-item nav-link" href="https://www.longdom.org/editorial-tracking/" title="Click Here">Track Your Paper</a> <a class="nav-item nav-link" href="https://www.longdom.org/funded-articles.html" title="Click Here">Funded Work</a> </nav> </div> </div>  <div class="card shadow-sm sidebar mb-3" style="margin-top:10px"> <h6 class="card-header">Share This Page</h6> <div class="card-body"> <nav class="nav social-icons social-icons-sm"> <a class="nav-link bg-facebook white" href="https://www.facebook.com/sharer.php?u=https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" target="_blank" title="Share with Facebook" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link bg-twitter white" href="https://twitter.com/share?url=https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" rel="noopener" target="_blank" title="Share with Twitter"><i class="fab fa-twitter"></i></a> <a class="nav-link bg-linkedin white" href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" rel="noopener" target="_blank" title="Share with Linkdin"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link bg-googleplus white" href="https://plus.google.com/share?url=https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" target="_blank" rel="noopener" title="Share with Google+"><i class="fab fa-google-plus-g"></i></a> <a class="nav-link bg-pinterest white" href="https://pinterest.com/pin/create/button/?url=https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" rel="noopener" target="_blank" title="Share with Pintrest"><i class="fab fa-pinterest-p"></i></a> <a class="nav-link bg-blogger white" href="https://www.blogger.com/blog-this.g?u=https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" rel="noopener" target="_blank" title="Share with Blogger"><i class="fab fa-blogger-b"></i></a> </nav> </div> </div>  <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">Recommended Journals</h6> <div class="card-body p-0"> <nav class="nav flex-column font-size-3 icon-list icon-list-angle-right a-py-1"> <a class="nav-item nav-link" href="https://www.longdom.org/immunogenetics.html" title="Click Here">immunogenetics Journal</a> <a class="nav-item nav-link" href="https://www.longdom.org/clinical-cellular-immunology.html" title="Click Here">Immunology Journal</a> <a class="nav-item nav-link" href="https://www.longdom.org/immunome-research.html" title="Click Here">Immunome Journal</a> </nav> </div> </div>  <div class="card shadow-sm sidebar mb-3"> <a href="https://www.longdom.org/immunotherapy/advertising.html" title="Click here"><img src="https://www.longdom.org/assets/img/tower-banner.jpg" alt="Flyer image" class="img-fluid p_rel" /> <span class="p_abo cu_roundchip"> <span> <h5><span>25+</span> Million Website Visitors</h5> </span> </span> </a> </div>    <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">Journal Flyer</h6> <img src="https://www.longdom.org/admin/flyers/immunotherapy-open-access-flyer.jpg" alt="Immunotherapy: Open Access" class="img-fluid"/> </div>   <div class="sidebar pt-20 pl-10 mt-xs-0" align="center"> <a class="twitter-timeline" href="https://twitter.com/ImmunotherapyA" data-width="450" data-height="300">Tweets by ImmunotherapyA</a> <script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script> </div> <div class="clear"> </div>   <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">Open Access Journals</h6> <div class="card-body p-0 scroll_mang"> <nav class="nav flex-column font-size-3 icon-list icon-list-angle-right a-py-1"> <a class="nav-item nav-link" href="https://www.longdom.org/agri-and-aquaculture-journals.html" title="Click Here">Agri and Aquaculture</a> <a class="nav-item nav-link" href="https://www.longdom.org/biochemistry-journals.html" title="Click Here">Biochemistry</a> <a class="nav-item nav-link" href="https://www.longdom.org/bioinformatics-and-systems-biology-journals.html" title="Click Here">Bioinformatics & Systems Biology</a> <a class="nav-item nav-link" href="https://www.longdom.org/business-and-management-journals.html" title="Click Here">Business & Management</a> <a class="nav-item nav-link" href="https://www.longdom.org/chemistry-journals.html" title="Click Here">Chemistry</a> <a class="nav-item nav-link" href="https://www.longdom.org/clinical-sciences-journals.html" title="Click Here">Clinical Sciences</a> <a class="nav-item nav-link" href="https://www.longdom.org/engineering-journals.html" title="Click Here">Engineering</a> <a class="nav-item nav-link" href="https://www.longdom.org/food-and-nutrition-journals.html" title="Click Here">Food & Nutrition</a> <a class="nav-item nav-link" href="https://www.longdom.org/general-science-journals.html" title="Click Here">General Science</a> <a class="nav-item nav-link" href="https://www.longdom.org/genetics-and-molecular-biology-journals.html" title="Click Here">Genetics & Molecular Biology</a> <a class="nav-item nav-link" href="https://www.longdom.org/immunology-and-microbiology-journals.html" title="Click Here">Immunology & Microbiology</a> <a class="nav-item nav-link" href="https://www.longdom.org/medical-sciences-journals.html" title="Click Here">Medical Sciences</a> <a class="nav-item nav-link" href="https://www.longdom.org/neuroscience-and-psychology-journals.html" title="Click Here">Neuroscience & Psychology</a> <a class="nav-item nav-link" href="https://www.longdom.org/nursing-and-health-care-journals.html" title="Click Here">Nursing & Health Care</a> <a class="nav-item nav-link" href="https://www.longdom.org/pharmaceutical-sciences-journals.html" title="Click Here">Pharmaceutical Sciences</a> </nav> </div> </div>  </aside> <div class="col-12 col-sm-9"> <h2 class="heading-1">Abstract</h2> <h3 class="">Rare SARS-CoV-2 Antibody Development in Cancer Patients</h3> <p> <i class="fas fa-user"></i> <a href='https://www.longdom.org/author/louisa-hempel-14950' style='color:#555; border-bottom:1px dotted #CCC;' title='Louisa Hempel'>Louisa Hempel</a>*, <a href='https://www.longdom.org/author/jakob-molnar-14951' style='color:#555; border-bottom:1px dotted #CCC;' title='Jakob Molnar'>Jakob Molnar</a>, <a href='https://www.longdom.org/author/sebastian-robert-14952' style='color:#555; border-bottom:1px dotted #CCC;' title='Sebastian Robert'>Sebastian Robert</a>, <a href='https://www.longdom.org/author/julia-veloso-14953' style='color:#555; border-bottom:1px dotted #CCC;' title='Julia Veloso'>Julia Veloso</a>, <a href='https://www.longdom.org/author/zeljka-trepotec-14954' style='color:#555; border-bottom:1px dotted #CCC;' title='Zeljka Trepotec'>Zeljka Trepotec</a>, <a href='https://www.longdom.org/author/sofie-englisch-14955' style='color:#555; border-bottom:1px dotted #CCC;' title='Sofie Englisch'>Sofie Englisch</a>, <a href='https://www.longdom.org/author/philip-weinzierl-14956' style='color:#555; border-bottom:1px dotted #CCC;' title='Philip Weinzierl'>Philip Weinzierl</a>, <a href='https://www.longdom.org/author/cordula-schick-14957' style='color:#555; border-bottom:1px dotted #CCC;' title='Cordula Schick'>Cordula Schick</a>, <a href='https://www.longdom.org/author/valeria-milani-14958' style='color:#555; border-bottom:1px dotted #CCC;' title='Valeria Milani'>Valeria Milani</a>, <a href='https://www.longdom.org/author/katrin-schweneker-14959' style='color:#555; border-bottom:1px dotted #CCC;' title='Katrin Schweneker'>Katrin Schweneker</a>, <a href='https://www.longdom.org/author/bastian-fleischmann-14960' style='color:#555; border-bottom:1px dotted #CCC;' title='Bastian Fleischmann'>Bastian Fleischmann</a>, <a href='https://www.longdom.org/author/josef-scheiber-14961' style='color:#555; border-bottom:1px dotted #CCC;' title='Josef Scheiber'>Josef Scheiber</a>, <a href='https://www.longdom.org/author/beate-gandorfer-14962' style='color:#555; border-bottom:1px dotted #CCC;' title='Beate Gandorfer'>Beate Gandorfer</a>, <a href='https://www.longdom.org/author/axel-kleespies-14963' style='color:#555; border-bottom:1px dotted #CCC;' title='Axel Kleespies'>Axel Kleespies</a>, <a href='https://www.longdom.org/author/wolfgang-kaminski-14964' style='color:#555; border-bottom:1px dotted #CCC;' title='Wolfgang Kaminski'>Wolfgang Kaminski</a>, <a href='https://www.longdom.org/author/dirk-hempel-14965' style='color:#555; border-bottom:1px dotted #CCC;' title='Dirk Hempel'>Dirk Hempel</a>, <a href='https://www.longdom.org/author/kristina-riedmann-14966' style='color:#555; border-bottom:1px dotted #CCC;' title='Kristina Riedmann'>Kristina Riedmann</a> and <a href='https://www.longdom.org/author/armin-piehler-14967' style='color:#555; border-bottom:1px dotted #CCC;' title='Armin Piehler'>Armin Piehler</a> </p> <p> <p>SARS-CoV-2 antibody development and immunity will be crucial for the further course of the pandemic. Until now, it has been assumed that patients who were infected with SARS-CoV-2 develop antibodies as it is the case with other coronaviruses, like MERS-CoV and SARS-CoV. In the present study, we analyzed the antibody development of 77 oncology patients 26 days after positive RT-qPCR testing for SARS-CoV2. RT-qPCR and anti-SARS-CoV2-antibody methods from BGI (MGIEasy Magnetic Beads Virus DNA/RNA Extraction Kit) and Roche (Elecsys Anti-SARS- CoV-2 immunoassay) were used, respectively, according to the manufacturers’ specifications.</p> <p>Surprisingly, antibody development was detected in only 6 of 77 individuals with a confirmed history of COVID-19. Despite of multiple testing, the remaining patients did not show measurable antibody concentrations in subsequent tests. These results undermine the previous hypothesis that SARS-CoV2 infections are regularly associated with antibody development and cast doubt on the provided immunity to COVID-19. Understanding the adaptive and humoral response to SARS-CoV2 will play a key-roll in vaccine development and gaining further knowledge on the pathogenesis.</p> </p> <p class="mb-1 font-size-3 text-muted"> <b>Published Date: </b> 2020-10-28; <b>Received Date: </b>2020-09-29</p> <nav class="nav a-pl-0"> <a href="https://www.longdom.org/open-access/rare-sarscov2-antibody-development-in-cancer-patients.pdf" title="Click here" class="nav-link text-success"><img src="/assets/img/PDF_32.png" alt="pdf" height="26"></a> </nav> <div class="nav social-icons"> <a class="nav-link w-auto">Share this article</a> <a title="Click here" target="_blank" href="https://www.facebook.com/sharer.php?u=https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="Click here" target="_blank" href="https://twitter.com/share?url=https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="Click here" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="Click here" target="_blank" href="https://plus.google.com/share?url=https://www.longdom.org/abstract/rare-sarscov2-antibody-development-in-cancer-patients-59088.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Content Links</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://www.longdom.org/online-tools.html" title="Click here">Tools</a> </li> <li><a class="" href="https://www.longdom.org/feedback.html" title="Click here">Feedback</a></li> <li><a class="" href="https://www.longdom.org/careers.html" title="Click here">Careers</a></li> <li><a class="" href="https://www.longdom.org/privacy-policy.html" title="Click here">Privacy Policy</a></li> <li><a class="" href="https://www.longdom.org/terms-conditions.html" title="Click here">Terms & Conditions</a></li> <li><a class="" href="https://www.longdom.org/authors-reviewers-editors.html" title="Click here">Authors, Reviewers & Editors</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Contact Longdom</h4> <p>Longdom Group SA<br> Avenue Roger Vandendriessche,<br> 18, 1150 Brussels, Belgium<br> Phone: +442038085340 <br><strong>Email:</strong> <a href="mailto:info@longdom.org" class="white" title="Click here">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Connect</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="Click here" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i> Facebook</a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="Click here" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i> Linkedin</a> <a href="https://twitter.com/LongdomP" title="Click here" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i> Twitter</a> <a href="https://www.instagram.com/longdom_publisher/" title="Click here" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i> Instagram</a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>Copyright © 2024 <a href="https://www.longdom.org/" title="Click here" class="white">Longdom Publishing</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script defer src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script defer src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script defer src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? { 'position': 'fixed', 'top': '440px' } : { 'position': 'absolute', 'top': '440px' } ); return fix_element; }()); }); </script>   <script defer src="https://unpkg.com/feather-icons"></script> <script> feather.replace() </script>  <script defer src="/assets/js/scroll-to-top.js"></script>  <script defer type="text/javascript" src="/assets/js/coolautosuggest.js"></script> <script language="javascript" type="text/javascript"> $("#keyword").coolautosuggest({ url: "https://www.longdom.org/author-names.php?chars=", minChars: 3, }); </script> <script defer src="/assets/js/jquery.mCustomScrollbar.concat.min.js"></script> <script> // Scrollbar var Scrollbar = function() { "use strict"; // Handle Scrollbar Linear var handleScrollbarLinear = function() { $(".scrollbar").mCustomScrollbar({ theme: "minimal-dark" }); } return { init: function() { handleScrollbarLinear(); // initial setup for scrollbar linear } } }(); $(document).ready(function() { Scrollbar.init(); }); /*========================== Stikcy Navbar ============================*/ window.onscroll = function() { myFunction() }; var navbar = document.getElementById("sticky-navbar"); var sticky = navbar.offsetTop; function myFunction() { if (window.pageYOffset >= sticky) { navbar.classList.add("sticky") } else { navbar.classList.remove("sticky"); } } /*========================== Bootstrap Popover ============================*/ $(function () { $('[data-toggle="popover"]').popover() }) </script>  <script defer src="/assets/js/jquery.malihu.PageScroll2id.min.js"></script> <script> (function($){ $(window).on("load",function(){ $("a[rel='m_PageScroll2id']").mPageScroll2id(); }); })(jQuery); </script>  <script defer type="text/javascript" src="/assets/js/jquery.matchHeight-min.js"></script> <script> $(function() { $('.match-height').matchHeight({ byRow: true, property: 'height', target: null, }); }); </script> <script defer type="text/javascript" src="/assets/js/grids.min.js"></script> <script type="text/javascript"> // Equal Height var EqualHeight = function() { "use strict"; // Handle Equal Height var handleEqualHeight = function() { $(function($) { $('.equal-height').responsiveEqualHeightGrid(); }); } return { init: function() { handleEqualHeight(); // initial setup for equal height } } }(); $(document).ready(function() { EqualHeight.init(); }); </script>  <script defer src="https://cdnjs.cloudflare.com/ajax/libs/bootstrap-select/1.13.2/js/bootstrap-select.min.js"></script> <script> $('.selectpicker').selectpicker(); </script> <script> $(document).ready(function(){ var filecount = 1; $('.filerowclass').each(function(){ var countattr = $(this).attr('countattr'); if(filecount == countattr){ var countlink = $('#rowfile'+countattr+ ' .filelinkclass').length; if(countlink == 0){ $('#rowfile'+countattr).remove(); } } filecount++; }); }); </script>  <script type="text/javascript"> $(document).ready(function() { $("#wait").hide(); $("#jkeyword").keyup(function() { $("#wait").show(); //values of sending variables var jkeyword=$("#jkeyword").val(); var dataString = { 'jkeyword':jkeyword }; $.ajax ({ type: "POST", url: "https://www.longdom.org/journal-search.php", data: dataString, cache: false, success: function(html) { $("#jresult").html(html); $("#wait").hide(); } }); }); }); </script> <link href="https://cdn.jsdelivr.net/npm/select2@4.1.0-rc.0/dist/css/select2.min.css" rel="stylesheet" /> <script defer src="https://cdn.jsdelivr.net/npm/select2@4.1.0-rc.0/dist/js/select2.min.js"></script> </body> </html>