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Astroglia play an important role in the initiation and propagation of hypoxia/ischemia-induced inflammation by secreting inflammatory" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/53170193/Hypoxia_inducible_factor_1_HIF_1_is_involved_in_the_regulation_of_hypoxia_stimulated_expression_of_monocyte_chemoattractant_protein_1_MCP_1_CCL2_and_MCP_5_Ccl12_in_astrocytes" /> <meta property="og:title" content="Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Background Neuroinflammation has been implicated in various brain pathologies characterized by hypoxia and ischemia. Astroglia play an important role in the initiation and propagation of hypoxia/ischemia-induced inflammation by secreting inflammatory" /> <meta property="article:author" content="https://independent.academia.edu/danicastanimirovic" /> <meta name="description" content="Background Neuroinflammation has been implicated in various brain pathologies characterized by hypoxia and ischemia. Astroglia play an important role in the initiation and propagation of hypoxia/ischemia-induced inflammation by secreting inflammatory" /> <title>(PDF) Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes | danica stanimirovic - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/53170193/Hypoxia_inducible_factor_1_HIF_1_is_involved_in_the_regulation_of_hypoxia_stimulated_expression_of_monocyte_chemoattractant_protein_1_MCP_1_CCL2_and_MCP_5_Ccl12_in_astrocytes" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = 'fdfcd03ea2af2a60c31d1f7e544fe08547bcb5a1'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732727034000); window.Aedu.timeDifference = new Date().getTime() - 1732727034000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Background Neuroinflammation has been implicated in various brain pathologies characterized by hypoxia and ischemia. Astroglia play an important role in the initiation and propagation of hypoxia/ischemia-induced inflammation by secreting inflammatory chemokines that attract neutrophils and monocytes into the brain. However, triggers of chemokine up-regulation by hypoxia/ischemia in these cells are poorly understood. Hypoxia-inducible factor-1 (HIF-1) is a dimeric transcriptional factor consisting of HIF-1α and HIF-1β subunits. HIF-1 binds to HIF-1-binding sites in the target genes and activates their transcription. We have recently shown that hypoxia-induced expression of IL-1β in astrocytes is mediated by HIF-1α. In this study, we demonstrate the role of HIF-1α in hypoxia-induced up-regulation of inflammatory chemokines, human monocyte chemoattractant protein-1 (MCP-1/CCL2) and mouse MCP-5 (Ccl12), in human and mouse astrocytes, respectively. Methods Primary fetal human astrocytes ...","author":[{"@context":"https://schema.org","@type":"Person","name":"danica stanimirovic"}],"contributor":[],"dateCreated":"2021-09-21","dateModified":"2021-09-21","datePublished":"2007-01-01","headline":"Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes","inLanguage":"en","keywords":["Immunology","Humans","Mice","Animals","Neuroinflammation","Astrocyte","Astrocytes","Transcription Factor","Clinical Sciences","Western blot","Neurosciences","Binding Site","Gene Expression Regulation","DNA sequence","Hypoxia inducible factor","binding sites","quantitative RT-PCR"],"locationCreated":null,"publication":"Journal of Neuroinflammation","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Springer Nature"},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/53170193/Hypoxia_inducible_factor_1_HIF_1_is_involved_in_the_regulation_of_hypoxia_stimulated_expression_of_monocyte_chemoattractant_protein_1_MCP_1_CCL2_and_MCP_5_Ccl12_in_astrocytes","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-102fa537001ba4d8dcd921ad9bd56c474abc201906ea4843e7e7efe9dfbf561d.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" 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Astroglia play an important role in the initiation and propagation of hypoxia/ischemia-induced inflammation by secreting inflammatory chemokines that attract neutrophils and monocytes into the brain. However, triggers of chemokine up-regulation by hypoxia/ischemia in these cells are poorly understood. Hypoxia-inducible factor-1 (HIF-1) is a dimeric transcriptional factor consisting of HIF-1α and HIF-1β subunits. HIF-1 binds to HIF-1-binding sites in the target genes and activates their transcription. We have recently shown that hypoxia-induced expression of IL-1β in astrocytes is mediated by HIF-1α. In this study, we demonstrate the role of HIF-1α in hypoxia-induced up-regulation of inflammatory chemokines, human monocyte chemoattractant protein-1 (MCP-1/CCL2) and mouse MCP-5 (Ccl12), in human and mouse astrocytes, respectively. Methods Primary fetal human astrocytes ...","publisher":"Springer Nature","publication_date":"2007,,","publication_name":"Journal of Neuroinflammation"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [76232251]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":70083411,"attachmentType":"pdf"}"><img alt="First page of “Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/70083411/mini_magick20210921-28454-w2yfmp.png?1632269781" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="76232251" href="https://independent.academia.edu/danicastanimirovic"><img alt="Profile image of danica stanimirovic" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />danica stanimirovic</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2007, Journal of Neuroinflammation</p></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Background Neuroinflammation has been implicated in various brain pathologies characterized by hypoxia and ischemia. Astroglia play an important role in the initiation and propagation of hypoxia/ischemia-induced inflammation by secreting inflammatory chemokines that attract neutrophils and monocytes into the brain. However, triggers of chemokine up-regulation by hypoxia/ischemia in these cells are poorly understood. Hypoxia-inducible factor-1 (HIF-1) is a dimeric transcriptional factor consisting of HIF-1α and HIF-1β subunits. HIF-1 binds to HIF-1-binding sites in the target genes and activates their transcription. We have recently shown that hypoxia-induced expression of IL-1β in astrocytes is mediated by HIF-1α. In this study, we demonstrate the role of HIF-1α in hypoxia-induced up-regulation of inflammatory chemokines, human monocyte chemoattractant protein-1 (MCP-1/CCL2) and mouse MCP-5 (Ccl12), in human and mouse astrocytes, respectively. Methods Primary fetal human astrocytes ...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":70083411,"attachmentType":"pdf","workUrl":"https://www.academia.edu/53170193/Hypoxia_inducible_factor_1_HIF_1_is_involved_in_the_regulation_of_hypoxia_stimulated_expression_of_monocyte_chemoattractant_protein_1_MCP_1_CCL2_and_MCP_5_Ccl12_in_astrocytes"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":70083411,"attachmentType":"pdf","workUrl":"https://www.academia.edu/53170193/Hypoxia_inducible_factor_1_HIF_1_is_involved_in_the_regulation_of_hypoxia_stimulated_expression_of_monocyte_chemoattractant_protein_1_MCP_1_CCL2_and_MCP_5_Ccl12_in_astrocytes"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="70083411" data-landing_url="https://www.academia.edu/53170193/Hypoxia_inducible_factor_1_HIF_1_is_involved_in_the_regulation_of_hypoxia_stimulated_expression_of_monocyte_chemoattractant_protein_1_MCP_1_CCL2_and_MCP_5_Ccl12_in_astrocytes" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="53170293" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/53170293/Transcriptional_activation_of_interleukin_1beta_1L_1Beta_byt_he_hypoxia_inducible_factor_1_HIF_1_in_astrocytes">Transcriptional activation of interleukin-1beta (1L-1Beta) byt he hypoxia-inducible factor-1 (HIF-1) in astrocytes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="76232251" href="https://independent.academia.edu/danicastanimirovic">danica stanimirovic</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Transcriptional activation of interleukin-1beta (1L-1Beta) byt he hypoxia-inducible factor-1 (HIF-1) in astrocytes","attachmentId":70083459,"attachmentType":"pdf","work_url":"https://www.academia.edu/53170293/Transcriptional_activation_of_interleukin_1beta_1L_1Beta_byt_he_hypoxia_inducible_factor_1_HIF_1_in_astrocytes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/53170293/Transcriptional_activation_of_interleukin_1beta_1L_1Beta_byt_he_hypoxia_inducible_factor_1_HIF_1_in_astrocytes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="101081599" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/101081599/Hypoxia_Inducible_Factor_1%CE%B1_Attenuates_Ischemic_Brain_Damage_by_Modulating_Inflammatory_Response_and_Glial_Activity">Hypoxia Inducible Factor-1α Attenuates Ischemic Brain Damage by Modulating Inflammatory Response and Glial Activity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="267931331" href="https://independent.academia.edu/MarongFang">Marong Fang</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cells, 2021</p><p class="ds-related-work--abstract ds2-5-body-sm">Hypoxia-inducible factor 1 can sufficiently control the progress of neurological symptoms after ischemic stroke owing to their actions associated with its downstream genes. In this study, we evaluated the role of HIF-1α in attenuating brain damage after endothelin-1 injection. Focal cerebral ischemia in mice were induced by endothelin-1 microinjection. Hypoxia-inducible factor 1 activator, dimethyloxalylglycine (DMOG), and HIF-1α inhibitor, acriflavine (ACF), were used to evaluate the hypoxia-inducible factor 1 activity during cerebral ischemia. The expression levels of HIF-1α, glial fibrillary acidic protein (GFAP), interleukin-10 (IL-10), inducible nitric oxide synthase (iNOS), phosphorylated I-kappa-B-alpha/total I-kappa-B-alpha (p-IκBα/IκBα) and nuclear factor kappa B (NF-kB) were assessed. Besides, mRNA levels of IL-10, tumor necrosis factor- alpha (TNF-α), and NF-kB were also analyzed. Results showed a noticeable increase in hypoxia-inducible factor 1 and IL-10 levels in the D...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hypoxia Inducible Factor-1α Attenuates Ischemic Brain Damage by Modulating Inflammatory Response and Glial Activity","attachmentId":101719430,"attachmentType":"pdf","work_url":"https://www.academia.edu/101081599/Hypoxia_Inducible_Factor_1%CE%B1_Attenuates_Ischemic_Brain_Damage_by_Modulating_Inflammatory_Response_and_Glial_Activity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/101081599/Hypoxia_Inducible_Factor_1%CE%B1_Attenuates_Ischemic_Brain_Damage_by_Modulating_Inflammatory_Response_and_Glial_Activity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="77341138" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/77341138/The_Good_the_Bad_and_the_Cell_Type_Specific_Roles_of_Hypoxia_Inducible_Factor_1_in_Neurons_and_Astrocytes">The Good, the Bad, and the Cell Type-Specific Roles of Hypoxia Inducible Factor-1 in Neurons and Astrocytes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32023921" href="https://independent.academia.edu/HowardFederoff">Howard Federoff</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Neuroscience, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Good, the Bad, and the Cell Type-Specific Roles of Hypoxia Inducible Factor-1 in Neurons and Astrocytes","attachmentId":84742112,"attachmentType":"pdf","work_url":"https://www.academia.edu/77341138/The_Good_the_Bad_and_the_Cell_Type_Specific_Roles_of_Hypoxia_Inducible_Factor_1_in_Neurons_and_Astrocytes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/77341138/The_Good_the_Bad_and_the_Cell_Type_Specific_Roles_of_Hypoxia_Inducible_Factor_1_in_Neurons_and_Astrocytes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="13495083" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13495083/The_role_and_regulation_of_hypoxia_inducible_factor_1%CE%B1_expression_in_brain_development_and_neonatal_hypoxic_ischemic_brain_injury">The role and regulation of hypoxia-inducible factor-1α expression in brain development and neonatal hypoxic–ischemic brain injury</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32700579" href="https://umcutrecht.academia.edu/FlorisGroenendaal">Floris Groenendaal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain Research Reviews, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The role and regulation of hypoxia-inducible factor-1α expression in brain development and neonatal hypoxic–ischemic brain injury","attachmentId":45271038,"attachmentType":"pdf","work_url":"https://www.academia.edu/13495083/The_role_and_regulation_of_hypoxia_inducible_factor_1%CE%B1_expression_in_brain_development_and_neonatal_hypoxic_ischemic_brain_injury","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13495083/The_role_and_regulation_of_hypoxia_inducible_factor_1%CE%B1_expression_in_brain_development_and_neonatal_hypoxic_ischemic_brain_injury"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="68118693" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/68118693/Evaluation_of_hypoxia_inducible_factor_expression_in_inflammatory_and_neurodegenerative_brain_models">Evaluation of hypoxia inducible factor expression in inflammatory and neurodegenerative brain models</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42152033" href="https://independent.academia.edu/CBeaszarate">Carlos Beaszarate</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evaluation of hypoxia inducible factor expression in inflammatory and neurodegenerative brain models","attachmentId":78709178,"attachmentType":"pdf","work_url":"https://www.academia.edu/68118693/Evaluation_of_hypoxia_inducible_factor_expression_in_inflammatory_and_neurodegenerative_brain_models","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/68118693/Evaluation_of_hypoxia_inducible_factor_expression_in_inflammatory_and_neurodegenerative_brain_models"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="81691697" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/81691697/Hypoxia_independent_mechanisms_of_HIF_1%CE%B1_expression_in_astrocytes_after_ischemic_preconditioning">Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32797713" href="https://independent.academia.edu/SchuichiKoizumi">Schuichi Koizumi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Glia, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">We recently demonstrated that ischemic tolerance was dependent on astrocytes, for which HIF-1α had an essential role. The mild ischemia (preconditioning; PC) increased HIF-1α in a biphasic pattern, that is, a quick and transient increase in neurons, followed by a slow and sustained increase in astrocytes. However, mechanisms underlying such temporal difference in HIF-1α increase remain totally unknown. Here, we show that unlike a hypoxia-dependent mechanism in neurons, astrocytes increase HIF-1α via a novel hypoxia-independent but P2X7-dependent mechanism. Using a middle cerebral artery occlusion (MCAO) model of mice, we found that the PC (a 15-min MCAO period)-evoked increase in HIF-1α in neurons was quick and transient (from 1 to 3 days after PC), but that in astrocytes was slow-onset and long-lasting (from 3 days to at least 2 weeks after PC). The neuronal HIF-1α increase was dependent on inhibition of PHD2, an oxygen-dependent HIF-1α degrading enzyme, whereas astrocytic one was ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning","attachmentId":87648484,"attachmentType":"pdf","work_url":"https://www.academia.edu/81691697/Hypoxia_independent_mechanisms_of_HIF_1%CE%B1_expression_in_astrocytes_after_ischemic_preconditioning","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/81691697/Hypoxia_independent_mechanisms_of_HIF_1%CE%B1_expression_in_astrocytes_after_ischemic_preconditioning"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="95730430" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/95730430/HIF_1%CE%B1_Deficient_Mice_Have_Increased_Brain_Injury_after_Neonatal_Hypoxia_Ischemia">HIF-1α-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32903116" href="https://independent.academia.edu/DonnaFerriero">Donna Ferriero</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Developmental Neuroscience, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">Evidence suggests that the activation of the transcription factor hypoxia-inducible factor 1α (HIF-1α) may promote cell survival in hypoxic or ischemic brain. To help understand the role of HIF-1α in neonatal hypoxic-ischemic brain injury, mice with conditional neuron-specific inactivation of HIF-1α underwent hypoxia-ischemia (HI). Mice heterozygous for Cre recombinase under the control of the calcium/calmodulin-dependent kinase II promoter were bred with homozygous ‘floxed’ HIF-1α transgenic mice. The resulting litters produced mice with a forebrain predominant neuronal deletion of HIF-1α (HIF-1αΔ/Δ), as well as littermates without the deletion. In order to verify reduction of HIF-1α at postnatal day 7, HIF-1αΔ/Δ and wild-type mice were exposed to a hypoxic stimulus (8% oxygen) or room air for 1 h, followed by immediate collection of brain cortices for determination of HIF-1α expression. Results of Western blotting of mouse cortices exposed to hypoxia stimulus or room air confirmed...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"HIF-1α-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia","attachmentId":97831555,"attachmentType":"pdf","work_url":"https://www.academia.edu/95730430/HIF_1%CE%B1_Deficient_Mice_Have_Increased_Brain_Injury_after_Neonatal_Hypoxia_Ischemia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/95730430/HIF_1%CE%B1_Deficient_Mice_Have_Increased_Brain_Injury_after_Neonatal_Hypoxia_Ischemia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="53170181" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/53170181/Inflammatory_Activation_of_Human_Brain_Endothelial_Cells_by_Hypoxic_Astrocytes_In_Vitro_Is_Mediated_by_IL_1_">Inflammatory Activation of Human Brain Endothelial Cells by Hypoxic Astrocytes In Vitro Is Mediated by IL-1??</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="76232251" href="https://independent.academia.edu/danicastanimirovic">danica stanimirovic</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Cerebral Blood Flow and Metabolism, 2000</p><p class="ds-related-work--abstract ds2-5-body-sm">Leukocyte infiltration into the brain contributes to the development of ischemic brain damage and is mediated by endothelial/leukocyte adhesion molecules, cytokines, and chemokines released by ischemic brain cells. In this study, we provide evidence that human astrocytes (FHAs) subjected to in vitro hypoxia produce proinflammatory mediator(s) capable of up-regulating inflammatory genes, including intercellular adhesion molecule-1, interleukin (IL)-1β, tumor necrosis factor-α, IL-8, and monocyte chemotactic protein-1 (MCP-1) in human cerebromicrovascular endothelial cells (HCECs). FHAS were exposed to hypoxia in an anaerobic chamber for 4 hours, followed by reoxygenation for 24 hours. Astrocyte-conditioned media (ACM) collected from normoxic FHAS or FHAS subjected to hypoxia/reoxygenation were applied to HCEC cultures for 4 to 24 hours. Semiquantitative reverse transcription–polymerase chain reaction, immunocytochemistry, and enzyme-linked immunosorbent assay demonstrated up-regulati...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Inflammatory Activation of Human Brain Endothelial Cells by Hypoxic Astrocytes In Vitro Is Mediated by IL-1??","attachmentId":70083537,"attachmentType":"pdf","work_url":"https://www.academia.edu/53170181/Inflammatory_Activation_of_Human_Brain_Endothelial_Cells_by_Hypoxic_Astrocytes_In_Vitro_Is_Mediated_by_IL_1_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/53170181/Inflammatory_Activation_of_Human_Brain_Endothelial_Cells_by_Hypoxic_Astrocytes_In_Vitro_Is_Mediated_by_IL_1_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="29510709" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/29510709/Brain_Specific_Knock_Out_of_Hypoxia_Inducible_Factor_1_Reduces_Rather_Than_Increases_Hypoxic_Ischemic_Damage">Brain-Specific Knock-Out of Hypoxia-Inducible Factor-1 Reduces Rather Than Increases Hypoxic-Ischemic Damage</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="55775890" href="https://independent.academia.edu/CarroleeBarlow">Carrolee Barlow</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Neuroscience, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Brain-Specific Knock-Out of Hypoxia-Inducible Factor-1 Reduces Rather Than Increases Hypoxic-Ischemic Damage","attachmentId":49948246,"attachmentType":"pdf","work_url":"https://www.academia.edu/29510709/Brain_Specific_Knock_Out_of_Hypoxia_Inducible_Factor_1_Reduces_Rather_Than_Increases_Hypoxic_Ischemic_Damage","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/29510709/Brain_Specific_Knock_Out_of_Hypoxia_Inducible_Factor_1_Reduces_Rather_Than_Increases_Hypoxic_Ischemic_Damage"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="52169128" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/52169128/Hypoxia_Inducible_Factor_1_Its_Potential_Role_In_Cerebral_Ischemia">Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35978154" href="https://independent.academia.edu/RamRaghubir">Ram Raghubir</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cellular and Molecular Neurobiology, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia","attachmentId":69558428,"attachmentType":"pdf","work_url":"https://www.academia.edu/52169128/Hypoxia_Inducible_Factor_1_Its_Potential_Role_In_Cerebral_Ischemia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/52169128/Hypoxia_Inducible_Factor_1_Its_Potential_Role_In_Cerebral_Ischemia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" 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You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="117106265" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/117106265/HIF_1%CE%B1_is_neuroprotective_during_the_early_phases_of_mild_hypoxia_in_rat_cortical_neurons">HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="215594584" href="https://independent.academia.edu/BeatrizLopez267">Beatriz Lopez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Experimental 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style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="118200696" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/118200696/Brain_Specific_Knock_Out_of_Hypoxia_Inducible_Factor_1%CE%B1_Reduces_Rather_Than_Increases_Hypoxic_Ischemic_Damage">Brain-Specific Knock-Out of Hypoxia-Inducible Factor-1α Reduces Rather Than Increases Hypoxic-Ischemic Damage</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35809579" href="https://independent.academia.edu/ScottZeitlin">Scott Zeitlin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Neuroscience, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="81213829" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/81213829/Regulation_of_the_Hypoxia_Inducible_Factor_HIF_by_Pro_Inflammatory_Cytokines">Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="221088191" href="https://independent.academia.edu/CheeTeikLee">Chee Teik Lee</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cells, 2021</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines","attachmentId":87336960,"attachmentType":"pdf","work_url":"https://www.academia.edu/81213829/Regulation_of_the_Hypoxia_Inducible_Factor_HIF_by_Pro_Inflammatory_Cytokines","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/81213829/Regulation_of_the_Hypoxia_Inducible_Factor_HIF_by_Pro_Inflammatory_Cytokines"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="13449555" data-sort-order="default"><a class="ds-related-work--title 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data-collection-position="8" data-entity-id="13449499" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13449499/Role_of_hypoxia_inducible_factor_1_in_hypoxia_induced_ischemic_tolerance_in_neonatal_rat_brain">Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32675304" href="https://ucdavis.academia.edu/FrankSharp">Frank Sharp</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Annals of Neurology, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat 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Simpson</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Molecular Sciences</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Transcriptomic Analysis of Human Astrocytes In Vitro Reveals Hypoxia-Induced Mitochondrial Dysfunction, Modulation of Metabolism, and Dysregulation of the Immune Response","attachmentId":66872301,"attachmentType":"pdf","work_url":"https://www.academia.edu/48070017/Transcriptomic_Analysis_of_Human_Astrocytes_In_Vitro_Reveals_Hypoxia_Induced_Mitochondrial_Dysfunction_Modulation_of_Metabolism_and_Dysregulation_of_the_Immune_Response","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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data-author-id="9851264" href="https://independent.academia.edu/jadhavvikram">vikram jadhav</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxic-ischemic injury","attachmentId":48914844,"attachmentType":"pdf","work_url":"https://www.academia.edu/6329384/HIF_1_alpha_inhibition_ameliorates_neonatal_brain_damage_after_hypoxic_ischemic_injury","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/6329384/HIF_1_alpha_inhibition_ameliorates_neonatal_brain_damage_after_hypoxic_ischemic_injury"><span 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class="ds-related-work--metadata ds2-5-body-xs">Journal of Cerebral Blood Flow &amp; Metabolism, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Interleukin-1 and the Interleukin-1 Type 1 Receptor are Essential for the Progressive Neurodegeneration that Ensues Subsequent to a Mild Hypoxic/Ischemic Injury","attachmentId":96236584,"attachmentType":"pdf","work_url":"https://www.academia.edu/93520854/Interleukin_1_and_the_Interleukin_1_Type_1_Receptor_are_Essential_for_the_Progressive_Neurodegeneration_that_Ensues_Subsequent_to_a_Mild_Hypoxic_Ischemic_Injury","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/93520854/Interleukin_1_and_the_Interleukin_1_Type_1_Receptor_are_Essential_for_the_Progressive_Neurodegeneration_that_Ensues_Subsequent_to_a_Mild_Hypoxic_Ischemic_Injury"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="121251045" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/121251045/Inflammatory_cytokine_tumor_necrosis_factor_%CE%B1_suppresses_neuroprotective_endogenous_erythropoietin_from_astrocytes_mediated_by_hypoxia_inducible_factor_2%CE%B1">Inflammatory cytokine tumor necrosis factor α suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2α</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42348890" href="https://independent.academia.edu/%E6%B8%85%E6%96%87%E6%B5%85%E4%BA%95">Kiyofumi Asai</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Neuroscience, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Inflammatory cytokine tumor necrosis factor α suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2α","attachmentId":116179295,"attachmentType":"pdf","work_url":"https://www.academia.edu/121251045/Inflammatory_cytokine_tumor_necrosis_factor_%CE%B1_suppresses_neuroprotective_endogenous_erythropoietin_from_astrocytes_mediated_by_hypoxia_inducible_factor_2%CE%B1","alternativeTracking":true}"><span 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