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Flutemetamol (18F) - Wikipedia

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id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Chemical compound</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Flutemetamol (&lt;sup&gt;18&lt;/sup&gt;F)">Flutemetamol (<sup>18</sup>F)</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Flutemetamol_(18F).svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4d/Flutemetamol_%2818F%29.svg/220px-Flutemetamol_%2818F%29.svg.png" decoding="async" width="220" height="81" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4d/Flutemetamol_%2818F%29.svg/330px-Flutemetamol_%2818F%29.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4d/Flutemetamol_%2818F%29.svg/440px-Flutemetamol_%2818F%29.svg.png 2x" data-file-width="484" data-file-height="178" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Vizamyl</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/cons/flutemetamol-f-18-intravenous.html">Micromedex Detailed Consumer Information</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small>&#160;<a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>:&#160;<span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&amp;query=Flutemetamol">Flutemetamol</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous">Intravenous</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_V09" title="ATC code V09">V09AX04</a>&#x20;(<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=V09AX04">WHO</a></span>)&#x20;</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr>:</small>&#x20;<a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a></li> <li><small><abbr class="country-name" title="European Union">EU</abbr>:</small>&#x20;Rx-only<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup></li> <li>In&#160;general: ℞&#160;(Prescription only)</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">2-[3-(<sup>18</sup>F)Fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=765922-62-1">765922-62-1</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/15950376">15950376</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.13092196.html">13092196</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/L49M066S0O">L49M066S0O</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D10231">D10231</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:76611">CHEBI:76611</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID80227394">DTXSID80227394</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q18355673#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data">C<sub>14</sub>H<sub>11</sub><sup>18</sup>FN<sub>2</sub>OS</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data">273.316&#x20;g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CNC1%3DC%28C%3DC%28C%3DC1%29C2%3DNC3%3DC%28S2%29C%3DC%28C%3DC3%29O%29%5B18F%5D">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">CNC1=C(C=C(C=C1)C2=NC3=C(S2)C=C(C=C3)O)[18F]</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C14H11FN2OS/c1-16-11-4-2-8(6-10(11)15)14-17-12-5-3-9(18)7-13(12)19-14/h2-7,16,18H,1H3/i15-1</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:VVECGOCJFKTUAX-HUYCHCPVSA-N</div></li></ul> </div></td></tr></tbody></table> <p><b>Flutemetamol (<sup>18</sup>F)</b> (trade name <b>Vizamyl</b>, by <a href="/wiki/GE_Healthcare" class="mw-redirect" title="GE Healthcare">GE Healthcare</a>) is a <a href="/wiki/PET_scan" class="mw-redirect" title="PET scan">PET scanning</a> <a href="/wiki/Radiopharmaceutical" title="Radiopharmaceutical">radiopharmaceutical</a> containing the radionuclide <a href="/wiki/Fluorine-18" title="Fluorine-18">fluorine-18</a>, used as a diagnostic tool for <a href="/wiki/Alzheimer%27s_disease" title="Alzheimer&#39;s disease">Alzheimer's disease</a>.<sup id="cite_ref-Spreitzer_2-0" class="reference"><a href="#cite_note-Spreitzer-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Adverse_effects">Adverse effects</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Flutemetamol_(18F)&amp;action=edit&amp;section=1" title="Edit section: Adverse effects"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Adverse effects of flutemetamol include headache, <a href="/wiki/Nausea" title="Nausea">nausea</a>, dizziness, flushing and increased blood pressure.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Mechanism_of_action">Mechanism of action</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Flutemetamol_(18F)&amp;action=edit&amp;section=2" title="Edit section: Mechanism of action"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>After the substance is given <a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous">intravenously</a>, it accumulates in <a href="/wiki/Beta_amyloid" class="mw-redirect" title="Beta amyloid">beta amyloid</a> plaques in the patient's brain, which thus become visible via positron emission tomography (PET).<sup id="cite_ref-Spreitzer_2-1" class="reference"><a href="#cite_note-Spreitzer-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Manufacturing_and_distribution">Manufacturing and distribution</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Flutemetamol_(18F)&amp;action=edit&amp;section=3" title="Edit section: Manufacturing and distribution"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Flutemetamol (<sup>18</sup>F) can be produced within five to six hours. It then undergoes a quality check and is ready to be distributed immediately after. The product must be used within a certain time frame for maximum efficacy. Because of the limited time window, flutemetamol is not produced until an order has been placed.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> </p><p>Flutemetamol is typically administered <a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous">intravenously</a> in 1 to 10&#160;mL doses.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> Average costs for PET scans without insurance coverage are around $3,000. Currently <a href="/wiki/Medicare_(United_States)" title="Medicare (United States)">Medicare</a> does not cover use of amyloid imaging agents except for in clinical trials.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> Because of this, there is a low market for flutemetamol. </p> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Flutemetamol_(18F)&amp;action=edit&amp;section=4" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Flutemetamol was first approved for use in the US by the <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) in 2013 for intravenous use.<sup id="cite_ref-:0_7-0" class="reference"><a href="#cite_note-:0-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Clinical_trials">Clinical trials</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Flutemetamol_(18F)&amp;action=edit&amp;section=5" title="Edit section: Clinical trials"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Two clinical trials were conducted for flutemetamol (<sup>18</sup>F). The first compared PET scans of terminally ill patients with flutemetamol to <a href="/wiki/Post_mortem" class="mw-redirect" title="Post mortem">post mortem</a> standard-of-truth assessments of cerebral cortical <a href="/wiki/Neuritic_plaque" class="mw-redirect" title="Neuritic plaque">neuritic plaque</a> density. The second trial assessed intra-reader reproducibility of PET scans using flutemetamol.<sup id="cite_ref-:1_8-0" class="reference"><a href="#cite_note-:1-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Clinical_trial_1">Clinical trial 1</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Flutemetamol_(18F)&amp;action=edit&amp;section=6" title="Edit section: Clinical trial 1"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Of the 176 patients imaged in this trial had a median age was 82, with 57 of patients being female. The initial flutemetamol PET scan resulted in 43 positive and 25 negative results for cerebral cortisol amyloid status. 69 of the initial patients died within 13 months of the flutemetamol PET scan. The autopsy for 67 of those patients determined the global brain neuritic plaque density category. Of those 67 patients 41 were positive and 26 were negative.<sup id="cite_ref-:0_7-1" class="reference"><a href="#cite_note-:0-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup> These results correlate with the pre-mortem scan. </p> <div class="mw-heading mw-heading4"><h4 id="Clinical_trial_2">Clinical trial 2</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Flutemetamol_(18F)&amp;action=edit&amp;section=7" title="Edit section: Clinical trial 2"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The second clinical trial included 276 subjects with a median age of 72. The trial measured the effectiveness of an electronic training program for flutemetamol image interpretation using PET scans from trial 1 among other subjects with a variety of cognitive impairment. Final results met the pre-specified success rate with a <a href="/wiki/Fleiss%27_kappa_statistic" class="mw-redirect" title="Fleiss&#39; kappa statistic">Fleiss' kappa statistic</a> of 0.83.<sup id="cite_ref-:0_7-2" class="reference"><a href="#cite_note-:0-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Flutemetamol_(18F)&amp;action=edit&amp;section=8" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/medicines/human/EPAR/vizamyl">"Vizamyl EPAR"</a>. <i>European Medicines Agency</i>. 22 August 2014<span class="reference-accessdate">. Retrieved <span class="nowrap">29 June</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=European+Medicines+Agency&amp;rft.atitle=Vizamyl+EPAR&amp;rft.date=2014-08-22&amp;rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fmedicines%2Fhuman%2FEPAR%2Fvizamyl&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AFlutemetamol+%2818F%29" class="Z3988"></span></span> </li> <li id="cite_note-Spreitzer-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-Spreitzer_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Spreitzer_2-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSpreitzer2014" class="citation journal cs1 cs1-prop-foreign-lang-source">Spreitzer H (18 August 2014). "Neue Wirkstoffe – Flutemetamol". <i>Österreichische Apothekerzeitung</i> (in German) (17/2014): 43.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=%C3%96sterreichische+Apothekerzeitung&amp;rft.atitle=Neue+Wirkstoffe+%E2%80%93+Flutemetamol&amp;rft.issue=17%2F2014&amp;rft.pages=43&amp;rft.date=2014-08-18&amp;rft.aulast=Spreitzer&amp;rft.aufirst=H&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AFlutemetamol+%2818F%29" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm372261.htm">"FDA Press Release"</a>. <i>FDA</i><span class="reference-accessdate">. Retrieved <span class="nowrap">17 November</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=FDA&amp;rft.atitle=FDA+Press+Release&amp;rft_id=https%3A%2F%2Fwww.fda.gov%2FNewsEvents%2FNewsroom%2FPressAnnouncements%2Fucm372261.htm&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AFlutemetamol+%2818F%29" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20161121175114/http://www.gevizamyl.com/us/about/manufacturing-and-distribution/">"Manufacturing and Distribution | Vizamyl (Flutemetamol F 18 Injection)"</a>. <i>www.gevizamyl.com</i>. Archived from <a rel="nofollow" class="external text" href="http://www.gevizamyl.com/us/about/manufacturing-and-distribution/">the original</a> on 21 November 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">21 November</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=www.gevizamyl.com&amp;rft.atitle=Manufacturing+and+Distribution+%7C+Vizamyl+%28Flutemetamol+F+18+Injection%29&amp;rft_id=http%3A%2F%2Fwww.gevizamyl.com%2Fus%2Fabout%2Fmanufacturing-and-distribution%2F&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AFlutemetamol+%2818F%29" class="Z3988"></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20150226105051/http://www3.gehealthcare.co.uk/en-gb/products/categories/nuclear_imaging_agents/vizamyl#tabs/tab3E9C0BE2F0854E419605207DDF87001C">"Life Sciences Content Alert"</a>. <i>www3.gehealthcare.co.uk</i>. Archived from <a rel="nofollow" class="external text" href="http://www3.gehealthcare.co.uk/en-gb/products/categories/nuclear_imaging_agents/vizamyl#tabs/tab3E9C0BE2F0854E419605207DDF87001C">the original</a> on 26 February 2015<span class="reference-accessdate">. Retrieved <span class="nowrap">21 November</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=www3.gehealthcare.co.uk&amp;rft.atitle=Life+Sciences+Content+Alert&amp;rft_id=http%3A%2F%2Fwww3.gehealthcare.co.uk%2Fen-gb%2Fproducts%2Fcategories%2Fnuclear_imaging_agents%2Fvizamyl%23tabs%2Ftab3E9C0BE2F0854E419605207DDF87001C&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AFlutemetamol+%2818F%29" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20170216160102/http://www.alz.org/documents_custom/hcp_faq_auc.pdf">"Alzheimer's Association"</a> <span class="cs1-format">(PDF)</span>. Archived from <a rel="nofollow" class="external text" href="http://www.alz.org/documents_custom/hcp_faq_auc.pdf">the original</a> <span class="cs1-format">(PDF)</span> on 16 February 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">20 November</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Alzheimer%27s+Association&amp;rft_id=http%3A%2F%2Fwww.alz.org%2Fdocuments_custom%2Fhcp_faq_auc.pdf&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AFlutemetamol+%2818F%29" class="Z3988"></span></span> </li> <li id="cite_note-:0-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-:0_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:0_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:0_7-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20170216155931/http://www.gevizamyl.com/us/wp-content/uploads/2016/06/Vizamyl-43-1067B-04_25_16_PI-3.pdf">"GE Vizamyl"</a> <span class="cs1-format">(PDF)</span>. <i>gevizamyl</i>. Archived from <a rel="nofollow" class="external text" href="http://www.gevizamyl.com/us/wp-content/uploads/2016/06/Vizamyl-43-1067B-04_25_16_PI-3.pdf">the original</a> <span class="cs1-format">(PDF)</span> on 16 February 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">20 November</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=gevizamyl&amp;rft.atitle=GE+Vizamyl&amp;rft_id=http%3A%2F%2Fwww.gevizamyl.com%2Fus%2Fwp-content%2Fuploads%2F2016%2F06%2FVizamyl-43-1067B-04_25_16_PI-3.pdf&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AFlutemetamol+%2818F%29" class="Z3988"></span></span> </li> <li id="cite_note-:1-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-:1_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20161121175118/http://www.gevizamyl.com/us/about/efficacy-and-safety/">"Efficacy and Safety | Vizamyl (Flutemetamol F 18 Injection)"</a>. <i>www.gevizamyl.com</i>. Archived from <a rel="nofollow" class="external text" href="http://www.gevizamyl.com/us/about/efficacy-and-safety/">the original</a> on 21 November 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">20 November</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=www.gevizamyl.com&amp;rft.atitle=Efficacy+and+Safety+%7C+Vizamyl+%28Flutemetamol+F+18+Injection%29&amp;rft_id=http%3A%2F%2Fwww.gevizamyl.com%2Fus%2Fabout%2Fefficacy-and-safety%2F&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AFlutemetamol+%2818F%29" class="Z3988"></span></span> </li> </ol></div></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl 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href="/wiki/Template:Diagnostic_radiopharmaceuticals" title="Template:Diagnostic radiopharmaceuticals"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Diagnostic_radiopharmaceuticals" title="Template talk:Diagnostic radiopharmaceuticals"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Diagnostic_radiopharmaceuticals" title="Special:EditPage/Template:Diagnostic radiopharmaceuticals"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Diagnostic_radiopharmaceuticals_(V09)" style="font-size:114%;margin:0 4em">Diagnostic <a href="/wiki/Radiopharmacology" title="Radiopharmacology">radiopharmaceuticals</a> (<a href="/wiki/ATC_code_V09" title="ATC code V09">V09</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Central_nervous_system" title="Central nervous system">Central nervous system</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_exametazime" title="Technetium (99mTc) exametazime">Exametazime</a>, <a href="/wiki/Technetium_(99mTc)_pentetic_acid" title="Technetium (99mTc) pentetic acid">Pentetic acid</a>)</li> <li><a href="/wiki/Iodine-123" title="Iodine-123"><sup>123</sup>I</a> (<a href="/wiki/Ioflupane_(123I)" title="Ioflupane (123I)">Ioflupane (123I)</a></li> <li><a href="/wiki/Iofetamine_(123I)" title="Iofetamine (123I)">Iofetamine (123I)</a></li> <li><a href="/wiki/Iolopride_(123I)" class="mw-redirect" title="Iolopride (123I)">Iolopride (123I)</a></li> <li><a href="/wiki/Iomazenil_(123I)" class="mw-redirect" title="Iomazenil (123I)">Iomazenil</a>)</li> <li><a href="/wiki/Fluorine-18" title="Fluorine-18"><sup>18</sup>F</a> (<a href="/wiki/Florbetapir_(18F)" title="Florbetapir (18F)">Florbetapir (18F)</a>, <a class="mw-selflink selflink">Flutemetamol (18F)</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Skeletal_system" class="mw-redirect" title="Skeletal system">Skeletal system</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_medronic_acid" title="Technetium (99mTc) medronic acid">Medronic acid</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Renal" class="mw-redirect" title="Renal">Renal</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Iodine-123" title="Iodine-123"><sup>123</sup>I</a> (<a href="/wiki/Sodium_iodohippurate" class="mw-redirect" title="Sodium iodohippurate">Sodium iodohippurate</a>)</li> <li><a href="/wiki/Copper-64" title="Copper-64"><sup>64</sup>Cu</a> <ul><li><a href="/wiki/ETS2" title="ETS2">ETS2</a></li></ul></li> <li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_mertiatide" title="Technetium (99mTc) mertiatide">Mertiatide</a>, <a href="/wiki/Technetium_(99mTc)_pentetic_acid" title="Technetium (99mTc) pentetic acid">Pentetic acid</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Gastrointestinal" class="mw-redirect" title="Gastrointestinal">Gastrointestinal</a>/<a href="/wiki/Hepatic" class="mw-redirect" title="Hepatic">Hepatic</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Selenium-75" class="mw-redirect" title="Selenium-75"><sup>75</sup>Se</a> (<a href="/wiki/SeHCAT" title="SeHCAT">SeHCAT</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Respiratory_system" title="Respiratory system">Respiratory system</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Xenon-133" class="mw-redirect" title="Xenon-133"><sup>133</sup>Xe</a></li> <li><a href="/wiki/Krypton-81m" class="mw-redirect" title="Krypton-81m"><sup>81m</sup>Kr</a></li> <li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_albumin_aggregated" title="Technetium (99mTc) albumin aggregated"><sup>99m</sup>Tc-MAA</a>, <a href="/wiki/Technetium_(99mTc)_pentetic_acid" title="Technetium (99mTc) pentetic acid">Pentetic acid</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Circulatory_system" title="Circulatory system">Cardiovascular system</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_sestamibi" title="Technetium (99mTc) sestamibi">Sestamibi</a></li> <li><a href="/wiki/Technetium_(99mTc)_tetrofosmin" title="Technetium (99mTc) tetrofosmin">Tetrofosmin</a>)</li> <li><a href="/wiki/Indium-111" title="Indium-111"><sup>111</sup>In</a> (<a href="/wiki/Indium_(111In)_imciromab" title="Indium (111In) imciromab">Imciromab</a>)</li> <li><a href="/wiki/Rubidium-82" title="Rubidium-82"><sup>82</sup>Rb</a> (<a href="/wiki/Rubidium-82_chloride" title="Rubidium-82 chloride">Rubidium chloride</a>)</li> <li><a href="/wiki/Iodine-125" title="Iodine-125"><sup>125</sup>I</a> (<a href="/wiki/Iodine_(125I)_human_albumin" title="Iodine (125I) human albumin">Iodinated human albumin</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Inflammation" title="Inflammation">Inflammation</a>/<a href="/wiki/Infection" title="Infection">infection</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_exametazime" title="Technetium (99mTc) exametazime">Exametazime</a></li> <li><a href="/wiki/Technetium_(99mTc)_sulesomab" title="Technetium (99mTc) sulesomab">Sulesomab</a></li> <li><a href="/wiki/Technetium_(99mTc)_tilmanocept" title="Technetium (99mTc) tilmanocept">Tilmanocept</a>)</li> <li><a href="/wiki/Indium-111" title="Indium-111"><sup>111</sup>In</a></li> <li><a href="/wiki/Gallium-67" class="mw-redirect" title="Gallium-67"><sup>67</sup>Ga</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tumor" class="mw-redirect" title="Tumor">Tumor</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> <ul><li><a href="/wiki/Technetium_(99mTc)_arcitumomab" title="Technetium (99mTc) arcitumomab">Arcitumomab</a></li> <li><a href="/wiki/Technetium_(99mTc)_votumumab" title="Technetium (99mTc) votumumab">Votumumab</a></li> <li><a href="/wiki/Technetium_(99mTc)_hynic-octreotide" class="mw-redirect" title="Technetium (99mTc) hynic-octreotide">Hynic-octreotide</a></li></ul></li> <li><a href="/wiki/Indium-111" title="Indium-111"><sup>111</sup>In</a> <ul><li><a href="/wiki/Indium_(111In)_capromab_pendetide" title="Indium (111In) capromab pendetide">Capromab pendetide</a></li> <li><a href="/wiki/Indium_(111In)_satumomab_pendetide" title="Indium (111In) satumomab pendetide">Satumomab pendetide</a></li></ul></li> <li><a href="/wiki/Iodine-125" title="Iodine-125"><sup>125</sup>I</a><span class="nowrap">&#160;</span>(<a href="/wiki/Iodine_(125I)_minretumomab" class="mw-redirect" title="Iodine (125I) minretumomab">Minretumomab</a>)</li> <li><a href="/wiki/Iodine-123" title="Iodine-123"><sup>123</sup>I</a><span class="nowrap">&#160;</span>(<a href="/wiki/Iobenguane" title="Iobenguane">Iobenguane (123I)</a>)</li> <li><a href="/wiki/Iodine-131" title="Iodine-131"><sup>131</sup>I</a><span class="nowrap">&#160;</span>(<a href="/wiki/Iobenguane" title="Iobenguane">Iobenguane (131I)</a>)</li> <li><a href="/wiki/Fluorine-18" title="Fluorine-18"><sup>18</sup>F</a> <ul><li><a href="/wiki/Fluciclovine_(18F)" title="Fluciclovine (18F)">Fluciclovine</a></li> <li><a href="/wiki/Fluorodeoxyglucose_(18F)" title="Fluorodeoxyglucose (18F)">Fluorodeoxyglucose</a></li> <li><a href="/wiki/Fluoroethyl-L-tyrosine_(18F)" title="Fluoroethyl-L-tyrosine (18F)">Fluoroethyltyrosine</a></li> <li><a href="/wiki/Sodium_fluoride" title="Sodium fluoride">Sodium fluoride</a></li></ul></li> <li><a href="/wiki/Copper-64" title="Copper-64"><sup>64</sup>Cu</a> <ul><li><a href="/wiki/Copper_(64Cu)_oxodotreotide" title="Copper (64Cu) oxodotreotide">Dotatate</a></li></ul></li> <li><a href="/wiki/Piflufolastat_F-18" title="Piflufolastat F-18">Piflufolastat F-18</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Adrenal_cortex" title="Adrenal cortex">Adrenal cortex</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Iodine-123" title="Iodine-123"><sup>123</sup>I</a></li> <li><a href="/wiki/Iodine-125" title="Iodine-125"><sup>125</sup>I</a> / <a href="/wiki/Iodine-131" title="Iodine-131"><sup>131</sup>I</a> (<a href="/wiki/19-Iodocholesterol" class="mw-redirect" title="19-Iodocholesterol">Iodocholesterol</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Radionuclide" title="Radionuclide">Radionuclides</a><br />(including <a href="/wiki/Radioactive_tracer" title="Radioactive tracer">tracers</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Positron" title="Positron">positron</a> (<a href="/wiki/PET_radiotracer" title="PET radiotracer">PET</a> <a href="/wiki/List_of_PET_radiotracers" title="List of PET radiotracers">list</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carbon-11" class="mw-redirect" title="Carbon-11"><sup>11</sup>C</a> (<a href="/wiki/11C_ME@HAPTHI" title="11C ME@HAPTHI">[<sup>11</sup>C]ME@HAPTHI</a>)</li> <li><a href="/wiki/25B-NBOMe" title="25B-NBOMe">25B-NBOMe</a> (Cimbi-36)</li> <li><a href="/wiki/Acetate" title="Acetate">Acetate</a></li> <li><a href="/wiki/Carbon-11-choline" title="Carbon-11-choline">Choline</a></li> <li><a href="/wiki/Carfentanil" title="Carfentanil">Carfentanil</a></li> <li><a href="/wiki/DASB" title="DASB">DASB</a></li> <li><a href="/wiki/DTBZ" class="mw-redirect" title="DTBZ">DTBZ</a></li> <li><a href="/wiki/Flumazenil" title="Flumazenil">Flumazenil</a></li> <li><a href="/wiki/Methionine" title="Methionine">Methionine</a></li> <li><a href="/wiki/N-Methylspiperone" title="N-Methylspiperone">N-Methylspiperone</a></li> <li><a href="/wiki/Pittsburgh_compound_B" title="Pittsburgh compound B">Pittsburgh compound B</a></li> <li><a href="/wiki/Raclopride" title="Raclopride">Raclopride</a></li> <li><a href="/wiki/Verapamil" title="Verapamil">Verapamil</a>)</li> <li><a href="/wiki/Nitrogen-13" title="Nitrogen-13"><sup>13</sup>N</a> <ul><li><a href="/wiki/Ammonia_(13N)" title="Ammonia (13N)">Ammonia</a></li></ul></li> <li><a href="/wiki/Copper-64" title="Copper-64"><sup>64</sup>Cu</a></li> <li><a href="/wiki/Desmethoxyfallypride" title="Desmethoxyfallypride">Desmethoxyfallypride</a></li> <li><a href="/wiki/Fallypride" title="Fallypride">Fallypride</a></li> <li><a href="/wiki/Florbetaben_(18F)" title="Florbetaben (18F)">Florbetaben (18F)</a></li> <li><a href="/wiki/Florbetapir_(18F)" title="Florbetapir (18F)">Florbetapir (18F)</a></li> <li><a href="/wiki/Flortaucipir_(18F)" title="Flortaucipir (18F)">Flortaucipir (18F)</a></li> <li><a href="/wiki/Flotufolastat_F-18" title="Flotufolastat F-18">Flotufolastat F-18</a></li> <li><a href="/w/index.php?title=Flubatine&amp;action=edit&amp;redlink=1" class="new" title="Flubatine (page does not exist)">Flubatine</a></li> <li><a href="/wiki/Fluciclovine" class="mw-redirect" title="Fluciclovine">Fluciclovine</a></li> <li><a href="/wiki/Fludeoxyglucose_(18F)" class="mw-redirect" title="Fludeoxyglucose (18F)">Fludeoxyglucose (18F)</a> (FDG)-<a href="/wiki/Glucose" title="Glucose">glucose</a> analogue</li> <li><a href="/wiki/Flumazenil" title="Flumazenil">Flumazenil</a></li> <li><a href="/wiki/Fluorine-18" title="Fluorine-18"><sup>18</sup>F</a> (<a href="/wiki/Altanserin" title="Altanserin">Altanserin</a>)</li> <li><a href="/wiki/Fluorocholine" title="Fluorocholine">Fluorocholine</a></li> <li><a href="/w/index.php?title=Fluorodeoxysorbitol&amp;action=edit&amp;redlink=1" class="new" title="Fluorodeoxysorbitol (page does not exist)">Fluorodeoxysorbitol</a> (FDS)</li> <li><a href="/wiki/Fluorodopa" title="Fluorodopa">Fluorodopa</a></li> <li><a href="/wiki/Fluoroestradiol_F-18" title="Fluoroestradiol F-18">Fluoroestradiol F-18</a></li> <li><a href="/wiki/Fluorothymidine_F-18" title="Fluorothymidine F-18">Fluorothymidine F-18</a></li> <li><a href="/wiki/Flurpiridaz_(18F)" title="Flurpiridaz (18F)">Flurpiridaz (18F)</a></li> <li><a href="/w/index.php?title=Fluspidine&amp;action=edit&amp;redlink=1" class="new" title="Fluspidine (page does not exist)">Fluspidine</a></li> <li><a href="/wiki/Flutemetamol" class="mw-redirect" title="Flutemetamol">Flutemetamol</a></li> <li><a href="/wiki/FMISO" title="FMISO">FMISO</a></li> <li><a href="/wiki/Gallium_(68Ga)_gozetotide" title="Gallium (68Ga) gozetotide">Gallium (<sup>68</sup>Ga) gozetotide</a></li> <li><a href="/wiki/Gallium-68" class="mw-redirect" title="Gallium-68"><sup>68</sup>Ga</a></li> <li><a href="/wiki/Mefway" class="mw-redirect" title="Mefway">Mefway</a></li> <li><a href="/wiki/MPPF" title="MPPF">MPPF</a></li> <li><a href="/wiki/N-Methylspiperone" title="N-Methylspiperone">N-Methylspiperone</a></li> <li><a href="/wiki/Nifene" title="Nifene">Nifene</a></li> <li><a href="/wiki/O-(2-fluorethyl)-L-thyrosine" class="mw-redirect" title="O-(2-fluorethyl)-L-thyrosine">FET</a></li> <li><a href="/wiki/Oxygen-15" class="mw-redirect" title="Oxygen-15"><sup>15</sup>O</a> (<a href="/wiki/Water" title="Water">Water</a>)</li> <li><a href="/wiki/Piflufolastat_F-18" title="Piflufolastat F-18">Piflufolastat F-18</a></li> <li><a href="/wiki/Rubidium-82" title="Rubidium-82"><sup>82</sup>Rb</a> (<a href="/wiki/Rubidium-82_chloride" title="Rubidium-82 chloride">Rubidium chloride</a>)</li> <li><a href="/wiki/Setoperone" title="Setoperone">Setoperone</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Gamma_ray" title="Gamma ray">gamma ray</a>/<a href="/wiki/Photon" title="Photon">photon</a> (<a href="/wiki/Single-photon_emission_computed_tomography" title="Single-photon emission computed tomography">SPECT</a>/<a href="/wiki/Scintigraphy" title="Scintigraphy">scintigraphy</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chromium-51" class="mw-redirect" title="Chromium-51"><sup>51</sup>Cr</a></li> <li><a href="/wiki/Cobalt-57" class="mw-redirect" title="Cobalt-57"><sup>57</sup>Co</a></li> <li><a href="/wiki/Gallium-67" class="mw-redirect" title="Gallium-67"><sup>67</sup>Ga</a></li> <li><a href="/wiki/Indium-111" title="Indium-111"><sup>111</sup>In</a></li> <li><a href="/wiki/Iodine-123" title="Iodine-123"><sup>123</sup>I</a></li> <li><a href="/wiki/Iodine-125" title="Iodine-125"><sup>125</sup>I</a></li> <li><a href="/wiki/Iodine-131" title="Iodine-131"><sup>131</sup>I</a></li> <li><a href="/wiki/Krypton-81m" class="mw-redirect" title="Krypton-81m"><sup>81m</sup>Kr</a></li> <li><a href="/wiki/Samarium-153" class="mw-redirect" title="Samarium-153"><sup>153</sup>Sm</a></li> <li><a href="/wiki/Selenium-75" class="mw-redirect" title="Selenium-75"><sup>75</sup>Se</a></li> <li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a></li> <li><a href="/wiki/Thallium-201" class="mw-redirect" title="Thallium-201"><sup>201</sup>Tl</a></li> <li><a href="/wiki/Xenon-133" class="mw-redirect" title="Xenon-133"><sup>133</sup>Xe</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>Isotopes used: <div class="hlist"> <ul><li><a href="/wiki/Carbon-11" class="mw-redirect" title="Carbon-11">carbon-11</a></li> <li><a href="/wiki/Chromium-51" class="mw-redirect" title="Chromium-51">chromium-51</a></li> <li><a href="/wiki/Cobalt-57" class="mw-redirect" title="Cobalt-57">cobalt-57</a></li> <li><a href="/wiki/Copper-64" title="Copper-64">copper-64</a></li> <li><a href="/wiki/Fluorine-18" title="Fluorine-18">fluorine-18</a></li> <li><a href="/wiki/Gallium-67" class="mw-redirect" title="Gallium-67">gallium-67</a></li> <li><a href="/wiki/Gallium-68" class="mw-redirect" title="Gallium-68">gallium-68</a></li> <li><a href="/wiki/Indium-111" title="Indium-111">indium-111</a></li> <li><a href="/wiki/Iodine-123" title="Iodine-123">iodine-123</a></li> <li><a href="/wiki/Iodine-125" title="Iodine-125">iodine-125</a></li> <li><a href="/wiki/Iodine-131" title="Iodine-131">iodine-131</a></li> <li><a href="/wiki/Krypton-81m" class="mw-redirect" title="Krypton-81m">krypton-81m</a></li> <li><a href="/wiki/Nitrogen-13" title="Nitrogen-13">nitrogen-13</a></li> <li><a href="/wiki/Oxygen-15" class="mw-redirect" title="Oxygen-15">oxygen-15</a></li> <li><a href="/wiki/Rubidium-82" title="Rubidium-82">rubidium-82</a></li> <li><a href="/wiki/Samarium-153" class="mw-redirect" title="Samarium-153">samarium-153</a></li> <li><a href="/wiki/Selenium-75" class="mw-redirect" title="Selenium-75">selenium-75</a></li> <li><a href="/wiki/Technetium-99m" title="Technetium-99m">technetium-99m</a></li> <li><a href="/wiki/Thallium-201" class="mw-redirect" title="Thallium-201">thallium-201</a></li> <li><a href="/wiki/Xenon-133" class="mw-redirect" title="Xenon-133">xenon-133</a></li></ul> </div><div class="hlist">See also: <a href="/wiki/ATC_code_V10" title="ATC code V10">Therapeutic radiopharmaceuticals (V10)</a> </div></div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output .portal-bar-header{margin:0 1em 0 0.5em;flex:0 0 auto;min-height:24px}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;flex:0 1 auto;padding:0.15em 0;column-gap:1em;align-items:baseline;margin:0;list-style:none}.mw-parser-output .portal-bar-content-related{margin:0;list-style:none}.mw-parser-output .portal-bar-item{display:inline-block;margin:0.15em 0.2em;min-height:24px;line-height:24px}@media screen and (max-width:768px){.mw-parser-output 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