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<div > <div class="sf-Long-text" ><h1 class="page-title">Congratulations to the PEGS Boston Summit Poster Winners</h1><p class="Date">2024</p><div class="row"><div class="col-md-6"><p><img class="imageResize" src="/images/librariesprovider30/agenda/24/pegs-24-rc-393.jpg?sfvrsn=81e796a4_1" alt="Shelby Knoche" /></p></div><div class="col-md-6"><p><b>Shelby Knoche, SRI International</b></p><p><b>Utilizing a Cancer-Specific Peptide to Deliver a Novel Immunotherapy for the Treatment of Cancer <br /></b>TALL is a targeted nanomedicine-based cellular immunotherapy for delivering a synthetic immunogenic peptide derived from the measles virus to specifically target cancer cells and facilitate antigen presentation through the MHC class I pathway. TALL’s targeted delivery system utilizes peptidic molecular guidance systems (MGSs) that bind and internalize into cancer cells. TALL helps to recruit T cells into tumors and synergizes with immune checkpoint inhibitors, reducing tumor growth.</p></div><br clear="all" /><br clear="all" /></div><div class="row"><div class="col-md-6"><p><img class="imageResize" src="/images/librariesprovider30/agenda/24/pegs-24b-rc-120.jpg?sfvrsn=46849de1_1" alt="Alexander Partin" /></p></div><div class="col-md-6"><p><b>Alexander Partin, A2 Biotherapeutics, Inc. </b></p><p><b>Defining the Biophysical Design Parameters for Logic-Gated CAR-T Systems<br /></b>Logic-gated CAR-T systems are a promising strategy to enforce tumor selectivity, but pose new considerations for receptor design. To inform design goals for expanding the Tmod system, which employs a protective NOT gate, we characterized how antigen geometry and affinity influence inhibitory function. We define the optimal parameters for target antigens and show that a broad range of antigens can be effectively targeted using engineered hinges that enforce ideal geometry.</p></div><br clear="all" /><br clear="all" /></div></div> </div> <div > <div class="sf-Long-text" ><p class="Date">2023</p><div class="row"><div class="col-md-6"><p><img src="/images/librariesprovider30/media/23/img_999999.jpg?sfvrsn=30c68894_1" alt="Héctor Sánchez-Morán" class="imageResize" /></p></div><div class="col-md-6"><p><b>Héctor Sánchez-Morán from the University of Colorado, Boulder</b></p><p><b>Single Molecule FRET Reveals Protein Dual Stabilization Mechanism in an Immobilization Support<br /></b>Immobilization matrices for biosensor applications may promote protein unfolding via unknown mechanisms. We designed polymeric supports with novel monomers to immobilize enzymes, and we found that these supports dramatically improved protein stability in denaturing conditions. 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