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Pancreatic mucinous cystic neoplasm - Wikipedia

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<div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><p class="mw-empty-elt"> </p> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Pancreatic mucinous cystic neoplasm</th></tr><tr><th scope="row" class="infobox-label">Other names</th><td class="infobox-data">MCN</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Gastroenterology" title="Gastroenterology">Gastroenterology</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Complication_(medicine)" title="Complication (medicine)">Complications</a></th><td class="infobox-data">Pancreatic cancer</td></tr><tr><th scope="row" class="infobox-label">Usual onset</th><td class="infobox-data">40-60 years of age</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Risk_factor" title="Risk factor">Risk factors</a></th><td class="infobox-data">Female gender, older age</td></tr><tr><th scope="row" class="infobox-label">Treatment</th><td class="infobox-data">Surgical resection</td></tr></tbody></table> <p><b>Pancreatic mucinous cystic neoplasm</b> (<b>MCN</b>) is a type of cystic lesion that occurs in the <a href="/wiki/Pancreas" title="Pancreas">pancreas</a>. Amongst individuals undergoing surgical resection of a pancreatic cyst, about 23 percent were <a href="/wiki/Mucinous_cystic_neoplasm" title="Mucinous cystic neoplasm">mucinous cystic neoplasms</a>. These lesions are benign, though there is a high rate of progression to <a href="/wiki/Cancer" title="Cancer">cancer</a>. As such, surgery should be pursued when feasible. The rate of malignancy present in MCN is about 10 percent.<sup id="cite_ref-Elta_1-0" class="reference"><a href="#cite_note-Elta-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> If resection is performed before invasive malignancy develops, prognosis is excellent. The extent of invasion is the single most important prognostic factor in predicting survival.<sup id="cite_ref-Zamboni_2-0" class="reference"><a href="#cite_note-Zamboni-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Pathology">Pathology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Pancreatic_mucinous_cystic_neoplasm&amp;action=edit&amp;section=1" title="Edit section: Pathology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Histologic evaluation of MCNs shows mucin-producing columnar epithelial lining, which is surrounded by ovarian-like stroma.<sup id="cite_ref-Elta_1-1" class="reference"><a href="#cite_note-Elta-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Calcification may be present. Factors that predict malignancy include loculated appearance, mural nodules, papillary projections, p53 immunoreactivity, and loss of ovarian-like stroma.<sup id="cite_ref-Zamboni_2-1" class="reference"><a href="#cite_note-Zamboni-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Pancreatic_mucinous_cystic_neoplasm&amp;action=edit&amp;section=2" title="Edit section: Diagnosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The diagnosis of pancreatic MCN is typically achieved with imaging. If the results of imaging (CT/MRI) are unclear, then endoscopic ultrasound with fine needle aspiration (EUS-FNA) of the cyst may be necessary.<sup id="cite_ref-Elta_1-2" class="reference"><a href="#cite_note-Elta-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Cyst fluid analysis may help distinguish potentially premalignant mucinous cysts (MCNs and IPMNs), from benign non-mucinous cysts.<sup id="cite_ref-Elta_1-3" class="reference"><a href="#cite_note-Elta-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> However, cyst fluid analysis cannot rule out the presence of pancreatic cancer or high grade dysplasia.<sup id="cite_ref-Elta_1-4" class="reference"><a href="#cite_note-Elta-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Management">Management</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Pancreatic_mucinous_cystic_neoplasm&amp;action=edit&amp;section=3" title="Edit section: Management"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Where possible, surgical resection of mucinous cystic neoplasms is preferable. In individuals who are eligible to undergo surgery, who are found to have asymptomatic cysts that appear to be benign MCNs or IPMNs, then surveillance imaging may be considered.<sup id="cite_ref-Elta_1-5" class="reference"><a href="#cite_note-Elta-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> </p><p>Following surgery, if resected tissue consists only of MCN without cancer, then further postoperative surveillance imaging is not necessary.<sup id="cite_ref-Elta_1-6" class="reference"><a href="#cite_note-Elta-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> </p><p>In individuals unable to undergo surgery, there may be a role for <a href="/wiki/Endoscopic_ultrasound" title="Endoscopic ultrasound">endoscopic ultrasound</a> (EUS) guided ablation with alcohol lavage with <a href="/wiki/Paclitaxel" title="Paclitaxel">paclitaxel</a> injection. EUS guided therapy has been performed successfully, though more data is necessary, particularly prospective study.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> An EUS-guided approach appears more effective with smaller sized MCNs.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Epidemiology">Epidemiology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Pancreatic_mucinous_cystic_neoplasm&amp;action=edit&amp;section=4" title="Edit section: Epidemiology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Relative_incidence_of_pancreatic_neoplasms.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/95/Relative_incidence_of_pancreatic_neoplasms.png/350px-Relative_incidence_of_pancreatic_neoplasms.png" decoding="async" width="350" height="180" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/95/Relative_incidence_of_pancreatic_neoplasms.png/525px-Relative_incidence_of_pancreatic_neoplasms.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/95/Relative_incidence_of_pancreatic_neoplasms.png/700px-Relative_incidence_of_pancreatic_neoplasms.png 2x" data-file-width="1270" data-file-height="653" /></a><figcaption>Relative incidences of various pancreatic neoplasms, with mucinous cystic neoplasm annotated near bottom right.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup></figcaption></figure> <p>MCNs are much more common in women.<sup id="cite_ref-Reddy_7-0" class="reference"><a href="#cite_note-Reddy-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup> A study in 2012 found that amongst individuals undergoing surgical resection of a pancreatic cyst, about 23 percent were mucinous cystic neoplasms.<sup id="cite_ref-Valsangkar_8-0" class="reference"><a href="#cite_note-Valsangkar-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup> The rate of malignancy present in MCN is about 10 percent.<sup id="cite_ref-Elta_1-7" class="reference"><a href="#cite_note-Elta-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Malignancy is more often present in older individuals.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Pancreatic_mucinous_cystic_neoplasm&amp;action=edit&amp;section=5" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Intraductal_papillary_mucinous_neoplasm" title="Intraductal papillary mucinous neoplasm">Intraductal papillary mucinous neoplasm</a></li> <li><a href="/wiki/Pancreatic_serous_cystadenoma" title="Pancreatic serous cystadenoma">Pancreatic serous cystadenoma</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Pancreatic_mucinous_cystic_neoplasm&amp;action=edit&amp;section=6" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output 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rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFValsangkarMorales-OyarvideThayerFerrone2012" class="citation journal cs1">Valsangkar, NP; Morales-Oyarvide, V; Thayer, SP; Ferrone, CR; Wargo, JA; Warshaw, AL; Fernández-del Castillo, C (September 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806101">"851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital"</a>. <i>Surgery</i>. <b>152</b> (3 Suppl 1): S4-12. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.surg.2012.05.033">10.1016/j.surg.2012.05.033</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806101">3806101</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22770958">22770958</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Surgery&amp;rft.atitle=851+resected+cystic+tumors+of+the+pancreas%3A+a+33-year+experience+at+the+Massachusetts+General+Hospital.&amp;rft.volume=152&amp;rft.issue=3+Suppl+1&amp;rft.pages=S4-12&amp;rft.date=2012-09&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3806101%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F22770958&amp;rft_id=info%3Adoi%2F10.1016%2Fj.surg.2012.05.033&amp;rft.aulast=Valsangkar&amp;rft.aufirst=NP&amp;rft.au=Morales-Oyarvide%2C+V&amp;rft.au=Thayer%2C+SP&amp;rft.au=Ferrone%2C+CR&amp;rft.au=Wargo%2C+JA&amp;rft.au=Warshaw%2C+AL&amp;rft.au=Fern%C3%A1ndez-del+Castillo%2C+C&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3806101&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3APancreatic+mucinous+cystic+neoplasm" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCrippaSalviaWarshawDomínguez2008" class="citation journal cs1">Crippa, Stefano; Salvia, Roberto; Warshaw, Andrew L.; Domínguez, Ismael; Bassi, Claudio; Falconi, Massimo; Thayer, Sarah P.; Zamboni, Giuseppe; Lauwers, Gregory Y.; Mino-Kenudson, Mari; Capelli, Paola; Pederzoli, Paolo; Castillo, Carlos Fernández-del (April 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806104">"Mucinous Cystic Neoplasm of the Pancreas is Not an Aggressive Entity"</a>. <i>Annals of Surgery</i>. <b>247</b> (4): 571–579. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FSLA.0b013e31811f4449">10.1097/SLA.0b013e31811f4449</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806104">3806104</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18362619">18362619</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Annals+of+Surgery&amp;rft.atitle=Mucinous+Cystic+Neoplasm+of+the+Pancreas+is+Not+an+Aggressive+Entity&amp;rft.volume=247&amp;rft.issue=4&amp;rft.pages=571-579&amp;rft.date=2008-04&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3806104%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F18362619&amp;rft_id=info%3Adoi%2F10.1097%2FSLA.0b013e31811f4449&amp;rft.aulast=Crippa&amp;rft.aufirst=Stefano&amp;rft.au=Salvia%2C+Roberto&amp;rft.au=Warshaw%2C+Andrew+L.&amp;rft.au=Dom%C3%ADnguez%2C+Ismael&amp;rft.au=Bassi%2C+Claudio&amp;rft.au=Falconi%2C+Massimo&amp;rft.au=Thayer%2C+Sarah+P.&amp;rft.au=Zamboni%2C+Giuseppe&amp;rft.au=Lauwers%2C+Gregory+Y.&amp;rft.au=Mino-Kenudson%2C+Mari&amp;rft.au=Capelli%2C+Paola&amp;rft.au=Pederzoli%2C+Paolo&amp;rft.au=Castillo%2C+Carlos+Fern%C3%A1ndez-del&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3806104&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3APancreatic+mucinous+cystic+neoplasm" 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neoplasm">Digestive system neoplasia</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Human_gastrointestinal_tract" class="mw-redirect" title="Human gastrointestinal tract">GI tract</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Upper_alimentary_tract#Upper_gastrointestinal_tract" class="mw-redirect" title="Upper alimentary tract">Upper</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Esophageal_cancer" title="Esophageal cancer">Esophagus</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Squamous_cell_carcinoma" class="mw-redirect" title="Squamous cell carcinoma">Squamous cell carcinoma</a></li> <li><a href="/wiki/Adenocarcinoma" title="Adenocarcinoma">Adenocarcinoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Stomach_cancer" title="Stomach cancer">Stomach</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Gastric_carcinoma" class="mw-redirect" title="Gastric carcinoma">Gastric carcinoma</a></li> <li><a href="/wiki/Signet_ring_cell_carcinoma" title="Signet ring cell carcinoma">Signet ring cell carcinoma</a></li> <li><a href="/wiki/Gastric_lymphoma" title="Gastric lymphoma">Gastric lymphoma</a> <ul><li><a href="/wiki/MALT_lymphoma" title="MALT lymphoma">MALT lymphoma</a></li></ul></li> <li><a href="/wiki/Linitis_plastica" title="Linitis plastica">Linitis plastica</a></li> <li><a href="/wiki/Hereditary_diffuse_gastric_cancer" title="Hereditary diffuse gastric cancer">Hereditary diffuse gastric cancer</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Human_gastrointestinal_tract#Lower_gastrointestinal_tract" class="mw-redirect" title="Human gastrointestinal tract">Lower</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Small_intestine_cancer" title="Small intestine cancer">Small intestine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Duodenal_cancer" title="Duodenal cancer">Duodenal cancer</a> <ul><li><a href="/wiki/Adenocarcinoma" title="Adenocarcinoma">Adenocarcinoma</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Appendix_cancer" title="Appendix cancer">Appendix</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carcinoid" title="Carcinoid">Carcinoid</a></li> <li><a href="/wiki/Pseudomyxoma_peritonei" title="Pseudomyxoma peritonei">Pseudomyxoma peritonei</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Colorectal_cancer" title="Colorectal cancer">Colon/rectum</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Colorectal_polyp" title="Colorectal polyp">Colorectal polyp</a>:</i> <a href="/wiki/Colorectal_adenoma" title="Colorectal adenoma">adenoma</a>, <a href="/wiki/Hyperplastic_polyp" title="Hyperplastic polyp">hyperplastic</a>, <a href="/wiki/Juvenile_polyp" title="Juvenile polyp">juvenile</a>, <a href="/wiki/Sessile_serrated_adenoma" class="mw-redirect" title="Sessile serrated adenoma">sessile serrated adenoma</a>, <a href="/wiki/Traditional_serrated_adenoma" title="Traditional serrated adenoma">traditional serrated adenoma</a>, <a href="/wiki/Peutz%E2%80%93Jeghers_syndrome" title="Peutz–Jeghers syndrome">Peutz–Jeghers</a>, <a href="/wiki/Cronkhite%E2%80%93Canada_syndrome" title="Cronkhite–Canada syndrome">Cronkhite–Canada</a></li></ul> <ul><li><i>Polyposis syndromes:</i> <a href="/wiki/Juvenile_polyposis_syndrome" title="Juvenile polyposis syndrome">Juvenile</a></li> <li><a href="/wiki/MUTYH-associated_polyposis" title="MUTYH-associated polyposis">MUTYH-associated</a></li> <li><a href="/wiki/Familial_adenomatous_polyposis" title="Familial adenomatous polyposis">Familial adenomatous</a>/<a href="/wiki/Gardner%27s_syndrome" title="Gardner&#39;s syndrome">Gardner's</a></li> <li><a href="/wiki/Polymerase_proofreading-associated_polyposis" title="Polymerase proofreading-associated polyposis">Polymerase proofreading-associated</a></li> <li><a href="/wiki/Serrated_polyposis_syndrome" title="Serrated polyposis syndrome">Serrated polyposis</a></li></ul> <ul><li><i>Neoplasm:</i> <a href="/wiki/Adenocarcinoma" title="Adenocarcinoma">Adenocarcinoma</a></li> <li><a href="/wiki/Familial_adenomatous_polyposis" title="Familial adenomatous polyposis">Familial adenomatous polyposis</a></li> <li><a href="/wiki/Hereditary_nonpolyposis_colorectal_cancer" title="Hereditary nonpolyposis colorectal cancer">Hereditary nonpolyposis colorectal cancer</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Anal_cancer" title="Anal cancer">Anus</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Squamous_cell_carcinoma" class="mw-redirect" title="Squamous cell carcinoma">Squamous cell carcinoma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Upper and/or lower</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Gastrointestinal_stromal_tumor" title="Gastrointestinal stromal tumor">Gastrointestinal stromal tumor</a></li> <li><a href="/wiki/Krukenberg_tumor" title="Krukenberg tumor">Krukenberg tumor (metastatic)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Accessory_digestive_gland" class="mw-redirect" title="Accessory digestive gland">Accessory</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Liver_tumor" title="Liver tumor">Liver</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Malignant" class="mw-redirect" title="Malignant">malignant</a>:</i> <a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">Hepatocellular carcinoma</a> <ul><li><a href="/wiki/Fibrolamellar_hepatocellular_carcinoma" title="Fibrolamellar hepatocellular carcinoma">Fibrolamellar</a></li></ul></li> <li><a href="/wiki/Hepatoblastoma" title="Hepatoblastoma">Hepatoblastoma</a></li> <li><a href="/wiki/Liver_angiosarcoma" title="Liver angiosarcoma">Liver angiosarcoma</a></li></ul> <ul><li><i><a href="/wiki/Benign_tumor" title="Benign tumor">benign</a>:</i> <a href="/wiki/Hepatocellular_adenoma" title="Hepatocellular adenoma">Hepatocellular adenoma</a></li> <li><a href="/wiki/Cavernous_hemangioma" title="Cavernous hemangioma">Cavernous hemangioma</a></li></ul> <ul><li><i><a href="/wiki/Hyperplasia" title="Hyperplasia">hyperplasia</a>:</i> <a href="/wiki/Focal_nodular_hyperplasia" title="Focal nodular hyperplasia">Focal nodular hyperplasia</a></li> <li><a href="/wiki/Nodular_regenerative_hyperplasia" title="Nodular regenerative hyperplasia">Nodular regenerative hyperplasia</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Biliary_tract" title="Biliary tract">Biliary tract</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Bile_duct" title="Bile duct">bile duct</a>:</i> <a href="/wiki/Cholangiocarcinoma" title="Cholangiocarcinoma">Cholangiocarcinoma</a></li> <li><a href="/wiki/Klatskin_tumor" title="Klatskin tumor">Klatskin tumor</a></li></ul> <ul><li><i><a href="/wiki/Gallbladder" title="Gallbladder">gallbladder</a>:</i> <a href="/wiki/Gallbladder_cancer" title="Gallbladder cancer">Gallbladder cancer</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pancreatic_cancer" title="Pancreatic cancer">Pancreas</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Exocrine_pancreas" class="mw-redirect" title="Exocrine pancreas">exocrine pancreas</a>:</i> <a href="/wiki/Adenocarcinoma" title="Adenocarcinoma">Adenocarcinoma</a></li> <li><a href="/wiki/Pancreatic_ductal_carcinoma" class="mw-redirect" title="Pancreatic ductal carcinoma">Pancreatic ductal carcinoma</a></li></ul> <ul><li><i><a href="/wiki/Cyst" title="Cyst">cystic</a> <a href="/wiki/Neoplasm" title="Neoplasm">neoplasms</a></i>: <a href="/wiki/Serous_microcystic_adenoma" class="mw-redirect" title="Serous microcystic adenoma">Serous microcystic adenoma</a></li> <li><a href="/wiki/Intraductal_papillary_mucinous_neoplasm" title="Intraductal papillary mucinous neoplasm">Intraductal papillary mucinous neoplasm</a></li> <li><a class="mw-selflink selflink">Mucinous cystic neoplasm</a></li> <li><a href="/wiki/Solid_pseudopapillary_neoplasm" class="mw-redirect" title="Solid pseudopapillary neoplasm">Solid pseudopapillary neoplasm</a></li></ul> <ul><li><a href="/wiki/Pancreatoblastoma" title="Pancreatoblastoma">Pancreatoblastoma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Peritoneum" title="Peritoneum">Peritoneum</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Primary_peritoneal_carcinoma" title="Primary peritoneal carcinoma">Primary peritoneal carcinoma</a></li> <li><a href="/wiki/Peritoneal_mesothelioma" title="Peritoneal mesothelioma">Peritoneal mesothelioma</a></li> <li><a href="/wiki/Desmoplastic_small_round_cell_tumor" class="mw-redirect" title="Desmoplastic small round cell tumor">Desmoplastic small round cell tumor</a></li></ul> </div></td></tr></tbody></table></div> <!-- NewPP limit report Parsed by mw‐web.eqiad.main‐5dc468848‐c55jm Cached time: 20241122153825 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 0.385 seconds Real time usage: 0.578 seconds Preprocessor visited node count: 1538/1000000 Post‐expand include size: 67528/2097152 bytes Template argument size: 991/2097152 bytes Highest expansion depth: 12/100 Expensive parser function count: 2/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 49101/5000000 bytes Lua time usage: 0.259/10.000 seconds Lua memory usage: 6129076/52428800 bytes Number of Wikibase entities loaded: 0/400 --> <!-- Transclusion expansion time report (%,ms,calls,template) 100.00% 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