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Conference Day 1 2024 - Peptide Based Therapeutics Summit

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</div> </div> <div class="fl-col-group fl-node-5cf92206cc4d8" data-node="5cf92206cc4d8"> <div class="fl-col fl-node-5cf92206cc5c2 fl-col-bg-color" data-node="5cf92206cc5c2"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-5ba1fe150afaa fl-visible-desktop fl-visible-large fl-visible-medium" data-node="5ba1fe150afaa"> <div class="fl-module-content fl-node-content"> <h3 class="fl-heading"> <span class="fl-heading-text">April 1-3, 2025 | Boston, MA</span> </h3> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-gjw0a31drlho" data-node="gjw0a31drlho"> <div class="fl-col fl-node-rxcomvf1k4te fl-col-bg-color" data-node="rxcomvf1k4te"> <div class="fl-col-content fl-node-content"></div> </div> </div> <div class="fl-col-group fl-node-pe4tsbjlv9wu" data-node="pe4tsbjlv9wu"> <div class="fl-col fl-node-8ofxba7ecs9v fl-col-bg-color" data-node="8ofxba7ecs9v"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-button fl-node-fl3huymsxzbo" data-node="fl3huymsxzbo"> <div class="fl-module-content fl-node-content"> <div class="fl-button-wrap fl-button-width-custom fl-button-right fl-button-has-icon"> <a href="https://peptide-based-therapeutics-summit.com/whats-on/full-event-guide/" target="_self" class="fl-button fl-button-icon-animation"> <span class="fl-button-text">VIEW FULL EVENT GUIDE</span> <i class="fl-button-icon fl-button-icon-after fas fa-arrow-right" aria-hidden="true"></i> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </header> <div id="fl-main-content" class="fl-page-content" itemprop="mainContentOfPage" role="main"> <div class="fl-content-full container"> <div class="row"> <div class="fl-content col-md-12"> <article class="fl-post post-595 page type-page status-publish has-post-thumbnail hentry" id="fl-post-595" itemscope="itemscope" itemtype="https://schema.org/CreativeWork"> <div class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-595 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="595"><div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-7950jvg3w8a6 fl-row-default-height fl-row-align-center" data-node="7950jvg3w8a6"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-scqkf6uxv8o2" data-node="scqkf6uxv8o2"> <div class="fl-col fl-node-24gfet0kp9x1 fl-col-bg-color fl-col-small" data-node="24gfet0kp9x1"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-link fl-node-5bb333f298e9c" data-node="5bb333f298e9c"> <div class="fl-module-content fl-node-content"> <a href="https://peptide-based-therapeutics-summit.com/about/agenda/day-one/" id="ee-link-5bb333f298e9c"> <div class="eehw-link"> <div class="link-url"> <h2>Day One</h2> </div> <div class="link-date"> <p>Wednesday April 24 </p> </div> </div> </a> </div> </div> </div> </div> <div class="fl-col fl-node-8vcbawp6h51e fl-col-bg-color fl-col-small" data-node="8vcbawp6h51e"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-link fl-node-5bb333cc51b0a" data-node="5bb333cc51b0a"> <div class="fl-module-content fl-node-content"> <a href="https://peptide-based-therapeutics-summit.com/about/agenda/day-two/" id="ee-link-5bb333cc51b0a"> <div class="eehw-link"> <div class="link-url"> <h2>Day Two</h2> </div> <div class="link-date"> <p>Thursday April 25</p> </div> </div> </a> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-hxz1y8ap3dql" data-node="hxz1y8ap3dql"> <div class="fl-col fl-node-vohfgki610ey fl-col-bg-color" data-node="vohfgki610ey"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-ie80qdrjlzkm" data-node="ie80qdrjlzkm"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 7:45 am </span> <b><span style="color:#38ACE1">Check in &#038; Refreshments</b></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:45 am </span> Chair&#8217;s Opening Remarks </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #cee1e9"> <h3> <span class="time"> </span> <b><center><span style="color:#242F73">Uncovering the Latest Technology for Advancing the Peptide Therapeutics Field</b></center></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:00 am </span> Peptide Drug Hunting: Entrepreneurial Science &#038; Technologies Empowering Breakthrough Medicines </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22181" class="view-speaker" speaker-id="22181"><span>Tomi Sawyer</span></a></em> Chief Drug Hunter & President, Maestro Therapeutics </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• High level overview of peptide drug discovery and current lead identification strategies </p> <p>• Peptide lead optimization integrating structural biology and computational chemistry </p> <p>• Examples of peptide drug development with potential to be breakthrough medicines </p> <p>• Creation of a worldwide entrepreneurial consortium for peptide drug hunting</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:30 am </span> Exploring Advances in Screening Platforms to Propel Forward Discovery </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22113" class="view-speaker" speaker-id="22113"><span>Hiroaki Suga</span></a></em> Professor, PeptiDream & University of Tokyo </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Delving into the science and success behind the PeptiDream platform </p> <p>• Optimization process for orally available macrocyclic peptides </p> <p>• Future development of peptide-drug conjugates and multi-functional peptide conjugates</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:00 am </span> WuXi AppTec&#8217;s DEL Technology for DIscovering Peptides with Improved Stability &#038; Cell Permeability </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22529" class="view-speaker" speaker-id="22529"><span>Jason Deng</span></a></em> Senior Director, DEL Biology & Screen, WuXi AppTec </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Peptide therapeutics are emerging as viable treatments for traditionally difficult-to-drug targets, though discovery methods like phage and mRNA display face limitations such as low stability and poor cell penetration.</li> <li>WuXi AppTec&#39;s DEL technology overcomes these issues by enabling the integration of unnatural amino acids into vast peptide libraries, thereby improving their stability and cell permeability.</li> <li>DEL-derived libraries have produced cyclic peptides with strong inhibitory effects on the MDM2−p53 interaction, leading to valuable insights for enhancing drug properties.</li> <li>The technology has also identified PCSK9 binding peptides, offering a promising route for novel cholesterol-lowering drugs, and tumor-specific ligands for targeted drug delivery applications.</li> </ul> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:30 am </span> <b><span style="color:#38ACE1">Morning Break &#038; Speed Networking</b></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>The ideal opportunity to get face-to-face with many of the brightest minds working in the peptide field and introduce yourself to the attendees that you would like to have more in-depth conversations with</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 11:30 am </span> Developing Oral Peptide Therapeutics at the Speed of Light </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22114" class="view-speaker" speaker-id="22114"><span>Pete Gough</span></a></em> chief scientific officer, Nimble Therapeutics </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Describing our platform technology and how it enables custom synthesis of greater than 100 million peptides overnight</p> <p>• Examples of how we have used our platform to optimize properties of peptide therapeutics</p> <p>• Highlights of our internal oral peptide therapeutics discovery programs</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 12:00 pm </span> Exploring Vivtex’s Robotic Screening Platform for Optimizing the Delivery of Oral Peptides </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22115" class="view-speaker" speaker-id="22115"><span>Thomas von Erlach</span></a></em> Co-Founder & Chief Scientific Officer, Vivtex </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Background behind Vivtex’s approach to developing orally administered peptides with high GI absorption</p> <p>• Understanding the scientific rationale underlying Vivtex’s GI Tract-Tissue Robotic Interface System (GI-TRIS)</p> <p>• Case studies detailing the use of this screening system to facilitate oral peptide delivery</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 12:30 pm </span> <b><span style="color:#38ACE1">Lunch &#038; Networking</b></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #cee1e9"> <h3> <span class="time"> </span> <b><center><span style="color:#242F73">Advances in Applications for Peptide-Based Therapeutics &#8211; Exploring Their Untapped Potential</b></center></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 1:30 pm </span> RapaGlues &#8211; A Bridge between Macrocyclic Peptides and Molecular Glues for Interrogating Hard to Drug Targets </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22536" class="view-speaker" speaker-id="22536"><span>Rick Ewing</span></a></em> Vice President and Head of Chemistry, Rapafusyn Pharmaceuticals </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Our construction of DEL and array libraries of molecular glues will be discussed as well as our perspectives on accessing topological diversity.</li> <li>Screening of the platform has yielded chemical starting points have been discovered for several target classes. One program will described SAR leading to potent, cell permeable macrocycles for the inhibition of an oncology target.  </li> <li>Our platform has yielded a development candidate for the prevention of acute kidney injury. The biological rationale and characterization of this candidate will be shown, both in vitro and in vivo efficacy data.</li> </ul> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:00 pm </span> Novel BBB-Surpassing Peptide Structure for Unlocking New Treatment Avenues </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22183" class="view-speaker" speaker-id="22183"><span>Andy Slee</span></a></em> Chief Scientific Officer, Protagenic Therapeutics </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Developing peptide-based drugs for the treatment of affective disorders</li> <li>Peptides derived from natural genomic sequences with low toxicity and the ability to surpass the blood-brain-barrier</li> <li>Exploring PTIs lead compound, PT00114, which is currently in clinical trials</li> </ul> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:30 pm </span> <b><span style="color:#38ACE1">Afternoon Break &#038; Scientific Poster Session</b></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>This is an informal session to help you connect with your peers in a relaxed atmosphere and forge new and beneficial relationships. With an audience of peptide experts eager to hear the latest innovations and positive movement, you will have the opportunity to display a poster presenting your own work. Additionally, you will have the chance to review others’ posters displaying cutting-edge work from drug discovery right through to exciting clinical trial updates.</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #cee1e9"> <h3> <span class="time"> </span> <b><center><span style="color:#242F73">Exploring the Recent Clinical Successes Within Peptide Based Therapeutics to Drive Forward Future Success on Novel Targets</b></center></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:30 pm </span> Uncovering the Discovery of FOG-001, a First-And-Only-In-Class Direct B-Catenin Inhibiting Peptide </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22549" class="view-speaker" speaker-id="22549"><span>Jonathan Hurov</span></a></em> Executive Vice President - Discovery Biology, Fog Pharma </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:00 pm </span> Discovery of Zilucoplan: A Peptide Complement C5 Inhibitor in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22117" class="view-speaker" speaker-id="22117"><span>Ping Ye</span></a></em> Senior Scientist, UCB </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Brief introduction of UCB and origin of zilucoplan</p> <p>• Examining the biology background and early discovery of zilucoplan &#8211; a small, subcutaneously administered, macrocyclic peptide</p> <p>• Discussing lessons learnt from this clinical success and future directions</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:30 pm </span> Chair’s Closing Remarks </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:30 pm </span> <b><span style="color:#38ACE1">Post-Conference Drinks Reception</b></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-xaqgz1cwobi7" data-node="xaqgz1cwobi7"> <div 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mouseleave');this._menuOnClick();this._clickOrHover();}else{$(this.wrapperClass).off('click');this._submenuOnRight();this._submenuRowZindexFix();} if(this.mobileToggle!='expanded'){this._toggleForMobile();} if($(this.wrapperClass).find('.fl-menu-search-item').length){this._toggleMenuSearch();} if($(this.wrapperClass).find('.fl-menu-cart-item').length){this._wooUpdateParams();}},_setupSubmenu:function(){$(this.wrapperClass+' ul.sub-menu').each(function(){$(this).closest('li').attr('aria-haspopup','true');});},_menuOnFocus:function(){var cKey=0,isShifted=false;$(this.nodeClass).off('keydown').on('keydown','a',function(e){cKey=e.which;isShifted=e.shiftKey;});$(this.nodeClass).off('focus').on('focus','a',$.proxy(function(e){var $menuItem=$(e.target).parents('.menu-item').first(),$parents=$(e.target).parentsUntil(this.wrapperClass);$('.fl-menu .focus').removeClass('focus');$parents.addClass('focus') if(!$menuItem.closest('.fl-has-submenu').hasClass('escaped')){$menuItem.addClass('focus')} else{$menuItem.closest('.fl-has-submenu').removeClass('focus escaped')}},this)).on('focusout','a',$.proxy(function(e){var el=$(e.target).parent(),$megaMenu=el.closest('.mega-menu'),$megaLastItem=$megaMenu.find('> .sub-menu > .menu-item:last-child'),$lastItem=el.parents('.fl-has-submenu:last').find('.menu-item:last'),isLastChild=!$megaMenu.length&&el.is($lastItem);if($megaMenu.length){isLastChild=el.is($megaLastItem)||el.is($megaLastItem.find('.menu-item:last-child'));} if(isLastChild&&cKey===9&&isShifted){isLastChild=false;cKey=0;isShifted=false;} else if(cKey===27){isLastChild=false;} if(isLastChild){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_menuOnEscape:function(){$('body').off('keydown').on('keydown',$.proxy(function(e){if(e.which!==27){return;} if($(e.target).closest('.menu-item').length){var activeSubmenu=null,menuItem=$(e.target).closest('.menu-item'),type=menuItem.closest('.fl-menu-accordion').length?'accordion':'horizontal';if('horizontal'===type){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('focus')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} else{$('.fl-menu').find('li.menu-item.focus').last().removeClass('focus');}},this));},_menuOnClick:function(){$(this.wrapperClass).off().on('click','.fl-has-submenu-container',$.proxy(function(e){var $link=$(e.target).parents('.fl-has-submenu').first(),$subMenu=$link.children('.sub-menu').first(),$href=$link.children('.fl-has-submenu-container').first().find('> a').attr('href'),$subMenuParents=$(e.target).parents('.sub-menu'),$activeParents=$(e.target).parents('.fl-has-submenu.fl-active');if(!$subMenu.is(':visible')||$(e.target).hasClass('fl-menu-toggle')||($subMenu.is(':visible')&&(typeof $href==='undefined'||$href=='#'))){e.preventDefault();} else{e.stopPropagation();window.location.href=$href;return;} if($(this.wrapperClass).hasClass('fl-menu-accordion-collapse')){if(!$link.parents('.menu-item').hasClass('fl-active')){$('.menu .fl-active',this.wrapperClass).not($link).removeClass('fl-active');} else if($link.parents('.menu-item').hasClass('fl-active')&&$link.parent('.sub-menu').length){$('.menu .fl-active',this.wrapperClass).not($link).not($activeParents).removeClass('fl-active');} $('.sub-menu',this.wrapperClass).not($subMenu).not($subMenuParents).slideUp('normal');} if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var $wrapper=null,$menu=null,self=this;if(this._isMenuToggle()){if(this._isMobileBelowRowEnabled()){this._placeMobileMenuBelowRow();$wrapper=$(this.wrapperClass);$menu=$(this.nodeClass+'-clone');$menu.find('ul.menu').show();} else{$wrapper=$(this.wrapperClass);$menu=$wrapper.find('.menu');} if(!$wrapper.find('.fl-menu-mobile-toggle').hasClass('fl-active')&&!self.mobileFlyout){$menu.css({display:'none'});} if(self.mobileFlyout){this._initFlyoutMenu();} $wrapper.on('click','.fl-menu-mobile-toggle',function(e){$(this).toggleClass('fl-active');if(self.mobileFlyout){self._toggleFlyoutMenu();} else{var targetMenu=null;if(self.mobileBelowRow){targetMenu=$(this).closest('.fl-col').next('.fl-menu-mobile-clone');}else{targetMenu=$(this).closest('.fl-menu').find('ul.menu');} if(targetMenu.length){$menu=$(targetMenu);} $menu.slideToggle();} e.stopPropagation();});$menu.off().on('click','.menu-item > a[href*="#"]:not([href="#"])',function(e){var $href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5cb735f42d5d2',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'54',mobileStacked:true,});});})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5cf92200ec99d',type:'accordion',mobile:'hamburger',mobileBelowRow:false,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'always',postId:'54',mobileStacked:true,});});})(jQuery);;jQuery(function($){$(function(){$('.fl-node-5cf92200ec9a1 .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;jQuery(function($){$(function(){$('.fl-node-8da502y39tlv .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;;(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else if(isPushMenu){activePos=activePos+headerPos;} flyoutMenu.data('activePos',activePos);if(isPushMenu){flyoutLayout='push-'+flyoutPos;} else if(isOverlay){flyoutLayout='overlay-'+flyoutPos;} if(isPushMenu&&!$('html').hasClass('fl-theme-builder-has-flyout-menu')){$('html').addClass('fl-theme-builder-has-flyout-menu');} if(!flyoutParent.hasClass('fl-theme-builder-flyout-menu-'+flyoutLayout)){flyoutParent.addClass('fl-theme-builder-flyout-menu-'+flyoutLayout);} if(!header.hasClass('fl-theme-builder-flyout-menu-overlay')&&isOverlay){header.addClass('fl-theme-builder-flyout-menu-overlay');} if(!header.hasClass('fl-theme-builder-header-full-width')&&isFullWidth){header.addClass('fl-theme-builder-header-full-width');} else if(!isFullWidth){header.removeClass('fl-theme-builder-header-full-width');} menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} if(this.hasAdminBar&&this.win.width()<=600){wpAdminBarHeight=Math.floor($('#wpadminbar').outerHeight());} totalHeaderHeight=Math.floor(beforeHeaderHeight+headerHeight);if(headerHeight>0){var headerParent=this.header.parent(),headerParentTopPadding=0;if($(headerParent).is('body')){headerParentTopPadding=Math.floor(headerHeight-wpAdminBarHeight);}else{headerParentTopPadding=Math.floor(headerHeight-bodyTopPadding-wpAdminBarHeight);} $(headerParent).css('padding-top',(headerParentTopPadding-beforeHeaderFix)+'px');this.header.css({'-webkit-transform':'translate(0px, -'+totalHeaderHeight+'px)','-ms-transform':'translate(0px, -'+totalHeaderHeight+'px)','transform':'translate(0px, 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