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heart</title> <meta name="description" content="Search results for: aging heart"> <meta name="keywords" content="aging heart"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="aging heart"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1824</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: aging heart</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1824</span> Innovations in Healthy and Active Aging: A Case Study of "Aging in Place" in Northern California</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lisa%20Handwerker">Lisa Handwerker</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Using a Medical Anthropological lens, the paper will explore ideas elated to "aging in place" among Northern Californian older adults. Older adults seek independence, autonomy, flexibility, engagement, fulfillment and community in their pursuit of the highest quality of life. These values are at the heart of healthy and active "aging in place'. Drawing on a case study, the paper will examine one membership based non-profit organization for older adults united by the members' desire to be healthy and active while remaining in their homes for as long as possible. Relying on both volunteer and paid work, the paper explores the use of volunteer peer-to peer support, community building and advanced technologies toward this goal. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aging%20in%20place" title="aging in place">aging in place</a>, <a href="https://publications.waset.org/abstracts/search?q=healthy%20and%20active%20aging" title=" healthy and active aging"> healthy and active aging</a>, <a href="https://publications.waset.org/abstracts/search?q=northern%20california" title=" northern california"> northern california</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20anthropologist" title=" medical anthropologist"> medical anthropologist</a>, <a href="https://publications.waset.org/abstracts/search?q=engagement" title=" engagement"> engagement</a>, <a href="https://publications.waset.org/abstracts/search?q=autonomy" title=" autonomy"> autonomy</a>, <a href="https://publications.waset.org/abstracts/search?q=flexibility" title=" flexibility"> flexibility</a>, <a href="https://publications.waset.org/abstracts/search?q=community" title=" community"> community</a>, <a href="https://publications.waset.org/abstracts/search?q=volunteers" title=" volunteers"> volunteers</a>, <a href="https://publications.waset.org/abstracts/search?q=quality%20of%20life" title=" quality of life"> quality of life</a> </p> <a href="https://publications.waset.org/abstracts/157134/innovations-in-healthy-and-active-aging-a-case-study-of-aging-in-place-in-northern-california" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/157134.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">100</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1823</span> On-Chip Aging Sensor Circuit Based on Phase Locked Loop Circuit </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ararat%20Khachatryan">Ararat Khachatryan</a>, <a href="https://publications.waset.org/abstracts/search?q=Davit%20Mirzoyan"> Davit Mirzoyan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In sub micrometer technology, the aging phenomenon starts to have a significant impact on the reliability of integrated circuits by bringing performance degradation. For that reason, it is important to have a capability to evaluate the aging effects accurately. This paper presents an accurate aging measurement approach based on phase-locked loop (PLL) and voltage-controlled oscillator (VCO) circuit. The architecture is rejecting the circuit self-aging effect from the characteristics of PLL, which is generating the frequency without any aging phenomena affects. The aging monitor is implemented in low power 32 nm CMOS technology, and occupies a pretty small area. Aging simulation results show that the proposed aging measurement circuit improves accuracy by about 2.8% at high temperature and 19.6% at high voltage. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aging%20effect" title="aging effect">aging effect</a>, <a href="https://publications.waset.org/abstracts/search?q=HCI" title=" HCI"> HCI</a>, <a href="https://publications.waset.org/abstracts/search?q=NBTI" title=" NBTI"> NBTI</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoscale" title=" nanoscale"> nanoscale</a> </p> <a href="https://publications.waset.org/abstracts/65068/on-chip-aging-sensor-circuit-based-on-phase-locked-loop-circuit" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/65068.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">359</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1822</span> Aging Behaviour of 6061 Al-15 vol% SiC Composite in T4 and T6 Treatments</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Melby%20Chacko">Melby Chacko</a>, <a href="https://publications.waset.org/abstracts/search?q=Jagannath%20Nayak"> Jagannath Nayak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aging behaviour of 6061 Al-15 vol% SiC composite was investigated using Rockwell B hardness measurement. The composite was solutionized at 350°C and quenched in water. The composite was aged at room temperature (T4 treatment) and also at 140°C, 160°C, 180°C and 200°C (T6 treatment). The natural and artificial aging behaviour of composite was studied using aging curves determined at different temperatures. The aging period for peak aging for different temperatures was identified. The time required for attaining peak aging decreased with increase in the aging temperature. The peak hardness was found to increase with increase with aging temperature and the highest peak hardness was observed at 180ºC. Beyond 180ºC the peak hardness was found to be decreasing. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=6061%20Al-SiC%20composite" title="6061 Al-SiC composite">6061 Al-SiC composite</a>, <a href="https://publications.waset.org/abstracts/search?q=aging%20curve" title=" aging curve"> aging curve</a>, <a href="https://publications.waset.org/abstracts/search?q=Rockwell%20B%20hardness" title=" Rockwell B hardness"> Rockwell B hardness</a>, <a href="https://publications.waset.org/abstracts/search?q=T4" title=" T4"> T4</a>, <a href="https://publications.waset.org/abstracts/search?q=T6%20treatments" title=" T6 treatments"> T6 treatments</a> </p> <a href="https://publications.waset.org/abstracts/7313/aging-behaviour-of-6061-al-15-vol-sic-composite-in-t4-and-t6-treatments" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7313.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">267</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1821</span> Effect of Pre-Aging and Aging Parameters on Mechanical Behavior of Be-Treated 7075 Aluminum Alloys: Experimental Correlation using Minitab Software</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Tash">M. Tash</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Alkahtani"> S. Alkahtani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study was undertaken to investigate the effect of pre-aging and aging parameters (time and temperature) on the mechanical properties of Al-Mg-Zn (7075) alloys. Ultimate tensile strength, 0.5% offset yield strength and % elongation measurements were carried out on specimens prepared from cast and heat treated 7075 alloys. Duplex aging treatments were carried out for the as solution treated (SHT) specimens (pre-aged at different time and temperature followed by high temperature aging). A statistical design of experiments (DOE) approach using fractional factorial design was applied to determine the influence of controlling variables of pre-aging and aging treatment parameters and any interactions between them on the mechanical properties of 7075 alloys. A mathematical models are developed to relate the alloy ultimate tensile strength, yield strength and % elongation with the different pre-aging and aging parameters i.e. Pre-aging Temperature (PA T0C), Pre-aging time (PA t h), Aging temperature (AT0C), Aging time (At h), to acquire an understanding of the effects of these variables and their interactions on the mechanical properties of be-treated 7075 alloys. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aging%20heat%20Treatment" title="aging heat Treatment">aging heat Treatment</a>, <a href="https://publications.waset.org/abstracts/search?q=tensile%20properties" title=" tensile properties"> tensile properties</a>, <a href="https://publications.waset.org/abstracts/search?q=be-treated%20cast%20Al-Mg-Zn%20%287075%29%20alloys" title=" be-treated cast Al-Mg-Zn (7075) alloys"> be-treated cast Al-Mg-Zn (7075) alloys</a>, <a href="https://publications.waset.org/abstracts/search?q=experimental%20correlation" title=" experimental correlation"> experimental correlation</a> </p> <a href="https://publications.waset.org/abstracts/7396/effect-of-pre-aging-and-aging-parameters-on-mechanical-behavior-of-be-treated-7075-aluminum-alloys-experimental-correlation-using-minitab-software" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7396.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">275</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1820</span> Aging and Mechanical Behavior of Be-treated 7075 Aluminum Alloys</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahmoud%20M.%20Tash">Mahmoud M. Tash</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Alkahtani"> S. Alkahtani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study was undertaken to investigate the effect of pre-aging and aging parameters (time and temperature) on the mechanical properties of Al-Mg-Zn (7075) alloys. Ultimate tensile strength, 0.5% offset yield strength and % elongation measurements were carried out on specimens prepared from cast and heat treated 7075 alloys. Aging treatments were carried out for the as solution treated (SHT) specimens (after quenching in warm water). The specimens were aged at different conditions; Natural aging was carried out at room temperature for different periods of time. Double aging was performed for SHT conditions (pre-aged at different time and temperature followed by high temperature aging). Ultimate tensile strength, yield strength and % elongation as a function of different pre-aging and aging parameters are analysed to acquire an understanding of the effects of these variables and their interactions on the mechanical properties of Be-treated 7075 alloys. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=duplex%20aging%20treatment" title="duplex aging treatment">duplex aging treatment</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanical%20properties" title=" mechanical properties"> mechanical properties</a>, <a href="https://publications.waset.org/abstracts/search?q=Al-Mg-Zn%20%287075%29%20alloys" title=" Al-Mg-Zn (7075) alloys"> Al-Mg-Zn (7075) alloys</a>, <a href="https://publications.waset.org/abstracts/search?q=manufacturing" title=" manufacturing"> manufacturing</a> </p> <a href="https://publications.waset.org/abstracts/7395/aging-and-mechanical-behavior-of-be-treated-7075-aluminum-alloys" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7395.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">240</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1819</span> Mathematical Based Forecasting of Heart Attack</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Razieh%20Khalafi">Razieh Khalafi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to part of the heart causing damage to the heart muscle. An ECG can often show evidence of a previous heart attack or one that's in progress. The patterns on the ECG may indicate which part of your heart has been damaged, as well as the extent of the damage. In chaos theory, the correlation dimension is a measure of the dimensionality of the space occupied by a set of random points, often referred to as a type of fractal dimension. In this research by considering ECG signal as a random walk we work on forecasting the oncoming heart attack by analyzing the ECG signals using the correlation dimension. In order to test the model a set of ECG signals for patients before and after heart attack was used and the strength of model for forecasting the behavior of these signals were checked. Results shows this methodology can forecast the ECG and accordingly heart attack with high accuracy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heart%20attack" title="heart attack">heart attack</a>, <a href="https://publications.waset.org/abstracts/search?q=ECG" title=" ECG"> ECG</a>, <a href="https://publications.waset.org/abstracts/search?q=random%20walk" title=" random walk"> random walk</a>, <a href="https://publications.waset.org/abstracts/search?q=correlation%20dimension" title=" correlation dimension"> correlation dimension</a>, <a href="https://publications.waset.org/abstracts/search?q=forecasting" title=" forecasting"> forecasting</a> </p> <a href="https://publications.waset.org/abstracts/29782/mathematical-based-forecasting-of-heart-attack" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29782.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">541</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1818</span> A New Mathematical Method for Heart Attack Forecasting</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Razi%20Khalafi">Razi Khalafi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Myocardial Infarction (MI) or acute Myocardial Infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to part of the heart causing damage to the heart muscle. An ECG can often show evidence of a previous heart attack or one that's in progress. The patterns on the ECG may indicate which part of your heart has been damaged, as well as the extent of the damage. In chaos theory, the correlation dimension is a measure of the dimensionality of the space occupied by a set of random points, often referred to as a type of fractal dimension. In this research by considering ECG signal as a random walk we work on forecasting the oncoming heart attack by analysing the ECG signals using the correlation dimension. In order to test the model a set of ECG signals for patients before and after heart attack was used and the strength of model for forecasting the behaviour of these signals were checked. Results show this methodology can forecast the ECG and accordingly heart attack with high accuracy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heart%20attack" title="heart attack">heart attack</a>, <a href="https://publications.waset.org/abstracts/search?q=ECG" title=" ECG"> ECG</a>, <a href="https://publications.waset.org/abstracts/search?q=random%20walk" title=" random walk"> random walk</a>, <a href="https://publications.waset.org/abstracts/search?q=correlation%20dimension" title=" correlation dimension"> correlation dimension</a>, <a href="https://publications.waset.org/abstracts/search?q=forecasting" title=" forecasting"> forecasting</a> </p> <a href="https://publications.waset.org/abstracts/30802/a-new-mathematical-method-for-heart-attack-forecasting" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30802.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">506</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1817</span> Improvement of Mechanical Properties and Corrosion Resistance of AA7056 Aluminum Alloys by the Non-isothermal Aging Process</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tse-An%20Pan">Tse-An Pan</a>, <a href="https://publications.waset.org/abstracts/search?q=Sheng-Long%20Lee"> Sheng-Long Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The effect of non-isothermal aging on the mechanical properties and corrosion resistance of Al-9Zn-2.3Mg-1.9Cu (AA7056) alloys was investigated. The results revealed that thick materials were limited to retrogression and re-aging treatment (RRA). It could not reach the retrogression temperature in the RRA treatment. Compared with the RRA treatment, the non-isothermal aging (NIA) treatment produced discontinuous precipitates at grain boundaries, while the intragranular precipitates were fine and dense. The strength was similar to that of the RRA treatment; the corrosion resistance of the alloy was significantly improved by NIA aging. NIA treatment was less affected by the thickness of the alloy. The difference between the actual temperature and the setting temperature of the alloy is minimal during the aging process. The combination of properties could overcome the fact that RRA treatment cannot handle thick materials. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Al-Zn-Mg-Cu%20alloy" title="Al-Zn-Mg-Cu alloy">Al-Zn-Mg-Cu alloy</a>, <a href="https://publications.waset.org/abstracts/search?q=corrosion" title=" corrosion"> corrosion</a>, <a href="https://publications.waset.org/abstracts/search?q=retrogression" title=" retrogression"> retrogression</a>, <a href="https://publications.waset.org/abstracts/search?q=re-aging" title=" re-aging"> re-aging</a>, <a href="https://publications.waset.org/abstracts/search?q=non-isothermal%20aging" title=" non-isothermal aging"> non-isothermal aging</a> </p> <a href="https://publications.waset.org/abstracts/162230/improvement-of-mechanical-properties-and-corrosion-resistance-of-aa7056-aluminum-alloys-by-the-non-isothermal-aging-process" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/162230.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">181</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1816</span> Heart Murmurs and Heart Sounds Extraction Using an Algorithm Process Separation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fatima%20Mokeddem">Fatima Mokeddem</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The phonocardiogram signal (PCG) is a physiological signal that reflects heart mechanical activity, is a promising tool for curious researchers in this field because it is full of indications and useful information for medical diagnosis. PCG segmentation is a basic step to benefit from this signal. Therefore, this paper presents an algorithm that serves the separation of heart sounds and heart murmurs in case they exist in order to use them in several applications and heart sounds analysis. The separation process presents here is founded on three essential steps filtering, envelope detection, and heart sounds segmentation. The algorithm separates the PCG signal into S1 and S2 and extract cardiac murmurs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=phonocardiogram%20signal" title="phonocardiogram signal">phonocardiogram signal</a>, <a href="https://publications.waset.org/abstracts/search?q=filtering" title=" filtering"> filtering</a>, <a href="https://publications.waset.org/abstracts/search?q=Envelope" title=" Envelope"> Envelope</a>, <a href="https://publications.waset.org/abstracts/search?q=Detection" title=" Detection"> Detection</a>, <a href="https://publications.waset.org/abstracts/search?q=murmurs" title=" murmurs"> murmurs</a>, <a href="https://publications.waset.org/abstracts/search?q=heart%20sounds" title=" heart sounds"> heart sounds</a> </p> <a href="https://publications.waset.org/abstracts/114970/heart-murmurs-and-heart-sounds-extraction-using-an-algorithm-process-separation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/114970.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">140</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1815</span> Target and Biomarker Identification Platform to Design New Drugs against Aging and Age-Related Diseases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Peter%20Fedichev">Peter Fedichev</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We studied fundamental aspects of aging to develop a mathematical model of gene regulatory network. We show that aging manifests itself as an inherent instability of gene network leading to exponential accumulation of regulatory errors with age. To validate our approach we studied age-dependent omic data such as transcriptomes, metabolomes etc. of different model organisms and humans. We build a computational platform based on our model to identify the targets and biomarkers of aging to design new drugs against aging and age-related diseases. As biomarkers of aging, we choose the rate of aging and the biological age since they completely determine the state of the organism. Since rate of aging rapidly changes in response to an external stress, this kind of biomarker can be useful as a tool for quantitative efficacy assessment of drugs, their combinations, dose optimization, chronic toxicity estimate, personalized therapies selection, clinical endpoints achievement (within clinical research), and death risk assessments. According to our model, we propose a method for targets identification for further interventions against aging and age-related diseases. Being a biotech company, we offer a complete pipeline to develop an anti-aging drug-candidate. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aging" title="aging">aging</a>, <a href="https://publications.waset.org/abstracts/search?q=longevity" title=" longevity"> longevity</a>, <a href="https://publications.waset.org/abstracts/search?q=biomarkers" title=" biomarkers"> biomarkers</a>, <a href="https://publications.waset.org/abstracts/search?q=senescence" title=" senescence"> senescence</a> </p> <a href="https://publications.waset.org/abstracts/41675/target-and-biomarker-identification-platform-to-design-new-drugs-against-aging-and-age-related-diseases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41675.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">274</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1814</span> Evaluating the Durability and Safety of Lithium-Ion Batterie in High-Temperature Desert Climates</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kenza%20Maher">Kenza Maher</a>, <a href="https://publications.waset.org/abstracts/search?q=Yahya%20Zakaria"> Yahya Zakaria</a>, <a href="https://publications.waset.org/abstracts/search?q=Noora%20S.%20Al-Jaidah"> Noora S. Al-Jaidah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Temperature is a critical parameter for lithium-ion battery performance, life, and safety. In this study, four commercially available 18650 lithium-ion cells from four different manufacturers are subjected to accelerated cycle aging for up to 500 cycles at two different temperatures (25°C and 45°C). The cells are also calendar-aged at the same temperatures in both charged and discharged states for 6 months to investigate the effect of aging and temperature on capacity fade and state of health. The results showed that all battery cells demonstrated good cyclability and had a good state of health at both temperatures. However, the capacity loss and state of health of these cells are found to be dependent on the cell chemistry and aging conditions, including temperature. Specifically, the capacity loss is found to be higher at the higher aging temperature, indicating the significant impact of temperature on the aging of lithium-ion batteries. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lithium-ion%20battery" title="lithium-ion battery">lithium-ion battery</a>, <a href="https://publications.waset.org/abstracts/search?q=aging%20mechanisms" title=" aging mechanisms"> aging mechanisms</a>, <a href="https://publications.waset.org/abstracts/search?q=cycle%20aging" title=" cycle aging"> cycle aging</a>, <a href="https://publications.waset.org/abstracts/search?q=calendar%20aging." title=" calendar aging."> calendar aging.</a> </p> <a href="https://publications.waset.org/abstracts/165119/evaluating-the-durability-and-safety-of-lithium-ion-batterie-in-high-temperature-desert-climates" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165119.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">99</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1813</span> Case Study of the Exercise Habits and Aging Anxiety of Taiwanese Insurance Agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=W.%20T.%20Hsu">W. T. Hsu</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20L.%20Tsai"> H. L. Tsai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The rapid aging of the population is a common trend in the world. However, the progress of modern medical technology has increased the average life expectancy. The global population structure has changed dramatically, and the elderly population has risen rapidly. In the face of rapid population growth, it must be noted issues of the aging population must face up to, which are the physiological, psychological, and social problems associated with aging. This study aims to investigate how insurance agents are actively dealing with an aging society, their own aging anxiety, and their exercise habits. Purposive sampling was the sampling method of this study, a total of 204 respondents were surveyed and 204 valid surveys were returned. The returned valid ratio was 100%. Statistical method included descriptive statistics, <em>t</em>-test, and one-way ANOVA. The results of the study found that the insurance agent’s age, seniority, exercise habits to aging anxiety are significantly different. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=insurance%20practitioners" title="insurance practitioners">insurance practitioners</a>, <a href="https://publications.waset.org/abstracts/search?q=aging%20anxiety" title=" aging anxiety"> aging anxiety</a>, <a href="https://publications.waset.org/abstracts/search?q=exercise%20habits" title=" exercise habits"> exercise habits</a>, <a href="https://publications.waset.org/abstracts/search?q=elderly" title=" elderly"> elderly</a> </p> <a href="https://publications.waset.org/abstracts/72820/case-study-of-the-exercise-habits-and-aging-anxiety-of-taiwanese-insurance-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/72820.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">309</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1812</span> Intelligent System for Diagnosis Heart Attack Using Neural Network</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Oluwaponmile%20David%20Alao">Oluwaponmile David Alao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Misdiagnosis has been the major problem in health sector. Heart attack has been one of diseases that have high level of misdiagnosis recorded on the part of physicians. In this paper, an intelligent system has been developed for diagnosis of heart attack in the health sector. Dataset of heart attack obtained from UCI repository has been used. This dataset is made up of thirteen attributes which are very vital in diagnosis of heart disease. The system is developed on the multilayer perceptron trained with back propagation neural network then simulated with feed forward neural network and a recognition rate of 87% was obtained which is a good result for diagnosis of heart attack in medical field. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heart%20attack" title="heart attack">heart attack</a>, <a href="https://publications.waset.org/abstracts/search?q=artificial%20neural%20network" title=" artificial neural network"> artificial neural network</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnosis" title=" diagnosis"> diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=intelligent%20system" title=" intelligent system"> intelligent system</a> </p> <a href="https://publications.waset.org/abstracts/33844/intelligent-system-for-diagnosis-heart-attack-using-neural-network" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33844.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">655</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1811</span> The Effects of Aging on the Cost of Operating and Support: An Empirical Study Applied to Weapon Systems</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Byungchae%20Kim">Byungchae Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Jiwoo%20Nam"> Jiwoo Nam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aging of weapon systems can cause the failure and degeneration of components which results in increase of operating and support costs. However, whether this aging effect is significantly strong and it influences a lot on national defense spending due to the rapid increase in operating and support (O&S) costs is questionable. To figure out this, we conduct a literature review analyzing the aging effect of US weapon systems. We also conduct an empirical research using a maintenance database of Korean weapon systems, Defense Logistics Integrated Information System (DAIIS). We run regression of various types of O&S cost on weapon system age to investigate the statistical significance of aging effect and use generalized linear model to find relations between the failure of different priced components and the age. Our major finding is although aging effect exists, its impacts on weapon system cost seem to be not too large considering several characteristics of O&S cost elements not relying on the age. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=O%26S%20cost" title="O&S cost">O&S cost</a>, <a href="https://publications.waset.org/abstracts/search?q=aging%20effect" title=" aging effect"> aging effect</a>, <a href="https://publications.waset.org/abstracts/search?q=weapon%20system" title=" weapon system"> weapon system</a>, <a href="https://publications.waset.org/abstracts/search?q=GLM" title=" GLM"> GLM</a> </p> <a href="https://publications.waset.org/abstracts/121195/the-effects-of-aging-on-the-cost-of-operating-and-support-an-empirical-study-applied-to-weapon-systems" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/121195.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1810</span> Development of Sleep Quality Index Using Heart Rate</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dongjoo%20Kim">Dongjoo Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Chang-Sik%20Son"> Chang-Sik Son</a>, <a href="https://publications.waset.org/abstracts/search?q=Won-Seok%20Kang"> Won-Seok Kang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Adequate sleep affects various parts of one’s overall physical and mental life. As one of the methods in determining the appropriate amount of sleep, this research presents a heart rate based sleep quality index. In order to evaluate sleep quality using the heart rate, sleep data from 280 subjects taken over one month are used. Their sleep data are categorized by a three-part heart rate range. After categorizing, some features are extracted, and the statistical significances are verified for these features. The results show that some features of this sleep quality index model have statistical significance. Thus, this heart rate based sleep quality index may be a useful discriminator of sleep. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sleep" title="sleep">sleep</a>, <a href="https://publications.waset.org/abstracts/search?q=sleep%20quality" title=" sleep quality"> sleep quality</a>, <a href="https://publications.waset.org/abstracts/search?q=heart%20rate" title=" heart rate"> heart rate</a>, <a href="https://publications.waset.org/abstracts/search?q=statistical%20analysis" title=" statistical analysis"> statistical analysis</a> </p> <a href="https://publications.waset.org/abstracts/52817/development-of-sleep-quality-index-using-heart-rate" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52817.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">340</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1809</span> The Role of Spiritual Experience, Gerotranscendence and Social Engagement on Successful Aging among Incarcerated Filipino Elderly: A Structural Equation Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Les%20Paul%20Valdez">Les Paul Valdez</a>, <a href="https://publications.waset.org/abstracts/search?q=Rowena%20Manzarate"> Rowena Manzarate</a>, <a href="https://publications.waset.org/abstracts/search?q=Joseph%20Carl%20Lunizo"> Joseph Carl Lunizo</a>, <a href="https://publications.waset.org/abstracts/search?q=Mary%20Thereze%20Mabaquiao"> Mary Thereze Mabaquiao</a>, <a href="https://publications.waset.org/abstracts/search?q=Mary%20Deo%20Luigi%20Mabunay"> Mary Deo Luigi Mabunay</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Across the literature, varying definitions of successful aging can be found. As a result, several determinants have been associated with successful aging. However, there is a paucity of literature exploring the relationship between successful aging and factors such as spiritual experience, gerotranscendence, and social engagement. Objective: Thus, this study purports to ascertain the relationship between and among spiritual experience, gerotranscendence, social engagement and successful aging. Methods: The Daily Spiritual Experience Scale (DSES), Social Engagement Scale (SES), Gerotranscendence Scale Revised (GS-R) and Expectations Regarding Aging (ERA) were fielded to 349 incarcerated elderly to measure spiritual experience, social engagement, gerotranscendence and successful aging respectively. Data was analyzed using Structural Equation Modelling through AMOS 21. The hypothesized model was evaluated using the goodness of fit and parsimony indices. Results: Social engagement (β= .179, p=.128) and spiritual experience (β= .375, p=.262) contribute to successful aging through the mediating effect of gerotranscendence (β= .973, p=.718). Conclusion: Today more than ever, healthcare providers in penal institutions are challenged to ensure that incarcerated elderly are socially and spiritually engaged; and have high levels of gerotranscendence. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=elderly" title="elderly">elderly</a>, <a href="https://publications.waset.org/abstracts/search?q=Filipino" title=" Filipino"> Filipino</a>, <a href="https://publications.waset.org/abstracts/search?q=gerotranscendence" title=" gerotranscendence"> gerotranscendence</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20engagement" title=" social engagement"> social engagement</a>, <a href="https://publications.waset.org/abstracts/search?q=spiritual%20experience" title=" spiritual experience"> spiritual experience</a>, <a href="https://publications.waset.org/abstracts/search?q=successful%20aging" title=" successful aging "> successful aging </a> </p> <a href="https://publications.waset.org/abstracts/46006/the-role-of-spiritual-experience-gerotranscendence-and-social-engagement-on-successful-aging-among-incarcerated-filipino-elderly-a-structural-equation-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46006.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">522</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1808</span> Aging Among Older Immigrant Women</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Michele%20Charpentier">Michele Charpentier</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This article examines the experiences of aging of older immigrant women. The data are based on qualitative research that was conducted in Quebec/Canada with 83 elderly women from different ethno-cultural backgrounds (Arab, African, Haitian, Japanese, Chinese, Portuguese, Romanian, etc.). The results on how such immigrant women deal with material conditions of existence such as deskilling, aging alone, being more economically independent and the combined effects of liberation from social and family norms associated with age and gender in the light of the migration route, will be presented. For the majority, migration opened up possibilities for personal development and self-affirmation. The findings demonstrated the relevance of the intersectional approach in understanding the complexity and social conditionings of women’s experiences of aging. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=older%20immigrant%20women" title="older immigrant women">older immigrant women</a>, <a href="https://publications.waset.org/abstracts/search?q=qualitative%20research" title=" qualitative research"> qualitative research</a>, <a href="https://publications.waset.org/abstracts/search?q=experiences%20of%20aging" title=" experiences of aging"> experiences of aging</a>, <a href="https://publications.waset.org/abstracts/search?q=intersectional%20approach" title=" intersectional approach"> intersectional approach</a> </p> <a href="https://publications.waset.org/abstracts/178996/aging-among-older-immigrant-women" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/178996.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">52</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1807</span> Precipitation and Age Hardening in Al-Mg-Si-(Cu) Alloys for Automotive Body Sheet</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tahar%20Abid">Tahar Abid</a>, <a href="https://publications.waset.org/abstracts/search?q=Haoues%20Ghouss"> Haoues Ghouss</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdelhamid%20Boubertakh"> Abdelhamid Boubertakh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This present work is focused on the hardening precipitation in two AlMgSi(Cu) automotive body sheets. The effect of pre-aging, aging treatment and 0.10 wt % copper addition on the hardening response was investigated using scanning calorimetry (DSC), transmission electron microscopy (TEM), and Vickers microhardness measurements (Hv). The results reveal the apparition of α-AlFeSi, α-AlFe(Mn)Si type precipitates frequently present and witch remain stable at high temperature in Al-Mg-Si alloys. Indeed, the hardening response in both sheets is certainly due to the predominance of very fine typical phases β' and β'' as rods and needles developed during aging with and without pre-aging. The effect of pre ageing just after homogenization and quenching is to correct the undesirable effect of aging at ambient temperature by making faster alloy hardening during artificial aging.The addition of 0.10 wt % copper has allowed to refine and to enhance the precipitation hardening after quenching. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=AlMgSi%20alloys" title="AlMgSi alloys">AlMgSi alloys</a>, <a href="https://publications.waset.org/abstracts/search?q=precipitation" title=" precipitation"> precipitation</a>, <a href="https://publications.waset.org/abstracts/search?q=hardening" title=" hardening"> hardening</a>, <a href="https://publications.waset.org/abstracts/search?q=activation%20energy" title=" activation energy"> activation energy</a> </p> <a href="https://publications.waset.org/abstracts/166964/precipitation-and-age-hardening-in-al-mg-si-cu-alloys-for-automotive-body-sheet" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/166964.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">89</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1806</span> Spectral Response Measurements and Materials Analysis of Ageing Solar Photovoltaic Modules</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=T.%20H.%20Huang">T. H. Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Y.%20Gao"> C. Y. Gao</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20H.%20Lin"> C. H. Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20L.%20Kwo"> J. L. Kwo</a>, <a href="https://publications.waset.org/abstracts/search?q=Y.%20K.%20Tseng"> Y. K. Tseng</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The design and reliability of solar photovoltaic modules are crucial to the development of solar energy, and efforts are still being made to extend the life of photovoltaic modules to improve their efficiency because natural aging is time-consuming and does not provide manufacturers and investors with timely information, accelerated aging is currently the best way to estimate the life of photovoltaic modules. In this study, the accelerated aging of different light sources was combined with spectral response measurements to understand the effect of light sources on aging tests. In this study, there are two types of experimental samples: packaged and unpackaged and then irradiated with full-spectrum and UVC light sources for accelerated aging, as well as a control group without aging. The full-spectrum aging was performed by irradiating the solar cell with a xenon lamp like the solar spectrum for two weeks, while the accelerated aging was performed by irradiating the solar cell with a UVC lamp for two weeks. The samples were first visually observed, and infrared thermal images were taken, and then the electrical (IV) and Spectral Responsivity (SR) data were obtained by measuring the spectral response of the samples, followed by Scanning Electron Microscopy (SEM), Raman spectroscopy (Raman), and X-ray Diffraction (XRD) analysis. The results of electrical (IV) and Spectral Responsivity (SR) and material analyses were used to compare the differences between packaged and unpackaged solar cells with full spectral aging, accelerated UVC aging, and unaged solar cells. The main objective of this study is to compare the difference in the aging of packaged and unpackaged solar cells by irradiating different light sources. We determined by infrared thermal imaging that both full-spectrum aging and UVC accelerated aging increase the defects of solar cells, and IV measurements demonstrated that the conversion efficiency of solar cells decreases after full-spectrum aging and UVC accelerated aging. SEM observed some scorch marks on both unpackaged UVC accelerated aging solar cells and unpackaged full-spectrum aging solar cells. Raman spectroscopy examines the Si intensity of solar cells, and XRD confirms the crystallinity of solar cells by the intensity of Si and Ag winding peaks. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=solar%20cell" title="solar cell">solar cell</a>, <a href="https://publications.waset.org/abstracts/search?q=aging" title=" aging"> aging</a>, <a href="https://publications.waset.org/abstracts/search?q=spectral%20response%20measurement" title=" spectral response measurement"> spectral response measurement</a> </p> <a href="https://publications.waset.org/abstracts/150077/spectral-response-measurements-and-materials-analysis-of-ageing-solar-photovoltaic-modules" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/150077.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">102</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1805</span> Simulation of Human Heart Activation Based on Diffusion Tensor Imaging</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ihab%20Elaff">Ihab Elaff</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Simulating the heart’s electrical stimulation is essential in modeling and evaluating the electrophysiology behavior of the heart. For achieving that, there are two structures in concern: the ventricles’ Myocardium, and the ventricles’ Conduction Network. Ventricles’ Myocardium has been modeled as anisotropic material from Diffusion Tensor Imaging (DTI) scan, and the Conduction Network has been extracted from DTI as a case-based structure based on the biological properties of the heart tissues and the working methodology of the Magnetic Resonance Imaging (MRI) scanner. Results of the produced activation were much similar to real measurements of the reference model that was presented in the literature. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diffusion%20tensor" title="diffusion tensor">diffusion tensor</a>, <a href="https://publications.waset.org/abstracts/search?q=DTI" title=" DTI"> DTI</a>, <a href="https://publications.waset.org/abstracts/search?q=heart" title=" heart"> heart</a>, <a href="https://publications.waset.org/abstracts/search?q=conduction%20network" title=" conduction network"> conduction network</a>, <a href="https://publications.waset.org/abstracts/search?q=excitation%20propagation" title=" excitation propagation"> excitation propagation</a> </p> <a href="https://publications.waset.org/abstracts/75607/simulation-of-human-heart-activation-based-on-diffusion-tensor-imaging" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75607.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">265</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1804</span> Does Exercise Training Moderate the Effects of Ageing on Health</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Elizabeth%20A.%20Haruna">Elizabeth A. Haruna</a>, <a href="https://publications.waset.org/abstracts/search?q=Bulus%20Kpame"> Bulus Kpame</a>, <a href="https://publications.waset.org/abstracts/search?q=Kankanala%20Venkateswarlu"> Kankanala Venkateswarlu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The interaction of health and athletic performance with biologic aging has been an interesting and intriguing area for research. There has been a general acknowledgement of its importance to major public health and elite performance outcomes. There are many questions unanswered about the mechanisms of effects and dose-response changes. An attempt has been made in this paper to highlight potentially positive effects of regular training on the aging process and its effects on health. Age associated decline in health and performance results from the combination of the aging process itself, inactive lifestyle and primary diseases. An attempt is made in this paper to critically review what is known and what is unknown about evidence based changes, common to disuse and aging. Mechanisms responsible for the slowing decline in muscle mass and muscle force (sarcopenia) down of age – associated, weakness and fatigability due to year round athletic training have been discussed. It is in this regard we have attempted to share our views on advances made so far in understanding the impact of aging on health. We also attempted to explain how the biological effects of aging are minimized during appropriate year round athletic training. On the basis of available research evidence it was concluded that exercise training significantly slow down the deleterious effects of aging on health. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aging" title="aging">aging</a>, <a href="https://publications.waset.org/abstracts/search?q=atrophy" title=" atrophy"> atrophy</a>, <a href="https://publications.waset.org/abstracts/search?q=sarcopenia" title=" sarcopenia"> sarcopenia</a>, <a href="https://publications.waset.org/abstracts/search?q=plyometric%20training" title=" plyometric training"> plyometric training</a> </p> <a href="https://publications.waset.org/abstracts/31160/does-exercise-training-moderate-the-effects-of-ageing-on-health" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31160.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">415</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1803</span> Chest Pain as a Predictor for Heart Issues in Geriatrics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Leila%20Kargar">Leila Kargar</a>, <a href="https://publications.waset.org/abstracts/search?q=Homa%20Abri"> Homa Abri</a>, <a href="https://publications.waset.org/abstracts/search?q=Golsa%20Safai"> Golsa Safai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The occurrence of chest pain among geriatrics could be considered as a predictor of heart issues. There is a need for attention to this pain among this population. This review paper has tried to collect the recent data with attention to the chest pain among geriatrics. This review paper has focused on specific keywords, including chest pain, heart issues, and geriatrics, among published papers from 2015 till 2020. To collect data for this purpose, Scopus, Web of Sciences, and PubMed were used. After inserting related papers to the Endnote, an independent researcher checked the abstract, and papers with unclear methods or non-English language were excluded. Finally, 7-papers were included in this review paper. The findings of those papers showed that chest pain could be a predictor for heart issues, and also, there is a direct relationship between chest pain and heart issues among geriatrics. So, early detection and an accurate decision could be helpful to prevent heart issues in this population. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pain" title="pain">pain</a>, <a href="https://publications.waset.org/abstracts/search?q=heart%20issue" title=" heart issue"> heart issue</a>, <a href="https://publications.waset.org/abstracts/search?q=geriatrics" title=" geriatrics"> geriatrics</a>, <a href="https://publications.waset.org/abstracts/search?q=health" title=" health"> health</a> </p> <a href="https://publications.waset.org/abstracts/140884/chest-pain-as-a-predictor-for-heart-issues-in-geriatrics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140884.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">218</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1802</span> Wearable Heart Rate Sensor Based on Wireless System for Heart Health Monitoring</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Murtadha%20Kareem">Murtadha Kareem</a>, <a href="https://publications.waset.org/abstracts/search?q=Oliver%20Faust"> Oliver Faust</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Wearable biosensor systems can be designed and developed for health monitoring. There is much interest in both scientific and industrial communities established since 2007. Fundamentally, the cost of healthcare has increased dramatically and the world population is aging. That creates the need to harvest technological improvements with small bio-sensing devices, wireless-communication, microelectronics and smart textiles, that leads to non-stop developments of wearable sensor based systems. There has been a significant demand to monitor patient's health status while the patient leaves the hospital in his/her personal environment. To address this need, there are numerous system prototypes which has been launched in the medical market recently, the aim of that is to provide real time information feedback about patient's health status, either to the patient himself/herself or direct to the supervising medical centre station, while being capable to give a notification for the patient in case of possible imminent health threatening conditions. Furthermore, wearable health monitoring systems comprise new techniques to address the problem of managing and monitoring chronic heart diseases for elderly people. Wearable sensor systems for health monitoring include various types of miniature sensors, either wearable or implantable. To be specific, our proposed system able to measure essential physiological parameter, such as heart rate signal which could be transmitted through Bluetooth to the cloud server in order to store, process, analysis and visualise the data acquisition. The acquired measurements are connected through internet of things to a central node, for instance an android smart phone or tablet used for visualising the collected information on application or transmit it to a medical centre. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wearable%20sensor" title="Wearable sensor">Wearable sensor</a>, <a href="https://publications.waset.org/abstracts/search?q=Heart%20rate" title=" Heart rate"> Heart rate</a>, <a href="https://publications.waset.org/abstracts/search?q=Internet%20of%20things" title=" Internet of things"> Internet of things</a>, <a href="https://publications.waset.org/abstracts/search?q=Chronic%20heart%20disease" title=" Chronic heart disease"> Chronic heart disease</a> </p> <a href="https://publications.waset.org/abstracts/100678/wearable-heart-rate-sensor-based-on-wireless-system-for-heart-health-monitoring" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/100678.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">161</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1801</span> Effect of Be, Zr, and Heat Treatment on Mechanical Behavior of Cast Al-Mg-Zn-Cu Alloys (7075)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahmoud%20M.%20Tash">Mahmoud M. Tash</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study was undertaken to investigate the effect of aging parameters (time and temperature) on the mechanical properties of Be-and/or Zr- treated Al-Mg-Zn (7075) alloys. Ultimate tensile strength, 0.5% offset yield strength and % elongation measurements were carried out on specimens prepared from cast and heat treated 7075 alloys containing Be and/or Zr. Different aging treatment were carried out for the as solution treated (SHT) specimens. The specimens were aged at different conditions; Natural and artificial aging was carried out at room temperature, 120C, 150C, 180C and 220C for different periods of time. Duplex aging was performed for SHT conditions (pre-aged at different time and temperature followed by high temperature aging). Ultimate tensile strength, yield strength and % elongation data results as a function of different aging parameters are analysed. A statistical design of experiments (DOE) approach using fractional factorial design is applied to acquire an understanding of the effects of these variables and their interactions on the mechanical properties of Be- and/or Zr- treated 7075 alloys. Mathematical models are developed to relate the alloy mechanical properties with the different aging parameters. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=casting%20aging%20treatment" title="casting aging treatment">casting aging treatment</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanical%20properties" title=" mechanical properties"> mechanical properties</a>, <a href="https://publications.waset.org/abstracts/search?q=Al-Mg-Zn%20alloys" title=" Al-Mg-Zn alloys"> Al-Mg-Zn alloys</a>, <a href="https://publications.waset.org/abstracts/search?q=Be-%20and%2For%20Zr-treatment" title=" Be- and/or Zr-treatment"> Be- and/or Zr-treatment</a>, <a href="https://publications.waset.org/abstracts/search?q=experimental%20correlation" title=" experimental correlation"> experimental correlation</a> </p> <a href="https://publications.waset.org/abstracts/21737/effect-of-be-zr-and-heat-treatment-on-mechanical-behavior-of-cast-al-mg-zn-cu-alloys-7075" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21737.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">364</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1800</span> Product Design and Development of Wearable Assistant Device</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hao-Jun%20Hong">Hao-Jun Hong</a>, <a href="https://publications.waset.org/abstracts/search?q=Jung-Tang%20Huang"> Jung-Tang Huang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The world is gradually becoming an aging society, and with the lack of laboring forces, this phenomenon is affecting the nation’s economy growth. Although nursing centers are booming in recent years, the lack of medical resources are yet to be resolved, thus creating an innovative wearable medical device could be a vital solution. This research is focused on the design and development of a wearable device which obtains a more precise heart failure measurement than products on the market. The method used by the device is based on the sensor fusion and big data algorithm. From the test result, the modified structure of wearable device can significantly decrease the MA (Motion Artifact) and provide users a more cozy and accurate physical monitor experience. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=big%20data" title="big data">big data</a>, <a href="https://publications.waset.org/abstracts/search?q=heart%20failure" title=" heart failure"> heart failure</a>, <a href="https://publications.waset.org/abstracts/search?q=motion%20artifact" title=" motion artifact"> motion artifact</a>, <a href="https://publications.waset.org/abstracts/search?q=sensor%20fusion" title=" sensor fusion"> sensor fusion</a>, <a href="https://publications.waset.org/abstracts/search?q=wearable%20medical%20device" title=" wearable medical device"> wearable medical device</a> </p> <a href="https://publications.waset.org/abstracts/59226/product-design-and-development-of-wearable-assistant-device" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59226.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">350</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1799</span> Slovenia in the Heart of Europe</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20%C5%BDibert">M. Žibert</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20%C5%A0pindler"> T. Špindler</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Uhan"> S. Uhan</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Lisec"> A. Lisec</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We can find Slovenia in the heart of Europe and has really good geographical location. With same slogan are promoted Switzerland, Montenegro, Greece and probably many others. However, from anatomic point of view, injustice is being made to someone because the heart is placed only in left part of chest cavity and there we can`t find place for the entire territory from Switzerland to the south of Balkan. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ljubljana" title="Ljubljana">Ljubljana</a>, <a href="https://publications.waset.org/abstracts/search?q=logistics" title=" logistics"> logistics</a>, <a href="https://publications.waset.org/abstracts/search?q=Slovenia" title=" Slovenia"> Slovenia</a>, <a href="https://publications.waset.org/abstracts/search?q=tourism" title=" tourism"> tourism</a> </p> <a href="https://publications.waset.org/abstracts/13625/slovenia-in-the-heart-of-europe" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13625.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">374</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1798</span> Determination of Myocardial Function Using Heart Accumulated Radiopharmaceuticals</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=C.%20C%20.D.%20Kulathilake">C. C .D. Kulathilake</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Jayatilake"> M. Jayatilake</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Takahashi"> T. Takahashi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The myocardium is composed of specialized muscle which relies mainly on fatty acid and sugar metabolism and it is widely contribute to the heart functioning. The changes of the cardiac energy-producing system during heart failure have been proved using autoradiography techniques. This study focused on evaluating sugar and fatty acid metabolism in myocardium as cardiac energy getting system using heart-accumulated radiopharmaceuticals. Two sets of autoradiographs of heart cross sections of Lewis male rats were analyzed and the time- accumulation curve obtained with use of the MATLAB image processing software to evaluate fatty acid and sugar metabolic functions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=autoradiographs" title="autoradiographs">autoradiographs</a>, <a href="https://publications.waset.org/abstracts/search?q=fatty%20acid" title=" fatty acid"> fatty acid</a>, <a href="https://publications.waset.org/abstracts/search?q=radiopharmaceuticals" title=" radiopharmaceuticals"> radiopharmaceuticals</a>, <a href="https://publications.waset.org/abstracts/search?q=sugar" title=" sugar"> sugar</a> </p> <a href="https://publications.waset.org/abstracts/33660/determination-of-myocardial-function-using-heart-accumulated-radiopharmaceuticals" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33660.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">450</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1797</span> Design of Demand Pacemaker Using an Embedded Controller</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=C.%20Bala%20Prashanth%20Reddy">C. Bala Prashanth Reddy</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Abhinay"> B. Abhinay</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Sreekar"> C. Sreekar</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20V.%20Shobhana%20Priscilla"> D. V. Shobhana Priscilla</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The project aims in designing an emergency pacemaker which is capable of giving shocks to a human heart which has stopped working suddenly. A pacemaker is a machine commonly used by cardiologists. This machine is used in order to shock a human’s heart back into usage. The way the heart works is that there are small cells called pacemakers sending electrical pulses to cardiac muscles that tell the heart when to pump blood. When these electrical pulses stop, the heart stops beating. When this happens, a pacemaker is used to shock the heart muscles and the pacemakers back into action. The way this is achieved is by rubbing the two panels of the pacemaker together to create an adequate electrical current, and then the heart gets back to the normal state. The project aims in designing a system which is capable of continuously displaying the heart beat and blood pressure of a person on LCD. The concerned doctor gets the heart beat and also the blood pressure details continuously through the GSM Modem in the form of SMS alerts. In case of abnormal condition, the doctor sends message format regarding the amount of electric shock needed. Automatically the microcontroller gives the input to the pacemaker which in turn gives the shock to the patient. Heart beat monitor and display system is a portable and a best replacement for the old model stethoscope which is less efficient. The heart beat rate is calculated manually using stethoscope where the probability of error is high because the heart beat rate lies in the range of 70 to 90 per minute whose occurrence is less than 1 sec, so this device can be considered as a very good alternative instead of a stethoscope. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=missing%20R%20wave" title="missing R wave">missing R wave</a>, <a href="https://publications.waset.org/abstracts/search?q=PWM" title=" PWM"> PWM</a>, <a href="https://publications.waset.org/abstracts/search?q=demand%20pacemaker" title=" demand pacemaker"> demand pacemaker</a>, <a href="https://publications.waset.org/abstracts/search?q=heart" title=" heart"> heart</a> </p> <a href="https://publications.waset.org/abstracts/11057/design-of-demand-pacemaker-using-an-embedded-controller" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/11057.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">482</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1796</span> Poincare Plot for Heart Rate Variability </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mazhar%20B.%20Tayel">Mazhar B. Tayel</a>, <a href="https://publications.waset.org/abstracts/search?q=Eslam%20I.%20AlSaba"> Eslam I. AlSaba</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The heart is the most important part in any body organisms. It effects and affected by any factor in the body. Therefore, it is a good detector of any matter in the body. When the heart signal is non-stationary signal, therefore, it should be study its variability. So, the Heart Rate Variability (HRV) has attracted considerable attention in psychology, medicine and have become important dependent measure in psychophysiology and behavioral medicine. Quantification and interpretation of heart rate variability. However, remain complex issues are fraught with pitfalls. This paper presents one of the non-linear techniques to analyze HRV. It discusses 'What Poincare plot is?', 'How it is work?', 'its usage benefits especially in HRV', 'the limitation of Poincare cause of standard deviation SD1, SD2', and 'How overcome this limitation by using complex correlation measure (CCM)'. The CCM is most sensitive to changes in temporal structure of the Poincaré plot as compared to SD1 and SD2. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heart%20rate%20variability" title="heart rate variability">heart rate variability</a>, <a href="https://publications.waset.org/abstracts/search?q=chaotic%20system" title=" chaotic system"> chaotic system</a>, <a href="https://publications.waset.org/abstracts/search?q=poincare" title=" poincare"> poincare</a>, <a href="https://publications.waset.org/abstracts/search?q=variance" title=" variance"> variance</a>, <a href="https://publications.waset.org/abstracts/search?q=standard%20deviation" title=" standard deviation"> standard deviation</a>, <a href="https://publications.waset.org/abstracts/search?q=complex%20correlation%20measure" title=" complex correlation measure"> complex correlation measure</a> </p> <a href="https://publications.waset.org/abstracts/35154/poincare-plot-for-heart-rate-variability" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/35154.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">399</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1795</span> Sex Differences in Age-Related AMPK-Sirt1 Axis Alteration in Human Heart</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Maria%20Luisa%20Barcena%20De%20Arellano">Maria Luisa Barcena De Arellano</a>, <a href="https://publications.waset.org/abstracts/search?q=Sofya%20Pozdniakova"> Sofya Pozdniakova</a>, <a href="https://publications.waset.org/abstracts/search?q=Pavelas%20Karkacas"> Pavelas Karkacas</a>, <a href="https://publications.waset.org/abstracts/search?q=Anja%20Kuhl"> Anja Kuhl</a>, <a href="https://publications.waset.org/abstracts/search?q=Istvan%20Baczko"> Istvan Baczko</a>, <a href="https://publications.waset.org/abstracts/search?q=Yury%20Ladilov"> Yury Ladilov</a>, <a href="https://publications.waset.org/abstracts/search?q=Vera%20Regitz-Zagrosek"> Vera Regitz-Zagrosek</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Aging is associated with deterioration of the physiological function, leading to systemic inflammation and mitochondrial dysfunction that promote the development of cardiovascular diseases. Sex differences in aging-related cardiovascular diseases have been postulated. However, their precise mechanisms remain unclear. In the current study, we aimed to investigate the sex difference in the age-related alteration in Sirt1-AMPK signaling and its relation to the mitochondrial biogenesis and inflammation. Methods: Male and female human non-disease lateral left ventricular wall tissue (young (17–40 years; n= 7 male and 7 female) and old (50–68 years; n= 9 male and 8 female)) were used. qRT-PCR, western blot and immunohistochemistry assays were performed for expression analyses of Sirt1, AMPK, pAMPK, ac-Ku70, TFAM, PGC-1α, Sirt3, SOD2 and catalase. CD68 was used as a marker for macrophages and the ratio of IL-12:IL10 (pro-inflammatory phenotype (high IL-12/low IL-10) and anti-inflammatory phenotype (low IL-12/high IL-10) was used to examine the inflammatory stage in the heart. Results: Sirt1 expression was significantly higher in young females compared to young males, whereas in aged hearts Sirt1 expression was significantly downregulated in females, but not in males. In line with the Sirt1 downregulation in aged females, acetylation of nuclear Ku70, a direct target of Sirt1, in aged female hearts was significantly elevated. The activity of AMPK was significantly decreased in aged individuals, however no sex differences in the AMPK expression or activity were found in young or old individuals. The expression of mitochondrial proteins TOM40, SOD2 and Sirt3 was significantly higher in young females compared to young males, while in aged female hearts SOD2 and TOM40 were downregulated. In addition, the expression of catalase, a key cytosolic and mitochondrial anti-oxidative enzyme was significantly higher in young females and this female sex benefit was lost in aged hearts. In addition, the number of cardiac macrophages was significantly increased in old female, but not in male hearts. Consistently, the pro-inflammatory shift in old females was further confirmed by differences in the IL12/IL10 ratio in young female cardiac tissue in a favour of the anti-inflammatory mediator IL-10 (ratio 1:4) compared to young males (ratio 1:1). The anti-inflammatory environment in the heart was lost in aged females (ratio 1:1). Conclusion: Aging leads to the significant downregulation of Sirt1 expression and elevated acetylation of Ku70 in female, but not in male hearts. Furthermore, a beneficial upregulation of mitochondrial and anti-oxidative proteins in young females is lost with aging. Moreover, the malfunctions in the expression of Sirt1 and mitochondrial proteins in aged female hearts is accompanied by a significant pro-inflammatory shift. The study provides a molecular basis for the increased incidence of cardiovascular diseases in old women. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=inflammation" title="inflammation">inflammation</a>, <a href="https://publications.waset.org/abstracts/search?q=mitochondrial%20dysfunction" title=" mitochondrial dysfunction"> mitochondrial dysfunction</a>, <a href="https://publications.waset.org/abstracts/search?q=aging" title=" aging"> aging</a>, <a href="https://publications.waset.org/abstracts/search?q=Sirt1-AMPK%20axis" title=" Sirt1-AMPK axis"> Sirt1-AMPK axis</a> </p> <a href="https://publications.waset.org/abstracts/84168/sex-differences-in-age-related-ampk-sirt1-axis-alteration-in-human-heart" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/84168.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">262</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=5">5</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=6">6</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=7">7</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=8">8</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=9">9</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=10">10</a></li> <li class="page-item disabled"><span class="page-link">...</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=60">60</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=61">61</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=aging%20heart&page=2" rel="next">&rsaquo;</a></li> </ul> </div> </main> 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