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vector-toc-toggle"> Toggle Cause subsection </button> <ul id="toc-Cause-sublist" class="vector-toc-list"> <li id="toc-Tick_life_cycle" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Tick_life_cycle"> <div class="vector-toc-text"> 2.1 Tick life cycle </div> </a> <ul id="toc-Tick_life_cycle-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Transmission" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Transmission"> <div class="vector-toc-text"> 2.2 Transmission </div> </a> <ul id="toc-Transmission-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Tick-borne_co-infections" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Tick-borne_co-infections"> <div class="vector-toc-text"> 2.3 Tick-borne co-infections </div> </a> <ul id="toc-Tick-borne_co-infections-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Pathophysiology" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Pathophysiology"> <div class="vector-toc-text"> 3 Pathophysiology </div> </a> <button aria-controls="toc-Pathophysiology-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Pathophysiology subsection </button> <ul id="toc-Pathophysiology-sublist" class="vector-toc-list"> <li id="toc-Immunological_studies" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Immunological_studies"> <div class="vector-toc-text"> 3.1 Immunological studies </div> </a> <ul id="toc-Immunological_studies-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Diagnosis" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Diagnosis"> <div class="vector-toc-text"> 4 Diagnosis </div> </a> <button aria-controls="toc-Diagnosis-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Diagnosis subsection </button> <ul id="toc-Diagnosis-sublist" class="vector-toc-list"> <li id="toc-Laboratory_testing" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Laboratory_testing"> <div class="vector-toc-text"> 4.1 Laboratory testing </div> </a> <ul id="toc-Laboratory_testing-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Imaging" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Imaging"> <div class="vector-toc-text"> 4.2 Imaging </div> </a> <ul id="toc-Imaging-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Differential_diagnosis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Differential_diagnosis"> <div class="vector-toc-text"> 4.3 Differential diagnosis </div> </a> <ul id="toc-Differential_diagnosis-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Prevention" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Prevention"> <div class="vector-toc-text"> 5 Prevention </div> </a> <button aria-controls="toc-Prevention-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Prevention subsection </button> <ul id="toc-Prevention-sublist" class="vector-toc-list"> <li id="toc-Tick_removal" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Tick_removal"> <div class="vector-toc-text"> 5.1 Tick removal </div> </a> <ul id="toc-Tick_removal-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Preventive_antibiotics" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Preventive_antibiotics"> <div class="vector-toc-text"> 5.2 Preventive antibiotics </div> </a> <ul id="toc-Preventive_antibiotics-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Garden_landscaping" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Garden_landscaping"> <div class="vector-toc-text"> 5.3 Garden landscaping </div> </a> <ul id="toc-Garden_landscaping-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Occupational_exposure" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Occupational_exposure"> <div class="vector-toc-text"> 5.4 Occupational exposure </div> </a> <ul id="toc-Occupational_exposure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Host_animals" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Host_animals"> <div class="vector-toc-text"> 5.5 Host animals </div> </a> <ul id="toc-Host_animals-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Vaccination" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Vaccination"> <div class="vector-toc-text"> 6 Vaccination </div> </a> <button aria-controls="toc-Vaccination-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Vaccination subsection </button> <ul id="toc-Vaccination-sublist" class="vector-toc-list"> <li id="toc-LYMErix" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#LYMErix"> <div class="vector-toc-text"> 6.1 LYMErix </div> </a> <ul id="toc-LYMErix-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-VLA15" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#VLA15"> <div class="vector-toc-text"> 6.2 VLA15 </div> </a> <ul id="toc-VLA15-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Other_research" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Other_research"> <div class="vector-toc-text"> 6.3 Other research </div> </a> <ul id="toc-Other_research-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Canine_vaccines" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Canine_vaccines"> <div class="vector-toc-text"> 6.4 Canine vaccines </div> </a> <ul id="toc-Canine_vaccines-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Treatment" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Treatment"> <div class="vector-toc-text"> 7 Treatment </div> </a> <ul id="toc-Treatment-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Prognosis" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Prognosis"> <div class="vector-toc-text"> 8 Prognosis </div> </a> <button aria-controls="toc-Prognosis-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Prognosis subsection </button> <ul id="toc-Prognosis-sublist" class="vector-toc-list"> <li id="toc-Post-treatment_Lyme_disease_syndrome" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Post-treatment_Lyme_disease_syndrome"> <div class="vector-toc-text"> 8.1 Post-treatment Lyme disease syndrome </div> </a> <ul id="toc-Post-treatment_Lyme_disease_syndrome-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Epidemiology" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Epidemiology"> <div class="vector-toc-text"> 9 Epidemiology </div> </a> <button aria-controls="toc-Epidemiology-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Epidemiology subsection </button> <ul id="toc-Epidemiology-sublist" class="vector-toc-list"> <li id="toc-Africa" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Africa"> <div class="vector-toc-text"> 9.1 Africa </div> </a> <ul id="toc-Africa-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Asia" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Asia"> <div class="vector-toc-text"> 9.2 Asia </div> </a> <ul id="toc-Asia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Australia" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Australia"> <div class="vector-toc-text"> 9.3 Australia </div> </a> <ul id="toc-Australia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Europe" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Europe"> <div class="vector-toc-text"> 9.4 Europe </div> </a> <ul id="toc-Europe-sublist" class="vector-toc-list"> <li id="toc-United_Kingdom" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#United_Kingdom"> <div class="vector-toc-text"> 9.4.1 United Kingdom </div> </a> <ul id="toc-United_Kingdom-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-North_America" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#North_America"> <div class="vector-toc-text"> 9.5 North America </div> </a> <ul id="toc-North_America-sublist" class="vector-toc-list"> <li id="toc-Canada" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Canada"> <div class="vector-toc-text"> 9.5.1 Canada </div> </a> <ul id="toc-Canada-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mexico" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Mexico"> <div class="vector-toc-text"> 9.5.2 Mexico </div> </a> <ul id="toc-Mexico-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-United_States" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#United_States"> <div class="vector-toc-text"> 9.5.3 United States </div> </a> <ul id="toc-United_States-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-South_America" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#South_America"> <div class="vector-toc-text"> 9.6 South America </div> </a> <ul id="toc-South_America-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Etymology" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Etymology"> <div class="vector-toc-text"> 10 Etymology </div> </a> <ul id="toc-Etymology-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-History" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#History"> <div class="vector-toc-text"> 11 History </div> </a> <ul id="toc-History-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Society,_culture,_and_controversy" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Society,_culture,_and_controversy"> <div class="vector-toc-text"> 12 Society, culture, and controversy </div> </a> <button aria-controls="toc-Society,_culture,_and_controversy-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Society, culture, and controversy subsection </button> <ul id="toc-Society,_culture,_and_controversy-sublist" class="vector-toc-list"> <li id="toc-Landscape_changes_and_urbanization" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Landscape_changes_and_urbanization"> <div class="vector-toc-text"> 12.1 Landscape changes and urbanization </div> </a> <ul id="toc-Landscape_changes_and_urbanization-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-The_dilution_effect" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#The_dilution_effect"> <div class="vector-toc-text"> 12.2 The dilution effect </div> </a> <ul id="toc-The_dilution_effect-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Chronic_Lyme_disease" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Chronic_Lyme_disease"> <div class="vector-toc-text"> 12.3 Chronic Lyme disease </div> </a> <ul id="toc-Chronic_Lyme_disease-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Other_animals" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Other_animals"> <div class="vector-toc-text"> 13 Other animals </div> </a> <button aria-controls="toc-Other_animals-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Other animals subsection </button> <ul id="toc-Other_animals-sublist" class="vector-toc-list"> <li id="toc-Dogs" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Dogs"> <div class="vector-toc-text"> 13.1 Dogs </div> </a> <ul id="toc-Dogs-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Cats" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cats"> <div class="vector-toc-text"> 13.2 Cats </div> </a> <ul id="toc-Cats-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Horses" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Horses"> <div class="vector-toc-text"> 13.3 Horses </div> </a> <ul id="toc-Horses-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> 14 References </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> 15 Further reading </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> 16 External links </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" > Toggle the table of contents </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading">Lyme disease</h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 66 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-66" aria-hidden="true" > 66 languages </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AF%D8%A7%D8%A1_%D9%84%D8%A7%D9%8A%D9%85" title="داء لايم – Arabic" lang="ar" hreflang="ar" data-title="داء لايم" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target">العربية</a></li><li class="interlanguage-link interwiki-ast mw-list-item"><a href="https://ast.wikipedia.org/wiki/Enfermed%C3%A1_de_Lyme" title="Enfermedá de Lyme – Asturian" lang="ast" hreflang="ast" data-title="Enfermedá de Lyme" data-language-autonym="Asturianu" data-language-local-name="Asturian" class="interlanguage-link-target">Asturianu</a></li><li class="interlanguage-link interwiki-az mw-list-item"><a href="https://az.wikipedia.org/wiki/Laym_x%C9%99st%C9%99liyi" title="Laym xəstəliyi – Azerbaijani" lang="az" hreflang="az" data-title="Laym xəstəliyi" data-language-autonym="Azərbaycanca" data-language-local-name="Azerbaijani" class="interlanguage-link-target">Azərbaycanca</a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D9%84%D8%A7%DB%8C%D9%85_%D9%85%D8%B1%DB%8C%D8%B6%D9%84%DB%8C%DA%AF%DB%8C" title="لایم مریضلیگی – South Azerbaijani" lang="azb" hreflang="azb" data-title="لایم مریضلیگی" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target">تۆرکجه</a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%B2%E0%A6%BE%E0%A6%87%E0%A6%AE_%E0%A6%B0%E0%A7%8B%E0%A6%97" title="লাইম রোগ – Bangla" lang="bn" hreflang="bn" data-title="লাইম রোগ" data-language-autonym="বাংলা" data-language-local-name="Bangla" class="interlanguage-link-target">বাংলা</a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%9B%D0%B0%D0%B9%D0%BC-%D0%B1%D0%B0%D1%80%D1%8D%D0%BB%D1%96%D1%91%D0%B7" title="Лайм-барэліёз – Belarusian" lang="be" hreflang="be" data-title="Лайм-барэліёз" data-language-autonym="Беларуская" data-language-local-name="Belarusian" class="interlanguage-link-target">Беларуская</a></li><li class="interlanguage-link interwiki-be-x-old mw-list-item"><a href="https://be-tarask.wikipedia.org/wiki/%D0%91%D0%B0%D1%80%D1%8D%D0%BB%D1%96%D1%91%D0%B7" title="Барэліёз – Belarusian (Taraškievica orthography)" lang="be-tarask" hreflang="be-tarask" data-title="Барэліёз" data-language-autonym="Беларуская (тарашкевіца)" data-language-local-name="Belarusian (Taraškievica orthography)" class="interlanguage-link-target">Беларуская (тарашкевіца)</a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%9B%D0%B0%D0%B9%D0%BC%D1%81%D0%BA%D0%B0_%D0%B1%D0%BE%D0%BB%D0%B5%D1%81%D1%82" title="Лаймска болест – Bulgarian" lang="bg" hreflang="bg" data-title="Лаймска болест" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target">Български</a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Lajmska_bolest" title="Lajmska bolest – Bosnian" lang="bs" hreflang="bs" data-title="Lajmska bolest" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target">Bosanski</a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Malaltia_de_Lyme" title="Malaltia de Lyme – Catalan" lang="ca" hreflang="ca" data-title="Malaltia de Lyme" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target">Català</a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Lymesk%C3%A1_nemoc" title="Lymeská nemoc – Czech" lang="cs" hreflang="cs" data-title="Lymeská nemoc" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target">Čeština</a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Clefyd_Lyme" title="Clefyd Lyme – Welsh" lang="cy" hreflang="cy" data-title="Clefyd Lyme" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target">Cymraeg</a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Borreliose" title="Borreliose – Danish" lang="da" hreflang="da" data-title="Borreliose" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target">Dansk</a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Lyme-Borreliose" title="Lyme-Borreliose – German" lang="de" hreflang="de" data-title="Lyme-Borreliose" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target">Deutsch</a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Lyme%27i_t%C3%B5bi" title="Lyme'i tõbi – Estonian" lang="et" hreflang="et" data-title="Lyme'i tõbi" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target">Eesti</a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%92%CE%BF%CF%81%CF%81%CE%B5%CE%BB%CE%AF%CF%89%CF%83%CE%B7" title="Βορρελίωση – Greek" lang="el" hreflang="el" data-title="Βορρελίωση" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target">Ελληνικά</a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Enfermedad_de_Lyme" title="Enfermedad de Lyme – Spanish" lang="es" hreflang="es" data-title="Enfermedad de Lyme" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target">Español</a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Boreliozo_Lyme" title="Boreliozo Lyme – Esperanto" lang="eo" hreflang="eo" data-title="Boreliozo Lyme" data-language-autonym="Esperanto" data-language-local-name="Esperanto" class="interlanguage-link-target">Esperanto</a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Lyme_gaitz" title="Lyme gaitz – Basque" lang="eu" hreflang="eu" data-title="Lyme gaitz" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target">Euskara</a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A8%DB%8C%D9%85%D8%A7%D8%B1%DB%8C_%D9%84%D8%A7%DB%8C%D9%85" title="بیماری لایم – Persian" lang="fa" hreflang="fa" data-title="بیماری لایم" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target">فارسی</a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Maladie_de_Lyme" title="Maladie de Lyme – French" lang="fr" hreflang="fr" data-title="Maladie de Lyme" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target">Français</a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/Galar_Lyme" title="Galar Lyme – Irish" lang="ga" hreflang="ga" data-title="Galar Lyme" data-language-autonym="Gaeilge" data-language-local-name="Irish" class="interlanguage-link-target">Gaeilge</a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Doenza_de_Lyme" title="Doenza de Lyme – Galician" lang="gl" hreflang="gl" data-title="Doenza de Lyme" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target">Galego</a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%9D%BC%EC%9E%84%EB%B3%91" title="라임병 – Korean" lang="ko" hreflang="ko" data-title="라임병" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target">한국어</a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%BC%D5%A1%D5%B5%D5%B4%D5%AB_%D5%B0%D5%AB%D5%BE%D5%A1%D5%B6%D5%A4%D5%B8%D6%82%D5%A9%D5%B5%D5%B8%D6%82%D5%B6" title="Լայմի հիվանդություն – Armenian" lang="hy" hreflang="hy" data-title="Լայմի հիվանդություն" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target">Հայերեն</a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Lajmska_borelioza" title="Lajmska borelioza – Croatian" lang="hr" hreflang="hr" data-title="Lajmska borelioza" data-language-autonym="Hrvatski" data-language-local-name="Croatian" class="interlanguage-link-target">Hrvatski</a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Penyakit_Lyme" title="Penyakit Lyme – Indonesian" lang="id" hreflang="id" data-title="Penyakit Lyme" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target">Bahasa Indonesia</a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Malattia_di_Lyme" title="Malattia di Lyme – Italian" lang="it" hreflang="it" data-title="Malattia di Lyme" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target">Italiano</a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%9E%D7%97%D7%9C%D7%AA_%D7%9C%D7%99%D7%99%D7%9D" title="מחלת ליים – Hebrew" lang="he" hreflang="he" data-title="מחלת ליים" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target">עברית</a></li><li class="interlanguage-link interwiki-jv mw-list-item"><a href="https://jv.wikipedia.org/wiki/Penyakit_Lyme" title="Penyakit Lyme – Javanese" lang="jv" hreflang="jv" data-title="Penyakit Lyme" data-language-autonym="Jawa" data-language-local-name="Javanese" class="interlanguage-link-target">Jawa</a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%9B%D0%B0%D0%B9%D0%BC_%D0%B0%D1%83%D1%80%D1%83%D1%8B_(%D0%9A%D0%B5%D0%BD%D0%B5_%D0%B1%D0%BE%D1%80%D1%80%D0%B5%D0%BB%D0%B8%D0%BE%D0%B7%D1%8B)" title="Лайм ауруы (Кене боррелиозы) – Kazakh" lang="kk" hreflang="kk" data-title="Лайм ауруы (Кене боррелиозы)" data-language-autonym="Қазақша" data-language-local-name="Kazakh" class="interlanguage-link-target">Қазақша</a></li><li class="interlanguage-link interwiki-lo mw-list-item"><a href="https://lo.wikipedia.org/wiki/%E0%BA%9E%E0%BA%B0%E0%BA%8D%E0%BA%B2%E0%BA%94%E0%BB%84%E0%BA%A5%E0%BA%A1" title="ພະຍາດໄລມ – Lao" lang="lo" hreflang="lo" data-title="ພະຍາດໄລມ" data-language-autonym="ລາວ" data-language-local-name="Lao" class="interlanguage-link-target">ລາວ</a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Laimas_slim%C4%ABba" title="Laimas slimība – Latvian" lang="lv" hreflang="lv" data-title="Laimas slimība" data-language-autonym="Latviešu" data-language-local-name="Latvian" class="interlanguage-link-target">Latviešu</a></li><li class="interlanguage-link interwiki-lb mw-list-item"><a href="https://lb.wikipedia.org/wiki/Lyme-Borrelios" title="Lyme-Borrelios – Luxembourgish" lang="lb" hreflang="lb" data-title="Lyme-Borrelios" data-language-autonym="Lëtzebuergesch" data-language-local-name="Luxembourgish" class="interlanguage-link-target">Lëtzebuergesch</a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Laimo_liga" title="Laimo liga – Lithuanian" lang="lt" hreflang="lt" data-title="Laimo liga" data-language-autonym="Lietuvių" data-language-local-name="Lithuanian" class="interlanguage-link-target">Lietuvių</a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Lyme-k%C3%B3r" title="Lyme-kór – Hungarian" lang="hu" hreflang="hu" data-title="Lyme-kór" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target">Magyar</a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%9B%D0%B0%D1%98%D0%BC%D1%81%D0%BA%D0%B0_%D0%B1%D0%BE%D0%BB%D0%B5%D1%81%D1%82" title="Лајмска болест – Macedonian" lang="mk" hreflang="mk" data-title="Лајмска болест" data-language-autonym="Македонски" data-language-local-name="Macedonian" class="interlanguage-link-target">Македонски</a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%B2%E0%B5%88%E0%B4%82_%E0%B4%B0%E0%B5%8B%E0%B4%97%E0%B4%82" title="ലൈം രോഗം – Malayalam" lang="ml" hreflang="ml" data-title="ലൈം രോഗം" data-language-autonym="മലയാളം" data-language-local-name="Malayalam" class="interlanguage-link-target">മലയാളം</a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Penyakit_Lyme" title="Penyakit Lyme – Malay" lang="ms" hreflang="ms" data-title="Penyakit Lyme" data-language-autonym="Bahasa Melayu" data-language-local-name="Malay" class="interlanguage-link-target">Bahasa Melayu</a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Lymeziekte" title="Lymeziekte – Dutch" lang="nl" hreflang="nl" data-title="Lymeziekte" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target">Nederlands</a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%A9%E3%82%A4%E3%83%A0%E7%97%85" title="ライム病 – Japanese" lang="ja" hreflang="ja" data-title="ライム病" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target">日本語</a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%B2%E0%AC%BE%E0%AC%87%E0%AC%AE_%E0%AC%B0%E0%AD%8B%E0%AC%97" title="ଲାଇମ ରୋଗ – Odia" lang="or" hreflang="or" data-title="ଲାଇମ ରୋଗ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target">ଓଡ଼ିଆ</a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Lyme_kasalligi" title="Lyme kasalligi – Uzbek" lang="uz" hreflang="uz" data-title="Lyme kasalligi" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="Uzbek" class="interlanguage-link-target">Oʻzbekcha / ўзбекча</a></li><li class="interlanguage-link interwiki-ps mw-list-item"><a href="https://ps.wikipedia.org/wiki/%D9%84%D8%A7%D9%8A%D9%85_%D9%86%D8%A7%D8%B1%D9%88%D8%BA%D9%8A" title="لايم ناروغي – Pashto" lang="ps" hreflang="ps" data-title="لايم ناروغي" data-language-autonym="پښتو" data-language-local-name="Pashto" class="interlanguage-link-target">پښتو</a></li><li class="interlanguage-link interwiki-pl badge-Q17437798 badge-goodarticle mw-list-item" title="good article badge"><a href="https://pl.wikipedia.org/wiki/Borelioza" title="Borelioza – Polish" lang="pl" hreflang="pl" data-title="Borelioza" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target">Polski</a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Doen%C3%A7a_de_Lyme" title="Doença de Lyme – Portuguese" lang="pt" hreflang="pt" data-title="Doença de Lyme" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target">Português</a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Boala_Lyme" title="Boala Lyme – Romanian" lang="ro" hreflang="ro" data-title="Boala Lyme" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target">Română</a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%91%D0%BE%D0%BB%D0%B5%D0%B7%D0%BD%D1%8C_%D0%9B%D0%B0%D0%B9%D0%BC%D0%B0" title="Болезнь Лайма – Russian" lang="ru" hreflang="ru" data-title="Болезнь Лайма" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target">Русский</a></li><li class="interlanguage-link interwiki-sco mw-list-item"><a href="https://sco.wikipedia.org/wiki/Lyme_disease" title="Lyme disease – Scots" lang="sco" hreflang="sco" data-title="Lyme disease" data-language-autonym="Scots" data-language-local-name="Scots" class="interlanguage-link-target">Scots</a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Lyme_disease" title="Lyme disease – Simple English" lang="en-simple" hreflang="en-simple" data-title="Lyme disease" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target">Simple English</a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Lymsk%C3%A1_boreli%C3%B3za" title="Lymská borelióza – Slovak" lang="sk" hreflang="sk" data-title="Lymská borelióza" data-language-autonym="Slovenčina" data-language-local-name="Slovak" class="interlanguage-link-target">Slovenčina</a></li><li class="interlanguage-link interwiki-sl badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://sl.wikipedia.org/wiki/Lymska_borelioza" title="Lymska borelioza – Slovenian" lang="sl" hreflang="sl" data-title="Lymska borelioza" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target">Slovenščina</a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%9B%D0%B0%D1%98%D0%BC%D1%81%D0%BA%D0%B0_%D0%B1%D0%BE%D0%BB%D0%B5%D1%81%D1%82" title="Лајмска болест – Serbian" lang="sr" hreflang="sr" data-title="Лајмска болест" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target">Српски / srpski</a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Lajmska_bolest" title="Lajmska bolest – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Lajmska bolest" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target">Srpskohrvatski / српскохрватски</a></li><li class="interlanguage-link interwiki-fi badge-Q17437798 badge-goodarticle mw-list-item" title="good article badge"><a href="https://fi.wikipedia.org/wiki/Borrelioosi" title="Borrelioosi – Finnish" lang="fi" hreflang="fi" data-title="Borrelioosi" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target">Suomi</a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Borreliainfektion" title="Borreliainfektion – Swedish" lang="sv" hreflang="sv" data-title="Borreliainfektion" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target">Svenska</a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/%D0%91%D0%BE%D1%80%D1%80%D0%B5%D0%BB%D0%B8%D0%BE%D0%B7" title="Боррелиоз – Tatar" lang="tt" hreflang="tt" data-title="Боррелиоз" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target">Татарча / tatarça</a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B9%84%E0%B8%A5%E0%B8%A1%E0%B9%8C" title="โรคไลม์ – Thai" lang="th" hreflang="th" data-title="โรคไลม์" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target">ไทย</a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Lyme_hastal%C4%B1%C4%9F%C4%B1" title="Lyme hastalığı – Turkish" lang="tr" hreflang="tr" data-title="Lyme hastalığı" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target">Türkçe</a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A5%D0%B2%D0%BE%D1%80%D0%BE%D0%B1%D0%B0_%D0%9B%D0%B0%D0%B9%D0%BC%D0%B0" title="Хвороба Лайма – Ukrainian" lang="uk" hreflang="uk" data-title="Хвороба Лайма" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target">Українська</a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/B%E1%BB%87nh_Lyme" title="Bệnh Lyme – Vietnamese" lang="vi" hreflang="vi" data-title="Bệnh Lyme" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target">Tiếng Việt</a></li><li class="interlanguage-link interwiki-wa mw-list-item"><a href="https://wa.wikipedia.org/wiki/M%C3%A5_d%27_Lyme" title="Må d' Lyme – Walloon" lang="wa" hreflang="wa" data-title="Må d' Lyme" data-language-autonym="Walon" data-language-local-name="Walloon" class="interlanguage-link-target">Walon</a></li><li class="interlanguage-link interwiki-wuu mw-list-item"><a href="https://wuu.wikipedia.org/wiki/%E8%8E%B1%E5%A7%86%E7%97%85" title="莱姆病 – Wu" lang="wuu" hreflang="wuu" data-title="莱姆病" data-language-autonym="吴语" data-language-local-name="Wu" class="interlanguage-link-target">吴语</a></li><li class="interlanguage-link interwiki-zh-yue mw-list-item"><a href="https://zh-yue.wikipedia.org/wiki/%E8%90%8A%E5%A7%86%E7%97%85" title="萊姆病 – Cantonese" lang="yue" hreflang="yue" data-title="萊姆病" data-language-autonym="粵語" data-language-local-name="Cantonese" class="interlanguage-link-target">粵語</a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E8%8E%B1%E5%A7%86%E7%97%85" title="莱姆病 – Chinese" lang="zh" hreflang="zh" data-title="莱姆病" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target">中文</a></li><li class="interlanguage-link interwiki-rsk mw-list-item"><a href="https://rsk.wikipedia.org/wiki/%D0%9B%D0%B0%D0%B9%D0%BC%D1%81%D0%BA%D0%B0_%D1%85%D0%BE%D1%80%D0%BE%D1%82%D0%B0" title="Лаймска хорота – Pannonian Rusyn" lang="rsk" hreflang="rsk" data-title="Лаймска хорота" 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searchaux" style="display:none">Infectious disease caused by Borrelia bacteria, spread by ticks</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Not to be confused with <a href="/wiki/Phytophotodermatitis" title="Phytophotodermatitis">phytophotodermatitis</a>, also known as "lime disease".</div> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Lyme disease</th></tr><tr><th scope="row" class="infobox-label">Other names</th><td class="infobox-data">Lyme borreliosis</td></tr><tr style="background-color: #f8f9fa;"><td colspan="2" class="infobox-full-data"><a href="/wiki/File:Adult_deer_tick.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/34/Adult_deer_tick.jpg/220px-Adult_deer_tick.jpg" decoding="async" width="220" height="247" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/34/Adult_deer_tick.jpg/330px-Adult_deer_tick.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/34/Adult_deer_tick.jpg/440px-Adult_deer_tick.jpg 2x" data-file-width="1322" data-file-height="1485" /></a></td></tr><tr><td colspan="2" class="infobox-full-data">An adult <a href="/wiki/Ixodes_scapularis" title="Ixodes scapularis">deer tick</a> (most cases of Lyme are caused by nymphal rather than adult ticks)</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Infectious_disease_(medical_specialty)" class="mw-redirect" title="Infectious disease (medical specialty)">Infectious disease</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Signs_and_symptoms" title="Signs and symptoms">Symptoms</a></th><td class="infobox-data">Expanding area of redness at the site of a <a href="/wiki/Tick" title="Tick">tick</a> bite, <a href="/wiki/Fever" title="Fever">fever</a>, <a href="/wiki/Headache" title="Headache">headache</a>, <a href="/wiki/Fatigue_(medical)" class="mw-redirect" title="Fatigue (medical)">tiredness</a><a href="#cite_note-CDC2013S-1">[1]</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Complication_(medicine)" title="Complication (medicine)">Complications</a></th><td class="infobox-data"><a href="/wiki/Facial_nerve_paralysis" title="Facial nerve paralysis">Facial nerve paralysis</a>, <a href="/wiki/Arthritis" title="Arthritis">arthritis</a>, <a href="/wiki/Meningitis" title="Meningitis">meningitis-like symptoms</a>,<a href="#cite_note-CDC2024-2">[2]</a> Heart rhythm irregularities<a href="#cite_note-3">[3]</a></td></tr><tr><th scope="row" class="infobox-label">Usual onset</th><td class="infobox-data">A week after a bite<a href="#cite_note-CDC2013S-1">[1]</a></td></tr><tr><th scope="row" class="infobox-label">Causes</th><td class="infobox-data"><a href="/wiki/Borrelia" title="Borrelia">Borrelia</a> spread by ticks<a href="#cite_note-NEJM2014-4">[4]</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_diagnosis" title="Medical diagnosis">Diagnostic method</a></th><td class="infobox-data">Based on symptoms, tick exposure, blood tests<a href="#cite_note-CDC2013Diag-5">[5]</a></td></tr><tr><th scope="row" class="infobox-label">Prevention</th><td class="infobox-data">Prevention of tick bites (clothing the limbs, <a href="/wiki/DEET" title="DEET">DEET</a>), <a href="/wiki/Doxycycline" title="Doxycycline">doxycycline</a><a href="#cite_note-NEJM2014-4">[4]</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medication" title="Medication">Medication</a></th><td class="infobox-data"><a href="/wiki/Doxycycline" title="Doxycycline">Doxycycline</a>, <a href="/wiki/Amoxicillin" title="Amoxicillin">amoxicillin</a>, <a href="/wiki/Ceftriaxone" title="Ceftriaxone">ceftriaxone</a>, <a href="/wiki/Cefuroxime" title="Cefuroxime">cefuroxime</a><a href="#cite_note-NEJM2014-4">[4]</a></td></tr><tr><th scope="row" class="infobox-label">Frequency</th><td class="infobox-data">~476k/year in U.S. (a likely overestimate), 200k/year in Europe<a href="#cite_note-cdc-how-many-6">[6]</a><a href="#cite_note-cdc-estimate-2021-7">[7]</a><a href="#cite_note-comparison-2021-8">[8]</a></td></tr></tbody></table> Lyme disease, also known as Lyme borreliosis, is a <a href="/wiki/Tick-borne_disease" title="Tick-borne disease">tick-borne disease</a> caused by species of <a href="/wiki/Borrelia" title="Borrelia">Borrelia</a> bacteria, <a href="/wiki/Disease_vector" title="Disease vector">transmitted by</a> blood-feeding <a href="/wiki/Ticks" class="mw-redirect" title="Ticks">ticks</a> in the genus <a href="/wiki/Ixodes" title="Ixodes">Ixodes</a>.<a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-NYT-20210611-9">[9]</a><a href="#cite_note-sciencedirect.com-10">[10]</a> The most common sign of infection is an expanding red <a href="/wiki/Rash" title="Rash">rash</a>, known as <a href="/wiki/Erythema_migrans" title="Erythema migrans">erythema migrans</a> (EM), which appears at the site of the tick bite about a week afterwards.<a href="#cite_note-CDC2013S-1">[1]</a> The rash is typically neither itchy nor painful.<a href="#cite_note-CDC2013S-1">[1]</a> Approximately 70–80% of infected people develop a rash.<a href="#cite_note-CDC2013S-1">[1]</a> Early diagnosis can be difficult.<a href="#cite_note-11">[11]</a> Other early symptoms may include fever, headaches and <a href="/wiki/Fatigue_(medical)" class="mw-redirect" title="Fatigue (medical)">tiredness</a>.<a href="#cite_note-CDC2013S-1">[1]</a> If untreated, symptoms may include <a href="/wiki/Facial_nerve_paralysis" title="Facial nerve paralysis">loss of the ability to move one or both sides of the face</a>, <a href="/wiki/Arthritis" title="Arthritis">joint pains</a>, <a href="/wiki/Meningitis" title="Meningitis">severe headaches with neck stiffness</a> or <a href="/wiki/Heart_palpitation" class="mw-redirect" title="Heart palpitation">heart palpitations</a>.<a href="#cite_note-CDC2013S-1">[1]</a> Months to years later, repeated episodes of joint pain and swelling may occur.<a href="#cite_note-CDC2013S-1">[1]</a> Occasionally, shooting pains or tingling in the arms and legs may develop.<a href="#cite_note-CDC2013S-1">[1]</a> Lyme disease is transmitted to humans by the bites of infected ticks of the genus Ixodes.<a href="#cite_note-12">[12]</a> In the United States, ticks of concern are usually of the <a href="/wiki/Ixodes_scapularis" title="Ixodes scapularis">Ixodes scapularis</a> type. According to the <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">Centers for Disease Control and Prevention</a>, "In most cases, a tick must be attached for 36 to 48 hours or more before the Lyme disease bacterium can be transmitted. If you remove a tick quickly (within 24 hours), you can greatly reduce your chances of getting Lyme disease."<a href="#cite_note-CDC2013T-13">[13]</a><a href="#cite_note-Ste2016-14">[14]</a> In Europe, <a href="/wiki/Ixodes_ricinus" title="Ixodes ricinus">Ixodes ricinus</a> ticks may spread the bacteria more quickly.<a href="#cite_note-Ste2016-14">[14]</a><a href="#cite_note-15">[15]</a> In North America, the bacterial species <a href="/wiki/Borrelia_burgdorferi" title="Borrelia burgdorferi">Borrelia burgdorferi</a> and <a href="/wiki/Borrelia_mayonii" title="Borrelia mayonii">B. mayonii</a> cause Lyme disease.<a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-Lancet2016-16">[16]</a> In Europe and Asia, <a href="/wiki/Borrelia_afzelii" title="Borrelia afzelii">Borrelia afzelii</a>, <a href="/wiki/Borrelia_garinii" title="Borrelia garinii">Borrelia garinii</a>, <a href="/wiki/Borrelia_spielmanii" title="Borrelia spielmanii">B. spielmanii</a> and four other species also cause the disease.<a href="#cite_note-NEJM2014-4">[4]</a> The disease does not appear to be transmissible between people, by other animals nor through food.<a href="#cite_note-CDC2013T-13">[13]</a> Diagnosis is based on a combination of symptoms, history of tick exposure and possibly testing for specific <a href="/wiki/Antibodies" class="mw-redirect" title="Antibodies">antibodies</a> in the blood.<a href="#cite_note-CDC2013Diag-5">[5]</a><a href="#cite_note-17">[17]</a> Blood tests are often falsely negative in the early stages of the disease.<a href="#cite_note-NEJM2014-4">[4]</a> Testing of individual ticks is not typically useful.<a href="#cite_note-18">[18]</a> Prevention includes efforts to prevent tick bites by wearing clothing to cover the arms and legs and using <a href="/wiki/DEET" title="DEET">DEET</a> or <a href="/wiki/Picaridin" class="mw-redirect" title="Picaridin">picaridin</a>-based <a href="/wiki/Insect_repellent" title="Insect repellent">insect repellents</a>.<a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-NYT-20210611-9">[9]</a> Using <a href="/wiki/Pesticide" title="Pesticide">pesticides</a> to reduce tick numbers may also be effective.<a href="#cite_note-NEJM2014-4">[4]</a> Ticks can be removed using <a href="/wiki/Tweezer" class="mw-redirect" title="Tweezer">tweezers</a>.<a href="#cite_note-19">[19]</a> If the removed tick is full of blood a single dose of <a href="/wiki/Doxycycline" title="Doxycycline">doxycycline</a> may be used to prevent the development of infection but is not generally recommended since the development of infection is rare.<a href="#cite_note-NEJM2014-4">[4]</a> If an infection develops, a number of antibiotics are effective, including doxycycline, <a href="/wiki/Amoxicillin" title="Amoxicillin">amoxicillin</a> and <a href="/wiki/Cefuroxime" title="Cefuroxime">cefuroxime</a>.<a href="#cite_note-NEJM2014-4">[4]</a> Standard treatment usually lasts for two or three weeks.<a href="#cite_note-NEJM2014-4">[4]</a> Some people develop a fever and muscle and joint pains from treatment, which may last for one or two days.<a href="#cite_note-NEJM2014-4">[4]</a> In those who develop persistent symptoms, long-term antibiotic therapy has not been found to be useful.<a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-CDC2017PT-20">[20]</a> Lyme disease is the most common disease spread by ticks in the Northern Hemisphere.<a href="#cite_note-21">[21]</a><a href="#cite_note-comparison-2021-8">[8]</a> Infections are most common in the spring and early summer.<a href="#cite_note-NEJM2014-4">[4]</a> Lyme disease was diagnosed as a separate condition for the first time in 1975 in <a href="/wiki/Lyme,_Connecticut" title="Lyme, Connecticut">Lyme, Connecticut</a>. It was originally mistaken for <a href="/wiki/Juvenile_idiopathic_arthritis" title="Juvenile idiopathic arthritis">juvenile rheumatoid arthritis</a>.<a href="#cite_note-Car2007-22">[22]</a> The bacterium involved was first described in 1981 by <a href="/wiki/Willy_Burgdorfer" title="Willy Burgdorfer">Willy Burgdorfer</a>.<a href="#cite_note-Tele2014-23">[23]</a> People with persistent symptoms after appropriate treatments are said to have Post-Treatment Lyme Disease Syndrome (PTLDS).<a href="#cite_note-:0-24">[24]</a> PTLDS is different from <a href="/wiki/Chronic_Lyme_disease" title="Chronic Lyme disease">chronic Lyme disease</a>, a term no longer supported by scientists and used in different ways by different groups.<a href="#cite_note-CDC2017PT-20">[20]</a><a href="#cite_note-25">[25]</a> Some healthcare providers claim that chronic Lyme is caused by persistent infection, but this is not believed to be true because no evidence of persistent infection can be found after standard treatment.<a href="#cite_note-Lantos2015-26">[26]</a> As of 2023<a class="external text" href="https://en.wikipedia.org/w/index.php?title=Lyme_disease&action=edit">[update]</a>, clinical trials of proposed human <a href="#Vaccination">vaccines for Lyme disease</a> were being carried out, but no vaccine was available. A vaccine, LYMERix, was produced, but discontinued in 2002 due to insufficient demand.<a href="#cite_note-cdc-vaccine-27">[27]</a> There are several vaccines for the prevention of Lyme disease in dogs. <style data-mw-deduplicate="TemplateStyles:r886046785">.mw-parser-output .toclimit-2 .toclevel-1 ul,.mw-parser-output .toclimit-3 .toclevel-2 ul,.mw-parser-output .toclimit-4 .toclevel-3 ul,.mw-parser-output .toclimit-5 .toclevel-4 ul,.mw-parser-output .toclimit-6 .toclevel-5 ul,.mw-parser-output .toclimit-7 .toclevel-6 ul{display:none}</style><div class="toclimit-3"><meta property="mw:PageProp/toc" /></div> <div class="mw-heading mw-heading2"><h2 id="Signs_and_symptoms">Signs and symptoms</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=1" title="Edit section: Signs and symptoms">edit</a>]</div> Lyme disease can produce a broad range of symptoms. <style data-mw-deduplicate="TemplateStyles:r1248256098">@media all and (max-width:720px){.mw-parser-output .mod-gallery{width:100%!important}}.mw-parser-output .mod-gallery{display:table}.mw-parser-output .mod-gallery-default{background:transparent;margin-top:4px}.mw-parser-output .mod-gallery-center{margin-left:auto;margin-right:auto}.mw-parser-output .mod-gallery-left{float:left}.mw-parser-output .mod-gallery-right{float:right}.mw-parser-output .mod-gallery-none{float:none}.mw-parser-output .mod-gallery-collapsible{width:100%}.mw-parser-output .mod-gallery .title,.mw-parser-output .mod-gallery .main,.mw-parser-output .mod-gallery .footer{display:table-row}.mw-parser-output .mod-gallery .title>div{display:table-cell;padding:0 4px 4px;text-align:center;font-weight:bold}.mw-parser-output .mod-gallery .main>div{display:table-cell}.mw-parser-output .mod-gallery .gallery{line-height:1.35em}.mw-parser-output .mod-gallery .footer>div{display:table-cell;padding:4px;text-align:right;font-size:85%;line-height:1em}.mw-parser-output .mod-gallery .title>div *,.mw-parser-output .mod-gallery .footer>div *{overflow:visible}.mw-parser-output .mod-gallery .gallerybox img{background:none!important}.mw-parser-output .mod-gallery .bordered-images .thumb img{border:solid var(--background-color-neutral,#eaecf0)1px}.mw-parser-output .mod-gallery .whitebg .thumb{background:var(--background-color-base,#fff)!important}</style><div class="mod-gallery mod-gallery-default mod-gallery-right"><div class="main"><div><ul class="gallery mw-gallery-traditional nochecker bordered-images whitebg"> <li class="gallerybox" style="width: 185px"> <div class="thumb" style="width: 180px; height: 210px;"><a href="/wiki/File:Erythema_migrans_-_erythematous_rash_in_Lyme_disease_-_PHIL_9875.jpg" class="mw-file-description" title="20% of Lyme rashes in the United States show a "bull's eye" or "target-like" appearance.[28][29][30]"><img alt="20% of Lyme rashes in the United States show a "bull's eye" or "target-like" appearance.[28][29][30]" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/01/Erythema_migrans_-_erythematous_rash_in_Lyme_disease_-_PHIL_9875.jpg/150px-Erythema_migrans_-_erythematous_rash_in_Lyme_disease_-_PHIL_9875.jpg" decoding="async" width="150" height="176" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/01/Erythema_migrans_-_erythematous_rash_in_Lyme_disease_-_PHIL_9875.jpg/225px-Erythema_migrans_-_erythematous_rash_in_Lyme_disease_-_PHIL_9875.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/01/Erythema_migrans_-_erythematous_rash_in_Lyme_disease_-_PHIL_9875.jpg/300px-Erythema_migrans_-_erythematous_rash_in_Lyme_disease_-_PHIL_9875.jpg 2x" data-file-width="2608" data-file-height="3068" /></a></div> <div class="gallerytext">20% of Lyme rashes in the United States show a "bull's eye" or "target-like" appearance.<a href="#cite_note-wright_2012-28">[28]</a><a href="#cite_note-CDC_Lyme_rashes-29">[29]</a><a href="#cite_note-lyme_rashes_uk-30">[30]</a></div> </li> <li class="gallerybox" style="width: 185px"> <div class="thumb" style="width: 180px; height: 210px;"><a href="/wiki/File:Solid_erythema_migrans_rash_on_the_neck_of_a_woman_with_Lyme_disease.jpg" class="mw-file-description" title="Erythema migrans ("migrating redness") on a woman's neck.[31] Rashes from non-Lyme causes may look similar.[32][33]"><img alt="Erythema migrans ("migrating redness") on a woman's neck.[31] Rashes from non-Lyme causes may look similar.[32][33]" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Solid_erythema_migrans_rash_on_the_neck_of_a_woman_with_Lyme_disease.jpg/150px-Solid_erythema_migrans_rash_on_the_neck_of_a_woman_with_Lyme_disease.jpg" decoding="async" width="150" height="149" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Solid_erythema_migrans_rash_on_the_neck_of_a_woman_with_Lyme_disease.jpg/225px-Solid_erythema_migrans_rash_on_the_neck_of_a_woman_with_Lyme_disease.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/03/Solid_erythema_migrans_rash_on_the_neck_of_a_woman_with_Lyme_disease.jpg/300px-Solid_erythema_migrans_rash_on_the_neck_of_a_woman_with_Lyme_disease.jpg 2x" data-file-width="747" data-file-height="744" /></a></div> <div class="gallerytext"><a href="/wiki/Erythema_migrans" title="Erythema migrans">Erythema migrans</a> ("migrating redness") on a woman's neck.<a href="#cite_note-boyce-31">[31]</a> Rashes from non-Lyme causes may look similar.<a href="#cite_note-tibbles_2007-32">[32]</a><a href="#cite_note-annular-33">[33]</a></div> </li> </ul></div></div></div> The <a href="/wiki/Incubation_period" title="Incubation period">incubation period</a> is usually one to two weeks, but can be much shorter (days) or much longer (months to years).<a href="#cite_note-Lymedisease-34">[34]</a> Lyme symptoms most often occur from the month of May to September in the Northern Hemisphere because the nymphal stage of the tick is responsible for most cases.<a href="#cite_note-Lymedisease-34">[34]</a> <div class="mw-heading mw-heading3"><h3 id="Early_localized_infection">Early localized infection</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=2" title="Edit section: Early localized infection">edit</a>]</div> 80% of Lyme infections begin with a rash of some sort at the site of a tick bite, often near skin folds such as the <a href="/wiki/Armpit" class="mw-redirect" title="Armpit">armpit</a>, <a href="/wiki/Groin" title="Groin">groin</a>, <a href="/wiki/Popliteal_fossa" title="Popliteal fossa">back of the knee</a>, or the <a href="/wiki/Torso" title="Torso">trunk</a> under clothing straps, or in children's hair, ears, or neck.<a href="#cite_note-wright_2012-28">[28]</a><a href="#cite_note-NEJM2014-4">[4]</a> Most people who get infected do not remember seeing a tick or a bite. The rash appears typically one or two weeks (range 3–32 days) after the bite and expands 2–3 cm per day up to a diameter of 5–70 cm (median is 16 cm).<a href="#cite_note-wright_2012-28">[28]</a><a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-tibbles_2007-32">[32]</a> The rash is usually circular or oval, red or bluish, and may have an elevated or darker center.<a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-CDC_Lyme_rashes-29">[29]</a><a href="#cite_note-lyme_rashes_uk-30">[30]</a> This rash is termed an <a href="/wiki/Erythema_migrans" title="Erythema migrans">Erythema Migrans (EM)</a> which translates as "Migrating Redness." In about 79% of cases in Europe, this rash gradually clears from the center toward the edges possibly forming a "bull's eye" or "target-like" pattern, but this clearing only happens in 19% of cases in endemic areas of the United States.<a href="#cite_note-tibbles_2007-32">[32]</a><a href="#cite_note-CDC_Lyme_rashes-29">[29]</a><a href="#cite_note-lyme_rashes_uk-30">[30]</a> The rash may feel warm, usually is not itchy, is rarely tender or painful, and takes up to four weeks to resolve if untreated.<a href="#cite_note-NEJM2014-4">[4]</a> The Lyme rash is often accompanied by symptoms of a flu-like illness, including fatigue, headache, body aches, fever, and chills [though usually neither nausea nor upper-respiratory problems]. These symptoms may also appear without a rash or linger after the rash has disappeared. Lyme can progress to later stages without a rash or these symptoms.<a href="#cite_note-NEJM2014-4">[4]</a> People with high fever for more than two days or whose other symptoms of viral-like illness do not improve despite <a href="/wiki/Antibiotic" title="Antibiotic">antibiotic</a> treatment for Lyme disease, or who have abnormally low levels of <a href="/wiki/Leukopenia" title="Leukopenia">white</a> or <a href="/wiki/Anemia" title="Anemia">red</a> cells or <a href="/wiki/Thrombocytopenia" title="Thrombocytopenia">platelets</a> in the blood, should be investigated for possible coinfection with other <a href="/wiki/Tick-borne_diseases" class="mw-redirect" title="Tick-borne diseases">tick-borne diseases</a> such as <a href="/wiki/Ehrlichiosis" title="Ehrlichiosis">ehrlichiosis</a> and <a href="/wiki/Babesiosis" title="Babesiosis">babesiosis</a>.<a href="#cite_note-idsa_guideline-35">[35]</a> Not everyone with Lyme disease has all the symptoms, and many of these symptoms can also occur with other diseases.<a href="#cite_note-36">[36]</a> <a href="/wiki/Asymptomatic" title="Asymptomatic">Asymptomatic</a> infection exists, but occurs in less than 7% of infected individuals in the United States.<a href="#cite_note-pmid12905137-37">[37]</a> Asymptomatic infection may be much more common among those infected in Europe.<a href="#cite_note-pmid23319969-38">[38]</a> <div class="mw-heading mw-heading3"><h3 id="Early_disseminated_infection">Early disseminated infection</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=3" title="Edit section: Early disseminated infection">edit</a>]</div> Within days to weeks after the onset of local infection, the Borrelia bacteria may spread through the lymphatic system or bloodstream. In 10–20% of untreated cases, EM rashes develop at sites across the body that bear no relation to the original tick bite.<a href="#cite_note-wright_2012-28">[28]</a> Transient <a href="/wiki/Myalgia" title="Myalgia">muscle pains</a> and <a href="/wiki/Arthralgia" title="Arthralgia">joint pains</a> are also common.<a href="#cite_note-wright_2012-28">[28]</a> In about 10–15% of untreated people, Lyme causes neurological problems known as <a href="/wiki/Neuroborreliosis" title="Neuroborreliosis">neuroborreliosis</a>.<a href="#cite_note-Halperin2008-39">[39]</a> Early neuroborreliosis typically appears 4–6 weeks (range 1–12 weeks) after the tick bite and involves some combination of lymphocytic meningitis, cranial neuritis, radiculopathy, and/or mononeuritis multiplex.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-efns_guidelines-40">[40]</a> <a href="/wiki/Aseptic_meningitis" title="Aseptic meningitis">Lymphocytic meningitis</a> causes <a href="/wiki/Lymphocytic_pleocytosis" title="Lymphocytic pleocytosis">characteristic changes</a> in the <a href="/wiki/Cerebrospinal_fluid" title="Cerebrospinal fluid">cerebrospinal fluid</a> (CSF) and may be accompanied for several weeks by variable headache and, less commonly, usually mild <a href="/wiki/Meningism" title="Meningism">meningitis signs</a> such as <a href="/wiki/Neck_stiffness" title="Neck stiffness">inability to flex the neck fully</a> and <a href="/wiki/Photophobia" title="Photophobia">intolerance to bright lights</a> but typically no or only very low fever.<a href="#cite_note-steere_neuro_findings-41">[41]</a> After several months neuroborreliosis can also present <a href="/wiki/Otorhinolaryngology" title="Otorhinolaryngology">otolaryngological symptoms</a>. Up to 76.5% of them present as <a href="/wiki/Tinnitus" title="Tinnitus">tinnitus</a>, the most common symptom. <a href="/wiki/Vertigo" title="Vertigo">Vertigo</a> and dizziness (53.7%) and hearing loss (16.7%) were the next most common symptoms.<a href="#cite_note-42">[42]</a> In children, <a href="/wiki/Papilledema" title="Papilledema">partial loss of vision</a> may also occur.<a href="#cite_note-idsa_guideline-35">[35]</a> Cranial <a href="/wiki/Neuritis" title="Neuritis">neuritis</a> is an inflammation of <a href="/wiki/Cranial_nerves" title="Cranial nerves">cranial nerves</a>. When due to Lyme, it most typically causes <a href="/wiki/Facial_palsy" class="mw-redirect" title="Facial palsy">facial palsy</a>, impairing blinking, smiling, and chewing on one or both sides of the face. It may also cause intermittent <a href="/wiki/Diplopia" title="Diplopia">double vision</a>.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-steere_neuro_findings-41">[41]</a> Lyme <a href="/wiki/Radiculopathy" title="Radiculopathy">radiculopathy</a> is an inflammation of spinal <a href="/wiki/Nerve_root" title="Nerve root">nerve roots</a> that often causes <a href="/wiki/Radiculitis" class="mw-redirect" title="Radiculitis">pain</a> and less often <a href="/wiki/Paresis" title="Paresis">weakness</a>, <a href="/wiki/Hypoesthesia" title="Hypoesthesia">numbness</a>, or <a href="/wiki/Paresthesia" title="Paresthesia">altered sensation</a> in the <a href="/wiki/Dermatome_(anatomy)" title="Dermatome (anatomy)">areas of the body served by nerves connected to the affected roots</a>, e.g. limb(s) or part(s) of trunk. The pain is often described as unlike any other previously felt, excruciating, migrating, worse at night, rarely symmetrical, and often accompanied by extreme sleep disturbance.<a href="#cite_note-efns_guidelines-40">[40]</a><a href="#cite_note-ogrinc_bannwarth-43">[43]</a> <a href="/wiki/Peripheral_neuropathy#Mononeuritis_multiplex" title="Peripheral neuropathy">Mononeuritis multiplex</a> is an inflammation causing similar symptoms in one or more unrelated peripheral nerves.<a href="#cite_note-Halperin2008-39">[39]</a><a href="#cite_note-idsa_guideline-35">[35]</a> Rarely, early neuroborreliosis may involve inflammation of the <a href="/wiki/Encephalitis" title="Encephalitis">brain</a> or <a href="/wiki/Myelitis" title="Myelitis">spinal cord</a>, with symptoms such as confusion, <a href="/wiki/Ataxia" title="Ataxia">abnormal gait, ocular movements, or speech</a>, <a href="/wiki/Paresis" title="Paresis">impaired movement</a>, <a href="/wiki/Apraxia" title="Apraxia">impaired motor planning</a>, or <a href="/wiki/Tremor" title="Tremor">shaking</a>.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-efns_guidelines-40">[40]</a> In North America, facial palsy is the typical early neuroborreliosis presentation, occurring in 5–10% of untreated people, in about 75% of cases accompanied by lymphocytic meningitis.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-garro_2018-44">[44]</a> Lyme radiculopathy is reported half as frequently, but many cases may be unrecognized.<a href="#cite_note-halperin_2010-45">[45]</a> In European adults, the most common presentation is a combination of lymphocytic meningitis and radiculopathy known as <a href="/wiki/Lymphocytic_meningoradiculitis" title="Lymphocytic meningoradiculitis">Bannwarth syndrome</a>, accompanied in 36-89% of cases by facial palsy.<a href="#cite_note-efns_guidelines-40">[40]</a><a href="#cite_note-ogrinc_bannwarth-43">[43]</a> In this syndrome, radicular pain tends to start in the same body region as the initial <a href="/wiki/Erythema_migrans" title="Erythema migrans">erythema migrans</a> rash, if there was one, and precedes possible <a href="/wiki/Facial_palsy" class="mw-redirect" title="Facial palsy">facial palsy</a> and other <a href="/wiki/Paresis" title="Paresis">impaired movement</a>.<a href="#cite_note-ogrinc_bannwarth-43">[43]</a> In extreme cases, permanent <a href="/wiki/Paraparesis" class="mw-redirect" title="Paraparesis">impairment of motor or sensory function</a> of the lower limbs may occur.<a href="#cite_note-pmid23319969-38">[38]</a> In European children, the most common manifestations are facial palsy (in 55%), other cranial neuritis, and lymphocytic meningitis (in 27%).<a href="#cite_note-efns_guidelines-40">[40]</a> In about 4–10% of untreated cases in the United States and 0.3–4% of untreated cases in Europe, typically between June and December, about one month (range 4 days to 7 months) after the tick bite, the infection may cause heart complications known as Lyme <a href="/wiki/Carditis" title="Carditis">carditis</a>.<a href="#cite_note-fish_2008-46">[46]</a><a href="#cite_note-Stanek2012-47">[47]</a> Symptoms may include heart <a href="/wiki/Palpitations" title="Palpitations">palpitations</a> (in 69% of people), <a href="/wiki/Dizziness" title="Dizziness">dizziness</a>, <a href="/wiki/Syncope_(medicine)" title="Syncope (medicine)">fainting</a>, <a href="/wiki/Shortness_of_breath" title="Shortness of breath">shortness of breath</a>, and <a href="/wiki/Chest_pain" title="Chest pain">chest pain</a>.<a href="#cite_note-fish_2008-46">[46]</a> Other symptoms of Lyme disease may also be present, such as <a href="/wiki/Erythema_migrans" title="Erythema migrans">EM</a> rash, <a href="/wiki/Arthralgia" title="Arthralgia">joint aches</a>, <a href="/wiki/Facial_palsy" class="mw-redirect" title="Facial palsy">facial palsy</a>, <a href="/wiki/Headaches" class="mw-redirect" title="Headaches">headaches</a>, or <a href="/wiki/Radiculitis" class="mw-redirect" title="Radiculitis">radicular pain</a>.<a href="#cite_note-fish_2008-46">[46]</a> In some people, however, carditis may be the first manifestation of Lyme disease.<a href="#cite_note-fish_2008-46">[46]</a> Lyme carditis in 19–87% of people adversely impacts the heart's electrical conduction system, causing atrioventricular <a href="/wiki/Heart_block" title="Heart block">block</a> that often manifests as heart rhythms that alternate within minutes between abnormally slow and abnormally fast.<a href="#cite_note-fish_2008-46">[46]</a><a href="#cite_note-Stanek2012-47">[47]</a> In 10–15% of people, Lyme causes <a href="/wiki/Cardiac_muscle" title="Cardiac muscle">myocardial</a> complications such as <a href="/wiki/Cardiomegaly" title="Cardiomegaly">cardiomegaly</a>, left <a href="/wiki/Ventricle_(heart)" title="Ventricle (heart)">ventricular</a> dysfunction, or congestive heart failure.<a href="#cite_note-fish_2008-46">[46]</a> Another skin condition, found in Europe but not in North America, is <a href="/wiki/Borrelial_lymphocytoma" class="mw-redirect" title="Borrelial lymphocytoma">borrelial lymphocytoma</a>, a purplish lump that develops on the ear lobe, nipple, or <a href="/wiki/Scrotum" title="Scrotum">scrotum</a>.<a href="#cite_note-pmid18452805-48">[48]</a> <div class="mw-heading mw-heading3"><h3 id="Late_disseminated_infection"> Late disseminated infection</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=4" title="Edit section: Late disseminated infection">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Right_knee_swelling_caused_by_Lyme_arthritis_in_a_3-year-old_girl.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/02/Right_knee_swelling_caused_by_Lyme_arthritis_in_a_3-year-old_girl.jpg/220px-Right_knee_swelling_caused_by_Lyme_arthritis_in_a_3-year-old_girl.jpg" decoding="async" width="220" height="229" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/02/Right_knee_swelling_caused_by_Lyme_arthritis_in_a_3-year-old_girl.jpg/330px-Right_knee_swelling_caused_by_Lyme_arthritis_in_a_3-year-old_girl.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/02/Right_knee_swelling_caused_by_Lyme_arthritis_in_a_3-year-old_girl.jpg/440px-Right_knee_swelling_caused_by_Lyme_arthritis_in_a_3-year-old_girl.jpg 2x" data-file-width="1148" data-file-height="1197" /></a><figcaption>Lyme arthritis caused this 3-year-old girl's knee to become swollen. Though painless, it did make her limp.<a href="#cite_note-knee-swelling-49">[49]</a></figcaption></figure> Lyme arthritis occurs in up to 60% of untreated people, typically starting about six months after infection.<a href="#cite_note-wright_2012-28">[28]</a> It usually affects only one or a few joints, often a knee or possibly the <a href="/wiki/Hip" title="Hip">hip</a>, other large joints, or the <a href="/wiki/Temporomandibular_joint" title="Temporomandibular joint">temporomandibular joint</a>.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-pmid18452802-50">[50]</a> Usually, large <a href="/wiki/Joint_effusion" title="Joint effusion">joint effusion</a> and swelling occur, but only mild or moderate pain.<a href="#cite_note-idsa_guideline-35">[35]</a> Without treatment, swelling and pain typically resolve over time, but periodically return.<a href="#cite_note-idsa_guideline-35">[35]</a> <a href="/wiki/Baker%27s_cyst" title="Baker's cyst">Baker's cysts</a> may form and rupture. In early US studies of Lyme disease, a rare <a href="/wiki/Peripheral_neuropathy" title="Peripheral neuropathy">peripheral neuropathy</a> was described that included numbness, tingling, or burning starting at the feet or hands and over time possibly moving up the limbs. In a later analysis that discovered poor documentation of this manifestation, experts wondered if it exists at all in the US or is merely very rare.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-axonal-51">[51]</a> A neurologic syndrome called Lyme encephalopathy is associated with subtle memory and cognitive difficulties, <a href="/wiki/Insomnia" title="Insomnia">insomnia</a>, <a href="/wiki/Malaise" title="Malaise">a general sense of feeling unwell</a>, and changes in personality.<a href="#cite_note-MayoClin2008-52">[52]</a> Lyme encephalopathy is controversial in the US and has not been reported in Europe.<a href="#cite_note-comparison-2021-8">[8]</a> Problems such as depression and <a href="/wiki/Fibromyalgia" title="Fibromyalgia">fibromyalgia</a> are as common in people with Lyme disease as in the general population.<a href="#cite_note-Shadick-53">[53]</a><a href="#cite_note-seltzer_2000-54">[54]</a> There is no compelling evidence that Lyme disease causes psychiatric disorders, behavioral disorders (e.g. <a href="/wiki/Attention_deficit_hyperactivity_disorder" title="Attention deficit hyperactivity disorder">ADHD</a>), or developmental disorders (e.g. <a href="/wiki/Autism" title="Autism">autism</a>).<a href="#cite_note-guidelines-2020-55">[55]</a> <a href="/wiki/Acrodermatitis_chronica_atrophicans" title="Acrodermatitis chronica atrophicans">Acrodermatitis chronica atrophicans</a> is a chronic skin disorder observed primarily in Europe among the elderly.<a href="#cite_note-pmid18452805-48">[48]</a> It begins as a reddish-blue patch of discolored skin, often on the backs of the hands or feet. The lesion slowly atrophies over several weeks or months, with the skin becoming first thin and wrinkled and then, if untreated, completely dry and hairless.<a href="#cite_note-mullegger_2004-56">[56]</a> It is also associated with peripheral neuropathy.<a href="#cite_note-axonal-51">[51]</a> <div class="mw-heading mw-heading2"><h2 id="Cause">Cause</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=5" title="Edit section: Cause">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Lyme_disease_microbiology" class="mw-redirect" title="Lyme disease microbiology">Lyme disease microbiology</a></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Further information: <a href="/wiki/Weather_and_climate_effects_on_Lyme_disease_exposure" title="Weather and climate effects on Lyme disease exposure">Weather and climate effects on Lyme disease exposure</a></div> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Borrelia_burgdorferi-cropped.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/15/Borrelia_burgdorferi-cropped.jpg/220px-Borrelia_burgdorferi-cropped.jpg" decoding="async" width="220" height="251" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/15/Borrelia_burgdorferi-cropped.jpg/330px-Borrelia_burgdorferi-cropped.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/1/15/Borrelia_burgdorferi-cropped.jpg 2x" data-file-width="346" data-file-height="395" /></a><figcaption><a href="/wiki/Borrelia" title="Borrelia">Borrelia</a> bacteria, the causative agents of Lyme disease, magnified</figcaption></figure> Lyme disease is caused by <a href="/wiki/Spirochete" class="mw-redirect" title="Spirochete">spirochetes</a>, <a href="/wiki/Gram-negative_bacteria" title="Gram-negative bacteria">gram-negative bacteria</a> from the <a href="/wiki/Genus" title="Genus">genus</a> <a href="/wiki/Borrelia" title="Borrelia">Borrelia</a>. Spirochetes are surrounded by <a href="/wiki/Peptidoglycan" title="Peptidoglycan">peptidoglycan</a> and <a href="/wiki/Flagella" class="mw-redirect" title="Flagella">flagella</a>.<a href="#cite_note-Winslow-57">[57]</a> The Lyme-related Borrelia species are collectively known as <a href="/wiki/Borrelia_burgdorferi" title="Borrelia burgdorferi">Borrelia burgdorferi</a> <a href="/wiki/Sensu_lato" class="mw-redirect" title="Sensu lato">sensu lato</a>, and show a great deal of <a href="/wiki/Genetic_diversity" title="Genetic diversity">genetic diversity</a>.<a href="#cite_note-58">[58]</a> B. burgdorferi sensu lato is a species complex made up of 20 accepted and three proposed genospecies. Eight species are known to cause Lyme disease: B. mayonii (found in North America), B. burgdorferi <a href="/wiki/Sensu_stricto" class="mw-redirect" title="Sensu stricto">sensu stricto</a> (found in North America and Europe), B. afzelii, B. garinii, B. spielmanii, and B. lusitaniae (all found in <a href="/wiki/Eurasia" title="Eurasia">Eurasia</a>).<a href="#cite_note-Cutler2016-59">[59]</a><a href="#cite_note-Stanek2011-60">[60]</a><a href="#cite_note-Lancet2016-16">[16]</a><a href="#cite_note-sciencedirect.com-10">[10]</a> Some studies have also proposed that B. valaisiana may sometimes infect humans, but this species does not seem to be an important cause of disease.<a href="#cite_note-pmid18454594-61">[61]</a><a href="#cite_note-pmid18650352-62">[62]</a> <div class="mw-heading mw-heading3"><h3 id="Tick_life_cycle">Tick life cycle</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=6" title="Edit section: Tick life cycle">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Deer_Tick_life_cycle.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e2/Deer_Tick_life_cycle.svg/220px-Deer_Tick_life_cycle.svg.png" decoding="async" width="220" height="221" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e2/Deer_Tick_life_cycle.svg/330px-Deer_Tick_life_cycle.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e2/Deer_Tick_life_cycle.svg/440px-Deer_Tick_life_cycle.svg.png 2x" data-file-width="354" data-file-height="355" /></a><figcaption>Deer tick life cycle</figcaption></figure> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Ixodes_scapularis.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/88/Ixodes_scapularis.png/220px-Ixodes_scapularis.png" decoding="async" width="220" height="174" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/88/Ixodes_scapularis.png/330px-Ixodes_scapularis.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/88/Ixodes_scapularis.png/440px-Ixodes_scapularis.png 2x" data-file-width="1415" data-file-height="1121" /></a><figcaption><a href="/wiki/Ixodes_scapularis" title="Ixodes scapularis">Ixodes scapularis</a>, the primary vector of Lyme disease in eastern North America</figcaption></figure> Three stages occur in the life cycle of a tick - larva, nymph, and adult. During the nymph stage, ticks most frequently transmit Lyme disease and are usually most active in late spring and early summer in regions where the climate is mild. During the adult stage, Lyme disease transmission is less common because adult ticks are less likely to bite humans and tend to be larger in size, so can be easily seen and removed.<a href="#cite_note-63">[63]</a> <div class="mw-heading mw-heading3"><h3 id="Transmission">Transmission</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=7" title="Edit section: Transmission">edit</a>]</div> Lyme disease is classified as a <a href="/wiki/Zoonosis" title="Zoonosis">zoonosis</a>, as it is <a href="/wiki/Transmission_(medicine)" class="mw-redirect" title="Transmission (medicine)">transmitted</a> to humans from a <a href="/wiki/Natural_reservoir" title="Natural reservoir">natural reservoir</a> among small mammals and birds by <a href="/wiki/Tick" title="Tick">ticks</a> that feed on both sets of <a href="/wiki/Host_(biology)" title="Host (biology)">hosts</a>.<a href="#cite_note-pmid18452798-64">[64]</a> Hard-bodied ticks of the genus Ixodes are the <a href="/wiki/Vector_(epidemiology)" class="mw-redirect" title="Vector (epidemiology)">vectors</a> of Lyme disease (also the vector for <a href="/wiki/Babesia" title="Babesia">Babesia</a>).<a href="#cite_note-Sherris-65">[65]</a> Most infections are caused by ticks in the <a href="/wiki/Nymph_(biology)" title="Nymph (biology)">nymphal stage</a>, because they are very small, thus may feed for long periods of time undetected.<a href="#cite_note-pmid18452798-64">[64]</a> Nymphal ticks are generally the size of a poppy seed and sometimes with a dark head and a translucent body.<a href="#cite_note-Rut2005-66">[66]</a> Or, the nymphal ticks can be darker.<a href="#cite_note-67">[67]</a> The younger larval ticks are very rarely infected.<a href="#cite_note-pmid15117014-68">[68]</a> Although deer are the preferred hosts of adult deer ticks, and tick populations are much lower in the absence of deer, ticks generally do not acquire Borrelia from deer, instead they obtain them from infected small mammals such as the <a href="/wiki/White-footed_mouse" title="White-footed mouse">white-footed mouse</a>, and occasionally birds.<a href="#cite_note-Westport-69">[69]</a> Areas where Lyme is common are expanding.<a href="#cite_note-CDC-Lyme-Data-70">[70]</a> Within the tick midgut, the Borrelia's <a href="/wiki/Lyme_disease_microbiology#Outer_surface_proteins" class="mw-redirect" title="Lyme disease microbiology">outer surface protein</a> A (OspA) binds to the tick receptor for OspA, known as TROSPA. When the tick feeds, the Borrelia <a href="/wiki/Downregulation_and_upregulation" title="Downregulation and upregulation">downregulates</a> OspA and <a href="/wiki/Downregulation_and_upregulation" title="Downregulation and upregulation">upregulates</a> OspC, another surface protein. After the bacteria migrate from the midgut to the salivary glands, OspC binds to Salp15, a tick salivary protein that appears to have immunosuppressive effects that enhance infection.<a href="#cite_note-hovius_2007-71">[71]</a> Successful infection of the mammalian host depends on bacterial expression of OspC.<a href="#cite_note-pmid15085185-72">[72]</a> Tick bites often go unnoticed because of the small size of the tick in its nymphal stage, as well as tick secretions that prevent the host from feeling any itch or pain from the bite. However, transmission is quite rare, with only about 1.2 to 1.4 percent of recognized tick bites resulting in Lyme disease.<a href="#cite_note-73">[73]</a> While <a href="/wiki/Borrelia_burgdorferi" title="Borrelia burgdorferi">B. burgdorferi</a> is most associated with ticks hosted by <a href="/wiki/White-tailed_deer" title="White-tailed deer">white-tailed deer</a> and <a href="/wiki/White-footed_Mouse" class="mw-redirect" title="White-footed Mouse">white-footed mice</a>, <a href="/wiki/Borrelia_afzelii" title="Borrelia afzelii">Borrelia afzelii</a> is most frequently detected in rodent-feeding <a href="/wiki/Disease_vector" title="Disease vector">vector</a> ticks, and <a href="/wiki/Borrelia_garinii" title="Borrelia garinii">Borrelia garinii</a> and <a href="/wiki/Borrelia_valaisiana" title="Borrelia valaisiana">Borrelia valaisiana</a> appear to be associated with birds. Both rodents and birds are competent reservoir hosts for B. burgdorferi sensu stricto. The resistance of a genospecies of Lyme disease <a href="/wiki/Spirochaete" title="Spirochaete">spirochetes</a> to the <a href="/wiki/Bacteriolytic" class="mw-redirect" title="Bacteriolytic">bacteriolytic</a> activities of the alternative complement pathway of various host species may determine its reservoir host association.<a href="#cite_note-pmid16820453-74">[74]</a> Budding research has suggested that B. burgdorferi sensu lato may also be able to form <a href="/wiki/Enzootic" title="Enzootic">enzootic</a> cycle among lizard populations;<a href="#cite_note-pmid17417956-75">[75]</a> this was previously assumed not to be possible in major areas containing populations of lizards, such as California. Except for one study in Europe,<a href="#cite_note-pmid16820453-74">[74]</a> much of the data implicating lizards is based on DNA detection of the spirochete and has not demonstrated that lizards are able to infect ticks feeding upon them.<a href="#cite_note-pmid17417956-75">[75]</a><a href="#cite_note-pmid17626342-76">[76]</a><a href="#cite_note-pmid17427701-77">[77]</a><a href="#cite_note-pmid17326941-78">[78]</a> As some experiments suggest lizards are refractory to infection with Borrelia, it appears likely their involvement in the enzootic cycle is more complex and species-specific.<a href="#cite_note-pmid16995383-79">[79]</a> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Ixodes-ricinus-life-cycle.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/20/Ixodes-ricinus-life-cycle.jpg/220px-Ixodes-ricinus-life-cycle.jpg" decoding="async" width="220" height="157" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/20/Ixodes-ricinus-life-cycle.jpg/330px-Ixodes-ricinus-life-cycle.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/20/Ixodes-ricinus-life-cycle.jpg/440px-Ixodes-ricinus-life-cycle.jpg 2x" data-file-width="2128" data-file-height="1514" /></a><figcaption>Tick <a href="/wiki/Ixodes_ricinus" title="Ixodes ricinus">Ixodes ricinus</a>, developmental stages</figcaption></figure> In Europe, the main vector is <a href="/wiki/Ixodes_ricinus" title="Ixodes ricinus">Ixodes ricinus</a>, which is also called the sheep tick or <a href="/wiki/Castor_oil_plant" class="mw-redirect" title="Castor oil plant">castor bean</a> tick.<a href="#cite_note-de_1997-80">[80]</a> In China, <a href="/wiki/Ixodes_persulcatus" title="Ixodes persulcatus">Ixodes persulcatus</a> (the taiga tick) is probably the most important vector.<a href="#cite_note-Sun_2003-81">[81]</a> In North America, the black-legged tick or deer tick (<a href="/wiki/Ixodes_scapularis" title="Ixodes scapularis">Ixodes scapularis</a>) is the main vector on the East Coast.<a href="#cite_note-pmid15117014-68">[68]</a> The lone star tick (<a href="/wiki/Amblyomma_americanum" title="Amblyomma americanum">Amblyomma americanum</a>), which is found throughout the Southeastern United States as far west as <a href="/wiki/Texas" title="Texas">Texas</a>, is unlikely to transmit the Lyme disease <a href="/wiki/Spirochete" class="mw-redirect" title="Spirochete">spirochetes</a>,<a href="#cite_note-Ledin_2005-82">[82]</a> though it may be implicated in a related syndrome called <a href="/wiki/Southern_tick-associated_rash_illness" title="Southern tick-associated rash illness">southern tick-associated rash illness</a>, which resembles a mild form of Lyme disease.<a href="#cite_note-Masters2008-83">[83]</a> On the <a href="/wiki/West_Coast_of_the_United_States" title="West Coast of the United States">West Coast of the United States</a>, the main vector is the western black-legged tick (<a href="/wiki/Ixodes_pacificus" title="Ixodes pacificus">Ixodes pacificus</a>).<a href="#cite_note-Clark-84">[84]</a> The tendency of this tick species to feed predominantly on host species such as the <a href="/wiki/Western_Fence_Lizard" class="mw-redirect" title="Western Fence Lizard">Western Fence Lizard</a> that are resistant to Borrelia infection appears to diminish transmission of Lyme disease in the West.<a href="#cite_note-pmid15709249-85">[85]</a><a href="#cite_note-pmid16995383-79">[79]</a> Transmission can occur across the <a href="/wiki/Placenta" title="Placenta">placenta</a> during pregnancy and as with a number of other spirochetal diseases, adverse pregnancy outcomes are possible with untreated infection; prompt treatment with antibiotics reduces or eliminates this risk.<a href="#cite_note-Walsh2007-86">[86]</a><a href="#cite_note-Dotters-Katz2013-87">[87]</a><a href="#cite_note-Lakos2010-88">[88]</a><a href="#cite_note-NEJM1989AS-89">[89]</a> There is no scientific evidence to support Lyme disease transmission via blood transfusion, sexual contact, or breast milk.<a href="#cite_note-CDC-FAQ-90">[90]</a> <div class="mw-heading mw-heading3"><h3 id="Tick-borne_co-infections">Tick-borne co-infections</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=8" title="Edit section: Tick-borne co-infections">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Tick-borne_disease" title="Tick-borne disease">Tick-borne disease</a></div> Ticks that transmit B. burgdorferi to humans can also carry and transmit several other microbes, such as <a href="/wiki/Babesia_microti" title="Babesia microti">Babesia microti</a> and <a href="/wiki/Anaplasma_phagocytophilum" title="Anaplasma phagocytophilum">Anaplasma phagocytophilum</a>, which cause the diseases <a href="/wiki/Babesiosis" title="Babesiosis">babesiosis</a> and <a href="/wiki/Human_granulocytic_anaplasmosis" title="Human granulocytic anaplasmosis">human granulocytic anaplasmosis</a> (HGA), respectively.<a href="#cite_note-pmid17041141-91">[91]</a> Among people with early Lyme disease, depending on their location, 2–12% will also have HGA and 2–10% will have babesiosis.<a href="#cite_note-guidelines-2020-55">[55]</a> Ticks in certain regions also transmit viruses that cause <a href="/wiki/Tick-borne_encephalitis" title="Tick-borne encephalitis">tick-borne encephalitis</a> and <a href="/wiki/Powassan_encephalitis" title="Powassan encephalitis">Powassan virus disease</a>.<a href="#cite_note-Lindgren_2001-92">[92]</a><a href="#cite_note-guidelines-2020-55">[55]</a> Co-infections of Lyme disease may not require additional treatment, since they may resolve on their own or—as in the case of HGA—can be treated with the doxycycline prescribed for Lyme.<a href="#cite_note-idsa_guideline-35">[35]</a> Persistent fever or compatible anomalous laboratory findings may be indicative of a co-infection.<a href="#cite_note-guidelines-2020-55">[55]</a> <div class="mw-heading mw-heading2"><h2 id="Pathophysiology">Pathophysiology</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=9" title="Edit section: Pathophysiology">edit</a>]</div> B. burgdorferi can spread throughout the body during the course of the disease, and has been found in the skin, heart, joints, peripheral nervous system, and central nervous system.<a href="#cite_note-pmid15085185-72">[72]</a><a href="#cite_note-pmid17509489-93">[93]</a> B. Burgdorferi does not produce toxins.<a href="#cite_note-ALDF-toxins-94">[94]</a> Therefore, many of the signs and symptoms of Lyme disease are a consequence of the immune response to spirochete in those tissues.<a href="#cite_note-pmid14987414-95">[95]</a> B. burgdorferi is injected into the skin by the bite of an infected Ixodes tick.<a href="#cite_note-Strand-96">[96]</a> Tick saliva, which accompanies the spirochete into the skin during the feeding process, contains substances that disrupt the immune response at the site of the bite.<a href="#cite_note-pmid16698304-97">[97]</a> This provides a protective environment where the spirochete can establish infection. The spirochetes multiply and migrate outward within the <a href="/wiki/Dermis" title="Dermis">dermis</a>. The host inflammatory response to the bacteria in the skin causes the characteristic circular EM lesion.<a href="#cite_note-pmid15085185-72">[72]</a> <a href="/wiki/Neutrophils" class="mw-redirect" title="Neutrophils">Neutrophils</a>, however, which are necessary to eliminate the spirochetes from the skin, fail to appear in necessary numbers in the developing EM lesion because tick saliva inhibits neutrophil function. This allows the bacteria to survive and eventually spread throughout the body.<a href="#cite_note-pmid17404293-98">[98]</a> Days to weeks following the tick bite, the spirochetes spread via the bloodstream to joints, heart, nervous system, and distant skin sites, where their presence gives rise to the variety of symptoms of the disseminated disease. The spread of B. burgdorferi is aided by the attachment of the host protease <a href="/wiki/Plasmin" title="Plasmin">plasmin</a> to the surface of the spirochete.<a href="#cite_note-pmid9215633-99">[99]</a> If untreated, the bacteria may persist in the body for months or even years, despite the production of B. burgdorferi antibodies by the immune system.<a href="#cite_note-pmid11450660-100">[100]</a> The spirochetes may avoid the immune response by decreasing expression of surface proteins that are targeted by antibodies, <a href="/wiki/Antigenic_variation" title="Antigenic variation">antigenic variation</a> of the VlsE surface protein, inactivating key immune components such as <a href="/wiki/Complement_system" title="Complement system">complement</a>, and hiding in the <a href="/wiki/Extracellular_matrix" title="Extracellular matrix">extracellular matrix</a>, which may interfere with the function of immune factors.<a href="#cite_note-pmid18097481-101">[101]</a><a href="#cite_note-pmid17600717-102">[102]</a> <div class="mw-heading mw-heading3"><h3 id="Immunological_studies">Immunological studies</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=10" title="Edit section: Immunological studies">edit</a>]</div> Exposure to the Borrelia bacterium during Lyme disease possibly causes a long-lived and damaging <a href="/wiki/Inflammatory_response" class="mw-redirect" title="Inflammatory response">inflammatory response</a>,<a href="#cite_note-Ercolini-103">[103]</a> a form of pathogen-induced <a href="/wiki/Autoimmune" class="mw-redirect" title="Autoimmune">autoimmune</a> disease.<a href="#cite_note-Singh-104">[104]</a> The production of this reaction might be due to a form of <a href="/wiki/Molecular_mimicry" title="Molecular mimicry">molecular mimicry</a>, where Borrelia avoids being killed by the immune system by resembling normal parts of the body's tissues.<a href="#cite_note-Oldstone_1998-105">[105]</a><a href="#cite_note-Raveche_2005-106">[106]</a> Chronic symptoms from an autoimmune reaction could explain why some symptoms persist even after the spirochetes have been eliminated from the body. This hypothesis may explain why chronic arthritis persists after antibiotic therapy, similar to <a href="/wiki/Rheumatic_fever" title="Rheumatic fever">rheumatic fever</a>, but its wider application is controversial.<a href="#cite_note-Weinstein_2002-107">[107]</a><a href="#cite_note-Bolz_2004-108">[108]</a> <div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=11" title="Edit section: Diagnosis">edit</a>]</div> Lyme disease is <a href="/wiki/Medical_diagnosis" title="Medical diagnosis">diagnosed</a> based on symptoms, objective physical findings (such as <a href="/wiki/Erythema_migrans" title="Erythema migrans">erythema migrans</a> (EM) rash, <a href="/wiki/Facial_palsy" class="mw-redirect" title="Facial palsy">facial palsy</a>, or <a href="/wiki/Arthritis" title="Arthritis">arthritis</a>), history of possible exposure to infected <a href="/wiki/Ticks" class="mw-redirect" title="Ticks">ticks</a>, and possibly <a href="#Laboratory_testing">laboratory tests</a>.<a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-wright_2012-28">[28]</a> People with symptoms of early Lyme disease should have a total body skin examination for EM rashes and asked whether EM-type rashes had manifested within the last 1–2 months.<a href="#cite_note-idsa_guideline-35">[35]</a> Presence of an EM rash and recent tick exposure (i.e., being outdoors in a likely tick habitat where Lyme is <a href="/wiki/Endemic_(epidemiology)" title="Endemic (epidemiology)">common</a>, within 30 days of the appearance of the rash) are sufficient for Lyme diagnosis; no laboratory confirmation is needed or recommended.<a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-wright_2012-28">[28]</a><a href="#cite_note-Brown-109">[109]</a><a href="#cite_note-Hofmann-110">[110]</a> Most people who get infected do not remember a tick or a bite, and the EM rash need not look like a bull's eye (most EM rashes in the U.S. do not) or be accompanied by any other symptoms.<a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-Wormser-111">[111]</a> In the U.S., Lyme is most common in the <a href="/wiki/New_England" title="New England">New England</a> and <a href="/wiki/Mid-Atlantic_(United_States)" title="Mid-Atlantic (United States)">Mid-Atlantic</a> states and parts of <a href="/wiki/Wisconsin" title="Wisconsin">Wisconsin</a> and <a href="/wiki/Minnesota" title="Minnesota">Minnesota</a>, but it is expanding into other areas.<a href="#cite_note-CDC-Lyme-Data-70">[70]</a> Several bordering areas of Canada also have high Lyme risk.<a href="#cite_note-canada_lyme_map-112">[112]</a> In the absence of an EM rash or history of tick exposure, Lyme diagnosis depends on laboratory confirmation.<a href="#cite_note-Sherris-65">[65]</a><a href="#cite_note-aucott_2008-113">[113]</a> The bacteria that cause Lyme disease are difficult to observe directly in body tissues and also difficult and too time-consuming to <a href="/wiki/Microbiological_culture" title="Microbiological culture">grow</a> in the laboratory.<a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-Sherris-65">[65]</a> The most widely used tests look instead for presence of <a href="/wiki/Antibodies" class="mw-redirect" title="Antibodies">antibodies</a> against those bacteria in the blood.<a href="#cite_note-cdc-diagnosis-114">[114]</a> A positive antibody test result does not by itself prove active infection but can confirm an infection that is suspected because of symptoms, objective findings, and history of tick exposure in a person.<a href="#cite_note-Sherris-65">[65]</a> Because as many as 5–20% of the normal population have antibodies against Lyme, people without history and symptoms suggestive of Lyme disease should not be tested for Lyme antibodies: a positive result would likely be false, possibly causing unnecessary treatment.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-efns_guidelines-40">[40]</a> In some cases, when history, signs, and symptoms are strongly suggestive of early disseminated Lyme disease, <a href="/wiki/Empiric_treatment" class="mw-redirect" title="Empiric treatment">empiric treatment</a> may be started and reevaluated as laboratory test results become available.<a href="#cite_note-garro_2018-44">[44]</a><a href="#cite_note-lyme_guidelines_uk-115">[115]</a> <div class="mw-heading mw-heading3"><h3 id="Laboratory_testing">Laboratory testing</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=12" title="Edit section: Laboratory testing">edit</a>]</div> Tests for antibodies in the blood by <a href="/wiki/ELISA" title="ELISA">ELISA</a> and <a href="/wiki/Western_blot" title="Western blot">Western blot</a> is the most widely used method for Lyme diagnosis. A two-tiered protocol is recommended by the <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">Centers for Disease Control and Prevention</a> (CDC): the <a href="/wiki/Sensitivity_and_specificity" title="Sensitivity and specificity">sensitive</a> ELISA test is performed first, and if it is positive or equivocal, then the more <a href="/wiki/Sensitivity_and_specificity" title="Sensitivity and specificity">specific</a> Western blot is run.<a href="#cite_note-Wilske_2005-116">[116]</a> The <a href="/wiki/Immune_system" title="Immune system">immune system</a> takes some time to produce antibodies in quantity. After Lyme infection onset, antibodies of types <a href="/wiki/Immunoglobulin_M" title="Immunoglobulin M">IgM</a> and <a href="/wiki/Immunoglobulin_G" title="Immunoglobulin G">IgG</a> usually can first be detected respectively at 2–4 weeks and 4–6 weeks, and peak at 6–8 weeks.<a href="#cite_note-Depietropaolo-2005-117">[117]</a> When an EM rash first appears, detectable antibodies may not be present. Therefore, it is recommended that testing not be performed and diagnosis be based on the presence of the EM rash.<a href="#cite_note-idsa_guideline-35">[35]</a> Up to 30 days after suspected Lyme infection onset, infection can be confirmed by detection of IgM or IgG antibodies; after that, it is recommended that only IgG antibodies be considered.<a href="#cite_note-Depietropaolo-2005-117">[117]</a> A positive IgM and negative IgG test result after the first month of infection is generally indicative of a false-positive result.<a href="#cite_note-ALDF-serologic-tests-118">[118]</a> The number of IgM antibodies usually collapses 4–6 months after infection, while IgG antibodies can remain detectable for years.<a href="#cite_note-Depietropaolo-2005-117">[117]</a> Other tests may be used in neuroborreliosis cases. In Europe, neuroborreliosis is usually caused by <a href="/wiki/Borrelia_garinii" title="Borrelia garinii">Borrelia garinii</a> and almost always involves <a href="/wiki/Lymphocytic_pleocytosis" title="Lymphocytic pleocytosis">lymphocytic pleocytosis</a>, i.e. the densities of <a href="/wiki/Lymphocytes" class="mw-redirect" title="Lymphocytes">lymphocytes</a> (infection-fighting cells) and protein in the <a href="/wiki/Cerebrospinal_fluid" title="Cerebrospinal fluid">cerebrospinal fluid</a> (CSF) typically rise to characteristically abnormal levels, while glucose level remains normal.<a href="#cite_note-steere_neuro_findings-41">[41]</a><a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-ogrinc_bannwarth-43">[43]</a> Additionally, the immune system produces antibodies against Lyme inside the intrathecal space, which contains the CSF.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-ogrinc_bannwarth-43">[43]</a> Demonstration by <a href="/wiki/Lumbar_puncture" title="Lumbar puncture">lumbar puncture</a> and CSF analysis of pleocytosis and intrathecal antibody production are required for definite diagnosis of neuroborreliosis in Europe (except in cases of peripheral neuropathy associated with <a href="/wiki/Acrodermatitis_chronica_atrophicans" title="Acrodermatitis chronica atrophicans">acrodermatitis chronica atrophicans</a>, which usually is caused by <a href="/wiki/Borrelia_afzelii" title="Borrelia afzelii">Borrelia afzelii</a> and confirmed by blood antibody tests).<a href="#cite_note-efns_guidelines-40">[40]</a> In North America, neuroborreliosis is caused by <a href="/wiki/Borrelia_burgdorferi" title="Borrelia burgdorferi">Borrelia burgdorferi</a> and may not be accompanied by the same CSF signs; they confirm a diagnosis of central nervous system (CNS) neuroborreliosis if positive, but do not exclude it if negative.<a href="#cite_note-Coyle_1995-119">[119]</a> American guidelines consider CSF analysis optional when symptoms appear to be confined to the peripheral nervous system (PNS), e.g. facial palsy without overt meningitis symptoms.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-pmid17522387-120">[120]</a> Unlike blood and intrathecal antibody tests, CSF pleocytosis tests revert to normal after infection ends and therefore can be used as objective markers of treatment success and inform decisions on whether to retreat.<a href="#cite_note-ogrinc_bannwarth-43">[43]</a> In infection involving the PNS, <a href="/wiki/Electromyography" title="Electromyography">electromyography</a> and <a href="/wiki/Nerve_conduction_studies" class="mw-redirect" title="Nerve conduction studies">nerve conduction studies</a> can be used to monitor objectively the response to treatment.<a href="#cite_note-steere_neuro_findings-41">[41]</a> In Lyme carditis, <a href="/wiki/Electrocardiography" title="Electrocardiography">electrocardiograms</a> are used to evidence heart conduction abnormalities, while <a href="/wiki/Echocardiography" title="Echocardiography">echocardiography</a> may show <a href="/wiki/Cardiac_muscle" title="Cardiac muscle">myocardial</a> dysfunction.<a href="#cite_note-fish_2008-46">[46]</a> <a href="/wiki/Biopsy" title="Biopsy">Biopsy</a> and confirmation of Borrelia cells in myocardial tissue may be used in specific cases but are usually not done because of risk of the procedure.<a href="#cite_note-fish_2008-46">[46]</a> <a href="/wiki/Polymerase_chain_reaction" title="Polymerase chain reaction">Polymerase chain reaction</a> (PCR) tests for Lyme disease have also been developed to detect the genetic material (<a href="/wiki/DNA" title="DNA">DNA</a>) of the Lyme disease spirochete. Culture or PCR are the current means for detecting the presence of the organism, as <a href="/wiki/Serology" title="Serology">serologic</a> studies only test for <a href="/wiki/Antibodies" class="mw-redirect" title="Antibodies">antibodies</a> of Borrelia. PCR has the advantage of being much faster than culture. However, PCR tests are susceptible to <a href="/wiki/Type_I_and_type_II_errors" title="Type I and type II errors">false positive</a> results, e.g. by detection of debris of dead Borrelia cells or specimen contamination.<a href="#cite_note-pmid11438915-121">[121]</a><a href="#cite_note-efns_guidelines-40">[40]</a> Even when properly performed, PCR often shows false-negative results because few Borrelia cells can be found in blood and <a href="/wiki/Cerebrospinal_fluid" title="Cerebrospinal fluid">cerebrospinal fluid</a> (CSF) during infection.<a href="#cite_note-pmid16020686-122">[122]</a><a href="#cite_note-efns_guidelines-40">[40]</a> Hence, PCR tests are recommended only in special cases, e.g. diagnosis of Lyme arthritis, because it is a highly sensitive way of detecting ospA DNA in synovial fluid.<a href="#cite_note-pmid8272083-123">[123]</a> Although sensitivity of PCR in CSF is low, its use may be considered when intrathecal antibody production test results are suspected of being falsely negative, e.g. in very early (< 6 weeks) neuroborreliosis or in <a href="/wiki/Immunosuppression" title="Immunosuppression">immunosuppressed</a> people.<a href="#cite_note-efns_guidelines-40">[40]</a> Several other forms of laboratory testing for Lyme disease are available, some of which have not been adequately validated. <a href="/wiki/Lyme_disease_microbiology" class="mw-redirect" title="Lyme disease microbiology">OspA antigens</a>, shed by live Borrelia bacteria into urine, are a promising technique being studied.<a href="#cite_note-124">[124]</a> The use of nanotrap particles for their detection is being looked at and the OspA has been linked to active symptoms of Lyme.<a href="#cite_note-125">[125]</a><a href="#cite_note-126">[126]</a> High <a href="/wiki/Titer" title="Titer">titers</a> of either immunoglobulin G (IgG) or immunoglobulin M (IgM) antibodies to Borrelia antigens indicate disease, but lower titers can be misleading, because the IgM antibodies may remain after the initial infection, and IgG antibodies may remain for years.<a href="#cite_note-Burdash_1991-127">[127]</a> The CDC does not recommend urine antigen tests, PCR tests on urine, immunofluorescent staining for cell-wall-deficient forms of B. burgdorferi, and lymphocyte transformation tests.<a href="#cite_note-pmid16020686-122">[122]</a> <div class="mw-heading mw-heading3"><h3 id="Imaging">Imaging</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=13" title="Edit section: Imaging">edit</a>]</div> <a href="/wiki/Neuroimaging" title="Neuroimaging">Neuroimaging</a> is controversial in whether it provides specific patterns unique to <a href="/wiki/Neuroborreliosis" title="Neuroborreliosis">neuroborreliosis</a>, but may aid in <a href="/wiki/Differential_diagnosis" title="Differential diagnosis">differential diagnosis</a> and in understanding the pathophysiology of the disease.<a href="#cite_note-Hildenbrand2009-128">[128]</a> Though controversial, some evidence shows certain neuroimaging tests can provide data that are helpful in the diagnosis of a person. <a href="/wiki/Magnetic_resonance_imaging" title="Magnetic resonance imaging">Magnetic resonance imaging</a> (MRI) and <a href="/wiki/Single-photon_emission_computed_tomography" title="Single-photon emission computed tomography">single-photon emission computed tomography</a> (SPECT) are two of the tests that can identify abnormalities in the brain of a person affected with this disease. Neuroimaging findings in an MRI include lesions in the periventricular white matter, as well as enlarged ventricles and cortical atrophy. The findings are considered somewhat unexceptional because the lesions have been found to be reversible following antibiotic treatment. Images produced using SPECT show numerous areas where an insufficient amount of blood is being delivered to the cortex and subcortical white matter. However, SPECT images are known to be nonspecific because they show a heterogeneous pattern in the imaging. The abnormalities seen in the SPECT images are very similar to those seen in people with cerebral vasculitis and <a href="/wiki/Creutzfeldt%E2%80%93Jakob_disease" title="Creutzfeldt–Jakob disease">Creutzfeldt–Jakob disease</a>, which makes them questionable.<a href="#cite_note-129">[129]</a> <div class="mw-heading mw-heading3"><h3 id="Differential_diagnosis">Differential diagnosis</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=14" title="Edit section: Differential diagnosis">edit</a>]</div> Community clinics have been reported to misdiagnose 23–28% of <a href="/wiki/Erythema_migrans" title="Erythema migrans">Erythema migrans</a> (EM) rashes and 83% of other objective manifestations of early Lyme disease.<a href="#cite_note-aucott_2008-113">[113]</a> EM rashes are often misdiagnosed as <a href="/wiki/Spider_bites" class="mw-redirect" title="Spider bites">spider bites</a>, <a href="/wiki/Cellulitis" title="Cellulitis">cellulitis</a>, or <a href="/wiki/Shingles" title="Shingles">shingles</a>.<a href="#cite_note-aucott_2008-113">[113]</a> Many misdiagnoses are credited to the widespread misconception that EM rashes should look like a bull's eye.<a href="#cite_note-NEJM2014-4">[4]</a> Actually, the key distinguishing features of the EM rash are the speed and extent to which it expands, respectively up to 2–3 cm/day and a diameter of at least 5 cm, and in 50% of cases more than 16 cm. The rash expands away from its center, which may or may not look different or be separated by ring-like clearing from the rest of the rash.<a href="#cite_note-wright_2012-28">[28]</a><a href="#cite_note-tibbles_2007-32">[32]</a> Compared to EM rashes, <a href="/wiki/Spider_bites" class="mw-redirect" title="Spider bites">spider bites</a> are more common in the limbs, tend to be more painful and itchy or become swollen, and some may cause <a href="/wiki/Necrosis" title="Necrosis">necrosis</a> (sinking dark blue patch of dead skin).<a href="#cite_note-wright_2012-28">[28]</a><a href="#cite_note-NEJM2014-4">[4]</a> <a href="/wiki/Cellulitis" title="Cellulitis">Cellulitis</a> most commonly develops around a wound or ulcer, is rarely circular, and is more likely to become swollen and tender.<a href="#cite_note-wright_2012-28">[28]</a><a href="#cite_note-NEJM2014-4">[4]</a> EM rashes often appear at sites that are unusual for cellulitis, such as the armpit, groin, abdomen, or back of knee.<a href="#cite_note-wright_2012-28">[28]</a> Like Lyme, <a href="/wiki/Shingles" title="Shingles">shingles</a> often begins with headache, fever, and fatigue, which are followed by pain or numbness. However, unlike Lyme, in shingles these symptoms are usually followed by appearance of rashes composed of multiple small blisters along with a nerve's <a href="/wiki/Dermatome_(anatomy)" title="Dermatome (anatomy)">dermatome</a>, and shingles can also be confirmed by quick laboratory tests.<a href="#cite_note-Dwo2007-130">[130]</a> <a href="/wiki/Facial_palsy" class="mw-redirect" title="Facial palsy">Facial palsy</a> caused by Lyme disease (LDFP) is often misdiagnosed as <a href="/wiki/Bell%27s_palsy" title="Bell's palsy">Bell's palsy</a>.<a href="#cite_note-garro_2018-44">[44]</a> Although Bell's palsy is the most common type of one-sided facial palsy (about 70% of cases), LDFP can account for about 25% of cases of facial palsy in areas where Lyme disease is common.<a href="#cite_note-garro_2018-44">[44]</a> Compared to LDFP, Bell's palsy much less frequently affects both sides of the face.<a href="#cite_note-garro_2018-44">[44]</a> Even though LDFP and Bell's palsy have similar symptoms and evolve similarly if untreated, corticosteroid treatment is beneficial for Bell's Palsy, while being detrimental for LDFP.<a href="#cite_note-garro_2018-44">[44]</a> Recent history of exposure to a likely tick habitat during warmer months, EM rash, viral-like symptoms such as headache and fever, and/or palsy in both sides of the face should be evaluated for the likelihood of LDFP; if it is more than minimal, <a href="/wiki/Empiric_therapy" title="Empiric therapy">empiric therapy</a> with antibiotics should be initiated, without corticosteroids, and reevaluated upon completion of laboratory tests for Lyme disease.<a href="#cite_note-garro_2018-44">[44]</a> Unlike <a href="/wiki/Viral_meningitis" title="Viral meningitis">viral meningitis</a>, Lyme lymphocytic meningitis tends to not cause fever, last longer, and recur.<a href="#cite_note-steere_neuro_findings-41">[41]</a><a href="#cite_note-idsa_guideline-35">[35]</a> Lymphocytic meningitis is also characterized by possibly co-occurring with <a href="/wiki/Erythema_migrans" title="Erythema migrans">EM rash</a>, <a href="/wiki/Facial_palsy" class="mw-redirect" title="Facial palsy">facial palsy</a>, or <a href="/wiki/Papilledema" title="Papilledema">partial vision obstruction</a> and having much lower percentage of polymorphonuclear leukocytes in <a href="/wiki/Cerebrospinal_fluid" title="Cerebrospinal fluid">CSF</a>.<a href="#cite_note-idsa_guideline-35">[35]</a> Lyme radiculopathy affecting the limbs is often misdiagnosed as a <a href="/wiki/Radiculopathy" title="Radiculopathy">radiculopathy</a> caused by nerve root compression, such as <a href="/wiki/Sciatica" title="Sciatica">sciatica</a>.<a href="#cite_note-aucott_2008-113">[113]</a><a href="#cite_note-halperin_chronic-131">[131]</a> Although most cases of radiculopathy are compressive and resolve with conservative treatment (e.g., rest) within 4–6 weeks, guidelines for managing radiculopathy recommend first evaluating risks of other possible causes that, although less frequent, require immediate diagnosis and treatment, including infections such as Lyme and shingles.<a href="#cite_note-tarulli_radiculopathy-132">[132]</a> A history of outdoor activities in likely tick habitats in the last 3 months possibly followed by a rash or viral-like symptoms, and current headache, other symptoms of lymphocytic meningitis, or facial palsy would lead to suspicion of Lyme disease and recommendation of <a href="/wiki/Serology" title="Serology">serological</a> and <a href="/wiki/Lumbar_puncture" title="Lumbar puncture">lumbar puncture</a> tests for confirmation.<a href="#cite_note-tarulli_radiculopathy-132">[132]</a> Lyme radiculopathy affecting the trunk can be misdiagnosed as myriad other conditions, such as <a href="/wiki/Diverticulitis" title="Diverticulitis">diverticulitis</a> and <a href="/wiki/Acute_coronary_syndrome" title="Acute coronary syndrome">acute coronary syndrome</a>.<a href="#cite_note-halperin_2010-45">[45]</a><a href="#cite_note-aucott_2008-113">[113]</a> Diagnosis of late-stage Lyme disease is often complicated by a multifaceted appearance and nonspecific symptoms, prompting one reviewer to call Lyme the new "great imitator".<a href="#cite_note-Pachner_1989-133">[133]</a> As all people with later-stage infection will have a positive antibody test, simple blood tests can exclude Lyme disease as a possible cause of a person's symptoms.<a href="#cite_note-Branda_541–7-134">[134]</a> <div class="mw-heading mw-heading2"><h2 id="Prevention">Prevention</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=15" title="Edit section: Prevention">edit</a>]</div> Tick bites may be prevented by avoiding or reducing time in likely tick habitats and taking precautions while in and when getting out of one.<a href="#cite_note-CDC_Lyme_prev_on_people-135">[135]</a><a href="#cite_note-NYT-20210611-9">[9]</a> Most Lyme human infections are caused by <a href="/wiki/Ixodes" title="Ixodes">Ixodes</a> nymph bites between April and September.<a href="#cite_note-wright_2012-28">[28]</a><a href="#cite_note-CDC_Lyme_prev_on_people-135">[135]</a> Ticks prefer moist, shaded locations in <a href="/wiki/Woodland" title="Woodland">woodlands</a>, shrubs, tall grasses and <a href="/wiki/Leaf_litter" class="mw-redirect" title="Leaf litter">leaf litter</a> or wood piles.<a href="#cite_note-wright_2012-28">[28]</a><a href="#cite_note-CVBD_tick_preventative-136">[136]</a> Tick densities tend to be highest in woodlands, followed by unmaintained <a href="/wiki/Ecotone" title="Ecotone">edges between woods and lawns</a> (about half as high), ornamental plants and perennial <a href="/wiki/Groundcover" title="Groundcover">groundcover</a> (about a quarter), and lawns (about 30 times less).<a href="#cite_note-eisen_2016-137">[137]</a> Ixodes <a href="/wiki/Larva" title="Larva">larvae</a> and nymphs tend to be abundant also where mice nest, such as <a href="/wiki/Dry_stone" title="Dry stone">stone walls</a> and wood logs.<a href="#cite_note-eisen_2016-137">[137]</a> Ixodes larvae and nymphs typically wait for potential <a href="/wiki/Host_(biology)" title="Host (biology)">hosts</a> ("quest") on leaves or grasses close to the ground with forelegs outstretched; when a host brushes against its limbs, the tick rapidly clings and climbs on the host looking for a skin location to bite.<a href="#cite_note-CVBDhost-138">[138]</a> In Northeastern United States, 69% of tick bites are estimated to happen in residences, 11% in schools or camps, 9% in parks or recreational areas, 4% at work, 3% while hunting, and 4% in other areas.<a href="#cite_note-eisen_2016-137">[137]</a> Activities associated with tick bites around residences include yard work, brush clearing, gardening, playing in the yard, and letting dogs or cats that roam outside in woody or grassy areas into the house.<a href="#cite_note-eisen_2016-137">[137]</a><a href="#cite_note-CDC_Lyme_prev_on_people-135">[135]</a> In parks, tick bites often happen while hiking or camping.<a href="#cite_note-eisen_2016-137">[137]</a> Walking on a mown lawn or center of a trail without touching adjacent vegetation is less risky than crawling or sitting on a log or stone wall.<a href="#cite_note-eisen_2016-137">[137]</a><a href="#cite_note-EPA_tick_prevention-139">[139]</a> Pets should not be allowed to roam freely in likely tick habitats.<a href="#cite_note-CVBD_tick_preventative-136">[136]</a> As a precaution, <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">CDC</a> recommends soaking or spraying clothes, shoes, and camping gear such as tents, backpacks and sleeping bags with 0.5% <a href="/wiki/Permethrin" title="Permethrin">permethrin</a> solution and hanging them to dry before use.<a href="#cite_note-CDC_Lyme_prev_on_people-135">[135]</a><a href="#cite_note-CDC_travelers_protection-140">[140]</a> Permethrin is odorless and safe for humans but highly toxic to ticks.<a href="#cite_note-miller_2011-141">[141]</a> After crawling on permethrin-treated fabric for as few as 10–20 seconds, tick nymphs become irritated and fall off or die.<a href="#cite_note-miller_2011-141">[141]</a><a href="#cite_note-eisen_2017-142">[142]</a> Permethrin-treated closed-toed shoes and socks reduce by 74 times the number of bites from nymphs that make first contact with a shoe of a person also wearing treated shorts (because nymphs usually quest near the ground, this is a typical contact scenario).<a href="#cite_note-miller_2011-141">[141]</a> Better protection can be achieved by tucking permethrin-treated trousers (pants) into treated socks and a treated long-sleeve shirt into the trousers so as to minimize gaps through which a tick might reach the wearer's skin.<a href="#cite_note-EPA_tick_prevention-139">[139]</a> Light-colored clothing may make it easier to see ticks and remove them before they bite.<a href="#cite_note-EPA_tick_prevention-139">[139]</a> Military and outdoor workers' uniforms treated with permethrin have been found to reduce the number of bite cases by 80–95%.<a href="#cite_note-eisen_2017-142">[142]</a> Permethrin protection lasts several weeks of wear and washings in customer-treated items and up to 70 washings for factory-treated items.<a href="#cite_note-CDC_travelers_protection-140">[140]</a> Permethrin should not be used on human skin, underwear or cats.<a href="#cite_note-CDC_travelers_protection-140">[140]</a><a href="#cite_note-dymond_2008-143">[143]</a> The <a href="/wiki/United_States_Environmental_Protection_Agency" title="United States Environmental Protection Agency">EPA</a> recommends several tick <a href="/wiki/Insect_repellent" title="Insect repellent">repellents</a> for use on exposed skin, including <a href="/wiki/DEET" title="DEET">DEET</a>, <a href="/wiki/Picaridin" class="mw-redirect" title="Picaridin">picaridin</a>, <a href="/wiki/IR3535" class="mw-redirect" title="IR3535">IR3535</a> (a derivative of amino acid beta-alanine), <a href="/wiki/Eucalyptus_oil" title="Eucalyptus oil">oil of lemon eucalyptus</a> (OLE, a natural compound) and OLE's active ingredient <a href="/wiki/P-Menthane-3,8-diol" title="P-Menthane-3,8-diol">para-menthane-diol (PMD)</a>.<a href="#cite_note-CDC_Lyme_prev_on_people-135">[135]</a><a href="#cite_note-EPA_insect_repellents-144">[144]</a><a href="#cite_note-nguyen_2018-145">[145]</a> Unlike permethrin, repellents repel but do not kill ticks, protect for only several hours after application, and may be washed off by sweat or water.<a href="#cite_note-CDC_travelers_protection-140">[140]</a> The most popular repellent is DEET in the U.S. and picaridin in Europe.<a href="#cite_note-nguyen_2018-145">[145]</a> Unlike DEET, picaridin is odorless and is less likely to irritate the skin or harm fabric or plastics.<a href="#cite_note-nguyen_2018-145">[145]</a> Repellents with higher concentration may last longer but are not more effective; against ticks, 20% picaridin may work for 8 hours vs. 55–98.11% DEET for 5–6 hours or 30–40% OLE for 6 hours.<a href="#cite_note-CDC_travelers_protection-140">[140]</a><a href="#cite_note-EPA_insect_repellents-144">[144]</a> Repellents should not be used under clothes, on eyes, mouth, wounds or cuts, or on babies younger than 2 months (3 years for OLE or PMD).<a href="#cite_note-CDC_travelers_protection-140">[140]</a><a href="#cite_note-CDC_Lyme_prev_on_people-135">[135]</a> If <a href="/wiki/Sunscreen" title="Sunscreen">sunscreen</a> is used, repellent should be applied on top of it.<a href="#cite_note-CDC_travelers_protection-140">[140]</a> Repellents should not be sprayed directly on a face, but should instead be sprayed on a hand and then rubbed on the face.<a href="#cite_note-CDC_travelers_protection-140">[140]</a> After coming indoors, clothes, gear and pets should be checked for ticks.<a href="#cite_note-CDC_Lyme_prev_on_people-135">[135]</a> Clothes can be put into a hot dryer for 10 minutes to kill ticks (just washing or warm dryer are not enough).<a href="#cite_note-CDC_Lyme_prev_on_people-135">[135]</a> Showering as soon as possible, looking for ticks over the entire body, and removing them reduce risk of infection.<a href="#cite_note-CDC_Lyme_prev_on_people-135">[135]</a> Unfed tick nymphs are the size of a poppy seed, but a day or two after biting and attaching themselves to a person, they look like a small <a href="/wiki/Blood_blister" title="Blood blister">blood blister</a>.<a href="#cite_note-CT_tick-management-146">[146]</a> The following areas should be checked especially carefully: armpits, between legs, back of knee, bellybutton, trunk, and in children ears, neck and hair.<a href="#cite_note-CDC_Lyme_prev_on_people-135">[135]</a> <div class="mw-heading mw-heading3"><h3 id="Tick_removal">Tick removal</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=16" title="Edit section: Tick removal">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Tickremoval.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f1/Tickremoval.svg/220px-Tickremoval.svg.png" decoding="async" width="220" height="121" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f1/Tickremoval.svg/330px-Tickremoval.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f1/Tickremoval.svg/440px-Tickremoval.svg.png 2x" data-file-width="513" data-file-height="282" /></a><figcaption>Removal of a tick using tweezers</figcaption></figure> Attached ticks should be removed promptly. Risk of infection increases with time of attachment, but in North America risk of Lyme disease is small if the tick is removed within 36 hours.<a href="#cite_note-piesman2002-147">[147]</a> <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">CDC</a> recommends inserting a fine-tipped tweezer between the skin and the tick, grasping very firmly, and pulling the closed tweezer straight away from the skin without twisting, jerking, squeezing or crushing the tick.<a href="#cite_note-CDC_tick_removal-148">[148]</a> After tick removal, any tick parts remaining in the skin should be removed with a clean tweezer, if possible.<a href="#cite_note-CDC_tick_removal-148">[148]</a> The wound and hands should then be cleaned with alcohol or soap and water.<a href="#cite_note-CDC_tick_removal-148">[148]</a> The tick may be disposed by placing it in a container with alcohol, sealed bag, tape or flushed down the toilet.<a href="#cite_note-CDC_tick_removal-148">[148]</a> The bitten person should write down where and when the bite happened so that this can be informed to a doctor if the person gets a rash or flu-like symptoms in the following several weeks.<a href="#cite_note-CDC_tick_removal-148">[148]</a> CDC recommends not using fingers, nail polish, petroleum jelly or heat on the tick to try to remove it.<a href="#cite_note-CDC_tick_removal-148">[148]</a> In Australia, where the <a href="/wiki/Ixodes_holocyclus" title="Ixodes holocyclus">Australian paralysis tick</a> is prevalent, the <a href="/wiki/Australasian_Society_of_Clinical_Immunology_and_Allergy" title="Australasian Society of Clinical Immunology and Allergy">Australasian Society of Clinical Immunology and Allergy</a> recommends not using tweezers to remove ticks, because if the person is allergic, <a href="/wiki/Anaphylaxis" title="Anaphylaxis">anaphylaxis</a> could result.<a href="#cite_note-australia_tick_freeze-149">[149]</a> Instead, a product should be sprayed on the tick to cause it to freeze and then drop off.<a href="#cite_note-australia_tick_freeze-149">[149]</a> Another method consists in using about 20 cm of dental floss or fishing line for slowly tying an overhand knot between the skin and the tick and then pulling it away from the skin.<a href="#cite_note-150">[150]</a><a href="#cite_note-151">[151]</a> <div class="mw-heading mw-heading3"><h3 id="Preventive_antibiotics">Preventive antibiotics</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=17" title="Edit section: Preventive antibiotics">edit</a>]</div> The risk of infectious transmission increases with the duration of tick attachment.<a href="#cite_note-wright_2012-28">[28]</a> It requires between 36 and 48 hours of attachment for the bacteria that causes Lyme to travel from within the tick into its saliva.<a href="#cite_note-wright_2012-28">[28]</a> If a deer tick that is sufficiently likely to be carrying Borrelia is found attached to a person and removed, and if the tick has been attached for 36 hours or is engorged, a single dose of doxycycline administered within the 72 hours after removal may reduce the risk of Lyme disease. It is not generally recommended for all people bitten, as development of infection is rare: about 50 bitten people would have to be treated this way to prevent one case of erythema migrans (i.e. the typical rash found in about 70–80% of people infected).<a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-wright_2012-28">[28]</a> <div class="mw-heading mw-heading3"><h3 id="Garden_landscaping">Garden landscaping</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=18" title="Edit section: Garden landscaping">edit</a>]</div> Several landscaping practices may reduce the risk of tick bites in residential yards.<a href="#cite_note-CT_tick-management-146">[146]</a><a href="#cite_note-CDC_Lyme_prev_in_yard-152">[152]</a> These include keeping lawns mown, removing <a href="/wiki/Leaf_litter" class="mw-redirect" title="Leaf litter">leaf litter</a> and weeds and avoiding the use of ground cover.<a href="#cite_note-CT_tick-management-146">[146]</a> A 3-ft-wide rock or woodchip barrier is recommended to separate lawns from wood piles, <a href="/wiki/Woodland" title="Woodland">woodlands</a>, <a href="/wiki/Dry_stone" title="Dry stone">stone walls</a> and shrubs.<a href="#cite_note-CDC_Lyme_prev_in_yard-152">[152]</a> Without vegetation on the barrier, ticks will tend not to cross it; <a href="/wiki/Acaricides" class="mw-redirect" title="Acaricides">acaricides</a> may also be sprayed on it to kill ticks.<a href="#cite_note-CDC_Lyme_prev_in_yard-152">[152]</a> A sun-exposed tick-safe zone at least 9 ft from the barrier should concentrate human activity on the yard, including any patios, playgrounds and gardening.<a href="#cite_note-CDC_Lyme_prev_in_yard-152">[152]</a> Materials such as wood decking, concrete, bricks, gravel or woodchips used on the ground under patios and playgrounds would discourage ticks there.<a href="#cite_note-CT_tick-management-146">[146]</a> An 8-ft-high fence may be added to keep deer away from the tick-safe zone.<a href="#cite_note-CDC_Lyme_prev_in_yard-152">[152]</a><a href="#cite_note-CT_tick-management-146">[146]</a> <div class="mw-heading mw-heading3"><h3 id="Occupational_exposure">Occupational exposure</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=19" title="Edit section: Occupational exposure">edit</a>]</div> Outdoor workers are at risk of Lyme disease if they work at sites with infected ticks. This includes construction, landscaping, forestry, brush clearing, land surveying, farming, railroad work, oil field work, utility line work, park or wildlife management.<a href="#cite_note-153">[153]</a><a href="#cite_note-154">[154]</a> U.S. workers in the northeastern and north-central states are at highest risk of exposure to infected ticks. Ticks may also transmit other tick-borne diseases to workers in these and other regions of the country. Worksites with woods, bushes, high grass or <a href="/wiki/Leaf_litter" class="mw-redirect" title="Leaf litter">leaf litter</a> are likely to have more ticks. Outdoor workers should be most careful to protect themselves in the late spring and summer when young ticks are most active.<a href="#cite_note-cdclyme-155">[155]</a> <div class="mw-heading mw-heading3"><h3 id="Host_animals">Host animals</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=20" title="Edit section: Host animals">edit</a>]</div> Ticks can feed upon the blood of a wide array of possible host species, including <a href="/wiki/Lizards" class="mw-redirect" title="Lizards">lizards</a>, <a href="/wiki/Birds" class="mw-redirect" title="Birds">birds</a>, <a href="/wiki/Mice" class="mw-redirect" title="Mice">mice</a>, <a href="/wiki/Cats" class="mw-redirect" title="Cats">cats</a>, <a href="/wiki/Dogs" class="mw-redirect" title="Dogs">dogs</a>, <a href="/wiki/Deer" title="Deer">deer</a>, <a href="/wiki/Cattle" title="Cattle">cattle</a> and <a href="/wiki/Humans" class="mw-redirect" title="Humans">humans</a>. The extent to which a tick can feed, reproduce, and spread will depend on the type and availability of its hosts. Whether it will spread disease is also affected by its available hosts. Some species, such as lizards, are referred to as "dilution hosts" because they don't tend to support Lyme disease pathogens and so decrease the likelihood that the disease will be passed on by ticks feeding on them. <a href="/wiki/White-tailed_deer" title="White-tailed deer">White-tailed deer</a> are both a food source and a "reproductive host", where ticks tend to mate.<a href="#cite_note-156">[156]</a> The <a href="/wiki/White-footed_mouse" title="White-footed mouse">white-footed mouse</a> is a <a href="/wiki/Reservoir_host" class="mw-redirect" title="Reservoir host">reservoir host</a> in which the pathogen for Lyme disease can survive. Availability of hosts can have significant impacts on the transmission of Lyme disease. A greater diversity of hosts, or of those that don't support the pathogen, tends to decrease the likelihood that the disease will be transmitted.<a href="#cite_note-Chrobak-157">[157]</a> In the United States, one approach to reducing the incidence of Lyme and other deer tick-borne diseases has been to greatly reduce the deer population on which the adult ticks depend for feeding and reproduction. Lyme disease cases fell following deer eradication on an island, <a href="/wiki/Monhegan,_Maine" title="Monhegan, Maine">Monhegan, Maine</a>,<a href="#cite_note-Rand-158">[158]</a> and following deer control in Mumford Cove, Connecticut.<a href="#cite_note-managing_deer_2007-159">[159]</a> Advocates have suggested reducing the deer population to levels of 8 to 10 deer per square mile, compared to levels of 60 or more deer per square mile in the areas of the country with the highest Lyme disease rates.<a href="#cite_note-kirby_2004-160">[160]</a> While these studies have found these effects, other studies have found opposite effects. A study done in Massachusetts removed deer and did not see a significant decrease in tick abundance afterwards.<a href="#cite_note-161">[161]</a> Another study done in New Jersey removed deer and also did not see a reduction in the number of questing ticks and determined that deer culling is an unlikely way to effectively control tick populations<a href="#cite_note-162">[162]</a>. One study summarized the results of multiple studies all looking at deer reduction controlling tick populations and determined that deer control cant be used as a standalone reduction for Lyme disease. It also claims that since most of the studies looking at this are not good representatives of areas with high human Lyme disease risk. <a href="#cite_note-163">[163]</a> There is varying information on whether or not the removal of deer is actually a way to control the Lyme disease epidemic. Removal of smaller mammals that are fed on by juveniles who are more actively acquiring and spreading the pathogen, would decrease Lyme disease risk the most.<a href="#cite_note-164">[164]</a> Others have noted that while deer are reproductive hosts, they are not Borrelia burgdorferi reservoirs. This is because it was found that white-tailed deer blood actually kills the Borrelia burgdorferi bacteria.<a href="#cite_note-165">[165]</a> Researchers have suggested that smaller, less obviously visible Lyme reservoirs, like <a href="/wiki/White-footed_mice" class="mw-redirect" title="White-footed mice">white-footed mice</a> and <a href="/wiki/Eastern_chipmunks" class="mw-redirect" title="Eastern chipmunks">Eastern chipmunks</a>, may more strongly impact Lyme disease occurrence. Ecosystem studies in New York state suggest that white-footed mice thrive when forests are broken into smaller isolated chunks of woodland with fewer rodent predators. With more rodents harboring the disease, the odds increase that a tick will feed on a disease-harboring rodent and that someone will pick up a disease-carrying tick in their garden or walking in the woods. Data indicates that the smaller the wooded area, the more ticks it will contain and the likely they are to carry Lyme disease, supporting the idea that <a href="/wiki/Deforestation" title="Deforestation">deforestation</a> and habitat fragmentation affect ticks, hosts and disease transmission.<a href="#cite_note-Chrobak-157">[157]</a> Tick-borne diseases are estimated to affect ~80 % of <a href="/wiki/Cattle" title="Cattle">cattle</a> worldwide.<a href="#cite_note-Rochlin-166">[166]</a> They also affect cats, dogs, and other pets. Routine veterinary control of <a href="/wiki/Ticks_of_domestic_animals" title="Ticks of domestic animals">ticks of domestic animals</a> through the use of <a href="/wiki/Acaricide" title="Acaricide">acaricides</a> has been suggested as a way to reduce exposure of humans to ticks. However, chemical control with acaricides is now criticized on a number of grounds. Ticks appear to develop resistance to acaricides; acaricides are costly; and there are concerns over their toxicity and the potential for chemical residues to affect food and the environment.<a href="#cite_note-Rajput-167">[167]</a> In Europe, known reservoirs of Borrelia burgdorferi were 9 small mammals, 7 medium-sized mammals and 16 species of birds (including passerines, sea-birds and pheasants).<a href="#cite_note-gern1998-168">[168]</a> These animals seem to transmit spirochetes to ticks and thus participate in the natural circulation of B. burgdorferi in Europe. The <a href="/wiki/Mus_musculus" class="mw-redirect" title="Mus musculus">house mouse</a> is also suspected as well as other species of small rodents, particularly in Eastern Europe and Russia.<a href="#cite_note-gern1998-168">[168]</a> "The reservoir species that contain the most pathogens are the European roe deer <a href="/wiki/Capreolus_capreolus" class="mw-redirect" title="Capreolus capreolus">Capreolus capreolus</a>;<a href="#cite_note-Wodecka2013-169">[169]</a> "it does not appear to serve as a major reservoir of B. burgdorferi" thought Jaenson & al. (1992)<a href="#cite_note-170">[170]</a> (incompetent host for B. burgdorferi and TBE virus) but it is important for feeding the ticks,<a href="#cite_note-171">[171]</a> as <a href="/wiki/Red_deer" title="Red deer">red deer</a> and wild <a href="/wiki/Boars" class="mw-redirect" title="Boars">boars</a> (<a href="/wiki/Sus_scrofa" class="mw-redirect" title="Sus scrofa">Sus scrofa</a>),<a href="#cite_note-Wodecka2013-169">[169]</a> in which one Rickettsia and three Borrelia species were identified",<a href="#cite_note-Wodecka2013-169">[169]</a> with high risks of coinfection in roe deer.<a href="#cite_note-172">[172]</a> Nevertheless, in the 2000s, in roe deer in Europe "two species of Rickettsia and two species of Borrelia were identified".<a href="#cite_note-Wodecka2013-169">[169]</a> <div class="mw-heading mw-heading2"><h2 id="Vaccination">Vaccination</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=21" title="Edit section: Vaccination">edit</a>]</div> As of 2023<a class="external text" href="https://en.wikipedia.org/w/index.php?title=Lyme_disease&action=edit">[update]</a> no human vaccines for Lyme disease were available.<a href="#cite_note-cdc-vaccine-27">[27]</a> The only human vaccine to advance to market was LYMErix, which was available from 1998, but discontinued in 2002.<a href="#cite_note-O'Bier2021-173">[173]</a> The vaccine candidate VLA15 was scheduled to start a phase 3 trial in the third quarter of 2022, with other research ongoing. Multiple vaccines are available for the prevention of Lyme disease in dogs. <div class="mw-heading mw-heading3"><h3 id="LYMErix">LYMErix</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=22" title="Edit section: LYMErix">edit</a>]</div> The vaccine LYMErix was available from 1998 to 2002. The <a href="/wiki/Recombinant_DNA#Applications_of_recombinant_DNA_technology" title="Recombinant DNA">recombinant vaccine</a> against Lyme disease, based on the outer surface protein A (OspA) of B. burgdorferi with aluminum hydroxide as adjuvant, was developed by <a href="/wiki/GlaxoSmithKline#SmithKline_Beecham" class="mw-redirect" title="GlaxoSmithKline">SmithKline Beecham</a>. In <a href="/wiki/Clinical_trial" title="Clinical trial">clinical trials</a> involving more than 10,000 people, the vaccine was found to confer protective immunity to Lyme disease in 76% of adults after three doses with only mild or moderate and transient <a href="/wiki/Adverse_effect" title="Adverse effect">adverse effects</a>.<a href="#cite_note-Poland_2001-174">[174]</a><a href="#cite_note-Poland2011-175">[175]</a> On 21 December 1998, the <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) approved LYMErix on the basis of these trials for persons of ages 15 through 70.<a href="#cite_note-Poland2011-175">[175]</a><a href="#cite_note-O'Bier2021-173">[173]</a> Following approval of the <a href="/wiki/Vaccine" title="Vaccine">vaccine</a>, its entry into clinical practice was slow for a variety of reasons, including its cost, which was often not reimbursed by insurance companies.<a href="#cite_note-rowe_199-176">[176]</a> Subsequently, hundreds of vaccine recipients reported they had developed <a href="/wiki/Autoimmunity" title="Autoimmunity">autoimmune</a> and other side effects. Supported by some advocacy groups, a number of <a href="/wiki/Class-action_lawsuit" class="mw-redirect" title="Class-action lawsuit">class-action lawsuits</a> were filed against <a href="/wiki/GlaxoSmithKline" class="mw-redirect" title="GlaxoSmithKline">GlaxoSmithKline</a>, alleging the vaccine had caused these health problems. These claims were investigated by the FDA and the Centers for Disease Control, which found no connection between the vaccine and the autoimmune complaints.<a href="#cite_note-uphill-177">[177]</a> Despite the lack of evidence that the complaints were caused by the vaccine, sales plummeted and LYMErix was withdrawn from the U.S. market by GlaxoSmithKline in February 2002,<a href="#cite_note-vaccine_2008-178">[178]</a> in the setting of negative media coverage and fears of vaccine side effects.<a href="#cite_note-uphill-177">[177]</a><a href="#cite_note-cautionary-179">[179]</a> The fate of LYMErix was described in the medical literature as a "cautionary tale";<a href="#cite_note-cautionary-179">[179]</a> an editorial in <a href="/wiki/Nature_(journal)" title="Nature (journal)">Nature</a> cited the withdrawal of LYMErix as an instance in which "unfounded public fears place pressures on vaccine developers that go beyond reasonable safety considerations."<a href="#cite_note-safe-180">[180]</a> The original developer of the OspA vaccine at the <a href="/wiki/Max_Planck_Institute" class="mw-redirect" title="Max Planck Institute">Max Planck Institute</a> told Nature: "This just shows how irrational the world can be ... There was no scientific justification for the first OspA vaccine LYMErix being pulled."<a href="#cite_note-uphill-177">[177]</a><a href="#cite_note-181">[181]</a> <div class="mw-heading mw-heading3"><h3 id="VLA15">VLA15</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=23" title="Edit section: VLA15">edit</a>]</div> The hexavalent (OspA) protein subunit-based vaccine candidate VLA15 was developed by <a href="/wiki/Valneva" class="mw-redirect" title="Valneva">Valneva</a>. It was granted <a href="/wiki/Fast_track_(FDA)" title="Fast track (FDA)">fast track designation</a> by the U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> in July 2017.<a href="#cite_note-182">[182]</a><a href="#cite_note-183">[183]</a> In April 2020 <a href="/wiki/Pfizer" title="Pfizer">Pfizer</a> paid $130 million for the rights to the vaccine, and the companies are developing it together, performing multiple phase 2 trials.<a href="#cite_note-fiercebt-022022-184">[184]</a> A phase 3 trial of VLA15 was scheduled for late 2022, recruiting volunteers at test sites located across the northeastern United States and in Europe.<a href="#cite_note-185">[185]</a><a href="#cite_note-ClinicalTrial-186">[186]</a> Participants were scheduled to receive an initial three-dose series of vaccines over the course of five to nine months, followed by a booster dose after twelve months, with both the initial series and the booster dose scheduled to be complete before the year's peak Lyme disease season.<a href="#cite_note-ClinicalTrial-186">[186]</a> <div class="mw-heading mw-heading3"><h3 id="Other_research">Other research</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=24" title="Edit section: Other research">edit</a>]</div> An <a href="/wiki/MRNA_vaccine" title="MRNA vaccine">mRNA vaccine</a> designed to cause a strong fast immune response to tick saliva allowed the immune system to detect and remove the ticks from test animals before they were able to transmit the infectious bacteria.<a href="#cite_note-187">[187]</a> The vaccine contains mRNAs for the body to build 19 proteins in tick saliva which, by enabling quick development of <a href="/wiki/Erythema" title="Erythema">erythema</a> (itchy redness) at the bite site, protects guinea pigs against Lyme disease. It also protected the test animals if the tick is not removed if only one tick, but not three, remain attached.<a href="#cite_note-188">[188]</a><a href="#cite_note-189">[189]</a> <div class="mw-heading mw-heading3"><h3 id="Canine_vaccines">Canine vaccines</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=25" title="Edit section: Canine vaccines">edit</a>]</div> <a href="/wiki/Vaccination_of_dogs" title="Vaccination of dogs">Canine vaccines</a> have been formulated and approved for the prevention of Lyme disease in dogs. Currently, three Lyme disease vaccines are available. LymeVax, formulated by Fort Dodge Laboratories, contains intact dead spirochetes which expose the host to the organism. Galaxy Lyme, Intervet-<a href="/wiki/Schering-Plough" title="Schering-Plough">Schering-Plough</a>'s vaccine, targets <a href="/wiki/Virulence-related_outer_membrane_protein_family" title="Virulence-related outer membrane protein family">proteins OspC and OspA</a>. The OspC antibodies kill any of the bacteria that have not been killed by the OspA antibodies. Canine Recombinant Lyme, formulated by <a href="/wiki/Merial" class="mw-redirect" title="Merial">Merial</a>, generates antibodies against the OspA protein so a tick feeding on a vaccinated dog draws in blood full of anti-OspA antibodies, which kill the spirochetes in the tick's gut before they are transmitted to the dog.<a href="#cite_note-Brooks,_DVM-190">[190]</a> <div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=26" title="Edit section: Treatment">edit</a>]</div> <a href="/wiki/Antibiotics" class="mw-redirect" title="Antibiotics">Antibiotics</a> are the primary treatment.<a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-wright_2012-28">[28]</a> The specific approach to their use is dependent on the individual affected and the stage of the disease.<a href="#cite_note-wright_2012-28">[28]</a> For most people with early localized infection, oral administration of <a href="/wiki/Doxycycline" title="Doxycycline">doxycycline</a> is widely recommended as the first choice, as it is effective against not only Borrelia bacteria but also a variety of other illnesses carried by ticks.<a href="#cite_note-wright_2012-28">[28]</a> People taking doxycycline should avoid sun exposure because of <a href="/wiki/Photosensitivity" title="Photosensitivity">higher risk of sunburns</a>.<a href="#cite_note-idsa_guideline-35">[35]</a> Doxycycline is contraindicated in children younger than eight years of age and women who are pregnant or breastfeeding;<a href="#cite_note-wright_2012-28">[28]</a> alternatives to doxycycline are <a href="/wiki/Amoxicillin" title="Amoxicillin">amoxicillin</a>, <a href="/wiki/Cefuroxime_axetil" title="Cefuroxime axetil">cefuroxime axetil</a>, and <a href="/wiki/Azithromycin" title="Azithromycin">azithromycin</a>.<a href="#cite_note-wright_2012-28">[28]</a> Azithromycin is recommended only in case of intolerance to the other antibiotics.<a href="#cite_note-idsa_guideline-35">[35]</a> The standard treatment for <a href="/wiki/Cellulitis" title="Cellulitis">cellulitis</a>, <a href="/wiki/Cephalexin" class="mw-redirect" title="Cephalexin">cephalexin</a>, is not useful for Lyme disease.<a href="#cite_note-idsa_guideline-35">[35]</a> When it is unclear if a rash is caused by Lyme or cellulitis, the <a href="/wiki/Infectious_Diseases_Society_of_America" title="Infectious Diseases Society of America">IDSA</a> recommends treatment with <a href="/wiki/Cefuroxime" title="Cefuroxime">cefuroxime</a> or <a href="/wiki/Amoxicillin/clavulanic_acid" title="Amoxicillin/clavulanic acid">amoxicillin/clavulanic acid</a>, as these are effective against both infections.<a href="#cite_note-idsa_guideline-35">[35]</a> Individuals with early disseminated or late Lyme infection may have symptomatic cardiac disease, Lyme arthritis, or neurologic symptoms like <a href="/wiki/Facial_palsy" class="mw-redirect" title="Facial palsy">facial palsy</a>, <a href="/wiki/Radiculopathy" title="Radiculopathy">radiculopathy</a>, <a href="/wiki/Meningitis" title="Meningitis">meningitis</a>, or <a href="/wiki/Peripheral_neuropathy" title="Peripheral neuropathy">peripheral neuropathy</a>.<a href="#cite_note-wright_2012-28">[28]</a> Intravenous administration of <a href="/wiki/Ceftriaxone" title="Ceftriaxone">ceftriaxone</a> is recommended as the first choice in these cases;<a href="#cite_note-wright_2012-28">[28]</a> <a href="/wiki/Cefotaxime" title="Cefotaxime">cefotaxime</a> and doxycycline are available as alternatives.<a href="#cite_note-wright_2012-28">[28]</a> Treatment regimens for Lyme disease range from 7-14 days in early localized disease, to 14–21 days in early disseminated disease to 14–28 days in late disseminated disease.<a href="#cite_note-guidelines-2020-55">[55]</a> <a href="/wiki/Neuroborreliosis" title="Neuroborreliosis">Neurologic complications of Lyme disease</a> may be treated with <a href="/wiki/Doxycycline" title="Doxycycline">doxycycline</a> as it can be taken by mouth and has a lower cost, although in North America evidence of efficacy is only indirect.<a href="#cite_note-pmid17522387-120">[120]</a> In case of failure, guidelines recommend retreatment with injectable <a href="/wiki/Ceftriaxone" title="Ceftriaxone">ceftriaxone</a>.<a href="#cite_note-pmid17522387-120">[120]</a> Several months after treatment for Lyme arthritis, if joint swelling persists or returns, a second round of antibiotics may be considered; intravenous antibiotics are preferred for retreatment in case of poor response to oral antibiotics.<a href="#cite_note-wright_2012-28">[28]</a><a href="#cite_note-idsa_guideline-35">[35]</a> Outside of that, a prolonged antibiotic regimen lasting more than 28 days is not recommended as no evidence shows it to be effective.<a href="#cite_note-wright_2012-28">[28]</a><a href="#cite_note-191">[191]</a> IgM and IgG antibody levels may be elevated for years even after successful treatment with antibiotics.<a href="#cite_note-wright_2012-28">[28]</a> As antibody levels are not indicative of treatment success, testing for them is not recommended.<a href="#cite_note-wright_2012-28">[28]</a> Facial palsy may resolve without treatment: however, antibiotic treatment is recommended to stop other Lyme complications.<a href="#cite_note-idsa_guideline-35">[35]</a> Corticosteroids are not recommended when facial palsy is caused by Lyme disease.<a href="#cite_note-garro_2018-44">[44]</a> In those with facial palsy, frequent use of artificial tears while awake is recommended, along with ointment and a patch or taping the eye closed when sleeping.<a href="#cite_note-garro_2018-44">[44]</a><a href="#cite_note-OTC-Drops-192">[192]</a> About a third of people with Lyme carditis need a temporary <a href="/wiki/Artificial_cardiac_pacemaker" title="Artificial cardiac pacemaker">pacemaker</a> until their heart conduction abnormality resolves, and 21% need to be hospitalized.<a href="#cite_note-fish_2008-46">[46]</a> Lyme carditis should not be treated with corticosteroids.<a href="#cite_note-fish_2008-46">[46]</a> People with Lyme arthritis should limit their level of physical activity to avoid damaging affected joints, and in case of limping should use crutches.<a href="#cite_note-arvikar_2015-193">[193]</a> Pain associated with Lyme disease may be treated with <a href="/wiki/Nonsteroidal_anti-inflammatory_drug" title="Nonsteroidal anti-inflammatory drug">nonsteroidal anti-inflammatory drugs</a> (NSAIDs).<a href="#cite_note-idsa_guideline-35">[35]</a> Corticosteroid <a href="/wiki/Joint_injection" title="Joint injection">joint injections</a> are not recommended for Lyme arthritis that is being treated with antibiotics.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-arvikar_2015-193">[193]</a> People with Lyme arthritis treated with intravenous antibiotics or two months of oral antibiotics who continue to have <a href="/wiki/Synovitis" title="Synovitis">joint swelling</a> two months after treatment and have negative <a href="/wiki/Polymerase_chain_reaction" title="Polymerase chain reaction">PCR</a> test for <a href="/wiki/Borrelia" title="Borrelia">Borrelia</a> <a href="/wiki/DNA" title="DNA">DNA</a> in the <a href="/wiki/Synovial_fluid" title="Synovial fluid">synovial fluid</a> are said to have post-antibiotic Lyme arthritis; this is more common after infection by certain Borrelia strains in people with certain genetic and immunologic characteristics.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-guidelines-2020-55">[55]</a><a href="#cite_note-arvikar_2015-193">[193]</a> Post-antibiotic Lyme arthritis may be symptomatically treated with NSAIDs, <a href="/wiki/Disease-modifying_antirheumatic_drugs" class="mw-redirect" title="Disease-modifying antirheumatic drugs">disease-modifying antirheumatic drugs</a> (DMARDs), arthroscopic <a href="/wiki/Synovectomy" title="Synovectomy">synovectomy</a>, or physical therapy.<a href="#cite_note-guidelines-2020-55">[55]</a><a href="#cite_note-arvikar_2015-193">[193]</a> People receiving treatment should be advised that reinfection is possible and <a href="#Prevention">how to prevent it</a>.<a href="#cite_note-lyme_guidelines_uk-115">[115]</a> <div class="mw-heading mw-heading2"><h2 id="Prognosis">Prognosis</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=27" title="Edit section: Prognosis">edit</a>]</div> Lyme disease's typical first sign, the <a href="/wiki/Erythema_migrans" title="Erythema migrans">erythema migrans</a> (EM) rash, resolves within several weeks even without treatment.<a href="#cite_note-NEJM2014-4">[4]</a> However, in untreated people, the infection often disseminates to the nervous system, heart or joints, possibly causing permanent damage to body tissues.<a href="#cite_note-idsa_guideline-35">[35]</a> People who receive recommended antibiotic treatment within several days of appearance of an initial EM rash have the best prospects.<a href="#cite_note-aucott_2008-113">[113]</a> Recovery may not be total or immediate. The percentage of people achieving full recovery in the United States increases from about 64–71% at end of treatment for EM rash to about 84–90% after 30 months; higher percentages are reported in Europe.<a href="#cite_note-wormser_2003-194">[194]</a><a href="#cite_note-stupica_2012-195">[195]</a> Treatment failure, i.e. persistence of original or appearance of new signs of the disease, occurs only in a few people.<a href="#cite_note-wormser_2003-194">[194]</a> Remaining people are considered cured but continue to experience subjective symptoms, e.g. <a href="/wiki/Arthralgia" title="Arthralgia">joint</a> or <a href="/wiki/Myalgia" title="Myalgia">muscle pains</a> or <a href="/wiki/Fatigue" title="Fatigue">fatigue</a>.<a href="#cite_note-dattwyler_1997-196">[196]</a> These symptoms are usually mild and nondisabling.<a href="#cite_note-dattwyler_1997-196">[196]</a> People treated only after nervous system manifestations of the disease may end up with objective neurological deficits, in addition to subjective symptoms.<a href="#cite_note-idsa_guideline-35">[35]</a> In Europe, an average of 32–33 months after initial Lyme symptoms in people treated mostly with doxycycline 200 mg for 14–21 days, the percentage of people with lingering symptoms was much higher among those diagnosed with <a href="/wiki/Neuroborreliosis" title="Neuroborreliosis">neuroborreliosis</a> (50%) than among those with only an EM rash (16%).<a href="#cite_note-vrethem_2002-197">[197]</a> In another European study, 5 years after treatment for neuroborreliosis lingering symptoms were less common among children (15%) than adults (30%), and in the latter were less common among those treated within 30 days of the first symptom (16%) than among those treated later (39%); among those with lingering symptoms, 54% had daily activities restricted and 19% were on sick leave or incapacitated.<a href="#cite_note-berglund_2002-198">[198]</a> Some data suggest that about 90% of Lyme <a href="/wiki/Facial_palsy" class="mw-redirect" title="Facial palsy">facial palsies</a> treated with antibiotics recover fully a median of 24 days after appearing and most of the rest recover with only mild abnormality.<a href="#cite_note-clark_1985-199">[199]</a><a href="#cite_note-dovetall_1999-200">[200]</a> However, in Europe 41% of people treated for facial palsy had other lingering symptoms at followup up to 6 months later, including 28% with <a href="/wiki/Hypoesthesia" title="Hypoesthesia">numbness</a> or <a href="/wiki/Paresthesia" title="Paresthesia">altered sensation</a> and 14% with <a href="/wiki/Fatigue" title="Fatigue">fatigue</a> or <a href="/wiki/Attentional_control" title="Attentional control">concentration</a> problems.<a href="#cite_note-dovetall_1999-200">[200]</a> Palsies in both sides of the face are associated with worse and longer time to recovery.<a href="#cite_note-clark_1985-199">[199]</a><a href="#cite_note-dovetall_1999-200">[200]</a> Historical data suggests that untreated people with facial palsies recover at nearly the same rate, but 88% subsequently have Lyme arthritis.<a href="#cite_note-clark_1985-199">[199]</a><a href="#cite_note-kalish_2001-201">[201]</a> Other research shows that <a href="/wiki/Synkinesis" title="Synkinesis">synkinesis</a> (involuntary movement of a facial muscle when another one is voluntarily moved) can become evident only 6–12 months after facial palsy appears to be resolved, as damaged nerves regrow and sometimes connect to incorrect muscles.<a href="#cite_note-jowett_2017-202">[202]</a> Synkinesis is associated with <a href="/wiki/Corticosteroid" title="Corticosteroid">corticosteroid</a> use.<a href="#cite_note-jowett_2017-202">[202]</a> In longer-term follow-up, 16–23% of Lyme facial palsies do not fully recover.<a href="#cite_note-jowett_2017-202">[202]</a> In Europe, about a quarter of people with <a href="/wiki/Bannwarth_syndrome" class="mw-redirect" title="Bannwarth syndrome">Bannwarth syndrome</a> (Lyme <a href="/wiki/Radiculopathy" title="Radiculopathy">radiculopathy</a> and <a href="/wiki/Aseptic_meningitis" title="Aseptic meningitis">lymphocytic meningitis</a>) treated with <a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous">intravenous</a> <a href="/wiki/Ceftriaxone" title="Ceftriaxone">ceftriaxone</a> for 14 days an average of 30 days after first symptoms had to be retreated 3–6 months later because of unsatisfactory clinical response or continued <a href="/wiki/Lymphocytic_pleocytosis" title="Lymphocytic pleocytosis">objective markers of infection</a> in <a href="/wiki/Cerebrospinal_fluid" title="Cerebrospinal fluid">cerebrospinal fluid</a>; after 12 months, 64% recovered fully, 31% had nondisabling mild or infrequent symptoms that did not require regular use of analgesics, and 5% had symptoms that were disabling or required substantial use of analgesics.<a href="#cite_note-ogrinc_bannwarth-43">[43]</a> The most common lingering nondisabling symptoms were headache, <a href="/wiki/Fatigue" title="Fatigue">fatigue</a>, <a href="/wiki/Paresthesia" title="Paresthesia">altered sensation</a>, <a href="/wiki/Arthralgia" title="Arthralgia">joint pains</a>, <a href="/wiki/Memory" title="Memory">memory</a> disturbances, <a href="/wiki/Malaise" title="Malaise">malaise</a>, <a href="/wiki/Radiculitis" class="mw-redirect" title="Radiculitis">radicular pain</a>, <a href="/wiki/Sleep" title="Sleep">sleep</a> disturbances, <a href="/wiki/Myalgia" title="Myalgia">muscle pains</a>, and <a href="/wiki/Attentional_control" title="Attentional control">concentration</a> disturbances. Lingering disabling symptoms included <a href="/wiki/Facial_palsy" class="mw-redirect" title="Facial palsy">facial palsy</a> and other <a href="/wiki/Paresis" title="Paresis">impaired movement</a>.<a href="#cite_note-ogrinc_bannwarth-43">[43]</a> Recovery from late neuroborreliosis tends to take longer and be less complete than from early neuroborreliosis, probably because of irreversible neurologic damage.<a href="#cite_note-idsa_guideline-35">[35]</a> About half the people with Lyme carditis progress to complete <a href="/wiki/Heart_block" title="Heart block">heart block</a>, but it usually resolves in a week.<a href="#cite_note-fish_2008-46">[46]</a> Other Lyme heart conduction abnormalities resolve typically within 6 weeks.<a href="#cite_note-fish_2008-46">[46]</a> About 94% of people have full recovery, but 5% need a permanent <a href="/wiki/Artificial_cardiac_pacemaker" title="Artificial cardiac pacemaker">pacemaker</a> and 1% end up with persistent heart block (the actual percentage may be higher because of unrecognized cases).<a href="#cite_note-fish_2008-46">[46]</a> Lyme <a href="/wiki/Cardiac_muscle" title="Cardiac muscle">myocardial</a> complications usually are mild and self-limiting.<a href="#cite_note-fish_2008-46">[46]</a> However, in some cases Lyme carditis can be fatal.<a href="#cite_note-fish_2008-46">[46]</a> Recommended antibiotic treatments are effective in about 90% of Lyme arthritis cases, although it can take several months for inflammation to resolve and a second round of antibiotics is often necessary.<a href="#cite_note-idsa_guideline-35">[35]</a> Antibiotic-refractory Lyme arthritis also eventually resolves, typically within 9–14 months (range 4 months – 4 years); <a href="/wiki/DMARD" class="mw-redirect" title="DMARD">DMARDs</a> or <a href="/wiki/Synovectomy" title="Synovectomy">synovectomy</a> can accelerate recovery.<a href="#cite_note-arvikar_2015-193">[193]</a> Reinfection is not uncommon. In a U.S. study, 6–11% of people treated for an EM rash had another EM rash within 30 months.<a href="#cite_note-wormser_2003-194">[194]</a> The second rash typically is due to infection by a different <a href="/wiki/Borrelia" title="Borrelia">Borrelia</a> strain.<a href="#cite_note-nadelman_2012-203">[203]</a> <div class="mw-heading mw-heading3"><h3 id="Post-treatment_Lyme_disease_syndrome">Post-treatment Lyme disease syndrome</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=28" title="Edit section: Post-treatment Lyme disease syndrome">edit</a>]</div> Chronic symptoms like pain, fatigue, or cognitive impairment are experienced by 5–20% of people who contract Lyme disease, even after completing treatment. This is called Post-treatment Lyme disease syndrome, or PTLDS.<a href="#cite_note-:0-24">[24]</a><a href="#cite_note-:1-204">[204]</a> The cause is unknown. One hypothesis is that a persistent, difficult-to-detect infection remains. Work with mice, dogs, and non-human primates have shown evidence of persistent B. burgdorferi, although these remaining bacteria are hard to cultivate and <a href="/wiki/Koch%27s_postulates" title="Koch's postulates">Koch's postulates</a> are hard to prove. Another hypothesis is that autoimmunity has been triggered by the infection. Auto–immune responses are known to occur following other infections, including Campylobacter (<a href="/wiki/Guillain-Barr%C3%A9_syndrome" class="mw-redirect" title="Guillain-Barré syndrome">Guillain-Barré syndrome</a>), Chlamydia (reactive arthritis), and strep throat (rheumatic heart disease). A third hypothesis is that symptoms are simply unrelated to the previous Lyme infection.<a href="#cite_note-CDC_2016-205">[205]</a><a href="#cite_note-Post-treatment_Lyme,_Rebman-206">[206]</a> There is no proven treatment for Post-treatment Lyme disease syndrome. While short-term antibiotics are effective in early Lyme disease, prolonged antibiotics are not. They have been shown ineffective in placebo-controlled trials and carry the risk of serious, sometimes deadly complications. Generally, treatment is symptomatic and is similar to the management of <a href="/wiki/Fibromyalgia" title="Fibromyalgia">fibromyalgia</a> or <a href="/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome" title="Myalgic encephalomyelitis/chronic fatigue syndrome">ME/CFS</a>. PTLDS usually gets better over time, but recovery may take many months.<a href="#cite_note-CDC_2016-205">[205]</a> <div class="mw-heading mw-heading2"><h2 id="Epidemiology">Epidemiology</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=29" title="Edit section: Epidemiology">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Geographical_distribution_of_reported_Lyme_Disease_cases.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/Geographical_distribution_of_reported_Lyme_Disease_cases.png/300px-Geographical_distribution_of_reported_Lyme_Disease_cases.png" decoding="async" width="300" height="139" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/Geographical_distribution_of_reported_Lyme_Disease_cases.png/450px-Geographical_distribution_of_reported_Lyme_Disease_cases.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7f/Geographical_distribution_of_reported_Lyme_Disease_cases.png/600px-Geographical_distribution_of_reported_Lyme_Disease_cases.png 2x" data-file-width="1357" data-file-height="628" /></a><figcaption>Countries with reported Lyme disease cases</figcaption></figure> Lyme disease <a href="/wiki/Endemic_(epidemiology)" title="Endemic (epidemiology)">occurs regularly</a> in <a href="/wiki/Northern_Hemisphere" title="Northern Hemisphere">Northern Hemisphere</a> temperate regions.<a href="#cite_note-Higgins_2004-207">[207]</a> An estimated 476,000 people a year are diagnosed and treated for the disease in the United States. This number is probably an overestimate due to overdiagnosis and overtreatment.<a href="#cite_note-cdc-how-many-6">[6]</a><a href="#cite_note-cdc-estimate-2021-7">[7]</a> Over 200,000 people a year are diagnosed and treated in Europe.<a href="#cite_note-comparison-2021-8">[8]</a><a href="#cite_note-NEJM2014-4">[4]</a><a href="#cite_note-Berg2014-208">[208]</a> There is a suggestion that tick populations and Lyme disease occurrence are increasing and spreading into new areas, owing in part to the warming temperatures of <a href="/wiki/Climate_change" title="Climate change">climate change</a>. However, tick-borne disease systems are complex, and determining whether changes are due to climate change or other drivers can be difficult.<a href="#cite_note-Chrobak-157">[157]</a><a href="#cite_note-Gilbert-209">[209]</a> Lyme disease effects are comparable among males and females. A wide range of age groups is affected, though the number of cases is highest among 10- to 19-year-olds. <div class="mw-heading mw-heading3"><h3 id="Africa">Africa</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=30" title="Edit section: Africa">edit</a>]</div> In northern Africa, B. burgdorferi sensu lato has been identified in <a href="/wiki/Morocco" title="Morocco">Morocco</a>, <a href="/wiki/Algeria" title="Algeria">Algeria</a>, <a href="/wiki/Egypt" title="Egypt">Egypt</a> and <a href="/wiki/Tunisia" title="Tunisia">Tunisia</a>.<a href="#cite_note-Bouattour_2004-210">[210]</a><a href="#cite_note-Dsouli_2006-211">[211]</a><a href="#cite_note-Helmy_2000-212">[212]</a> Lyme disease in sub-Saharan Africa is presently unknown, but evidence indicates it may occur in humans in this region. The abundance of hosts and tick vectors would favor the establishment of Lyme infection in Africa.<a href="#cite_note-Fivaz_1989-213">[213]</a> In East Africa, two cases of Lyme disease have been reported in <a href="/wiki/Kenya" title="Kenya">Kenya</a>.<a href="#cite_note-Jowi_2005-214">[214]</a> According The Federation of Infectious Diseases Societies of Southern Africa, Lyme disease is not known to be endemic in either South Africa or Mozambique.<a href="#cite_note-215">[215]</a> <div class="mw-heading mw-heading3"><h3 id="Asia">Asia</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=31" title="Edit section: Asia">edit</a>]</div> B. burgdorferi sensu lato-infested ticks are being found more frequently in Japan, as well as in northwest China, <a href="/wiki/Nepal" title="Nepal">Nepal</a>, <a href="/wiki/Thailand" title="Thailand">Thailand</a> and far eastern Russia.<a href="#cite_note-Li_1998-216">[216]</a><a href="#cite_note-pmid15623946-217">[217]</a> Borrelia has also been isolated in <a href="/wiki/Mongolia" title="Mongolia">Mongolia</a>.<a href="#cite_note-Walder_2006-218">[218]</a> <div class="mw-heading mw-heading3"><h3 id="Australia">Australia</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=32" title="Edit section: Australia">edit</a>]</div> Lyme disease is not considered endemic to Australia.<a href="#cite_note-pmid30746341-219">[219]</a> While there have been reports of people acquiring Lyme disease in Australia, and even evidence of closely related Borrelia species in ticks,<a href="#cite_note-pmid35502617-220">[220]</a> the evidence linking these cases to local transmission is limited. Ongoing research on resolving potential Borrelia species to Debilitating Symptom Complexes Attributed to Ticks (DSCATT) in Australia are ongoing.<a href="#cite_note-pmid36365042-221">[221]</a> <div class="mw-heading mw-heading3"><h3 id="Europe">Europe</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=33" title="Edit section: Europe">edit</a>]</div> In Europe, Lyme disease is caused by infection with one or more pathogenic European genospecies of the spirochaete B. burgdorferi sensu lato, mainly transmitted by the tick <a href="/wiki/Ixodes_ricinus" title="Ixodes ricinus">Ixodes ricinus</a>.<a href="#cite_note-pmid21794218-222">[222]</a> Cases of B. burgdorferi sensu lato-infected ticks are found predominantly in central Europe, particularly in <a href="/wiki/Slovenia" title="Slovenia">Slovenia</a> and Austria, but have been isolated in almost every country on the continent.<a href="#cite_note-pmid16819127-223">[223]</a> The number of cases in southern Europe, such as Italy and Portugal, is much lower.<a href="#cite_note-pmid17130658-224">[224]</a> Diagnosed cases in some Western countries, such as Iceland, are rising.<a href="#cite_note-225">[225]</a> Lyme disease is rare in Iceland. On average around 6 to 7 cases are diagnosed every year, primarily localised infections presenting as erythema migrans. None of the cases had a definitive Icelandic origin and the yearly number of cases has not been increasing.<a href="#cite_note-226">[226]</a> <div class="mw-heading mw-heading4"><h4 id="United_Kingdom">United Kingdom</h4>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=34" title="Edit section: United Kingdom">edit</a>]</div> In the United Kingdom the number of laboratory-confirmed cases of Lyme disease has been rising steadily since voluntary reporting was introduced in 1986<a href="#cite_note-hpaEpidemiology-227">[227]</a> when 68 cases were recorded in the UK and Ireland combined.<a href="#cite_note-Muhlemann_1987-228">[228]</a> In the UK there were 23 confirmed cases in 1988 and 19 in 1990,<a href="#cite_note-hansard1991-229">[229]</a> but 973 in 2009<a href="#cite_note-hpaEpidemiology-227">[227]</a> and 953 in 2010.<a href="#cite_note-hpa5-15-230">[230]</a> Provisional figures for the first 3 quarters of 2011 show a 26% increase on the same period in 2010.<a href="#cite_note-disease_action_2011-231">[231]</a> It is thought, however, that the actual number of cases is significantly higher than suggested by the above figures, with England's <a href="/wiki/Health_Protection_Agency" title="Health Protection Agency">Health Protection Agency</a> estimating that there are between 2,000 and 3,000 cases in England and Wales per year<a href="#cite_note-hpa5-15-230">[230]</a> (with an average of around 15% of the infections acquired overseas<a href="#cite_note-hpaEpidemiology-227">[227]</a>), while Dr Darrel Ho-Yen, Director of the Scottish Toxoplasma Reference Laboratory and National Lyme Disease Testing Service, believes that the number of confirmed cases should be multiplied by 10 "to take account of wrongly diagnosed cases, tests giving false results, sufferers who weren't tested, people who are infected but not showing symptoms, failures to notify and infected individuals who don't consult a doctor."<a href="#cite_note-cassidy_2011-232">[232]</a><a href="#cite_note-danger_2009-233">[233]</a> Despite Lyme disease (Borrelia burgdorferi infection) being a <a href="/wiki/Notifiable_disease" title="Notifiable disease">notifiable disease</a> in Scotland<a href="#cite_note-scotland_2012-234">[234]</a> since January 1990<a href="#cite_note-hansard_1997-235">[235]</a> which should therefore be reported on the basis of clinical suspicion, it is believed that many <a href="/wiki/General_practitioner" title="General practitioner">GPs</a> are unaware of the requirement.<a href="#cite_note-fox_2010-236">[236]</a> Mandatory reporting, limited to laboratory test results only, was introduced throughout the UK in October 2010, under the Health Protection (Notification) Regulations 2010.<a href="#cite_note-hpaEpidemiology-227">[227]</a> Although there is a greater number of cases of Lyme disease in the <a href="/wiki/New_Forest" title="New Forest">New Forest</a>, <a href="/wiki/Salisbury_Plain" title="Salisbury Plain">Salisbury Plain</a>, <a href="/wiki/Exmoor" title="Exmoor">Exmoor</a>, the <a href="/wiki/South_Downs" title="South Downs">South Downs</a>, parts of <a href="/wiki/Wiltshire" title="Wiltshire">Wiltshire</a> and <a href="/wiki/Berkshire" title="Berkshire">Berkshire</a>, <a href="/wiki/Thetford_Forest" title="Thetford Forest">Thetford Forest</a><a href="#cite_note-hpa_2013-237">[237]</a> and the West coast and islands of Scotland,<a href="#cite_note-defra_2009-238">[238]</a> infected ticks are widespread and can even be found in the parks of London.<a href="#cite_note-hansard1991-229">[229]</a><a href="#cite_note-tick_bite-239">[239]</a> A 1989 report found that 25% of forestry workers in the New Forest were <a href="/wiki/Seropositive" class="mw-redirect" title="Seropositive">seropositive</a>, as were between 2% and 4–5% of the general local population of the area.<a href="#cite_note-pmid8037992-240">[240]</a><a href="#cite_note-pmid2563850-241">[241]</a> Tests on pet dogs carried out throughout the country in 2009 indicated that around 2.5% of ticks in the UK may be infected, considerably higher than previously thought.<a href="#cite_note-Smith_2012-242">[242]</a><a href="#cite_note-bbc_dogs_2012-243">[243]</a> It is speculated that <a href="/wiki/Global_warming" class="mw-redirect" title="Global warming">global warming</a> may lead to an increase in tick activity in the future, as well as an increase in the amount of time that people spend in public parks, thus increasing the risk of infection.<a href="#cite_note-londong_2008-244">[244]</a> However no published research has proven this to be so. <div class="mw-heading mw-heading3"><h3 id="North_America">North America</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=35" title="Edit section: North America">edit</a>]</div> Many studies in North America have examined ecological and environmental correlates of the number of people affected by Lyme disease. A 2005 study using climate suitability modelling of I. scapularis projected that <a href="/wiki/Effects_of_climate_change_on_human_health" title="Effects of climate change on human health">climate change would cause</a> an overall 213% increase in suitable vector habitat by 2080, with northward expansions in Canada, increased suitability in the central U.S., and decreased suitable habitat and vector retraction in the southern U.S.<a href="#cite_note-Brownstein_etal_2005-245">[245]</a> A 2008 review of published studies concluded that the presence of forests or forested areas was the only variable that consistently elevated the risk of Lyme disease whereas other environmental variables showed little or no concordance between studies.<a href="#cite_note-Killilea_etal_2008-246">[246]</a> The authors argued that the factors influencing tick density and human risk between sites are still poorly understood, and that future studies should be conducted over longer time periods, become more standardized across regions, and incorporate existing knowledge of regional Lyme <a href="/wiki/Disease_ecology" title="Disease ecology">disease ecology</a>.<a href="#cite_note-Killilea_etal_2008-246">[246]</a> <div class="mw-heading mw-heading4"><h4 id="Canada">Canada</h4>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=36" title="Edit section: Canada">edit</a>]</div> The range of ticks able to carry Lyme disease has expanded from a limited area of Ontario to include areas of southern Quebec, Manitoba, northern Ontario, southern New Brunswick, southwest Nova Scotia and limited parts of Saskatchewan and Alberta, as well as British Columbia. Cases have been reported as far east as the island of Newfoundland.<a href="#cite_note-canada_lyme_map-112">[112]</a><a href="#cite_note-min_ag_2012-247">[247]</a><a href="#cite_note-fact_sheet_2012-248">[248]</a><a href="#cite_note-Ogden_2009-249">[249]</a> A model-based prediction by Leighton et al. (2012) suggests that the range of the I. scapularis tick will expand into Canada by 46 km/year over the next decade, with warming climatic temperatures as the main driver of increased speed of spread.<a href="#cite_note-Leighton_2012-250">[250]</a> <div class="mw-heading mw-heading4"><h4 id="Mexico">Mexico</h4>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=37" title="Edit section: Mexico">edit</a>]</div> A 2007 study suggests Borrelia burgdorferi infections are endemic to Mexico, from four cases reported between 1999 and 2000.<a href="#cite_note-cdc_dispatch_oct_2007-251">[251]</a> <div class="mw-heading mw-heading4"><h4 id="United_States">United States</h4>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=38" title="Edit section: United States">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Lyme_Disease_Risk_Map.gif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9d/Lyme_Disease_Risk_Map.gif/300px-Lyme_Disease_Risk_Map.gif" decoding="async" width="300" height="237" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9d/Lyme_Disease_Risk_Map.gif/450px-Lyme_Disease_Risk_Map.gif 1.5x, //upload.wikimedia.org/wikipedia/commons/9/9d/Lyme_Disease_Risk_Map.gif 2x" data-file-width="556" data-file-height="440" /></a><figcaption><a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">CDC</a> map showing the risk of Lyme disease in the United States, particularly its concentration in the <a href="/wiki/Northeast_Megalopolis" class="mw-redirect" title="Northeast Megalopolis">Northeast Megalopolis</a> and western <a href="/wiki/Wisconsin" title="Wisconsin">Wisconsin</a></figcaption></figure> Lyme disease is the most common tick-borne disease in North America and Europe, and one of the fastest-growing infectious diseases in the United States. Of cases reported to the United States CDC, the ratio of Lyme disease infection is 7.9 cases for every 100,000 persons. In the ten states where Lyme disease is most common, the average was 31.6 cases for every 100,000 persons for the year 2005.<a href="#cite_note-cdc_stats_2012-252">[252]</a><a href="#cite_note-mmwr_2007-253">[253]</a><a href="#cite_note-Bacon_2008-254">[254]</a> Although Lyme disease has been reported in all states due to travel-associated infections, about 99% of all reported cases are confined to just five geographic areas (New England, Mid-Atlantic, East-North Central, South Atlantic, and West North-Central).<a href="#cite_note-CDC-FAQ-90">[90]</a><a href="#cite_note-cdc_stats2-255">[255]</a><a href="#cite_note-nytimes.com-256">[256]</a> CDC implemented national surveillance of Lyme disease cases in 1991. Since then, reporting criteria has been modified multiple times.<a href="#cite_note-cdc-surveillance-257">[257]</a> The 2022 surveillance case definition classifies cases as confirmed, probable, and suspect.<a href="#cite_note-cdc-surveillance-2022-258">[258]</a> The number of reported cases of the disease has been increasing, as are endemic regions in North America. The CDC emphasizes that, while surveillance data has limitations, it is useful due to "uniformity, simplicity, and timeliness." While cases are under-reported in high-incidence areas, over-reporting is likely in low-incidence areas. Additionally, surveillance cases are reported by county of residence and not where an infection was necessarily contracted.<a href="#cite_note-cdc-surveillance-faq-259">[259]</a><a href="#cite_note-CDC-FAQ-90">[90]</a> Several similar but apparently distinct conditions may exist, caused by various species or subspecies of Borrelia in North America. A regionally restricted condition that may be related to Borrelia infection is <a href="/wiki/Southern_tick-associated_rash_illness" title="Southern tick-associated rash illness">southern tick-associated rash illness</a> (STARI), also known as Masters disease. <a href="/wiki/Amblyomma_americanum" title="Amblyomma americanum">Amblyomma americanum</a>, known commonly as the lone-star tick, is recognized as the primary vector for STARI. In some parts of the geographical distribution of STARI, Lyme disease is quite rare (e.g., Arkansas), so people in these regions experiencing Lyme-like symptoms—especially if they follow a bite from a lone-star tick—should consider STARI as a possibility. It is generally a milder condition than Lyme and typically responds well to antibiotic treatment.<a href="#cite_note-260">[260]</a> In recent years there have been 5 to 10 cases a year of a disease similar to Lyme occurring in Montana. It occurs primarily in pockets along the <a href="/wiki/Yellowstone_River" title="Yellowstone River">Yellowstone River</a> in central Montana. People have developed a red bull's-eye rash around a tick bite followed by weeks of fatigue and a fever.<a href="#cite_note-nytimes.com-256">[256]</a> <div class="mw-heading mw-heading3"><h3 id="South_America">South America</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=39" title="Edit section: South America">edit</a>]</div> In Brazil, Lyme disease is not considered endemic.<a href="#cite_note-BYS-2024-261">[261]</a> A Lyme-like disease known as <a href="/wiki/Baggio%E2%80%93Yoshinari_syndrome" title="Baggio–Yoshinari syndrome">Baggio–Yoshinari syndrome</a> has been described, attributed to microorganisms that do not belong to the B. burgdorferi sensu lato complex and transmitted by ticks of the <a href="/wiki/Amblyomma" title="Amblyomma">Amblyomma</a> and <a href="/wiki/Rhipicephalus" title="Rhipicephalus">Rhipicephalus</a> genera.<a href="#cite_note-Mantovani_2007-262">[262]</a> The first reported case of BYS in Brazil was made in 1992 in <a href="/wiki/Cotia" title="Cotia">Cotia</a>, São Paulo.<a href="#cite_note-Yoshinari_1993-263">[263]</a> A 2024 analysis concluded that evidence to connect BYS to Borrelia bacteria was lacking.<a href="#cite_note-BYS-2024-261">[261]</a> <div class="mw-heading mw-heading2"><h2 id="Etymology">Etymology</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=40" title="Edit section: Etymology">edit</a>]</div> Lyme disease was diagnosed as a separate condition for the first time in 1975 in <a href="/wiki/Lyme,_Connecticut" title="Lyme, Connecticut">Lyme, Connecticut</a>.<a href="#cite_note-264">[264]</a> <div class="mw-heading mw-heading2"><h2 id="History">History</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=41" title="Edit section: History">edit</a>]</div> The earliest known evidence of Lyme disease was found in <a href="/wiki/Oetzi" class="mw-redirect" title="Oetzi">Oetzi</a>, a 5300 year old mummy in the <a href="/wiki/Eastern_Alps" title="Eastern Alps">Eastern Alps</a> near the Italian border.<a href="#cite_note-265">[265]</a> The evolutionary history of Borrelia burgdorferi genetics has been examined by scientists. One study has found that prior to the <a href="/wiki/Reforestation" title="Reforestation">reforestation</a> that accompanied post-colonial farm abandonment in <a href="/wiki/New_England" title="New England">New England</a> and the wholesale migration into the <a href="/wiki/Mid-west" class="mw-redirect" title="Mid-west">mid-west</a> that occurred during the early 19th century Lyme disease had been present for thousands of years in America and had spread along with its tick hosts from the Northeast to the Midwest.<a href="#cite_note-Hoen_2009-266">[266]</a> John Josselyn, who visited New England in 1638 and again from 1663 to 1670, wrote "there be infinite numbers of ticks hanging upon the bushes in summertime that will cleave to man's garments and creep into his breeches, eating themselves in a short time into the very flesh of a man. I have seen the stockings of those that have gone through the woods covered with them."<a href="#cite_note-Josselyn_1670-267">[267]</a> This is also confirmed by the writings of <a href="/wiki/Peter_Kalm" class="mw-redirect" title="Peter Kalm">Peter Kalm</a>, a Swedish botanist who was sent to America by <a href="/wiki/Carl_Linnaeus" title="Carl Linnaeus">Linnaeus</a>, and who found the forests of New York "abound" with ticks when he visited in 1749. When Kalm's journey was retraced 100 years later, the forests were gone and the Lyme bacterium had probably become isolated to a few pockets along the northeast coast, Wisconsin, and Minnesota.<a href="#cite_note-Drymon_2008-268">[268]</a> Perhaps the first detailed description of what is now known as Lyme disease appeared in the writings of <a href="/wiki/John_Walker_(natural_historian)" title="John Walker (natural historian)">John Walker</a> after a visit to the island of <a href="/wiki/Jura,_Scotland" title="Jura, Scotland">Jura</a> (Deer Island) off the west coast of Scotland in 1764.<a href="#cite_note-summerton_1995-269">[269]</a> He gives a good description both of the symptoms of Lyme disease (with "exquisite pain [in] the interior parts of the limbs") and of the tick vector itself, which he describes as a "worm" with a body which is "of a reddish color and of a compressed shape with a row of feet on each side" that "penetrates the skin". Many people from this area of Great Britain emigrated to North America between 1717 and the end of the 18th century.<a href="#cite_note-270">[270]</a> The examination of preserved museum specimens has found Borrelia DNA in an infected <a href="/wiki/Ixodes_ricinus" title="Ixodes ricinus">Ixodes ricinus</a> tick from Germany that dates back to 1884, and from an infected mouse from Cape Cod that died in 1894.<a href="#cite_note-Drymon_2008-268">[268]</a> The 2010 autopsy of <a href="/wiki/%C3%96tzi_the_Iceman" class="mw-redirect" title="Ötzi the Iceman">Ötzi the Iceman</a>, a 5,300-year-old <a href="/wiki/Mummy" title="Mummy">mummy</a>, revealed the presence of the DNA sequence of Borrelia burgdorferi making him the earliest known human with Lyme disease.<a href="#cite_note-ngautopsy-271">[271]</a> The early European studies of what is now known as Lyme disease described its skin manifestations. The first study dates to 1883 in <a href="/wiki/Breslau" class="mw-redirect" title="Breslau">Breslau</a>, Germany (now <a href="/wiki/Wroc%C5%82aw" title="Wrocław">Wrocław</a>, Poland), where physician Alfred Buchwald described a man who for 16 years had had a degenerative <a href="/wiki/Skin_disorder" class="mw-redirect" title="Skin disorder">skin disorder</a> now known as <a href="/wiki/Acrodermatitis_chronica_atrophicans" title="Acrodermatitis chronica atrophicans">acrodermatitis chronica atrophicans</a>.<a href="#cite_note-Afzelius1910-272">[272]</a> At a 1909 research conference, Swedish dermatologist <a href="/wiki/Arvid_Afzelius" title="Arvid Afzelius">Arvid Afzelius</a> presented a study about an expanding, ring-like lesion he had observed in an older woman following the bite of a sheep tick. He named the lesion erythema migrans.<a href="#cite_note-Afzelius1910-272">[272]</a> The skin condition now known as <a href="/wiki/Borrelial_lymphocytoma" class="mw-redirect" title="Borrelial lymphocytoma">borrelial lymphocytoma</a> was first described in 1911.<a href="#cite_note-burckhardt_1911-273">[273]</a> The modern history of medical understanding of the disease, including its cause, diagnosis, and treatment, has been difficult.<a href="#cite_note-Edlow_2003-274">[274]</a> Neurological problems following tick bites were recognized starting in the 1920s. French physicians Garin and Bujadoux described a farmer with a painful sensory <a href="/wiki/Radiculitis" class="mw-redirect" title="Radiculitis">radiculitis</a> accompanied by mild <a href="/wiki/Meningitis" title="Meningitis">meningitis</a> following a tick bite. A large, ring-shaped rash was also noted, although the doctors did not relate it to the meningoradiculitis. In 1930, the Swedish dermatologist Sven Hellerström was the first to propose EM and neurological symptoms following a tick bite were related.<a href="#cite_note-hellerstrom_1930-275">[275]</a> In the 1940s, German neurologist <a href="/wiki/Alfred_Bannwarth" title="Alfred Bannwarth">Alfred Bannwarth</a> described several cases of chronic lymphocytic meningitis and polyradiculoneuritis, some of which were accompanied by erythematous skin lesions. Carl Lennhoff, who worked at the <a href="/wiki/Karolinska_Institute" title="Karolinska Institute">Karolinska Institute</a> in Sweden, believed many skin conditions were caused by spirochetes. In 1948, he published on his use of a special stain to microscopically observe what he believed were spirochetes in various types of skin lesions, including EM.<a href="#cite_note-lenhoff_1948-276">[276]</a> Although his conclusions were later shown to be erroneous, interest in the study of spirochetes was sparked.[<a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed">citation needed</a>] Starting in 1946, facilities in Sweden experimented with treating EM rashes with substances known to kill spirochetes.<a href="#cite_note-hollstrom-1951-277">[277]</a> <a href="/w/index.php?title=Einar_Hollstr%C3%B6m&action=edit&redlink=1" class="new" title="Einar Hollström (page does not exist)">Einar Hollström</a> [<a href="https://sv.wikipedia.org/wiki/Einar_Hollstr%C3%B6m" class="extiw" title="sv:Einar Hollström">sv</a>] reported that "penicillin was found to be the most effective."<a href="#cite_note-hollstrom-1958-278">[278]</a> In 1949, Nils Thyresson, who also worked at the Karolinska Institute, was the first to treat ACA with penicillin.<a href="#cite_note-pmid18140373-279">[279]</a> In the 1950s, the relationship among tick bite, lymphocytoma, EM and Bannwarth's syndrome was recognized throughout Europe leading to the widespread use of <a href="/wiki/Penicillin" title="Penicillin">penicillin</a> for treatment in Europe.<a href="#cite_note-Bianchi_1950-280">[280]</a><a href="#cite_note-Paschoud_1954-281">[281]</a> In 1970 a dermatologist in <a href="/wiki/Wisconsin" title="Wisconsin">Wisconsin</a> named Rudolph Scrimenti recognized an EM lesion in a person after recalling a paper by Hellerström that had been reprinted in an American science journal in 1950. This was the first documented case of EM in the United States. Based on the European literature, he treated the person with penicillin.<a href="#cite_note-Scrimenti_1970-282">[282]</a> The full <a href="/wiki/Syndrome" title="Syndrome">syndrome</a> now known as Lyme disease was not recognized until a cluster of cases originally thought to be <a href="/wiki/Juvenile_rheumatoid_arthritis" class="mw-redirect" title="Juvenile rheumatoid arthritis">juvenile rheumatoid arthritis</a> was identified in three towns in southeastern <a href="/wiki/Connecticut" title="Connecticut">Connecticut</a> in 1975, including the towns <a href="/wiki/Lyme,_Connecticut" title="Lyme, Connecticut">Lyme</a> and <a href="/wiki/Old_Lyme" class="mw-redirect" title="Old Lyme">Old Lyme</a>, which gave the disease its popular name.<a href="#cite_note-Borchers2015-283">[283]</a> This was investigated by physicians David Snydman and <a href="/wiki/Allen_Steere" title="Allen Steere">Allen Steere</a> of the <a href="/wiki/Epidemic_Intelligence_Service" title="Epidemic Intelligence Service">Epidemic Intelligence Service</a>, and by others from <a href="/wiki/Yale_University" title="Yale University">Yale University</a>, including <a href="/wiki/Stephen_Malawista" title="Stephen Malawista">Stephen Malawista</a>, who is credited as a co-discover of the disease.<a href="#cite_note-hcourant-284">[284]</a> The recognition that the people in the United States had EM led to the recognition that "Lyme arthritis" was one manifestation of the same tick-borne condition known in Europe.<a href="#cite_note-Sternbach-285">[285]</a> Before 1976, the elements of B. burgdorferi sensu lato infection were called or known as tick-borne meningopolyneuritis, Garin-Bujadoux syndrome, Bannwarth syndrome, Afzelius's disease,<a href="#cite_note-Bolognia-286">[286]</a> <a href="/wiki/Montauk,_New_York" title="Montauk, New York">Montauk Knee</a> or sheep tick fever. Since 1976 the disease is most often referred to as Lyme disease,<a href="#cite_note-Mast_1976-287">[287]</a><a href="#cite_note-Steere_1977-288">[288]</a> Lyme borreliosis or simply borreliosis.<a href="#cite_note-289">[289]</a><a href="#cite_note-290">[290]</a> In 1980, Steere, et al., began to test <a href="/wiki/Antibiotics" class="mw-redirect" title="Antibiotics">antibiotic</a> regimens in adults with Lyme disease.<a href="#cite_note-Steere_1983-291">[291]</a> In the same year, New York State Health Dept. epidemiologist <a href="/wiki/Jorge_Benach" title="Jorge Benach">Jorge Benach</a> provided <a href="/wiki/Willy_Burgdorfer" title="Willy Burgdorfer">Willy Burgdorfer</a>, a researcher at the <a href="/wiki/Rocky_Mountain_Biological_Laboratory" title="Rocky Mountain Biological Laboratory">Rocky Mountain Biological Laboratory</a>, with collections of I. dammini [scapularis] from Shelter Island, New York, a known Lyme-endemic area as part of an ongoing investigation of Rocky Mountain spotted fever. In examining the ticks for rickettsiae, Burgdorfer noticed "poorly stained, rather long, irregularly coiled spirochetes." Further examination revealed spirochetes in 60% of the ticks. Burgdorfer credited his familiarity with the European literature for his realization that the spirochetes might be the "long-sought cause of ECM and Lyme disease." Benach supplied him with more ticks from Shelter Island and <a href="/wiki/Blood_serum" class="mw-redirect" title="Blood serum">sera</a> from people diagnosed with Lyme disease. University of Texas Health Science Center researcher Alan Barbour "offered his expertise to culture and immunochemically characterize the organism." Burgdorfer subsequently confirmed his discovery by isolating, from people with Lyme disease, spirochetes identical to those found in ticks.<a href="#cite_note-Burgdorfer_1984-292">[292]</a> In June 1982, he published his findings in <a href="/wiki/Science_(journal)" title="Science (journal)">Science</a>, and the spirochete was named Borrelia burgdorferi in his honor.<a href="#cite_note-Burgdorfer_1982-293">[293]</a> After the identification of B. burgdorferi as the causative agent of Lyme disease, antibiotics were selected for testing, guided by in vitro antibiotic sensitivities, including <a href="/wiki/Tetracycline_antibiotics" title="Tetracycline antibiotics">tetracycline antibiotics</a>, <a href="/wiki/Amoxicillin" title="Amoxicillin">amoxicillin</a>, <a href="/wiki/Cefuroxime_axetil" title="Cefuroxime axetil">cefuroxime axetil</a>, intravenous and intramuscular penicillin and intravenous <a href="/wiki/Ceftriaxone" title="Ceftriaxone">ceftriaxone</a>.<a href="#cite_note-Luft_1988-294">[294]</a><a href="#cite_note-Dattwyler_1990-295">[295]</a> The mechanism of tick transmission was also the subject of much discussion. B. burgdorferi spirochetes were identified in tick saliva in 1987, confirming the hypothesis that transmission occurred via tick salivary glands.<a href="#cite_note-Ribeiro_1987-296">[296]</a> <div class="mw-heading mw-heading2"><h2 id="Society,_culture,_and_controversy">Society, culture, and controversy</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=42" title="Edit section: Society, culture, and controversy">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Landscape_changes_and_urbanization">Landscape changes and urbanization</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=43" title="Edit section: Landscape changes and urbanization">edit</a>]</div> Urbanization and other <a href="/wiki/Human_impact_on_the_environment" title="Human impact on the environment">anthropogenic</a> factors can be implicated in the spread of Lyme disease to humans. In many areas, expansion of suburban neighborhoods has led to gradual deforestation of surrounding wooded areas and increased border contact between humans and tick-dense areas. Human expansion has also resulted in a reduction of predators that hunt deer as well as mice, chipmunks and other small rodents—the primary reservoirs for Lyme disease. As a consequence of increased human contact with host and <a href="/wiki/Vector_(epidemiology)" class="mw-redirect" title="Vector (epidemiology)">vector</a>, the likelihood of transmission of the disease has greatly increased.<a href="#cite_note-The_ecology_of_infectious_disease-297">[297]</a><a href="#cite_note-Patz-298">[298]</a> Researchers are investigating possible links between <a href="/wiki/Global_warming" class="mw-redirect" title="Global warming">global warming</a> and the spread of vector-borne diseases, including Lyme disease.<a href="#cite_note-Khasnis-299">[299]</a> <div class="mw-heading mw-heading3"><h3 id="The_dilution_effect">The dilution effect</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=44" title="Edit section: The dilution effect">edit</a>]</div> Given these habitat-host dynamics, in 2003 some researchers began to postulate whether the so called dilution effect could mitigate the spread of Lyme disease.<a href="#cite_note-The_ecology_of_infectious_disease-297">[297]</a> The dilution effect is a hypothesis that predicts that an increase in host biodiversity will result in a decrease in the number of vectors infected with B. burgdorferi.<a href="#cite_note-The_ecology_of_infectious_disease-297">[297]</a> Scientific research has shown that nymphal infection prevalence (NIP) decreases as the number of host species increases, supporting the dilution effect.<a href="#cite_note-The_ecology_of_infectious_disease-297">[297]</a> That said, there is no direct relationship between decreased NIP and decreased epidemiological risk, as this has yet to be proven.<a href="#cite_note-The_ecology_of_infectious_disease-297">[297]</a> Additionally, as of 2018, the dilution effect is only supported in the Northeastern United States, and has been disproved in other parts of the world that also experience high Lyme disease incidence rates <a href="#cite_note-300">[300]</a> <div class="mw-heading mw-heading3"><h3 id="Chronic_Lyme_disease">Chronic Lyme disease</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=45" title="Edit section: Chronic Lyme disease">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Chronic_Lyme_disease" title="Chronic Lyme disease">Chronic Lyme disease</a></div> The term "chronic Lyme disease" is controversial and not recognized in the medical literature,<a href="#cite_note-nejm-feder-301">[301]</a> and most medical authorities advise against long-term antibiotic treatment for Lyme disease.<a href="#cite_note-idsa_guideline-35">[35]</a><a href="#cite_note-pmid17522387-120">[120]</a><a href="#cite_note-nih-cld-302">[302]</a> Studies have shown that most people diagnosed with "chronic Lyme disease" either have no objective evidence of previous or current infection with <a href="/wiki/B._burgdorferi" class="mw-redirect" title="B. burgdorferi">B. burgdorferi</a> or are people who should be classified as having post-treatment Lyme disease syndrome (PTLDS), which is defined as continuing or relapsing <a href="/wiki/Non-specific_symptoms" class="mw-redirect" title="Non-specific symptoms">non-specific symptoms</a> (such as fatigue, musculoskeletal pain, and cognitive complaints) in a person previously treated for Lyme disease.<a href="#cite_note-Marques-303">[303]</a> The 2008 documentary <a href="/wiki/Under_Our_Skin" title="Under Our Skin">Under Our Skin</a> is known for promoting controversial and unrecognized theories about "chronic Lyme disease".<a href="#cite_note-under-our-skin-sbm-304">[304]</a> <div class="mw-heading mw-heading2"><h2 id="Other_animals">Other animals</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=46" title="Edit section: Other animals">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Dogs">Dogs</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=47" title="Edit section: Dogs">edit</a>]</div> Prevention of Lyme disease is an important step in keeping dogs safe in endemic areas. Prevention education and a number of preventive measures are available. First, for dog owners who live near or who often frequent tick-infested areas, routine vaccinations of their dogs is an important step.<a href="#cite_note-pmid20207198-305">[305]</a> Another crucial preventive measure is the use of persistent acaricides, such as topical repellents or pesticides that contain triazapentadienes (<a href="/wiki/Amitraz" title="Amitraz">Amitraz</a>), phenylpyrazoles (<a href="/wiki/Fipronil" title="Fipronil">Fipronil</a>), or permethrin (<a href="/wiki/Pyrethroids" class="mw-redirect" title="Pyrethroids">pyrethroids</a>).<a href="#cite_note-pmid20933139-306">[306]</a> These acaricides target primarily the adult stages of Lyme-carrying ticks and reduce the number of reproductively active ticks in the environment.<a href="#cite_note-pmid20207198-305">[305]</a> Formulations of these ingredients are available in a variety of topical forms, including spot-ons, sprays, powders, impregnated collars, solutions, and shampoos.<a href="#cite_note-pmid20933139-306">[306]</a> Examination of a dog for ticks after being in a tick-infested area is an important precautionary measure to take in the prevention of Lyme disease. Key spots to examine include the head, neck, and ears.<a href="#cite_note-hahn-307">[307]</a> In dogs, a serious long-term prognosis may result in glomerular disease,<a href="#cite_note-merck_2012-308">[308]</a> which is a category of kidney damage that may cause chronic kidney disease.<a href="#cite_note-Brooks,_DVM-190">[190]</a> Dogs may also experience chronic joint disease if the disease is left untreated. However, the majority of cases of Lyme disease in dogs result in complete recovery with, and sometimes without, treatment with antibiotics.<a href="#cite_note-staubinger-309">[309]</a>[<a href="/wiki/Wikipedia:Verifiability" title="Wikipedia:Verifiability">verification needed</a>] In rare cases, Lyme disease can be fatal to both humans and dogs.<a href="#cite_note-fatal-cases-310">[310]</a> <div class="mw-heading mw-heading3"><h3 id="Cats">Cats</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=48" title="Edit section: Cats">edit</a>]</div> Unlike dogs, it is very rare for a cat to be infected with Lyme disease. However, cats are nevertheless capable of being infected with <a href="/wiki/Borrelia_burgdorferi" title="Borrelia burgdorferi">B. burgdorferi</a> , following a bite from an infected tick. Cats who are infected with Lyme Disease may show symptoms including but not limited to lameness, fatigue, or loss of appetite.<a href="#cite_note-Merck_Veterinary_Manual-311">[311]</a> In two cases, the infected cats experienced cardiac irregularities similar to symptoms of Lyme in both dogs and humans.<a href="#cite_note-Tørnqvist-Johnsen_2020-312">[312]</a> However, cats who are infected with Lyme disease are likely to be <a href="/wiki/Asymptomatic" title="Asymptomatic">asymptomatic</a>, and show no noticeable signs of the disease.<a href="#cite_note-Tørnqvist-Johnsen_2020-312">[312]</a><a href="#cite_note-Merck_Veterinary_Manual-311">[311]</a> Cats with Lyme are often treated with antibiotics, much like other animals. In some cases, additional treatment or therapy may be required.<a href="#cite_note-Merck_Veterinary_Manual-311">[311]</a> <div class="mw-heading mw-heading3"><h3 id="Horses">Horses</h3>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=49" title="Edit section: Horses">edit</a>]</div> Lyme disease in horses is often challenging to diagnose because symptoms vary widely. Common acute symptoms include weight loss, fever, <a href="/wiki/Lameness_(equine)" title="Lameness (equine)">lameness</a>, <a href="/wiki/Ataxia" title="Ataxia">ataxia</a>, and other muscle and joint-related issues.<a href="#cite_note-:02-313">[313]</a><a href="#cite_note-:12-314">[314]</a><a href="#cite_note-315">[315]</a> Additional symptoms include muscle tenderness, swollen joints, <a href="/wiki/Arthritis" title="Arthritis">arthritis</a>, and neck stiffness.<a href="#cite_note-:2-316">[316]</a><a href="#cite_note-:3-317">[317]</a><a href="#cite_note-318">[318]</a> Chronic symptoms of the disease typically include neurological manifestations, such as <a href="/wiki/Meningitis" title="Meningitis">meningitis</a>, cranial neuritis, <a href="/wiki/Radiculoneuritis" class="mw-redirect" title="Radiculoneuritis">radiculoneuritis</a>, and <a href="/wiki/Encephalitis" title="Encephalitis">encephalitis</a>.<a href="#cite_note-319">[319]</a><a href="#cite_note-:02-313">[313]</a><a href="#cite_note-:4-320">[320]</a><a href="#cite_note-321">[321]</a> Furthermore, it is important to note that some horses do not slow clinical signs of Lyme disease.<a href="#cite_note-:5-322">[322]</a> There are three main testing strategies used to diagnose horses with Lyme disease. They include clinical evaluation, <a href="/wiki/Serological_testing" class="mw-redirect" title="Serological testing">serological testing</a>, and <a href="/wiki/Polymerase_chain_reaction" title="Polymerase chain reaction">polymerase chain reaction</a> (PCR) testing.<a href="#cite_note-323">[323]</a><a href="#cite_note-324">[324]</a><a href="#cite_note-:12-314">[314]</a> Detection of <a href="/wiki/Antibody" title="Antibody">specific antibodies</a> against B. burgdorferi alone is not sufficient for a diagnosis of <a href="/wiki/Equinae" title="Equinae">equine</a> Lyme disease and unspecific testing for antibodies is not recommended.<a href="#cite_note-325">[325]</a> Typical treatment involves antibiotics such as <a href="/wiki/Oxytetracycline" title="Oxytetracycline">oxytetracycline</a>, <a href="/wiki/Doxycycline" title="Doxycycline">doxycycline</a>, <a href="/wiki/Ceftriaxone" title="Ceftriaxone">ceftriaxone</a>, or <a href="/wiki/Minocycline" title="Minocycline">minocycline</a>.<a href="#cite_note-326">[326]</a><a href="#cite_note-:6-327">[327]</a><a href="#cite_note-:5-322">[322]</a> In some cases, a combination of antibiotics may be administered. Doxycycline and minocycline are taken orally, while oxytetracycline and ceftriaxone are usually administered intravenously.<a href="#cite_note-:6-327">[327]</a><a href="#cite_note-328">[328]</a><a href="#cite_note-:5-322">[322]</a> The duration and dosage of treatment vary widely among cases. In most cases, the infected horse is <a href="/wiki/Euthanized" class="mw-redirect" title="Euthanized">euthanized</a>.<a href="#cite_note-:2-316">[316]</a><a href="#cite_note-:3-317">[317]</a><a href="#cite_note-:4-320">[320]</a><a href="#cite_note-329">[329]</a> Death of horses as a result of Borrelia burgdorferi infection remains unknown.<a href="#cite_note-330">[330]</a>. Currently, there is no approved Lyme disease vaccine for horses available.<a href="#cite_note-:7-331">[331]</a> However, a study demonstrated that ponies could be protected using an aluminum adjuvanted recombinant <a href="/wiki/Outer_surface_protein" class="mw-redirect" title="Outer surface protein">outer-surface protein</a> A (rOspA) vaccine.<a href="#cite_note-332">[332]</a> While horses have been administered a Lyme disease vaccine designed for dogs, it elicits only a short-lasting antibody response.<a href="#cite_note-:7-331">[331]</a> Another study supports the use of commercial Lyme disease vaccines, showing that they do elicit an antibody response, which can be significantly enhanced when horses receive an additional booster vaccine.<a href="#cite_note-333">[333]</a> <div class="mw-heading mw-heading2"><h2 id="References">References</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=50" title="Edit section: References">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-CDC2013S-1">^ <a href="#cite_ref-CDC2013S_1-0">a</a> <a href="#cite_ref-CDC2013S_1-1">b</a> <a href="#cite_ref-CDC2013S_1-2">c</a> <a href="#cite_ref-CDC2013S_1-3">d</a> <a href="#cite_ref-CDC2013S_1-4">e</a> <a href="#cite_ref-CDC2013S_1-5">f</a> <a href="#cite_ref-CDC2013S_1-6">g</a> <a href="#cite_ref-CDC2013S_1-7">h</a> <a href="#cite_ref-CDC2013S_1-8">i</a> <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20130116063305/http://www.cdc.gov/lyme/signs_symptoms/index.html">"Signs and Symptoms of Lyme Disease"</a>. cdc.gov. 11 January 2013. 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In Baron S, et al. (eds.). Baron's Medical Microbiology (4th ed.). 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Retrieved 29 September 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=ECDC&rft.atitle=Lyme+borreliosis&rft_id=https%3A%2F%2Fecdc.europa.eu%2Fsites%2Fportal%2Ffiles%2Fmedia%2Fen%2Fhealthtopics%2Femerging_and_vector-borne_diseases%2Ftick_borne_diseases%2Fpublic_health_measures%2FDocuments%2FHCP_factsheet_LB_highres.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"> </li> <li id="cite_note-Lancet2016-16">^ <a href="#cite_ref-Lancet2016_16-0">a</a> <a href="#cite_ref-Lancet2016_16-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPrittMeadJohnsonNeitzel2016" class="citation journal cs1">Pritt BS, Mead PS, Johnson DK, Neitzel DF, Respicio-Kingry LB, Davis JP, et al. (May 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975683">"Identification of a novel pathogenic Borrelia species causing Lyme borreliosis with unusually high spirochaetaemia: a descriptive study"</a>. The Lancet. Infectious Diseases. 16 (5): 556–564. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1473-3099%2815%2900464-8">10.1016/S1473-3099(15)00464-8</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975683">4975683</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26856777">26856777</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Lancet.+Infectious+Diseases&rft.atitle=Identification+of+a+novel+pathogenic+Borrelia+species+causing+Lyme+borreliosis+with+unusually+high+spirochaetaemia%3A+a+descriptive+study&rft.volume=16&rft.issue=5&rft.pages=556-564&rft.date=2016-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4975683%23id-name%3DPMC&rft_id=info%3Apmid%2F26856777&rft_id=info%3Adoi%2F10.1016%2FS1473-3099%2815%2900464-8&rft.aulast=Pritt&rft.aufirst=BS&rft.au=Mead%2C+PS&rft.au=Johnson%2C+DK&rft.au=Neitzel%2C+DF&rft.au=Respicio-Kingry%2C+LB&rft.au=Davis%2C+JP&rft.au=Schiffman%2C+E&rft.au=Sloan%2C+LM&rft.au=Schriefer%2C+ME&rft.au=Replogle%2C+AJ&rft.au=Paskewitz%2C+SM&rft.au=Ray%2C+JA&rft.au=Bjork%2C+J&rft.au=Steward%2C+CR&rft.au=Deedon%2C+A&rft.au=Lee%2C+X&rft.au=Kingry%2C+LC&rft.au=Miller%2C+TK&rft.au=Feist%2C+MA&rft.au=Theel%2C+ES&rft.au=Patel%2C+R&rft.au=Irish%2C+CL&rft.au=Petersen%2C+JM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4975683&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"> </li> <li id="cite_note-17"><a href="#cite_ref-17">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.cdc.gov/lyme/diagnosistesting/LabTest/TwoStep/index.html">"Two-step Laboratory Testing Process"</a>. cdc.gov. 15 November 2011. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20150312123313/http://www.cdc.gov/lyme/diagnosistesting/labtest/twostep/index.html">Archived</a> from the original on 12 March 2015. Retrieved 2 March 2015.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=cdc.gov&rft.atitle=Two-step+Laboratory+Testing+Process&rft.date=2011-11-15&rft_id=https%3A%2F%2Fwww.cdc.gov%2Flyme%2Fdiagnosistesting%2FLabTest%2FTwoStep%2Findex.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"> </li> <li id="cite_note-18"><a href="#cite_ref-18">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.cdc.gov/lyme/diagnosistesting/LabTest/Testing/index.html">"Testing of Ticks"</a>. cdc.gov. 4 June 2013. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20150219183735/http://www.cdc.gov/lyme/diagnosistesting/LabTest/Testing/index.html">Archived</a> from the original on 19 February 2015. Retrieved 2 March 2015. <q>Although some commercial groups offer testing, in general it is not recommended</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=cdc.gov&rft.atitle=Testing+of+Ticks&rft.date=2013-06-04&rft_id=https%3A%2F%2Fwww.cdc.gov%2Flyme%2Fdiagnosistesting%2FLabTest%2FTesting%2Findex.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"> </li> <li id="cite_note-19"><a href="#cite_ref-19">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.cdc.gov/lyme/removal/index.html">"Tick Removal"</a>. cdc.gov. 23 June 2014. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20150310141610/http://www.cdc.gov/lyme/removal/index.html">Archived</a> from the original on 10 March 2015. 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Retrieved 20 June 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=cdc.gov&rft.atitle=Post-Treatment+Lyme+Disease+Syndrome&rft.date=2017-12-01&rft_id=https%3A%2F%2Fwww.cdc.gov%2Flyme%2FpostLDS%2Findex.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"> </li> <li id="cite_note-21"><a href="#cite_ref-21">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation book cs1"><a rel="nofollow" class="external text" href="https://books.google.com/books?id=Hpr10wAwoE0C&pg=PA136">Regional Disease Vector Ecology Profile: Central Europe</a>. DIANE Publishing. April 2001. p. 136. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-4289-1143-7" title="Special:BookSources/978-1-4289-1143-7"><bdi>978-1-4289-1143-7</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170908151350/https://books.google.com/books?id=Hpr10wAwoE0C&pg=PA136">Archived</a> from the original on 8 September 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Regional+Disease+Vector+Ecology+Profile%3A+Central+Europe&rft.pages=136&rft.pub=DIANE+Publishing&rft.date=2001-04&rft.isbn=978-1-4289-1143-7&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DHpr10wAwoE0C%26pg%3DPA136&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"> </li> <li id="cite_note-Car2007-22"><a href="#cite_ref-Car2007_22-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWilliams2007" class="citation book cs1">Williams C (2007). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=o_j-G4zJ4cQC&pg=PA447">Infectious disease epidemiology : theory and practice</a> (2nd ed.). 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Vaccine. 18 (5): 540–548. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0264-410X%2899%2900187-5">10.1016/S0264-410X(99)00187-5</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0264-410X">0264-410X</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Vaccination+against+Lyme+Disease+with+recombinant+Borrelia+burgdorferi+outer-surface+protein+A+%28rOspA%29+in+horses&rft.volume=18&rft.issue=5&rft.pages=540-548&rft.date=1999&rft_id=info%3Adoi%2F10.1016%2FS0264-410X%2899%2900187-5&rft.issn=0264-410X&rft.aulast=Chang&rft.aufirst=Y.+F.&rft.au=Novosol%2C+V.&rft.au=McDonough%2C+S.+P.&rft.au=Chang%2C+C.+F.&rft.au=Jacobson%2C+R.+H.&rft.au=Divers%2C+T.&rft.au=Quimby%2C+F.+W.&rft.au=Shin%2C+S.&rft.au=Lein%2C+D.+H.&rft_id=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS0264410X99001875&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"> </li> <li id="cite_note-333"><a href="#cite_ref-333">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKnödlsederFellStraubinger2019" class="citation journal cs1">Knödlseder JM, Fell SF, Straubinger RK (2019). <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/31635975/">"A study with a commercial vaccine against Lyme borreliosis in horses using two different vaccination schedules: Characterization of the humoral immune response"</a>. Vaccine. 37 (49): 7207–7212.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=A+study+with+a+commercial+vaccine+against+Lyme+borreliosis+in+horses+using+two+different+vaccination+schedules%3A+Characterization+of+the+humoral+immune+response&rft.volume=37&rft.issue=49&rft.pages=7207-7212&rft.date=2019&rft.aulast=Kn%C3%B6dlseder&rft.aufirst=J.+M.&rft.au=Fell%2C+S.+F.&rft.au=Straubinger%2C+R.+K.&rft_id=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F31635975%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"> </li> </ol></div></div> <img alt="Public Domain" src="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/12px-PD-icon.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/18px-PD-icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/24px-PD-icon.svg.png 2x" data-file-width="196" data-file-height="196" /> This article incorporates <a href="/wiki/Copyright_status_of_works_by_the_federal_government_of_the_United_States" title="Copyright status of works by the federal government of the United States">public domain material</a> from <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation cs1"><a rel="nofollow" class="external text" href="https://www.cdc.gov/lyme/postLDS/index.html">Post-Treatment Lyme Disease Syndrome</a>. <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">Centers for Disease Control and Prevention</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Post-Treatment+Lyme+Disease+Syndrome&rft.pub=Centers+for+Disease+Control+and+Prevention&rft_id=https%3A%2F%2Fwww.cdc.gov%2Flyme%2FpostLDS%2Findex.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=51" title="Edit section: Further reading">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOstfeld2012" class="citation book cs1">Ostfeld R (2012). Lyme Disease: The Ecology of a Complex System. New York: <a href="/wiki/Oxford_University_Press" title="Oxford University Press">Oxford University Press</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-19-992847-7" title="Special:BookSources/978-0-19-992847-7"><bdi>978-0-19-992847-7</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Lyme+Disease%3A+The+Ecology+of+a+Complex+System&rft.place=New+York&rft.pub=Oxford+University+Press&rft.date=2012&rft.isbn=978-0-19-992847-7&rft.aulast=Ostfeld&rft.aufirst=R&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBarbour2015" class="citation book cs1">Barbour AG (2015). Lyme disease: why it's spreading, how it makes you sick, and what to do about it. Baltimore: Johns Hopkins University Press. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-4214-1721-9" title="Special:BookSources/978-1-4214-1721-9"><bdi>978-1-4214-1721-9</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Lyme+disease%3A+why+it%27s+spreading%2C+how+it+makes+you+sick%2C+and+what+to+do+about+it&rft.place=Baltimore&rft.pub=Johns+Hopkins+University+Press&rft.date=2015&rft.isbn=978-1-4214-1721-9&rft.aulast=Barbour&rft.aufirst=AG&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHalperin2018" class="citation book cs1">Halperin JJ, ed. (2018). Lyme disease: an evidence-based approach (2nd ed.). Wallingford, Oxfordshire, UK: CABI. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-78639-207-7" title="Special:BookSources/978-1-78639-207-7"><bdi>978-1-78639-207-7</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Lyme+disease%3A+an+evidence-based+approach&rft.place=Wallingford%2C+Oxfordshire%2C+UK&rft.edition=2nd&rft.pub=CABI&rft.date=2018&rft.isbn=978-1-78639-207-7&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRadolfSamuels2021" class="citation book cs1">Radolf JD, Samuels DS, eds. (2021). <a rel="nofollow" class="external text" href="https://www.caister.com/lyme">Lyme disease and relapsing fever spirochetes: genomics, molecular biology, host interactions and disease pathogenesis</a>. Poole, UK: Caister. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-913652-61-6" title="Special:BookSources/978-1-913652-61-6"><bdi>978-1-913652-61-6</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Lyme+disease+and+relapsing+fever+spirochetes%3A+genomics%2C+molecular+biology%2C+host+interactions+and+disease+pathogenesis&rft.place=Poole%2C+UK&rft.pub=Caister&rft.date=2021&rft.isbn=978-1-913652-61-6&rft_id=https%3A%2F%2Fwww.caister.com%2Flyme&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOaklander2021" class="citation web cs1">Oaklander M (17 June 2021). <a rel="nofollow" class="external text" href="https://time.com/6073576/lyme-disease-vaccine/">"We Used to Have a Lyme Disease Vaccine. Are We Ready to Bring One Back?"</a>. <a href="/wiki/Time_(magazine)" title="Time (magazine)">Time</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Time&rft.atitle=We+Used+to+Have+a+Lyme+Disease+Vaccine.+Are+We+Ready+to+Bring+One+Back%3F&rft.date=2021-06-17&rft.aulast=Oaklander&rft.aufirst=M&rft_id=https%3A%2F%2Ftime.com%2F6073576%2Flyme-disease-vaccine%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyme+disease" class="Z3988"></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2>[<a href="/w/index.php?title=Lyme_disease&action=edit&section=52" title="Edit section: External links">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1235681985">.mw-parser-output .side-box{margin:4px 0;box-sizing:border-box;border:1px solid #aaa;font-size:88%;line-height:1.25em;background-color:var(--background-color-interactive-subtle,#f8f9fa);display:flow-root}.mw-parser-output .side-box-abovebelow,.mw-parser-output .side-box-text{padding:0.25em 0.9em}.mw-parser-output .side-box-image{padding:2px 0 2px 0.9em;text-align:center}.mw-parser-output .side-box-imageright{padding:2px 0.9em 2px 0;text-align:center}@media(min-width:500px){.mw-parser-output .side-box-flex{display:flex;align-items:center}.mw-parser-output .side-box-text{flex:1;min-width:0}}@media(min-width:720px){.mw-parser-output .side-box{width:238px}.mw-parser-output .side-box-right{clear:right;float:right;margin-left:1em}.mw-parser-output .side-box-left{margin-right:1em}}</style><style data-mw-deduplicate="TemplateStyles:r1237033735">@media print{body.ns-0 .mw-parser-output .sistersitebox{display:none!important}}@media screen{html.skin-theme-clientpref-night .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}</style><div class="side-box side-box-right plainlinks sistersitebox"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style> <div class="side-box-flex"> <div class="side-box-image"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/30px-Commons-logo.svg.png" decoding="async" width="30" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/45px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/59px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></div> <div class="side-box-text plainlist">Wikimedia Commons has media related to <a href="https://commons.wikimedia.org/wiki/Category:Borreliosis" class="extiw" title="commons:Category:Borreliosis">Borreliosis</a>.</div></div> </div> <ul><li><a rel="nofollow" class="external text" href="https://www.cdc.gov/lyme/">CDC - Lyme Disease</a></li> <li><a rel="nofollow" class="external text" href="https://www.aphl.org/aboutAPHL/publications/Documents/ID-2021-Lyme-Disease-Serologic-Testing-Reporting.pdf">Association for Public Health Laboratories guide</a> – Suggested Reporting Language, Interpretation and Guidance Regarding Lyme Disease Serologic Test Results</li> <li><a rel="nofollow" class="external text" href="https://www.niaid.nih.gov/diseases-conditions/lyme-disease">NIH – Lyme Disease</a></li> <li><a rel="nofollow" class="external text" href="https://www.nice.org.uk/guidance/ng95/chapter/Recommendations">NICE Guidelines – Lyme Disease</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output 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dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"></div><div role="navigation" class="navbox" aria-label="Navbox" style="width:100%; margin:0.5em 0 0.5em 0;;padding:3px"><table class="nowraplinks navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q201989" class="extiw" title="d:Q201989">D</a></div><div class="hlist" style="text-align:left;"><ul><li><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/ICD-11" title="ICD-11">11</a>: <a rel="nofollow" class="external text" href="https://icd.who.int/browse/latest-release/mms/en#1600014919">1C1G</a></li><li><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/ICD-10" title="ICD-10">10</a>: <a rel="nofollow" class="external text" href="https://icd.who.int/browse10/2019/en#/A69.2">A69.2</a></li><li><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/ICD-10-CM" title="ICD-10-CM">10-CM</a>: <a rel="nofollow" class="external text" href="https://icd10cmtool.cdc.gov/?fy=FY2024&query=A69.2">A69.2</a></li><li><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/List_of_ICD-9_codes" title="List of ICD-9 codes">9-CM</a>: <a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=088.81">088.81</a></li><li><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a>: <a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D008193">D008193</a></li><li><a href="/wiki/Diseases_Database" title="Diseases Database">DiseasesDB</a>: <a rel="nofollow" class="external text" href="http://www.diseasesdatabase.com/ddb1531.htm">1531</a></li></ul></div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">External resources</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist" style="text-align:left;"><ul><li><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a>: <a rel="nofollow" class="external text" href="https://www.nlm.nih.gov/medlineplus/ency/article/001319.htm">001319</a></li><li><a href="/wiki/Patient_UK" title="Patient UK">Patient UK</a>: <a rel="nofollow" class="external text" href="https://patient.info/doctor/lyme-disease-pro">Lyme disease</a></li><li>Scholia: <a class="external text" href="https://tools.wmflabs.org/scholia/topic/Q201989">Q201989</a></li></ul></div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Tick-borne_diseases_and_infestations" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar 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href="/wiki/Template:Tick-borne_diseases_and_infestations" title="Template:Tick-borne diseases and infestations"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Tick-borne_diseases_and_infestations" title="Template talk:Tick-borne diseases and infestations"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Tick-borne_diseases_and_infestations" title="Special:EditPage/Template:Tick-borne diseases and infestations"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Tick-borne_diseases_and_infestations" style="font-size:114%;margin:0 4em"><a href="/wiki/Tick-borne_disease" title="Tick-borne disease">Tick-borne diseases</a> and infestations</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Diseases</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Bacterial_infection" class="mw-redirect" title="Bacterial infection">Bacterial infections</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Rickettsiales" title="Rickettsiales">Rickettsiales</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anaplasmosis" title="Anaplasmosis">Anaplasmosis</a></li> <li><a href="/wiki/Boutonneuse_fever" title="Boutonneuse fever">Boutonneuse fever</a></li> <li><a href="/wiki/Ehrlichiosis" title="Ehrlichiosis">Ehrlichiosis</a> (<a href="/wiki/Human_granulocytic_anaplasmosis" title="Human granulocytic anaplasmosis">Human granulocytic</a>, <a href="/wiki/Human_monocytotropic_ehrlichiosis" title="Human monocytotropic ehrlichiosis">Human monocytotropic</a>, <a href="/wiki/Ehrlichiosis_ewingii_infection" title="Ehrlichiosis ewingii infection">Human E. ewingii infection</a>)</li> <li><a href="/wiki/Scrub_typhus" title="Scrub typhus">Scrub typhus</a></li> <li><a href="/wiki/Spotted_fever_rickettsiosis" title="Spotted fever rickettsiosis">Spotted fever rickettsiosis</a> <ul><li><a href="/wiki/Pacific_Coast_tick_fever" title="Pacific Coast tick fever">Pacific Coast tick fever</a></li> <li><a href="/wiki/American_tick_bite_fever" class="mw-redirect" title="American tick bite fever">American tick bite fever</a></li> <li><a href="/wiki/Rickettsialpox" title="Rickettsialpox">rickettsialpox</a></li> <li><a href="/wiki/Rocky_Mountain_spotted_fever" title="Rocky Mountain spotted fever">Rocky Mountain spotted fever</a>)</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Spirochaete" title="Spirochaete">Spirochaete</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Baggio%E2%80%93Yoshinari_syndrome" title="Baggio–Yoshinari syndrome">Baggio–Yoshinari syndrome</a></li> <li><a class="mw-selflink selflink">Lyme disease</a></li> <li><a href="/wiki/Relapsing_fever_borreliosis" class="mw-redirect" title="Relapsing fever borreliosis">Relapsing fever borreliosis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Thiotrichales" title="Thiotrichales">Thiotrichales</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tularemia" title="Tularemia">Tularemia</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Viral_infection" class="mw-redirect" title="Viral infection">Viral infections</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bhanja_virus" title="Bhanja virus">Bhanja virus</a></li> <li><a href="/wiki/Bourbon_virus" title="Bourbon virus">Bourbon virus</a></li> <li><a href="/wiki/Colorado_tick_fever" title="Colorado tick fever">Colorado tick fever</a></li> <li><a href="/wiki/Crimean%E2%80%93Congo_hemorrhagic_fever" title="Crimean–Congo hemorrhagic fever">Crimean–Congo hemorrhagic fever</a></li> <li><a href="/wiki/Heartland_bandavirus" title="Heartland bandavirus">Heartland bandavirus</a></li> <li><a href="/wiki/Kemerovo_tickborne_viral_fever" title="Kemerovo tickborne viral fever">Kemerovo tickborne viral fever</a></li> <li><a href="/wiki/Kyasanur_Forest_disease" title="Kyasanur Forest disease">Kyasanur Forest disease</a></li> <li><a href="/wiki/Omsk_hemorrhagic_fever" title="Omsk hemorrhagic fever">Omsk hemorrhagic fever</a></li> <li><a href="/wiki/Powassan_encephalitis" title="Powassan encephalitis">Powassan encephalitis</a></li> <li><a href="/wiki/Severe_fever_with_thrombocytopenia_syndrome" title="Severe fever with thrombocytopenia syndrome">Severe fever with thrombocytopenia syndrome</a></li> <li><a href="/wiki/Tete_orthobunyavirus" title="Tete orthobunyavirus">Tete orthobunyavirus</a></li> <li><a href="/wiki/Tick-borne_encephalitis" title="Tick-borne encephalitis">Tick-borne encephalitis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Protozoan_infection" title="Protozoan infection">Protozoan infections</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Babesiosis" title="Babesiosis">Babesiosis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other diseases</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tick_paralysis" title="Tick paralysis">Tick paralysis</a></li> <li><a href="/wiki/Alpha-gal_allergy" class="mw-redirect" title="Alpha-gal allergy">Alpha-gal allergy</a></li> <li><a href="/wiki/Southern_tick-associated_rash_illness" title="Southern tick-associated rash illness">Southern tick-associated rash illness</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Infestations</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tick_infestation" title="Tick infestation">Tick infestation</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Species and bites</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Amblyomma" title="Amblyomma">Amblyomma</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amblyomma_americanum" title="Amblyomma americanum">Amblyomma americanum</a></li> <li><a href="/wiki/Amblyomma_cajennense" title="Amblyomma cajennense">Amblyomma cajennense</a></li> <li><a href="/wiki/Amblyomma_triguttatum" title="Amblyomma triguttatum">Amblyomma triguttatum</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Dermacentor" title="Dermacentor">Dermacentor</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dermacentor_andersoni" title="Dermacentor andersoni">Dermacentor andersoni</a></li> <li><a href="/wiki/Dermacentor_variabilis" title="Dermacentor variabilis">Dermacentor variabilis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ixodes" title="Ixodes">Ixodes</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ixodes_cornuatus" title="Ixodes cornuatus">Ixodes cornuatus</a></li> <li><a href="/wiki/Ixodes_holocyclus" title="Ixodes holocyclus">Ixodes holocyclus</a></li> <li><a href="/wiki/Ixodes_pacificus" title="Ixodes pacificus">Ixodes pacificus</a></li> <li><a href="/wiki/Ixodes_ricinus" title="Ixodes ricinus">Ixodes ricinus</a></li> <li><a href="/wiki/Ixodes_scapularis" title="Ixodes scapularis">Ixodes scapularis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ornithodoros" title="Ornithodoros">Ornithodoros</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ornithodoros_gurneyi" title="Ornithodoros gurneyi">Ornithodoros gurneyi</a></li> <li><a href="/wiki/Ornithodoros_hermsi" title="Ornithodoros hermsi">Ornithodoros hermsi</a></li> <li><a href="/wiki/Ornithodoros_moubata" title="Ornithodoros moubata">Ornithodoros moubata</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Rhipicephalus_sanguineus" title="Rhipicephalus sanguineus">Rhipicephalus sanguineus</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Bacterial_diseases_due_to_gram_negative_non-proteobacteria_(BV4)" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Gram-negative_non-proteobacterial_diseases" title="Template:Gram-negative non-proteobacterial diseases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Gram-negative_non-proteobacterial_diseases" title="Template talk:Gram-negative non-proteobacterial diseases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Gram-negative_non-proteobacterial_diseases" title="Special:EditPage/Template:Gram-negative non-proteobacterial diseases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Bacterial_diseases_due_to_gram_negative_non-proteobacteria_(BV4)" style="font-size:114%;margin:0 4em"><a href="/wiki/Pathogenic_bacteria" title="Pathogenic bacteria">Bacterial diseases</a> due to <a href="/wiki/Gram-negative_bacteria" title="Gram-negative bacteria">gram negative</a> non-<a href="/wiki/Pseudomonadota" title="Pseudomonadota">proteobacteria</a> (<a href="/wiki/Bergey%27s_Manual_of_Systematic_Bacteriology" title="Bergey's Manual of Systematic Bacteriology">BV4</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Spirochaetota" class="mw-redirect" title="Spirochaetota">Spirochaetota</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Spirochaetaceae" title="Spirochaetaceae">Spirochaetaceae</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Treponema" title="Treponema">Treponema</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Treponema_pallidum" title="Treponema pallidum">Treponema pallidum</a> <ul><li><a href="/wiki/Syphilis" title="Syphilis">Syphilis</a>/<a href="/wiki/Nonvenereal_endemic_syphilis" title="Nonvenereal endemic syphilis">bejel</a></li> <li><a href="/wiki/Yaws" title="Yaws">Yaws</a></li></ul></li> <li><a href="/wiki/Treponema_carateum" title="Treponema carateum">Treponema carateum</a> (<a href="/wiki/Pinta_(disease)" title="Pinta (disease)">Pinta</a>)</li> <li><a href="/wiki/Treponema_denticola" title="Treponema denticola">Treponema denticola</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Borrelia" title="Borrelia">Borrelia</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Borrelia_burgdorferi" title="Borrelia burgdorferi">Borrelia burgdorferi</a>/<a href="/wiki/Borrelia_afzelii" title="Borrelia afzelii">Borrelia afzelii</a> <ul><li><a class="mw-selflink selflink">Lyme disease</a></li> <li><a href="/wiki/Erythema_migrans" title="Erythema migrans">Erythema migrans</a></li> <li><a href="/wiki/Neuroborreliosis" title="Neuroborreliosis">Neuroborreliosis</a></li></ul></li></ul> <ul><li><a href="/wiki/Borrelia_recurrentis" title="Borrelia recurrentis">Borrelia recurrentis</a> (<a href="/wiki/Relapsing_fever#Louse-borne_relapsing_fever" title="Relapsing fever">Louse borne relapsing fever</a>)</li> <li><a href="/wiki/Borrelia_hermsii" title="Borrelia hermsii">Borrelia hermsii</a>/<a href="/wiki/Borrelia_duttoni" title="Borrelia duttoni">Borrelia duttoni</a>/<a href="/wiki/Borrelia_parkeri" title="Borrelia parkeri">Borrelia parkeri</a> (<a href="/wiki/Relapsing_fever#Tick-borne_relapsing_fever" title="Relapsing fever">Tick borne relapsing fever</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Leptospiraceae" title="Leptospiraceae">Leptospiraceae</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Leptospira" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Leptospira" title="Leptospira">Leptospira</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leptospira_interrogans" title="Leptospira interrogans">Leptospira interrogans</a> (<a href="/wiki/Leptospirosis" title="Leptospirosis">Leptospirosis</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Chlamydiota" title="Chlamydiota">Chlamydiota</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Chlamydia" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Chlamydia_(genus)" title="Chlamydia (genus)">Chlamydia</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chlamydia_psittaci" title="Chlamydia psittaci">Chlamydia psittaci</a> (<a href="/wiki/Psittacosis" title="Psittacosis">Psittacosis</a>)</li> <li><a href="/wiki/Chlamydia_pneumoniae" title="Chlamydia pneumoniae">Chlamydia pneumoniae</a></li></ul> <ul><li><a href="/wiki/Chlamydia_trachomatis" title="Chlamydia trachomatis">Chlamydia trachomatis</a> <ul><li><a href="/wiki/Chlamydia" title="Chlamydia">Chlamydia</a></li> <li><a href="/wiki/Lymphogranuloma_venereum" title="Lymphogranuloma venereum">Lymphogranuloma venereum</a></li> <li><a href="/wiki/Trachoma" title="Trachoma">Trachoma</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Bacteroidota" title="Bacteroidota">Bacteroidota</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bacteroides_fragilis" title="Bacteroides fragilis">Bacteroides fragilis</a></li> <li><a href="/wiki/Tannerella_forsythia" title="Tannerella forsythia">Tannerella forsythia</a></li> <li><a href="/wiki/Capnocytophaga_canimorsus" title="Capnocytophaga canimorsus">Capnocytophaga canimorsus</a></li> <li><a href="/wiki/Porphyromonas_gingivalis" title="Porphyromonas gingivalis">Porphyromonas gingivalis</a></li> <li><a href="/wiki/Prevotella_intermedia" title="Prevotella intermedia">Prevotella intermedia</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fusobacteriota" title="Fusobacteriota">Fusobacteriota</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fusobacterium_necrophorum" title="Fusobacterium necrophorum">Fusobacterium necrophorum</a> (<a href="/wiki/Lemierre%27s_syndrome" title="Lemierre's syndrome">Lemierre's syndrome</a>)</li> <li><a href="/wiki/Fusobacterium_nucleatum" title="Fusobacterium nucleatum">Fusobacterium nucleatum</a></li> <li><a href="/wiki/Fusobacterium_polymorphum" title="Fusobacterium polymorphum">Fusobacterium polymorphum</a></li></ul> <ul><li><a href="/wiki/Streptobacillus_moniliformis" title="Streptobacillus moniliformis">Streptobacillus moniliformis</a> (<a href="/wiki/Rat-bite_fever" title="Rat-bite fever">Rat-bite fever</a>/<a href="/wiki/Haverhill_fever" title="Haverhill fever">Haverhill fever</a>)</li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Bacterial_skin_disease" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Bacterial_cutaneous_infections" title="Template:Bacterial cutaneous infections"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Bacterial_cutaneous_infections" title="Template talk:Bacterial cutaneous infections"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Bacterial_cutaneous_infections" title="Special:EditPage/Template:Bacterial cutaneous infections"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Bacterial_skin_disease" style="font-size:114%;margin:0 4em"><a href="/wiki/Bacterial_skin_disease" class="mw-redirect" title="Bacterial skin disease">Bacterial skin disease</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pathogenic_bacteria" title="Pathogenic bacteria">Gram +ve</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Bacillota" title="Bacillota">Bacillota</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Staphylococcal_infection" title="Staphylococcal infection">Staphylococcus</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Staphylococcal_scalded_skin_syndrome" title="Staphylococcal scalded skin syndrome">Staphylococcal scalded skin syndrome</a></li> <li><a href="/wiki/Impetigo" title="Impetigo">Impetigo</a></li> <li><a href="/wiki/Toxic_shock_syndrome" title="Toxic shock syndrome">Toxic shock syndrome</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Streptococcus" title="Streptococcus">Streptococcus</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Impetigo" title="Impetigo">Impetigo</a></li> <li><a href="/wiki/Cutaneous_group_B_streptococcal_infection" title="Cutaneous group B streptococcal infection">Cutaneous group B streptococcal infection</a></li> <li><a href="/wiki/Streptococcal_intertrigo" title="Streptococcal intertrigo">Streptococcal intertrigo</a></li> <li><a href="/wiki/Cutaneous_Streptococcus_iniae_infection" title="Cutaneous Streptococcus iniae infection">Cutaneous Streptococcus iniae infection</a></li> <li><a href="/wiki/Erysipelas" title="Erysipelas">Erysipelas</a> / <a href="/wiki/Chronic_recurrent_erysipelas" class="mw-redirect" title="Chronic recurrent erysipelas">Chronic recurrent erysipelas</a></li> <li><a href="/wiki/Scarlet_fever" title="Scarlet fever">Scarlet fever</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Corynebacterium" title="Corynebacterium">Corynebacterium</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Erythrasma" title="Erythrasma">Erythrasma</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Clostridium" title="Clostridium">Clostridium</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Gas_gangrene" title="Gas gangrene">Gas gangrene</a></li> <li><a href="/wiki/Dermatitis_gangrenosa" title="Dermatitis gangrenosa">Dermatitis gangrenosa</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Listeriosis" title="Listeriosis">Listeriosis</a></li> <li><a href="/wiki/Erysipeloid_of_Rosenbach" class="mw-redirect" title="Erysipeloid of Rosenbach">Erysipeloid of Rosenbach</a></li> <li><a href="/wiki/Mycoplasma" title="Mycoplasma">Mycoplasma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Actinomycetota" title="Actinomycetota">Actinomycetota</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Mycobacterium- related</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aquarium_granuloma" title="Aquarium granuloma">Aquarium granuloma</a></li> <li><a href="/wiki/Borderline_lepromatous_leprosy" title="Borderline lepromatous leprosy">Borderline lepromatous leprosy</a></li> <li><a href="/wiki/Borderline_leprosy" title="Borderline leprosy">Borderline leprosy</a></li> <li><a href="/wiki/Borderline_tuberculoid_leprosy" title="Borderline tuberculoid leprosy">Borderline tuberculoid leprosy</a></li> <li><a href="/wiki/Buruli_ulcer" title="Buruli ulcer">Buruli ulcer</a></li> <li><a href="/wiki/Erythema_induratum" title="Erythema induratum">Erythema induratum</a></li> <li><a href="/wiki/Histoid_leprosy" title="Histoid leprosy">Histoid leprosy</a></li> <li><a href="/wiki/Lepromatous_leprosy" title="Lepromatous leprosy">Lepromatous leprosy</a></li> <li><a href="/wiki/Leprosy" title="Leprosy">Leprosy</a></li> <li><a href="/wiki/Lichen_scrofulosorum" title="Lichen scrofulosorum">Lichen scrofulosorum</a></li> <li><a href="/wiki/Lupus_vulgaris" title="Lupus vulgaris">Lupus vulgaris</a></li> <li><a href="/wiki/Miliary_tuberculosis" title="Miliary tuberculosis">Miliary tuberculosis</a></li> <li><a href="/wiki/Mycobacterium_avium-intracellulare_complex_infection" class="mw-redirect" title="Mycobacterium avium-intracellulare complex infection">Mycobacterium avium–intracellulare complex infection</a></li> <li><a href="/wiki/Mycobacterium_haemophilum_infection" class="mw-redirect" title="Mycobacterium haemophilum infection">Mycobacterium haemophilum infection</a></li> <li><a href="/wiki/Mycobacterium_kansasii_infection" class="mw-redirect" title="Mycobacterium kansasii infection">Mycobacterium kansasii infection</a></li> <li><a href="/wiki/Papulonecrotic_tuberculid" title="Papulonecrotic tuberculid">Papulonecrotic tuberculid</a></li> <li><a href="/wiki/Primary_inoculation_tuberculosis" title="Primary inoculation tuberculosis">Primary inoculation tuberculosis</a></li> <li><a href="/wiki/Rapid_growing_mycobacterium_infection" class="mw-redirect" title="Rapid growing mycobacterium infection">Rapid growing mycobacterium infection</a></li> <li><a href="/wiki/Scrofuloderma" title="Scrofuloderma">Scrofuloderma</a></li> <li><a href="/wiki/Tuberculosis_cutis_orificialis" title="Tuberculosis cutis orificialis">Tuberculosis cutis orificialis</a></li> <li><a href="/wiki/Tuberculosis_verrucosa_cutis" title="Tuberculosis verrucosa cutis">Tuberculosis verrucosa cutis</a></li> <li><a href="/wiki/Tuberculous_cellulitis" title="Tuberculous cellulitis">Tuberculous cellulitis</a></li> <li><a href="/wiki/Tuberculous_gumma" title="Tuberculous gumma">Tuberculous gumma</a></li> <li><a href="/wiki/Tuberculoid_leprosy" title="Tuberculoid leprosy">Tuberculoid leprosy</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cutaneous_actinomycosis" title="Cutaneous actinomycosis">Cutaneous actinomycosis</a></li> <li><a href="/wiki/Nocardiosis" title="Nocardiosis">Nocardiosis</a></li> <li><a href="/wiki/Cutaneous_diphtheria_infection" title="Cutaneous diphtheria infection">Cutaneous diphtheria infection</a></li> <li><a href="/wiki/Arcanobacterium_haemolyticum_infection" title="Arcanobacterium haemolyticum infection">Arcanobacterium haemolyticum infection</a></li> <li><a href="/wiki/Group_JK_corynebacterium_sepsis" title="Group JK corynebacterium sepsis">Group JK corynebacterium sepsis</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Gram-negative_bacterial_infection" class="mw-redirect" title="Gram-negative bacterial infection">Gram -ve</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pseudomonadota" title="Pseudomonadota">Pseudomonadota</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Alpha</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Endemic_typhus" class="mw-redirect" title="Endemic typhus">Endemic typhus</a></li> <li><a href="/wiki/Epidemic_typhus" title="Epidemic typhus">Epidemic typhus</a></li> <li><a href="/wiki/Scrub_typhus" title="Scrub typhus">Scrub typhus</a></li> <li><a href="/wiki/North_Asian_tick_typhus" title="North Asian tick typhus">North Asian tick typhus</a></li> <li><a href="/wiki/Queensland_tick_typhus" title="Queensland tick typhus">Queensland tick typhus</a></li> <li><a href="/wiki/Flying_squirrel_typhus" title="Flying squirrel typhus">Flying squirrel typhus</a></li> <li><a href="/wiki/Trench_fever" title="Trench fever">Trench fever</a></li> <li><a href="/wiki/Bacillary_angiomatosis" title="Bacillary angiomatosis">Bacillary angiomatosis</a></li> <li><a href="/wiki/African_tick_bite_fever" title="African tick bite fever">African tick bite fever</a></li> <li><a href="/wiki/American_tick_bite_fever" class="mw-redirect" title="American tick bite fever">American tick bite fever</a></li> <li><a href="/wiki/Rickettsia_aeschlimannii_infection" title="Rickettsia aeschlimannii infection">Rickettsia aeschlimannii infection</a></li> <li><a href="/wiki/Rickettsialpox" title="Rickettsialpox">Rickettsialpox</a></li> <li><a href="/wiki/Rocky_Mountain_spotted_fever" title="Rocky Mountain spotted fever">Rocky Mountain spotted fever</a></li> <li><a href="/wiki/Human_granulocytotropic_anaplasmosis" class="mw-redirect" title="Human granulocytotropic anaplasmosis">Human granulocytotropic anaplasmosis</a></li> <li><a href="/wiki/Human_monocytotropic_ehrlichiosis" title="Human monocytotropic ehrlichiosis">Human monocytotropic ehrlichiosis</a></li> <li><a href="/wiki/Flea-borne_spotted_fever" title="Flea-borne spotted fever">Flea-borne spotted fever</a></li> <li><a href="/wiki/Japanese_spotted_fever" title="Japanese spotted fever">Japanese spotted fever</a></li> <li><a href="/wiki/Mediterranean_spotted_fever" class="mw-redirect" title="Mediterranean spotted fever">Mediterranean spotted fever</a></li> <li><a href="/wiki/Flinders_Island_spotted_fever" title="Flinders Island spotted fever">Flinders Island spotted fever</a></li> <li><a href="/wiki/Verruga_peruana" class="mw-redirect" title="Verruga peruana">Verruga peruana</a></li> <li><a href="/wiki/Brill%E2%80%93Zinsser_disease" title="Brill–Zinsser disease">Brill–Zinsser disease</a></li> <li><a href="/wiki/Brucellosis" title="Brucellosis">Brucellosis</a></li> <li><a href="/wiki/Cat-scratch_disease" title="Cat-scratch disease">Cat-scratch disease</a></li> <li><a href="/wiki/Oroya_fever" class="mw-redirect" title="Oroya fever">Oroya fever</a></li> <li><a href="/wiki/Ehrlichiosis_ewingii_infection" title="Ehrlichiosis ewingii infection">Ehrlichiosis ewingii infection</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Beta</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Gonococcemia" title="Gonococcemia">Gonococcemia</a>/<a href="/wiki/Gonorrhea" title="Gonorrhea">Gonorrhea</a>/<a href="/wiki/Primary_gonococcal_dermatitis" title="Primary gonococcal dermatitis">Primary gonococcal dermatitis</a></li> <li><a href="/wiki/Melioidosis" title="Melioidosis">Melioidosis</a></li> <li><a href="/wiki/Cutaneous_Pasteurella_hemolytica_infection" title="Cutaneous Pasteurella hemolytica infection">Cutaneous Pasteurella hemolytica infection</a></li> <li><a href="/wiki/Meningococcemia" class="mw-redirect" title="Meningococcemia">Meningococcemia</a></li> <li><a href="/wiki/Glanders" title="Glanders">Glanders</a></li> <li><a href="/wiki/Chromobacteriosis_infection" title="Chromobacteriosis infection">Chromobacteriosis infection</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Gamma</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pasteurellosis" title="Pasteurellosis">Pasteurellosis</a></li> <li><a href="/wiki/Tularemia" title="Tularemia">Tularemia</a></li> <li><a href="/wiki/Vibrio_vulnificus" title="Vibrio vulnificus">Vibrio vulnificus</a></li> <li><a href="/wiki/Rhinoscleroma" title="Rhinoscleroma">Rhinoscleroma</a></li> <li><a href="/wiki/Haemophilus_influenzae_cellulitis" title="Haemophilus influenzae cellulitis">Haemophilus influenzae cellulitis</a></li> <li><a href="/wiki/Pseudomonal_pyoderma" title="Pseudomonal pyoderma">Pseudomonal pyoderma</a> / <a href="/wiki/Pseudomonas_hot-foot_syndrome" title="Pseudomonas hot-foot syndrome">Pseudomonas hot-foot syndrome</a> / <a href="/wiki/Hot_tub_folliculitis" title="Hot tub folliculitis">Hot tub folliculitis</a> / <a href="/wiki/Ecthyma_gangrenosum" title="Ecthyma gangrenosum">Ecthyma gangrenosum</a> / <a href="/wiki/Green_nail_syndrome" title="Green nail syndrome">Green nail syndrome</a> </li> <li><a href="/wiki/Q_fever" title="Q fever">Q fever</a></li> <li><a href="/wiki/Salmonellosis" title="Salmonellosis">Salmonellosis</a></li> <li><a href="/wiki/Shigellosis" title="Shigellosis">Shigellosis</a></li> <li><a href="/wiki/Plague_(disease)" title="Plague (disease)">Plague</a></li> <li><a href="/wiki/Granuloma_inguinale" title="Granuloma inguinale">Granuloma inguinale</a></li> <li><a href="/wiki/Chancroid" title="Chancroid">Chancroid</a></li> <li><a href="/wiki/Aeromonas_infection" title="Aeromonas infection">Aeromonas infection</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Campylobacterota" title="Campylobacterota">Campylobacterota</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Helicobacter_cellulitis" title="Helicobacter cellulitis">Helicobacter cellulitis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Syphilid" title="Syphilid">Syphilid</a></li> <li><a href="/wiki/Syphilis" title="Syphilis">Syphilis</a></li> <li><a href="/wiki/Chancre" title="Chancre">Chancre</a></li> <li><a href="/wiki/Yaws" title="Yaws">Yaws</a></li> <li><a href="/wiki/Pinta_(disease)" title="Pinta (disease)">Pinta</a></li> <li><a href="/wiki/Bejel" class="mw-redirect" title="Bejel">Bejel</a></li> <li><a href="/wiki/Chlamydia_infection" class="mw-redirect" title="Chlamydia infection">Chlamydia infection</a></li> <li><a href="/wiki/Leptospirosis" title="Leptospirosis">Leptospirosis</a></li> <li><a href="/wiki/Rat-bite_fever" title="Rat-bite fever">Rat-bite fever</a></li> <li><a class="mw-selflink selflink">Lyme disease</a></li> <li><a href="/wiki/Lymphogranuloma_venereum" title="Lymphogranuloma venereum">Lymphogranuloma venereum</a></li> <li><a href="/wiki/Gram-negative_folliculitis" title="Gram-negative folliculitis">Gram-negative folliculitis</a></li> <li><a href="/wiki/Gram-negative_toe_web_infection" title="Gram-negative toe web infection">Gram-negative toe web infection</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Unspecified pathogen</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abscess" title="Abscess">Abscess</a> <ul><li><a href="/wiki/Periapical_abscess" class="mw-redirect" title="Periapical abscess">Periapical abscess</a></li></ul></li> <li><a href="/wiki/Boil" title="Boil">Boil/furuncle</a> <ul><li><a href="/wiki/Hospital_furunculosis" title="Hospital furunculosis">Hospital furunculosis</a></li></ul></li> <li><a href="/wiki/Carbuncle" title="Carbuncle">Carbuncle</a></li> <li><a href="/wiki/Cellulitis" title="Cellulitis">Cellulitis</a> <ul><li><a href="/wiki/Paronychia" title="Paronychia">Paronychia</a> / <a href="/wiki/Pyogenic_paronychia" class="mw-redirect" title="Pyogenic paronychia">Pyogenic paronychia</a></li> <li><a href="/wiki/Perianal_cellulitis" title="Perianal cellulitis">Perianal cellulitis</a></li></ul></li> <li><a href="/wiki/Lymphadenopathy" title="Lymphadenopathy">Acute lymphadenitis</a></li> <li><a href="/wiki/Pilonidal_cyst" class="mw-redirect" title="Pilonidal cyst">Pilonidal cyst</a></li> <li><a href="/wiki/Pyoderma" title="Pyoderma">Pyoderma</a></li></ul> <ul><li><a href="/wiki/Folliculitis" title="Folliculitis">Folliculitis</a> <ul><li><a href="/wiki/Superficial_pustular_folliculitis" title="Superficial pustular folliculitis">Superficial pustular folliculitis</a></li> <li><a href="/wiki/Sycosis_vulgaris" title="Sycosis vulgaris">Sycosis vulgaris</a></li></ul></li> <li><a href="/wiki/Pimple" title="Pimple">Pimple</a></li> <li><a href="/wiki/Ecthyma" title="Ecthyma">Ecthyma</a></li> <li><a href="/wiki/Pitted_keratolysis" title="Pitted keratolysis">Pitted keratolysis</a></li> <li><a href="/wiki/Trichomycosis_axillaris" class="mw-redirect" title="Trichomycosis axillaris">Trichomycosis axillaris</a></li> <li><a href="/wiki/Necrotizing_fasciitis" title="Necrotizing fasciitis">Necrotizing fasciitis</a></li> <li><a href="/wiki/Gangrene" title="Gangrene">Gangrene</a> <ul><li><a href="/wiki/Chronic_undermining_burrowing_ulcer" title="Chronic undermining burrowing ulcer">Chronic undermining burrowing ulcer</a></li> <li><a href="/wiki/Fournier_gangrene" title="Fournier gangrene">Fournier gangrene</a></li></ul></li> <li><a href="/wiki/Elephantiasis_nostras" title="Elephantiasis nostras">Elephantiasis nostras</a></li> <li><a href="/wiki/Blistering_distal_dactylitis" title="Blistering distal dactylitis">Blistering distal dactylitis</a></li> <li><a href="/wiki/Botryomycosis" title="Botryomycosis">Botryomycosis</a></li> <li><a href="/wiki/Malakoplakia" title="Malakoplakia">Malakoplakia</a></li> <li><a href="/wiki/Pyomyositis" title="Pyomyositis">Pyomyositis</a></li> <li><a href="/wiki/Blastomycosis-like_pyoderma" title="Blastomycosis-like pyoderma">Blastomycosis-like pyoderma</a></li> <li><a href="/wiki/Bullous_impetigo" title="Bullous impetigo">Bullous impetigo</a></li> <li><a href="/wiki/Chronic_lymphangitis" class="mw-redirect" title="Chronic lymphangitis">Chronic lymphangitis</a></li> <li><a href="/wiki/Recurrent_toxin-mediated_perineal_erythema" title="Recurrent toxin-mediated perineal erythema">Recurrent toxin-mediated perineal erythema</a></li> <li><a href="/wiki/Tick-borne_lymphadenopathy" title="Tick-borne lymphadenopathy">Tick-borne lymphadenopathy</a></li> <li><a href="/wiki/Tropical_ulcer" title="Tropical ulcer">Tropical ulcer</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"></div><div role="navigation" class="navbox" aria-labelledby="Artificial_induction_of_immunity_/_Immunization:_Vaccines,_Vaccination,_Infection,_Inoculation_(J07)" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Vaccines" title="Template:Vaccines"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Vaccines" title="Template talk:Vaccines"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Vaccines" title="Special:EditPage/Template:Vaccines"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Artificial_induction_of_immunity_/_Immunization:_Vaccines,_Vaccination,_Infection,_Inoculation_(J07)" style="font-size:114%;margin:0 4em"><a href="/wiki/Artificial_induction_of_immunity" title="Artificial induction of immunity">Artificial induction of immunity</a> / <a href="/wiki/Immunization" title="Immunization">Immunization</a>: <a href="/wiki/Vaccine" title="Vaccine">Vaccines</a>, <a href="/wiki/Vaccination" title="Vaccination">Vaccination</a>, <a href="/wiki/Infection" title="Infection">Infection</a>, <a href="/wiki/Inoculation" title="Inoculation">Inoculation</a> (<a href="/wiki/ATC_code_J07" title="ATC code J07">J07</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Development</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Immunologic_adjuvant" title="Immunologic adjuvant">Adjuvants</a></li> <li><a href="/wiki/Vaccine_ingredients" title="Vaccine ingredients">Vaccine ingredients</a> <ul><li><a href="/wiki/List_of_vaccine_excipients" title="List of vaccine excipients">list</a></li></ul></li> <li><a href="/wiki/Mathematical_modelling_of_infectious_diseases" title="Mathematical modelling of infectious diseases">Mathematical modelling</a></li> <li><a href="/wiki/Vaccine_storage" title="Vaccine storage">Storage</a></li> <li><a href="/wiki/Timeline_of_human_vaccines" title="Timeline of human vaccines">Timeline</a></li> <li><a href="/wiki/Vaccine_trial" title="Vaccine trial">Trials</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classes</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Conjugate_vaccine" title="Conjugate vaccine">Conjugate</a></li> <li><a href="/wiki/Inactivated_vaccine" title="Inactivated vaccine">Inactivated</a></li> <li>Live <ul><li><a href="/wiki/Attenuated_vaccine" title="Attenuated vaccine">Attenuated</a></li> <li><a href="/wiki/Heterologous_vaccine" title="Heterologous vaccine">Heterologous</a></li></ul></li> <li><a href="/wiki/Subunit_vaccine" title="Subunit vaccine">Subunit/component</a> / <a href="/wiki/Peptide_vaccine" title="Peptide vaccine">Peptide</a> / <a href="/wiki/Virus-like_particle" title="Virus-like particle">Virus-like particle</a> / <a href="/wiki/Synthetic_vaccine" title="Synthetic vaccine">Synthetic</a></li> <li><a href="/wiki/DNA_vaccine" title="DNA vaccine">DNA</a> / <a href="/wiki/MRNA_vaccine" title="MRNA vaccine">mRNA</a></li> <li><a href="/wiki/Therapeutic_vaccines" title="Therapeutic vaccines">Therapeutic</a></li> <li><a href="/wiki/Toxoid" title="Toxoid">Toxoid</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Administration</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Global: <ul><li><a href="/wiki/GAVI" title="GAVI">GAVI Alliance</a></li> <li><a href="/wiki/National_Immunization_Technical_Advisory_Group" title="National Immunization Technical Advisory Group">NITAG</a></li> <li><a href="/wiki/Strategic_Advisory_Group_of_Experts" title="Strategic Advisory Group of Experts">SAGE</a></li> <li><a href="/wiki/Vaccine_wastage" title="Vaccine wastage">Vaccine wastage</a></li> <li><a href="/wiki/Vaccination_policy" title="Vaccination policy">Policy</a></li> <li><a href="/wiki/Vaccination_schedule" title="Vaccination schedule">Schedule</a></li> <li><a href="/wiki/Vaccine_adverse_event" title="Vaccine adverse event">Vaccine injury</a></li></ul></li> <li>US: <ul><li><a href="/wiki/Advisory_Committee_on_Immunization_Practices" title="Advisory Committee on Immunization Practices">ACIP</a></li> <li><a href="/wiki/National_Vaccine_Injury_Compensation_Program" title="National Vaccine Injury Compensation Program">Vaccine court</a></li> <li><a href="/wiki/Vaccines_for_Children_Program" title="Vaccines for Children Program">Vaccines for Children Program</a></li> <li><a href="/wiki/Vaccine_Adverse_Event_Reporting_System" title="Vaccine Adverse Event Reporting System">VAERS</a></li> <li><a href="/wiki/Vaccine_Safety_Datalink" title="Vaccine Safety Datalink">VSD</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Vaccines</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Bacterial</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anthrax_vaccine" title="Anthrax vaccine">Anthrax</a></li> <li><a href="/wiki/Brucellosis_vaccine" title="Brucellosis vaccine">Brucellosis</a></li> <li><a href="/wiki/Cholera_vaccine" title="Cholera vaccine">Cholera</a>#</li> <li><a href="/wiki/Diphtheria_vaccine" title="Diphtheria vaccine">Diphtheria</a>#</li> <li><a href="/wiki/Hib_vaccine" title="Hib vaccine">Hib</a>#</li> <li><a href="/wiki/Leptospirosis#Prevention" title="Leptospirosis">Leptospirosis</a></li> <li><a class="mw-selflink-fragment" href="#Vaccination">Lyme disease</a>‡</li> <li><a href="/wiki/Meningococcal_vaccine" title="Meningococcal vaccine">Meningococcus</a># <ul><li><a href="/wiki/MeNZB" title="MeNZB">MeNZB</a></li> <li><a href="/wiki/NmVac4-A/C/Y/W-135" title="NmVac4-A/C/Y/W-135">NmVac4-A/C/Y/W-135</a></li></ul></li> <li><a href="/wiki/Pertussis_vaccine" title="Pertussis vaccine">Pertussis</a>#</li> <li><a href="/wiki/Plague_vaccine" title="Plague vaccine">Plague</a></li> <li><a href="/wiki/Pneumococcal_vaccine" title="Pneumococcal vaccine">Pneumococcal</a># <ul><li><a href="/wiki/Pneumococcal_conjugate_vaccine" title="Pneumococcal conjugate vaccine">PCV</a></li> <li><a href="/wiki/Pneumococcal_polysaccharide_vaccine" title="Pneumococcal polysaccharide vaccine">PPSV</a></li></ul></li> <li><a href="/wiki/Q_fever#Prevention" title="Q fever">Q fever</a></li> <li><a href="/wiki/Tetanus_vaccine" title="Tetanus vaccine">Tetanus</a>#</li> <li><a href="/wiki/Tuberculosis_vaccines" title="Tuberculosis vaccines">Tuberculosis</a> <ul><li><a href="/wiki/BCG_vaccine" title="BCG vaccine">BCG</a>#</li></ul></li> <li><a href="/wiki/Typhoid_vaccine" title="Typhoid vaccine">Typhoid</a># <ul><li><a href="/wiki/Ty21a" title="Ty21a">Ty21a</a></li> <li><a href="/wiki/Vi_capsular_polysaccharide_vaccine" title="Vi capsular polysaccharide vaccine">ViCPS</a></li></ul></li> <li><a href="/wiki/Typhus_vaccine" title="Typhus vaccine">Typhus</a></li> <li>combination: <ul><li><a href="/wiki/DPT_vaccine" title="DPT vaccine">DPT/DTwP/DTaP</a></li> <li><a href="/wiki/Tetanus_vaccine" title="Tetanus vaccine">Td/Tdap</a></li></ul></li> <li>research: <ul><li><a href="/wiki/Clostridioides_difficile_infection#Research" title="Clostridioides difficile infection">Clostridioides difficile</a></li> <li><a href="/wiki/Group_B_streptococcal_infection#Vaccine" title="Group B streptococcal infection">Group B streptococcal disease</a></li> <li><a href="/wiki/Shigellosis#Vaccine" title="Shigellosis">Shigellosis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Viral</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenovirus_vaccine" title="Adenovirus vaccine">Adenovirus</a></li> <li><a href="/wiki/Chikungunya_vaccine" title="Chikungunya vaccine">Chikungunya</a></li> <li><a href="/wiki/Ebola_vaccine" title="Ebola vaccine">Ebola</a> <ul><li><a href="/wiki/RVSV-ZEBOV_vaccine" title="RVSV-ZEBOV vaccine">rVSV-ZEBOV</a></li></ul></li> <li><a href="/wiki/Influenza_vaccine" title="Influenza vaccine">Flu</a># <ul><li><a href="/wiki/2009_swine_flu_pandemic_vaccine" title="2009 swine flu pandemic vaccine">H1N1</a> (<a href="/wiki/Pandemrix" title="Pandemrix">Pandemrix</a>)</li> <li><a href="/wiki/H5N1_vaccine" title="H5N1 vaccine">H5N1</a></li> <li><a href="/wiki/H5N8_vaccine" title="H5N8 vaccine">H5N8</a></li> <li><a href="/wiki/Live_attenuated_influenza_vaccine" title="Live attenuated influenza vaccine">LAIV</a></li></ul></li> <li><a href="/wiki/Hantavirus_vaccine" title="Hantavirus vaccine">Hantavirus</a></li> <li><a href="/wiki/Hepatitis_A_vaccine" title="Hepatitis A vaccine">Hepatitis A</a>#</li> <li><a href="/wiki/Hepatitis_B_vaccine" title="Hepatitis B vaccine">Hepatitis B</a>#</li> <li><a href="/wiki/Hepatitis_E#Vaccines" title="Hepatitis E">Hepatitis E</a></li> <li><a href="/wiki/HPV_vaccine" title="HPV vaccine">HPV</a># <ul><li><a href="/wiki/Cervarix" title="Cervarix">Cervarix</a></li> <li><a href="/wiki/Gardasil" title="Gardasil">Gardasil</a></li></ul></li> <li><a href="/wiki/Japanese_encephalitis_vaccine" title="Japanese encephalitis vaccine">Japanese encephalitis</a>#</li> <li><a href="/wiki/Measles_vaccine" title="Measles vaccine">Measles</a>#</li> <li><a href="/wiki/Mpox_vaccine" class="mw-redirect" title="Mpox vaccine">Mpox</a></li> <li><a href="/wiki/Mumps_vaccine" title="Mumps vaccine">Mumps</a>#</li> <li><a href="/wiki/Polio_vaccine" title="Polio vaccine">Polio</a># <ul><li><a href="/wiki/Polio_vaccine#Attenuated" title="Polio vaccine">Sabin</a></li> <li><a href="/wiki/Polio_vaccine#Inactivated" title="Polio vaccine">Salk</a></li></ul></li> <li><a href="/wiki/Rabies_vaccine" title="Rabies vaccine">Rabies</a>#</li> <li><a href="/wiki/Rotavirus_vaccine" title="Rotavirus vaccine">Rotavirus</a>#</li> <li><a href="/wiki/Rubella_vaccine" title="Rubella vaccine">Rubella</a>#</li> <li><a href="/wiki/COVID-19_vaccine" title="COVID-19 vaccine">SARS-CoV-2</a> <ul><li><a href="/wiki/Corbevax" title="Corbevax">Corbevax</a>†</li> <li><a href="/wiki/Covaxin" title="Covaxin">Bharat Biotech</a>†</li> <li><a href="/wiki/Convidecia" title="Convidecia">CanSino</a>†</li> <li><a href="/wiki/CoronaVac" title="CoronaVac">CoronaVac</a>†</li> <li><a href="/wiki/EpiVacCorona" title="EpiVacCorona">EpiVacCorona</a>†</li> <li><a href="/wiki/Janssen_COVID-19_vaccine" title="Janssen COVID-19 vaccine">Janssen</a></li> <li><a href="/wiki/Moderna_COVID-19_vaccine" title="Moderna COVID-19 vaccine">Moderna</a></li> <li><a href="/wiki/Novavax_COVID-19_vaccine" title="Novavax COVID-19 vaccine">Novavax</a></li> <li><a href="/wiki/Oxford%E2%80%93AstraZeneca_COVID-19_vaccine" title="Oxford–AstraZeneca COVID-19 vaccine">Oxford–AstraZeneca</a></li> <li><a href="/wiki/Pfizer%E2%80%93BioNTech_COVID-19_vaccine" title="Pfizer–BioNTech COVID-19 vaccine">Pfizer–BioNTech</a></li> <li><a href="/wiki/Sanofi%E2%80%93GSK_COVID-19_vaccine" title="Sanofi–GSK COVID-19 vaccine">Sanofi–GSK</a>†</li> <li><a href="/wiki/Sinopharm_BIBP_COVID-19_vaccine" title="Sinopharm BIBP COVID-19 vaccine">Sinopharm BIBP</a>†</li> <li><a href="/wiki/Skycovione" title="Skycovione">Skycovione</a>†</li> <li><a href="/wiki/Sputnik_V_COVID-19_vaccine" title="Sputnik V COVID-19 vaccine">Sputnik V</a>†</li> <li><a href="/wiki/Valneva_COVID-19_vaccine" title="Valneva COVID-19 vaccine">Valneva</a>†</li></ul></li> <li><a href="/wiki/Respiratory_syncytial_virus_vaccine" title="Respiratory syncytial virus vaccine">Respiratory syncytial virus (RSV)</a></li> <li><a href="/wiki/Smallpox_vaccine" title="Smallpox vaccine">Smallpox</a></li> <li><a href="/wiki/Tick-borne_encephalitis_vaccine" title="Tick-borne encephalitis vaccine">Tick-borne encephalitis</a>#</li> <li>Varicella zoster <ul><li><a href="/wiki/Varicella_vaccine" title="Varicella vaccine">Chicken pox</a>#</li> <li><a href="/wiki/Zoster_vaccine" title="Zoster vaccine">Shingles</a></li></ul></li> <li><a href="/wiki/Yellow_fever_vaccine" title="Yellow fever vaccine">Yellow fever</a>#</li> <li>combination: <ul><li><a href="/wiki/Hepatitis_A_and_B_vaccine" title="Hepatitis A and B vaccine">Hepatitis A and B</a></li> <li><a href="/wiki/MMR_vaccine" title="MMR vaccine">MMR</a></li> <li><a href="/wiki/MMRV_vaccine" title="MMRV vaccine">MMRV</a></li></ul></li> <li>research: <ul><li><a href="/wiki/Cytomegalovirus_vaccine" title="Cytomegalovirus vaccine">Cytomegalovirus</a></li> <li><a href="/wiki/Dengue_vaccine" title="Dengue vaccine">Dengue</a>#</li> <li><a href="/wiki/Epstein%E2%80%93Barr_virus_vaccine" title="Epstein–Barr virus vaccine">Epstein–Barr virus</a></li> <li><a href="/wiki/Hepatitis_C_vaccine" title="Hepatitis C vaccine">Hepatitis C</a></li> <li><a href="/wiki/Herpes_simplex_research" title="Herpes simplex research">Herpes simplex</a></li> <li><a href="/wiki/HIV_vaccine_development" title="HIV vaccine development">HIV</a></li> <li><a href="/wiki/Zika_virus_vaccine" title="Zika virus vaccine">Zika</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Protozoan</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Malaria_vaccine" title="Malaria vaccine">Malaria</a> <ul><li><a href="/wiki/RTS,S" title="RTS,S">RTS,S</a></li></ul></li> <li>research: <ul><li><a href="/wiki/Trypanosomiasis_vaccine" title="Trypanosomiasis vaccine">Trypanosomiasis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Helminthiasis" title="Helminthiasis">Helminthiasis</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>research: <ul><li><a href="/wiki/Hookworm_vaccine" title="Hookworm vaccine">Hookworm</a></li> <li><a href="/wiki/Schistosomiasis_vaccine" title="Schistosomiasis vaccine">Schistosomiasis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Androvax" title="Androvax">Androvax (androstenedione albumin)</a></li> <li><a href="/wiki/Cancer_vaccine" title="Cancer vaccine">Cancer vaccines</a> <ul><li><a href="/wiki/ALVAC-CEA_vaccine" title="ALVAC-CEA vaccine">ALVAC-CEA</a></li> <li><a href="/wiki/BCG_vaccine" title="BCG vaccine">BCG</a>#</li> <li><a href="/wiki/Hepatitis_B_vaccine" title="Hepatitis B vaccine">Hepatitis B</a>#</li> <li><a href="/wiki/HPV_vaccine" title="HPV vaccine">HPV</a># <ul><li><a href="/wiki/Cervarix" title="Cervarix">Cervarix</a></li> <li><a href="/wiki/Gardasil" title="Gardasil">Gardasil</a></li></ul></li> <li><a href="/wiki/Prostvac" title="Prostvac">Prostvac</a></li></ul></li> <li><a href="/wiki/NicVAX" title="NicVAX">NicVAX</a></li> <li><a href="/wiki/Ovandrotone_albumin" title="Ovandrotone albumin">Ovandrotone albumin (Fecundin)</a></li> <li><a href="/wiki/TA-CD" title="TA-CD">TA-CD</a></li> <li><a href="/wiki/TA-NIC" title="TA-NIC">TA-NIC</a></li> <li>combination: <ul><li><a href="/wiki/DTaP-IPV/Hib_vaccine" title="DTaP-IPV/Hib vaccine">DTaP-IPV/Hib</a></li> <li><a href="/wiki/DTaP-IPV-HepB_vaccine" title="DTaP-IPV-HepB vaccine">DTaP-IPV-HepB</a></li> <li><a href="/wiki/DTwP-HepB-Hib_vaccine" title="DTwP-HepB-Hib vaccine">DTwP-HepB-Hib</a></li> <li><a href="/wiki/Hexavalent_vaccine" title="Hexavalent vaccine">Hexavalent vaccine</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Inventors/ researchers</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Edward_Jenner" title="Edward Jenner">Edward Jenner</a></li> <li><a href="/wiki/Louis_Pasteur" title="Louis Pasteur">Louis Pasteur</a></li> <li><a href="/wiki/Hilary_Koprowski" title="Hilary Koprowski">Hilary Koprowski</a></li> <li><a href="/wiki/Jonas_Salk" title="Jonas Salk">Jonas Salk</a></li> <li><a href="/wiki/John_Franklin_Enders" title="John Franklin Enders">John Franklin Enders</a></li> <li><a href="/wiki/Maurice_Hilleman" title="Maurice Hilleman">Maurice Hilleman</a></li> <li><a href="/wiki/Stanley_Plotkin" title="Stanley Plotkin">Stanley Plotkin</a></li> <li><a href="/wiki/H._Fred_Clark" title="H. Fred Clark">H. Fred Clark</a></li> <li><a href="/wiki/Paul_Offit" title="Paul Offit">Paul Offit</a></li> <li><a href="/wiki/Katalin_Karik%C3%B3" title="Katalin Karikó">Katalin Karikó</a></li> <li><a href="/wiki/Drew_Weissman" title="Drew Weissman">Drew Weissman</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Controversy</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vaccine_hesitancy" title="Vaccine hesitancy">General</a></li> <li><a href="/wiki/MMR_vaccine_and_autism" title="MMR vaccine and autism">MMR</a> (<a href="/wiki/Lancet_MMR_autism_fraud" title="Lancet MMR autism fraud">Lancet MMR autism fraud</a>)</li> <li><a href="/wiki/National_Childhood_Vaccine_Injury_Act" title="National Childhood Vaccine Injury Act">NCVIA</a></li> <li><a href="/wiki/Pox_party" title="Pox party">Pox party</a></li> <li><a href="/wiki/Thiomersal_and_vaccines" title="Thiomersal and vaccines">Thiomersal</a></li> <li><a href="/wiki/Vaccines_and_SIDS" title="Vaccines and SIDS">Vaccines and SIDS</a></li> <li><a href="/wiki/Cedillo_v._Secretary_of_Health_and_Human_Services" title="Cedillo v. Secretary of Health and Human Services">Cedillo v. 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