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class='st-default-search-input search-field' id="st-default-search-box" placeholder='Search...' disabled/><span class="input_icon-clear" style="display: none;"><i></i></span></div><div class="mt_search_input-suggestions"><h5 class="mt_search-suggestions-label">Search suggestions</h5><ul><li>ph meter</li><li>balance</li><li>conductivity</li><li>counting platform scale</li><li>ind570</li></ul></div></div></form><div class="kws_category_dropdown"><div class="kws_filter_desktop"><span id="kws-category-text"> All Categories </span><span class="kws_arrow_wrap"><i class="kws_arrow"></i></span></div><div class="kws_list_wrap"><ul class="kws_filter_list"><li data-search-category="ALL" data-triggers-search="true" data-retarget-ad-enabled="true">All Categories</li><li data-search-category="PRODUCTS" data-triggers-search="true" data-retarget-ad-enabled="true">Products</li><li data-search-category="BUY_ONLINE" data-triggers-search="false" data-retarget-ad-enabled="false">Buy Online</li><li data-search-category="SUPPORT" data-triggers-search="true" data-retarget-ad-enabled="false">Support</li><li data-search-category="EXPERTISE" data-triggers-search="true" data-retarget-ad-enabled="false">Expertise</li><li data-search-category="EVENTS_AND_WEBINARS" data-triggers-search="true" data-retarget-ad-enabled="false">Events & Webinars</li><li data-search-category="OTHER" data-triggers-search="true" data-retarget-ad-enabled="false">Other</li></ul></div></div><div class="kws_filter_mobile"><div class="kws_filter-toggle"><div class="filter-symbol"><div class="elipse-top-left"></div><div class="vector-top"></div><div class="elipse-bottom-right"></div><div class="vector-bottom"></div></div><div class="search-filter-label"> Filter <div class="kws-selected-filter-count hidden"></div></div></div></div></div></div><div class="header_icon-close"><i></i></div><script type="module"> var wrapId = "search-"; var searchInstance = new Search({"id": wrapId}); </script> </div></div><div class="MTMainNav__icons top_meta_layer"><div class="header_search-icon disabled"><svg width="18" height="18" viewBox="0 0 18 18" fill="none" xmlns="http://www.w3.org/2000/svg"><path class="svgIcon--primary-blue" d="M12.5 11H11.71L11.43 10.73C12.41 9.59 13 8.11 13 6.5C13 2.91 10.09 0 6.5 0C2.91 0 0 2.91 0 6.5C0 10.09 2.91 13 6.5 13C8.11 13 9.59 12.41 10.73 11.43L11 11.71V12.5L16 17.49L17.49 16L12.5 11ZM6.5 11C4.01 11 2 8.99 2 6.5C2 4.01 4.01 2 6.5 2C8.99 2 11 4.01 11 6.5C11 8.99 8.99 11 6.5 11Z" fill="#004494"/></svg></div><div class="cartIconWrapper carticon"><script src="/etc.clientlibs/mt/components/content/digitalselling/carticon/clientlib.min-v55.js"></script> <template id="mt-cart-icon-template"><style type="text/css">.cart-icon-container{display:flex;position:relative;flex-flow:row;float:right;height:56px;font-family:Arial;font-style:normal;font-weight:700;font-size:12px;line-height:12px;text-align:center;color:#fff;vertical-align:middle}.cart-icon-container .mt-carticon-btn{border:0;background-color:#fff;margin-top:4px;cursor:pointer;position:relative;padding:0}.cart-icon-container .mt-carticon-btn .mt-carticon-svg-container{display:inline-flex;justify-content:center;width:40px;height:40px;align-items:center}.cart-icon-container .mt-carticon-btn .mt-carticon-svg-container:hover{background-color:#0044941a;border-radius:50%}.cart-icon-container .mt-carticon-btn .count{display:none;flex-direction:column;justify-content:center;align-items:center;padding:2px 4px;min-width:16px;height:16px;max-height:16px;background:#6bb847;border-radius:16px;color:#fff;position:absolute;right:4px;top:10px;box-sizing:border-box;font-size:10px}.mt-carticon-menu{position:absolute;right:5px;top:42px;text-align:left;display:none}.mt-carticon-menu ul{box-sizing:border-box;display:flex;flex-direction:column;align-items:flex-start;padding:10px 10px 0 10px;width:188px;background:#fff;border:1px solid #ccc;box-shadow:0 4px 8px #0000001a;z-index:100;list-style:none}.mt-carticon-menu ul li:first-child{border-bottom:1px solid #ccc}.mt-carticon-menu ul li:last-child{padding-top:10px}.mt-carticon-menu ul li{width:100%;padding-bottom:10px;font-size:14px;line-height:21px}.mt-carticon-menu ul li a{height:20px;font-style:normal;font-weight:400;font-size:14px;line-height:20px;color:#666;width:100%;display:inline-block;text-decoration:none}.mt-carticon-menu ul li a:hover{color:#004494}@media(max-width:767px){.mt-carticon-menu{position:fixed;width:100%;right:0;top:44px}.mt-carticon-menu ul{width:auto;height:auto}.mt-carticon-menu ul li{line-height:28px}}</style><div class="cart-icon-container mt-minicart-container"><button class="mt-carticon-btn"><div class="mt-carticon-svg-container"><svg width="24" height="24" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg"><g clip-path="url(#clip0_23367_36463)"><path d="M7 18C5.9 18 5.01 18.9 5.01 20C5.01 21.1 5.9 22 7 22C8.1 22 9 21.1 9 20C9 18.9 8.1 18 7 18ZM1 2V4H3L6.6 11.59L5.25 14.04C5.09 14.32 5 14.65 5 15C5 16.1 5.9 17 7 17H19V15H7.42C7.28 15 7.17 14.89 7.17 14.75L7.2 14.63L8.1 13H15.55C16.3 13 16.96 12.59 17.3 11.97L20.88 5.48C20.96 5.34 21 5.17 21 5C21 4.45 20.55 4 20 4H5.21L4.27 2H1ZM17 18C15.9 18 15.01 18.9 15.01 20C15.01 21.1 15.9 22 17 22C18.1 22 19 21.1 19 20C19 18.9 18.1 18 17 18Z" fill="#004494"/></g><defs><clipPath id="clip0_23367_36463"><rect width="24" height="24" fill="white"/></clipPath></defs></svg></div><span class="count"></span></button><div class="mt-carticon-menu" style="display:none;"><ul><li><a data-href="/shop/MT_BROWSING_CNTY/MT_BROWSING_LANG/cart"> View Cart </a></li><li><a data-href="/shop/MT_BROWSING_CNTY/MT_BROWSING_LANG/home"> Visit Online Store </a></li></ul></div></div></template><mt-cart-icon style="outline:none !important;" langCode="en_GB" currencyCode="CHF" locale="en-CH" dsHost="https://www.mt.com"></mt-cart-icon></div><div id="cnty_lang_placeholder"><div class="countrydropdown"><div class="head_cntylang meta_selection country" data-selectedcountrytitle="Switzerland" data-contenthandlecountry="ch"><div class="meta_select select_country "><a href="javascript:void(0);"><span class="base_sprite countryFlag" style="background-position: -353px -28px;"></span></a></div></div></div></div><div class="loginIconWrapper loginicon"><script src="/etc.clientlibs/mt/components/content/digitalselling/loginicon/clientlib.min-v55.js"></script> <template id="mt-login-icon-template"><style type="text/css">.login-icon-container{display:flex;position:relative;flex-flow:row;float:right;height:56px;font-family:Arial;font-style:normal;font-weight:700;font-size:12px;line-height:12px;text-align:center;color:#666;vertical-align:middle}.login-icon-container .mt-loginicon-btn{border:0;background-color:#fff;margin-top:4px;cursor:pointer;padding:0}.login-icon-container .mt-loginicon-btn .mt-loginicon-svg-container,.login-icon-container .mt-loginicon-btn .mt-loginicon-letter-container{display:inline-flex;justify-content:center;width:40px;height:40px;align-items:center}.login-icon-container .mt-loginicon-btn .mt-loginicon-letter-container{display:none}.login-icon-container .mt-loginicon-btn .mt-loginicon-svg-container:hover,.login-icon-container .mt-loginicon-btn .mt-loginicon-letter-container:hover{background-color:#0044941a;border-radius:50%}.mt-loginicon-menu{position:absolute;right:5px;top:42px;text-align:left;display:none;min-width:200px}.mt-loginicon-menu ul{box-sizing:border-box;display:none;flex-direction:column;align-items:flex-start;padding:10px 10px 0 10px;background:#fff;border:1px solid #ccc;box-shadow:0 4px 8px #0000001a;z-index:100;list-style:none}.login-icon-menu-active .mt-loginicon-menu{display:block}.mt-loginicon-menu.in ul.menu_in,.mt-loginicon-menu.out ul.menu_out{display:block}.mt-loginicon-menu ul li:first-child{padding-top:0}.mt-loginicon-menu ul li:last-child{border-bottom:0}.mt-loginicon-menu ul li{width:100%;padding-bottom:10px;font-size:14px;line-height:21px;padding-top:10px;border-bottom:1px solid #ccc}.mt-loginicon-menu ul li a{height:20px;font-style:normal;font-weight:400;font-size:14px;line-height:20px;color:#666;width:100%;display:inline-block;text-decoration:none}.mt-loginicon-menu ul li a:hover,.mt-loginicon-menu ul.menu_out li a{color:#004494}.mt-loginicon-menu ul li p{font-size:12px;font-weight:400;line-height:1.5rem;margin:4px 0 0 0}.mt-loginicon-letter-container .loggedInUserLetter{display:flex;background-color:#004494;width:20px;height:20px;margin:0 auto;border-radius:50%;color:white;align-items:center;justify-content:center}.mt-loginicon-letter-container .loggedInUserLetter span{display:block;font-size:12px;margin-left:1px}@media(max-width:767px){.mt-loginicon-menu{position:fixed;width:100%;right:0;top:44px}.mt-loginicon-menu ul{width:auto;height:auto}.mt-loginicon-menu ul li{line-height:28px}}</style><div class="login-icon-container mt-minicart-container"><button class="mt-loginicon-btn"><div class="mt-loginicon-letter-container"><div class="loggedInUserLetter"><span class="initial"></span></div></div><div class="mt-loginicon-svg-container"><svg width="20" height="20" viewBox="0 0 20 20" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M10 0C4.48 0 0 4.48 0 10C0 15.52 4.48 20 10 20C15.52 20 20 15.52 20 10C20 4.48 15.52 0 10 0ZM10 3C11.66 3 13 4.34 13 6C13 7.66 11.66 9 10 9C8.34 9 7 7.66 7 6C7 4.34 8.34 3 10 3ZM10 17.2C7.5 17.2 5.29 15.92 4 13.98C4.03 11.99 8 10.9 10 10.9C11.99 10.9 15.97 11.99 16 13.98C14.71 15.92 12.5 17.2 10 17.2Z" fill="#004494"/></svg></div><span class="count"></span></button><div class="mt-loginicon-menu" style="display:none;"><ul class="menu_out"><li><a data-href="/shop/MT_BROWSING_CNTY/MT_BROWSING_LANG/login"> myMT.com login </a><p> Manage your online profile and customize your mt.com experience </p></li><li><a data-href="/shop/MT_BROWSING_CNTY/MT_BROWSING_LANG/login/customerPortal"> Customer Portal Login </a><p> Browse a custom portfolio, access quotes, and manage your installed devices on our extended digital platform. </p></li></ul><ul class="menu_in"><li><a data-href="/shop/MT_BROWSING_CNTY/MT_BROWSING_LANG/account"> My Account </a></li><li><a data-href="/shop/MT_BROWSING_CNTY/MT_BROWSING_LANG/logout"> Logout </a></li><li><a data-href="/shop/MT_BROWSING_CNTY/MT_BROWSING_LANG/login/customerPortal"> Customer Portal </a></li></ul></div></div></template><mt-login-icon></mt-login-icon></div><div class="mt_mobile_header_nav"><button class="hamburger hamburger--collapse" type="button" aria-label="Toggle Navigation Menu"><span class="hamburger-box"><span class="hamburger-inner"></span></span></button></div></div></div><div class="mt_mobile_header_nav_dropdown"><div class="mainNav_mobileLoading_spinner-wrap" style="display:none;"><div class="mt-spinner-dark"></div></div><div class="mt_mobile_header_country_lang_wrap"><div class="mt_mobile_header_country"><div 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data-labelerrorloadingdata='There was a problem loading country data. Please refresh the page and try again.'><div class="mt-spinner-dark"></div></div><div class="cs_language"><div class="head_cntylang meta_selection lang"><div class="meta_select select_language"><div class="wrapper">English</div></div><div class="dropdown_container"><div class="meta_dropdown" id="dropdown_language"><div class="scroll_area"><ul><li><a href="/ch/de/home/products/L1_AutochemProducts/scale-up-systems.html" style="">Deutsch</a></li><li><a href="/ch/fr/home/products/L1_AutochemProducts/scale-up-systems.html" style="">Français</a></li><li><a href="/ch/it/home/products/L1_AutochemProducts/scale-up-systems.html" style="">Italiano</a></li><li><a href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems.html" style="">English</a></li></ul></div></div></div></div></div></div><link rel="stylesheet" href="/etc.clientlibs/mt/components/content/header/clientlib-bookings.min-v55.css" type="text/css"><div class="mt_engagement" style="display: none;"><div class="mt_engagement__info"><div class="mt_engagement__info__header"><span class="mt_engagement__info__header__text"> Need assistance? </span><svg class="mt_engagement__info__btn--collapse" width="20" height="20" viewBox="0 0 20 20" fill="none" xmlns="http://www.w3.org/2000/svg"><g clip-path="url(#clip0_9361_17182)"><path fill-rule="evenodd" clip-rule="evenodd" d="M11.4142 10L19.0405 2.37377L17.6263 0.959557L10 8.58578L2.37381 0.959557L0.959595 2.37377L8.58582 10L0.959595 17.6262L2.37381 19.0404L10 11.4142L17.6263 19.0404L19.0405 17.6262L11.4142 10Z" fill="#666666"/></g><defs><clipPath id="clip0_9361_17182"><rect width="20" height="20" fill="white"/></clipPath></defs></svg><svg class="mt_engagement__info__btn--expand" width="24" height="24" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M16.5 21L7.5 12L16.5 3" stroke="#666666" stroke-width="2"/></svg></div><span class="mt_engagement__info__body"> Our team is here to achieve your goals! 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srcset="/dam/direct-upload/image_asset_migration/products/L1_AutochemProducts/scale-up-systems/biologicsv4-icon-300x300-png/_jcr_content/renditions/original.webp" media="(min-width: 801px)" type="image/webp"><img loading="lazy" src="/dam/direct-upload/image_asset_migration/products/L1_AutochemProducts/scale-up-systems/biologicsv4-icon-300x300-png" alt="biologics scale up software" title="biologics scale up software"></picture></a></div></div><div class="card-body"><a href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems/dynochem-biologics.html" target="_self"><h3 class="card-title">Dynochem Biologics™</h3></a><h4 class="card-subtitle">Accelerate Bioprocess Development </h4><p> Process development and scale-up tools for upstream (USP), downstream (DSP), and fill/finish processes. Predict process behavior and design digital twins to improve bioprocess manufacturing. <span class="read-more"><a href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems/dynochem-biologics.html" target="_self"> Read more </a></span></p><div class="ppUX2020_design_readmore" style="display:none;"><i class="ppUX2020_arrow"></i></div></div></div></div><div class="extra-content"><div class="advantagesCarouselSlidePar3 parsys"></div></div></div></div></div></div></div></div></div><div class="featuredtextandimage section"><link rel="stylesheet" href="/etc.clientlibs/mt/components/content/featuredtextandimage/clientlib.min-v55.css" type="text/css"><div class="cross-template-component "><article class=" subNavAnchor fc_wrapper fc_image-left fc_image_mobile-imageFirst fc_title-section " id="landingpageparnew_featuredtextandimage" data-previewenabled="false"><div class=" fc_image fc_desktop-image fc_no-mobile-image"><div class=" fc__picture fc__picture--16-9-aspect-ratio "><a href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems/reaction-lab.html"><picture><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-640x360.jpg/_jcr_content/renditions/cq5dam.web.320.320.webp" media="(min-width: 0px) and (max-width: 320px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-640x360.jpg/_jcr_content/renditions/cq5dam.web.320.640.jpeg" media="(min-width: 0px) and (max-width: 320px)" type="image/jpeg"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-640x360.jpg/_jcr_content/renditions/cq5dam.web.480.480.webp" media="(min-width: 321px) and (max-width: 480px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-640x360.jpg/_jcr_content/renditions/cq5dam.web.480.800.jpeg" media="(min-width: 321px) and (max-width: 480px)" type="image/jpeg"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-640x360.jpg/_jcr_content/renditions/original.webp" media="(min-width: 481px) and (max-width: 640px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-640x360.jpg/_jcr_content/renditions/original.webp" media="(min-width: 641px) and (max-width: 800px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-640x360.jpg/_jcr_content/renditions/original.webp" media="(min-width: 801px)" type="image/webp"><img loading="lazy" loading="lazy" src="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-640x360.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="reaction lab software thumbnail" title="reaction lab software thumbnail"></picture></a></div></div><div class="fc_text-form"><div class="fc_text-wrap"><h2 class="fc_subtitle fc_subtitle-only ">Intelligently Design Reactions</h2><div class="fc_text text"><p><p>Optimize reactions faster, using fewer experiments</p><ul><li>Use mechanistic models to predict conditions that maximize yield and minimize impurities in synthetic organic processes</li><li>Quickly transform routinely collected process, PAT, and offline analytical data into kinetic models that enable greater reaction understanding with limited time and materials</li><li>Extract full value from data to provide critical guidance and speed development work</li><li>Gain insight into reaction mechanisms for deep reaction understanding that can be leveraged for optimal processing </li><li>Build confidence in scale-up using data-driven, prediction-based methodologies</li><li>Develop higher-performing, greener chemistry to contribute to sustainability goals</li></ul><p><a href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems/reaction-lab.html" _rte_href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems/reaction-lab.html">Learn more about Reaction Lab.</a></p></p></div></div></div></article></div></div><div class="featuredtextandimage section"><div class="cross-template-component "><article class=" subNavAnchor fc_wrapper fc_image-left fc_image_mobile-imageFirst fc__wrapper--textWrap fc_title-section " id="landingpageparnew_featuredtextandimage_1960453514" data-previewenabled="false"><div class=" fc_image fc_desktop-image fc_no-mobile-image"><div class=" fc__picture fc__picture--16-9-aspect-ratio "><a href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems/dynochem.html"><picture><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-2-640x360.jpg/_jcr_content/renditions/cq5dam.web.320.320.webp" media="(min-width: 0px) and (max-width: 320px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-2-640x360.jpg/_jcr_content/renditions/cq5dam.web.320.640.jpeg" media="(min-width: 0px) and (max-width: 320px)" type="image/jpeg"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-2-640x360.jpg/_jcr_content/renditions/cq5dam.web.480.480.webp" media="(min-width: 321px) and (max-width: 480px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-2-640x360.jpg/_jcr_content/renditions/cq5dam.web.480.800.jpeg" media="(min-width: 321px) and (max-width: 480px)" type="image/jpeg"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-2-640x360.jpg/_jcr_content/renditions/original.webp" media="(min-width: 481px) and (max-width: 640px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-2-640x360.jpg/_jcr_content/renditions/original.webp" media="(min-width: 641px) and (max-width: 800px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-2-640x360.jpg/_jcr_content/renditions/original.webp" media="(min-width: 801px)" type="image/webp"><img loading="lazy" loading="lazy" src="/dam/autochem/products/scale-up-suite/right-first-time-scale-up-2-640x360.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="dynochem scale-up" title="dynochem scale-up"></picture></a></div></div><div class="fc_text-form"><div class="fc_text-wrap"><h2 class="fc_subtitle fc_subtitle-only ">Right First Time Scale-Up </h2><div class="fc_text text"><p><p>Predict the performance of every unit operation before each campaign to ensure success on scale-up from lab to plant.</p><ul><li>Predict mixing effects on reactions and crystallizations at different scales and vessel types</li><li>Simplify and accelerate tech transfer and increase collaboration with manufacturing partners</li><li>Design safe processes by predicting key parameters such as time to maximum rate (TMR) and maximum temperature of synthesis reaction (MTSR)</li><li>Develop dynamic models for common chemical unit operations, such as reactions, solvent exchange distillation, extractions, filtrations, and drying, to gain process knowledge and enable effective scale-up and tech transfers</li><li>Access an extensive database of material properties for common solvents and chemicals</li><li>Quickly perform routine calculations through easy-to-use applications such as chemical equilibrium, mixing and heat transfer, process fit, and solubility prediction</li><li>Extensive library of ready-to-use simulation tools developed by industry experts, readily available to all users</li></ul><p><a href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems/dynochem.html" _rte_href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems/dynochem.html">Learn more about Dynochem.</a></p></p></div></div></div></article></div></div><div class="featuredtextandimage section"><div class="cross-template-component "><article class=" subNavAnchor fc_wrapper fc_image-left fc_image_mobile-imageFirst fc__wrapper--textWrap fc_title-section " id="landingpageparnew_featuredtextandimage_817612145" data-previewenabled="false"><div class=" fc_image fc_desktop-image fc_no-mobile-image"><div class=" fc__picture fc__picture--16-9-aspect-ratio "><a href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems/dynochem-biologics.html"><picture><source srcset="/dam/autochem/products/scale-up-suite/bioharvest-modeling-640x360.jpg/_jcr_content/renditions/cq5dam.web.320.320.webp" media="(min-width: 0px) and (max-width: 320px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/bioharvest-modeling-640x360.jpg/_jcr_content/renditions/cq5dam.web.320.640.jpeg" media="(min-width: 0px) and (max-width: 320px)" type="image/jpeg"><source srcset="/dam/autochem/products/scale-up-suite/bioharvest-modeling-640x360.jpg/_jcr_content/renditions/cq5dam.web.480.480.webp" media="(min-width: 321px) and (max-width: 480px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/bioharvest-modeling-640x360.jpg/_jcr_content/renditions/cq5dam.web.480.800.jpeg" media="(min-width: 321px) and (max-width: 480px)" type="image/jpeg"><source srcset="/dam/autochem/products/scale-up-suite/bioharvest-modeling-640x360.jpg/_jcr_content/renditions/original.webp" media="(min-width: 481px) and (max-width: 640px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/bioharvest-modeling-640x360.jpg/_jcr_content/renditions/original.webp" media="(min-width: 641px) and (max-width: 800px)" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/bioharvest-modeling-640x360.jpg/_jcr_content/renditions/original.webp" media="(min-width: 801px)" type="image/webp"><img loading="lazy" loading="lazy" src="/dam/autochem/products/scale-up-suite/bioharvest-modeling-640x360.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="bioprocess scale-up" title="bioprocess scale-up"></picture></a></div></div><div class="fc_text-form"><div class="fc_text-wrap"><h2 class="fc_subtitle fc_subtitle-only ">Bioprocess Modeling at Any Scale </h2><div class="fc_text text"><p><p>Enable process characterization across typical upstream and downstream unit operations</p><ul><li>Mixing calculation tools help scale from lab reactors such as Ambr® 15, shake flasks, vials, and rocked/wave bags to stirred tank reactors</li><li>Ensure adequate mixing without excessive shear in operations ranging from media development/prep to UF/DF, avoiding batch failures and yield loss</li><li>Develop bioreactor models to support the prediction of glucose and DO levels, pH, and titer at each scale, leveraging mixing tools to ensure uniform spatial distribution</li><li>Downstream capabilities include models for disk-stack centrifugation, depth filtration, chromatography, virus inactivation, conjugation, tangential flow filtration (TFF), and diafiltration, including the design of mixing set-ups</li><li>Fill/finish tools leverage predictions of lyophilization (primary and secondary drying) in vials, including prevention of meltback/collapse, and ensure adequate mixing of excipients</li></ul><p><a href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems/dynochem-biologics.html" _rte_href="/ch/en/home/products/L1_AutochemProducts/scale-up-systems/dynochem-biologics.html">Learn more about Dynochem Biologics.</a></p></p></div></div></div></article></div></div><div class="benefitsselling section"><link rel="stylesheet" href="/etc.clientlibs/mt/components/content/benefitsselling/clientlib.min-v55.css" type="text/css"><div class="cross-template-component"><div class="benefitsSelling__wrapper"><div class="benefitsSelling__title subNavAnchor" id="landingpageparnew_benefitsselling_copy"><h2 class="emphasisSecondary">Case Studies from Industry</h2></div><div class="benefitsSelling benefitsSelling--3column"><div class="benefitsSelling__benefit benefitsSelling__benefits1"><a href="/ch/en/home/library/on-demand-webinars/automated-reactors/crawford-mk-1026-nemtabrutinib-msd.html" class="benefitsSelling__benefit__link"><div class="benefit__image"><picture><source srcset="/dam/autochem/products/scale-up-suite/msd-logo-286x191.jpg/_jcr_content/renditions/cq5dam.web.240.240.webp" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/msd-logo-286x191.jpg/_jcr_content/renditions/cq5dam.web.240.480.jpeg" type="image/jpeg"><img loading="lazy" src="/dam/autochem/products/scale-up-suite/msd-logo-286x191.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" class="benefit__picture__img"></picture></div><div class="benefit__text"> Data-Driven Reaction Models in Late-Stage Pharmaceutical Process Development </div></a></div><div class="benefitsSelling__benefit benefitsSelling__benefits2"><a href="/ch/en/home/library/on-demand-webinars/automated-reactors/delany-ftir-kinetics-study.html" class="benefitsSelling__benefit__link"><div class="benefit__image"><picture><source srcset="/dam/autochem/products/scale-up-suite/apc-logo-286x191.jpg/_jcr_content/renditions/cq5dam.web.240.240.webp" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/apc-logo-286x191.jpg/_jcr_content/renditions/cq5dam.web.240.480.jpeg" type="image/jpeg"><img loading="lazy" src="/dam/autochem/products/scale-up-suite/apc-logo-286x191.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" class="benefit__picture__img"></picture></div><div class="benefit__text"> How Reaction Lab Can Compensate for a Weaker Background in Reaction Kinetics </div></a></div><div class="benefitsSelling__benefit benefitsSelling__benefits3"><a href="/ch/en/home/library/on-demand-webinars/automated-reactors/rueger-accelerate-biopharma-process-development.html" class="benefitsSelling__benefit__link"><div class="benefit__image"><picture><source srcset="/dam/autochem/products/scale-up-suite/millipore-logo-286x191.jpg/_jcr_content/renditions/cq5dam.web.240.240.webp" type="image/webp"><source srcset="/dam/autochem/products/scale-up-suite/millipore-logo-286x191.jpg/_jcr_content/renditions/cq5dam.web.240.480.jpeg" type="image/jpeg"><img loading="lazy" src="/dam/autochem/products/scale-up-suite/millipore-logo-286x191.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" class="benefit__picture__img"></picture></div><div class="benefit__text"> PAT and Model-Based Approach to Accelerate Biopharma Process Development </div></a></div></div></div></div></div><div class="matchingblockcarousel section"><div class="mbcarousel cross-template-component"><div class="mbcarousel_title-wrap subNavAnchor" id="landingpageparnew_matchingblockcarousel"><h2 class="mbcarousel_title ">Scale-up Related Resources</h2></div><link rel="stylesheet" href="/etc.clientlibs/mt/components/content/matchingblockcarousel/clientlib-shared.min-v55.css" type="text/css"><link rel="stylesheet" href="/etc.clientlibs/mt/components/content/matchingblockcarousel/clientlib-carousel.min-v55.css" type="text/css"><script src="/etc.clientlibs/mt/components/content/matchingblockcarousel/clientlib-carousel.min-v55.js"></script> <div class="mbcarousel_wrapper mbWhite mbSquare" data-mbcarouselslides="0" data-iseditmode="false"><div class="mbcarousel_slide " data-path="/content/ch/en/home/library/on-demand-webinars/automated-reactors/hallow-green-solvent-swap-distillation"><div class="mbcarousel_slide-flex-wrap"><div class="mbcarousel_slide-image "><a href="/ch/en/home/library/on-demand-webinars/automated-reactors/hallow-green-solvent-swap-distillation.html"><picture><source srcset="/dam/autochem/library/on-demand-webinars/odw-thumbnails/2023/hallow-green-solvent-swap-distillation-1920x1080.jpg/_jcr_content/renditions/cq5dam.web.320.320.webp" type="image/webp"><source srcset="/dam/autochem/library/on-demand-webinars/odw-thumbnails/2023/hallow-green-solvent-swap-distillation-1920x1080.jpg/_jcr_content/renditions/cq5dam.web.320.640.jpeg" type="image/jpeg"><img loading="lazy" src="/dam/autochem/library/on-demand-webinars/odw-thumbnails/2023/hallow-green-solvent-swap-distillation-1920x1080.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="Green Solvent Swap Distillation" title="Green Solvent Swap Distillation"></picture></a></div><div class="mbcarousel_slide-text"><h3 class="mbcarousel_slide-title"><a href="/ch/en/home/library/on-demand-webinars/automated-reactors/hallow-green-solvent-swap-distillation.html">Webinar: Green Solvent Swap Distillation</a></h3><p class="mbcarousel_slide-subtitle"> Solvent swaps are common operations within a synthetic step to setup the following reaction, extract... </p></div></div></div><div class="mbcarousel_slide " data-path="/content/ch/en/home/library/on-demand-webinars/automated-reactors/Understanding-Scale-up-Risks-in-Early-Stage-Process-Development-Urs-Groth"><div class="mbcarousel_slide-flex-wrap"><div class="mbcarousel_slide-image "><a href="/ch/en/home/library/on-demand-webinars/automated-reactors/Understanding-Scale-up-Risks-in-Early-Stage-Process-Development-Urs-Groth.html"><picture><img loading="lazy" src="/ch/en/home/library/on-demand-webinars/automated-reactors/Understanding-Scale-up-Risks-in-Early-Stage-Process-Development-Urs-Groth/_jcr_content/smallImage.webImage.file.png" alt="Process Development Heat Flow Data" title="Process Development Heat Flow Data"></picture></a></div><div class="mbcarousel_slide-text"><h3 class="mbcarousel_slide-title"><a href="/ch/en/home/library/on-demand-webinars/automated-reactors/Understanding-Scale-up-Risks-in-Early-Stage-Process-Development-Urs-Groth.html">Understanding Scale-up Risks in Early-Stage Process Development</a></h3><p class="mbcarousel_slide-subtitle"> A best practice during process development involves understanding safety risks associated with a che... </p></div></div></div><div class="mbcarousel_slide " data-path="/content/ch/en/home/library/white-papers/automated-reactors/crystals"><div class="mbcarousel_slide-flex-wrap"><div class="mbcarousel_slide-image "><a href="/ch/en/home/library/white-papers/automated-reactors/crystals.html"><picture><source srcset="/dam/non-indexed/po/autochem/whitepapers/scale-up-of-batch-crystallization-lab-to-plant/scaleup-crystallization-300x300.png/_jcr_content/renditions/cq5dam.web.240.240.webp" type="image/webp"><img loading="lazy" src="/dam/non-indexed/po/autochem/whitepapers/scale-up-of-batch-crystallization-lab-to-plant/scaleup-crystallization-300x300.png/_jcr_content/renditions/cq5dam.web.1280.1280.png" alt="Scale-up of Batch Crystallization From Lab to Plant" title="Scale-up of Batch Crystallization From Lab to Plant"></picture></a></div><div class="mbcarousel_slide-text"><h3 class="mbcarousel_slide-title"><a href="/ch/en/home/library/white-papers/automated-reactors/crystals.html">Batch Crystallizer Scale-Up and Design</a></h3><p class="mbcarousel_slide-subtitle"> Scale-up of crystallization is notoriously complicated and companies are under pressure to develop s... </p></div></div></div><div class="mbcarousel_slide " data-path="/content/ch/en/home/library/white-papers/automated-reactors/establishing-safe-unattended-dosing-for-chemical-development-and"><div class="mbcarousel_slide-flex-wrap"><div class="mbcarousel_slide-image "><a href="/ch/en/home/library/white-papers/automated-reactors/establishing-safe-unattended-dosing-for-chemical-development-and.html"><picture><source srcset="/dam/direct-upload/thumbnails/library/white-papers/automated-reactors/establishing-safe-unattended-dosing-for-chemical-development-and/unattended-dosing-300x300.png/_jcr_content/renditions/cq5dam.web.240.240.webp" type="image/webp"><img loading="lazy" src="/dam/direct-upload/thumbnails/library/white-papers/automated-reactors/establishing-safe-unattended-dosing-for-chemical-development-and/unattended-dosing-300x300.png/_jcr_content/renditions/cq5dam.web.1280.1280.png" alt="Dosing in Chemical Development" title="Dosing in Chemical Development"></picture></a></div><div class="mbcarousel_slide-text"><h3 class="mbcarousel_slide-title"><a href="/ch/en/home/library/white-papers/automated-reactors/establishing-safe-unattended-dosing-for-chemical-development-and.html">Safe, Unattended Dosing in Chemical Development & Scale-up</a></h3><p class="mbcarousel_slide-subtitle"> Grünenthal Process R&D safely automates dosing and runs highly exothermic reactions unattended to in... </p></div></div></div><div class="mbcarousel_slide " data-path="/content/ch/en/home/library/on-demand-webinars/automated-reactors/Lubrizol-Uses-Efficient-Scale-Up-Process-Control"><div class="mbcarousel_slide-flex-wrap"><div class="mbcarousel_slide-image "><a href="/ch/en/home/library/on-demand-webinars/automated-reactors/Lubrizol-Uses-Efficient-Scale-Up-Process-Control.html"><picture><img loading="lazy" src="/ch/en/home/library/on-demand-webinars/automated-reactors/Lubrizol-Uses-Efficient-Scale-Up-Process-Control/_jcr_content/smallImage.webImage.file.png" alt="Lubrizol Process Development and Scale-up" title="Lubrizol Process Development and Scale-up"></picture></a></div><div class="mbcarousel_slide-text"><h3 class="mbcarousel_slide-title"><a href="/ch/en/home/library/on-demand-webinars/automated-reactors/Lubrizol-Uses-Efficient-Scale-Up-Process-Control.html">Lubrizol's Efficient Scale-Up & Process Control</a></h3><p class="mbcarousel_slide-subtitle"> This webinar focuses on how to improve process development and scale-up by leveraging calorimetry an... </p></div></div></div><div class="mbcarousel_slide " data-path="/content/ch/en/home/library/white-papers/automated-reactors/Effective-Design-of-Experiment-Studies"><div class="mbcarousel_slide-flex-wrap"><div class="mbcarousel_slide-image "><a href="/ch/en/home/library/white-papers/automated-reactors/Effective-Design-of-Experiment-Studies.html"><picture><img loading="lazy" src="/dam/direct-upload/thumbnails/library/white-papers/automated-reactors/Effective-Design-of-Experiment-Studies/fast-doe-studies-300x300.png/_jcr_content/renditions/cq5dam.web.1280.1280.png" alt="Effective Design of Experiment Studies" title="Effective Design of Experiment Studies"></picture></a></div><div class="mbcarousel_slide-text"><h3 class="mbcarousel_slide-title"><a href="/ch/en/home/library/white-papers/automated-reactors/Effective-Design-of-Experiment-Studies.html">Effective Design of Experiment Studies</a></h3><p class="mbcarousel_slide-subtitle"> This paper describes the Design of Experiments (DoE) approach and how it is used to identify the rel... </p></div></div></div></div></div></div><div class="featuredtextandimage section"><div class="cross-template-component "><article class=" subNavAnchor fc_wrapper fc_image-right fc_image_mobile-imageFirst fc_title-section " id="landingpageparnew_featuredtextandimage_1907785087" data-previewenabled="false"><div class="fc_text-form"><div class="fc_text-wrap"><h2 class="fc_subtitle fc_subtitle-only ">Sustainable Development with Scale-up Suite</h2><div class="fc_text text"><p><p>METTLER TOLEDO is committed to not only maintaining carbon neutrality for our operations but also to establishing science-based targets to drive an absolute reduction of greenhouse gas emissions across our operations and supply chain. Scale-up Suite enables you to design processes that use less raw materials, generate less waste, and require less energy for a more efficient, high-performing process.</p></p></div></div><div class="fc_feedback-btn-wrap fc_feedback-btn-secondary"><div class="feedbackb"><div class="fbB_formView fb_standard_view_featuredtextandimage_1907785087_feedbackb"><div id="fbB_introBtnText_table_featuredtextandimage_1907785087_feedbackb"><form method="get" action="/ch/en/home/products/L1_AutochemProducts/scale-up-systems.fb.landingpageparnew.featuredtextandimage_1907785087.feedbackb.html" style="display:inline-block;"><button class="fb-button-p5a btn-action btn-primary btn-large" data-aa-catId="13" aria-label="Request More Information"><span> Request More Information </span></button></form></div></div></div></div></div><div class=" fc_image fc_desktop-image fc_no-mobile-image"><div class=" fc__picture fc__picture--16-9-aspect-ratio "><picture><source srcset="/dam/direct-upload/image_asset_migration/products/L1_AutochemProducts/scale-up-systems/image-webimage-file-png/_jcr_content/renditions/cq5dam.web.320.320.webp" media="(min-width: 0px) and (max-width: 320px)" type="image/webp"><source srcset="/dam/direct-upload/image_asset_migration/products/L1_AutochemProducts/scale-up-systems/image-webimage-file-png/_jcr_content/renditions/cq5dam.web.480.480.webp" media="(min-width: 321px) and (max-width: 480px)" type="image/webp"><source srcset="/dam/direct-upload/image_asset_migration/products/L1_AutochemProducts/scale-up-systems/image-webimage-file-png/_jcr_content/renditions/original.webp" media="(min-width: 481px) and (max-width: 640px)" type="image/webp"><source srcset="/dam/direct-upload/image_asset_migration/products/L1_AutochemProducts/scale-up-systems/image-webimage-file-png/_jcr_content/renditions/original.webp" media="(min-width: 641px) and (max-width: 800px)" type="image/webp"><source srcset="/dam/direct-upload/image_asset_migration/products/L1_AutochemProducts/scale-up-systems/image-webimage-file-png/_jcr_content/renditions/original.webp" media="(min-width: 801px)" type="image/webp"><img loading="lazy" loading="lazy" src="/dam/direct-upload/image_asset_migration/products/L1_AutochemProducts/scale-up-systems/image-webimage-file-png" alt="GreenMT framework" title="GreenMT framework"></picture></div></div></article></div></div><div class="simplefaq section"><link rel="stylesheet" href="/etc/designs/mt/widgets/misc/simplefaq.min-v55.css" type="text/css"><script defer src="/etc/designs/mt/widgets/misc/simplefaq.min-v55.js"></script> <div class="cross-template-component"><div class="simple-faq"><div class="simple-faq_title-wrap subNavAnchor" id="landingpageparnew_simplefaq"><h2 class="simple-faq_title-text emphasisSecondary">Scale-up Suite FAQ</h2></div><div class="simple-faq_wrapper" data-iseditmode="false"><div class="simple-faq_item active"><div class="simpleFaqQuestion1 simplefaqquestion"><div class="simple-faq-question_wrapper " data-iseditmode="false"><div class="simple-faq-question_header-text-wrap"><h3 class="simple-faq-question_header-text">Is Scale-up Systems the same company as METTLER TOLEDO?</h3><div class="simple-faq-question_header-arrow"></div></div><div class="simple-faq-question_answer-wrap simple-faq-question_text"><div class="answer simplefaqtext"><div class=" fc_wrapper " id="fc_wrapper-096f4d14-a267-491e-a739-38b1af72128d" data-previewenabled="false"><div class="fc_text-form"><div class="fc_text-wrap"><div class="fc_text text"><p><p>As of Friday, October 1st, 2021 Scale-up Systems has become part of the METTLER TOLEDO Group. Our organization will join the METTLER TOLEDO AutoChem business that is serving many of the same customers in the pharmaceutical industry. We are excited about the opportunities this important step in our company history presents.</p><p>The combination of our widely used Scale-up Suite™ process development and scale-up software with METTLER TOLEDO's market-leading products and services for biological and chemical process development creates the most comprehensive offerings for these important applications in the pharmaceutical and chemical industry.</p><p>We are committed to continuing to deliver the excellent products and customer support that our customers have come to expect from Scale-up Systems and look forward to adding the global strengths of METTLER TOLEDO.</p></p></div></div></div></div></div></div></div></div></div><div class="simple-faq_item"><div class="simpleFaqQuestion2 simplefaqquestion"><div class="simple-faq-question_wrapper " data-iseditmode="false"><div class="simple-faq-question_header-text-wrap"><h3 class="simple-faq-question_header-text">What is process scale-up and tech transfer? </h3><div class="simple-faq-question_header-arrow"></div></div><div class="simple-faq-question_answer-wrap simple-faq-question_text"><div class="answer simplefaqtext"><div class=" fc_wrapper " id="fc_wrapper-fba64236-92e3-4f74-80af-7350a0aa6e2d" data-previewenabled="false"><div class="fc_text-form"><div class="fc_text-wrap"><div class="fc_text text"><p><p>Process scale-up generally refers to increasing the production capacity by operating a chemical process in larger equipment. For example, transferring a process from the lab scale to a pilot plant or from a pilot plant to a full-scale manufacturing plant. Transferring a process across scales will often impact the physical rates in the synthesis, such as mixing, heat transfer, and mass transfer. Understanding the impact of these rates on a process is critical to designing the process to operate efficiently and robustly while producing quality products at new scales.</p><p>Transferring a process into new equipment or sites is generally referred to as a technology transfer (tech transfer) and may involve scale-up, scale-down, or scale-neutral transitions. Our process modeling software in the Scale-up Suite provides an easy-to-use and comprehensive platform for making calculations and performing simulations that can account for the physical rates, ensuring a right first time scale-up and successful tech transfer.</p></p></div></div></div></div></div></div></div></div></div><div class="simple-faq_item"><div class="simpleFaqQuestion3 simplefaqquestion"><div class="simple-faq-question_wrapper " data-iseditmode="false"><div class="simple-faq-question_header-text-wrap"><h3 class="simple-faq-question_header-text">What is the scale-up process?</h3><div class="simple-faq-question_header-arrow"></div></div><div class="simple-faq-question_answer-wrap simple-faq-question_text"><div class="answer simplefaqtext"><div class=" fc_wrapper " id="fc_wrapper-913a43cf-c109-495e-94c2-bdaec9035341" data-previewenabled="false"><div class="fc_text-form"><div class="fc_text-wrap"><div class="fc_text text"><p><p>As a chemical process is developed, more material must be produced to eventually achieve commercial production demands. Often, a chemical process is scaled up several times, over orders of magnitude, from small lab bench scale to medium pilot plant facilities to large full-scale manufacturing plants.</p><p>New pharmaceuticals frequently require several scale-ups due to the increasing demands of pre-clinical studies and clinical trials before regulatory approval of the manufacturing process. Achieving quality material at expected yields when transferring a process (right first time) is important to accelerate the development of new processes and the pace of products reaching the market. Our process modeling software in the Scale-up Suite enables you to achieve these goals and accelerate process development while dealing with increasingly complex processes.</p></p></div></div></div></div></div></div></div></div></div><div class="simple-faq_item"><div class="simpleFaqQuestion4 simplefaqquestion"></div></div><div class="simple-faq_item"><div class="simpleFaqQuestion5 simplefaqquestion"></div></div></div></div></div><script type="application/ld+json"> { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Is Scale-up Systems the same company as METTLER TOLEDO?", "acceptedAnswer": { "@type": "Answer", "text": "As of Friday, October 1st, 2021 Scale-up Systems has become part of the METTLER TOLEDO Group. Our organization will join the METTLER TOLEDO AutoChem business that is serving many of the same customers in the pharmaceutical industry. 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Our process modeling software in the Scale-up Suite enables you to achieve these goals and accelerate process development while dealing with increasingly complex processes." } } ] } </script> </div></div></div><div class="back-to-top-wrapper"><a href="#header_layer_wrapper" class="back-to-top-link" aria-label="Scroll to Top"></a></div></div></div></div><link rel="stylesheet" href="/etc/designs/mt/widgets/misc/mtsitefooter.min-v55.css" type="text/css"><footer id="footer_layer" class="footerLayer landingpage2021"><div class="top_meta_layer mobile_country_selection"></div><div class="clear"></div><div class="inheritedFooterParsys parsys"><link rel="stylesheet" href="/etc/designs/mt/widgets/misc/columncontrolbase.min-v55.css" type="text/css"><link rel="stylesheet" href="/etc/designs/mt/widgets/misc/columncontrolcolumns/column-5.min-v55.css" type="text/css"><link rel="stylesheet" href="/etc/designs/mt/widgets/misc/columncontrolpadding/padding-10.min-v55.css" type="text/css"><div 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