Alliance Panels - Twist Bioscience

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Mehr erfahren >"> </div> <p>Twist-Workflow zur Gesamtexom-Libraryvorbereitung. Mehr erfahren ></p> </a> </div> <div class="primary-menu__dropdown-content" data-tab-drawer-4 data-index="data-tab-drawer-4"> <div class="primary-menu__dropdown-columns"> <h2> <a href="/de/products/libraries"> <img src="https://www.twistbioscience.com/sites/default/files/2021-05/icon-libraries.png" alt="Variant Libraries"> Variant Libraries </a> </h2> <ul class="sub-nav-columns total-columns-2" data-sub-nav-columns="2"> <li data-sub-nav-column="1"></li> <li data-sub-nav-column="2"></li> </ul> <a href="/de/get-quote" class="main-action">Jetzt bestellen</a> <ul class="menu menu-level-2"> <li class="menu-item" data-column-position=1 data-column-v-weight=1> <a href="/de/tcr-libraries" class="menu-item level-2-category-item"> TCR-Libraries <span class="menu-link-new">Neu</span> </a> </li> <li class="menu-item" data-column-position=1 data-column-v-weight=1> <a href="/de/products/libraries/combinatorial-variant-library" class="menu-item level-2-category-item"> CVL </a> </li> <li 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level-2-category-item"> Flüssigbiopsie </span> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="/de/products/ngs/twist-cfdna-pan-cancer-reference-standards" class=""> cfDNA Pan-Cancer Reference Standards v2<span class="menu-link-new">Neu</span> </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded level-2-category-section" data-column-position=1 data-column-v-weight=1> <div class="level-2-category-section "> <a href="/de/products/ngs/synthetic-viral-controls" class="menu-item menu-item--expanded level-2-category-section level-2-category-item"> Infektionskrankheit </a> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="/de/products/ngs/synthetic-viral-controls?tab=respiratory-virus-controls" class=""> Atemwegsvirus-Kontrollen </a> </li> <li class="menu-item"> <a href="/de/products/ngs/synthetic-viral-controls?tab=sars-cov-2-controls" class=""> SARS-COV-2-Kontrollen </a> </li> <li class="menu-item"> <a 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src="https://www.twistbioscience.com/sites/default/files/2021-05/biopharma-global-213x136%402x_0.png" alt="Lesen Sie unser neues E-Book zur Antikörperidentifizierung und <br>-entwicklung."> </div> <p>Lesen Sie unser neues E-Book zur Antikörperidentifizierung und <br>-entwicklung.</p> </a> </div> </div> </div> </div> </li> <li class="menu-item menu-item--expanded js-primary-menu-wide-mode"> <span title="" id="" name="" rel="" style="" target="" accesskey="">Anwendungen</span> <div data-primary-nav-subnav-container class="wide-menu-sub-navigation"> <div class="primary-nav__drawer-side-bar"> <div class="menu-dropdown menu-dropdown-0"> <ul class="menu menu-level-1" data-tabs > <li class="menu-item menu-item--expanded" data-tab="data-tab-drawer-1" > <a href="https://www.twistbioscience.com/de/good-fight-june-6"> <span>Krebsforschung</span> </a> </li> <li class="menu-item menu-item--large-icon" > <a href="/de/products/storage"> <span>DNA-Datenspeicherung</span> </a> </li> <li 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src="https://www.twistbioscience.com/sites/default/files/2022-06/personalized-sequencing-promo-thumbnail-426x272_0.png" alt="Erfahren Sie mehr über das Twist MRD Rapid 500 Panel."> </div> <p>Erfahren Sie mehr über das Twist MRD Rapid 500 Panel.</p> </a> </div> <div class="primary-menu__dropdown-content" data-tab-drawer-3 data-index="data-tab-drawer-3"> <div class="primary-menu__dropdown-columns"> <h2> <a href="https://www.twistbioscience.com/de/drug-discovery"> Tools für die Arzneimittelforschung </a> </h2> <ul class="sub-nav-columns total-columns-3" data-sub-nav-columns="3"> <li data-sub-nav-column="1"></li> <li data-sub-nav-column="2"></li> <li data-sub-nav-column="3"></li> </ul> <ul class="menu menu-level-2"> <li class="menu-item" data-column-position=1 data-column-v-weight=1> <a href="/de/products/antibody-discovery/single-domain-vhh-antibody-discovery" class="menu-item level-2-category-item"> VHH-Antikörperidentifizierung </a> </li> <li class="menu-item menu-item--expanded 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id="block-twist-barrio-content" class="block block-system block-system-main-block"> <div class="content"> <article data-history-node-id="15046" about="/products/ngs/alliance-panels" class="node node--type-product-child node--view-mode-full product-alliance-panels" data-product="alliance-panels"> <div class="node__content"> <div class="field field--name-field-page-banner field--type-entity-reference-revisions field--label-hidden field__item"> <style> @media (min-width: 768px) { .paragraph--type--banner { background-image: url(https://www.twistbioscience.com/sites/default/files/2021-10/bg-ngs-child%402x%20%281%29_0.png); background-size: cover; } } @media (max-width: 767px) { .paragraph--type--banner { background-image: url(https://www.twistbioscience.com/sites/default/files/2021-10/bg-ngs-child%402x%20%281%29_0.png); background-size: cover; } } </style> <div class="banner paragraph paragraph--type--banner paragraph--view-mode--default"> <div class="banner__content"> <div class="banner-preview-image-wrapper tablet-preview-image"> </div> <div class="container"> <div class="row"> <div class="banner__title col-md-7"> <div class="title"> <h1>Alliance Panels</h1> </div> </div> <div class="header-right-container-wrapper col-md-5"> </div> </div> </div> </div> </div> </div> <div class="system-picker-for-tabs d-md-none" > <div class="title-picker"> <span class="chosen-tab-title"></span> <select> <option value="1">ÜBERSICHT</option> </select> </div> </div> <div class="system-sticky-tabs"> <div class="sticky-wrapper"> <div class="sticky-wrapper-tabs"> <span class="tab-item" data-id="1" data-twist-element="tab" data-twist-location="product-tabs-sticky" data-twist-type="tab">ÜBERSICHT</span> </div> </div> </div> <div class="field field--name-field-pc-tabs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item select-picker-0 active-picker" data-id="0"> <div class="no-custom-show-more paragraph paragraph--type--section-tabs paragraph--view-mode--default array" data-style="array"> <div class="field field--name-field-cp-title field--type-string field--label-hidden field__item" id="overview">ÜBERSICHT</div> <div class="field field--name-field-cp-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="desktop-layer"> <div class="container"> <div class="virtual-wrapper row"> <div class="virtual-region-left col-md-7"> <div class="clearfix component-paragraph paragraph paragraph--type--component-text paragraph--view-mode--default"> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><h3>Übersicht </h3> <p>Einführung der Twist Alliance Panels, einer kuratierten Sammlung hochwertiger Target Enrichment-Panels, die in Zusammenarbeit mit führenden wissenschaftlichen Einrichtungen entwickelt wurden. </p> <p>Durch die Kombination der weltweit führenden Oligonukleotid-Syntheseplattform von Twist mit dem umfassenden Fachwissen unserer wissenschaftlichen Partner stehen Ihnen mit den Twist Alliance Panels gebrauchsfertige Panels zur Verfügung, die Ihre Forschung beschleunigen. Warum Zeit für die Entwicklung von Panels aufwenden, wenn diese Arbeit bereits von Experten für Sie erledigt wurde?</p></div> </div> </div> <div class="virtual-region-right col-md-4"> <div class="virtual-region-nonsticky-col"> <div class="light_green clearfix component-paragraph paragraph paragraph--type--component-callout paragraph--view-mode--default"> <div class="field field--name-field-cp-callout-title field--type-string field--label-hidden field__item">Werden Sie unser Partner</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Wären Sie daran interessiert, ein Panel zu entwickeln, das noch nicht zum Portfolio der Twist Alliance Panels gehört? </p> <p>Werden Sie unser Partner zur <a class="green-link" href="/de/contact">Vermarktung</a></p> <p> </p></div> </div> </div> </div> <div class="clearfix"></div> </div> </div> </div> <div class="mobile-layer"> <div class="clearfix component-paragraph paragraph paragraph--type--component-text paragraph--view-mode--default"> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><h3>Übersicht </h3> <p>Einführung der Twist Alliance Panels, einer kuratierten Sammlung hochwertiger Target Enrichment-Panels, die in Zusammenarbeit mit führenden wissenschaftlichen Einrichtungen entwickelt wurden. </p> <p>Durch die Kombination der weltweit führenden Oligonukleotid-Syntheseplattform von Twist mit dem umfassenden Fachwissen unserer wissenschaftlichen Partner stehen Ihnen mit den Twist Alliance Panels gebrauchsfertige Panels zur Verfügung, die Ihre Forschung beschleunigen. Warum Zeit für die Entwicklung von Panels aufwenden, wenn diese Arbeit bereits von Experten für Sie erledigt wurde?</p></div> </div> <div class="light_green clearfix component-paragraph paragraph paragraph--type--component-callout paragraph--view-mode--default"> <div class="field field--name-field-cp-callout-title field--type-string field--label-hidden field__item">Werden Sie unser Partner</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Wären Sie daran interessiert, ein Panel zu entwickeln, das noch nicht zum Portfolio der Twist Alliance Panels gehört? </p> <p>Werden Sie unser Partner zur <a class="green-link" href="/de/contact">Vermarktung</a></p> <p> </p></div> </div> </div> </div> </div> </div> </div> <div class="field field--name-field-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <section class="section-background" style="background-color:transparent;"> <div class="clearfix component-paragraph paragraph paragraph--type--section paragraph--view-mode--default"> <div class="section-wrapper container"> <div class="row"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h3 style="padding-top: 70px; border-top: 1px solid #DDDDDD;">Erfahren Sie mehr über unsere Panels</h3> <p style="margin-bottom: 70px; line-height: 28px;">Die Twist Alliance Panels wurden entwickelt, um Ihnen einen Vorsprung zu verschaffen, indem sie Fachwissen aus verschiedenen Disziplinen bündeln, um ein überlegenes Target Enrichment für Anwendungen von der Krebsdiagnostik bis hin zum Träger-Screening zu ermöglichen. Wenn keines der Panels Ihren Anforderungen entspricht, kann jedes Panel dort, wo Sie es benötigen, mit einer Spike-in-Abdeckung versehen werden. Wären Sie daran interessiert, mit uns zusammenzuarbeiten, um ein neues Panel zu vermarkten? <a class="green-link" href="/de/contact">Nehmen Sie Kontakt mit uns auf</a>.<br><br /><br><br /> Wir helfen Ihnen dabei, den Zyklus „Entwerfen, Erstellen, Testen, Lernen“ ganz einfach zu überspringen.</p> </div> </div> </div> <div class="alliances-component"> <div class="mobi-menu col-lg-3 col-md-3 col-sm-12 col-12"> <div class="title-wrapper"> <button type="button" class="burger-filter desktop-hide"> Twist Alliance Diversity SNP Panel </button> </div> <div class="link-wrapper filter-form-grid"> <div class="filter-wrapper"> <span class="filter--close desktop-hide"> Menü schließen</span> <ul> <div class="title-wrapper"> <h5>Alliance Panels</h5> </div> <li class=""> <a class="sidebar-link" data-id="tab-0" href="#tab-0">Twist Alliance Diversity SNP Panel</a> </li> <li class=""> <a class="sidebar-link" data-id="tab-1" href="#tab-1">Twist Alliance-Pan-Krebs-Methylierungs-Panel – 1,5 MB</a> </li> <li class=""> <a class="sidebar-link" data-id="tab-2" href="#tab-2">Twist Alliance Clinical Research Exome-Kit – 34,9 MB</a> </li> <li class=""> <a class="sidebar-link" data-id="tab-3" href="#tab-3">Twist Alliance VCGS Exome – 40,1 MB</a> </li> <li class=""> <a class="sidebar-link" data-id="tab-4" href="#tab-4">Twist Alliance Canine Exome – 40,5 MB</a> </li> <li class=""> <a class="sidebar-link" data-id="tab-5" href="#tab-5">Twist Alliance CNTG Exome – 41 MB </a> </li> <li class=""> <a class="sidebar-link" data-id="tab-6" href="#tab-6">Twist Alliance CNTG Rare Disease Panel – 7,6 MB</a> </li> <li class=""> <a class="sidebar-link" data-id="tab-7" href="#tab-7">Twist Alliance CNTG Hereditary Oncology Panel – 0,2 MB</a> </li> <li class=""> <a class="sidebar-link" data-id="tab-8" href="#tab-8">Twist Human Ancient DNA Panel</a> </li> </ul> </div> </div> </div> <div class="filter-wrapper col-lg-8 col-md-8 col-sm-12 col-12 col-right"> <div class="field field--name-field-alliances field--type-entity-reference field--label-hidden"> <div class="field__items"> <div id="tab-0" class="tab-data tab-content"> <article data-history-node-id="15026" about="/node/15026" class="node node--type-alliances node--view-mode-alliances"> <h4> <span class="field field--name-title field--type-string field--label-hidden">Twist Alliance Diversity SNP Panel</span> </h4> <div class="node__content"> <div class="field field--name-field-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--alliances-sections paragraph--view-mode--default"> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--html paragraph--view-mode--default"> <div style="background-color:transparent"> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p>Ein weit verbreitetes Problem herkömmlicher Genotypisierungstools ist ihre Ausrichtung auf eine kleine Anzahl von Ethnien, wodurch erhebliche Teile der Menschheit in klassischen Genotypisierungs-Workflows unterrepräsentiert sind. So bieten beispielsweise Microarray-Plattformen nur fest vorgegebene Inhalte, die gelegentlich aktualisiert werden, wodurch sich die Problematik weiter verschärft.<br><br /> <br><br /> Forscher können diese Ineffizienzen und Ungleichheiten beseitigen, indem sie Target-Capture-basierte NGS-Workflows mit Sondenpanels verwenden, die auf Vielfalt und Flexibilität ausgelegt sind.<br><br /> <br><br /> Als Teil von Twists wachsendem Targeted-GBS-Portfolio bietet das Twist Diversity SNP Panel Forschern einen neuen, flexiblen und ethnisch neutralen Goldstandard für GBS.<br><br /> <br><br /> Wissenschaftler haben die Wahl, ob sie das Panel als eigenständiges Genotypisierungs-Panel oder als Spike-in für das Twist Human<b data-stringify-type="bold"><i data-stringify-type="italic"> </i></b>Comprehensive Exome Panel verwenden möchten. Das Design ist zudem anpassbar – zusätzliche Sonden, die die gewünschten Regionen abdecken, können auf der DNA-Syntheseplattform von Twist synthetisiert werden.<br><br /> <br><br /> Das Twist Diversity SNP Panel wurde in Partnerschaft mit Leitern des Regeneron Genetics Center kuratiert. Dieses Panel wurde so konfiguriert, dass es vollständig in bestehende, komplett automatisierte Exom-Verarbeitungs-Workflows integriert werden kann, und liefert Basenaufrufe und imputierte Varianten.</p> <p>Genotyp-Imputationen können mit verfügbaren Open-Source-Tools berechnet werden. Um eine Kopie unseres Imputationsleitfadens zu erhalten und mit der Arbeit mit den Imputationsanalyse-Tools zu beginnen, kontaktieren Sie bitte unseren <a class="green-link" href="/de/contact">Kundendienst</a>.<br><br />  </p> <p><em>Hinweis: Der Inhalt des Diversity SNP Panel wurde noch nicht vollständig durch den gesamten Twist-Arbeitsablauf validiert. Bitte wenden Sie sich an den Kundendienst, um Empfehlungen bei der Assay-Einrichtung zu erhalten.</em></p> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">SONDEN </p> <span class="spec-data"> 640k</span> </div> <div class="spec clearfix"> <p class="spec-label">ABGEDECKTE SNPs </p> <span class="spec-data"> 1.4M</span> </div> <div class="spec clearfix"> <p class="spec-label">SENSITIVITÄT </p> <span class="spec-data"> Imputation der meisten Varianten bis zu einem MAF von 0,1 % oder weniger</span> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4>Ressourcen</h4> <p><a class="green-link" href="https://www.twistbioscience.com/de/resources/application-note/capture-based-snp-genotyping-twist-target-enrichment-panels">Anwendungshinweis: Capture-basierte SNP-Genotypisierung mit Twist Target Enrichment Panels</a></p> <p><a class="green-link" href="/de/resources/webinar/sequencing-100000s-humans-lessons-challenges-hopes">Webinar: Sequenzierung von Hunderttausenden von Menschen: Lessons, Challenges, Hopes – Gonçalo Abecasis, Regeneron Genetics Center</a></p></div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4 style="margin-bottom: -25px;">Bestellinformationen</h4> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">104374</p> <span class="spec-data">Twist Diversity SNP Panel, 2 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">104375</p> <span class="spec-data">Twist Diversity SNP Panel, 12 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">104376</p> <span class="spec-data">Twist Diversity SNP Panel, 96 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">104393</p> <span class="spec-data">Twist Diversity SNP Panel, 16 Proben vollständiges Kit mit Standard Hyb</span> </div> <div class="spec clearfix"> <p class="spec-label">104394</p> <span class="spec-data">Twist Diversity SNP Panel, 96 Proben vollständiges Kit mit Standard Hy</span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article></div> <div id="tab-1" class="tab-data tab-content"> <article data-history-node-id="15031" about="/node/15031" class="node node--type-alliances node--view-mode-alliances"> <h4> <span class="field field--name-title field--type-string field--label-hidden">Twist Alliance-Pan-Krebs-Methylierungs-Panel – 1,5 MB</span> </h4> <div class="node__content"> <div class="field field--name-field-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--alliances-sections paragraph--view-mode--default"> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--html paragraph--view-mode--default"> <div style="background-color:transparent"> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p><span><span><span><span><span><span>Methylation Sequencing ist ein sensitives Tool zum Nachweis und zur Rückverfolgung des Ursprungs von Krebszellen. Aber wie bei jedem Sequenzierungsprojekt ist ein Kompromiss bezüglich der Breite und Tiefe der Abdeckung einzugehen. Wenn Sie bereit sind, den Schwerpunkt auf den Nachweis krebsspezifischer Methylierungsmuster zu legen, ist dies das richtige Panel für Sie. Die Experten von AnchorDx haben in Zusammenarbeit mit Twist ein maßgeschneidertes Target Enrichment-Panel entwickelt, das sich gezielt auf diejenigen Targets konzentriert, die für 31 verschiedene Krebsarten relevant sind. </span></span></span></span></span></span></p> <p><span><span><span><span><span><span>Das Twist Alliance Pan-Krebs-Methylierungspanel – 1,5 MB bietet eine umfassende Abdeckung klinisch relevanter Targets, die die Untersuchung von Methylierungsmustern ermöglichen, die für die Krebsfrüherkennung und -diagnose anhand von Tumor- und Flüssigbiopsieproben relevant sein können. </span></span></span></span></span></span>Dieses Panel wurde in Zusammenarbeit mit den Experten von AnchorDx<span><span><span><span><span><span> entwickelt und mit der weltweit führenden Oligonukleotid-Syntheseplattform von Twist erstellt. Es bietet eine hohe On-Target-Rate und eine hohe Homogenität und wurde mit dem Twist-Methylierungs-Workflow anhand von Flüssigbiopsie-Proben von Brustkrebs, Darmkrebs und nicht-kleinzelligem Lungenkrebs validiert.</span></span></span></span></span></span></p> <p>Möchten Sie sehen, welche Gene abgedeckt sind? Kontaktieren Sie uns unter <a href="/de/cdn-cgi/l/email-protection#8ceff9fff8e3e1e9fefff9fcfce3fef8ccf8fbe5fff8eee5e3ffefe5e9e2efe9a2efe3e1" target="_blank">customersupport@<wbr>twistbioscience.com</a></p> <h4><strong><span><span><span><span><span><span>Panel-Design</span></span></span></span></span></span></strong></h4> <ul> <li><span><span><span><span><span><span>31 Krebsarten, 47 Krankheitsentitäten, basierend auf der TCGA-Datenbank</span></span></span></span></span></span></li> <li><span><span><span><span><span><span>13.090 Sonden </span></span></span></span></span></span></li> <li><span><span><span><span><span><span>126.000 beteiligte CpG-Stellen</span></span></span></span></span></span></li> <li><span><span><span><span><span><span>Ca. 12.000 differenziert methylierte Regionen (DMRs)</span></span></span></span></span></span></li> <li><span><span><span><span><span><span>9.000 von 12.000 (74 %) überschnitten sich mit den CpG-Inseln</span></span></span></span></span></span></li> </ul> <p><span><span><span><span><em><span>Hinweis: Das Twist Alliance Pan-Krebs-Methylierungs-Panel – 1,5 MB ist nicht ISO-13485 zertifiziert.</span></em></span></span></span></span></p> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4>Ressourcen</h4> <p><a class="green-link" href="https://www.twistbioscience.com/de/resources/bed-file/twist-alliance-pan-cancer-methylation-panel-15mb-bed-files">Twist Alliance Pan-Krebs-Methylierungs-Panel Ressourcen-Dateien</a></p></div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4 style="margin-bottom: -25px;">Bestellinformationen</h4> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">104694</p> <span class="spec-data">Twist Alliance-Pan-Krebs-Methylierungs-Panel – 1,5 MB, 2 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">104695</p> <span class="spec-data">Twist Alliance-Pan-Krebs-Methylierungs-Panel – 1,5 MB, 12 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">104696</p> <span class="spec-data">Twist Alliance-Pan-Krebs-Methylierungs-Panel – 1,5 MB, 96 Reaktionen</span> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-title">Twist Methylierungs-Workflow</div> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">101976 </p> <span class="spec-data"> NEBNext® EM-seq™ Kit für Twist Targeted Methylation Sequencing, 96 Proben*</span> </div> <div class="spec clearfix"> <p class="spec-label">103557 </p> <span class="spec-data"> Twist Methylation Enhancer, 12 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">100578 </p> <span class="spec-data"> Twist Universal Blockers, 12 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">100983 </p> <span class="spec-data"> Twist Binding and Purification Beads Kit, 12 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">101174 </p> <span class="spec-data"> Twist Fast Hybridization and Wash Kit, 12 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">103496 </p> <span class="spec-data"> Twist Targeted Methylation Sequencing Workflow, 96x12 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label"> </p> <span class="spec-data"> </span> </div> <div class="spec clearfix"> <p class="spec-label"> </p> <span class="spec-data"> *2 Reaktions- und 12 Reaktionsgrößen ebenfalls für die Anreicherung erhältlich. </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article></div> <div id="tab-2" class="tab-data tab-content"> <article data-history-node-id="15041" about="/node/15041" class="node node--type-alliances node--view-mode-alliances"> <h4> <span class="field field--name-title field--type-string field--label-hidden">Twist Alliance Clinical Research Exome-Kit – 34,9 MB</span> </h4> <div class="node__content"> <div class="field field--name-field-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--alliances-sections paragraph--view-mode--default"> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--html paragraph--view-mode--default"> <div style="background-color:transparent"> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p>Twist Alliance Clinical Research Exome unterstützt die Broad Institute Genomics-Plattform und wurde anhand validierter Daten aus klinischen Patientenproben entwickelt. Das Panel nutzt die flexible NGS-Plattform von Twist, um die Inhalte einfach und schnell anzupassen. Das Ergebnis ist eine umfassende Untersuchung des Exoms mit zusätzlicher Anreicherung klinisch relevanter Bereiche des Genoms, die mit Krebs sowie seltenen und erblichen Krankheiten in Verbindung stehen. Durch die Nutzung der klassenbesten Homogenität der Twist-NGS-Sonden ermöglicht der Assay eine Kosten- und Durchsatz-Effizienz pro Probe, die es Broad ermöglicht hat, bereits 250.000 Proben zu analysieren, wodurch Broad nun eine Spitzenposition im Bereich der Exom-Sequenzierung einnimmt.</p> <p>Das vollständige Design dieses Panels umfasst das Twist-Core-Exom, das mitochondriale Genom und zusätzliche validierte codierende und nicht-exonische Regionen von Interesse wie die ACMG73-Gene, eine zusätzliche Abdeckung von Regionen aus OMIM und COSMIC sowie spezifische, von Broad definierte Targets. </p> <p><em>Hinweis: Der Inhalt des Twist Alliance Clinical Research Exome – 34,9 MB wurde noch nicht vollständig über den gesamten Twist-Workflow validiert. Bitte wenden Sie sich an den Kundendienst, um Empfehlungen bei der Assay-Einrichtung zu erhalten. </em></p> <p><em>Hinweis: Das Twist Alliance Clinical Research Exome – 34,9 MB ist nicht ISO-13485 zertifiziert.</em></p> <p> </p> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4 style="margin-bottom: -25px;">Bestellinformationen</h4> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">104032</p> <span class="spec-data">Twist Alliance Clinical Research Exome-Kit – 34,9 MB, 2 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">104033</p> <span class="spec-data">Twist Alliance Clinical Research Exome-Kit – 34,9 MB, 12 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">104034</p> <span class="spec-data">Twist Alliance Clinical Research Exome-Kit – 34,9 MB, 96 Reaktionen</span> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4>Ressourcen</h4> <p><a class="green-link" href="https://www.twistbioscience.com/de/resources/bed-file/twist-alliance-clinical-research-exome-349-mb-bed-files">[.bed-Dateien] Twist Alliance Clinical Research Exome</a></p></div> </div> </div> </div> </div> </div> </div> </div> </div> </article></div> <div id="tab-3" class="tab-data tab-content"> <article data-history-node-id="15036" about="/node/15036" class="node node--type-alliances node--view-mode-alliances"> <h4> <span class="field field--name-title field--type-string field--label-hidden">Twist Alliance VCGS Exome – 40,1 MB</span> </h4> <div class="node__content"> <div class="field field--name-field-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--alliances-sections paragraph--view-mode--default"> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--html paragraph--view-mode--default"> <div style="background-color:transparent"> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p>In Fällen, in denen Routinetests keine Diagnose liefern konnten, wenden Ärzte zur weiteren Klärung häufig DNA-Sequenzierungspanels an, insbesondere wenn eine erbliche Krankheit vermutet wird. Doch ohne fachkundige Beratung kann sich die Wahl des geeigneten Panels oft schwierig gestalten.<br><br /> Basierend auf jahrzehntelanger Erfahrung in der klinischen Genomik hat Victorian Clinical Genetics Services (VCGS) in Zusammenarbeit mit Twist ein diagnostisches Panel entwickelt – Twist Alliance VCGS Exome – 40,1 MB – das das gesamte Exom abdeckt, wobei die Abdeckung klinisch relevanter Gene (Mendeliom) gezielt erhöht wurde. Bei der Entwicklung dieses Panels wurde besonders darauf geachtet, dass auch klinisch relevante Loci erfasst werden, die außerhalb der herkömmlicherweise von Exomen erfassten gencodierenden Regionen liegen (d. h. bekannte pathogene Loci in nichtcodierenden Regionen).<br><br /> Das Twist Alliance VCGS Exome – 40,1 MB-Panel ist ein erstklassiges, hochgradig einheitliches Panel, das die Identifizierung von Allelen, die mit erblichen Krankheiten verbunden sind, vereinfachen kann, sei es durch Träger-Screening oder prä- und postnatale Tests.</p> <p><em>Hinweis: Der Inhalt des Twist VCGS Exome – 40,1 MB wurde noch nicht vollständig über den gesamten Twist-Workflow validiert. Bitte wenden Sie sich an den Kundendienst, um Empfehlungen bei der Assay-Einrichtung zu erhalten.</em></p> <p><em>Hinweis: Das Twist Alliance VCGS Exome – 40,1 MB ist nicht ISO-13485 zertifiziert.</em></p> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">Gesamtzahl Sonden </p> <span class="spec-data"> 425.4K</span> </div> <div class="spec clearfix"> <p class="spec-label">Umfasst das Twist Comprehensive Exome mit </p> <span class="spec-data"> 394.100 Sonden</span> </div> <div class="spec clearfix"> <p class="spec-label">und VCGS-kuratierte </p> <span class="spec-data"> 31.300 Sonden</span> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4 style="margin-bottom: -25px;">Bestellinformationen</h4> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">104282</p> <span class="spec-data">Twist Alliance VCGS Exome – 40,1 MB, 2-Reaktionskit</span> </div> <div class="spec clearfix"> <p class="spec-label">104283</p> <span class="spec-data">Twist Alliance VCGS Exome – 40,1 MB, 12-Reaktionskit</span> </div> <div class="spec clearfix"> <p class="spec-label">104284</p> <span class="spec-data">Twist Alliance VCGS Exome – 40,1 MB, 96-Reaktionskit</span> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4>Ressourcen</h4> <p><a class="green-link" href="https://www.twistbioscience.com/de/resources/bed-file/twist-alliance-vcgs-exome-401mb-bed-files">[.bed-Dateien] Twist Alliance VCGS Exome – 40,1 MB</a></p></div> </div> </div> </div> </div> </div> </div> </div> </div> </article></div> <div id="tab-4" class="tab-data tab-content"> <article data-history-node-id="16736" about="/node/16736" class="node node--type-alliances node--view-mode-alliances"> <h4> <span class="field field--name-title field--type-string field--label-hidden">Twist Alliance Canine Exome – 40,5 MB</span> </h4> <div class="node__content"> <div class="field field--name-field-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--alliances-sections paragraph--view-mode--default"> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><p><strong>Nur zu Forschungszwecken. Nicht für die Verwendung in diagnostischen Verfahren bestimmt.</strong></p> <p>Das Verständnis der genetischen Variation zwischen Hunderassen ist von entscheidender Bedeutung für das Verständnis der genetischen Regulation von Merkmalen sowie der Grundlage und des Verlaufs von Krankheiten bei Hunden. Folglich sind umfassende Genpanels wie Exome von zentraler Bedeutung für die Verbesserung der Veterinärdiagnostik und der damit verbundenen klinischen Medizin. Diese Arten von NGS-Panels werden auch die Forschung zur Entwicklung eines tieferen Verständnisses von Krebserkrankungen bei Hunden und potenziellen Therapeutika beschleunigen.</p> <p>Das Twist Alliance Canine Exome, das in Zusammenarbeit mit dem Karlsson-Labor des Broad Institute entwickelt wurde, ist genau das richtige Tool für die Genomforschung bei Hunden. Weiterhin hat sich herausgestellt, dass die Genomforschung bei Hunden auch für die humanmedizinische Forschung von Nutzen ist, da genetische Ähnlichkeiten zwischen menschlichen und hündischen Tumoren wie CNVs, differentiellen Genexpressionen und strukturellen Chromosomenanomalien festgestellt wurden1.</p> <p>Das Twist Alliance Canine Exom-Panel wurde mit den folgenden Zielsetzungen entwickelt:</p> <ol> <li>Abdeckung kodierender Exone von Hundegenen</li> <li>Ermöglichung vergleichender genomischer Studien zwischen dem Genom von Hund und Mensch</li> <li>Einschluss von Regionen mit bekannter Bedeutung für menschliche Krebserkrankungen</li> <li>Ermöglichung kostengünstiger Tiefensequenzierung</li> </ol> <p>Das Panel enthält mehr als 17.000 Gene/Targets auf der Grundlage von CanFam3.1, mit zusätzlicher Abdeckung von Genen/Targets, die bei Krebs bei Hunden eine Rolle spielen. <br><br />  </p> <table width="100%"> <tbody> <tr class="thead-gray"> <td class="xl65">Gene</td> <td class="xl65" wi> <p>Assoziierte<br><br /> COSMIC<br><br />-Mutationen</p> </td> <td class="xl65">Gene</td> <td class="xl65">Assoziierte<br><br /> COSMIC<br><br />-Mutationen</td> <td class="xl65">Gene</td> <td class="xl65">Assoziierte<br><br /> COSMIC<br><br />-Mutationen</td> </tr> <tr> <td class="xl66">ABL1</td> <td class="xl67">19</td> <td class="xl66">HRAS</td> <td class="xl67">26</td> <td class="xl66">TET2</td> <td class="xl67">16</td> </tr> <tr> <td class="xl66">AKT1</td> <td class="xl67">6</td> <td class="xl66">MPL</td> <td class="xl67">0</td> <td class="xl66">FAS</td> <td class="xl67">3</td> </tr> <tr> <td class="xl66">ERBB2</td> <td class="xl67">19</td> <td class="xl66">SMAD4</td> <td class="xl67">31</td> <td class="xl66">STAT5B</td> <td class="xl67">4</td> </tr> <tr> <td class="xl66">GNAS</td> <td class="xl67">12</td> <td class="xl66">ATM</td> <td class="xl67">24</td> <td class="xl66">DNMT3A</td> <td class="xl67">6</td> </tr> <tr> <td class="xl66">MET</td> <td class="xl67">18</td> <td class="xl66">FBXW7</td> <td class="xl67">25</td> <td class="xl66">STAT3</td> <td class="xl67">6</td> </tr> <tr> <td class="xl66">RB1</td> <td class="xl67">18</td> <td class="xl66">IDH1</td> <td class="xl67">15</td> <td class="xl66">CREBBP</td> <td class="xl67">9</td> </tr> <tr> <td class="xl66">CCR4</td> <td class="xl67">3</td> <td class="xl66">NOTCH1</td> <td class="xl67">20</td> <td class="xl66">RHOA</td> <td class="xl67">1</td> </tr> <tr> <td class="xl66">MYC</td> <td class="xl67">5</td> <td class="xl66">SMARCB1</td> <td class="xl67">11</td> <td class="xl66">CHEK2</td> <td class="xl67">5</td> </tr> <tr> <td class="xl66">EGFR</td> <td class="xl67">123</td> <td class="xl66">BRAF</td> <td class="xl67">77</td> <td class="xl66">PRDM1</td> <td class="xl67">6</td> </tr> <tr> <td class="xl66">GNAQ</td> <td class="xl67">6</td> <td class="xl66">FGFR1</td> <td class="xl67">2</td> <td class="xl66">CDKN2A</td> <td class="xl67">108</td> </tr> <tr> <td class="xl66">KRAS</td> <td class="xl67">63</td> <td class="xl66">IDH2</td> <td class="xl67">12</td> <td class="xl66">FGFR3</td> <td class="xl67">17</td> </tr> <tr> <td class="xl66">PTPN11</td> <td class="xl67">28</td> <td class="xl66">NPM1</td> <td class="xl67">28</td> <td class="xl66">JAK3</td> <td class="xl67">6</td> </tr> <tr> <td class="xl66">CD28</td> <td class="xl67">3</td> <td class="xl66">SMO</td> <td class="xl67">5</td> <td class="xl66">PDGFRA</td> <td class="xl67">26</td> </tr> <tr> <td class="xl66">PLCG1</td> <td class="xl67">3</td> <td class="xl66">CDH1</td> <td class="xl67">7</td> <td class="xl66">STK11</td> <td class="xl67">22</td> </tr> <tr> <td class="xl66">ALK</td> <td class="xl67">8</td> <td class="xl66">FGFR2</td> <td class="xl67">8</td> <td class="xl66">CTNNB1</td> <td class="xl67">73</td> </tr> <tr> <td class="xl66">ERBB4</td> <td class="xl67">13</td> <td class="xl66">JAK2</td> <td class="xl67">5</td> <td class="xl66">GNA11</td> <td class="xl67">5</td> </tr> <tr> <td class="xl66">HNF1A</td> <td class="xl67">10</td> <td class="xl66">NRAS</td> <td class="xl67">35</td> <td class="xl66">KIT</td> <td class="xl67">139</td> </tr> <tr> <td class="xl66">MLH1</td> <td class="xl67">1</td> <td class="xl66">SRC</td> <td class="xl67">1</td> <td class="xl66">PTEN</td> <td class="xl67">146</td> </tr> <tr> <td class="xl66">RET</td> <td class="xl67">17</td> <td class="xl66">JAK1</td> <td class="xl67">12</td> <td class="xl66">VHL</td> <td class="xl67">124</td> </tr> <tr> <td class="xl66">APC</td> <td class="xl67">164</td> <td class="xl66">IL7R</td> <td class="xl67">4</td> <td class="xl66">CSF1R</td> <td class="xl67">8</td> </tr> <tr> <td class="xl66">EZH2</td> <td class="xl67">11</td> <td class="xl66">IL2RG</td> <td class="xl67">3</td> <td class="xl66">FLT3</td> <td class="xl67">30</td> </tr> <tr> <td class="xl66">TP53</td> <td class="xl67">1087</td> <td class="xl66">TNFAIP3</td> <td class="xl67">9</td> <td class="xl66">KDR</td> <td class="xl67">11</td> </tr> <tr> <td class="xl66">FYN</td> <td class="xl67">3</td> <td class="xl66">PIK3CA</td> <td class="xl67">97</td> <td class="xl66"> </td> <td class="xl66"> </td> </tr> </tbody> </table> <p><br><br /> Die obige Tabelle zeigt 50 solcher Targets zusammen mit den COSMIC-Mutationen, die mit jedem dieser Gene assoziiert sind (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978258/) – diese Gene wurden für eine höhere Abdeckung 2x gekachelt. FOXA1 und TERT Promoter wurden 4x gekachelt. Alle anderen Regionen wurden gemäß unseren Standardverfahren mit 1x gekachelt.</p> <p>Mit den kuratierten Inhalten der weltweit führenden Krebsforscher für Hunde in Kombination mit der robusten Panel-Performance von Twist bietet das Twist Alliance Canine Exom das optimale Tool für Forscher, die sowohl Hundekrankheiten als auch seltene menschliche Krankheiten untersuchen.</p> <p>1 Overgaard,N.H.,Fan,T.M.,Schachtschneider,K.M.,Principe,D.R.,Schook,L.B.,& Jungersen, G. (2018). Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research. ILAR journal, 59(3), 247–262.</p> <p><em>Hinweis: Das Twist Alliance Canine Exom – 40,5 MB ist nicht ISO-13485-zertifiziert.</em></p> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4 style="margin-bottom: -25px;">Bestellinformationen</h4> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">105305 </p> <span class="spec-data"> Twist Alliance Canine Exome – 40,5 Mb, 2 Reaktionen, Kit</span> </div> <div class="spec clearfix"> <p class="spec-label">105306 </p> <span class="spec-data"> Twist Alliance Canine Exome – 40,5 Mb, 12 Reaktionen, Kit</span> </div> <div class="spec clearfix"> <p class="spec-label">105307 </p> <span class="spec-data"> Twist Alliance Canine Exome – 40,5 Mb, 96 Reaktionen, Kit</span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article></div> <div id="tab-5" class="tab-data tab-content"> <article data-history-node-id="23906" about="/node/23906" class="node node--type-alliances node--view-mode-alliances"> <h4> <span class="field field--name-title field--type-string field--label-hidden">Twist Alliance CNTG Exome – 41 MB </span> </h4> <div class="node__content"> <div class="field field--name-field-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--alliances-sections paragraph--view-mode--default"> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--html paragraph--view-mode--default"> <div style="background-color:transparent"> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p>Nur zu Forschungszwecken. Nicht für die Verwendung in diagnostischen Verfahren bestimmt.</p> <p>Die Diagnose seltener Erkrankungen stellt Ärzte vor viele Herausforderungen und kann Patienten auf eine lange diagnostische Reise führen. DNA-Sequenzierungspanels können Ärzten Antworten auf diese Herausforderungen und Lösungen für Patienten bieten. Als führendes Unternehmen in der Diagnostik seltener Erkrankungen hat sich CENTOGENE mit Twist zusammengeschlossen, um eine Reihe von Target Enrichment-Capture-Panels zu entwickeln, die umfassende Tools zur Unterstützung der Diagnose seltener Erkrankungen und Erbkrebs bieten.  </p> <p>Das Twist Alliance CNTG Exome – 41 MB bietet eine sehr einheitliche Abdeckung des gesamten Exoms sowie eine vollständige Abdeckung des mitochondrialen Genoms. Die Kombination von Erkenntnissen aus der Bio-/Datenbank von CENTOGENE mit der außergewöhnlichen Omics-Technologie, dem Twist Alliance CNTG Exome – 41 MB, erhöht die diagnostische Ausbeute im Vergleich zur standardmäßigen vollständigen Exom-Sequenzierung und deckt ein breites Spektrum von Erkrankungen ab, das mehr als 7.000 seltene Erkrankungen umfasst.  </p> <p>Hinweis: Das Twist Alliance CNTG Exome – 41 MB ist nicht ISO-13485-zertifiziert.</p> <h4>Panel-Informationen</h4> <ul> <li aria-level="1"> <p>Gesamtzahl Sonden 483.000</p> </li> <li aria-level="1"> <p>Twist Human Comprehensive Exome 396.100</p> </li> <li aria-level="1"> <p>Twist Mitochondrial Panel 139</p> </li> <li aria-level="1"> <p>Twist Alliance Centogene Rare Disease Panel 78.800</p> </li> <li aria-level="1"> <p>Centogene Spike-In 7.800</p> </li> </ul> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4 style="margin-bottom: -25px;">Bestellinformationen</h4> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-title">Twist Alliance CNTG Exome – 41 MB </div> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">105459</p> <span class="spec-data">Twist Alliance CNTG Exome – 41 MB, 2 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">105461</p> <span class="spec-data">Twist Alliance CNTG Exome – 41 MB, 12 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">105462</p> <span class="spec-data">Twist Alliance CNTG Exome – 41 MB, 96 Reaktionen</span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article></div> <div id="tab-6" class="tab-data tab-content"> <article data-history-node-id="23911" about="/node/23911" class="node node--type-alliances node--view-mode-alliances"> <h4> <span class="field field--name-title field--type-string field--label-hidden">Twist Alliance CNTG Rare Disease Panel – 7,6 MB</span> </h4> <div class="node__content"> <div class="field field--name-field-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--alliances-sections paragraph--view-mode--default"> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--html paragraph--view-mode--default"> <div style="background-color:transparent"> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p style="line-height: 1.38;">Nur zu Forschungszwecken. Nicht für die Verwendung in diagnostischen Verfahren bestimmt.</p> <p>Das Twist Alliance CNTG Rare Disease Panel umfasst mehr als 2.500 relevante, mit seltenen Erkrankungen assoziierte Gene und deckt ≥ 99,5 % der Zielregionen ab. Dadurch bietet es Wissenschaftlern ein leichteres Instrument zur Erfassung der entscheidenden Abdeckung seltener Erkrankungen im CNTG Exome ohne den gesamten Fußabdruck. Dieses Panel kann zum Nachweis von Genen verwendet werden, die u. a. mit seltenen behandelbaren Erkrankungen, im frühen Kindesalter einsetzenden Erkrankungen, Herzerkrankungen, neurodegenerativen Erkrankungen, Skelettanomalien und Stoffwechselstörungen in Zusammenhang stehen.  </p> <ul> <li aria-level="1"> <p>Twist Alliance Centogene Rare Disease Panel 78.800 Sonden</p> </li> </ul> <p>Hinweis: Das Twist Alliance CNTG Rare Disease Panel – 7,6 MB ist nicht ISO-13485-zertifiziert.</p> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4 style="margin-bottom: -25px;">Bestellinformationen</h4> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-title">Twist Alliance CNTG Rare Disease Panel – 7,6 MB</div> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">105466</p> <span class="spec-data">Twist Alliance CNTG Rare Disease Panel – 7,6 MB, 2 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">105467</p> <span class="spec-data">Twist Alliance CNTG Rare Disease Panel – 7,6 MB, 12 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">105468</p> <span class="spec-data">Twist Alliance CNTG Rare Disease Panel – 7,6 MB, 96 Reaktionen</span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article></div> <div id="tab-7" class="tab-data tab-content"> <article data-history-node-id="23916" about="/node/23916" class="node node--type-alliances node--view-mode-alliances"> <h4> <span class="field field--name-title field--type-string field--label-hidden">Twist Alliance CNTG Hereditary Oncology Panel – 0,2 MB</span> </h4> <div class="node__content"> <div class="field field--name-field-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--alliances-sections paragraph--view-mode--default"> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--html paragraph--view-mode--default"> <div style="background-color:transparent"> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p style="line-height: 1.38;">Nur zu Forschungszwecken. Nicht für die Verwendung in diagnostischen Verfahren bestimmt.</p> <p>Das Twist Alliance CNTG Hereditary Oncology Panel umfasst 72 ausgewählte krebsassoziierte Gene und deckt ≥ 99,5 % der Zielregionen ab. Das Panel kann verwendet werden, um die genetische Veranlagung für erbliche Tumore zu identifizieren, einschließlich Brustkrebs, Magen-Darm-Tumoren, Li-Fraumeni-Syndrom, MEN1, MEN2, Paragangliome und andere.</p> <p>Hinweis: Das Twist Alliance CNTG Hereditary Oncology Panel – 0,2 MB ist nicht ISO-13485-zertifiziert.</p> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4 style="margin-bottom: -25px;">Bestellinformationen</h4> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-title">Twist Alliance CNTG Hereditary Oncology Panel – 0,2 MB</div> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">105493</p> <span class="spec-data">Twist Alliance CNTG Hereditary Oncology Panel – 0,2 MB, 2 Reaktionskit</span> </div> <div class="spec clearfix"> <p class="spec-label">105494</p> <span class="spec-data">Twist Alliance CNTG Hereditary Oncology Panel – 0,2 MB, 12 Reaktionskit</span> </div> <div class="spec clearfix"> <p class="spec-label">105495</p> <span class="spec-data">Twist Alliance CNTG Hereditary Oncology Panel – 0,2 MB, 96 Reaktionskit </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article></div> <div id="tab-8" class="tab-data tab-content"> <article data-history-node-id="31381" about="/node/31381" class="node node--type-alliances node--view-mode-alliances"> <h4> <span class="field field--name-title field--type-string field--label-hidden">Twist Human Ancient DNA Panel</span> </h4> <div class="node__content"> <div class="field field--name-field-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--alliances-sections paragraph--view-mode--default"> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><p>Das Ancient Human DNA Panel wurde in Zusammenarbeit mit dem Labor von David Reich an der Harvard University entwickelt, um die genetische Variation in alten DNA-Proben zu untersuchen, die typischerweise aus Knochen und Zähnen gewonnen werden. Das Gremium zielt auf 1,35 Millionen SNPs ab, die als Teilmenge alle 1,23 Millionen polymorphen Stellen im menschlichen Genom umfassen, was ursprünglich in Fu et al. Nature 2015 veröffentlicht wurde, und was die Kompatibilität neuer Daten gewährleistet, die mit dem Twist Human Ancient DNA Panel anhand vieler tausend alter Individuen generiert wurden. Dieses Panel ermöglicht Daten im Genom-Maßstab zu deutlich geringeren Sequenzierungskosten im Vergleich zur Shotgun-Sequenzierung, da es menschliche DNA-Fragmente im hohen Maße anreichern kann.</p> <p>Dieses ursprüngliche Panel wurde mithilfe der doppelsträngigen Capture-Sonden und Hybridisierungs-Capture-Reagenzien von Twist optimiert, was zu einer hohen Genomabdeckung und einer verringerten Allelverzerrung führte, wie bei Rohland, Mallick et al. Genome Research 2022, PMID: 36517229 zu sehen ist.</p> <p>Bitte wenden Sie sich an den <a href="/de/contact">Twist Kundendienst</a>, um Empfehlungen bei der Assay-Einrichtung zu erhalten.</p> <p>Hinweis: Das Twist Alliance Ancient Human DNA Panel ist nicht nach ISO-13485 zertifiziert</p> <p> </p> <h4 style="margin-bottom: -25px;"><strong>Bestellinformationen</strong></h4> </div> </div> </div> </div> <div class="field__item"> <div class="clearfix component-paragraph paragraph paragraph--type--component-table paragraph--view-mode--default"> <div class="table-title">Twist Alliance Ancient Human DNA Panel</div> <div class="table-data"> <div class="spec clearfix"> <p class="spec-label">107479</p> <span class="spec-data">Twist Alliance Ancient Human DNA Panel - 13 Mb, 12 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">106658</p> <span class="spec-data">Twist Alliance Ancient Human DNA Panel - 13 Mb, 96 Reaktionen</span> </div> <div class="spec clearfix"> <p class="spec-label">104562</p> <span class="spec-data">Twist High Concentration Mitochondrial Panel, 96 Reaktionen</span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article></div> </div> </div> </div> </div> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--html paragraph--view-mode--default"> <div style="background-color:transparent"> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><style type="text/css">.system-picker-for-tabs, .field--name-field-cp-title, .system-sticky-tabs {display:none !important;} .field--name-field-pc-tabs::before {display:none !important;} .field--name-field-cp-paragraphs {padding-top: 0px !important;} .field--type-text-long ul li, .field--type-text-long ol li {font-size: 14px !important; line-height: 28px !important;} .paragraph--type--component-callout {margin-bottom:0 !important;} .desktop-layer .virtual-region-left .field--name-field-cp-text-text > 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