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margin-bottom: 20px !important; margin-top: 20px;} .box-shadws ul li{font-size: 14px;} </style>  <section id="about-section" class="about-section sec-ptb-50 clearfix" style="padding-bottom: 60px;"> <div class="container"> <div class="row">  <div class="col-lg-3"> <aside> <div class="widget innergrouplinks"> <div class="widget__tag"> <ul> <li><a href="scientific-program.php">Tentative Program <i class="fas fa-arrow-circle-right" aria-hidden="true"></i></a></li> <li><a href="abstract-submission.php">Abstract Submission <i class="fas fa-arrow-circle-right" aria-hidden="true"></i></a></li> <li><a href="registrations.php">Registration <i class="fas fa-arrow-circle-right" aria-hidden="true"></i></a></li> <li><a href="sponsorship-exhibitor.php">Sponsorship / Exhibitor <i class="fas fa-arrow-circle-right" aria-hidden="true"></i></a></li> <li><a href="venue-and-hospitality.php">Venue and Hospitality <i class="fas fa-arrow-circle-right" aria-hidden="true"></i></a></li> <li><a href="contact.php">Contact Us <i class="fas fa-arrow-circle-right" aria-hidden="true"></i></a></li> </ul> </div> </div> <div class="widget innergrouplinks notes"> <h4>Note</h4> <div class="widget__tag"> <div class="col-md-12"> <ul> <li><a href="abstract-submission.php">Second Round Abstract Submission Ends: Dec 16th, 2024</a></li> <li><a href="registrations.php">Mid-Term Registration Ends: December 18th, 2024</a></li> </ul> </div> </div> </div> <div class="widget innergrouplinks notes"> <h4>GET IN TOUCH</h4> <div class="widget__tag"> <div class="col-md-12"> <p>Feel free to drop us a line; we will get back to you within 24 hours. For quick assistance, you can call or email us.</p> <div class="footer-widget"> <div class="content"> <p><i class="far fa-envelope"></i> longevityfederation@sciinovhealth.com</p> </div> <div class="content"> <p><i class="fa fa-phone"></i> +1 732 526 1166 </p> </div> </div> </div> </div> </div> </aside> </div> <div class="col-lg-9 baclpadtop"> <div class="row"> <div class="box-shadws clearfix"> <div class="col-md-12 col-sm-12"> <p>There are many theories of the biological causes of aging, which suggests that many different mechanisms contribute to the aging process. </p> <p>Kirkwood proposed that the underlying cause is mainly due to the accumulation of random unrepaired molecular damage over time. This eventually leads to cellular defects and tissue dysfunction resulting in increased frailty and age-related diseases. </p> <p>Our cells possess quality control systems so that molecular damage can be recognized, repaired or removed. However, due to the energy requirements of these systems, somatic maintenance is not 100% efficient. All molecular components are susceptible to damage including DNA, proteins, lipids and organelles. Sources of damage may be intrinsic, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) or extrinsic such as UV light, irradiation and exposure to toxins. </p> <p>In terms of aging, exposure to sources of damage over the human lifespan will vary among individuals and may in part explain the heterogeneity in how individuals age.</p> <p>The rate of accumulation of stress-induced random molecular damage is dependent on the capacity of the antioxidant system and efficiency of repair systems. As these systems are not 100% efficient, cells always contain some unrepaired damage that leads to activation of a stress response and up-regulation of mechanisms to remove the damage or to prevent the cell division. However, these responses also become less efficient with age so that damaged components accumulate leading to cellular defects, which gives rise to tissue dysfunction and aging.</p> <p>Many studies into the molecular mechanisms of aging have focused on a particular theory such as the accumulation of somatic mutations, DNA damage and repair, telomere shortening, Loss of protein homoeostasis, Molecular chaperones, protein degradation pathways, protein aggregation, mitochondrial damage and dysfunction, Dysregulation of cellular signalling, DNA methylation dynamics and computational modelling.</p> </div> </div> </div> <div class="section-title text-justify mb-30"> <div class="scientific-sessions"> <ul class="scientific"> <li class="equal details-btn" ><a href="scientific-sessions-details/Healthy-Aging-and-Longevity">Healthy Aging and Longevity</a></li> <li class="equal details-btn" ><a href="scientific-sessions-details/Science-and-Mechanisms-of-Aging-">Science and Mechanisms of Aging 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Scientists say mifepristone, used in cancer and reproductive care, could pave the way for anti-aging treatments.</a></p> </div> </div> </div> </div> </div>  <div class="col-lg-3 col-md-6 col-sm-12"> <div class="usefullinks-wrapper ul-li-block"> <h3 class="footer-item-title"> useful <strong>links</strong> </h3> <ul> <li><a href="about.php">About Us</a></li> <li><a href="brochure-download.php">Brochure Download</a></li> <li><a href="https://wongjowo.id/">Abstract Submission</a></li> <li><a href="accommodation.php">Accommodation</a></li> <li><a href="registrations.php">Registration</a></li> <li><a href="contact.php">Contact us</a></li> </ul> </div> </div>     <div class="col-lg-3 col-md-6 col-sm-12"> <div> <blockquote class="twitter-tweet"><p lang="en" dir="ltr">馃棧锔廜ur invited speaker for 3rd Edition Global Longevity Federation (HYBRID)-Rome, Italy on August 12-13, 2024 is David Barzilai, <a href="https://twitter.com/agingdoc1?ref_src=twsrc%5Etfw">@agingdoc1</a> <br><br>馃摐"Defining a Longevity Medicine for the Future: Perspectives from a Longevity Medicine Consultant"<br><br>Details: <a href="https://t.co/kTvmghnMgQ">https://t.co/kTvmghnMgQ</a> <a href="https://t.co/rjPCBxALdA">pic.twitter.com/rjPCBxALdA</a></p>— 3rd Edition Global Longevity Federation 2024 (@Longevity25252) <a href="https://twitter.com/Longevity25252/status/1774671800971981095?ref_src=twsrc%5Etfw">April 1, 2024</a></blockquote> <script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script> </div> </div>  </div> </div> </div>  <div class="footer-bottom"> <div class="container"> <div class="row">  <div class="col-lg-7 col-md-12 col-sm-12"> <div class="copyright-text"> <p class="m-0">Copyright 漏 2024-2025 <a href="#!" class="site-link">Sciinov Group.</a> All Rights Reserved.</p> </div> </div>   <div class="col-lg-5 col-md-12 col-sm-12"> <div class="footer-menu"> <ul> <li><a href="terms-conditions.php">Terms and Conditions </a></li> <li><a href="privacy-policy.php">Privacy policy</a></li> </ul> </div> </div>  </div> </div> </div> </footer>  <script src="assets/js/jquery-3.3.1.min.js"></script> <script src="assets/js/popper.min.js"></script> <script src="assets/js/bootstrap.min.js"></script>  <script src="assets/js/slick.min.js"></script> <script src="assets/js/owl.carousel.min.js"></script>  <script src="assets/js/atc.min.js"></script>  <script src="assets/js/jquery.magnific-popup.min.js"></script> <script src="assets/js/isotope.pkgd.min.js"></script> <script src="assets/js/jarallax.min.js"></script> <script src="assets/js/jquery.mCustomScrollbar.concat.min.js"></script>  <script src="assets/js/imagesloaded.pkgd.min.js"></script>  <script src="assets/js/jquery.countdown.js"></script>  <script src="assets/js/custom.js"></script> <script> $(document).ready(function() { $("#owl-demo").owlCarousel({ items : 5, lazyLoad : true, autoPlay:3000, navigationText: [ "<i class='icon-chevron-left icon-white'><</i>", "<i class='icon-chevron-right icon-white'>></i>"], navigation : true }); }); </script> <script> equalheight = function(container){ var currentTallest = 0, currentRowStart = 0, rowDivs = new Array(), $el, topPosition = 0; $(container).each(function() { $el = $(this); $($el).height('auto') topPostion = $el.position().top; if (currentRowStart != topPostion) { for (currentDiv = 0 ; currentDiv < rowDivs.length ; currentDiv++) { rowDivs[currentDiv].height(currentTallest); } rowDivs.length = 0; // empty the array currentRowStart = topPostion; currentTallest = $el.height(); rowDivs.push($el); } else { rowDivs.push($el); currentTallest = (currentTallest < $el.height()) ? 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