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class="dxeListBoxItem_MetropolisBlue">Category</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">MESH Heading</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Grant Agency</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">RCAID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">DOI</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMCID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Author</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Affiliation</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td 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class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="OpeartorItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Contains</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Equals</td> </tr> </table> </div></td> </tr> </table><script id="dxss_597138281" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_24426426" type="text/javascript">  </script><script id="dxss_1793334323" type="text/javascript">  </script> </li> <li id="TermInputContainer" class="fl TermInputContainer"> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue input-text SearchTermText dxeTextBoxDefaultWidthSys" id="SearchTerm"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="SearchTerm_I" name="ctl00$SearchTerm" onfocus="ASPx.EGotFocus('SearchTerm')" onblur="ASPx.ELostFocus('SearchTerm')" onchange="ASPx.EValueChanged('SearchTerm')" value="Immune System/metabolism" type="text" /></td> </tr> </table><script id="dxss_543298418" type="text/javascript">  </script> <span class="search-icon-container"> <a class="search-icon" href="javascript:openCategorySelector(1);"><img src="/Contents/Images/search.png" /></a> </span> </li> <li class="fl"> <div class="dxbButton_MetropolisBlue SearchButton dxbButtonSys dxbTSys" id="SearchArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="SearchArticle_I" class="dxb-hb" value="Find an Article" type="submit" name="ctl00$SearchArticle" /><span class="dx-vam">Find an Article</span> </div> </div><script id="dxss_842240986" type="text/javascript">  </script> </li> </ul> <div class="cl"></div> <div class="search-menu"> <span>Find an Article (55847579)</span>   <a href="/Categories" target="_blank">Find a Category (125)</a>   <a href="/SearchJournal" target="_blank">Find a Journal (6158)</a>   <a href="/searchscholar" target="_blank">Find a Scholar (3752)</a>   <a href="/searchacademicassistant" target="_blank">Find an Academic Assistant (18)</a> </div> <div class="search-menu" style="text-align:center;"> <span>Find an Article PDF (4650787)</span>   <a href="/TodayArticles" target="_self">Today's Articles (1264)</a>   <span>Subscriber (50912)</span> </div> </div> </div> </div> <script src="/bundles/UserAcademicAchievement?v=QYKvd9c2mOpOgKt90go7osO6NdxcNzivChzWAq_gw3g1"></script> <script type="text/javascript"> $(function () { try { var sort = getQueryString2('sort'); if (sort != null && sort != '') { if ($("[field='st" + sort + "']").length) { $("[field='st" + sort + "']").addClass("sort-highlight"); } if ($("#" + sort + "sortedCheck").length) { $("#" + sort + "sortedCheck").prop("checked", true); } } $("a.readmore").click(function () { $(this).parent().toggle().next().toggle(); }); $("a.readless").click(function () { 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LoadingPanel.Show(); var uri = "/api/BpgUser/DeleteFriend?id=" + id; $.ajax({ type: "get", url: uri, async: false }).done(function () { window.location.href = window.location.href; }); } } function SelectAllFriend() { $("input[name='checkfriend']").each(function () { $(this).attr("checked", $('#selectAllFriend').prop("checked")); }); onCheckFriendClick(); } function onCheckFriendClick() { var itemArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); }); if (itemArray.length > 0) { $("#BatchMessageContainer").show(); } else { $("#BatchMessageContainer").hide(); } } function SendBatchMessages() { var itemArray = new Array(); var idArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); idArray.push($(this).attr("data-id")); }); if (itemArray.length > 0) { if (itemArray.length == 1) { OpenMessage(idArray[0], itemArray[0]); } else { var friendIds = JSON.stringify(itemArray); OpenBatchFriendMessage(friendIds); } } } function ImportSingleArticle(doi, controlId) { if (doi != '') { LoadingPanel.Show(); var uri = "/api/BpgUser/ImportArticle?doiPmid=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function (data) { LoadingPanel.Hide(); if (data) { alert("Import Successfully!"); var currentControl = $("#" + controlId); currentControl.parent().hide(); } }).always(function () { LoadingPanel.Hide(); }); } } function ImportAllArticles() { LoadingPanel.Show(); var term = getQueryString2('term'); var uri = "/api/BpgUser/ImportArticlesFromSearch?term=" + term; $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function () { LoadingPanel.Hide(); alert("Imorting is executing!"); }).always(function () { LoadingPanel.Hide(); }); } </script> <input type="hidden" name="ctl00$RootHolder$RCAId" id="RCAId" /> <input type="hidden" name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">1357</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (304)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (882)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Immune System/metabolism</label> </div> <div id="yearFacetContainer"> <div class="mnavbar"> <div> Year Published </div> </div> <div class="mnavbox"> <div id="yearFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('year');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refineyearcheck" target="_self">Refine</a> </div> </div> </div> <div id="jsFacetContainer"> <div class="mnavbar"> <div> Article Statistics </div> </div> <div class="mnavbox"> <div id="jsFacetItemContainer"> </div> <div class="refine-btn-container cl" name="refinejscheck"> <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejscheck" target="_self">Refine</a> </div> </div> </div> <div class="mnavbar"> <div> Ranked By </div> </div> <div class="mnavbox"> <ul class="ul sortedby-list"> <li> <input type="radio" id="aisortedCheck" onclick="SetSorted('ai')" name="sortedbycheck" value="aisorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('ai')" id="aisorted">Impact Index Per Article</a> </li> <li> <input type="radio" id="citedf6sortedCheck" onclick="SetSorted('citedf6')" name="sortedbycheck" value="citedf6sorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('citedf6')" id="citedf6sorted"> Citation(s) in <i>RCA</i> </a> </li> </ul> </div> <div id="RootHolder_ResultsAnalysisContainer"> <div class="mnavbar"> <div> Results Analysis </div> </div> <div class="mnavbox"> <ul class="ul analysis-list"> <li> <input type="checkbox" id="YearAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="year" />  <label for="YearAnalysis">Year Published Analysis</label> </li> <li> <input type="checkbox" id="ArticleTypeAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="at" />  <label for="ArticleTypeAnalysis">Article Type Analysis</label> </li> <li> <input type="checkbox" id="JournalTitleAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="journal" />  <label for="JournalTitleAnalysis">Publication Title Analysis</label> </li> <li> <input type="checkbox" id="CategoriesAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="subject" />  <label for="CategoriesAnalysis">Category Analysis</label> </li> </ul> <div class="refine-btn-container cl" name="analysis-check-btn-container"> <a href="javascript:ResultAnalysis();" class="refine-link-btn refine-link-btn-right" target="_self">Results Analysis</a> </div> </div> </div> <div class="refine-btn-container-n cl" id="showFacetsContainer"> <a href="javascript:InitAllFacets();" class="refine-link-btn-right" target="_self">Show more</a> </div> <div id="facetsContainer" class="cl" style="display: none;"> <div class="mnavbar" id="PubDateFacetTitle"> <div> Indexed Articles </div> </div> <div class="mnavbox" id="PubDateFacetContainer"> <ul class="ul 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class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejournalcheck" target="_self">Refine</a> </div> </div> </div> <div id="fundFacetContainer"> <div class="mnavbar"> <div> Grant Agencies </div> </div> <div class="mnavbox"> <div id="fundFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('fund');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinefundcheck" target="_self">Refine</a> </div> </div> </div> <div id="subjectFacetContainer"> <div class="mnavbar"> <div> Category </div> </div> <div class="mnavbox"> <div id="subjectFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('subject');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Saiz-Ladera C</b>. Generation of a Mouse Model for the Study of Thyroid Hormones Regulatory Effect on the Immune System. <em class='incite-journal-name' onclick='ShowInCiteJournal(169595);'>Methods Mol Biol</em> 2025;<b>2876</b>:61-75. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39579308' target='_blank'>39579308</a> DOI: <a href='https://dx.doi.org/10.1007/978-1-0716-4252-8_4' target='_blank'>10.1007/978-1-0716-4252-8_4</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/978-1-0716-4252-8_4','39579308', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/978-1-0716-4252-8_4' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169595);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/25/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1007/978-1-0716-4252-8_4" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The generation of hypothyroid and hyperthyroid mouse models is one of the approaches used to investigate the complex interplay between thyroid hormones and the immune system. We present a detailed protocol describing how to induce endotoxic shock by lipopolysaccharide (LPS) administration, and how to investigate the role of immune populations, specifically macrophages, responding to endotoxemia.This book chapter provides the use of different molecular techniques, such as Western Blotting, Immunohistochemistry, q-PCR, Luciferase assays, or ChIP assays, with which researchers can gain valuable insights into the immune system's interaction with hormonal signaling pathways, for instance, examining the effect of thyroid hormones on signaling of STAT3, NF-κB, and ERK in response to LPS, and inflammatory mediators, such as interleukin-6 (IL-6) or tumor necrosis factor-alpha (TNFα) within these cells. The signaling pathways involved and the exploration of the relationship between thyroid hormones and the immune system can be analyzed using several molecular biology technologies in order to clarify their interplay in various disease states. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endotoxemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endotoxemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperthyroidism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperthyroidism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypothyroidism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypothyroidism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune response</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharide+(LPS)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharide (LPS)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mouse+model%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mouse model</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thyroid+hormone+receptors+(TRs)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thyroid hormone receptors (TRs)</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thyroid+Hormones%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thyroid Hormones/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factor-alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factor-alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-6%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-6/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shock%2c+Septic%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shock, Septic/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shock%2c+Septic%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shock, Septic/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shock%2c+Septic%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shock, Septic/chemically induced</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Kustrimovic N</b>, Balkhi S, Bilato G, Mortara L. Gut Microbiota and Immune System Dynamics in Parkinson's and Alzheimer's Diseases. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2024;<b>25</b>:12164. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39596232' target='_blank'>39596232</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595203' target='_blank'>PMC11595203</a> DOI: <a href='https://dx.doi.org/10.3390/ijms252212164' target='_blank'>10.3390/ijms252212164</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms252212164','39596232', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(2);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms252212164' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/28/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.3390/ijms252212164" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The gut microbiota, a diverse collection of microorganisms in the gastrointestinal tract, plays a critical role in regulating metabolic, immune, and cognitive functions. Disruptions in the composition of these microbial communities, termed dysbiosis, have been linked to various neurodegenerative diseases (NDs), such as Parkinson's disease (PD) and Alzheimer's disease (AD). One of the key pathological features of NDs is neuroinflammation, which involves the activation of microglia and peripheral immune cells. The gut microbiota modulates immune responses through the production of metabolites and interactions with immune cells, influencing the inflammatory processes within the central nervous system. This review explores the impact of gut dysbiosis on neuroinflammation, focusing on the roles of microglia, immune cells, and potential therapeutic strategies targeting the gut microbiota to alleviate neuroinflammatory processes in NDs. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer%e2%80%99s+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer’s disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Parkinson%e2%80%99s+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Parkinson’s disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microbiota%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microbiota</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurodegenerative+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurodegenerative diseases</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Parkinson+Disease%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Parkinson Disease/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Parkinson+Disease%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Parkinson Disease/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Parkinson+Disease%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Parkinson Disease/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dysbiosis%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dysbiosis/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dysbiosis%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dysbiosis/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammatory+Diseases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammatory Diseases/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammatory+Diseases%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammatory Diseases/microbiology</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fondi+di+Ateneo+per+la+Ricerca+University+of+Insubria%2c+Varese%2c+Italy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fondi di Ateneo per la Ricerca FAR2022 and FAR2023 Fondi di Ateneo per la Ricerca University of Insubria, Varese, Italy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministry+of+Health+-+IRCCS+MultiMedica%2c+Milan%2c+Italy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ricerca Corrente Ministry of Health - IRCCS MultiMedica, Milan, Italy</a></li></ul> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Passacatini LC</b>, Ilari S, Nucera S, Scarano F, Macrì R, Caminiti R, Serra M, Oppedisano F, Maiuolo J, Palma E, Malafoglia V, Tomino C, Fini M, Mollace V, Muscoli C. Multiple Aspects of Irritable Bowel Syndrome and the Role of the Immune System: An Overview of Systematic Reviews with a Focus on Polyphenols. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2024;<b>25</b>:11993. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39596064' target='_blank'>39596064</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11593788' target='_blank'>PMC11593788</a> DOI: <a href='https://dx.doi.org/10.3390/ijms252211993' target='_blank'>10.3390/ijms252211993</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms252211993','39596064', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(3);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms252211993' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/28/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.3390/ijms252211993" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Irritable bowel syndrome (IBS) is a complex and often debilitating condition that significantly impacts the gastrointestinal system and the overall quality of life of those affected. IBS is characterized by a variety of distressing symptoms, including cramping, abdominal pain, and irregular bowel movements, underlined by an intricate interplay of immune system dysfunction in its pathology. Numerous studies highlight an increased cellular immune response, with elevated levels of proinflammatory cytokines, mucosal alterations due to immune imbalance, and visceral hypersensitivity. Notably, studies indicate increased levels of proinflammatory cytokines, immune imbalances that lead to mucosal changes, and heightened visceral sensitivity. The roles of effector and regulatory T cells are particularly intriguing, as their modification appears to amplify inflammation and may even contribute to autoimmune disorders. This overview of systematic reviews explores the connections between IBS and immune responses, with a focus on immune cell alterations and proliferation of lymphocytes and mast cells in affected individuals. Furthermore, we explore various aspects of IBS management, including its pharmacological approaches. A systematic search of PubMed and Web of Science yielded 676 articles, which were ultimately narrowed down to 9 key studies that met our inclusion criteria. These studies collectively underscore the activation of the immune system with the degranulation of the mast cells in patients with IBS, where the release of inflammatory mediators can compromise intestinal permeability, exacerbating symptoms further. Additionally, we examine the multifaceted management strategies for IBS, emphasizing the potential therapeutic benefits of dietary polyphenols as antioxidants. The present study aims to enhance our understanding of IBS and offer insights into more effective treatment strategies for this challenging condition. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IBS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IBS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22polyphenols%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">polyphenols</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Irritable+Bowel+Syndrome%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Irritable Bowel Syndrome/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Irritable+Bowel+Syndrome%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Irritable Bowel Syndrome/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polyphenols%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polyphenols/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polyphenols%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polyphenols/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mast+Cells%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mast Cells/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mast+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mast Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mast+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mast Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Systematic+Reviews+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Systematic Reviews as Topic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministero+della+Salute%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SG-2021-12375551 Ministero della Salute</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministero+della+Salute%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GR-2021-12375174 Ministero della Salute</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PRIN%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">202273HF83 PRIN</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PRODIGI%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B83C22002820006 PRODIGI</a></li></ul> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Meng L</b>, Chen HM, Zhang JS, Wu YR, Xu YZ. Matricellular proteins: From cardiac homeostasis to immune regulation. <em class='incite-journal-name' onclick='ShowInCiteJournal(3668);'>Biomed Pharmacother</em> 2024;<b>180</b>:117463. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39305814' target='_blank'>39305814</a> DOI: <a href='https://dx.doi.org/10.1016/j.biopha.2024.117463' target='_blank'>10.1016/j.biopha.2024.117463</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biopha.2024.117463','39305814', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biopha.2024.117463' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3668);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/14/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.biopha.2024.117463" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Tissue repair after myocardial injury is a complex process involving changes in all aspects of the myocardial tissue, including the extracellular matrix (ECM). The ECM is composed of large structural proteins such as collagen and elastin and smaller proteins with major regulatory properties called matricellular proteins. Matricellular cell proteins exert their functions and elicit cellular responses by binding to structural proteins not limited to interactions with cell surface receptors, cytokines, or proteases. At the same time, matricellular proteins act as the "bridge" of information exchange between cells and ECM, maintaining the integrity of the cardiac structure and regulating the immune environment, which is a key factor in determining cardiac homeostasis. In this review, we present an overview of the identified matricellular proteins and summarize the current knowledge regarding their roles in maintaining cardiac homeostasis and regulating the immune system. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardiac+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardiac injury</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Matricellular+proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Matricellular proteins</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Homeostasis%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Homeostasis/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Matrix+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Matrix Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardium%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardium/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardium%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardium/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Matrix%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Matrix/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Heart%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Heart/physiology</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Borba V</b>, Carrera-Bastos P, Zandman-Goddard G, Lucia A, Shoenfeld Y. Prolactin's paradox: Friend, foe, or both in immune regulation? <em class='incite-journal-name' onclick='ShowInCiteJournal(3318);'>Autoimmun Rev</em> 2024;<b>23</b>:103643. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39306220' target='_blank'>39306220</a> DOI: <a href='https://dx.doi.org/10.1016/j.autrev.2024.103643' target='_blank'>10.1016/j.autrev.2024.103643</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.autrev.2024.103643','39306220', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.autrev.2024.103643' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3318);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.autrev.2024.103643" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Over 100 diseases have been recognized as autoimmune in nature, collectively affecting ∼20 % of the population in industrialized countries. These conditions are more prevalent among women of childbearing age, reflecting the potential association between alterations in the immune-neuroendocrine network, on the one hand, and autoimmune conditions, on the other. Prolactin (PRL), a polypeptide hormone that is primarily (but not only) secreted by the lactotrophic cells of the pituitary gland, is a critical element of the immune-neuroendocrine network. Although this hormone has several nonimmune functions, its role in regulating immune responses and affecting autoimmune inflammation is particularly enigmatic and controversial. Indeed, PRL interacts with various immune cells to bolster the body defenses, but also potentially to exacerbate autoimmune conditions. Understanding how and when PRL acts as a 'friend or foe' is crucial for unraveling its role as a potential therapeutic target in the management of autoimmune diseases (AIDs). This review therefore provides a critical overview of PRL's role in the immune system, and of the influence of this pleiotropic hormone in the development of autoimmunity. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autoimmune+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autoimmune diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hormone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hormone</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperprolactinemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperprolactinemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macroprolactin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macroprolactin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prolactin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prolactin</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prolactin%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prolactin/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prolactin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prolactin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autoimmune+Diseases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autoimmune Diseases/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autoimmunity%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autoimmunity/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunomodulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunomodulation</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Lin J</b>, Huang J, Tan C, Wu S, Lu X, Pu J. LncRNA MEG3 suppresses hepatocellular carcinoma by stimulating macrophage M1 polarization and modulating immune system via inhibiting CSF-1 in vivo/vitro studies. <em class='incite-journal-name' onclick='ShowInCiteJournal(11467);'>Int J Biol Macromol</em> 2024;<b>281</b>:136459. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39396590' target='_blank'>39396590</a> DOI: <a href='https://dx.doi.org/10.1016/j.ijbiomac.2024.136459' target='_blank'>10.1016/j.ijbiomac.2024.136459</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ijbiomac.2024.136459','39396590', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ijbiomac.2024.136459' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11467);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.ijbiomac.2024.136459" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Hepatocellular carcinoma (HCC) is characterized by a complex tumor microenvironment (TME), and long non-coding RNAs (lncRNAs) MEG3 emerged as regulators of macrophage polarization with a negative relationship with colony-stimulating factor 1 (CSF-1). Few studies are on the interplay among MEG3, CSF-1, T helper cells (Th), and the programmed cell death protein 1 and its ligands (PD-1/PD-Ls) in TME of HCC.MEG3 expression in THP-1 macrophages, monitored polarization, and PD-1/PD-Ls expression were through flow cytometry, WB, and RT-qPCR. In co-cultures, the interaction of MEG3, macrophage, and HCC was assayed by ELISA. The invasive and migratory of HCC were assessed through experiments such as CCK-8, clonogenic assay, wound healing, and Transwell. A xenograft mouse model of HCC was established, administered with MEG3 overexpression (OE) or knockdown (KD) constructs, and monitored tumor growth. In vitro, MEG3 OE induced a robust M1 macrophage phenotype, evidenced by elevated expression of M1 markers and a significant increase in Th1 cytokines, with a concomitant decrease in Th2 cytokines. This was paralleled by reduced CSF-1 and PD-1/PD-Ls expression. In contrast, MEG3 KD promoted an M2 phenotype with increased CSF-1 and PD-1/PD-Ls expression, and an upregulation of Th2 cytokines. MEG3 OE inhibited the growth, invasion, and migration of HCC, while the opposite was observed when MEG3 was downregulated. In vivo, MEG3 OE resulted in significantly reduced tumor growth, with decreased PD-1/PD-Ls expression on macrophages and enhanced Th1 response. Conversely, MEG3 KD promoted tumor growth with increased PD-1/PD-Ls and a Th2-skewed immune response. MEG3 modulates the TME by affecting TAMs through CSF-1, thereby influencing the balance of Th1/Th2 cells and altering the expression of PD-1/PD-L1s. This study demonstrates that targeting MEG3 is an effective therapeutic strategy for HCC. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colony-stimulating+factor-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colony-stimulating factor-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocellular+carcinoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocellular carcinoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Long+non-coding+RNA+MEG3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Long non-coding RNA MEG3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Programmed+cell+death+protein+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Programmed cell death protein 1</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Hepatocellular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Hepatocellular/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+Colony-Stimulating+Factor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage Colony-Stimulating Factor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+Colony-Stimulating+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage Colony-Stimulating Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Programmed+Cell+Death+1+Receptor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Programmed Cell Death 1 Receptor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Programmed+Cell+Death+1+Receptor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Programmed Cell Death 1 Receptor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Movement%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Movement/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22THP-1+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">THP-1 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B7-H1+Antigen%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B7-H1 Antigen/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B7-H1+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B7-H1 Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Iriarte-Gahete M</b>, Tarancon-Diez L, Garrido-Rodríguez V, Leal M, Pacheco YM. Absolute and functional iron deficiency: Biomarkers, impact on immune system, and therapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3763);'>Blood Rev</em> 2024;<b>68</b>:101227. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39142965' target='_blank'>39142965</a> DOI: <a href='https://dx.doi.org/10.1016/j.blre.2024.101227' target='_blank'>10.1016/j.blre.2024.101227</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.blre.2024.101227','39142965', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.blre.2024.101227' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3763);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.blre.2024.101227" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Iron is essential for numerous physiological processes and its deficiency often leads to anemia. Iron deficiency (ID) is a global problem, primarily affecting reproductive-age women and children, especially in developing countries. Diagnosis uses classical biomarkers like ferritin or transferrin saturation. Recent advancements include using soluble transferrin receptor (sTfR) or hepcidin for improved detection and classification of absolute and functional iron deficiencies, though mostly used in research. ID without anemia may present symptoms like asthenia and fatigue, even without relevant clinical consequences. ID impacts not only red-blood cells but also immune system cells, highlighting its importance in global health and immune-related comorbidities. Managing ID, requires addressing its cause and selecting appropriate iron supplementation. Various improved oral and intravenous products are available, but further research is needed to refine treatment strategies. This review updates on absolute and functional iron deficiencies, their relationships with the immune system and advancements in diagnosis and therapies. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferritin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferritin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepcidin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepcidin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Iron+deficiency%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Iron deficiency</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Soluble+transferrin+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Soluble transferrin receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anemia</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anemia%2c+Iron-Deficiency%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anemia, Iron-Deficiency/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anemia%2c+Iron-Deficiency%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anemia, Iron-Deficiency/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anemia%2c+Iron-Deficiency%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anemia, Iron-Deficiency/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anemia%2c+Iron-Deficiency%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anemia, Iron-Deficiency/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Iron+Deficiencies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Iron Deficiencies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Iron%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Iron/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Management%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Management</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Transferrin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Transferrin</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Aravind L</b>, Nicastro GG, Iyer LM, Burroughs AM. The Prokaryotic Roots of Eukaryotic Immune Systems. <em class='incite-journal-name' onclick='ShowInCiteJournal(2224);'>Annu Rev Genet</em> 2024;<b>58</b>:365-389. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39265037' target='_blank'>39265037</a> DOI: <a href='https://dx.doi.org/10.1146/annurev-genet-111523-102448' target='_blank'>10.1146/annurev-genet-111523-102448</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1146/annurev-genet-111523-102448','39265037', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1146/annurev-genet-111523-102448' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(2224);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/14/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1146/annurev-genet-111523-102448" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Over the past two decades, studies have revealed profound evolutionary connections between prokaryotic and eukaryotic immune systems, challenging the notion of their unrelatedness. Immune systems across the tree of life share an operational framework, shaping their biochemical logic and evolutionary trajectories. The diversification of immune genes in the prokaryotic superkingdoms, followed by lateral transfer to eukaryotes, was central to the emergence of innate immunity in the latter. These include protein domains related to nucleotide second messenger-dependent systems, NAD+/nucleotide degradation, and P-loop NTPase domains of the STAND and GTPase clades playing pivotal roles in eukaryotic immunity and inflammation. Moreover, several domains orchestrating programmed cell death, ultimately of prokaryotic provenance, suggest an intimate link between immunity and the emergence of multicellularity in eukaryotes such as animals. While eukaryotes directly adopted some proteins from bacterial immune systems, they repurposed others for new immune functions from bacterial interorganismal conflict systems. These emerging immune components hold substantial biotechnological potential. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caspase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">caspase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22deaminase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">deaminase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22effectors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">effectors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune signaling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nucleotides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nucleotides</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prokaryotic+Cells%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prokaryotic Cells/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prokaryotic+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prokaryotic Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eukaryota%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eukaryota/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eukaryota%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eukaryota/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteria%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteria/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteria%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteria/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Evolution%2c+Molecular%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Evolution, Molecular</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phylogeny%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phylogeny</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biological+Evolution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biological Evolution</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Hu T</b>, Liu CH, Lei M, Zeng Q, Li L, Tang H, Zhang N. Metabolic regulation of the immune system in health and diseases: mechanisms and interventions. <em class='incite-journal-name' onclick='ShowInCiteJournal(21209);'>Signal Transduct Target Ther</em> 2024;<b>9</b>:268. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39379377' target='_blank'>39379377</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461632' target='_blank'>PMC11461632</a> DOI: <a href='https://dx.doi.org/10.1038/s41392-024-01954-6' target='_blank'>10.1038/s41392-024-01954-6</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41392-024-01954-6','39379377', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(9);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41392-024-01954-6' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(21209);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/10/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1038/s41392-024-01954-6" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic regulation of the immune system is important in the pathogenesis and progression of numerous diseases, such as cancers, autoimmune diseases and metabolic diseases. The concept of immunometabolism was introduced over a decade ago to elucidate the intricate interplay between metabolism and immunity. The definition of immunometabolism has expanded from chronic low-grade inflammation in metabolic diseases to metabolic reprogramming of immune cells in various diseases. With immunometabolism being proposed and developed, the metabolic regulation of the immune system can be gradually summarized and becomes more and more clearer. In the context of many diseases including cancer, autoimmune diseases, metabolic diseases, and many other disease, metabolic reprogramming occurs in immune cells inducing proinflammatory or anti-inflammatory effects. The phenotypic and functional changes of immune cells caused by metabolic regulation further affect and development of diseases. Based on experimental results, targeting cellular metabolism of immune cells becomes a promising therapy. In this review, we focus on immune cells to introduce their metabolic pathways and metabolic reprogramming, and summarize how these metabolic pathways affect immune effects in the context of diseases. We thoroughly explore targets and treatments based on immunometabolism in existing studies. The challenges of translating experimental results into clinical applications in the field of immunometabolism are also summarized. We believe that a better understanding of immune regulation in health and diseases will improve the management of most diseases. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunological+disorders%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunological disorders</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunopathogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunopathogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22adaptive+immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">adaptive immunity</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autoimmune+Diseases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autoimmune Diseases/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autoimmune+Diseases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autoimmune Diseases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycolysis%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycolysis/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Phosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Phosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Networks+and+Pathways%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Networks and Pathways/immunology</a></li><li><a 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National Natural Science Foundation of China (National Science Foundation of China)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+National+Natural+Science+Foundation+(81970738)%2c+the+Natural+science+foundation+project+of+Sichuan+(2024NSFSC0599)%2c+the+Key+Research+and+Development+Program+of+Chengdu+(2023-YF09-00052-SN)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">the National Natural Science Foundation (81970738), the Natural science foundation project of Sichuan (2024NSFSC0599), the Key Research and Development Program of Chengdu (2023-YF09-00052-SN)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%221.3.5+project+for+disciplines+of+excellence%2c+West+China+Hospital%2c+Sichuan+University+(No.ZYGD23030)%2cthe+National+Key+Research+and+Development+Program+of+China+(No.2022YFC2304800)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (No.ZYGD23030),the National Key Research and Development Program of China (No.2022YFC2304800)</a></li></ul> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Zhang M</b>, Gou Z, Qu Y, Su X. The indispensability of methyltransferase-like 3 in the immune system: from maintaining homeostasis to driving function. <em class='incite-journal-name' onclick='ShowInCiteJournal(9345);'>Front Immunol</em> 2024;<b>15</b>:1456891. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39416774' target='_blank'>39416774</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479892' target='_blank'>PMC11479892</a> DOI: <a href='https://dx.doi.org/10.3389/fimmu.2024.1456891' target='_blank'>10.3389/fimmu.2024.1456891</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fimmu.2024.1456891','39416774', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fimmu.2024.1456891' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fimmu.2024.1456891');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9345);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/19/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.3389/fimmu.2024.1456891" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Methyltransferase-like 3(METTL3), recognized as the primary N6-methyladenosine methyltransferase, influences cellular functions such as proliferation, migration, invasion, differentiation, and fate determination by regulating gene expression post-transcriptionally. Recent studies have highlighted the indispensability of METTL3 in various immune cells such as hematopoietic stem/progenitor cells, innate immune cells (monocytes, macrophages, dendritic cells), and adaptive immune cells (thymic epithelial cell, T cells, natural killer cells). However, a comprehensive summary and analysis of these findings to elucidate the relationship between METTL3 and the immune system is yet to be undertaken. Therefore, in this review, we systematically collate reports detailing the mechanism underlying the role of METTL3 in regulating various immune processes and examine the modification of METTL3 and its potential implications. This review suggests that METTL3 plays an essential role in the immune system, ranging from maintaining homeostasis to regulating functions. Collectively, this review provides a comprehensive analysis of the relationship between METTL3 and the immune system, serving convenient researchers to understand the frontiers of immunological research and facilitate future clinical applications. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22adaptive+immune+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">adaptive immune cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hematopoietic+stem%2fprogenitor+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hematopoietic stem/progenitor cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22innate+immune+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">innate immune cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22methyltransferase-like+3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">methyltransferase-like 3</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methyltransferases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methyltransferases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methyltransferases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methyltransferases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Homeostasis%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Homeostasis/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptive+Immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptive Immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Calvo JR</b>, Maldonado MD. Immunoregulatory properties of melatonin in the humoral immune system: A narrative review. <em class='incite-journal-name' onclick='ShowInCiteJournal(10922);'>Immunol Lett</em> 2024;<b>269</b>:106901. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39032910' target='_blank'>39032910</a> DOI: <a href='https://dx.doi.org/10.1016/j.imlet.2024.106901' target='_blank'>10.1016/j.imlet.2024.106901</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.imlet.2024.106901','39032910', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.imlet.2024.106901' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10922);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/23/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.imlet.2024.106901" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Melatonin is the major product both synthesized and secreted by the pineal gland during the night period and it is the principal chronobiotic hormone that regulates the circadian rhythms and seasonal changes in vertebrate biology. Moreover, melatonin shows both a broad distribution along the phylogenetically distant organisms and a high functional versatility. At the present time, a significant amount of experimental evidence has been reported in scientific literature and has clearly shown a functional relationship between the endocrine, nervous, and immune systems. The biochemistry basis of the functional communication between these systems is the utilization of a common chemicals signals. In this framework, at present melatonin is considered to be a relevant member of the so-called neuro-endocrine-immunological network. Thus, both in vivo and in vitro investigations conducted in both experimental animals and humans, have clearly documented that melatonin has an important immunomodulatory role. However, most of the published results refer to information on T lymphocytes, i.e., cell-mediated immunity. On the contrary, fewer studies have been carried out on B lymphocytes, the cells responsible for the so-called humoral immunity. In this review, we have focused on the biological role of melatonin in the humoral immunity. More precisely, we report the actions of melatonin on B lymphocytes biology and on the production of different types of antibodies. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B+lymphocytes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B lymphocytes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humoral+immune+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humoral immune system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunoglobulins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunoglobulins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunoregulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunoregulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melatonin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melatonin</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melatonin%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melatonin/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melatonin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melatonin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Humoral%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Humoral</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B-Lymphocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B-Lymphocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunomodulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunomodulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Circadian+Rhythm%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Circadian Rhythm/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pineal+Gland%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pineal Gland/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pineal+Gland%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pineal Gland/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Comerford I</b>, McColl SR. Atypical chemokine receptors in the immune system. <em class='incite-journal-name' onclick='ShowInCiteJournal(17576);'>Nat Rev Immunol</em> 2024;<b>24</b>:753-769. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38714818' target='_blank'>38714818</a> DOI: <a href='https://dx.doi.org/10.1038/s41577-024-01025-5' target='_blank'>10.1038/s41577-024-01025-5</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41577-024-01025-5','38714818', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41577-024-01025-5' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17576);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1038/s41577-024-01025-5" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Leukocyte migration is a fundamental component of innate and adaptive immune responses as it governs the recruitment and localization of these motile cells, which is crucial for immune cell priming, effector functions, memory responses and immune regulation. This complex cellular trafficking system is controlled to a large extent via highly regulated production of secreted chemokines and the restricted expression of their membrane-tethered G-protein-coupled receptors. The activity of chemokines and their receptors is also regulated by a subfamily of molecules known as atypical chemokine receptors (ACKRs), which are chemokine receptor-like molecules that do not couple to the classical signalling pathways that promote cell migration in response to chemokine ligation. There has been a great deal of progress in understanding the biology of these receptors and their functions in the immune system in the past decade. Here, we describe the contribution of the various ACKRs to innate and adaptive immune responses, focussing specifically on recent progress. This includes recent findings that have defined the role for ACKRs in sculpting extracellular chemokine gradients, findings that broaden the spectrum of chemokine ligands recognized by these receptors, candidate new additions to ACKR family, and our increasing understanding of the role of these receptors in shaping the migration of innate and adaptive immune cells. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chemokine%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chemokine/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chemokine%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chemokine/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptive+Immunity%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptive Immunity/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemokines%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemokines/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Movement%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Movement/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukocytes/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Ghanbari M</b>, Mousavi SN, Chamani M. Effects of different lipid sources on performance, blood lipid parameters, immune system activity, and expression of TNFα and TLR4 genes in broiler chickens. <em class='incite-journal-name' onclick='ShowInCiteJournal(19837);'>Prostaglandins Other Lipid Mediat</em> 2024;<b>174</b>:106873. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39002707' target='_blank'>39002707</a> DOI: <a href='https://dx.doi.org/10.1016/j.prostaglandins.2024.106873' target='_blank'>10.1016/j.prostaglandins.2024.106873</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.prostaglandins.2024.106873','39002707', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.prostaglandins.2024.106873' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(19837);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.prostaglandins.2024.106873" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study aimed to explore the effects of different lipid sources on the performance, blood lipid parameters, immune system activity, and the expression of TNFα and TLR4 genes in broiler chickens. A total of 500 one-day-old male chicks of the ROSS 308 commercial strain were allocated into four treatment groups with five replicates each (each replicate comprised of 25 chickens), following a randomized design. The treatments were as follows: (1) a diet incorporating palm oil (PO, a source of saturated fatty acids); (2) a diet incorporating flaxseed oil (FO, a source of omega-3); (3) a diet incorporating soybean oil (SO, a source of omega-6); and (4) a diet incorporating olive oil (OO, a source of omega-9). According to the findings, the broiler chickens exhibited a significant increase in body weight gain (BWG) throughout the study when their diet consisted of unsaturated oils, as opposed to a diet including PO. Conversely, the feed conversion ratio (FCR) significantly decreased (P<0.01). The treatment with FO resulted in the highest percentage of lymphocytes and antibody titers against Newcastle and Gumboro diseases, showing a significant difference compared to the treatment with PO (P<0.01). Moreover, the relative expression of TNFα and TLR4 genes was the lowest following the FO treatment, indicating a significant decrease compared to the treatment with PO. Overall, the present findings demonstrated that incorporating omega-3 fatty acids into the diet was more effective in enhancing the growth performance, immune system, and health of broiler chickens. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Broiler%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Broiler</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+acids%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty acids</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Performance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Performance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TLR-4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TLR-4</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TNF-%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TNF-α</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chickens%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chickens/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptor+4%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptor 4/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptor+4%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptor 4/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factor-alpha%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factor-alpha/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factor-alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factor-alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipids%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipids/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animal+Feed%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animal Feed/analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Acids%2c+Omega-3%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Acids, Omega-3/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Linseed+Oil%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Linseed Oil/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Soybean+Oil%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Soybean Oil/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Palm+Oil%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Palm Oil/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Ma RX</b>. A detective story of intermittent fasting effect on immunity. <em class='incite-journal-name' onclick='ShowInCiteJournal(10918);'>Immunology</em> 2024;<b>173</b>:227-247. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38922825' target='_blank'>38922825</a> DOI: <a href='https://dx.doi.org/10.1111/imm.13829' target='_blank'>10.1111/imm.13829</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/imm.13829','38922825', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/imm.13829' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10918);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/28/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1111/imm.13829" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Intermittent fasting (IF) refers to periodic fasting routines, that caloric intake is minimized not by meal portion size reduction but by intermittently eliminating ingestion of one or several consecutive meals. IF can instigate comprehensive and multifaceted alterations in energy metabolism, these metabolic channels may aboundingly function as primordial mechanisms that interface with the immune system, instigating intricate immune transformations. This review delivers a comprehensive understanding of IF, paying particular attention to its influence on the immune system, thus seeking to bridge these two research domains. We explore how IF effects lipid metabolism, hormonal levels, circadian rhythm, autophagy, oxidative stress, gut microbiota, and intestinal barrier integrity, and conjecture about the mechanisms orchestrating the intersect between these factors and the immune system. Moreover, the review includes research findings on the implications of IF on the immune system and patients burdened with autoimmune diseases. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22intermittent+fasting%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">intermittent fasting</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fasting%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fasting</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Circadian+Rhythm%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Circadian Rhythm/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Energy+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Energy Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autoimmune+Diseases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autoimmune Diseases/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intermittent+Fasting%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intermittent Fasting</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Martins YC</b>, Rosa-Gonçalves P, Daniel-Ribeiro CT. Theories of immune recognition: Is anybody right? <em class='incite-journal-name' onclick='ShowInCiteJournal(10918);'>Immunology</em> 2024;<b>173</b>:274-285. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39034280' target='_blank'>39034280</a> DOI: <a href='https://dx.doi.org/10.1111/imm.13839' target='_blank'>10.1111/imm.13839</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/imm.13839','39034280', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(15);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/imm.13839' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10918);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/23/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1111/imm.13839" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The clonal selection theory (CST) is the centrepiece of the current paradigm used to explain immune recognition and memory. Throughout the past decades, the original CST had been expanded and modified to explain new experimental evidences since its original publication by Burnet. This gave origin to new paradigms that govern experimental immunology nowadays, such as the associative recognition of antigen model and the stranger/danger signal model. However, these new theories also do not fully explain experimental findings such as natural autoimmune immunoglobulins, idiotypic networks, low and high dose tolerance, and dual-receptor T and B cells. To make sense of these empirical data, some authors have been trying to change the paradigm of immune cognition using a systemic approach, analogies with brain processing and concepts from second-order cybernetics. In the present paper, we review the CST and some of the theories/hypotheses derived from it, focusing on immune recognition. We point out their main weaknesses and highlight arguments made by their opponents and believers. We conclude that, until now, none of the proposed theories can fully explain the totality of immune phenomena and that a theory of everything is needed in immunology. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+cognition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune cognition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neuroimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neuroimmunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neuroscience%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neuroscience</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tolerance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tolerance</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; 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text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Miyamoto Y</b>, Ishii M. Spatial heterogeneity and functional zonation of living tissues and organs in situ. <em class='incite-journal-name' onclick='ShowInCiteJournal(13179);'>J Biochem</em> 2024;<b>176</b>:271-276. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38953373' target='_blank'>38953373</a> DOI: <a href='https://dx.doi.org/10.1093/jb/mvae049' target='_blank'>10.1093/jb/mvae049</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/jb/mvae049','38953373', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(16);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1093/jb/mvae049' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13179);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/04/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1093/jb/mvae049" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">In most organs, resources such as nutrients, oxygen and physiologically active substances are unevenly supplied within the tissue spaces. Consequently, different tissue functions are exhibited in each space. This spatial heterogeneity of tissue environments arises depending on the spatial arrangement of nutrient vessels and functional vessels, leading to continuous changes in the metabolic states and functions of various cell types from regions proximal to these vessels to distant regions. This phenomenon is referred to as 'zonation'. Traditional analytical methods have made it difficult to investigate this zonation in detail. However, recent advancements in intravital imaging, spatial transcriptomics and single-cell transcriptomics technologies have facilitated the discovery of 'zones' in various organs and elucidated their physiological roles. Here, we outline the spatial differences in the immune system within each zone of organs. This information provides a deeper understanding of organs' immune systems. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22intravital+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">intravital imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22single-cell+transcriptomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">single-cell transcriptomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22spatial+transcriptomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">spatial transcriptomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22zonation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">zonation</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Single-Cell+Analysis%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Single-Cell Analysis/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Organ+Specificity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Organ Specificity</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+Program+on+the+Innovative+Development+and+the+Application+of+New+Drugs+for+Hepatitis+B%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">JP23fk0310512 the Program on the Innovative Development and the Application of New Drugs for Hepatitis B</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Japan+Agency+for+Medical+Research+and+Development+(AMED)%2c+the+Innovative+Drug+Discovery+and+Development+Project%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">JP21am0401009 Japan Agency for Medical Research and Development (AMED), the Innovative Drug Discovery and Development Project</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Japan+Society+for+the+Promotion+of+Science+(JSPS)+Grant-in-Aid+for+Scientific+Research%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">19H05657, 22 K20760, 21 J13888 Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Japan+Science+and+Technology+(JST)+Agency+CREST%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">JPMJCR15G1 Japan Science and Technology (JST) Agency CREST</a></li></ul> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Qi P</b>, Chen X, Tian J, Zhong K, Qi Z, Li M, Xie X. The gut homeostasis-immune system axis: novel insights into rheumatoid arthritis pathogenesis and treatment. <em class='incite-journal-name' onclick='ShowInCiteJournal(9345);'>Front Immunol</em> 2024;<b>15</b>:1482214. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39391302' target='_blank'>39391302</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464316' target='_blank'>PMC11464316</a> DOI: <a href='https://dx.doi.org/10.3389/fimmu.2024.1482214' target='_blank'>10.3389/fimmu.2024.1482214</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fimmu.2024.1482214','39391302', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(17);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fimmu.2024.1482214' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fimmu.2024.1482214');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9345);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/12/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.3389/fimmu.2024.1482214" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Rheumatoid arthritis is a widely prevalent autoimmune bone disease that imposes a significant burden on global healthcare systems due to its increasing incidence. In recent years, attention has focused on the interaction between gut homeostasis and the immune system, particularly in relation to bone health. Dysbiosis, which refers to an imbalance in the composition and function of the gut microbiota, has been shown to drive immune dysregulation through mechanisms such as the release of pro-inflammatory metabolites, increased gut permeability, and impaired regulatory T cell function. These factors collectively contribute to immune system imbalance, promoting the onset and progression of Rheumatoid arthritis. Dysbiosis induces both local and systemic inflammatory responses, activating key pro-inflammatory cytokines such as tumor necrosis factor-alpha, Interleukin-6, and Interleukin-17, which exacerbate joint inflammation and damage. Investigating the complex interactions between gut homeostasis and immune regulation in the context of Rheumatoid arthritis pathogenesis holds promise for identifying new therapeutic targets, revealing novel mechanisms of disease progression, and offering innovative strategies for clinical treatment. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gut+homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gut homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22novel+therapeutic+approaches%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">novel therapeutic approaches</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pathogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pathogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rheumatoid+arthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rheumatoid arthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dysbiosis%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dysbiosis/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gansu+University+of+Chinese+Medicine%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gansu University of Chinese Medicine </a></li></ul> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Wang Y</b>, Li C, Wu F, Mao J, Zhu J, Xie H, Zhou X, Wen C, Tian J. The negative effects of extracellular vesicles in the immune system. <em class='incite-journal-name' onclick='ShowInCiteJournal(9345);'>Front Immunol</em> 2024;<b>15</b>:1410273. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39372421' target='_blank'>39372421</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449741' target='_blank'>PMC11449741</a> DOI: <a href='https://dx.doi.org/10.3389/fimmu.2024.1410273' target='_blank'>10.3389/fimmu.2024.1410273</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fimmu.2024.1410273','39372421', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fimmu.2024.1410273' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fimmu.2024.1410273');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9345);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/08/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.3389/fimmu.2024.1410273" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Immunity is a critical self-defense mechanism of the human body, wherein immune cells and immune molecules play a crucial role. Extracellular vesicles (EVs), derived from immune cells or other cells, play a significant role in tumors, autoimmune diseases and other immune-related disorders by serving as carriers and facilitating intercellular communication through the transfer of cargoes. Numerous studies have revealed that EVs can exacerbate disease development by modulating immune responses. Therefore, this paper focuses on the effects of EVs on the number, activity and function of different types of immune cells and the release of immune molecules (such as cytokines, antigens, antibodies, etc) in various diseases, as well as the roles of EVs associated with different types of immune cells in various diseases. We aim to provide a comprehensive review of the negative effects that EVs play in the immune system to provide more ideas and strategies for the management of clinical immune diseases. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22extracellular+vesicles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">extracellular vesicles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22macrophage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">macrophage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22monocyte%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">monocyte</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neutrophil%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neutrophil</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Vesicles%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Vesicles/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Vesicles%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Vesicles/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Communication%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Communication/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autoimmune+Diseases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autoimmune Diseases/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Ménoret S</b>, Renart-Depontieu F, Martin G, Thiam K, Anegon I. Efficient generation of human immune system rats using human CD34<sup>+</sup> cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(21542);'>Stem Cell Reports</em> 2024;<b>19</b>:1255-1263. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39151431' target='_blank'>39151431</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411320' target='_blank'>PMC11411320</a> DOI: <a href='https://dx.doi.org/10.1016/j.stemcr.2024.07.005' target='_blank'>10.1016/j.stemcr.2024.07.005</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.stemcr.2024.07.005','39151431', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.stemcr.2024.07.005' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(21542);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/02/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/19/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1016/j.stemcr.2024.07.005" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Human immune system (HIS) mice generated using human CD34+ hematopoietic stem cells serve as a pivotal model for the in vivo evaluation of immunotherapies for humans. Yet, HIS mice possess certain limitations. Rats, due to their size and comprehensive immune system, hold promise for translational experiments. Here, we describe an efficacious method for long-term immune humanization, through intrahepatic injection of hCD34+ cells in newborn immunodeficient rats expressing human SIRPα. In contrast to HIS mice and similar to humans, HIS rats showed in blood a predominance of T cells, followed by B cells. Immune humanization was also high in central and secondary lymphoid organs. HIS rats treated with the anti-human CD3 antibody were depleted of human T cells, and human cytokines were detected in sera. We describe for the first time a method to efficiently generate HIS rats. HIS rats have the potential to be a useful model for translational immunology. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer+models%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer models</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22human+immune+system+mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">human immune system mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunodeficient+rodents%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunodeficient rodents</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22regenerative+medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">regenerative medicine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22transplantation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">transplantation</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+CD34%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, CD34/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematopoietic+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematopoietic Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematopoietic+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematopoietic Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematopoietic+Stem+Cells%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematopoietic Stem Cells/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B-Lymphocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B-Lymphocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B-Lymphocytes%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B-Lymphocytes/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematopoietic+Stem+Cell+Transplantation%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematopoietic Stem Cell Transplantation/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, Differentiation</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Elinav E</b>, Devkota S, Meisel M, Zhu S, Chu H, Chen H, Puschhof J, McAllister F, Platt RJ, Honda K. Microbes and metabolites in immunity. <em class='incite-journal-name' onclick='ShowInCiteJournal(10909);'>Immunity</em> 2024;<b>57</b>:1995-1999. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39260349' target='_blank'>39260349</a> DOI: <a href='https://dx.doi.org/10.1016/j.immuni.2024.08.011' target='_blank'>10.1016/j.immuni.2024.08.011</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.immuni.2024.08.011','39260349', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.immuni.2024.08.011' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10909);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/13/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.immuni.2024.08.011" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The immune system has a vital, albeit complex, relationship with the microbes residing within us, one that we are only beginning to understand. We asked investigators what they felt were the fundamental challenges we currently face in unraveling the impacts of microbes and their metabolites on host immunity and to discuss key opportunities toward achieving future insights and innovation. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteria%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteria/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Host-Pathogen+Interactions%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Host-Pathogen Interactions/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microbiota%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microbiota/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Jasim SA</b>, Farhan SH, Ahmad I, Hjazi A, Kumar A, Jawad MA, Pramanik A, Altalbawy FMA, Alsaadi SB, Abosaoda MK. Role of homeobox genes in cancer: immune system interactions, long non-coding RNAs, and tumor progression. <em class='incite-journal-name' onclick='ShowInCiteJournal(17395);'>Mol Biol Rep</em> 2024;<b>51</b>:964. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39240390' target='_blank'>39240390</a> DOI: <a href='https://dx.doi.org/10.1007/s11033-024-09857-z' target='_blank'>10.1007/s11033-024-09857-z</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s11033-024-09857-z','39240390', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(21);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s11033-024-09857-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17395);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/07/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1007/s11033-024-09857-z" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The intricate interplay between Homeobox genes, long non-coding RNAs (lncRNAs), and the development of malignancies represents a rapidly expanding area of research. Specific discernible lncRNAs have been discovered to adeptly regulate HOX gene expression in the context of cancer, providing fresh insights into the molecular mechanisms that govern cancer development and progression. An in-depth comprehension of these intricate associations may pave the way for innovative therapeutic strategies in cancer treatment. The HOX gene family is garnering increasing attention due to its involvement in immune system regulation, interaction with long non-coding RNAs, and tumor progression. Although initially recognized for its crucial role in embryonic development, this comprehensive exploration of the world of HOX genes contributes to our understanding of their diverse functions, potentially leading to immunology, developmental biology, and cancer research discoveries. Thus, the primary objective of this review is to delve into these aspects of HOX gene biology in greater detail, shedding light on their complex functions and potential therapeutic applications. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hox+gene+family%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hox gene family</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor progression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lncRNAs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lncRNAs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ncRNAs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ncRNAs</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genes%2c+Homeobox%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genes, Homeobox/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Progression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Deanship+of+Scientific+Research%2c+King+Khalid+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R.G.P.1/323/44 Deanship of Scientific Research, King Khalid University</a></li></ul> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Cerilli E</b>, Dall'O GM, Chelini G, Catena B, Weinberger B, Bozzi Y, Pangrazzi L. Immune system dysfunction and inflammation in aging <i>Shank3b</i> mutant mice, a model of autism spectrum disorder. <em class='incite-journal-name' onclick='ShowInCiteJournal(9345);'>Front Immunol</em> 2024;<b>15</b>:1447385. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39308859' target='_blank'>39308859</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412883' target='_blank'>PMC11412883</a> DOI: <a href='https://dx.doi.org/10.3389/fimmu.2024.1447385' target='_blank'>10.3389/fimmu.2024.1447385</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fimmu.2024.1447385','39308859', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fimmu.2024.1447385' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fimmu.2024.1447385');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9345);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/25/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.3389/fimmu.2024.1447385" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Introduction</div><div class="abstract-content">Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental Q8 conditions characterized by deficits in social interaction/communication and restrictive/repetitive behaviors. Recent studies highlight the role of immune system dysfunction and inflammation in ASD pathophysiology. Indeed, elevated levels of pro-inflammatory cytokines were described in the brain and peripheral blood of ASD individuals. Despite this, how this pro-inflammatory profile evolves with aging and whether it may be associated with behavioral deficits is unknown. In this work, we explored the impact of aging on motor behavior and inflammation using Shank3b mutant mice, a model for syndromic ASD. </div><div class="abstract-label">Methods</div><div class="abstract-content">Using RT-qPCR and flow cytometry, we examined the expression of key pro-inflammatory molecules in the cerebellum, bone marrow, spleen, and peripheral blood, comparing adult and old Shank3b +/+, Shank3b +/-, and Shank3b -/- mice. </div><div class="abstract-label">Results and discussion</div><div class="abstract-content">Our findings revealed genotype- and age-related differences in inflammation and motor behavior, with Shank3b-/- mice exhibiting accelerated aging and motor impairments. Correlations between pro-inflammatory molecules and behavioral deficits suggest that a link may be present between systemic inflammation and ASD-related behaviors, underscoring the potential role of age-related inflammation ("inflammaging") in exacerbating ASD symptoms. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+marrow%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone marrow</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22brain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">brain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cerebellum%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cerebellum</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurodevelopmental+disorder%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurodevelopmental disorder</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22spleen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">spleen</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autism+Spectrum+Disorder%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autism Spectrum Disorder/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autism+Spectrum+Disorder%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autism Spectrum Disorder/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nerve+Tissue+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nerve Tissue Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microfilament+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microfilament Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Behavior%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Behavior, Animal</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Dąbrowska A</b>, Wilczyński B, Mastalerz J, Kucharczyk J, Kulbacka J, Szewczyk A, Rembiałkowska N. The Impact of Liver Failure on the Immune System. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2024;<b>25</b>:9522. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39273468' target='_blank'>39273468</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11395474' target='_blank'>PMC11395474</a> DOI: <a href='https://dx.doi.org/10.3390/ijms25179522' target='_blank'>10.3390/ijms25179522</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms25179522','39273468', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(23);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms25179522' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/15/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.3390/ijms25179522" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Liver failure profoundly affects the immune system, leading to dysregulation of innate and adaptive immune response. This review explores the intricate relationship between liver function and immune homeostasis. The role of the liver as a central hub in immune response initiation is elucidated, emphasizing its involvement in hepatic inflammation induction and subsequent systemic inflammation. Cytokines, chemokines, growth factors, and lipid mediators orchestrate these immune processes, serving as both prognostic biomarkers and potential therapeutic targets in liver failure-associated immune dysregulation, which might result from acute-on-chronic liver failure (ACLF) and cirrhosis. Furthermore, the review delves into the mechanisms underlying immunosuppression in liver failure, encompassing alterations in innate immune cell functions such as neutrophils, macrophages, and natural killer cells (NK cells), as well as perturbations in adaptive immune responses mediated by B and T cells. Conclusion: Understanding the immunological consequences of liver failure is crucial for developing targeted therapeutic interventions and improving patient outcomes in liver disease management. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chemokines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chemokines</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chronic+liver+failure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chronic liver failure</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cytokines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cytokines</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune response</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunosuppression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunosuppression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22innate+and+adaptive+immune+response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">innate and adaptive immune response</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22liver+cirrhosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">liver cirrhosis</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Failure%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Failure/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptive+Immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptive Immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Killer+Cells%2c+Natural%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Killer Cells, Natural/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22wroclaw+medical+university%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SKN No. 148 wroclaw medical university</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22wroclaw+medical+university%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SUBZ.D260.24.076 wroclaw medical university</a></li></ul> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Wensveen FM</b>, Šestan M, Polić B. The immunology of sickness metabolism. <em class='incite-journal-name' onclick='ShowInCiteJournal(4810);'>Cell Mol Immunol</em> 2024;<b>21</b>:1051-1065. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39107476' target='_blank'>39107476</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364700' target='_blank'>PMC11364700</a> DOI: <a href='https://dx.doi.org/10.1038/s41423-024-01192-4' target='_blank'>10.1038/s41423-024-01192-4</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1038%2fs41423-024-01192-4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1038%2fs41423-024-01192-4')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41423-024-01192-4','39107476', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41423-024-01192-4' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4810);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/01/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1038/s41423-024-01192-4" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Everyone knows that an infection can make you feel sick. Although we perceive infection-induced changes in metabolism as a pathology, they are a part of a carefully regulated process that depends on tissue-specific interactions between the immune system and organs involved in the regulation of systemic homeostasis. Immune-mediated changes in homeostatic parameters lead to altered production and uptake of nutrients in circulation, which modifies the metabolic rate of key organs. This is what we experience as being sick. The purpose of sickness metabolism is to generate a metabolic environment in which the body is optimally able to fight infection while denying vital nutrients for the replication of pathogens. Sickness metabolism depends on tissue-specific immune cells, which mediate responses tailored to the nature and magnitude of the threat. As an infection increases in severity, so do the number and type of immune cells involved and the level to which organs are affected, which dictates the degree to which we feel sick. Interestingly, many alterations associated with metabolic disease appear to overlap with immune-mediated changes observed following infection. Targeting processes involving tissue-specific interactions between activated immune cells and metabolic organs therefore holds great potential for treating both people with severe infection and those with metabolic disease. In this review, we will discuss how the immune system communicates in situ with organs involved in the regulation of homeostasis and how this communication is impacted by infection. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunometabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunometabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22infection%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">infection</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammasome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metabolic+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metabolic disease</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infections%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infections/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hrvatska+Zaklada+za+Znanost+(Croatian+Science+Foundation)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IP-2020-02-7928 Hrvatska Zaklada za Znanost (Croatian Science Foundation)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hrvatska+Zaklada+za+Znanost+(Croatian+Science+Foundation)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IP-2022-10-3414 Hrvatska Zaklada za Znanost (Croatian Science Foundation)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hrvatska+Zaklada+za+Znanost+(Croatian+Science+Foundation)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IPCH-2020-10-8440 Hrvatska Zaklada za Znanost (Croatian Science Foundation)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22EC+%7c+European+Regional+Development+Fund+(Europski+Fond+za+Regionalni+Razvoj)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">KK.01.1.1.01.0006 EC | European Regional Development Fund (Europski Fond za Regionalni Razvoj)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22University+of+Rijeka+grant+18-152-1301%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">University of Rijeka grant 18-152-1301</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22University+of+Rijeka+grant+uniri-mladi-biomed-20-3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">University of Rijeka grant uniri-mladi-biomed-20-3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22University+of+Rijeka+grant+18-89-1224%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">University of Rijeka grant 18-89-1224</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Lakshmikanth T</b>, Consiglio C, Sardh F, Forlin R, Wang J, Tan Z, Barcenilla H, Rodriguez L, Sugrue J, Noori P, Ivanchenko M, Piñero Páez L, Gonzalez L, Habimana Mugabo C, Johnsson A, Ryberg H, Hallgren Å, Pou C, Chen Y, Mikeš J, James A, Dahlqvist P, Wahlberg J, Hagelin A, Holmberg M, Degerblad M, Isaksson M, Duffy D, Kämpe O, Landegren N, Brodin P. Immune system adaptation during gender-affirming testosterone treatment. <em class='incite-journal-name' onclick='ShowInCiteJournal(17166);'>Nature</em> 2024;<b>633</b>:155-164. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39232147' target='_blank'>39232147</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374716' target='_blank'>PMC11374716</a> DOI: <a href='https://dx.doi.org/10.1038/s41586-024-07789-z' target='_blank'>10.1038/s41586-024-07789-z</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1038%2fs41586-024-07789-z%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1038%2fs41586-024-07789-z')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41586-024-07789-z','39232147', 'Immune System/metabolism')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41586-024-07789-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17166);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/06/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1038/s41586-024-07789-z" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Infectious, inflammatory and autoimmune conditions present differently in males and females. SARS-CoV-2 infection in naive males is associated with increased risk of death, whereas females are at increased risk of long COVID1, similar to observations in other infections2. Females respond more strongly to vaccines, and adverse reactions are more frequent3, like most autoimmune diseases4. Immunological sex differences stem from genetic, hormonal and behavioural factors5 but their relative importance is only partially understood6-8. In individuals assigned female sex at birth and undergoing gender-affirming testosterone therapy (trans men), hormone concentrations change markedly but the immunological consequences are poorly understood. Here we performed longitudinal systems-level analyses in 23 trans men and found that testosterone modulates a cross-regulated axis between type-I interferon and tumour necrosis factor. This is mediated by functional attenuation of type-I interferon responses in both plasmacytoid dendritic cells and monocytes. Conversely, testosterone potentiates monocyte responses leading to increased tumour necrosis factor, interleukin-6 and interleukin-15 production and downstream activation of nuclear factor kappa B-regulated genes and potentiation of interferon-γ responses, primarily in natural killer cells. These findings in trans men are corroborated by sex-divergent responses in public datasets and illustrate the dynamic regulation of human immunity by sex hormones, with implications for the health of individuals undergoing hormone therapy and our understanding of sex-divergent immune responses in cisgender individuals. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22translational+research%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">translational research</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Datasets+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Datasets as Topic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dendritic+Cells%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dendritic Cells/immunology</a></li><li><a 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class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Immune System/metabolism (1357 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Immune System/metabolism (1357 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>