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Tyrosinkinasreceptor – Wikipedia

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[o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Logga in</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Sidor för utloggade redigerare <a href="/wiki/Hj%C3%A4lp:Introduktion" aria-label="Läs mer om redigering"><span>läs mer</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:Mina_bidrag" title="En lista över redigeringar från denna IP-adress [y]" accesskey="y"><span>Bidrag</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:Min_diskussion" title="Diskussion om redigeringar från det här IP-numret [n]" accesskey="n"><span>Diskussion</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"><!-- CentralNotice --></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Webbplats"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Tyrosinkinasreceptor</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Gå till en artikel på ett annat språk. Tillgänglig på 20 språk" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-20" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">20 språk</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Receptorska_tirozin-kinaza" title="Receptorska tirozin-kinaza – bosniska" lang="bs" hreflang="bs" data-title="Receptorska tirozin-kinaza" data-language-autonym="Bosanski" data-language-local-name="bosniska" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Receptor_tirosina-cinasa" title="Receptor tirosina-cinasa – katalanska" lang="ca" hreflang="ca" data-title="Receptor tirosina-cinasa" data-language-autonym="Català" data-language-local-name="katalanska" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Tyrosinkin%C3%A1zov%C3%BD_receptor" title="Tyrosinkinázový receptor – tjeckiska" lang="cs" hreflang="cs" data-title="Tyrosinkinázový receptor" data-language-autonym="Čeština" data-language-local-name="tjeckiska" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Receptortyrosinkinase" title="Receptortyrosinkinase – danska" lang="da" hreflang="da" data-title="Receptortyrosinkinase" data-language-autonym="Dansk" data-language-local-name="danska" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Rezeptor-Tyrosinkinasen" title="Rezeptor-Tyrosinkinasen – tyska" lang="de" hreflang="de" data-title="Rezeptor-Tyrosinkinasen" data-language-autonym="Deutsch" data-language-local-name="tyska" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase – engelska" lang="en" hreflang="en" data-title="Receptor tyrosine kinase" data-language-autonym="English" data-language-local-name="engelska" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Receptor_tirosina_quinasa" title="Receptor tirosina quinasa – spanska" lang="es" hreflang="es" data-title="Receptor tirosina quinasa" data-language-autonym="Español" data-language-local-name="spanska" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%AA%DB%8C%D8%B1%D9%88%D8%B2%DB%8C%D9%86_%DA%A9%DB%8C%D9%86%D8%A7%D8%B2_%DA%AF%DB%8C%D8%B1%D9%86%D8%AF%D9%87%E2%80%8C%D8%A7%DB%8C" title="تیروزین کیناز گیرنده‌ای – persiska" lang="fa" hreflang="fa" data-title="تیروزین کیناز گیرنده‌ای" data-language-autonym="فارسی" data-language-local-name="persiska" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/R%C3%A9cepteur_%C3%A0_activit%C3%A9_tyrosine_kinase" title="Récepteur à activité tyrosine kinase – franska" lang="fr" hreflang="fr" data-title="Récepteur à activité tyrosine kinase" data-language-autonym="Français" data-language-local-name="franska" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Recettori_tirosin_chinasici" title="Recettori tirosin chinasici – italienska" lang="it" hreflang="it" data-title="Recettori tirosin chinasici" data-language-autonym="Italiano" data-language-local-name="italienska" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ka mw-list-item"><a href="https://ka.wikipedia.org/wiki/%E1%83%97%E1%83%98%E1%83%A0%E1%83%9D%E1%83%96%E1%83%98%E1%83%9C%E1%83%99%E1%83%98%E1%83%9C%E1%83%90%E1%83%96%E1%83%A3%E1%83%9A%E1%83%98_%E1%83%A0%E1%83%94%E1%83%AA%E1%83%94%E1%83%9E%E1%83%A2%E1%83%9D%E1%83%A0%E1%83%94%E1%83%91%E1%83%98" title="თიროზინკინაზული რეცეპტორები – georgiska" lang="ka" hreflang="ka" data-title="თიროზინკინაზული რეცეპტორები" data-language-autonym="ქართული" data-language-local-name="georgiska" class="interlanguage-link-target"><span>ქართული</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Tiroz%C4%ABnkin%C4%81zes_receptori" title="Tirozīnkināzes receptori – lettiska" lang="lv" hreflang="lv" data-title="Tirozīnkināzes receptori" data-language-autonym="Latviešu" data-language-local-name="lettiska" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Receptor-tyrosinekinase" title="Receptor-tyrosinekinase – nederländska" lang="nl" hreflang="nl" data-title="Receptor-tyrosinekinase" data-language-autonym="Nederlands" data-language-local-name="nederländska" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E5%8F%97%E5%AE%B9%E4%BD%93%E5%9E%8B%E3%83%81%E3%83%AD%E3%82%B7%E3%83%B3%E3%82%AD%E3%83%8A%E3%83%BC%E3%82%BC" title="受容体型チロシンキナーゼ – japanska" lang="ja" hreflang="ja" data-title="受容体型チロシンキナーゼ" data-language-autonym="日本語" data-language-local-name="japanska" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A0%D0%B5%D1%86%D0%B5%D0%BF%D1%82%D0%BE%D1%80%D0%BD%D1%8B%D0%B5_%D1%82%D0%B8%D1%80%D0%BE%D0%B7%D0%B8%D0%BD%D0%BA%D0%B8%D0%BD%D0%B0%D0%B7%D1%8B" title="Рецепторные тирозинкиназы – ryska" lang="ru" hreflang="ru" data-title="Рецепторные тирозинкиназы" data-language-autonym="Русский" data-language-local-name="ryska" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Receptor_s_tyroz%C3%ADnkin%C3%A1zovou_aktivitou" title="Receptor s tyrozínkinázovou aktivitou – slovakiska" lang="sk" hreflang="sk" data-title="Receptor s tyrozínkinázovou aktivitou" data-language-autonym="Slovenčina" data-language-local-name="slovakiska" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Receptor_tirozinska_kinaza" title="Receptor tirozinska kinaza – serbiska" lang="sr" hreflang="sr" data-title="Receptor tirozinska kinaza" data-language-autonym="Српски / srpski" data-language-local-name="serbiska" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Receptorska_tirozinska_kinaza" title="Receptorska tirozinska kinaza – serbokroatiska" lang="sh" hreflang="sh" data-title="Receptorska tirozinska kinaza" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbokroatiska" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Tyrosiinikinaasireseptorit" title="Tyrosiinikinaasireseptorit – finska" lang="fi" hreflang="fi" data-title="Tyrosiinikinaasireseptorit" data-language-autonym="Suomi" data-language-local-name="finska" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%8F%97%E9%AB%94%E9%85%AA%E6%B0%A8%E9%85%B8%E6%BF%80%E9%85%B6" title="受體酪氨酸激酶 – kinesiska" lang="zh" hreflang="zh" data-title="受體酪氨酸激酶" data-language-autonym="中文" data-language-local-name="kinesiska" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q420511#sitelinks-wikipedia" title="Redigera interwikilänkar" class="wbc-editpage">Redigera länkar</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namnrymder"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Tyrosinkinasreceptor" title="Visa innehållssidan [c]" accesskey="c"><span>Artikel</span></a></li><li id="ca-talk" class="new vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Diskussion:Tyrosinkinasreceptor&amp;action=edit&amp;redlink=1" rel="discussion" class="new" title="Diskussion om innehållssidan [inte skriven än] [t]" accesskey="t"><span>Diskussion</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > 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href="/w/index.php?title=Special:DownloadAsPdf&amp;page=Tyrosinkinasreceptor&amp;action=show-download-screen"><span>Ladda ned som PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Tyrosinkinasreceptor&amp;printable=yes" title="Utskriftsvänlig version av den här sidan [p]" accesskey="p"><span>Utskriftsvänlig version</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> På andra projekt </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:Receptor_protein-tyrosine_kinases" hreflang="en"><span>Commons</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q420511" title="Länk till anslutet databasobjekt [g]" accesskey="g"><span>Wikidata-objekt</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Sidverktyg"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Utseende"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Utseende</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">flytta till sidofältet</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">dölj</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Från Wikipedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sv" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r51224235">.mw-parser-output table.ambox{margin:0 10%;border-collapse:collapse;background:#fbfbfb;border:1px solid #aaa;border-left:10px solid #608ec2}.mw-parser-output table.ambox th.ambox-text,.mw-parser-output table.ambox td.ambox-text{padding:.25em .5em;width:100%}.mw-parser-output table.ambox td.ambox-image{padding:2px 0 2px .5em;text-align:center;vertical-align:middle}.mw-parser-output table.ambox td.ambox-imageright{padding:2px 4px 2px 0;text-align:center;vertical-align:middle}.mw-parser-output table.ambox-notice{border-left:10px solid #608ec2}.mw-parser-output table.ambox-delete,.mw-parser-output table.ambox-serious{border-left:10px solid #b22222}.mw-parser-output table.ambox-content{border-left:10px solid #f28500}.mw-parser-output table.ambox-style{border-left:10px solid #f4c430}.mw-parser-output table.ambox-merge{border-left:10px solid #9932cc}.mw-parser-output table.ambox-protection{border-left:10px solid #bba}.mw-parser-output .ambox+link+.ambox{border-top-width:0}.mw-parser-output .messagebox{border:1px solid #aaaaaa;background-color:#f8f9fa;width:80%;margin:0 auto 1em auto;padding:.2em}.mw-parser-output .messagebox.merge{border:1px solid #c0b8cc;background-color:#f0e5ff;text-align:center}.mw-parser-output .messagebox.cleanup{border:1px solid #9f9fff;background-color:#efefff;text-align:center}.mw-parser-output .messagebox.standard-talk{border:1px solid #c0c090;background-color:#f8eaba}.mw-parser-output .messagebox.nested-talk{border:1px solid #c0c090;background-color:#f8eaba;width:100%;margin:2px 4px}</style><table class="metadata ambox ambox-content" style=""> <tbody><tr> <td class="ambox-image"> <div style="width:52px;"><span typeof="mw:File"><a href="/wiki/Fil:Question_book-4.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Question_book-4.svg/40px-Question_book-4.svg.png" decoding="async" width="40" height="31" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Question_book-4.svg/60px-Question_book-4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/64/Question_book-4.svg/80px-Question_book-4.svg.png 2x" data-file-width="262" data-file-height="204" /></a></span></div></td> <td class="ambox-text">Den här artikeln <b>behöver <a href="/wiki/Wikipedia:K%C3%A4llh%C3%A4nvisningar" title="Wikipedia:Källhänvisningar">källhänvisningar</a> för att kunna <a href="/wiki/Wikipedia:Verifierbarhet" title="Wikipedia:Verifierbarhet">verifieras</a>.</b> <small>(2016-10)</small> <br /><small>Åtgärda genom att lägga till pålitliga källor (<a href="/wiki/Wikipedia:Introduktion_till_k%C3%A4llh%C3%A4nvisningar" title="Wikipedia:Introduktion till källhänvisningar">gärna som fotnoter</a>). Uppgifter utan källhänvisning kan <a href="/wiki/Mall:K%C3%A4lla_beh%C3%B6vs" title="Mall:Källa behövs">ifrågasättas</a> och tas bort utan att det behöver diskuteras på <a href="/w/index.php?title=Diskussion:Tyrosinkinasreceptor&amp;action=edit&amp;redlink=1" class="new" title="Diskussion:Tyrosinkinasreceptor [inte skriven än]">diskussionssidan</a>.</small></td> </tr> </tbody></table> <p><b>Tyrosinkinasreceptorer</b> är en grupp av <a href="/wiki/Receptorer" class="mw-redirect" title="Receptorer">receptorer</a> som uttrycks på <a href="/wiki/Cellmembran" title="Cellmembran">cellmembranet</a> av olika celler. De har en transmembran domän bestående av en <a href="/wiki/Alfa-helix" class="mw-redirect" title="Alfa-helix">alfa-helix</a>, och aktiveras av att binda ligander vilket gör att två receptorer kan dimerisera. Detta gör så att deras intracellulära domäner kan fosforylera varandras "läppar". Genom den här fosforyleringen så kan läppen röra sig bort från den enzymatiska delen av kinaset vilket ökar aktiviteten för kinaset genom att affiniteten för ATP ökar så att kinaset kan fosforylera alla tyrosiner. Fosfotyrosinen utgör startpunkt för olika proteiner så att <a href="/w/index.php?title=Signaltransduktionskedja&amp;action=edit&amp;redlink=1" class="new" title="Signaltransduktionskedja [inte skriven än]">signaltransduktionskedjor</a> bildas nedströms. </p><p>Tyrosinkinasreceptorer kan aktivera följande signaltransduktionsvägar: </p> <ul><li><a href="/w/index.php?title=Ras/MAPKinas-signalv%C3%A4gen&amp;action=edit&amp;redlink=1" class="new" title="Ras/MAPKinas-signalvägen [inte skriven än]">Ras/MAPKinas-signalvägen</a></li> <li><a href="/w/index.php?title=PI3K/PKB-signalv%C3%A4gen&amp;action=edit&amp;redlink=1" class="new" title="PI3K/PKB-signalvägen [inte skriven än]">PI3K/PKB-signalvägen</a></li> <li><a href="/w/index.php?title=Fosfolipas_C-IP3/DAG-PKC-signalv%C3%A4gen&amp;action=edit&amp;redlink=1" class="new" title="Fosfolipas C-IP3/DAG-PKC-signalvägen [inte skriven än]">Fosfolipas C-IP3/DAG-PKC-signalvägen</a></li></ul> <p>Detta är i stort sett samma som <a href="/wiki/Cytokinreceptor" title="Cytokinreceptor">cytokinreceptorer</a> kan aktivera, bortsett från att tyrosinkinasreceptorer inte kan aktivera <a href="/wiki/JAK-STAT-signaltransduktionsv%C3%A4g" class="mw-redirect" title="JAK-STAT-signaltransduktionsväg">JAK-STAT-signaltransduktionsvägen</a>. </p> <!-- NewPP limit report Parsed by mw‐api‐int.codfw.main‐7858d788f6‐5kc68 Cached time: 20241102134413 Cache expiry: 2592000 Reduced expiry: false Complications: [] CPU time usage: 0.044 seconds Real time usage: 0.057 seconds Preprocessor visited node count: 158/1000000 Post‐expand include size: 2994/2097152 bytes Template argument size: 666/2097152 bytes Highest expansion depth: 10/100 Expensive parser function count: 0/500 Unstrip recursion depth: 0/20 Unstrip post‐expand size: 1632/5000000 bytes Lua time usage: 0.003/10.000 seconds Lua memory usage: 619172/52428800 bytes Number of Wikibase entities loaded: 0/400 --> <!-- Transclusion expansion time report (%,ms,calls,template) 100.00% 42.835 1 Mall:Källor 100.00% 42.835 1 -total 91.03% 38.992 1 Mall:Källor_metamall 84.92% 36.375 1 Mall:Ambox 4.19% 1.795 1 Mall:Omsubst --> <!-- Saved in parser cache with key svwiki:pcache:idhash:1554453-0!canonical and timestamp 20241102134413 and revision id 37814638. 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