Polymorph prediction through observed structural isomorphism leading to a new crystalline form of cannabidiol

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Sci.; citation_volume=13; citation_pages=1288-1297;citation_publication_date=2022; " /> <meta name="citation_fulltext_world_readable" content="" /> <meta content=" Cannabidiol (CBD) is a naturally occurring phytocannabinoid, approved for use in the US and other countries for the treatment of seizures associated with Dravet syndrome, Lennox–Gastaut syndrome and tuberous sclerosis complex, and is commonly isolated and used in its well-known stable crystalline form (form 1). We present a study of the crystal structures of an homologous series of CBD analogues, containing variations in the alkyl sidechain at C-5′, which shows that CBD form 1 is an unusual structural outlier. CBD C-5′ homologues display homologous isomorphism, existing as isomorphic variants in the solid state, whereas CBD form 1 shows notably different crystal packing, suggesting the potential existence of a previously uncharacterized isomorphic CBD polymorph. This predicted isomorphic CBD polymorph (form 2) was subsequently discovered through the use of high throughput crystallisation techniques (ENaCt) in combination with CBD homologue seeding, with single crystal X-ray diffraction analysis demonstrating its fit within the larger isomorphic series. This work represents the first example of directed polymorph discovery using high throughput ENaCt techniques. 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CCDC 2234293–2234299. For ESI and crystallographic data in CIF or other electronic format see DOI: https://doi.org/10.1039/d3ce00041a">†</a> </h2> <div class="fixpadv--m crossmark-button"> <button type="button" data-target="crossmark"><img width="150" height="32" src="https://crossmark-cdn.crossref.org/widget/v2.0/logos/CROSSMARK_Color_horizontal.svg" alt="Check for updates" /></button> </div> </div> <div class="article__authors"> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3AHannah%20E.%20Straker">Hannah E. Straker</a>, <span class="orcid ver-b"><a target="_blank" title="Select to open ORCID record for Hannah E. Straker (orcid.org/0000-0003-0045-4523) in a new window" href="https://orcid.org/0000-0003-0045-4523"><img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/orcid_16x16.png" alt="ORCID logo"></a></span> *<span><sup><i>a</i></sup></span>   </span> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3ALynn%20McMillan">Lynn McMillan</a>,*<span><sup><i>a</i></sup></span>   </span> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3ALina%20Mardiana">Lina Mardiana</a>, <span class="orcid ver-b"><a target="_blank" title="Select to open ORCID record for Lina Mardiana (orcid.org/0000-0002-6639-4634) in a new window" href="https://orcid.org/0000-0002-6639-4634"><img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/orcid_16x16.png" alt="ORCID logo"></a></span> <span><sup><i>bcd</i></sup></span>   </span> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3AGlen%20R.%20Hebberd">Glen R. 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Waddell</a>, <span class="orcid ver-b"><a target="_blank" title="Select to open ORCID record for Paul G. Waddell (orcid.org/0000-0002-7851-7347) in a new window" href="https://orcid.org/0000-0002-7851-7347"><img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/orcid_16x16.png" alt="ORCID logo"></a></span> <span><sup><i>c</i></sup></span>   </span> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3AMichael%20R.%20Probert">Michael R. Probert</a> <span class="orcid ver-b"><a target="_blank" title="Select to open ORCID record for Michael R. Probert (orcid.org/0000-0002-2412-7917) in a new window" href="https://orcid.org/0000-0002-2412-7917"><img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/orcid_16x16.png" alt="ORCID logo"></a></span> *<span><sup><i>bc</i></sup></span>  and  </span> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3AMichael%20J.%20Hall">Michael J. Hall</a> <span class="orcid ver-b"><a target="_blank" title="Select to open ORCID record for Michael J. Hall (orcid.org/0000-0001-6475-9161) in a new window" href="https://orcid.org/0000-0001-6475-9161"><img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/orcid_16x16.png" alt="ORCID logo"></a></span> *<span><sup><i>bc</i></sup></span>   </span> </div> <div class="drawer-control fixpadv--m"> <a href="#" role="button" id="btnAuthorAffiliations" aria-expanded="false" aria-controls="pnlAuthorAffiliations" class="drawer__handle"> <span class="drawer__icon"></span> Author affiliations </a> <div class="drawer__content" id="pnlAuthorAffiliations" aria-labelledby="btnAuthorAffiliations"> <div> <p class="article__author-affiliation"> <span> * </span> <span> Corresponding authors </span> </p> <p class="article__author-affiliation"> <span> <sup>a</sup> </span> <span> Jazz Pharmaceuticals, Kent Science Park, Sittingbourne, Kent, UK <br /> <b>E-mail:</b> <a href="mailto:hannah.straker@jazzpharma.com" title="hannah.straker@jazzpharma.com">hannah.straker@jazzpharma.com</a>, <a href="mailto:lynn.mcmillan@jazzpharma.com" title="lynn.mcmillan@jazzpharma.com">lynn.mcmillan@jazzpharma.com</a> </span> </p> <p class="article__author-affiliation"> <span> <sup>b</sup> </span> <span> Indicatrix Crystallography Ltd, Bedson Building, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK <br /> <b>E-mail:</b> <a href="mailto:michael.probert@newcastle.ac.uk" title="michael.probert@newcastle.ac.uk">michael.probert@newcastle.ac.uk</a>, <a href="mailto:michael.hall@newcastle.ac.uk" title="michael.hall@newcastle.ac.uk">michael.hall@newcastle.ac.uk</a> </span> </p> <p class="article__author-affiliation"> <span> <sup>c</sup> </span> <span> Chemistry – School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK </span> </p> <p class="article__author-affiliation"> <span> <sup>d</sup> </span> <span> Department of Chemistry, Universitas Indonesia, Depok, Jawa Barat, Indonesia </span> </p> </div> </div> </div> <h3 class="h--heading3 article-abstract__heading">Abstract</h3> <div class="capsule__column-wrapper"> <div class="capsule__text"> <p xmlns="http://www.rsc.org/schema/rscart38">Cannabidiol (CBD) is a naturally occurring phytocannabinoid, approved for use in the US and other countries for the treatment of seizures associated with Dravet syndrome, Lennox–Gastaut syndrome and tuberous sclerosis complex, and is commonly isolated and used in its well-known stable crystalline form (form 1). We present a study of the crystal structures of an homologous series of CBD analogues, containing variations in the alkyl sidechain at C-5′, which shows that CBD form 1 is an unusual structural outlier. CBD C-5′ homologues display homologous isomorphism, existing as isomorphic variants in the solid state, whereas CBD form 1 shows notably different crystal packing, suggesting the potential existence of a previously uncharacterized isomorphic CBD polymorph. This predicted isomorphic CBD polymorph (form 2) was subsequently discovered through the use of high throughput crystallisation techniques (ENaCt) in combination with CBD homologue seeding, with single crystal X-ray diffraction analysis demonstrating its fit within the larger isomorphic series. This work represents the first example of directed polymorph discovery using high throughput ENaCt techniques.</p> </div> <div class="capsule__article-image fixpadv--s"> <img src="/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D3CE00041A&imageInfo.ImageIdentifier.Year=2023" alt="Graphical abstract: Polymorph prediction through observed structural isomorphism leading to a new crystalline form of cannabidiol" /> </div> </div> <p></p> <div id="pnlArticleAccess" class="article-access fixpadt--xxl" style="display: none; border: 0;"> <div class="article-access__inner" style="background-color: #F1F1F3;"> <div class="article-access__head fixpad--s"> This article is Open Access </div> <div class="fixpad--xl"> <div id="pnlViewFullArticleButton" class="paywall__body text--centered"> <div id="pnlArticleLoading"> <span id="thtmlLoadingMessage"> <img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/Ajax-GA-Loader.gif" alt="" class="ver-m" /> Please 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Polymorph prediction through observed structural isomorphism leading to a new crystalline form of cannabidiol - CrystEngComm (RSC Publishing)