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class="vector-toc-list"> <li id="toc-Gene" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Gene"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Gene</span> </div> </a> <ul id="toc-Gene-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Protein" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Protein"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.2</span> <span>Protein</span> </div> </a> <ul id="toc-Protein-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Expression" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Expression"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Expression</span> </div> </a> <ul id="toc-Expression-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Function" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Function"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Function</span> </div> </a> <ul id="toc-Function-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Clinical_significance" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Clinical_significance"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Clinical significance</span> </div> </a> <button aria-controls="toc-Clinical_significance-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Clinical significance subsection</span> </button> <ul id="toc-Clinical_significance-sublist" class="vector-toc-list"> <li id="toc-Clinical_marker" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Clinical_marker"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Clinical marker</span> </div> </a> <ul id="toc-Clinical_marker-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-As_a_drug_target" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#As_a_drug_target"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>As a drug target</span> </div> </a> <button aria-controls="toc-As_a_drug_target-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle As a drug target subsection</span> </button> <ul id="toc-As_a_drug_target-sublist" class="vector-toc-list"> <li id="toc-CYP17A1_inhibitors" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#CYP17A1_inhibitors"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>CYP17A1 inhibitors</span> </div> </a> <ul id="toc-CYP17A1_inhibitors-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Steroidogenesis" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Steroidogenesis"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Steroidogenesis</span> </div> </a> <ul id="toc-Steroidogenesis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Additional_images" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Additional_images"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Additional images</span> </div> </a> <ul id="toc-Additional_images-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div 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<div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Mammalian protein found in Homo sapiens</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Steroid 17-alpha-hydroxylase/17,20 lyase</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC no.</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.enzyme-database.org/query.php?ec=1.14.14.19">1.14.14.19</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/CAS_registry_number" class="mw-redirect" title="CAS registry number">CAS no.</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=9029-67-8&title=">9029-67-8 </a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Alt. names</th><td class="infobox-data" style="background-color: #eee">P450c17, CYP17A1, steroid 17-alpha-hydroxylase/17,20 lyase, CYPXVII, cytochrome P450 17A1, cytochrome p450 XVIIA1, cytochrome P450-C17, cytochrome P450, family 17, subfamily A, polypeptide 1, steroid 17-alpha-monooxygenase, cytochrome P450c17, 4.1.2.30, 17-alpha-hydroxyprogesterone aldolase, cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), steroid 17 alpha-hydroxylase/17,20 lyase, IPR033282</td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Databases</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/IntEnz" title="IntEnz">IntEnz</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=1.14.14.19">IntEnz view</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/BRENDA" title="BRENDA">BRENDA</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.brenda-enzymes.org/enzyme.php?ecno=1.14.14.19">BRENDA entry</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/ExPASy" class="mw-redirect" title="ExPASy">ExPASy</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/1.14.14.19">NiceZyme view</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genome.jp/dbget-bin/www_bget?enzyme+1.14.14.19">KEGG entry</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/MetaCyc" title="MetaCyc">MetaCyc</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://biocyc.org/META/substring-search?type=NIL&object=1.14.14.19">metabolic pathway</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/PRIAM_enzyme-specific_profiles" title="PRIAM enzyme-specific profiles">PRIAM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://priam.prabi.fr/cgi-bin/PRIAM_profiles_CurrentRelease.pl?EC=1.14.14.19">profile</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> structures</th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity.rcsb_ec_lineage.id:1.14.14.19">RCSB PDB</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?ec_number:1.14.14.19">PDBe</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=1.14.14.19">PDBsum</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=1.14.14.19%5BEC/RN%20Number%5D%20AND%20pubmed%20pmc%20local%5Bsb%5D">articles</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PubMed" title="PubMed">PubMed</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=1.14.14.19%5BEC/RN%20Number%5D">articles</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">NCBI</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein?term=1.14.14.19%5BEC/RN%20Number%5D">proteins</a></td></tr></tbody></table></td></tr></tbody></table><table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">CYP17A1</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:3ruk.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/c/cd/3ruk.png" decoding="async" width="250" height="318" class="mw-file-element" data-file-width="250" data-file-height="318" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P27786%20or%20P05093">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P27786,P05093">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3RUK">3RUK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3SWZ">3SWZ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4NKV">4NKV</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4NKW">4NKW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4NKX">4NKX</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4NKY">4NKY</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4NKZ">4NKZ</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/2593">CYP17A1</a></span>, CPT7, CYP17, P450C17, S17AH, cytochrome P450 family 17 subfamily A member 1</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/609300">609300</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:88586">88586</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=73875">73875</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP17A1">CYP17A1</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000148795">CYP17A1 - orthologs</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genome.jp/dbget-bin/www_bget?enzyme+1.14.14.19+">1.14.14.32 1.14.14.19, 1.14.14.32</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_10.svg" class="mw-file-description" title="Chromosome 10 (human)"><img alt="Chromosome 10 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/300px-Ideogram_human_chromosome_10.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/450px-Ideogram_human_chromosome_10.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/600px-Ideogram_human_chromosome_10.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_10_(human)" class="mw-redirect" title="Chromosome 10 (human)">Chromosome 10 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_10_ideogram.svg" class="mw-file-description" title="Chromosome 10 (human)"><img alt="Chromosome 10 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/300px-Human_chromosome_10_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/450px-Human_chromosome_10_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/600px-Human_chromosome_10_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 220.6648484692px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CYP17A1"><img alt="Genomic location for CYP17A1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 226.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CYP17A1"><img alt="Genomic location for CYP17A1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">10q24.32</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">102,830,531 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">102,837,472 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (mouse)"><img alt="Chromosome 19 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/260px-Ideogram_house_mouse_chromosome_19.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/390px-Ideogram_house_mouse_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/520px-Ideogram_house_mouse_chromosome_19.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 19 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (mouse)"><img alt="Chromosome 19 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/300px-Ideogram_of_house_mouse_chromosome_19.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/450px-Ideogram_of_house_mouse_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/600px-Ideogram_of_house_mouse_chromosome_19.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 218.00054836823px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CYP17A1"><img alt="Genomic location for CYP17A1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 224px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CYP17A1"><img alt="Genomic location for CYP17A1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">19 C3|19 38.97 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">46,655,604 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">46,661,611 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000148795">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right adrenal gland</li><br /><li style="line-height: 137%;">right adrenal cortex</li><br /><li style="line-height: 137%;">left adrenal cortex</li><br /><li style="line-height: 137%;">human kidney</li><br /><li style="line-height: 137%;">right testis</li><br /><li style="line-height: 137%;">right uterine tube</li><br /><li style="line-height: 137%;">right lobe of liver</li><br /><li style="line-height: 137%;">left testis</li><br /><li style="line-height: 137%;">right coronary artery</li><br /><li style="line-height: 137%;">left lobe of thyroid gland</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000003555">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">Gonadal ridge</li><br /><li style="line-height: 137%;">Leydig cell</li><br /><li style="line-height: 137%;">spermatocyte</li><br /><li style="line-height: 137%;">seminiferous tubule</li><br /><li style="line-height: 137%;">adrenal cortex</li><br /><li style="line-height: 137%;">placenta</li><br /><li style="line-height: 137%;">theca folliculi</li><br /><li style="line-height: 137%;">epithelium of epididymis</li><br /><li style="line-height: 137%;">lip</li><br /><li style="line-height: 137%;">decidua</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000148795">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_CYP17A1_205502_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/69/PBB_GE_CYP17A1_205502_at_fs.png/250px-PBB_GE_CYP17A1_205502_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/69/PBB_GE_CYP17A1_205502_at_fs.png/375px-PBB_GE_CYP17A1_205502_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/69/PBB_GE_CYP17A1_205502_at_fs.png/500px-PBB_GE_CYP17A1_205502_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/1586/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005506">iron ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019825">oxygen binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004508">steroid 17-alpha-monooxygenase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004497">monooxygenase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0020037">heme binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016705">oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016829">lyase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016491">oxidoreductase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0047442">17-alpha-hydroxyprogesterone aldolase activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005789">endoplasmic reticulum membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030424">axon</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043025">soma</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005783">endoplasmic reticulum</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042448">progesterone metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006702">androgen biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006704">glucocorticoid biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016125">sterol metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042446">hormone biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006694">steroid biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008202">steroid metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007548">sex differentiation</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=1586&rn=1">1586</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=13074&rn=1">13074</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000148795;db=core">ENSG00000148795</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000003555;db=core">ENSMUSG00000003555</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P05093">P05093</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P27786">P27786</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000102">NM_000102</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007809">NM_007809</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000093">NP_000093</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_031835">NP_031835</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr10:102830531-102837472">Chr 10: 102.83 – 102.84 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr19:46655604-46661611">Chr 19: 46.66 – 46.66 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14905207" class="extiw" title="d:Q14905207">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14905208" class="extiw" title="d:Q14905208">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table><p><b>Cytochrome P450 17A1</b> (<b>steroid 17α-monooxygenase</b>, <b>17α-hydroxylase</b>, <b>17-alpha-hydroxylase</b>, <b>17,20-lyase</b>, <b>17,20-desmolase</b>) is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> of the <a href="/wiki/Hydroxylation" title="Hydroxylation">hydroxylase</a> type that in humans is encoded by the <i>CYP17A1</i> <a href="/wiki/Gene" title="Gene">gene</a> on <a href="/wiki/Chromosome_10_(human)" class="mw-redirect" title="Chromosome 10 (human)">chromosome 10</a>.<sup id="cite_ref-:0_5-0" class="reference"><a href="#cite_note-:0-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> It is ubiquitously expressed in many tissues and cell types, including the <a href="/wiki/Zona_reticularis" title="Zona reticularis">zona reticularis</a> and <a href="/wiki/Zona_fasciculata" title="Zona fasciculata">zona fasciculata</a> (but not <a href="/wiki/Zona_glomerulosa" title="Zona glomerulosa">zona glomerulosa</a>) of the <a href="/wiki/Adrenal_cortex" title="Adrenal cortex">adrenal cortex</a> as well as <a href="/wiki/Gonad" title="Gonad">gonadal</a> tissues.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-isbn1-4160-2328-3_7-0" class="reference"><a href="#cite_note-isbn1-4160-2328-3-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It has both 17α-hydroxylase and 17,20-lyase activities, and is a key enzyme in the steroidogenic pathway that produces <a href="/wiki/Progestin" class="mw-redirect" title="Progestin">progestins</a>, <a href="/wiki/Mineralocorticoid" title="Mineralocorticoid">mineralocorticoids</a>, <a href="/wiki/Glucocorticoid" title="Glucocorticoid">glucocorticoids</a>, <a href="/wiki/Androgen" title="Androgen">androgens</a>, and <a href="/wiki/Estrogen" title="Estrogen">estrogens</a>. More specifically, the enzyme acts upon <a href="/wiki/Pregnenolone" title="Pregnenolone">pregnenolone</a> and <a href="/wiki/Progesterone" title="Progesterone">progesterone</a> to add a <a href="/wiki/Hydroxyl" class="mw-redirect" title="Hydroxyl">hydroxyl</a> (-OH) group at carbon 17 position (C17) of the steroid D ring (the 17α-hydroxylase activity, <a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> <a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/1.14.14.19">1.14.14.19</a>), or acts upon <a href="/wiki/17%CE%B1-hydroxyprogesterone" class="mw-redirect" title="17α-hydroxyprogesterone">17α-hydroxyprogesterone</a> and <a href="/wiki/17%CE%B1-hydroxypregnenolone" class="mw-redirect" title="17α-hydroxypregnenolone">17α-hydroxypregnenolone</a> to split the side-chain off the steroid nucleus (the 17,20-<a href="/wiki/Lyase" title="Lyase">lyase</a> activity, <a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> <a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/1.14.14.32">1.14.14.32</a>).<sup id="cite_ref-isbn1-4160-2328-3_7-1" class="reference"><a href="#cite_note-isbn1-4160-2328-3-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Gene">Gene</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=2" title="Edit section: Gene"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <i>CYP17A1</i> gene resides on chromosome 10 at the band 10q24.3 and contains 8 <a href="/wiki/Exon" title="Exon">exons</a>.<sup id="cite_ref-:0_5-1" class="reference"><a href="#cite_note-:0-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The <a href="/wiki/CDNA" class="mw-redirect" title="CDNA">cDNA</a> of this gene spans a length of 1527 <a href="/wiki/Base_pair" title="Base pair">bp</a>.<sup id="cite_ref-:1_8-0" class="reference"><a href="#cite_note-:1-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> This gene encodes a member of the <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> superfamily of enzymes. The cytochrome P450 proteins are generally regarded as <a href="/wiki/Monooxygenase" title="Monooxygenase">monooxygenases</a> that catalyze many reactions involved in drug metabolism and synthesis of <a href="/wiki/Cholesterol" title="Cholesterol">cholesterol</a>, <a href="/wiki/Steroid" title="Steroid">steroids</a>, and other <a href="/wiki/Lipid" title="Lipid">lipids</a>, including the remarkable carbon-carbon bond scission catalyzed by this enzyme. </p><p>The <i>CYP17A1</i> gene may also contain variants associated with increased risk of <a href="/wiki/Coronary_artery_disease" title="Coronary artery disease">coronary artery disease</a>.<sup id="cite_ref-ReferenceA_9-0" class="reference"><a href="#cite_note-ReferenceA-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup class="noprint Inline-Template noprint Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:No_original_research#Primary,_secondary_and_tertiary_sources" title="Wikipedia:No original research"><span title="This claim needs references to reliable secondary sources. (November 2020)">non-primary source needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading3"><h3 id="Protein">Protein</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=3" title="Edit section: Protein"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>CYP17A1 is a 57.4 <a href="/wiki/KDa" class="mw-redirect" title="KDa">kDa</a> protein that belongs to the cytochrome P450 family.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> The protein encoded by its cDNA is composed of 508 <a href="/wiki/Amino_acid_residues" class="mw-redirect" title="Amino acid residues">amino acid residues</a>. As an enzyme, CYP17A1 possesses an <a href="/wiki/Active_site" title="Active site">active site</a> that associates with a <a href="/wiki/Heme" title="Heme">heme</a> prosthetic group to catalyze biosynthetic reactions.<sup id="cite_ref-:1_8-1" class="reference"><a href="#cite_note-:1-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Based on its known structures while bound to two <a href="/wiki/Steroidal" class="mw-redirect" title="Steroidal">steroidal</a> inhibitors, <a href="/wiki/Abiraterone" class="mw-redirect" title="Abiraterone">abiraterone</a> and <a href="/wiki/Galeterone" title="Galeterone">galeterone</a>, CYP17A1 possesses the canonical cytochrome P450 fold present in other complex P450 enzymes that participate in <a href="/wiki/Steroidogenesis" class="mw-redirect" title="Steroidogenesis">steroidogenesis</a> or <a href="/wiki/Cholesterol" title="Cholesterol">cholesterol</a> metabolism, though it orients the steroid ligands toward the F and G helices, perpendicular to the heme group, rather than the β1 sheet.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Expression">Expression</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=4" title="Edit section: Expression"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Gene_expression" title="Gene expression">Expression</a> of CYP17A1 has been found in all of the traditional <a href="/wiki/Steroidogenic" class="mw-redirect" title="Steroidogenic">steroidogenic</a> <a href="/wiki/Tissue_(biology)" title="Tissue (biology)">tissues</a> except the <a href="/wiki/Placenta" title="Placenta">placenta</a>, including the <a href="/wiki/Zona_reticularis" title="Zona reticularis">zona reticularis</a> and <a href="/wiki/Zona_fasciculata" title="Zona fasciculata">zona fasciculata</a> of the <a href="/wiki/Adrenal_cortex" title="Adrenal cortex">adrenal cortex</a>, the <a href="/wiki/Leydig_cell" title="Leydig cell">Leydig cells</a> of the <a href="/wiki/Testicle" title="Testicle">testes</a>, the <a href="/wiki/Thecal_cell" class="mw-redirect" title="Thecal cell">thecal cells</a> of the <a href="/wiki/Ovary" title="Ovary">ovaries</a>, and, more recently, in <a href="/wiki/Luteinization" class="mw-redirect" title="Luteinization">luteinized</a> <a href="/wiki/Granulosa_cell" title="Granulosa cell">granulosa cells</a> in <a href="/wiki/Ovarian_follicle" title="Ovarian follicle">ovarian follicles</a>.<sup id="cite_ref-pmid21095220_14-0" class="reference"><a href="#cite_note-pmid21095220-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> In addition to classical steroidogenic tissue, CYP17A1 has also been detected in the <a href="/wiki/Heart" title="Heart">heart</a>, <a href="/wiki/Kidney" title="Kidney">kidney</a>, and <a href="/wiki/Adipose_tissue" title="Adipose tissue">adipose tissue</a>.<sup id="cite_ref-pmid21095220_14-1" class="reference"><a href="#cite_note-pmid21095220-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> In the <a href="/wiki/Fetus" title="Fetus">fetus</a>, CYP17A1 has been reported in the kidney, <a href="/wiki/Thymus" title="Thymus">thymus</a>, and <a href="/wiki/Spleen" title="Spleen">spleen</a>.<sup id="cite_ref-pmid21095220_14-2" class="reference"><a href="#cite_note-pmid21095220-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=5" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>CYP17A1 is a member of the <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> superfamily of enzymes localized in the <a href="/wiki/Endoplasmic_reticulum" title="Endoplasmic reticulum">endoplasmic reticulum</a>. Proteins in this family are monooxygenases that catalyze synthesis of <a href="/wiki/Cholesterol" title="Cholesterol">cholesterol</a>, <a href="/wiki/Steroid" title="Steroid">steroids</a> and other lipids and are involved in drug metabolism.<sup id="cite_ref-:0_5-2" class="reference"><a href="#cite_note-:0-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> CYP17A1 has both 17α-hydroxylase activity (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> <a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/1.14.14.19">1.14.14.19</a>) and 17,20-lyase activity (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> <a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/1.14.14.32">1.14.14.32</a>). The 17α-hydroxylase activity of CYP17A1 is required for the generation of <a href="/wiki/Glucocorticoid" title="Glucocorticoid">glucocorticoids</a> such as cortisol, but both the hydroxylase and 17,20-lyase activities of CYP17A1 are required for the production of <a href="/wiki/Androgen" title="Androgen">androgenic</a> and <a href="/wiki/Oestrogenine" class="mw-redirect" title="Oestrogenine">oestrogenic</a> sex steroids by converting <a href="/wiki/17%CE%B1-hydroxypregnenolone" class="mw-redirect" title="17α-hydroxypregnenolone">17α-hydroxypregnenolone</a> to <a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">dehydroepiandrosterone (DHEA)</a>.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Mutations in this gene are associated with isolated steroid-17α-hydroxylase deficiency, 17α-hydroxylase/17,20-lyase deficiency, <a href="/wiki/Pseudohermaphroditism" title="Pseudohermaphroditism">pseudohermaphroditism</a>, and <a href="/wiki/Congenital_adrenal_hyperplasia" title="Congenital adrenal hyperplasia">adrenal hyperplasia</a>.<sup id="cite_ref-:0_5-3" class="reference"><a href="#cite_note-:0-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>Furthermore, the 17,20-lyase activity is dependent on cytochrome <a href="/wiki/Cytochrome_P450_reductase" title="Cytochrome P450 reductase">P450 oxidoreductase</a> (POR) cytochrome b5 (CYB5) and <a href="/wiki/Phosphorylation" title="Phosphorylation">phosphorylation</a>.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ReferenceB_18-0" class="reference"><a href="#cite_note-ReferenceB-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> Cytochrome b5 acts as a facilitator for 17,20 lyase activity of CYP17A1 and can donate a second electron to some P450s. In humans the production of <a href="/wiki/Testosterone" title="Testosterone">testosterone</a> via pregnenolone to17-OHPreg and DHEA by the CYP17A1 requires POR.<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-wj_20-0" class="reference"><a href="#cite_note-wj-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> Human CYP17A1 protein is <a href="/wiki/Protein_phosphorylation" title="Protein phosphorylation">phosphorylated</a> on serine and threonine residues by a <a href="/wiki/CAMP-dependent_protein_kinase_A" class="mw-redirect" title="CAMP-dependent protein kinase A">cAMP-dependent protein kinase</a>. Phosphorylation of the protein increases 17,20-lyase activity, while dephosphorylation virtually eliminates this activity.<sup id="cite_ref-ReferenceB_18-1" class="reference"><a href="#cite_note-ReferenceB-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=6" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Mutations in this gene are associated with rare forms of <a href="/wiki/Congenital_adrenal_hyperplasia" title="Congenital adrenal hyperplasia">congenital adrenal hyperplasia</a>, specifically <a href="/wiki/Congenital_adrenal_hyperplasia_due_to_17%CE%B1-hydroxylase_deficiency" title="Congenital adrenal hyperplasia due to 17α-hydroxylase deficiency">17α-hydroxylase deficiency/17,20-lyase deficiency</a> and <a href="/wiki/Isolated_17,20-lyase_deficiency" title="Isolated 17,20-lyase deficiency">isolated 17,20-lyase deficiency</a>.<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p><p>In humans, the CYP17A1 gene is largely associated with endocrine effects and steroid hormone metabolism.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> Furthermore, mutations in the CYP17A1 gene are associated with rare forms of <a href="/wiki/Congenital_adrenal_hyperplasia_due_to_17%CE%B1-hydroxylase_deficiency" title="Congenital adrenal hyperplasia due to 17α-hydroxylase deficiency">congenital adrenal hyperplasia</a>, in particular 17α-hydroxylase deficiency/17,20-lyase deficiency and isolated 17,20-lyase deficiency. Overall, CYP17A1 is an important target for inhibition in the treatment of prostate cancer because it produces androgen that is required for tumor cell growth.<sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Bonomo_2016_26-0" class="reference"><a href="#cite_note-Bonomo_2016-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> The decreased enzyme activity of CYP17A1 is related to infertility due to hypogonadotropic hypogonadism. In females, folliculogenesis is arrested, while in males, testicular atrophy with interstitial cell proliferation and arrested spermatogenesis. Although generally anovulatory, there are some case reports of women with 17α-hydroxylase deficiency who underwent spontaneous menarche with cyclic menses.<sup id="cite_ref-pmid33158283_27-0" class="reference"><a href="#cite_note-pmid33158283-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> </p> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Congenital_adrenal_hyperplasia_due_to_17%CE%B1-hydroxylase_deficiency" title="Congenital adrenal hyperplasia due to 17α-hydroxylase deficiency">Congenital adrenal hyperplasia due to 17α-hydroxylase deficiency</a></div> <div class="mw-heading mw-heading3"><h3 id="Clinical_marker">Clinical marker</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=7" title="Edit section: Clinical marker"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A multi-locus genetic risk score study based on a combination of 27 loci, including the CYP17A1 gene, identified individuals at increased risk for both incident and recurrent coronary artery disease events, as well as an enhanced clinical benefit from statin therapy. The study was based on a community cohort study (the Malmo Diet and Cancer study) and four additional randomized controlled trials of primary prevention cohorts (JUPITER and ASCOT) and secondary prevention cohorts (CARE and PROVE IT-TIMI 22).<sup id="cite_ref-ReferenceA_9-1" class="reference"><a href="#cite_note-ReferenceA-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="As_a_drug_target">As a drug target</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=8" title="Edit section: As a drug target"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="CYP17A1_inhibitors">CYP17A1 inhibitors</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=9" title="Edit section: CYP17A1 inhibitors"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/CYP17A1_inhibitor" title="CYP17A1 inhibitor">CYP17A1 inhibitor</a></div> <p>Currently,<sup class="noprint Inline-Template" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Manual_of_Style/Dates_and_numbers#Chronological_items" title="Wikipedia:Manual of Style/Dates and numbers"><span title="The time period mentioned near this tag is ambiguous. (November 2020)">when?</span></a></i>]</sup> the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal scaffold that is similar to the endogenous CYP17A1 substrates. Abiraterone is structurally similar to the substrates of other cytochrome P450 enzymes involved in steroidogenesis, and interference can pose a liability in terms of side effects. Using <a href="/wiki/Nonsteroidal" title="Nonsteroidal">nonsteroidal</a> scaffolds is expected to enable the design of compounds that interact more selectively with CYP17A1.<sup id="cite_ref-Bonomo_2016_26-1" class="reference"><a href="#cite_note-Bonomo_2016-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> Potent inhibitors of the CYP17A1 enzyme provide a last line defense against ectopic androgenesis in advanced prostate cancer.<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> </p><p>The drug <a href="/wiki/Abiraterone_acetate" title="Abiraterone acetate">abiraterone acetate</a>, which is used to treat <a href="/wiki/Castration-resistant_prostate_cancer" class="mw-redirect" title="Castration-resistant prostate cancer">castration-resistant prostate cancer</a>, blocks the biosynthesis of androgens by inhibiting the CYP17A1 enzyme. Abiraterone acetate binds in the active site of the enzyme<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> and coordinates the <a href="/wiki/Heme" title="Heme">heme</a> iron through its pyridine nitrogen, mimicking the substrate.<sup id="cite_ref-pmid22266943_30-0" class="reference"><a href="#cite_note-pmid22266943-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> </p><p>Since 2014, <a href="/wiki/Galeterone" title="Galeterone">galeterone</a> has been in <a href="/wiki/Phase_III_clinical_trials" class="mw-redirect" title="Phase III clinical trials">phase III</a> <a href="/wiki/Clinical_trial" title="Clinical trial">clinical trials</a> for <a href="/wiki/Castration-resistant_prostate_cancer" class="mw-redirect" title="Castration-resistant prostate cancer">castration-resistant prostate cancer</a>.<sup id="cite_ref-Tokai2014_31-0" class="reference"><a href="#cite_note-Tokai2014-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Ketoconazole" title="Ketoconazole">Ketoconazole</a> is an older <a href="/wiki/CYP17A1_inhibitor" title="CYP17A1 inhibitor">CYP17A1 inhibitor</a> that is now little used. However, ketoconazole competitively inhibits CYP17A1, therefore its effectiveness will depend on the concentration of ketoconazole. This is in contrast to the <a href="/wiki/Abiraterone_acetate" title="Abiraterone acetate">abiraterone acetate</a>, that permanently (rather than competitively) disables CYP17A1, once it binds to it. </p><p><a href="/wiki/Seviteronel" title="Seviteronel">Seviteronel</a> (VT-464) is a novel <a href="/wiki/CYP17A1_inhibitor" title="CYP17A1 inhibitor">CYP17A1 inhibitor</a> which is aimed to avoid co-administration of glucocortoid therapy.<sup id="cite_ref-pmid27154414_32-0" class="reference"><a href="#cite_note-pmid27154414-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> In the 2010s it underwent various phases of clinical studies and preclinical models as a drug against prostate cancer or breast cancer.<sup id="cite_ref-pmid32327394_33-0" class="reference"><a href="#cite_note-pmid32327394-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid31367790_34-0" class="reference"><a href="#cite_note-pmid31367790-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Steroidogenesis">Steroidogenesis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=10" title="Edit section: Steroidogenesis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <table> <tbody><tr> <td><figure class="mw-halign-none" typeof="mw:File/Thumb"><a href="/wiki/File:Steroidogenesis.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Steroidogenesis.svg/600px-Steroidogenesis.svg.png" decoding="async" width="600" height="533" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Steroidogenesis.svg/900px-Steroidogenesis.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/13/Steroidogenesis.svg/1200px-Steroidogenesis.svg.png 2x" data-file-width="1245" data-file-height="1105" /></a><figcaption><a href="/wiki/Steroidogenesis" class="mw-redirect" title="Steroidogenesis">Steroidogenesis</a>, showing, at left side, both reactions of 17α-hydroxylase, and both actions of 17, 20 lyase.</figcaption></figure> </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Additional_images">Additional images</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=11" title="Edit section: Additional images"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul class="gallery mw-gallery-traditional"> <li class="gallerybox" style="width: 155px"> <div class="thumb" style="width: 150px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:Pregnenolone.svg" class="mw-file-description" title="Pregnenolone"><img alt="Pregnenolone" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/14/Pregnenolone.svg/120px-Pregnenolone.svg.png" decoding="async" width="120" height="75" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/14/Pregnenolone.svg/180px-Pregnenolone.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/14/Pregnenolone.svg/240px-Pregnenolone.svg.png 2x" data-file-width="512" data-file-height="319" /></a></span></div> <div class="gallerytext"><a href="/wiki/Pregnenolone" title="Pregnenolone">Pregnenolone</a></div> </li> <li class="gallerybox" style="width: 155px"> <div class="thumb" style="width: 150px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:17-Hydroxypregnenolone.svg" class="mw-file-description" title="17α-Hydroxypregnenolone"><img alt="17α-Hydroxypregnenolone" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/87/17-Hydroxypregnenolone.svg/120px-17-Hydroxypregnenolone.svg.png" decoding="async" width="120" height="73" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/87/17-Hydroxypregnenolone.svg/180px-17-Hydroxypregnenolone.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/87/17-Hydroxypregnenolone.svg/240px-17-Hydroxypregnenolone.svg.png 2x" data-file-width="512" data-file-height="311" /></a></span></div> <div class="gallerytext"><a href="/wiki/17%CE%B1-Hydroxypregnenolone" title="17α-Hydroxypregnenolone">17α-Hydroxypregnenolone</a></div> </li> <li class="gallerybox" style="width: 155px"> <div class="thumb" style="width: 150px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:Progesterone.svg" class="mw-file-description" title="Progesterone"><img alt="Progesterone" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/Progesterone.svg/120px-Progesterone.svg.png" decoding="async" width="120" height="88" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/Progesterone.svg/180px-Progesterone.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a8/Progesterone.svg/240px-Progesterone.svg.png 2x" data-file-width="512" data-file-height="377" /></a></span></div> <div class="gallerytext"><a href="/wiki/Progesterone" title="Progesterone">Progesterone</a></div> </li> <li class="gallerybox" style="width: 155px"> <div class="thumb" style="width: 150px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:17-Hydroxyprogesterone.svg" class="mw-file-description" title="17α-Hydroxyprogesterone"><img alt="17α-Hydroxyprogesterone" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fc/17-Hydroxyprogesterone.svg/120px-17-Hydroxyprogesterone.svg.png" decoding="async" width="120" height="86" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fc/17-Hydroxyprogesterone.svg/180px-17-Hydroxyprogesterone.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fc/17-Hydroxyprogesterone.svg/240px-17-Hydroxyprogesterone.svg.png 2x" data-file-width="512" data-file-height="368" /></a></span></div> <div class="gallerytext"><a href="/wiki/17%CE%B1-Hydroxyprogesterone" title="17α-Hydroxyprogesterone">17α-Hydroxyprogesterone</a></div> </li> <li class="gallerybox" style="width: 155px"> <div class="thumb" style="width: 150px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:Trimethyl_steroid-nomenclature.svg" class="mw-file-description" title="Steroid numbering"><img alt="Steroid numbering" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fa/Trimethyl_steroid-nomenclature.svg/120px-Trimethyl_steroid-nomenclature.svg.png" decoding="async" width="120" height="92" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fa/Trimethyl_steroid-nomenclature.svg/180px-Trimethyl_steroid-nomenclature.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fa/Trimethyl_steroid-nomenclature.svg/240px-Trimethyl_steroid-nomenclature.svg.png 2x" data-file-width="427" data-file-height="326" /></a></span></div> <div class="gallerytext">Steroid numbering</div> </li> </ul> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=12" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239009302">.mw-parser-output .portalbox{padding:0;margin:0.5em 0;display:table;box-sizing:border-box;max-width:175px;list-style:none}.mw-parser-output .portalborder{border:1px solid var(--border-color-base,#a2a9b1);padding:0.1em;background:var(--background-color-neutral-subtle,#f8f9fa)}.mw-parser-output .portalbox-entry{display:table-row;font-size:85%;line-height:110%;height:1.9em;font-style:italic;font-weight:bold}.mw-parser-output .portalbox-image{display:table-cell;padding:0.2em;vertical-align:middle;text-align:center}.mw-parser-output .portalbox-link{display:table-cell;padding:0.2em 0.2em 0.2em 0.3em;vertical-align:middle}@media(min-width:720px){.mw-parser-output .portalleft{clear:left;float:left;margin:0.5em 1em 0.5em 0}.mw-parser-output .portalright{clear:right;float:right;margin:0.5em 0 0.5em 1em}}</style><ul role="navigation" aria-label="Portals" class="noprint portalbox portalborder portalright"> <li class="portalbox-entry"><span class="portalbox-image"><span class="noviewer" typeof="mw:File"><a href="/wiki/File:Issoria_lathonia.jpg" class="mw-file-description"><img alt="icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Issoria_lathonia.jpg/32px-Issoria_lathonia.jpg" decoding="async" width="32" height="23" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Issoria_lathonia.jpg/48px-Issoria_lathonia.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Issoria_lathonia.jpg/64px-Issoria_lathonia.jpg 2x" data-file-width="629" data-file-height="445" /></a></span></span><span class="portalbox-link"><a href="/wiki/Portal:Biology" title="Portal:Biology">Biology portal</a></span></li></ul> <ul><li><a href="/wiki/Steroidogenic_enzyme" title="Steroidogenic enzyme">Steroidogenic enzyme</a></li> <li><a href="/wiki/Cytochrome_P450_oxidoreductase_deficiency" title="Cytochrome P450 oxidoreductase deficiency">Cytochrome P450 oxidoreductase deficiency</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=13" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000148795">GRCh38: Ensembl release 89: ENSG00000148795</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000003555">GRCm38: Ensembl release 89: ENSMUSG00000003555</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=1586">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span 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Retrieved <span class="nowrap">2016-09-27</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.ncbi.nlm.nih.gov&rft.atitle=CYP17A1+cytochrome+P450+family+17+subfamily+A+member+1+%5BHomo+sapiens+%28human%29%5D+-+Gene+-+NCBI&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F1586&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP17A1" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://biogps.org/#goto=genereport&id=1586">"BioGPS - your Gene Portal System"</a>. <i>biogps.org</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20110820062552/http://biogps.org/#goto=genereport&id=1586">Archived</a> from the original on 2011-08-20<span class="reference-accessdate">. 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Together with the clear lack of suppression of circulating cortisol in nonhuman primates, these data argue that VT464 may indeed be a selective 17,20 lyase inhibitor.</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Steroid+Biochemistry+and+Molecular+Biology&rft.atitle=The+hunt+for+a+selective+17%2C20+lyase+inhibitor%3B+learning+lessons+from+nature&rft.volume=163&rft.pages=136-146&rft.date=2016-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5046225%23id-name%3DPMC&rft_id=info%3Apmid%2F27154414&rft_id=info%3Adoi%2F10.1016%2Fj.jsbmb.2016.04.021&rft.aulast=Bird&rft.aufirst=IM&rft.au=Abbott%2C+DH&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5046225&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP17A1" class="Z3988"></span></span> </li> <li id="cite_note-pmid32327394-33"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid32327394_33-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMadanSchmidtKarzaiPeer2020" class="citation journal cs1">Madan RA, Schmidt KT, Karzai F, Peer CJ, Cordes LM, Chau CH, et al. 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(October 2019). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132106">"A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer"</a>. <i>Cancer Chemotherapy and Pharmacology</i>. <b>84</b> (4): 759–770. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00280-019-03908-0">10.1007/s00280-019-03908-0</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132106">8132106</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/31367790">31367790</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:199056344">199056344</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Chemotherapy+and+Pharmacology&rft.atitle=A+population+pharmacokinetic+analysis+of+the+oral+CYP17+lyase+and+androgen+receptor+inhibitor+seviteronel+in+patients+with+advanced%2Fmetastatic+castration-resistant+prostate+cancer+or+breast+cancer&rft.volume=84&rft.issue=4&rft.pages=759-770&rft.date=2019-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8132106%23id-name%3DPMC&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A199056344%23id-name%3DS2CID&rft_id=info%3Apmid%2F31367790&rft_id=info%3Adoi%2F10.1007%2Fs00280-019-03908-0&rft.aulast=Peer&rft.aufirst=CJ&rft.au=Schmidt%2C+KT&rft.au=Kindrick%2C+JD&rft.au=Eisner%2C+JR&rft.au=Brown%2C+VV&rft.au=Baskin-Bey%2C+E&rft.au=Madan%2C+R&rft.au=Figg%2C+WD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8132106&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP17A1" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=14" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMiuraYasudaYanaseYamakita1996" class="citation journal cs1">Miura K, Yasuda K, Yanase T, Yamakita N, Sasano H, Nawata H, et al. (October 1996). <a rel="nofollow" class="external text" href="https://doi.org/10.1210%2Fjcem.81.10.8855840">"Mutation of cytochrome P-45017 alpha gene (CYP17) in a Japanese patient previously reported as having glucocorticoid-responsive hyperaldosteronism: with a review of Japanese patients with mutations of CYP17"</a>. <i>The Journal of Clinical Endocrinology and Metabolism</i>. <b>81</b> (10): 3797–3801. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1210%2Fjcem.81.10.8855840">10.1210/jcem.81.10.8855840</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8855840">8855840</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Clinical+Endocrinology+and+Metabolism&rft.atitle=Mutation+of+cytochrome+P-45017+alpha+gene+%28CYP17%29+in+a+Japanese+patient+previously+reported+as+having+glucocorticoid-responsive+hyperaldosteronism%3A+with+a+review+of+Japanese+patients+with+mutations+of+CYP17&rft.volume=81&rft.issue=10&rft.pages=3797-3801&rft.date=1996-10&rft_id=info%3Adoi%2F10.1210%2Fjcem.81.10.8855840&rft_id=info%3Apmid%2F8855840&rft.aulast=Miura&rft.aufirst=K&rft.au=Yasuda%2C+K&rft.au=Yanase%2C+T&rft.au=Yamakita%2C+N&rft.au=Sasano%2C+H&rft.au=Nawata%2C+H&rft.au=Inoue%2C+M&rft.au=Fukaya%2C+T&rft.au=Shizuta%2C+Y&rft_id=https%3A%2F%2Fdoi.org%2F10.1210%252Fjcem.81.10.8855840&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP17A1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMillerGellerAuchus1999" class="citation journal cs1">Miller WL, Geller DH, Auchus RJ (1999). "The molecular basis of isolated 17,20 lyase deficiency". <i>Endocrine Research</i>. <b>24</b> (3–4): 817–825. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109%2F07435809809032692">10.3109/07435809809032692</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9888582">9888582</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Endocrine+Research&rft.atitle=The+molecular+basis+of+isolated+17%2C20+lyase+deficiency&rft.volume=24&rft.issue=3%E2%80%934&rft.pages=817-825&rft.date=1999&rft_id=info%3Adoi%2F10.3109%2F07435809809032692&rft_id=info%3Apmid%2F9888582&rft.aulast=Miller&rft.aufirst=WL&rft.au=Geller%2C+DH&rft.au=Auchus%2C+RJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP17A1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStrauss2003" class="citation journal cs1">Strauss JF (November 2003). "Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome". <i>Annals of the New York Academy of Sciences</i>. <b>997</b> (1): 42–48. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2003NYASA.997...42S">2003NYASA.997...42S</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1196%2Fannals.1290.005">10.1196/annals.1290.005</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14644808">14644808</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:23559461">23559461</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Some+new+thoughts+on+the+pathophysiology+and+genetics+of+polycystic+ovary+syndrome&rft.volume=997&rft.issue=1&rft.pages=42-48&rft.date=2003-11&rft_id=info%3Adoi%2F10.1196%2Fannals.1290.005&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A23559461%23id-name%3DS2CID&rft_id=info%3Apmid%2F14644808&rft_id=info%3Abibcode%2F2003NYASA.997...42S&rft.aulast=Strauss&rft.aufirst=JF&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP17A1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHaiderPatelPoojariNeidle2010" class="citation journal cs1">Haider SM, Patel JS, Poojari CS, Neidle S (July 2010). "Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy". <i>Journal of Molecular Biology</i>. <b>400</b> (5): 1078–1098. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jmb.2010.05.069">10.1016/j.jmb.2010.05.069</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20595043">20595043</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Molecular+modeling+on+inhibitor+complexes+and+active-site+dynamics+of+cytochrome+P450+C17%2C+a+target+for+prostate+cancer+therapy&rft.volume=400&rft.issue=5&rft.pages=1078-1098&rft.date=2010-07&rft_id=info%3Adoi%2F10.1016%2Fj.jmb.2010.05.069&rft_id=info%3Apmid%2F20595043&rft.aulast=Haider&rft.aufirst=SM&rft.au=Patel%2C+JS&rft.au=Poojari%2C+CS&rft.au=Neidle%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP17A1" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP17A1&action=edit&section=15" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=CYP17A1+protein%2C+human">CYP17A1+protein,+human</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CYP17A1"><i>CYP17A1</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CYP17A1"><i>CYP17A1</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist 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.navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cholesterol_and_steroid_metabolism_enzymes" title="Template:Cholesterol and steroid metabolism enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cholesterol_and_steroid_metabolism_enzymes" title="Template talk:Cholesterol and steroid metabolism enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cholesterol_and_steroid_metabolism_enzymes" title="Special:EditPage/Template:Cholesterol and steroid metabolism enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Metabolism:_lipid_metabolism_–_ketones/cholesterol_synthesis_enzymes/steroid_metabolism" style="font-size:114%;margin:0 4em"><a href="/wiki/Metabolism" title="Metabolism">Metabolism</a>: <a href="/wiki/Lipid_metabolism" title="Lipid metabolism">lipid metabolism</a> – <a href="/wiki/Ketone" title="Ketone">ketones</a>/<a href="/wiki/Cholesterol" title="Cholesterol">cholesterol</a> synthesis <a href="/wiki/Enzymes" class="mw-redirect" title="Enzymes">enzymes</a>/<a href="/wiki/Steroid_metabolism" class="mw-redirect" title="Steroid metabolism">steroid metabolism</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Mevalonate_pathway" title="Mevalonate pathway">Mevalonate pathway</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">To <a href="/wiki/HMG-CoA" title="HMG-CoA">HMG-CoA</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thiolase" title="Thiolase">Acetyl-Coenzyme A acetyltransferase</a></li> <li><a href="/wiki/HMG-CoA_synthase" class="mw-redirect" title="HMG-CoA synthase">HMG-CoA synthase</a> (regulated step)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Ketogenesis" title="Ketogenesis">Ketogenesis</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3-hydroxy-3-methylglutaryl-CoA_lyase" class="mw-redirect" title="3-hydroxy-3-methylglutaryl-CoA lyase">HMG-CoA lyase</a></li> <li><a href="/wiki/3-hydroxybutyrate_dehydrogenase" class="mw-redirect" title="3-hydroxybutyrate dehydrogenase">3-hydroxybutyrate dehydrogenase</a></li> <li><a href="/wiki/Thiophorase" class="mw-redirect" title="Thiophorase">Thiophorase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">To <a href="/wiki/Mevalonic_acid" title="Mevalonic acid">Mevalonic acid</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HMG-CoA_reductase" title="HMG-CoA reductase">HMG-CoA reductase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">To <a href="/wiki/Dimethylallyl_pyrophosphate" title="Dimethylallyl pyrophosphate">DMAPP</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mevalonate_kinase" title="Mevalonate kinase">Mevalonate kinase</a></li> <li><a href="/wiki/Phosphomevalonate_kinase" title="Phosphomevalonate kinase">Phosphomevalonate kinase</a></li> <li><a href="/wiki/Pyrophosphomevalonate_decarboxylase" class="mw-redirect" title="Pyrophosphomevalonate decarboxylase">Pyrophosphomevalonate decarboxylase</a></li> <li><a href="/wiki/Isopentenyl-diphosphate_delta_isomerase" title="Isopentenyl-diphosphate delta isomerase">Isopentenyl-diphosphate delta isomerase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Geranyl-</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dimethylallyltranstransferase" title="Dimethylallyltranstransferase">Dimethylallyltranstransferase</a></li> <li><a href="/wiki/Geranyl_pyrophosphate" title="Geranyl pyrophosphate">Geranyl pyrophosphate</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">To <a href="/wiki/Cholesterol" title="Cholesterol">cholesterol</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">To <a href="/wiki/Lanosterol" title="Lanosterol">lanosterol</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Farnesyl-diphosphate_farnesyltransferase" title="Farnesyl-diphosphate farnesyltransferase">Farnesyl-diphosphate farnesyltransferase</a></li> <li><a href="/wiki/Squalene_monooxygenase" title="Squalene monooxygenase">Squalene monooxygenase</a></li> <li><a href="/wiki/Lanosterol_synthase" title="Lanosterol synthase">Lanosterol synthase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/7-Dehydrocholesterol" title="7-Dehydrocholesterol">7-Dehydrocholesterol</a> path</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lanosterol_14%CE%B1-demethylase" class="mw-redirect" title="Lanosterol 14α-demethylase">Lanosterol 14α-demethylase</a></li> <li><a href="/wiki/Sterol-C5-desaturase-like" title="Sterol-C5-desaturase-like">Sterol-C5-desaturase-like</a></li> <li><a href="/wiki/7-Dehydrocholesterol_reductase" title="7-Dehydrocholesterol reductase">7-Dehydrocholesterol reductase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Desmosterol" title="Desmosterol">Desmosterol</a> path</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/24-Dehydrocholesterol_reductase" title="24-Dehydrocholesterol reductase">24-Dehydrocholesterol reductase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">To <a href="/wiki/Bile_acid" title="Bile acid">Bile acids</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholesterol_7%CE%B1-hydroxylase" class="mw-redirect" title="Cholesterol 7α-hydroxylase">Cholesterol 7α-hydroxylase</a></li> <li><a href="/wiki/CYP27A1" title="CYP27A1">Sterol 27-hydroxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Steroidogenesis" class="mw-redirect" title="Steroidogenesis">Steroidogenesis</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">To <a href="/wiki/Pregnenolone" title="Pregnenolone">pregnenolone</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholesterol_side-chain_cleavage_enzyme" title="Cholesterol side-chain cleavage enzyme">Cholesterol side-chain cleavage</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">To <a href="/wiki/Corticosteroid" title="Corticosteroid">corticosteroids</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Aldosterone" title="Aldosterone">aldosterone</a>:</i> <a href="/wiki/Aldosterone_synthase" title="Aldosterone synthase">18-Hydroxylase</a></li></ul> <ul><li><i><a href="/wiki/Cortisol" title="Cortisol">cortisol</a>/<a href="/wiki/Cortisone" title="Cortisone">cortisone</a>:</i> <a class="mw-selflink selflink">17α-Hydroxylase</a></li> <li><a href="/wiki/11%CE%B2-Hydroxysteroid_dehydrogenase" title="11β-Hydroxysteroid dehydrogenase">11β-<abbr title="Hydroxysteroid dehydrogenase">HSD</abbr></a> <ul><li><a href="/wiki/11%CE%B2-Hydroxysteroid_dehydrogenase_type_1" title="11β-Hydroxysteroid dehydrogenase type 1">1</a></li> <li><a href="/wiki/11%CE%B2-Hydroxysteroid_dehydrogenase_type_2" class="mw-redirect" title="11β-Hydroxysteroid dehydrogenase type 2">2</a></li></ul></li></ul> <ul><li><i>both:</i> <a href="/wiki/3%CE%B2-Hydroxysteroid_dehydrogenase" title="3β-Hydroxysteroid dehydrogenase">3β-<abbr title="Hydroxysteroid dehydrogenase">HSD</abbr></a> <ul><li><a href="/wiki/HSD3B1" title="HSD3B1">1</a></li> <li><a href="/wiki/HSD3B2" title="HSD3B2">2</a></li></ul></li> <li><a href="/wiki/21-Hydroxylase" title="21-Hydroxylase">21-Hydroxylase</a></li> <li><a href="/wiki/11%CE%B2-Hydroxylase" class="mw-redirect" title="11β-Hydroxylase">11β-Hydroxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">To <a href="/wiki/Sex_hormone" title="Sex hormone">sex hormones</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">To <a href="/wiki/Androgen" title="Androgen">androgens</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">17α-Hydroxylase</a></li> <li><a class="mw-selflink selflink">17,20-Lyase</a></li> <li><a href="/wiki/3%CE%B2-Hydroxysteroid_dehydrogenase" title="3β-Hydroxysteroid dehydrogenase">3β-<abbr title="Hydroxysteroid dehydrogenase">HSD</abbr></a></li> <li><a href="/wiki/17%CE%B2-Hydroxysteroid_dehydrogenase" title="17β-Hydroxysteroid dehydrogenase">17β-<abbr title="Hydroxysteroid dehydrogenase">HSD</abbr></a></li> <li><a href="/wiki/5-alpha_reductase" class="mw-redirect" title="5-alpha reductase">5α-Reductase</a> <ul><li><a href="/wiki/SRD5A1" title="SRD5A1">1</a></li> <li><a href="/wiki/SRD5A2" title="SRD5A2">2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">To <a href="/wiki/Estrogen" title="Estrogen">estrogens</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aromatase" title="Aromatase">Aromatase</a></li> <li><a href="/wiki/17%CE%B2-Hydroxysteroid_dehydrogenase" title="17β-Hydroxysteroid dehydrogenase">17β-<abbr title="Hydroxysteroid dehydrogenase">HSD</abbr></a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other/ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Steroid_metabolism" class="mw-redirect" title="Steroid metabolism">Steroid metabolism</a>: <i><a href="/wiki/Sulfatase" title="Sulfatase">sulfatase</a></i> <ul><li><a href="/wiki/Steroid_sulfatase" title="Steroid sulfatase">Steroid sulfatase</a></li></ul></li> <li><i><a href="/wiki/Sulfotransferase" title="Sulfotransferase">sulfotransferase</a></i> <ul><li><a href="/wiki/SULT1A1" title="SULT1A1">SULT1A1</a></li> <li><a href="/wiki/SULT2A1" class="mw-redirect" title="SULT2A1">SULT2A1</a></li></ul></li></ul> <ul><li><a href="/wiki/Steroidogenic_acute_regulatory_protein" title="Steroidogenic acute regulatory protein">Steroidogenic acute regulatory protein</a></li> <li><a href="/wiki/Cholesterol_total_synthesis" title="Cholesterol total synthesis">Cholesterol total synthesis</a></li> <li><a href="/wiki/Reverse_cholesterol_transport" title="Reverse cholesterol transport">Reverse cholesterol transport</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Cytochromes,_oxygenases:_cytochrome_P450_(Most_belong_to_EC_1.14)" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cytochrome_P450" title="Template:Cytochrome P450"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cytochrome_P450" title="Template talk:Cytochrome P450"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cytochrome_P450" title="Special:EditPage/Template:Cytochrome P450"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cytochromes,_oxygenases:_cytochrome_P450_(Most_belong_to_EC_1.14)" style="font-size:114%;margin:0 4em"><a href="/wiki/Cytochrome" title="Cytochrome">Cytochromes</a>, <a href="/wiki/Oxygenase" title="Oxygenase">oxygenases</a>: <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> (Most belong to <a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 1.14)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP1</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP1A1" title="CYP1A1">A1</a></li> <li><a href="/wiki/CYP1A2" title="CYP1A2">A2</a></li> <li><a href="/w/index.php?title=CYP1A5&action=edit&redlink=1" class="new" title="CYP1A5 (page does not exist)">A5</a></li> <li><a href="/wiki/CYP1B1" title="CYP1B1">B1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP2</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP2A6" title="CYP2A6">A6</a></li> <li><a href="/wiki/CYP2A7" title="CYP2A7">A7</a></li> <li><a href="/wiki/CYP2A13" title="CYP2A13">A13</a></li> <li><a href="/wiki/CYP2B6" title="CYP2B6">B6</a></li> <li><a href="/wiki/CYP2C8" title="CYP2C8">C8</a></li> <li><a href="/wiki/CYP2C9" title="CYP2C9">C9</a></li> <li><a href="/wiki/CYP2C18" title="CYP2C18">C18</a></li> <li><a href="/wiki/CYP2C19" title="CYP2C19">C19</a></li> <li><a href="/wiki/CYP2D6" title="CYP2D6">D6</a></li> <li><a href="/wiki/CYP2E1" title="CYP2E1">E1</a></li> <li><a href="/wiki/CYP2F1" title="CYP2F1">F1</a></li> <li><a href="/wiki/CYP2J2" title="CYP2J2">J2</a></li> <li><a href="/wiki/CYP2R1" title="CYP2R1">R1</a></li> <li><a href="/wiki/CYP2S1" title="CYP2S1">S1</a></li> <li><a href="/wiki/CYP2U1" title="CYP2U1">U1</a></li> <li><a href="/wiki/CYP2W1" title="CYP2W1">W1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP3 (<a href="/wiki/CYP3A" title="CYP3A">CYP3A</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP3A4" title="CYP3A4">A4</a></li> <li><a href="/wiki/CYP3A5" title="CYP3A5">A5</a></li> <li><a href="/wiki/CYP3A7" title="CYP3A7">A7</a></li> <li><a href="/w/index.php?title=CYP3A37&action=edit&redlink=1" class="new" title="CYP3A37 (page does not exist)">A37</a></li> <li><a href="/wiki/CYP3A43" title="CYP3A43">A43</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP4</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP4A11" title="CYP4A11">A11</a></li> <li><a href="/wiki/CYP4A22" title="CYP4A22">A22</a></li> <li><a href="/wiki/CYP4B1" title="CYP4B1">B1</a></li> <li><a href="/wiki/CYP4F2" title="CYP4F2">F2</a></li> <li><a href="/wiki/CYP4F3" title="CYP4F3">F3</a></li> <li><a href="/wiki/CYP4F8" title="CYP4F8">F8</a></li> <li><a href="/wiki/CYP4F11" title="CYP4F11">F11</a></li> <li><a href="/wiki/CYP4F12" title="CYP4F12">F12</a></li> <li><a href="/wiki/CYP4F22" title="CYP4F22">F22</a></li> <li><a href="/wiki/CYP4V2" title="CYP4V2">V2</a></li> <li><a href="/wiki/CYP4X1" title="CYP4X1">X1</a></li> <li><a href="/wiki/CYP4Z1" title="CYP4Z1">Z1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP5-20</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>CYP5</i> (<a href="/wiki/Thromboxane-A_synthase" title="Thromboxane-A synthase">A1</a>)</li> <li><i><a href="/wiki/CYP6_family" title="CYP6 family">CYP6</a></i> (<a href="/wiki/CYP6G1" title="CYP6G1">G1</a>, <a href="/wiki/CYP6M2" title="CYP6M2">M2</a>)</li> <li><i>CYP7</i> (<a href="/wiki/Cholesterol_7_alpha-hydroxylase" title="Cholesterol 7 alpha-hydroxylase">A1</a>, <a href="/wiki/CYP7B1" title="CYP7B1">B1</a>)</li> <li><i>CYP8</i> (<a href="/wiki/CYP8A1" class="mw-redirect" title="CYP8A1">A1</a>, <a href="/wiki/CYP8B1" title="CYP8B1">B1</a>)</li> <li><i><a href="/wiki/CYP9_family" title="CYP9 family">CYP9</a></i></li> <li><i><a href="/wiki/CYP10_family" title="CYP10 family">CYP10</a></i></li> <li><i><a href="/wiki/CYP11_family" title="CYP11 family">CYP11</a></i> (<a href="/wiki/Cholesterol_side-chain_cleavage_enzyme" title="Cholesterol side-chain cleavage enzyme">A1</a>, <a href="/wiki/CYP11A2" title="CYP11A2">A2</a>, <a href="/wiki/Steroid_11-beta-hydroxylase" class="mw-redirect" title="Steroid 11-beta-hydroxylase">B1</a>, <a href="/wiki/Aldosterone_synthase" title="Aldosterone synthase">B2</a>, <a href="/wiki/CYP11B3" title="CYP11B3">B3</a>, <a href="/wiki/CYP11C1" title="CYP11C1">C1</a>)</li> <li><i><a href="/wiki/CYP12_family" title="CYP12 family">CYP12</a></i></li> <li><i><a href="/wiki/CYP13_family" title="CYP13 family">CYP13</a></i></li> <li><i><a href="/wiki/CYP14_family" title="CYP14 family">CYP14</a></i></li> <li><i><a href="/wiki/CYP15_family" title="CYP15 family">CYP15</a></i></li> <li><i><a href="/wiki/CYP16_family" title="CYP16 family">CYP16</a></i></li> <li><i>CYP17</i> (<a class="mw-selflink selflink">A1</a>)</li> <li><i><a href="/wiki/CYP18_family" title="CYP18 family">CYP18</a></i></li> <li><i>CYP19</i> (<a href="/wiki/Aromatase" title="Aromatase">A1</a>)</li> <li><i>CYP20</i> (<a href="/wiki/CYP20A1" title="CYP20A1">A1</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP21-49</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>CYP21</i> (<a href="/wiki/21-Hydroxylase" title="21-Hydroxylase">A2</a>)</li> <li><i>CYP22</i> (<a href="/wiki/Daf-9" title="Daf-9">A1</a>)</li> <li><i><a href="/wiki/CYP23_family" title="CYP23 family">CYP23</a></i></li> <li><i>CYP24</i> (<a href="/wiki/CYP24A1" title="CYP24A1">A1</a>)</li> <li><i><a href="/wiki/CYP25_family" title="CYP25 family">CYP25</a></i></li> <li><i><a href="/wiki/CYP26_family" title="CYP26 family">CYP26</a></i> (<a href="/wiki/CYP26A1" title="CYP26A1">A1</a>, <a href="/wiki/CYP26B1" title="CYP26B1">B1</a>, <a href="/wiki/CYP26C1" title="CYP26C1">C1</a>)</li> <li><i><a href="/wiki/CYP27_family" title="CYP27 family">CYP27</a></i> (<a href="/wiki/CYP27A1" title="CYP27A1">A1</a>, <a href="/wiki/25-Hydroxyvitamin_D3_1-alpha-hydroxylase" class="mw-redirect" title="25-Hydroxyvitamin D3 1-alpha-hydroxylase">B1</a>, <a href="/wiki/CYP27C1" title="CYP27C1">C1</a>)</li> <li><i>CYP28</i> (<a href="/wiki/CYP28A1" title="CYP28A1">A1</a>)</li> <li><i><a href="/w/index.php?title=CYP29_family&action=edit&redlink=1" class="new" title="CYP29 family (page does not exist)">CYP29</a></i></li> <li><i>CYP35</i> (<a href="/wiki/CYP35B1" title="CYP35B1">B1</a>)</li> <li><i>CYP39</i> (<a href="/wiki/CYP39A1" title="CYP39A1">A1</a>)</li> <li><i>CYP46</i> (<a href="/wiki/CYP46A1" class="mw-redirect" title="CYP46A1">A1</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP51-69</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Sterol_14-demethylase" title="Sterol 14-demethylase">CYP51</a></i> (<a href="/wiki/Lanosterol_14_alpha-demethylase" title="Lanosterol 14 alpha-demethylase">A1</a>, <a href="/wiki/ERG11" title="ERG11">F1</a>)</li> <li><i><a href="/wiki/CYP52_family" title="CYP52 family">CYP52</a></i></li> <li><i><a href="/wiki/CYP53_family" title="CYP53 family">CYP53</a></i> <ul><li><a href="/wiki/Benzoate_4-monooxygenase" title="Benzoate 4-monooxygenase">A1</a></li></ul></li> <li><i><a href="/wiki/CYP55_family" title="CYP55 family">CYP55</a></i> <ul><li><a href="/wiki/Nitric_oxide_reductase_(NAD(P),_nitrous_oxide-forming)" title="Nitric oxide reductase (NAD(P), nitrous oxide-forming)">A1</a></li></ul></li> <li><i>CYP56</i> <ul><li><a href="/wiki/CYP56A1" title="CYP56A1">A1</a></li></ul></li> <li><i><a href="/wiki/ERG5" title="ERG5">CYP61</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP71-99</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>CYP71</i> (<a href="/wiki/3-hydroxyindolin-2-one_monooxygenase" title="3-hydroxyindolin-2-one monooxygenase">C1</a>, <a href="/wiki/Indolin-2-one_monooxygenase" title="Indolin-2-one monooxygenase">C2</a>, <a href="/wiki/2-Hydroxy-1,4-benzoxazin-3-one_monooxygenase" title="2-Hydroxy-1,4-benzoxazin-3-one monooxygenase">C3</a>, <a href="/wiki/Indole-2-monooxygenase" title="Indole-2-monooxygenase">C4</a>, <a href="/wiki/Ent-isokaurene_C2-hydroxylase" title="Ent-isokaurene C2-hydroxylase">Z6</a>, <a href="/wiki/Angelicin_synthase" title="Angelicin synthase">AJ4</a>, <a href="/wiki/Amorpha-4,11-diene_12-monooxygenase" title="Amorpha-4,11-diene 12-monooxygenase">AV1</a>, <a href="/wiki/Alpha-humulene_10-hydroxylase" title="Alpha-humulene 10-hydroxylase">BA1</a>)</li> <li><i><a href="/wiki/Secologanin_synthase" title="Secologanin synthase">CYP72A1</a></i></li> <li><i><a href="/wiki/Trans-cinnamate_4-monooxygenase" title="Trans-cinnamate 4-monooxygenase">CYP73A1</a></i></li> <li><i><a href="/wiki/CYP74_family" title="CYP74 family">CYP74</a></i> (<a href="/wiki/Colneleate_synthase" title="Colneleate synthase">D1</a>)</li> <li><i>CYP75</i> (<a href="/wiki/Flavonoid_3%27,5%27-hydroxylase" title="Flavonoid 3',5'-hydroxylase">A1</a>, <a href="/wiki/Flavonoid_3%27-monooxygenase" title="Flavonoid 3'-monooxygenase">B1</a>)</li> <li><i><a href="/wiki/CYP76_family" title="CYP76 family">CYP76</a></i> (<a href="/wiki/Geraniol_8-hydroxylase" title="Geraniol 8-hydroxylase">B6</a>, <a href="/wiki/Ent-cassa-12,15-diene_11-hydroxylase" title="Ent-cassa-12,15-diene 11-hydroxylase">M7</a>)</li> <li><i>CYP79</i> (<a href="/wiki/Tyrosine_N-monooxygenase" title="Tyrosine N-monooxygenase">A1</a>, <a href="/wiki/Phenylalanine_N-monooxygenase" title="Phenylalanine N-monooxygenase">A2</a>, <a href="/wiki/Tryptophan_N-monooxygenase" title="Tryptophan N-monooxygenase">B1</a>, <a href="/wiki/Tryptophan_N-monooxygenase" title="Tryptophan N-monooxygenase">B2</a>, <a href="/wiki/Tryptophan_N-monooxygenase" title="Tryptophan N-monooxygenase">B3</a>, <a href="/wiki/Valine_N-monooxygenase" title="Valine N-monooxygenase">D1</a>, <a href="/wiki/Valine_N-monooxygenase" title="Valine N-monooxygenase">D2</a>, <a href="/wiki/Isoleucine_N-monooxygenase" title="Isoleucine N-monooxygenase">D3</a>, <a href="/wiki/Isoleucine_N-monooxygenase" title="Isoleucine N-monooxygenase">D4</a>)</li> <li><i>CYP80</i> (<a href="/wiki/Berbamunine_synthase" title="Berbamunine synthase">A1</a>, <a href="/wiki/N-methylcoclaurine_3%27-monooxygenase" title="N-methylcoclaurine 3'-monooxygenase">B1</a>, <a href="/wiki/(S)-corytuberine_synthase" title="(S)-corytuberine synthase">G2</a>)</li> <li><i>CYP81</i> (<a href="/wiki/Isoflavone_2%27-hydroxylase" title="Isoflavone 2'-hydroxylase">E1</a>, <a href="/wiki/4%27-methoxyisoflavone_2%27-hydroxylase" title="4'-methoxyisoflavone 2'-hydroxylase">E3</a>, <a href="/wiki/4%27-methoxyisoflavone_2%27-hydroxylase" title="4'-methoxyisoflavone 2'-hydroxylase">E7</a>, <a href="/wiki/Isoflavone_3%27-hydroxylase" title="Isoflavone 3'-hydroxylase">E9</a>)</li> <li><i><a href="/wiki/Beta-amyrin_11-oxidase" title="Beta-amyrin 11-oxidase">CYP88D6</a></i></li> <li><i><a href="/wiki/3-Epi-6-deoxocathasterone_23-monooxygenase" title="3-Epi-6-deoxocathasterone 23-monooxygenase">CYP90C1</a></i></li> <li><i><a href="/wiki/Beta-amyrin_24-hydroxylase" title="Beta-amyrin 24-hydroxylase">CYP93E1</a></i></li> <li><i><a href="/wiki/Carotene_epsilon-monooxygenase" title="Carotene epsilon-monooxygenase">CYP97C1</a></i></li> <li><i><a href="/wiki/9beta-pimara-7,15-diene_oxidase" title="9beta-pimara-7,15-diene oxidase">CYP99A3</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP101-281</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Camphor_5-monooxygenase" title="Camphor 5-monooxygenase">CYP101A1</a></i></li> <li><i><a href="/wiki/Cytochrome_P450_BM3" title="Cytochrome P450 BM3">CYP102A1</a></i></li> <li><i><a href="/wiki/CYP105_family" title="CYP105 family">CYP105</a></i> <ul><li><a href="/wiki/Vitamin_D3_dihydroxylase" title="Vitamin D3 dihydroxylase">A1</a></li> <li><a href="/wiki/Pentalenic_acid_synthase" title="Pentalenic acid synthase">D7</a></li></ul></li> <li><i><a href="/wiki/Steroid_15beta-monooxygenase" title="Steroid 15beta-monooxygenase">CYP106A2</a></i></li> <li><i><a href="/wiki/CYP107_family" title="CYP107 family">CYP107</a></i> <ul><li><a href="/wiki/Cytochrome_P450_eryF" title="Cytochrome P450 eryF">A1</a></li> <li><a href="/wiki/CYP107G1" title="CYP107G1">G1</a></li></ul></li> <li><i><a href="/wiki/CYP109_family" title="CYP109 family">CYP109</a></i> <ul><li><a href="/wiki/CYP109B1" title="CYP109B1">B1</a></li> <li><a href="/wiki/CYP109E1" title="CYP109E1">E1</a></li></ul></li> <li><i><a href="/wiki/Linalool_8-monooxygenase" title="Linalool 8-monooxygenase">CYP111</a></i></li> <li><i><a href="/wiki/Erythromycin_12_hydroxylase" title="Erythromycin 12 hydroxylase">CYP113A1</a></i></li> <li><i><a href="/wiki/CYP119A1" title="CYP119A1">CYP119A1</a></i></li> <li><i><a href="/wiki/CYP123_family" title="CYP123 family">CYP123</a></i></li> <li><i><a href="/wiki/Cholest-4-en-3-one_26-monooxygenase" title="Cholest-4-en-3-one 26-monooxygenase">CYP125A1</a></i></li> <li><i><a href="/wiki/CYP139_family" title="CYP139 family">CYP139</a></i></li> <li><i><a href="/wiki/CYP147_family" title="CYP147 family">CYP147</a></i></li> <li><i><a href="/wiki/Fatty-acid_peroxygenase" title="Fatty-acid peroxygenase">CYP152</a></i> <ul><li>A1</li> <li>B1</li></ul></li> <li><i><a href="/wiki/CYP154C3" title="CYP154C3">CYP154C3</a></i></li> <li><i><a href="/wiki/Biflaviolin_synthase" title="Biflaviolin synthase">CYP158A</a></i></li> <li><i><a href="/wiki/Pentalenolactone_synthase" title="Pentalenolactone synthase">CYP161C</a></i></li> <li><i>CYP170</i> <ul><li><i><a href="/wiki/Epi-isozizaene_5-monooxygenase" title="Epi-isozizaene 5-monooxygenase">A1</a></i></li> <li><i><a href="/wiki/CYP170B1" title="CYP170B1">B1</a></i></li></ul></li> <li><i><a href="/wiki/1,8-Cineole_2-endo-monooxygenase" title="1,8-Cineole 2-endo-monooxygenase">CYP176A1</a></i></li> <li><i><a href="/wiki/Pentalenene_oxygenase" title="Pentalenene oxygenase">CYP183A</a></i></li> <li><i><a href="/wiki/CYP197_family" title="CYP197 family">CYP197</a></i></li> <li><i><a href="/wiki/4-methoxybenzoate_monooxygenase_(O-demethylating)" title="4-methoxybenzoate monooxygenase (O-demethylating)">CYP199A2</a></i></li> <li><i><a href="/wiki/Cytochrome_P450_aromatic_O-demethylase" title="Cytochrome P450 aromatic O-demethylase">CYP255A</a> </i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP301-499</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/CYP303A1" title="CYP303A1">CYP303A1</a></i></li> <li><i><a href="/wiki/CYP305_family" title="CYP305 family">CYP305</a></i> <ul><li><a href="/wiki/CYP305M2" title="CYP305M2">M2</a></li></ul></li> <li><a href="/wiki/Halloween_genes" title="Halloween genes">Halloween genes</a> ( <i>CYP302A1</i>, <i>CYP306A1</i>, <i>CYP307A1</i>, <i>CYP307A2</i>, <i><a href="/wiki/Ecdysone_20-monooxygenase" title="Ecdysone 20-monooxygenase">CYP314A1</a></i>, <i>CYP315A1</i>)</li> <li><i><a href="/wiki/CYP318A1" title="CYP318A1">CYP318A1</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP501-699</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Ent-kaurene_oxidase" title="Ent-kaurene oxidase">CYP503</a></i></li> <li><i><a href="/wiki/3-hydroxyphenylacetate_6-hydroxylase" title="3-hydroxyphenylacetate 6-hydroxylase">CYP504B1</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP701-999</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/CYP704B22" class="mw-redirect" title="CYP704B22">CYP704B22</a></i></li> <li><i><a href="/wiki/CYP710_family" title="CYP710 family">CYP710</a></i></li> <li><i><a href="/wiki/Abietadienol_hydroxylase" title="Abietadienol hydroxylase">CYP720A1</a></i></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Oxidoreductases:_dioxygenases,_including_steroid_hydroxylases_(EC_1.14)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Dioxygenases" title="Template:Dioxygenases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Dioxygenases" title="Template talk:Dioxygenases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Dioxygenases" title="Special:EditPage/Template:Dioxygenases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Oxidoreductases:_dioxygenases,_including_steroid_hydroxylases_(EC_1.14)" style="font-size:114%;margin:0 4em"><a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a>: <a href="/wiki/Oxygenase" title="Oxygenase">dioxygenases</a>, including <a href="/wiki/Steroid_hydroxylases" class="mw-redirect" title="Steroid hydroxylases">steroid hydroxylases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 1.14)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.11_With_2-oxoglutarate_as_one_donor.2C_and_incorporation_of_one_atom_each_of_oxygen_into_both_donors" title="List of EC numbers (EC 1)">1.14.11</a>: <a href="/wiki/Alpha-Ketoglutaric_acid" class="mw-redirect" title="Alpha-Ketoglutaric acid">2-oxoglutarate</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Prolyl_hydroxylase" class="mw-redirect" title="Prolyl hydroxylase">Prolyl hydroxylase</a> <ul><li><a href="/wiki/HIF_prolyl-hydroxylase" class="mw-redirect" title="HIF prolyl-hydroxylase">HIF prolyl-hydroxylase</a> <ul><li><a href="/wiki/EGLN1" title="EGLN1">EGLN1</a></li> <li><a href="/wiki/EGLN2" title="EGLN2">EGLN2</a></li> <li><a href="/wiki/EGLN3" title="EGLN3">EGLN3</a></li></ul></li> <li><a href="/wiki/P4HTM" title="P4HTM">P4HTM</a></li></ul></li> <li><a href="/wiki/Lysyl_hydroxylase" title="Lysyl hydroxylase">Lysyl hydroxylase</a></li> <li><a href="/wiki/AlkB" title="AlkB">AlkB</a> <ul><li><a href="/wiki/Alkb_homolog_1,_histone_h2a_dioxygenase" title="Alkb homolog 1, histone h2a dioxygenase">ALKBH1</a></li> <li><a href="/wiki/FTO_gene" title="FTO gene">FTO</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.13_With_NADH_or_NADPH_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.13</a>: <a href="/wiki/NADH" class="mw-redirect" title="NADH">NADH</a> or <a href="/wiki/NADPH" class="mw-redirect" title="NADPH">NADPH</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Flavin-containing_monooxygenase" title="Flavin-containing monooxygenase">Flavin-containing monooxygenase</a> <ul><li><a href="/wiki/FMO1" class="mw-redirect" title="FMO1">FMO1</a></li> <li><a href="/wiki/FMO2" title="FMO2">FMO2</a></li> <li><a href="/wiki/Flavin-containing_monooxygenase_3" title="Flavin-containing monooxygenase 3">FMO3</a></li> <li><a href="/wiki/FMO4" title="FMO4">FMO4</a></li> <li><a href="/wiki/FMO5" title="FMO5">FMO5</a></li></ul></li> <li><a href="/wiki/Nitric_oxide_synthase" title="Nitric oxide synthase">Nitric oxide synthase</a> <ul><li><a href="/wiki/NOS1" title="NOS1">NOS1</a></li> <li><a href="/wiki/Nitric_oxide_synthase_2_(inducible)" title="Nitric oxide synthase 2 (inducible)">NOS2</a></li> <li><a href="/wiki/Endothelial_NOS" title="Endothelial NOS">NOS3</a></li></ul></li> <li><a href="/wiki/Cholesterol_7_alpha-hydroxylase" title="Cholesterol 7 alpha-hydroxylase">Cholesterol 7 alpha-hydroxylase</a></li> <li><a href="/wiki/Methane_monooxygenase" title="Methane monooxygenase">Methane monooxygenase</a></li> <li><a href="/wiki/CYP3A4" title="CYP3A4">3A4</a></li> <li><a href="/wiki/14%CE%B1-demethylase" class="mw-redirect" title="14α-demethylase">14α-demethylase</a></li> <li><a href="/wiki/24-hydroxycholesterol_7alpha-hydroxylase" title="24-hydroxycholesterol 7alpha-hydroxylase">24-hydroxycholesterol 7α-hydroxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.14_With_reduced_flavin_or_flavoprotein_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.14</a>: reduced <a href="/wiki/Flavin_group" title="Flavin group">flavin</a> or <a href="/wiki/Flavoprotein" title="Flavoprotein">flavoprotein</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aromatase" title="Aromatase">19A1</a></li> <li><a href="/wiki/CYP2D6" title="CYP2D6">2D6</a></li> <li><a href="/wiki/CYP2E1" title="CYP2E1">2E1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.15_With_reduced_iron–sulfur_protein_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.15</a>: reduced <a href="/wiki/Iron%E2%80%93sulfur_protein" title="Iron–sulfur protein">iron–sulfur protein</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Steroid_11-beta-hydroxylase" class="mw-redirect" title="Steroid 11-beta-hydroxylase">11B1</a></li> <li><a href="/wiki/Aldosterone_synthase" title="Aldosterone synthase">11B2</a></li> <li><a href="/wiki/Cholesterol_side-chain_cleavage_enzyme" title="Cholesterol side-chain cleavage enzyme">11A1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.16_With_reduced_pteridine_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.16</a>: reduced <a href="/wiki/Pteridine" title="Pteridine">pteridine</a> (<a href="/wiki/Tetrahydrobiopterin" title="Tetrahydrobiopterin">BH4 dependent</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Phenylalanine_hydroxylase" title="Phenylalanine hydroxylase">Phenylalanine hydroxylase</a></li> <li><a href="/wiki/Tyrosine_hydroxylase" title="Tyrosine hydroxylase">Tyrosine hydroxylase</a></li> <li><a href="/wiki/Tryptophan_hydroxylase" title="Tryptophan hydroxylase">Tryptophan hydroxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.17_With_reduced_ascorbate_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.17</a>: reduced <a href="/wiki/Ascorbate" class="mw-redirect" title="Ascorbate">ascorbate</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dopamine_beta-hydroxylase" title="Dopamine beta-hydroxylase">Dopamine beta-hydroxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.18_With_another_compound_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.18</a>-<a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.19_With_oxidation_of_a_pair_of_donors_resulting_in_the_reduction_of_molecular_oxygen_to_two_molecules_of_water" title="List of EC numbers (EC 1)">19</a>: other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tyrosinase" title="Tyrosinase">Tyrosinase</a></li> <li><a href="/wiki/Stearoyl-CoA_desaturase-1" class="mw-redirect" title="Stearoyl-CoA desaturase-1">Stearoyl-CoA desaturase-1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.99_Miscellaneous" title="List of EC numbers (EC 1)">1.14.99</a> - miscellaneous</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cyclooxygenase" title="Cyclooxygenase">Cyclooxygenase</a></li> <li><a href="/wiki/Heme_oxygenase" title="Heme oxygenase">Heme oxygenase</a> (<a href="/wiki/HMOX1" title="HMOX1">HMOX1</a>)</li> <li><a href="/wiki/Squalene_monooxygenase" title="Squalene monooxygenase">Squalene monooxygenase</a></li> <li><a class="mw-selflink selflink">17A1</a></li> <li><a href="/wiki/21-Hydroxylase" title="21-Hydroxylase">21A2</a></li> <li><a href="/wiki/Ecdysone_20-monooxygenase" title="Ecdysone 20-monooxygenase">Ecdysone 20-monooxygenase</a></li> <li><a href="/wiki/Deoxyhypusine_monooxygenase" title="Deoxyhypusine monooxygenase">Deoxyhypusine monooxygenase</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=CYP17A1&oldid=1240034219">https://en.wikipedia.org/w/index.php?title=CYP17A1&oldid=1240034219</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div 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