AGG Interruption Testing | Xpansion Interpreter®

<!DOCTYPE html> <html lang="en-US"> <head> <meta charset="UTF-8" /> <title> AGG Interruption Testing | Xpansion Interpreter® | Asuragen </title> <meta name="description" content="Discover Asuragen's Xpansion Interpreter - Simplify the analysis of repeat expansions with advanced algorithms and comprehensive variant interpretation."> <meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=1"> <meta http-equiv="X-UA-TextLayoutMetrics" content="gdi" /> <link rel="preload" href="https://asuragen.com/wp-content/themes/nmc_asuragen/css/fonts/Avenir-400.woff2" as="font" type="font/woff2" crossorigin="anonymous"> <link rel="preload" href="https://asuragen.com/wp-content/themes/nmc_asuragen/css/fonts/Avenir-600.woff2" as="font" type="font/woff2" crossorigin="anonymous"> <link rel="preload" href="https://asuragen.com/wp-content/themes/nmc_asuragen/css/fonts/Avenir-700.woff2" as="font" type="font/woff2" crossorigin="anonymous"> <style> @font-face { font-family: 'Avenir'; src: url(https://asuragen.com/wp-content/themes/nmc_asuragen/css/fonts/Avenir-400.woff2); font-weight: 400; font-style: normal; font-display: fallback; } @font-face { font-family: 'Avenir'; src: url(https://asuragen.com/wp-content/themes/nmc_asuragen/css/fonts/Avenir-600.woff2); font-weight: 600; font-style: normal; font-display: fallback; } @font-face { font-family: 'Avenir'; src: url(https://asuragen.com/wp-content/themes/nmc_asuragen/css/fonts/Avenir-700.woff2); font-weight: 700; font-style: normal; font-display: fallback; } </style> <link rel='stylesheet' id='all-css' href='https://asuragen.com/wp-content/themes/nmc_asuragen/css/all.min.css?ver=1721665082' type='text/css' media='all' /> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' /> <style>img:is([sizes="auto" i], [sizes^="auto," i]) { contain-intrinsic-size: 3000px 1500px }</style>  <script data-cfasync="false" data-pagespeed-no-defer> var gtm4wp_datalayer_name = "dataLayer"; var dataLayer = dataLayer || []; </script>   <meta name="description" content="Discover Asuragen's Xpansion Interpreter - Simplify the analysis of repeat expansions with advanced algorithms and comprehensive variant interpretation." /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="article" /> <meta property="og:title" content="AGG Interruption Testing | Xpansion Interpreter®" /> <meta property="og:description" content="Discover Asuragen's Xpansion Interpreter - Simplify the analysis of repeat expansions with advanced algorithms and comprehensive variant interpretation." /> <meta property="og:site_name" content="Asuragen" /> <meta property="article:publisher" content="https://www.facebook.com/Asuragen/" /> <meta property="article:modified_time" content="2024-03-25T17:05:41+00:00" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@Asuragen" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebPage","@id":"https://asuragen.com/portfolio/genetics/xpansion-interpreter/","url":"https://asuragen.com/portfolio/genetics/xpansion-interpreter/","name":"AGG Interruption Testing | Xpansion Interpreter®","isPartOf":{"@id":"https://asuragen.com/#website"},"datePublished":"2020-07-19T20:13:05+00:00","dateModified":"2024-03-25T17:05:41+00:00","description":"Discover Asuragen's Xpansion Interpreter - Simplify the analysis of repeat expansions with advanced algorithms and comprehensive variant interpretation.","breadcrumb":{"@id":"https://asuragen.com/portfolio/genetics/xpansion-interpreter/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https://asuragen.com/portfolio/genetics/xpansion-interpreter/"]}]},{"@type":"BreadcrumbList","@id":"https://asuragen.com/portfolio/genetics/xpansion-interpreter/#breadcrumb","itemListElement":[{"@type":"ListItem","position":"1","name":"Home","item":"https://asuragen.com/"},{"@type":"ListItem","position":"2","name":"Portfolio","item":"https://asuragen.com/portfolio/"},{"@type":"ListItem","position":"3","name":"Kitted Assays for Inherited Genetic Disorders","item":"https://asuragen.com/portfolio/genetics/"},{"@type":"ListItem","position":"4","name":"AGG Interruption Testing Service"}]},{"@type":"WebSite","@id":"https://asuragen.com/#website","url":"https://asuragen.com/","name":"Asuragen","description":"Asuragen is a global diagnostic products company delivering genetics and oncology products that address unmet needs for clinical research and laboratories.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://asuragen.com/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":"1","valueName":"search_term_string"}}],"inLanguage":"en-US"}]}</script>  <link rel='dns-prefetch' href='//asuragen.com' /> <link href='https://sp-ao.shortpixel.ai' rel='preconnect' /> <link rel="alternate" type="application/rss+xml" title="Asuragen » Feed" href="https://asuragen.com/feed/" /> <link rel="alternate" type="application/rss+xml" title="Asuragen » Comments Feed" href="https://asuragen.com/comments/feed/" /> <link rel='stylesheet' id='formidable-css' href='https://asuragen.com/wp-content/cache/autoptimize/css/autoptimize_single_c149d9e5c4674fbf3e1e4ba524dbaec6.css?ver=1221318' type='text/css' media='all' /> <link rel='stylesheet' id='wp-block-library-css' href='https://asuragen.com/wp-includes/css/dist/block-library/style.min.css?ver=6.7.2' type='text/css' media='all' /> <style id='classic-theme-styles-inline-css' type='text/css'> /*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--color--black: #000000;--wp--preset--color--cyan-bluish-gray: #abb8c3;--wp--preset--color--white: #ffffff;--wp--preset--color--pale-pink: #f78da7;--wp--preset--color--vivid-red: #cf2e2e;--wp--preset--color--luminous-vivid-orange: #ff6900;--wp--preset--color--luminous-vivid-amber: #fcb900;--wp--preset--color--light-green-cyan: #7bdcb5;--wp--preset--color--vivid-green-cyan: #00d084;--wp--preset--color--pale-cyan-blue: #8ed1fc;--wp--preset--color--vivid-cyan-blue: #0693e3;--wp--preset--color--vivid-purple: #9b51e0;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}:where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;}:where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;}.has-black-color{color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-color{color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-color{color: var(--wp--preset--color--white) !important;}.has-pale-pink-color{color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-color{color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-color{color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-color{color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-color{color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-color{color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-color{color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-color{color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-color{color: var(--wp--preset--color--vivid-purple) !important;}.has-black-background-color{background-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-background-color{background-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.has-pale-pink-background-color{background-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-background-color{background-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-background-color{background-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-background-color{background-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-background-color{background-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-background-color{background-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-background-color{background-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-background-color{background-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-background-color{background-color: var(--wp--preset--color--vivid-purple) !important;}.has-black-border-color{border-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-border-color{border-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.has-pale-pink-border-color{border-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-border-color{border-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-border-color{border-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-border-color{border-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-border-color{border-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-border-color{border-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-border-color{border-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-border-color{border-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-border-color{border-color: var(--wp--preset--color--vivid-purple) !important;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: 1.5em;line-height: 1.6;} </style> <link rel='stylesheet' id='custom-css' href='https://asuragen.com/wp-content/cache/autoptimize/css/autoptimize_single_a78d2feb9b01b90c66ea8cc8f423e2f9.css?ver=6.7.2' type='text/css' media='all' /> <link rel='stylesheet' id='tablepress-default-css' href='https://asuragen.com/wp-content/cache/autoptimize/css/autoptimize_single_9bae56f46cb8d01d16bc7087bd985c35.css?ver=3.0.3' type='text/css' media='all' /> <link rel="https://api.w.org/" href="https://asuragen.com/wp-json/" /><link rel="alternate" title="JSON" type="application/json" href="https://asuragen.com/wp-json/wp/v2/pages/192208" /><link rel="EditURI" type="application/rsd+xml" title="RSD" href="https://asuragen.com/xmlrpc.php?rsd" /> <meta name="generator" content="WordPress 6.7.2" /> <link rel='shortlink' href='https://asuragen.com/?p=192208' /> <link rel="alternate" title="oEmbed (JSON)" type="application/json+oembed" href="https://asuragen.com/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fasuragen.com%2Fportfolio%2Fgenetics%2Fxpansion-interpreter%2F" /> <link rel="alternate" title="oEmbed (XML)" type="text/xml+oembed" href="https://asuragen.com/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fasuragen.com%2Fportfolio%2Fgenetics%2Fxpansion-interpreter%2F&format=xml" /> <script>document.documentElement.className += " js";</script>   <script data-cfasync="false" data-pagespeed-no-defer type="text/javascript"> var dataLayer_content = {"pagePostType":"page","pagePostType2":"single-page","pagePostAuthor":"John McNamara"}; dataLayer.push( dataLayer_content ); </script> <script data-cfasync="false"> (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= '//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-NCKKMV8'); </script> <link rel="icon" href="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_32,h_32/https://asuragen.com/wp-content/uploads/2023/11/cropped-MicrosoftTeams-image-40-32x32.png" sizes="32x32" /> <link rel="icon" href="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_192,h_192/https://asuragen.com/wp-content/uploads/2023/11/cropped-MicrosoftTeams-image-40-192x192.png" sizes="192x192" /> <link rel="apple-touch-icon" href="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_180,h_180/https://asuragen.com/wp-content/uploads/2023/11/cropped-MicrosoftTeams-image-40-180x180.png" /> <meta name="msapplication-TileImage" content="https://asuragen.com/wp-content/uploads/2023/11/cropped-MicrosoftTeams-image-40-270x270.png" /> <link rel="shortcut icon" href="https://asuragen.com/wp-content/themes/nmc_asuragen/favicon.png"> <link rel="canonical" href="https://asuragen.com/portfolio/genetics/xpansion-interpreter/"> <meta name="og:url" content="https://asuragen.com/portfolio/genetics/xpansion-interpreter/"> <script> var _hmt = _hmt || []; (function() { var hm = document.createElement("script"); hm.src = "https://hm.baidu.com/hm.js?10e91b4ae89f4239ddc1a1e114003029"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); </script> </head> <body class="page-template page-template-template-solutions-detail page-template-template-solutions-detail-php page page-id-192208 page-child parent-pageid-242 bright-blue"> <header id="header"> <div class="bound-header"> <h1 id="logo"> <a href="https://asuragen.com"><svg xmlns="http://www.w3.org/2000/svg" fill-rule="evenodd" stroke-linejoin="round" stroke-miterlimit="2" clip-rule="evenodd" viewBox="0 0 400 210"><path fill="#525860" fill-rule="nonzero" d="M175.7 99.3a19.5 19.5 0 0 0-6.4 4.6v-5.5H159v47.4h10.3v-21.1c0-4.5 1.3-8.5 3.8-11.7a12 12 0 0 1 10-5h2.7V97.7h-2.3c-3 0-5.6.5-7.8 1.6zm208.4 4a17 17 0 0 0-6.2-4c-2.3-1-5-1.4-8.1-1.4a16 16 0 0 0-8.8 2.5 25 25 0 0 0-2.9 2.1v-3.9h-10.3V146h10.3v-27a10.9 10.9 0 0 1 11.3-11.4c3 0 5.5 1 7.4 3 2 2 3 4.8 3 8.3V146H390v-27.3c0-6.3-2-11.4-5.9-15.3zm-244 22.3A10.9 10.9 0 0 1 129 137c-3.1 0-5.6-1-7.5-3-1.9-2-2.9-4.8-2.9-8.3v-27h-10.3v27.2c0 6.3 2 11.5 6 15.3a17.1 17.1 0 0 0 6.1 4.1c2.3 1 5 1.4 8.2 1.4a16 16 0 0 0 8.8-2.5c1-.6 2-1.3 2.8-2.1v3.9h10.4V98.6H140v27zm-99.7-6.1H22.5l9-21.4 8.9 21.4zm-3.6-35H26.1L0 146h11.3l7.1-16.7h26.1l7 16.7H63L37 85l-.2-.5zm57.5 35.3c-2.2-1-4.7-1.6-7.4-2.2A101.2 101.2 0 0 1 80 116c-2-.5-3.5-1.2-4.8-2-.9-.5-1.3-1.2-1.3-2.3 0-1.2 0-4.4 8.2-4.4 7 0 8.6 2.5 9 4.6l9.8-3a14.2 14.2 0 0 0-4.5-6.7 21 21 0 0 0-13.8-4.3c-6 0-10.7 1.3-14 3.7-3.3 2.5-5 6.1-5 10.7 0 3.1 1 5.7 2.7 7.6a17 17 0 0 0 6 4 40 40 0 0 0 7.4 2.1 89 89 0 0 1 6.8 1.7c2 .5 3.6 1.2 4.9 2a3 3 0 0 1 1.3 2.6c0 2-1 3.1-3 4-1 .4-2.2.6-3.3.8a18 18 0 0 1-7.8-.4c-3-1-4.7-2.8-5.3-5.5l-8.8 6.3a15.2 15.2 0 0 0 3.7 4.4c3.8 3.2 8.9 4.8 15 4.8a24 24 0 0 0 14.2-3.7 13 13 0 0 0 5.6-11.3c0-3.2-1-5.8-2.7-7.7a16.9 16.9 0 0 0-6-4.2zm214.2-8.9c2.4-2.2 5.2-3.3 8.8-3.3a12.5 12.5 0 0 1 12.5 9.3h-25a13 13 0 0 1 3.7-6zm18.5 22.4a11.6 11.6 0 0 1-9.2 3.7c-3.8 0-6.9-1.1-9.3-3.5-2-1.8-3.2-4-3.8-6.7h36.1v-4.5c0-6.9-2.1-12.7-6.3-17.2a22.6 22.6 0 0 0-17.2-7.2c-7 0-12.8 2.4-17.3 7.2a24.7 24.7 0 0 0-6.2 17.2c0 6.9 2.2 12.7 6.5 17.3a23 23 0 0 0 17.4 7.1 23 23 0 0 0 13.8-4c1.4-1 2.5-2.1 3.6-3.4l-8-6zm-63.4 2.6a13.9 13.9 0 1 1 0-27.8 13.9 13.9 0 0 1 0 27.8zm13-37.3v4c-3.5-3.1-8-4.7-13.2-4.7-7.1 0-13 2.4-17.2 7.1a24.2 24.2 0 0 0-6.3 17c0 6.7 2.1 12.4 6.3 17 4.3 4.6 10 7 16.7 7 5.5 0 10.1-1.6 13.7-4.7v1c0 4-1 7-2.8 9-2 2-5.2 3-9.7 3-5.7 0-9.3-1.8-10.9-5.5l-8.4 6c1.3 2 3 3.9 5.2 5.3 3.7 2.6 8.9 3.9 15.3 3.9 6.5 0 11.7-1.9 15.7-5.5s6-8.9 6-15.7V98.6h-10.4zM210.5 136a13.9 13.9 0 1 1 0-27.8 13.9 13.9 0 0 1 0 27.8zm13-37.3v4c-3.5-3.1-8-4.7-13.2-4.7a22 22 0 0 0-17.2 7.2 25 25 0 0 0-6.3 17.2 25 25 0 0 0 6.3 17.2c4.3 4.8 10 7.2 16.7 7.2 5.5 0 10.2-1.6 13.7-4.6v3.9H234V98.6h-10.4z" class="asuragen"/><path fill="#ee6d20" fill-rule="nonzero" d="M195 0a108 108 0 0 0-45.5 9.1 87.4 87.4 0 0 0-20.4 13.7 72.5 72.5 0 0 0 29.3 34A170 170 0 0 1 195 24.1c13-7.9 28.6-13 45.5-15A110 110 0 0 0 195 0z"/><path fill="#005f9f" fill-rule="nonzero" d="m246.2 12.2-5.3.6a110.7 110.7 0 0 0-42.4 13.6 247 247 0 0 1 33.9 29.8A71.7 71.7 0 0 0 261 22.7a99 99 0 0 0-14.8-10.5zM19.7 192.5l-3.8-.2c-3.2 0-5.7.6-7.5 1.6a5.1 5.1 0 0 0-2.7 4.7c0 1.3.5 2.4 1.5 3.3 1 1 2.3 1.4 4.1 1.4 2.5 0 4.5-1 6-2.7a9 9 0 0 0 2.5-6.4l-.1-1.7zm4.5 13.2h-4c-.2-.8-.4-2.4-.5-4.7a9.6 9.6 0 0 1-9.2 5.5c-3 0-5.2-.8-6.8-2.4a7.7 7.7 0 0 1-2.3-5.7 8 8 0 0 1 3.4-6.6c2.2-1.7 6-2.6 11.4-2.6l3.5.1c0-2-.2-3.6-.5-4.5a4 4 0 0 0-2-2.3c-1-.5-2.4-.8-4.1-.8-4.2 0-6.6 1.6-7.2 4.8l-3.8-.7c1-4.9 4.8-7.3 11.6-7.3 3.6 0 6.1.8 7.6 2.4 1.6 1.7 2.3 4.5 2.3 8.4v11.3c0 1.9.2 3.6.6 5.1zm282.3 0h-4v-26.4h3.5v6.2c1.3-3 2.5-4.8 3.8-5.7a6.9 6.9 0 0 1 3.9-1.3l1.6.1v4h-.8c-2.3 0-4.1.8-5.6 2.5s-2.3 3.9-2.4 6.7v14zm28-13.2-3.8-.1c-3.2 0-5.7.5-7.5 1.6a5.1 5.1 0 0 0-2.6 4.6c0 1.3.4 2.4 1.4 3.4s2.3 1.3 4.2 1.3c2.4 0 4.4-.9 6-2.7a9.2 9.2 0 0 0 2.4-6.3l-.1-1.8zm4.5 13.3h-4c-.2-.9-.3-2.5-.5-4.8-1.8 3.7-4.9 5.5-9.2 5.5-3 0-5.2-.8-6.7-2.4a7.7 7.7 0 0 1-2.4-5.6 8 8 0 0 1 3.4-6.6c2.2-1.8 6-2.6 11.4-2.6h3.5c0-2-.2-3.5-.5-4.5a4 4 0 0 0-2-2.2 8 8 0 0 0-4.1-.9c-4.1 0-6.5 1.6-7.2 4.8l-3.8-.6c1-5 4.8-7.3 11.6-7.3 3.6 0 6.2.8 7.7 2.4 1.5 1.6 2.2 4.4 2.2 8.4v11.2c0 1.9.2 3.6.6 5.2zm24 0h-3.8v-17c0-2.5-.6-4.2-1.6-5.2s-2.4-1.5-3.9-1.5c-2 0-3.8.8-5.2 2.5a10 10 0 0 0-2 6.6v14.6h-4.2v-26.5h3.8v4.9c2.1-3.8 4.9-5.6 8.3-5.6a8.2 8.2 0 0 1 7.8 4.9c.5 1.3.8 3.6.8 7v15.3zm22.4-16.3c0-2.3-.7-4.2-2.1-5.6a6.7 6.7 0 0 0-5-2 6 6 0 0 0-5 2.7 13 13 0 0 0-1.9 7.6c0 3.6.6 6.3 1.8 8.1a5.6 5.6 0 0 0 5 2.8c1.9 0 3.5-.8 5-2.4a8.2 8.2 0 0 0 2.2-5.7v-5.5zm4-19.5v35.8h-3.6v-4.6c-1.9 3.5-4.6 5.3-8.3 5.3a9 9 0 0 1-7.6-3.9c-2-2.6-3-5.9-3-9.9s1-7.4 3-10a9 9 0 0 1 7.8-4.1 9 9 0 0 1 7.7 4.3v-13h4zM50.1 193.9c0 2.5.5 4.3 1.6 5.5 1 1.2 2.4 1.7 4.1 1.7 1.7 0 3-.6 4.1-2 1.1-1.3 1.7-4 1.8-8 0-2.9-.5-5.1-1.5-6.7a4.7 4.7 0 0 0-4.2-2.3c-1.7 0-3.1.7-4.2 2a8.7 8.7 0 0 0-1.7 5.7v4zm0 11.8H44v-38.4h6.2v14.5a10 10 0 0 1 3.6-4.1 9 9 0 0 1 11.6 2.9c2 2.5 3 6.1 3 10.7 0 4.1-1 7.7-3 10.6-2 3-4.7 4.4-8.4 4.4-1.2 0-2.7-.2-4-.8-1.7-.8-2.8-2-2.8-2v2.2zm43.2-4.5c-2 0-3.5-.8-4.7-2.4A11.5 11.5 0 0 1 87 192c0-2.8.6-5 1.6-6.7 1.1-1.7 2.8-2.5 5-2.5s3.8.8 4.8 2.4c.6 1 1 2.2 1.3 3.6h-5.8L93 194h6.9c-.5 4.8-2.6 7.2-6.5 7.2zm19-12.4h-5.8a13 13 0 0 0-3.5-7.1c-2.4-2.6-5.6-4-9.5-4-4 0-7.3 1.4-9.7 4a14.6 14.6 0 0 0-3.7 10.2c0 3.8 1 7 3.3 10 2.2 3 5.5 4.4 9.7 4.4a13 13 0 0 0 13.5-12.3h5.8v-5.2z"/><path fill="#005f9f" fill-rule="nonzero" d="M127 200.8v4.9c-1.9.4-3.3.6-4.3.6-1.7 0-3.1-.3-4.3-1a6.6 6.6 0 0 1-2.7-2.8 14 14 0 0 1-.8-5.3v-14.4h-4.3v-4.9h4.7l.5-7.2 5.1-.5v7.7h5.5v4.9H121v13.5c0 1.8.3 3 1 3.6.6.6 1.8 1 3.5 1l1.6-.1zm45.3-5.3 5.3.5c-.7 3.5-2 6-4 7.8-2 1.6-4.4 2.5-7.2 2.5-3.7 0-6.7-1.4-8.7-4.2a17 17 0 0 1-3-10.3c0-4.2 1-7.6 3.3-10.4a11 11 0 0 1 9-4c5.9 0 9.4 3.1 10.6 9.5l-5.3.7c-.5-3.4-2.2-5.1-5-5.1-2.2 0-3.7.9-4.6 2.8-1 1.8-1.5 4-1.5 6.7 0 2.8.5 5 1.5 6.5s2.4 2.3 4.2 2.3c2.7 0 4.5-1.8 5.4-5.3zm30.5 10.2h-6.2v-18.1c0-2-.4-3.4-1.3-4.2a4 4 0 0 0-2.9-1.2c-1.7 0-3.2.7-4.4 2.1-1.2 1.5-1.8 3.8-1.8 7v14.4H180v-37.5h6.2v14.6c1.6-4 4.3-6 8.1-6 5.7 0 8.5 3.3 8.5 9.8v19.1zm26 0h-6.2v-17.3c0-1.9-.4-3.2-1.2-4.2a4 4 0 0 0-3-1.3c-1.7 0-3 .7-4.3 2.1-1.2 1.4-1.8 3.6-1.8 6.5v14.2H206V178h5.7v6.4c2-4.7 4.7-7 8.3-7a9 9 0 0 1 6.2 2.3c1.7 1.5 2.5 4.2 2.5 8.1v18zm8.8-17.2a8 8 0 0 1 2-5 5.7 5.7 0 0 1 4.2-1.8c1.8 0 3.2.7 4.4 2a7 7 0 0 1 1.8 4.8h-12.4zm18.8 3.3c0-4.2-1-7.7-3.2-10.4-2.1-2.7-5.1-4-9-4-4 0-7.2 1.3-9.6 4a15.5 15.5 0 0 0-3.5 10.5c0 4.4 1.2 7.9 3.5 10.5 2.3 2.6 5.4 3.9 9.2 3.9 3.2 0 5.8-.9 7.9-2.5 2.1-1.6 3.5-3.7 4.2-6.2l-5.6-.8c-1 3-3 4.5-6.2 4.5a6 6 0 0 1-6-4.2 14 14 0 0 1-.5-4.5h18.8v-.8zM71.1 180.7h6.2v25h-6.2zm6.4-5.8c0 1.8-1.5 3.3-3.3 3.3a3.3 3.3 0 0 1-3.2-3.3c0-1.8 1.4-3.3 3.2-3.3 1.8 0 3.3 1.5 3.3 3.3zm180.7 5.6h.4c.5 0 .9-.2.9-.7 0-.3-.2-.6-.9-.6h-.4v1.3zm0 2h-.6v-3.7h1c.6 0 1 0 1.2.2.2.2.3.4.3.8 0 .5-.3.7-.7.9.3 0 .5.3.6.9 0 .5.2.7.2.9h-.6l-.2-1c-.1-.4-.3-.6-.8-.6h-.4v1.6zm.6-4.7a2.7 2.7 0 0 0-2.7 2.8 2.7 2.7 0 0 0 2.7 2.7 2.7 2.7 0 0 0 2.8-2.7 2.7 2.7 0 0 0-2.8-2.8zm0-.5a3.2 3.2 0 0 1 3.2 3.3c0 1.8-1.4 3.2-3.2 3.2a3.2 3.2 0 0 1-3.3-3.2 3.2 3.2 0 0 1 3.3-3.3zm21.4 17.7c0 2.2.8 4 2.2 5.7a6.6 6.6 0 0 0 5 2.4c2.1 0 3.8-1 5-2.8a15 15 0 0 0 1.8-8 13 13 0 0 0-2-7.7 6 6 0 0 0-5-2.8c-1.8 0-3.5.7-4.9 2.1a7.5 7.5 0 0 0-2 5.6v5.5zm0-25v12.9a9 9 0 0 1 7.7-4.3 9 9 0 0 1 7.8 4c2 2.7 3 6 3 10.1 0 4-1 7.3-3 9.9a9 9 0 0 1-7.6 3.9c-3.7 0-6.4-1.8-8.3-5.3v4.6h-3.6V170h4zM134 188.5a8 8 0 0 1 2-5 5.7 5.7 0 0 1 4.3-1.8c1.7 0 3.2.7 4.4 2a7 7 0 0 1 1.7 4.8H134zm19 3.3c0-4.2-1.2-7.7-3.3-10.4-2.1-2.7-5.2-4-9-4a12 12 0 0 0-9.6 4 15.5 15.5 0 0 0-3.5 10.5c0 4.4 1.2 7.9 3.5 10.5 2.3 2.6 5.4 3.9 9.2 3.9 3.1 0 5.8-.9 7.9-2.5 2-1.6 3.5-3.7 4.2-6.2l-5.6-.8c-1 3-3.1 4.5-6.2 4.5a6 6 0 0 1-6-4.2c-.4-1.1-.6-2.6-.6-4.5h18.9v-.8z"/><path fill="#525860" fill-rule="nonzero" d="M395.4 102c.5 0 1.1-.2 1.1-.8 0-.5-.5-.7-1-.7h-.8v1.4h.7zm-1.6-2.3h1.7c1 0 1.9.4 1.9 1.5 0 .7-.4 1.2-1.2 1.4l1.4 2.2h-1.1l-1.2-2.1h-.6v2h-1v-5zm1.7 6.4a3.8 3.8 0 0 0 3.8-3.8 3.8 3.8 0 0 0-7.6 0 3.8 3.8 0 0 0 3.8 3.8zm0-8.3a4.5 4.5 0 0 1 4.5 4.5c0 2.5-2 4.4-4.5 4.4s-4.5-2-4.5-4.4a4.5 4.5 0 0 1 4.5-4.5z"/></svg></a> </h1> <a id="navtoggle"><span class="n">n</span><span class="a">a</span><span class="v">v</span></a>  <nav id="nav"> <ul> <li> <a href="https://asuragen.com/portfolio/">Portfolio</a> <div class="megadropdown"> <div class="col col1"> <h6 class="colhead"><a href="https://asuragen.com/portfolio/genetics/">Genetics</a></h6> <ul> <li><a href="https://asuragen.com/portfolio/genetics/amplidex-nanopore-carrier-plus-kit/">AmplideX® Nanopore Carrier Plus Kit [Coming Soon]</a></li> <li><a href="https://asuragen.com/portfolio/genetics/amplidex-mpcr-fmr1/">AmplideX® mPCR FMR1 Kit</a></li> <li><a href="https://asuragen.com/portfolio/genetics/amplidex-pcrce-fmr1/">AmplideX® PCR/CE FMR1 Kit</a></li> <li><a href="https://asuragen.com/portfolio/genetics/amplidex-fmr1-controls/">AmplideX® FMR1 Controls</a></li> <li><a href="/portfolio/genetics/xpansion-interpreter/">Xpansion Interpreter®</a></li> <li><a href="https://asuragen.com/portfolio/genetics/amplidex-pcrce-smn1-2-plus/">AmplideX® PCR/CE <em>SMN1/2</em> Plus Kit</a></li> <li><a href="https://asuragen.com/portfolio/genetics/amplidex-pcr-ce-cftr-kit/">AmplideX® PCR/CE <em>CFTR</em> Kit</a></li> <li><a href="https://asuragen.com/portfolio/genetics/amplidex-pcrce-c9orf72/">AmplideX® PCR/CE C9orf72 Kit</a></li> <li><a href="https://asuragen.com/portfolio/genetics/amplidex-pcrce-dmpk/">AmplideX® PCR/CE <em>DMPK</em> Kit</a></li> <li><a href="https://asuragen.com/portfolio/genetics/amplidex-pcr-ce-htt-kit/">AmplideX® PCR/CE <em>HTT</em> Kit</a></li> <li><a href="https://asuragen.com/portfolio/genetics/amplidex-trio/">AmplideX® TRIO</a></li> </ul> </div> <div class="col col2"> <h6 class="colhead"><a href="https://asuragen.com/portfolio/oncology/">Oncology</a></h6> <ul> <li><a href="https://asuragen.com/portfolio/oncology/quantidex-qpcr-bcr-abl-is-kit/">QuantideX® qPCR BCR-ABL IS Kit</a></li> <li><a href="https://asuragen.com/portfolio/oncology/quantidex-qpcr-bcr-abl-minor-kit/">QuantideX® qPCR BCR-ABL minor Kit</a></li> <li><a href="https://asuragen.com/portfolio/oncology/quantidex-esr1-exomutation-kit/">QuantideX® qPCR <em>ESR1</em> exoMutation Kit</a></li> <li><a href="https://asuragen.com/portfolio/oncology/quantidex-pml-rara/">QuantideX® qPCR PML-RARA Kit [Coming Soon]</a></li> </ul> </div> <div class="col col3"> <h6 class="colhead"><a href="https://asuragen.com/moleculardx-controls-portfolio/">MolecularDx Controls</a></h6> <ul> <li><a href="https://asuragen.com/moleculardx-controls-portfolio/mdx-catalog-products/">Catalog of Armored Products</a></li> <li><a href="https://asuragen.com/portfolio/armored-rna-quant-sars-cov-2-controls/">SARS CoV-2 Controls</a></li> <li><a href="https://asuragen.com/moleculardx-controls-portfolio/mdx-made-to-order-products/">Made-To-Order Armored and Nucleic Acid</a></li> <li><a href="https://asuragen.com/moleculardx-controls-portfolio/mdx-molecular-assay-reagents/">Molecular Assay Reagents</a></li> </ul> </div> <div class="col col4"> <h6 class="colhead"><a href="https://asuragen.com/companion-diagnostics/">Custom & Companion Diagnostics</a></h6> <ul> <li><a href=""></a></li> <li><a href=""></a></li> <li><a href=""></a></li> <li><a href=""></a></li> <li><a href=""></a></li> <li><a href=""></a></li> </ul> <h6 class="colhead"><a href="https://asuragen.com/partnered-rd/">Partnered R&D</a></h6> <ul> <li><a href="https://asuragen.com/licenses-accreditations/">CAP-Accredited CLIA Lab</a></li> <li><a href="https://asuragen.com/partnered-rd/">CTA Testing Site</a></li> <li><a href="https://asuragen.com/partnered-rd/">Validated Platforms & Assays</a></li> </ul> </div> </div> </li> <li> <a href="https://asuragen.com/companion-diagnostics/">Companion Diagnostics</a> </li> <li> <a href="https://asuragen.com/enabling-technologies/">Enabling Technologies</a> <ul class="dropdown"> <li><a href="https://asuragen.com/enabling-technologies/assay-chemistries/">Assay Chemistries</a></li> <li><a href="https://asuragen.com/enabling-technologies/bioinformatics/">Bioinformatics</a></li> <li><a href="https://asuragen.com/enabling-technologies/product-development-process/">Product Development Process</a></li> </ul> </li> <li> <a href="https://asuragen.com/resources/">Resources</a> <div class="megadropdown"> <div class="col col1"> <h6 class="colhead"><a href="https://asuragen.com/publications/">Publications</a></h6> <ul> <li><a href="https://asuragen.com/publications/?publication_type=published-article">Articles</a></li> <li><a href="https://asuragen.com/publications/?publication_type=white-paper">Whitepapers</a></li> <li><a href="https://asuragen.com/publications/?publication_type=poster">Posters</a></li> </ul> </div> <div class="col col2"> <h6 class="colhead"><a href="#">Disease Information</a></h6> <ul> <li><a href="https://asuragen.com/discoverfragilex/" target="_blank">Fragile X Syndrome</a></li> <li><a href="https://asuragen.com/resources/dementia/">Dementia</a></li> <li><a href="https://asuragen.com/cmlanswers/">Chronic Myeloid Leukemia (CML)</a></li> </ul> </div> <div class="col col3"> <h6 class="colhead"><a href="#">Other Resources</a></h6> <ul> <li><a href="https://asuragen.com/videos/">Videos</a></li> <li><a href="https://asuragen.com/carrier-screening/">Carrier Screening Guide</a></li> <li><a href="https://asuragen.com/resources/sds/">Safety Data Sheets</a></li> <li><a href="https://asuragen.com/sales-contacts/">Sales Contacts</a></li> </ul> </div> </div> </li> <li> <a href="https://asuragen.com/community/culture-and-heritage/">Our Culture</a> <ul class="dropdown"> <li><a href="https://asuragen.com/spotlight/">Employee Spotlights</a></li> <li><a href="https://asuragen.com/community/culture-and-heritage/">Culture & Heritage</a></li> </ul> </li> <li class="only-mobile"> <a href="https://asuragen.com/sales-contacts/">Sales Contacts</a> </li> </ul> </nav> <div id="secondary"> <nav class="secondary"> <ul> <li class="btn-item"><a href="https://asuragen.com/contact/" class="btn-link">Contact</a></li> <li class="btn-item"><a href="https://asuragen.com/emea/" class="btn-link -orange">EMEA</a></li> <li><a href="https://asuragen.com/about/">About</a> <ul class="dropdown"> <li><a href="https://asuragen.com/about/leadership-team/">Leadership Team</a></li> <li><a href="https://asuragen.com/community/culture-and-heritage/">Culture and Heritage</a></li> <li><a href="https://asuragen.com/news/">News</a></li> <li><a href="https://asuragen.com/upcoming-events/">Upcoming Events</a></li> <li><a href="https://asuragen.com/about/business-development/">Business Development</a></li> </ul> </li> <li><a href="https://asuragen.com/careers/">Careers</a></li> </ul> </nav> <div class="login"> <a href="https://asuragen.com/myasuragen"> <svg xmlns="http://www.w3.org/2000/svg" width="120" height="17.5" fill="none" viewBox="0 0 1315 192"><path fill="#415565" fill-rule="evenodd" d="M1110 100.5h-88.5c5 18.1 15.5 27.2 32 27.5 11.2.2 20.4-5 26-12l24.5 12a65.8 65.8 0 0 1-52.5 23A59.1 59.1 0 0 1 995 91c1-30.5 30-52.5 54-54s40.3 7.5 48.5 16c10.1 10.5 13 27.7 12.5 47.5ZM1023 80h59s-6.5-20.5-29-21-30 21-30 21Z" clip-rule="evenodd"/><path fill="#415565" d="M1021.5 100.5v-.5h-.7l.2.6.5-.1Zm88.5 0v.5h.5v-.5h-.5Zm-56.5 27.5v.5-.5Zm26-12 .2-.4-.3-.2-.3.3.4.3Zm24.5 12 .4.3.4-.5-.6-.2-.2.4Zm-52.5 23v.5-.5ZM995 91h-.5.5Zm54-54v.5-.5Zm48.5 16-.4.3.4-.3ZM1082 80v.5h.7l-.2-.6-.5.1Zm-59 0-.5-.2-.2.7h.7V80Zm-1.5 21h88.5v-1h-88.5v1Zm32 26.5a30.2 30.2 0 0 1-20-7 40 40 0 0 1-11.5-20.1l-1 .2a41 41 0 0 0 11.9 20.7c5.4 4.7 12.3 7 20.6 7.2v-1Zm25.6-11.8a32 32 0 0 1-25.6 11.8v1a33 33 0 0 0 26.4-12.2l-.8-.6Zm25.1 11.9-24.5-12-.4.8 24.5 12 .4-.8Zm-52.7 23.9c21.8 1 40.6-9.1 52.9-23.2l-.8-.6a65.3 65.3 0 0 1-52 22.8l-.1 1Zm-57-60.5c-1 30.8 23.7 59 57 60.5v-1a58.6 58.6 0 0 1-56-59.5h-1Zm54.5-54.5a61 61 0 0 0-36 16.3A54.4 54.4 0 0 0 994.5 91h1c.5-15 8-28 18.2-37.5a60 60 0 0 1 35.3-16v-1Zm48.9 16.2c-8.3-8.7-24.8-17.7-49-16.2l.1 1c23.9-1.5 40 7.5 48.1 15.8l.8-.6Zm12.6 47.8c.4-19.8-2.4-37.2-12.6-47.8l-.8.6c10 10.4 12.8 27.4 12.4 47.2h1Zm-28.5-21h-59v1h59v-1Zm-29-20a30 30 0 0 1 22.6 10.5 35 35 0 0 1 5.9 10v.1h.5l.5-.2v-.1l-.1-.2-.3-.7-1-2.3c-1-2-2.5-4.6-4.8-7.2a30.5 30.5 0 0 0-23.3-10.9v1ZM1023 80l.5.2v-.3l.3-.6 1.2-2.4c1-2 2.6-4.6 5-7.2 4.5-5.3 12-10.4 23-10.2v-1c-11.4-.2-19 5.1-23.8 10.5a38.1 38.1 0 0 0-6.3 9.9l-.3.7v.2l.4.2Zm59 .5h.5v-1h-.5v1Z"/><path fill="#415565" stroke="#415565" d="M1159.5 39.2H1132v109.5h27.5c0-51-.5-87.2 25-85.7s17 38.7 17 85.7h27.5v-76c0-15-6-24-17.5-31s-33-7.6-52 8.5v-11Z"/><path fill="#415565" d="M1264 1h-22v4h9v36h4V5h9V1Zm10.5 0h-1.5l-5 40h4l4-29 14 29h1.5l14.5-29 3 29h5l-6-40h-2l-15 32.5h-1L1274.5 1Z"/><path stroke="#415565" d="M1264 1h-22v4h9v36h4V5h9V1Zm10.5 0h-1.5l-5 40h4l4-29 14 29h1.5l14.5-29 3 29h5l-6-40h-2l-15 32.5h-1L1274.5 1Z"/><path fill="#415565" fill-rule="evenodd" d="M349 1.5h28.5l57 147h-30l-12-31H334l-12 31h-31l58-147Zm14 39-19.5 49h39l-19.5-49Z" clip-rule="evenodd"/><path fill="#415565" d="m377.5 1.5.5-.2-.2-.3h-.3v.5Zm-28.5 0V1h-.3l-.2.3.5.2Zm85.5 147v.5h.7l-.2-.7-.5.2Zm-30 0-.5.2.2.3h.3v-.5Zm-12-31 .5-.2-.2-.3h-.3v.5Zm-58.5 0v-.5h-.3l-.2.3.5.2Zm-12 31v.5h.3l.2-.3-.5-.2Zm-31 0-.5-.2-.2.7h.7v-.5Zm52.5-59-.5-.2-.2.7h.7v-.5Zm19.5-49 .5-.2-.5-1.2-.5 1.2.5.2Zm19.5 49v.5h.7l-.2-.7-.5.2Zm-5-88.5H349v1h28.5V1ZM435 148.3l-57-147-1 .4 57 147 1-.4Zm-30.5.7h30v-1h-30v1ZM392 117.7l12 31 1-.4-12-31-1 .4Zm-58 .3h58.5v-1H334v1Zm-11.5 30.7 12-31-1-.4-12 31 1 .4Zm-31.5.3h31v-1h-31v1ZM348.5 1.3l-58 147 1 .4 58-147-1-.4ZM344 89.7l19.5-49-1-.4-19.5 49 1 .4Zm38.5-.7h-39v1h39v-1Zm-20-48.3 19.5 49 1-.4-19.5-49-1 .4Z"/><path fill="#415565" stroke="#415565" d="M196.5 39.5H181l44.5 100-21 48.5H220l64.5-148.5H269l-36 83-36.5-83Z"/><path fill="#415565" d="M1 39.5h14.5V58C40 24 76 32 87 62.5c16-36 70.5-32.5 74-1.5 3.5 30.8 3.1 86.2 3.5 86.5h-14s0-64.5-1.5-76-5-21-23-22.5-31 13.5-33.5 25.5-3.2 44.8-2.5 73H76c-.1-28.8 0-58-1.5-73S66 49 50 49s-25 7.5-31 22.5-3.5 76-3.5 76H1v-108Z"/><path stroke="#415565" d="M1 39.5h14.5V58C40 24 76 32 87 62.5c16-36 70.5-32.5 74-1.5s3 86.8 3.5 86.5h-14s0-64.5-1.5-76-5-21-23-22.5-31 13.5-33.5 25.5-3.2 44.8-2.5 73H76c-.1-28.8 0-58-1.5-73S66 49 50 49s-25 7.5-31 22.5-3.5 76-3.5 76H1v-108Z"/><path fill="#415565" stroke="#415565" d="m501.8 71.5 18.7-17s-17-18.6-38-18.5c-21 .1-37.5 16-35 38.5s56 33.5 46 47S460 115 460 115l-17 18.5s22.5 15.5 36.5 17 39.4-2 41.5-33.5c2.1-31.5-47.7-40-47.7-51.5s22.2-1.5 28.5 6ZM569 39h-27.5s-2 47 0 71 17.5 40.5 48 41.5 46-20 48-41.5 0-71 0-71h-27s0 62-1.5 71-7 15-19.5 15.5a19.4 19.4 0 0 1-19-15.5c-1.5-7-1.5-71-1.5-71Zm112.5 0h-23v109h27v-.7c-.5-37.7-1-72.4 5-81.8 6-9.5 15-6 18.5-3.5l7.5-23c-1.5-.5-6-3.6-15.5-2.5s-12.5 4.5-19 15l-.5-12.5Z"/><path fill="#415565" fill-rule="evenodd" d="M811.5 39H839v109h-27.5v-11l-.9.5c-11 6.2-18.5 10.5-35.6 10.5-17.5 0-53-15-50-58.5S761.5 36 775 36a47 47 0 0 1 36.5 14.5V39ZM783 126c16.6 0 30-14.6 30-32.5 0-18-13.4-32.5-30-32.5s-30 14.6-30 32.5c0 18 13.4 32.5 30 32.5Z" clip-rule="evenodd"/><path fill="#415565" d="M839 39h.5v-.5h-.5v.5Zm-27.5 0v-.5h-.5v.5h.5ZM839 148v.5h.5v-.5h-.5Zm-27.5 0h-.5v.5h.5v-.5Zm0-11h.5v-.9l-.7.5.2.4Zm-.9.5.3.4-.3-.4Zm-85.6-48h.5-.5ZM775 36v-.5.5Zm36.5 14.5-.4.3.9 1v-1.3h-.5Zm27.5-12h-27.5v1H839v-1Zm.5 109.5V39h-1v109h1Zm-28 .5H839v-1h-27.5v1ZM811 137v11h1v-11h-1Zm-.1 1 .8-.6-.4-.8-1 .5.6.8ZM775 148.4c8.6 0 14.8-1 20.2-3 5.5-1.8 10.2-4.5 15.7-7.6l-.5-.8a59.5 59.5 0 0 1-35.4 10.4v1Zm-50.5-59a52.8 52.8 0 0 0 50.5 59v-1a51.8 51.8 0 0 1-49.5-58h-1Zm50.5-54c-6.8 0-18.7 2.5-29.2 10.5-10.6 8-19.8 21.6-21.3 43.5h1a55.6 55.6 0 0 1 20.9-42.6A50.3 50.3 0 0 1 775 36.5v-1Zm36.9 14.7A47.4 47.4 0 0 0 775 35.5v1c13.4 0 27.1 3.9 36.1 14.3l.8-.6ZM811 39v11.5h1V39h-1Zm1.5 54.5c0 17.7-13.2 32-29.5 32v1c16.9 0 30.5-14.8 30.5-33h-1Zm-29.5-32c16.3 0 29.5 14.3 29.5 32h1c0-18.2-13.6-33-30.5-33v1Zm-29.5 32c0-17.7 13.2-32 29.5-32v-1c-16.9 0-30.5 14.8-30.5 33h1Zm29.5 32c-16.3 0-29.5-14.3-29.5-32h-1c0 18.2 13.6 33 30.5 33v-1Z"/><path fill="#415565" fill-rule="evenodd" d="M946.5 39h27v104c0 28.5-25 49.4-56.5 48-27.5-1.2-43.7-6.5-56-34.5h31.5c1.5 4 7.5 10 26 10s30-10 28-31.5c-.6.2-1.4 1-2.4 2-3.7 3.6-11.3 11-32.1 11-26.5 0-51.5-25.5-51.5-56s19.2-54.4 48-56a49 49 0 0 1 38 14V39Zm-29 85c16.8 0 30.5-14.6 30.5-32.5 0-18-13.7-32.5-30.5-32.5S887 73.6 887 91.5c0 18 13.7 32.5 30.5 32.5Z" clip-rule="evenodd"/><path fill="#415565" d="M973.5 39h.5v-.5h-.5v.5Zm-27 0v-.5h-.5v.5h.5ZM917 191v.5-.5Zm-56-34.5v-.5h-.8l.3.7.5-.2Zm31.5 0 .5-.2-.2-.3h-.3v.5Zm54-21.5h.5v-.7l-.7.2.2.5Zm-2.4 2-.4-.4.4.3Zm-83.6-45h-.5.5Zm48-56v.5-.5Zm38 14-.3.4.8.7V50h-.5Zm27-11.5h-27v1h27v-1ZM974 143V39h-1v104h1Zm-57 48.5c31.7 1.4 57-19.7 57-48.5h-1c0 28.2-24.7 49-56 47.5v1Zm-56.5-34.8a53.4 53.4 0 0 0 22.6 27.5c9.1 5 20.1 6.7 33.9 7.3v-1a75.6 75.6 0 0 1-33.5-7.2c-8.9-4.9-16-13-22-27l-1 .4Zm32-.7H861v1h31.5v-1Zm26 10c-18.4 0-24.1-6-25.5-9.7l-1 .4c1.6 4.3 8 10.3 26.5 10.3v-1Zm27.5-31c1 10.7-1.4 18.4-6.2 23.5-4.8 5-12.1 7.5-21.3 7.5v1c9.3 0 17-2.5 22-7.8 5.1-5.4 7.5-13.4 6.5-24.2h-1Zm-1.6 2.3a26.9 26.9 0 0 1 2.3-1.8l-.4-1c-.4.2-.8.4-1.2.8l-1.4 1.3.7.7ZM912 148.5a53 53 0 0 0 22.7-4.2c5-2.4 7.9-5.2 9.7-7l-.7-.7a32 32 0 0 1-9.5 6.8 52 52 0 0 1-22.2 4.1v1ZM860 92c0 30.7 25.2 56.5 52 56.5v-1c-26.2 0-51-25.2-51-55.5h-1Zm48.5-56.5C879.4 37.1 860 61.3 860 92h1c0-30.3 19-54 47.5-55.5v-1Zm38.3 14.1c-6-5-11.6-8.8-17.7-11.2a48.1 48.1 0 0 0-20.6-2.9v1c7.9-.4 14.3.5 20.2 2.8 6 2.3 11.5 6 17.5 11l.6-.7ZM946 39v11h1V39h-1Zm1.5 52.5c0 17.7-13.5 32-30 32v1c17.1 0 31-14.8 31-33h-1Zm-30-32c16.5 0 30 14.3 30 32h1c0-18.2-13.9-33-31-33v1Zm-30 32c0-17.7 13.5-32 30-32v-1c-17.1 0-31 14.8-31 33h1Zm30 32c-16.5 0-30-14.3-30-32h-1c0 18.2 13.9 33 31 33v-1Z"/></svg> </a> </div> <nav class="social"> <a href="https://www.linkedin.com/company/asuragen" target="_blank"><svg viewBox="0 0 800 800"><path d="M268 629h-97V319h97zm157 0h-97V319h93v42h1q31-50 93-50 114 0 114 133v185h-96V466q0-70-49-70-59 0-59 69z"/><circle cx="219" cy="220" r="56"/></svg></a> <a href="https://twitter.com/Asuragen" target="_blank"><svg viewBox="0 0 800 800"><path d="M679 239s-21 34-55 57c7 156-107 329-314 329-103 0-169-50-169-50s81 17 163-45c-83-5-103-77-103-77s23 6 50-2c-93-23-89-110-89-110s23 14 50 14c-84-65-34-148-34-148s76 107 228 116c-22-121 117-177 188-101 37-6 71-27 71-27s-12 41-49 61c30-2 63-17 63-17z"/></svg></a> <a href="https://www.facebook.com/Asuragen/" target="_blank"><svg viewBox="0 0 800 800"><path d="M445 643h-90V419h-75v-87h75v-64q0-55 32-86 30-29 80-29 28 0 67 3v78h-47q-42 0-42 38v60h86l-11 87h-75v224z"/></svg></a> <a href="https://www.youtube.com/channel/UCJvWl3pIBYGT2HBZfwuSvXg" target="_blank"><svg viewBox="0 0 800 800" xmlns="http://www.w3.org/2000/svg"> <path d="M400 224c144 0 201 2 224 25 17 17 26 52.125 26 151s-9 134-26 151c-23 23-80 25-224 25s-201-2-224-25c-17-17-26-52.125-26-151s9-134 26-151c23-23 80-25 224-25zm-52 100v141l135-70z"/> </svg></a> <a href="https://vimeo.com/asuragen" target="_blank"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24"><path d="M21.063,10.38 C19.028,14.728 14.115,20.646 11.01,20.646 C7.95,20.646 7.508,14.12 5.837,9.777 C5.015,7.639 4.484,8.13 2.942,9.209 L2.002,7.997 C4.25,6.02 6.5,3.724 7.883,3.597 C9.44,3.448 10.398,4.512 10.756,6.79 C11.23,9.784 11.891,14.432 13.046,14.432 C13.946,14.432 16.164,10.745 16.278,9.427 C16.48,7.497 14.859,7.438 13.451,8.041 C15.679,0.746 24.945,2.089 21.063,10.38 z" /></svg></a> </nav> <a href="https://asuragen.com?s" class="search"> <i><svg xmlns="http://www.w3.org/2000/svg" version="1.1" viewBox="0 0 30 32"><path d="M30 26l-7.8-7.8c1.1-1.8 1.8-3.9 1.8-6.2 0-6.6-5.4-12-12-12s-12 5.4-12 12c0 6.6 5.4 12 12 12 2.3 0 4.4-0.7 6.2-1.8l7.8 7.8c0.5 0.5 1.5 0.5 2 0l2-2c0.5-0.5 0.5-1.5 0-2zM12 20c-4.4 0-8-3.6-8-8s3.6-8 8-8 8 3.6 8 8-3.6 8-8 8z"/></svg></i> Search </a> </div> </div> </header> <div class="masthead-none"></div> <div class="breadcrumbs"> <div class="bound-layout"> <nav> <a href="https://asuragen.com">Home</a><a href="https://asuragen.com/portfolio/">Portfolio</a><a href="https://asuragen.com/portfolio/genetics/">Kitted Assays for Inherited Genetic Disorders</a><a>AGG Interruption Testing Service</a> </nav> </div> </div> <div class="bound-layout layout-sidebar"> <div class="content"> <div class="solutions-detail"> <div class="solution-description" id="solution-us"> <h1>AGG Interruption Testing Service</h1> <p><a href="http://asuragen.com/wp-content/uploads/2020/07/banner-impage-for-xpansion-interpreter.jpg"><img loading="lazy" decoding="async" class="aligncenter wp-image-192240" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_860,h_573/https://asuragen.com/wp-content/uploads/2020/07/banner-impage-for-xpansion-interpreter.jpg" alt="" width="860" height="573" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_509/https://asuragen.com/wp-content/uploads/2020/07/banner-impage-for-xpansion-interpreter.jpg 509w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/07/banner-impage-for-xpansion-interpreter-300x200.jpg 300w" sizes="auto, (max-width: 860px) 100vw, 860px" /></a></p> <p><a class="btn -large -underline" href="#order" rel="noopener">Contact Us</a></p> <nav class="solutions-nav stacked"> <a href="#us-1">Overview</a> <a href="#us-2">Testing Service</a> <a href="#us-3">Obtaining Xpansion Interpreter®</a> <a href="#us-4">Contact Us</a> <a href="#us-5">Contact Us</a> <a href="#us-6">Resources</a> </nav> <div id="us-1" class="solutions-detail-content"> <h3 class="solution-subtitle">Overview</h3> <p>Testing for AGG interruptions within the <em>FMR1</em> CGG repetitive sequence may help refine the risk of transmitting fragile X syndrome to the next generation for certain premutation carriers. These AGG insertions “interrupt” the unstable CGG sequences and, as such, determining the number of these interruptions and their location may better inform on the risk of transmission.</p> <p><strong><span style="color: #005f9f;">Figure 1. </span></strong> Diagram of <em>FMR1</em> gene and AGG locations.</p> <p><a href="http://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter.jpg"><img loading="lazy" decoding="async" class="alignnone wp-image-192210" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_526,h_526/https://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter.jpg" alt="" width="526" height="526" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1000/https://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter.jpg 1000w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter-300x300.jpg 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_150/https://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter-150x150.jpg 150w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter-768x768.jpg 768w" sizes="auto, (max-width: 526px) 100vw, 526px" /></a></p> <p>Asuragen’s scientists collaborated with fragile X experts at the New York State Institute for Basic Research in Developmental Disabilities, Rush University Medical Center, Emory University School of Medicine, and the UC Davis M.I.N.D. Institute to conduct a large study to examine CGG repeats and AGG interruptions in 1,040 parent-to-child transmissions for alleles with 45-90 total repeats (<a href="https://pubmed.ncbi.nlm.nih.gov/25210937/" target="_blank" rel="noopener">Nolin, <em>et al.</em> 2015</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/23444167/#" target="_blank" rel="noopener">Nolin, <em>et al.</em> 2013</a>). The studies showed a clear modification of the probability of expansion, of variable sizes and degrees, when number and location of AGG interruptions and number of CGG repeats were considered.</p> <p> </p> <p><strong>The likelihood for expansion to a fragile X full mutation is based on the total number of CGG repeats and the number of AGG interruptions.</strong> In Figure 2 below, the grey bars represent the risk of expansion to a full mutation in the <u>absence</u> of knowledge of number of AGG interruptions. The lines represent the <u>modified risk</u> when AGG information is incorporated. As an example, an <em>FMR1</em> allele with 75-79 CGG repeats has a 10-fold greater risk of expansion with 0 AGG interruptions (74%) compared to 2 AGG interruptions (7%).<br /> Source: <a href="https://pubmed.ncbi.nlm.nih.gov/25210937/" target="_blank" rel="noopener">Nolin, <em>et al.</em> 2015</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/23444167/#" target="_blank" rel="noopener">Nolin, <em>et al.</em> 2013</a></p> <p><strong><span style="color: #005f9f;">Figure 2. </span></strong>Impact of AGG interruptions on risk of expansion to Full Mutation</p> <p><a href="http://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--scaled.jpg"><img loading="lazy" decoding="async" class="alignnone wp-image-192300" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_792,h_454/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--1024x587.jpg" alt="" width="792" height="454" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--1024x587.jpg 1024w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--300x172.jpg 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--768x440.jpg 768w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1536/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--1536x881.jpg 1536w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_2048/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--2048x1174.jpg 2048w" sizes="auto, (max-width: 792px) 100vw, 792px" /></a></p> <p> </p> <p> </p> <p>A recent study by Westemeyer, et al. (2020) analyzed the CGG repeats and AGG interruptions from 1,259 premutation women identified from carrier screening in the US. They found that the addition of AGG information adjusted the risk of passing on a full mutation fragile X gene to their child in 90% of women (Figure 3). This result emphasizes the importance of including AGG sequencing analysis as part of fragile X screening to provide the most comprehensive information about a women’s risk.</p> <p><strong><span style="color: #005f9f;">Figure 3.</span></strong> Reclassification of fragile X risk transmission based on AGG interruption status</p> <p><a href="http://asuragen.com/wp-content/uploads/2020/08/XI-Graphs.jpg"><img loading="lazy" decoding="async" class="alignnone wp-image-192298" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_747,h_363/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs-1024x497.jpg" alt="" width="747" height="363" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs-1024x497.jpg 1024w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs-300x146.jpg 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs-768x373.jpg 768w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1536/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs-1536x746.jpg 1536w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1574/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs.jpg 1574w" sizes="auto, (max-width: 747px) 100vw, 747px" /></a></p> <p> </p> </div> <div id="us-2" class="solutions-detail-content"> <h3 class="solution-subtitle">Testing Service</h3> <p>Asuragen’s Xpansion Interpreter<sup>®</sup> testing service employs three different PCR reactions for each DNA sample. Capillary electrophoresis (CE) of the products of one PCR reaction, called repeat-primed PCR, examines this distribution to allow accurate determination of total repeat size (Figure 4A). Characteristic signal “dips” occur at the site of AGG interruptions, as seen by the red arrows in Figure 4B and 4C. Additional information is needed to determine the exact locations of the AGGs in females because the presence of two alleles creates interpretation challenges. Two additional PCR reactions allow resolution of the AGG position and number in females. Through specialized training to interpret the results from all three PCR reactions, the Asuragen CLIA laboratory staff that run Xpansion Interpreter<sup>®</sup> are able to definitively determine the location of the AGG interruptions in both males and females.</p> <p><span style="color: #005f9f;"><strong><span style="color: #005f9f;">Figure 4.</span> </strong></span>Diagram of <em>FMR1</em> gene and AGG locations.</p> <p><strong>A)</strong> Uninterrupted male sample; <strong>B)</strong> Male sample with 3 AGG interruptions; <strong>C)</strong> Female sample with overlapping AGG interruptions. The red arrows point to where the AGG interruptions interfere with creation of PCR products.</p> <p><a href="http://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A.jpg"><img loading="lazy" decoding="async" class="alignnone wp-image-192275" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_717,h_357/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A-1024x510.jpg" alt="" width="717" height="357" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A-1024x510.jpg 1024w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A-300x149.jpg 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A-768x383.jpg 768w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1536/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A-1536x765.jpg 1536w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1794/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A.jpg 1794w" sizes="auto, (max-width: 717px) 100vw, 717px" /></a></p> <p><span style="color: #005f9f;"><strong><br /> <span style="color: #005f9f;">Table 1.</span></strong></span> Example of Xpansion Interpreter Results</p> <p><a href="http://asuragen.com/wp-content/uploads/2020/09/XI_Results.png"><img loading="lazy" decoding="async" class="alignnone size-large wp-image-192313" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024,h_512/https://asuragen.com/wp-content/uploads/2020/09/XI_Results-1024x512.png" alt="" width="1024" height="512" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024/https://asuragen.com/wp-content/uploads/2020/09/XI_Results-1024x512.png 1024w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/09/XI_Results-300x150.png 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/09/XI_Results-768x384.png 768w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1200/https://asuragen.com/wp-content/uploads/2020/09/XI_Results.png 1200w" sizes="auto, (max-width: 1024px) 100vw, 1024px" /></a></p> </div> <div id="us-3" class="solutions-detail-content"> <h3 class="solution-subtitle">Obtaining Xpansion Interpreter®</h3> <p>Xpansion Interpreter (AGG interruption testing) is provided as a service to specific carrier screening laboratories throughout the United States. If you would like information on how to obtain XI, please reach out to the following laboratories:</p> <div class="row-fluid"> <div class="span6 rhcol"> <p><img loading="lazy" decoding="async" class="alignnone wp-image-192216" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_279,h_78/https://asuragen.com/wp-content/uploads/2020/07/sema4.png" alt="" width="279" height="78" /></p> </div> <div class="span6 rhcol"> <p>Sema4: 1.212.241.8717</p> </div> </div> <div class="row-fluid"> <div class="span6 rhcol"><img loading="lazy" decoding="async" class="alignnone size-full wp-image-192215" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_290,h_75/https://asuragen.com/wp-content/uploads/2020/07/Natera-logo.png" alt="" width="290" height="75" /></div> <div class="rhcol span5"> <p>Natera: 1.650.249.9090</p> </div> </div> <div class="row-fluid"> <div class="span6 rhcol"> <p><img loading="lazy" decoding="async" class="alignnone size-full wp-image-192214" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_260,h_81/https://asuragen.com/wp-content/uploads/2020/07/progenity-logo.png" alt="" width="260" height="81" /></p> </div> <div class="span6 rhcol"> <p>Progenity: 1.855.293.2639</p> </div> </div> <div class="row-fluid"> <div class="span6 rhcol"><img loading="lazy" decoding="async" class="alignnone wp-image-192243 size-medium" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300,h_58/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-300x58.png" alt="" width="300" height="58" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-300x58.png 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-1024x197.png 1024w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-768x148.png 768w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1536/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-1536x295.png 1536w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_2048/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-2048x394.png 2048w" sizes="auto, (max-width: 300px) 100vw, 300px" /></div> <div class="rhcol span6"> <p>Myriad Women’s Health: 1.800.469.7423</p> </div> </div> <p> </p> </div> <div id="us-4" class="solutions-detail-content"> <h3 class="solution-subtitle">Contact Us</h3> <p><strong>Billing Questions:</strong> <a href="tel:8777728018">1.877.772.8018</a><br /> <strong>Provider Questions</strong>: <a href="tel:8777728018">1.877.772.8018</a><br /> <strong>Fax Number</strong>: 1.512.681.5205</p> <p>Do not send CONFIDENTIAL Patient and Protected Health Information to this email address. Please send all Patient and Protected Health Information to Asuragen via fax at 1.512.681.5205 or call Asuragen Client Services at <a href="tel:8777728018">1.877.772.8018</a>.</p> <p><a href="mailto:ClinicalLabSupport@Asuragen.com">Click here</a> to email Client Services.</p> <p><a href="https://asuragen.com/licenses-accreditations/">Click here</a> to view our Licenses and Accreditations</p> <p><strong>Address:</strong><br /> Asuragen, Inc.<br /> 2150 Woodward St., Ste. 100<br /> Austin, TX 78744 USA</p> <p> </p> </div> <div id="us-5" class="solutions-detail-content"> <h3 class="solution-subtitle">Contact Us</h3> <p id="order">Additional Questions? Contact The Team Directly</p> <p><script src="https://info.bio-techne.com/js/forms2/js/forms2.min.js"></script></p> <form id="mktoForm_9635"></form> <p><script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9635);</script></p> </div> <div id="us-6" class="solutions-detail-content"> <h3 class="solution-subtitle">Resources</h3> <p><strong><span style="color: #005f9f;">Brochure</span></strong></p> <p><span style="color: #435563;"><a style="color: #435563;" href="http://asuragen.com/wp-content/uploads/2022/01/genetics-xpansion-interpreter-brochure.pdf" target="_blank" rel="noopener">Xpansion Interpreter Brochure Download</a></span></p> <p><strong><span style="color: #005f9f;">Video</span></strong></p> <p><span style="color: #435563;"><a style="color: #435563;" href="https://info.bio-techne.com/WEB-ASU-2023-03-AGG-Webinar-X-Syndrome-Video-6651_01-LP.html" target="_blank" rel="noopener">AGG Webinar: Developments in Fragile X Syndrome</a></span></p> <p><strong><span style="color: #005f9f;">Posters </span></strong></p> <p><span style="color: #435563;"><a style="color: #435563;" href="https://asuragen.com/wp-content/uploads/2019/07/Poster-AGG.pdf" target="_blank" rel="noopener">Absence of AGG interruptions is a risk factor for a full mutation expansion among ethnically diversed FMR1 premutation carriers</a></span><br /> Noam Domniz, Liat Ries-Levavi, Yoram Cohen, Lilach Marom-Haham, Michal Berkenstadt, Elon Pras, Anne Glicksman, Nicole Tortora, Gary J. Latham, Andrew G. Hadd, Sarah L. Nolin and Shai E. Elizur</p> <p><span style="color: #435563;"><a style="color: #435563;" href="https://asuragen.com/publications-list/personalizing-risk-for-fmr1-premutation-carriers-insights-from-over-8000-agg-test-results/" target="_blank" rel="noopener">Personalizing Risk for FMR1 Premutation Carriers: Insights from over 8000 AGG Test Results</a></span><br /> Deepa Eveleigh, Erika Mitchen, and Alison Anderson</p> <p><strong><span style="color: #005f9f;">Publications</span></strong></p> <p>Westemeyer M <em>et al</em>.<br /> <strong>Clinical Experience With Carrier Screening in a General Population: Support for a Comprehensive Pan-Ethnic Approach</strong><br /> <em>Genet Med. 2020 May 5. doi: 10.1038/s41436-020-0807-4.</em></p> <p>Nolin SL <em>et al</em>.<br /> <strong>Expansions and Contractions of the FMR1 CGG Repeat in 5,508 Transmissions of Normal, Intermediate, and Premutation Alleles</strong><br /> <em>Am J Med Genet A. 2019 Jul;179(7):1148-1156.</em></p> <p>Nolin SL <em>et al</em>.<br /> <a href="https://pubmed.ncbi.nlm.nih.gov/25210937/" target="_blank" rel="noopener"><strong>Fragile X full mutation expansions are inhibited by one or more AGG interruptions in premutation carriers.</strong></a><br /> <em>Genet Med 2015 May;17(5):358-64.</em></p> <p>Latham GJ et al.<br /> <strong>The role of AGG interruptions in fragile X repeat expansions: a twenty-year perspective<br /> </strong>Front Genet. 2014; 5: 244. doi: 10.3389/fgene.2014.00244</p> <p>Yrigollen CM <em>et al</em>.<br /> <strong>Transmission of an </strong><em><strong>FMR1</strong></em><strong> permutation allele in a large family identified through newborn screening: the role of AGG interruptions.</strong><br /> <em>J Hum Genet 2013; 1-7.</em></p> <p>Nolin SL <em>et al</em>.<br /> <a href="https://pubmed.ncbi.nlm.nih.gov/23444167/#" target="_blank" rel="noopener"><strong>Fragile X AGG analysis provides new risk predictions for 45-69 repeat alleles.</strong></a><br /> <em>Am J Med Genet 2013; 161(4):771-8.</em></p> <p>Yrigollen CM <em>et al</em>.<br /> <strong>AGG interruptions within the maternal </strong><em><strong>FMR1</strong></em><strong> gene reduce the risk of offspring with fragile X syndrome.</strong><br /> <em>Genet Med 2012; 14(8):729-36.</em></p> <p>Saul RA and Tarleton JC.<br /> <strong>FMR1-Related Disorders. In: Pagon RA, Bird TD, Dolan CR, Stephens K, Adam MP, editors.</strong><br /> <em>GeneReviews™[Internet]. Seattle (WA): University of Washington, Seattle; 1993-1998 June 16 [updated 2012 Apr 26].</em></p> <p>Nolin SL <em>et al</em>.<br /> <strong>Fragile X analysis of 1112 prenatal samples from 1991 to 2010.</strong><br /> <em>Prenat Diagn 2011; 31(10):925-31.</em></p> <p><strong>American College of Obstetricians and Gynecologists Committee on Genetics. Carrier screening for fragile X syndrome.</strong><br /> <em>Obstet Gyn 2010; 116(4):1008-10.</em></p> <p>Chen L <em>et al</em>.<br /> <strong>An information-rich CGG repeat primed PCR that detects the full range of fragile X expanded alleles and minimizes the need for southern blot analysis.</strong><br /> <em>J Mol Diag 2010; 12(5): 589-600.</em></p> <p>Filipovic-Sadic S <em>et al</em>.<br /> <strong>A Novel </strong><em><strong>FMR1</strong></em><strong> PCR method for the routine detection of low abundance expanded alleles and full mutations in Fragile X Syndrome.</strong><br /> <em>Clin Chem 2010; 56(3): 399-408.</em></p> <p><strong><span style="color: #005f9f;">Testing Guidelines</span> </strong></p> <p><strong>American College of Obstetricians and Gynecologists Committee on Genetics. Carrier screening for fragile X syndrome.</strong><strong>Obstet Gynecol</strong>. 2017 Mar;129(3):e41-e55</p> <p>Finucane B <em>et al</em>.<br /> <strong>Genetic counseling and testing for </strong><em><strong>FMR1</strong></em><strong> gene mutations: Practice guidelines of the National Society of Genetic Counselors.</strong><br /> <em>J Genet Counsel 2012; 21(6):752-60.</em></p> <p>Xpansion Interpreter is a laboratory-developed test. Analytical and clinical performance have not been reviewed by the FDA.</p> </div> </div> <div class="solution-description" id="solution-non-us"> <h1>AGG Interruption Testing Service</h1> <p><a href="http://asuragen.com/wp-content/uploads/2020/07/banner-impage-for-xpansion-interpreter.jpg"><img loading="lazy" decoding="async" class="aligncenter wp-image-192240" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_860,h_573/https://asuragen.com/wp-content/uploads/2020/07/banner-impage-for-xpansion-interpreter.jpg" alt="" width="860" height="573" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_509/https://asuragen.com/wp-content/uploads/2020/07/banner-impage-for-xpansion-interpreter.jpg 509w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/07/banner-impage-for-xpansion-interpreter-300x200.jpg 300w" sizes="auto, (max-width: 860px) 100vw, 860px" /></a></p> <nav class="solutions-nav"> <a href="#non-us-1">Overview</a> <a href="#non-us-2">Testing Service</a> <a href="#non-us-3">Obtaining Xpansion Interpreter®</a> <a href="#non-us-4">Contact Us</a> <a href="#non-us-5">Contact Us</a> <a href="#non-us-6">Resources</a> </nav> <div id="non-us-1" class="solutions-detail-content"> <h3 class="solution-subtitle">Overview</h3> <p>Testing for AGG interruptions within the <em>FMR1</em> CGG repetitive sequence may help refine the risk of transmitting fragile X syndrome to the next generation for certain premutation carriers. These AGG insertions “interrupt” the unstable CGG sequences and, as such, determining the number of these interruptions and their location may better inform on the risk of transmission.</p> <p><strong><span style="color: #005f9f;">Figure 1. </span></strong> Diagram of <em>FMR1</em> gene and AGG locations</p> <p><a href="http://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter.jpg"><img loading="lazy" decoding="async" class="alignnone wp-image-192210" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_529,h_529/https://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter.jpg" alt="" width="529" height="529" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1000/https://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter.jpg 1000w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter-300x300.jpg 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_150/https://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter-150x150.jpg 150w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/07/Figure-1-Xpansion-Interpreter-768x768.jpg 768w" sizes="auto, (max-width: 529px) 100vw, 529px" /></a></p> <p>Asuragen’s scientists collaborated with fragile X experts at the New York State Institute for Basic Research in Developmental Disabilities, Rush University Medical Center, Emory University School of Medicine, and the UC Davis M.I.N.D. Institute to conduct a large study to examine CGG repeats and AGG interruptions in 1,040 parent-to-child transmissions for alleles with 45-90 total repeats (<a href="https://pubmed.ncbi.nlm.nih.gov/25210937/" target="_blank" rel="noopener">Nolin, <em>et al.</em> 2015</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/23444167/#" target="_blank" rel="noopener">Nolin, <em>et al.</em> 2013</a>). The studies showed a clear modification of the probability of expansion, of variable sizes and degrees, when number and location of AGG interruptions and number of CGG repeats were considered.</p> <p> </p> <p><strong>The likelihood for expansion to a fragile X full mutation is based on the total number of CGG repeats and the number of AGG interruptions.</strong> In Figure 2 below, the grey bars represent the risk of expansion to a full mutation in the <u>absence</u> of knowledge of number of AGG interruptions. The lines represent the <u>modified risk</u> when AGG information is incorporated. As an example, an <em>FMR1</em> allele with 75-79 CGG repeats has a 10-fold greater risk of expansion with 0 AGG interruptions (74%) compared to 2 AGG interruptions (7%).<br /> Source: <a href="https://pubmed.ncbi.nlm.nih.gov/25210937/" target="_blank" rel="noopener">Nolin, <em>et al.</em> 2015</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/23444167/#" target="_blank" rel="noopener">Nolin, <em>et al.</em> 2013</a></p> <p><strong><span style="color: #005f9f;">Figure 2. </span></strong>Impact of AGG interruptions on risk of expansion to Full Mutation</p> <p><strong><a href="http://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--scaled.jpg"><img loading="lazy" decoding="async" class="alignnone wp-image-192300" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_792,h_454/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--1024x587.jpg" alt="" width="792" height="454" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--1024x587.jpg 1024w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--300x172.jpg 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--768x440.jpg 768w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1536/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--1536x881.jpg 1536w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_2048/https://asuragen.com/wp-content/uploads/2020/09/Figure-2-XI--2048x1174.jpg 2048w" sizes="auto, (max-width: 792px) 100vw, 792px" /></a></strong></p> <p>A recent study by Westemeyer, et al. (2020) analyzed the CGG repeats and AGG interruptions from 1,259 premutation women identified from carrier screening in the US. They found that the addition of AGG information adjusted the risk of passing on a full mutation fragile X gene to their child in 90% of women (Figure 3). This result emphasizes the importance of including AGG sequencing analysis as part of fragile X screening to provide the most comprehensive information about a women’s risk.</p> <p><strong><span style="color: #005f9f;">Figure 3.</span> </strong>Reclassification of fragile X risk transmission based on AGG interruption status</p> <p><a href="http://asuragen.com/wp-content/uploads/2020/08/XI-Graphs.jpg"><img loading="lazy" decoding="async" class="alignnone wp-image-192298" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_747,h_363/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs-1024x497.jpg" alt="" width="747" height="363" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs-1024x497.jpg 1024w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs-300x146.jpg 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs-768x373.jpg 768w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1536/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs-1536x746.jpg 1536w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1574/https://asuragen.com/wp-content/uploads/2020/08/XI-Graphs.jpg 1574w" sizes="auto, (max-width: 747px) 100vw, 747px" /></a></p> <p> </p> </div> <div id="non-us-2" class="solutions-detail-content"> <h3 class="solution-subtitle">Testing Service</h3> <p>Asuragen’s Xpansion Interpreter<sup>®</sup> testing service employs three different PCR reactions for each DNA sample. Capillary electrophoresis (CE) of the products of one PCR reaction, called repeat-primed PCR, examines this distribution to allow accurate determination of total repeat size (Figure 4A). Characteristic signal “dips” occur at the site of AGG interruptions, as seen by the red arrows in Figure 4B and 4C. Additional information is needed to determine the exact locations of the AGGs in females because the presence of two alleles creates interpretation challenges. Two additional PCR reactions allow resolution of the AGG position and number in females. Through specialized training to interpret the results from all three PCR reactions, the Asuragen CLIA laboratory staff that run Xpansion Interpreter<sup>®</sup> are able to definitively determine the location of the AGG interruptions in both males and females.</p> <p><span style="color: #005f9f;"><strong>Figure 4. </strong></span>Diagram of <em>FMR1</em> gene and AGG locations.</p> <p><strong>A)</strong> Uninterrupted male sample; <strong>B)</strong> Male sample with 3 AGG interruptions; <strong>C)</strong> Female sample with overlapping AGG interruptions. The red arrows point to where the AGG interruptions interfere with creation of PCR products.</p> <p><a href="http://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A.jpg"><img loading="lazy" decoding="async" class="alignnone wp-image-192275" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_717,h_357/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A-1024x510.jpg" alt="" width="717" height="357" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A-1024x510.jpg 1024w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A-300x149.jpg 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A-768x383.jpg 768w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1536/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A-1536x765.jpg 1536w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1794/https://asuragen.com/wp-content/uploads/2020/08/Xpansion-interpreter-figure-3A.jpg 1794w" sizes="auto, (max-width: 717px) 100vw, 717px" /></a></p> <p><span style="color: #005f9f;"><strong><br /> <span style="color: #005f9f;">Table 1. </span></strong></span>Example of Xpansion Interpreter Results<span style="color: #005f9f;"><strong><br /> </strong></span></p> <p><a href="http://asuragen.com/wp-content/uploads/2020/09/XI_Results.png"><img loading="lazy" decoding="async" class="size-large wp-image-192313 alignnone" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024,h_512/https://asuragen.com/wp-content/uploads/2020/09/XI_Results-1024x512.png" alt="" width="1024" height="512" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024/https://asuragen.com/wp-content/uploads/2020/09/XI_Results-1024x512.png 1024w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/09/XI_Results-300x150.png 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/09/XI_Results-768x384.png 768w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1200/https://asuragen.com/wp-content/uploads/2020/09/XI_Results.png 1200w" sizes="auto, (max-width: 1024px) 100vw, 1024px" /></a></p> </div> <div id="non-us-3" class="solutions-detail-content"> <h3 class="solution-subtitle">Obtaining Xpansion Interpreter®</h3> <p>Xpansion Interpreter (AGG interruption testing) is provided as a service to specific carrier screening laboratories throughout the United States. If you would like information on how to obtain XI, please reach out to the following laboratories:</p> <div class="row-fluid"> <div class="span6 rhcol"> <p><img loading="lazy" decoding="async" class="alignnone wp-image-192216" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_279,h_78/https://asuragen.com/wp-content/uploads/2020/07/sema4.png" alt="" width="279" height="78" /></p> </div> <div class="span6 rhcol"> <p>Sema4: 1.212.241.8717</p> </div> </div> <div class="row-fluid"> <div class="span6 rhcol"><img loading="lazy" decoding="async" class="alignnone size-full wp-image-192215" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_290,h_75/https://asuragen.com/wp-content/uploads/2020/07/Natera-logo.png" alt="" width="290" height="75" /></div> <div class="rhcol span5"> <p>Natera: 1.650.249.9090</p> </div> </div> <div class="row-fluid"> <div class="span6 rhcol"> <p><img loading="lazy" decoding="async" class="alignnone size-full wp-image-192214" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_260,h_81/https://asuragen.com/wp-content/uploads/2020/07/progenity-logo.png" alt="" width="260" height="81" /></p> </div> <div class="span6 rhcol"> <p>Progenity: 1.855.293.2639</p> </div> </div> <div class="row-fluid"> <div class="span6 rhcol"><img loading="lazy" decoding="async" class="alignnone wp-image-192243 size-medium" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300,h_58/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-300x58.png" alt="" width="300" height="58" srcset="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_300/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-300x58.png 300w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-1024x197.png 1024w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_768/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-768x148.png 768w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1536/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-1536x295.png 1536w, https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_2048/https://asuragen.com/wp-content/uploads/2020/07/cropped-myriad_womenshealth_logo_helix-04-2048x394.png 2048w" sizes="auto, (max-width: 300px) 100vw, 300px" /></div> <div class="rhcol span6"> <p>Myriad Women’s Health: 1.800.469.7423</p> </div> </div> <p> </p> </div> <div id="non-us-4" class="solutions-detail-content"> <h3 class="solution-subtitle">Contact Us</h3> <p><strong>Billing Questions:</strong> <a href="tel:8777728018">1.877.772.8018</a><br /> <strong>Provider Questions</strong>: <a href="tel:8777728018">1.877.772.8018</a><br /> <strong>Fax Number</strong>: 1.512.681.5205</p> <p>Do not send CONFIDENTIAL Patient and Protected Health Information to this email address. Please send all Patient and Protected Health Information to Asuragen via fax at 1.512.681.5205 or call Asuragen Client Services at <a href="tel:8777728018">1.877.772.8018</a>.</p> <p><a href="mailto:ClinicalLabSupport@Asuragen.com">Click here</a> to email Client Services.</p> <p><a href="https://asuragen.com/licenses-accreditations/">Click here</a> to view our Licenses and Accreditations</p> <p><strong>Address:</strong><br /> Asuragen, Inc.<br /> 2150 Woodward St., Ste. 100<br /> Austin, TX 78744 USA</p> <p> </p> </div> <div id="non-us-5" class="solutions-detail-content"> <h3 class="solution-subtitle">Contact Us</h3> <p>Additional Questions? Contact The Team Directly</p> <p><a class="btn -icon -underline" href="https://asuragen.com/contact/" rel="noopener">Contact Us Here</a></p> </div> <div id="non-us-6" class="solutions-detail-content"> <h3 class="solution-subtitle">Resources</h3> <p><strong><span style="color: #005f9f;">Brochure</span></strong></p> <p><span style="color: #435563;"><a style="color: #435563;" href="http://asuragen.com/wp-content/uploads/2022/01/genetics-xpansion-interpreter-brochure.pdf" target="_blank" rel="noopener">Xpansion Interpreter Brochure Download</a></span></p> <p><strong><span style="color: #005f9f;">Video</span></strong></p> <p><span style="color: #435563;"><a style="color: #435563;" href="https://info.bio-techne.com/WEB-ASU-2023-03-AGG-Webinar-X-Syndrome-Video-6651_01-LP.html" target="_blank" rel="noopener">AGG Webinar: Developments in Fragile X Syndrome</a></span></p> <p><strong><span style="color: #005f9f;">Posters </span></strong></p> <p><span style="color: #435563;"><a style="color: #435563;" href="https://asuragen.com/wp-content/uploads/2019/07/Poster-AGG.pdf" target="_blank" rel="noopener">Absence of AGG interruptions is a risk factor for a full mutation expansion among ethnically diversed FMR1 premutation carriers</a></span><br /> Noam Domniz, Liat Ries-Levavi, Yoram Cohen, Lilach Marom-Haham, Michal Berkenstadt, Elon Pras, Anne Glicksman, Nicole Tortora, Gary J. Latham, Andrew G. Hadd, Sarah L. Nolin and Shai E. Elizur</p> <p><span style="color: #435563;"><a style="color: #435563;" href="https://asuragen.com/publications-list/personalizing-risk-for-fmr1-premutation-carriers-insights-from-over-8000-agg-test-results/" target="_blank" rel="noopener">Personalizing Risk for FMR1 Premutation Carriers: Insights from over 8000 AGG Test Results</a></span><br /> Deepa Eveleigh, Erika Mitchen, and Alison Anderson</p> <p><strong><span style="color: #005f9f;">Publications</span></strong></p> <p>Westemeyer M <em>et al</em>.<br /> <strong>Clinical Experience With Carrier Screening in a General Population: Support for a Comprehensive Pan-Ethnic Approach</strong><br /> <em>Genet Med. 2020 May 5. doi: 10.1038/s41436-020-0807-4.</em></p> <p>Nolin SL <em>et al</em>.<br /> <strong>Expansions and Contractions of the FMR1 CGG Repeat in 5,508 Transmissions of Normal, Intermediate, and Premutation Alleles</strong><br /> <em>Am J Med Genet A. 2019 Jul;179(7):1148-1156.</em></p> <p>Nolin SL <em>et al</em>.<br /> <a href="https://pubmed.ncbi.nlm.nih.gov/25210937/" target="_blank" rel="noopener"><strong>Fragile X full mutation expansions are inhibited by one or more AGG interruptions in premutation carriers.</strong></a><br /> <em>Genet Med 2015 May;17(5):358-64.</em></p> <p>Latham GJ et al.<br /> <strong>The role of AGG interruptions in fragile X repeat expansions: a twenty-year perspective<br /> </strong>Front Genet. 2014; 5: 244. doi: 10.3389/fgene.2014.00244</p> <p>Yrigollen CM <em>et al</em>.<br /> <strong>Transmission of an </strong><em><strong>FMR1</strong></em><strong> permutation allele in a large family identified through newborn screening: the role of AGG interruptions.</strong><br /> <em>J Hum Genet 2013; 1-7.</em></p> <p>Nolin SL <em>et al</em>.<br /> <a href="https://pubmed.ncbi.nlm.nih.gov/23444167/#" target="_blank" rel="noopener"><strong>Fragile X AGG analysis provides new risk predictions for 45-69 repeat alleles.</strong></a><br /> <em>Am J Med Genet 2013; 161(4):771-8.</em></p> <p>Yrigollen CM <em>et al</em>.<br /> <strong>AGG interruptions within the maternal </strong><em><strong>FMR1</strong></em><strong> gene reduce the risk of offspring with fragile X syndrome.</strong><br /> <em>Genet Med 2012; 14(8):729-36.</em></p> <p>Saul RA and Tarleton JC.<br /> <strong>FMR1-Related Disorders. In: Pagon RA, Bird TD, Dolan CR, Stephens K, Adam MP, editors.</strong><br /> <em>GeneReviews™[Internet]. Seattle (WA): University of Washington, Seattle; 1993-1998 June 16 [updated 2012 Apr 26].</em></p> <p>Nolin SL <em>et al</em>.<br /> <strong>Fragile X analysis of 1112 prenatal samples from 1991 to 2010.</strong><br /> <em>Prenat Diagn 2011; 31(10):925-31.</em></p> <p><strong>American College of Obstetricians and Gynecologists Committee on Genetics. Carrier screening for fragile X syndrome.</strong><br /> <em>Obstet Gyn 2010; 116(4):1008-10.</em></p> <p>Chen L <em>et al</em>.<br /> <strong>An information-rich CGG repeat primed PCR that detects the full range of fragile X expanded alleles and minimizes the need for southern blot analysis.</strong><br /> <em>J Mol Diag 2010; 12(5): 589-600.</em></p> <p>Filipovic-Sadic S <em>et al</em>.<br /> <strong>A Novel </strong><em><strong>FMR1</strong></em><strong> PCR method for the routine detection of low abundance expanded alleles and full mutations in Fragile X Syndrome.</strong><br /> <em>Clin Chem 2010; 56(3): 399-408.</em></p> <p><strong><span style="color: #4298cc;">Testing Guidelines</span> </strong></p> <p><strong>American College of Obstetricians and Gynecologists Committee on Genetics. Carrier screening for fragile X syndrome.</strong><strong>Obstet Gynecol</strong>. 2017 Mar;129(3):e41-e55</p> <p>Finucane B <em>et al</em>.<br /> <strong>Genetic counseling and testing for </strong><em><strong>FMR1</strong></em><strong> gene mutations: Practice guidelines of the National Society of Genetic Counselors.</strong><br /> <em>J Genet Counsel 2012; 21(6):752-60.</em></p> <p>Xpansion Interpreter is a laboratory-developed test. Analytical and clinical performance have not been reviewed by the FDA.</p> </div> </div> </div> </div> <div class="sidebar"> <div class="sidenav"> <h4>Asuragen Genetics</h4> <div class="solutions-image"> <img decoding="async" src="https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img/https://asuragen.com/wp-content/uploads/2016/04/Amplidex_logo_4c-300x60-290x0-c-default.png" alt="AGG Interruption Testing Service Logo" /> </div> <nav> <div class="menu-asuragen-genetics-container"><ul id="menu-asuragen-genetics" class="menu"><li id="menu-item-194651" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-194651"><a href="https://asuragen.com/portfolio/genetics/amplidex-mpcr-fmr1/">AmplideX mPCR FMR1 Kit</a></li> <li id="menu-item-369" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-369"><a href="https://asuragen.com/portfolio/genetics/amplidex-pcrce-fmr1/">AmplideX PCR/CE FMR1</a></li> <li id="menu-item-371" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-371"><a href="https://asuragen.com/portfolio/genetics/amplidex-fmr1-controls/">AmplideX FMR1 Controls</a></li> <li id="menu-item-192355" class="menu-item menu-item-type-post_type menu-item-object-page current-menu-item page_item page-item-192208 current_page_item menu-item-192355"><a href="https://asuragen.com/portfolio/genetics/xpansion-interpreter/" aria-current="page">AGG Interruption Testing Service</a></li> <li id="menu-item-192199" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-192199"><a href="https://asuragen.com/portfolio/genetics/amplidex-pcrce-smn1-2-plus/">AmplideX PCR/CE <em>SMN1/2</em> Plus Kit</a></li> <li id="menu-item-193056" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-193056"><a href="https://asuragen.com/portfolio/genetics/amplidex-pcr-ce-cftr-kit/">AmplideX PCR/CE <em>CFTR</em> Kit</a></li> <li id="menu-item-2884" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2884"><a href="https://asuragen.com/portfolio/genetics/amplidex-pcrce-c9orf72/">AmplideX PCR/CE C9orf72 Kit</a></li> <li id="menu-item-189459" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-189459"><a href="https://asuragen.com/portfolio/genetics/amplidex-pcrce-dmpk/">AmplideX PCR/CE <em>DMPK</em> Kit</a></li> <li id="menu-item-190075" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-190075"><a href="https://asuragen.com/portfolio/genetics/amplidex-pcr-ce-htt-kit/">AmplideX PCR/CE <em>HTT</em> Kit</a></li> <li id="menu-item-195291" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-195291"><a href="https://asuragen.com/portfolio/genetics/amplidex-nanopore-carrier-plus-kit/">Coming Soon: AmplideX Nanopore Carrier Plus Kit<sup>*†</sup></a></li> </ul></div> </nav> </div> <div class="quick-links"> <h5>Quick Links</h5> <nav> <a href="http://asuragen.com/wp-content/uploads/2022/01/genetics-xpansion-interpreter-brochure.pdf" target="">Download Product Brochure</a> </nav> </div> </div> </div> <a class="back-to-top" href="#">Back To<br>Top</a> <footer id="footer"> <div class="bound-footer"> <div class="left"> <div class="vcard"> <div class="fn org" style="display: none;">Asuragen, Inc.</div> <a href="https://asuragen.com" class="logo"> <svg xmlns="http://www.w3.org/2000/svg" fill-rule="evenodd" stroke-linejoin="round" stroke-miterlimit="2" clip-rule="evenodd" viewBox="0 0 400 210"><path fill-rule="nonzero" d="M175.7 99.3a19.5 19.5 0 0 0-6.4 4.6v-5.5H159v47.4h10.3v-21.1c0-4.5 1.3-8.5 3.8-11.7a12 12 0 0 1 10-5h2.7V97.7h-2.3c-3 0-5.6.5-7.8 1.6zm208.4 4a17 17 0 0 0-6.2-4c-2.3-1-5-1.4-8.1-1.4a16 16 0 0 0-8.8 2.5 25 25 0 0 0-2.9 2.1v-3.9h-10.3V146h10.3v-27a10.9 10.9 0 0 1 11.3-11.4c3 0 5.5 1 7.4 3 2 2 3 4.8 3 8.3V146H390v-27.3c0-6.3-2-11.4-5.9-15.3zm-244 22.3A10.9 10.9 0 0 1 129 137c-3.1 0-5.6-1-7.5-3-1.9-2-2.9-4.8-2.9-8.3v-27h-10.3v27.2c0 6.3 2 11.5 6 15.3a17.1 17.1 0 0 0 6.1 4.1c2.3 1 5 1.4 8.2 1.4a16 16 0 0 0 8.8-2.5c1-.6 2-1.3 2.8-2.1v3.9h10.4V98.6H140v27zm-99.7-6.1H22.5l9-21.4 8.9 21.4zm-3.6-35H26.1L0 146h11.3l7.1-16.7h26.1l7 16.7H63L37 85l-.2-.5zm57.5 35.3c-2.2-1-4.7-1.6-7.4-2.2A101.2 101.2 0 0 1 80 116c-2-.5-3.5-1.2-4.8-2-.9-.5-1.3-1.2-1.3-2.3 0-1.2 0-4.4 8.2-4.4 7 0 8.6 2.5 9 4.6l9.8-3a14.2 14.2 0 0 0-4.5-6.7 21 21 0 0 0-13.8-4.3c-6 0-10.7 1.3-14 3.7-3.3 2.5-5 6.1-5 10.7 0 3.1 1 5.7 2.7 7.6a17 17 0 0 0 6 4 40 40 0 0 0 7.4 2.1 89 89 0 0 1 6.8 1.7c2 .5 3.6 1.2 4.9 2a3 3 0 0 1 1.3 2.6c0 2-1 3.1-3 4-1 .4-2.2.6-3.3.8a18 18 0 0 1-7.8-.4c-3-1-4.7-2.8-5.3-5.5l-8.8 6.3a15.2 15.2 0 0 0 3.7 4.4c3.8 3.2 8.9 4.8 15 4.8a24 24 0 0 0 14.2-3.7 13 13 0 0 0 5.6-11.3c0-3.2-1-5.8-2.7-7.7a16.9 16.9 0 0 0-6-4.2zm214.2-8.9c2.4-2.2 5.2-3.3 8.8-3.3a12.5 12.5 0 0 1 12.5 9.3h-25a13 13 0 0 1 3.7-6zm18.5 22.4a11.6 11.6 0 0 1-9.2 3.7c-3.8 0-6.9-1.1-9.3-3.5-2-1.8-3.2-4-3.8-6.7h36.1v-4.5c0-6.9-2.1-12.7-6.3-17.2a22.6 22.6 0 0 0-17.2-7.2c-7 0-12.8 2.4-17.3 7.2a24.7 24.7 0 0 0-6.2 17.2c0 6.9 2.2 12.7 6.5 17.3a23 23 0 0 0 17.4 7.1 23 23 0 0 0 13.8-4c1.4-1 2.5-2.1 3.6-3.4l-8-6zm-63.4 2.6a13.9 13.9 0 1 1 0-27.8 13.9 13.9 0 0 1 0 27.8zm13-37.3v4c-3.5-3.1-8-4.7-13.2-4.7-7.1 0-13 2.4-17.2 7.1a24.2 24.2 0 0 0-6.3 17c0 6.7 2.1 12.4 6.3 17 4.3 4.6 10 7 16.7 7 5.5 0 10.1-1.6 13.7-4.7v1c0 4-1 7-2.8 9-2 2-5.2 3-9.7 3-5.7 0-9.3-1.8-10.9-5.5l-8.4 6c1.3 2 3 3.9 5.2 5.3 3.7 2.6 8.9 3.9 15.3 3.9 6.5 0 11.7-1.9 15.7-5.5s6-8.9 6-15.7V98.6h-10.4zM210.5 136a13.9 13.9 0 1 1 0-27.8 13.9 13.9 0 0 1 0 27.8zm13-37.3v4c-3.5-3.1-8-4.7-13.2-4.7a22 22 0 0 0-17.2 7.2 25 25 0 0 0-6.3 17.2 25 25 0 0 0 6.3 17.2c4.3 4.8 10 7.2 16.7 7.2 5.5 0 10.2-1.6 13.7-4.6v3.9H234V98.6h-10.4z" class="asuragen"/><path fill="#ee6d20" fill-rule="nonzero" d="M195 0a108 108 0 0 0-45.5 9.1 87.4 87.4 0 0 0-20.4 13.7 72.5 72.5 0 0 0 29.3 34A170 170 0 0 1 195 24.1c13-7.9 28.6-13 45.5-15A110 110 0 0 0 195 0z"/><path fill="#005f9f" fill-rule="nonzero" d="m246.2 12.2-5.3.6a110.7 110.7 0 0 0-42.4 13.6 247 247 0 0 1 33.9 29.8A71.7 71.7 0 0 0 261 22.7a99 99 0 0 0-14.8-10.5zM19.7 192.5l-3.8-.2c-3.2 0-5.7.6-7.5 1.6a5.1 5.1 0 0 0-2.7 4.7c0 1.3.5 2.4 1.5 3.3 1 1 2.3 1.4 4.1 1.4 2.5 0 4.5-1 6-2.7a9 9 0 0 0 2.5-6.4l-.1-1.7zm4.5 13.2h-4c-.2-.8-.4-2.4-.5-4.7a9.6 9.6 0 0 1-9.2 5.5c-3 0-5.2-.8-6.8-2.4a7.7 7.7 0 0 1-2.3-5.7 8 8 0 0 1 3.4-6.6c2.2-1.7 6-2.6 11.4-2.6l3.5.1c0-2-.2-3.6-.5-4.5a4 4 0 0 0-2-2.3c-1-.5-2.4-.8-4.1-.8-4.2 0-6.6 1.6-7.2 4.8l-3.8-.7c1-4.9 4.8-7.3 11.6-7.3 3.6 0 6.1.8 7.6 2.4 1.6 1.7 2.3 4.5 2.3 8.4v11.3c0 1.9.2 3.6.6 5.1zm282.3 0h-4v-26.4h3.5v6.2c1.3-3 2.5-4.8 3.8-5.7a6.9 6.9 0 0 1 3.9-1.3l1.6.1v4h-.8c-2.3 0-4.1.8-5.6 2.5s-2.3 3.9-2.4 6.7v14zm28-13.2-3.8-.1c-3.2 0-5.7.5-7.5 1.6a5.1 5.1 0 0 0-2.6 4.6c0 1.3.4 2.4 1.4 3.4s2.3 1.3 4.2 1.3c2.4 0 4.4-.9 6-2.7a9.2 9.2 0 0 0 2.4-6.3l-.1-1.8zm4.5 13.3h-4c-.2-.9-.3-2.5-.5-4.8-1.8 3.7-4.9 5.5-9.2 5.5-3 0-5.2-.8-6.7-2.4a7.7 7.7 0 0 1-2.4-5.6 8 8 0 0 1 3.4-6.6c2.2-1.8 6-2.6 11.4-2.6h3.5c0-2-.2-3.5-.5-4.5a4 4 0 0 0-2-2.2 8 8 0 0 0-4.1-.9c-4.1 0-6.5 1.6-7.2 4.8l-3.8-.6c1-5 4.8-7.3 11.6-7.3 3.6 0 6.2.8 7.7 2.4 1.5 1.6 2.2 4.4 2.2 8.4v11.2c0 1.9.2 3.6.6 5.2zm24 0h-3.8v-17c0-2.5-.6-4.2-1.6-5.2s-2.4-1.5-3.9-1.5c-2 0-3.8.8-5.2 2.5a10 10 0 0 0-2 6.6v14.6h-4.2v-26.5h3.8v4.9c2.1-3.8 4.9-5.6 8.3-5.6a8.2 8.2 0 0 1 7.8 4.9c.5 1.3.8 3.6.8 7v15.3zm22.4-16.3c0-2.3-.7-4.2-2.1-5.6a6.7 6.7 0 0 0-5-2 6 6 0 0 0-5 2.7 13 13 0 0 0-1.9 7.6c0 3.6.6 6.3 1.8 8.1a5.6 5.6 0 0 0 5 2.8c1.9 0 3.5-.8 5-2.4a8.2 8.2 0 0 0 2.2-5.7v-5.5zm4-19.5v35.8h-3.6v-4.6c-1.9 3.5-4.6 5.3-8.3 5.3a9 9 0 0 1-7.6-3.9c-2-2.6-3-5.9-3-9.9s1-7.4 3-10a9 9 0 0 1 7.8-4.1 9 9 0 0 1 7.7 4.3v-13h4zM50.1 193.9c0 2.5.5 4.3 1.6 5.5 1 1.2 2.4 1.7 4.1 1.7 1.7 0 3-.6 4.1-2 1.1-1.3 1.7-4 1.8-8 0-2.9-.5-5.1-1.5-6.7a4.7 4.7 0 0 0-4.2-2.3c-1.7 0-3.1.7-4.2 2a8.7 8.7 0 0 0-1.7 5.7v4zm0 11.8H44v-38.4h6.2v14.5a10 10 0 0 1 3.6-4.1 9 9 0 0 1 11.6 2.9c2 2.5 3 6.1 3 10.7 0 4.1-1 7.7-3 10.6-2 3-4.7 4.4-8.4 4.4-1.2 0-2.7-.2-4-.8-1.7-.8-2.8-2-2.8-2v2.2zm43.2-4.5c-2 0-3.5-.8-4.7-2.4A11.5 11.5 0 0 1 87 192c0-2.8.6-5 1.6-6.7 1.1-1.7 2.8-2.5 5-2.5s3.8.8 4.8 2.4c.6 1 1 2.2 1.3 3.6h-5.8L93 194h6.9c-.5 4.8-2.6 7.2-6.5 7.2zm19-12.4h-5.8a13 13 0 0 0-3.5-7.1c-2.4-2.6-5.6-4-9.5-4-4 0-7.3 1.4-9.7 4a14.6 14.6 0 0 0-3.7 10.2c0 3.8 1 7 3.3 10 2.2 3 5.5 4.4 9.7 4.4a13 13 0 0 0 13.5-12.3h5.8v-5.2z"/><path fill="#005f9f" fill-rule="nonzero" d="M127 200.8v4.9c-1.9.4-3.3.6-4.3.6-1.7 0-3.1-.3-4.3-1a6.6 6.6 0 0 1-2.7-2.8 14 14 0 0 1-.8-5.3v-14.4h-4.3v-4.9h4.7l.5-7.2 5.1-.5v7.7h5.5v4.9H121v13.5c0 1.8.3 3 1 3.6.6.6 1.8 1 3.5 1l1.6-.1zm45.3-5.3 5.3.5c-.7 3.5-2 6-4 7.8-2 1.6-4.4 2.5-7.2 2.5-3.7 0-6.7-1.4-8.7-4.2a17 17 0 0 1-3-10.3c0-4.2 1-7.6 3.3-10.4a11 11 0 0 1 9-4c5.9 0 9.4 3.1 10.6 9.5l-5.3.7c-.5-3.4-2.2-5.1-5-5.1-2.2 0-3.7.9-4.6 2.8-1 1.8-1.5 4-1.5 6.7 0 2.8.5 5 1.5 6.5s2.4 2.3 4.2 2.3c2.7 0 4.5-1.8 5.4-5.3zm30.5 10.2h-6.2v-18.1c0-2-.4-3.4-1.3-4.2a4 4 0 0 0-2.9-1.2c-1.7 0-3.2.7-4.4 2.1-1.2 1.5-1.8 3.8-1.8 7v14.4H180v-37.5h6.2v14.6c1.6-4 4.3-6 8.1-6 5.7 0 8.5 3.3 8.5 9.8v19.1zm26 0h-6.2v-17.3c0-1.9-.4-3.2-1.2-4.2a4 4 0 0 0-3-1.3c-1.7 0-3 .7-4.3 2.1-1.2 1.4-1.8 3.6-1.8 6.5v14.2H206V178h5.7v6.4c2-4.7 4.7-7 8.3-7a9 9 0 0 1 6.2 2.3c1.7 1.5 2.5 4.2 2.5 8.1v18zm8.8-17.2a8 8 0 0 1 2-5 5.7 5.7 0 0 1 4.2-1.8c1.8 0 3.2.7 4.4 2a7 7 0 0 1 1.8 4.8h-12.4zm18.8 3.3c0-4.2-1-7.7-3.2-10.4-2.1-2.7-5.1-4-9-4-4 0-7.2 1.3-9.6 4a15.5 15.5 0 0 0-3.5 10.5c0 4.4 1.2 7.9 3.5 10.5 2.3 2.6 5.4 3.9 9.2 3.9 3.2 0 5.8-.9 7.9-2.5 2.1-1.6 3.5-3.7 4.2-6.2l-5.6-.8c-1 3-3 4.5-6.2 4.5a6 6 0 0 1-6-4.2 14 14 0 0 1-.5-4.5h18.8v-.8zM71.1 180.7h6.2v25h-6.2zm6.4-5.8c0 1.8-1.5 3.3-3.3 3.3a3.3 3.3 0 0 1-3.2-3.3c0-1.8 1.4-3.3 3.2-3.3 1.8 0 3.3 1.5 3.3 3.3zm180.7 5.6h.4c.5 0 .9-.2.9-.7 0-.3-.2-.6-.9-.6h-.4v1.3zm0 2h-.6v-3.7h1c.6 0 1 0 1.2.2.2.2.3.4.3.8 0 .5-.3.7-.7.9.3 0 .5.3.6.9 0 .5.2.7.2.9h-.6l-.2-1c-.1-.4-.3-.6-.8-.6h-.4v1.6zm.6-4.7a2.7 2.7 0 0 0-2.7 2.8 2.7 2.7 0 0 0 2.7 2.7 2.7 2.7 0 0 0 2.8-2.7 2.7 2.7 0 0 0-2.8-2.8zm0-.5a3.2 3.2 0 0 1 3.2 3.3c0 1.8-1.4 3.2-3.2 3.2a3.2 3.2 0 0 1-3.3-3.2 3.2 3.2 0 0 1 3.3-3.3zm21.4 17.7c0 2.2.8 4 2.2 5.7a6.6 6.6 0 0 0 5 2.4c2.1 0 3.8-1 5-2.8a15 15 0 0 0 1.8-8 13 13 0 0 0-2-7.7 6 6 0 0 0-5-2.8c-1.8 0-3.5.7-4.9 2.1a7.5 7.5 0 0 0-2 5.6v5.5zm0-25v12.9a9 9 0 0 1 7.7-4.3 9 9 0 0 1 7.8 4c2 2.7 3 6 3 10.1 0 4-1 7.3-3 9.9a9 9 0 0 1-7.6 3.9c-3.7 0-6.4-1.8-8.3-5.3v4.6h-3.6V170h4zM134 188.5a8 8 0 0 1 2-5 5.7 5.7 0 0 1 4.3-1.8c1.7 0 3.2.7 4.4 2a7 7 0 0 1 1.7 4.8H134zm19 3.3c0-4.2-1.2-7.7-3.3-10.4-2.1-2.7-5.2-4-9-4a12 12 0 0 0-9.6 4 15.5 15.5 0 0 0-3.5 10.5c0 4.4 1.2 7.9 3.5 10.5 2.3 2.6 5.4 3.9 9.2 3.9 3.1 0 5.8-.9 7.9-2.5 2-1.6 3.5-3.7 4.2-6.2l-5.6-.8c-1 3-3.1 4.5-6.2 4.5a6 6 0 0 1-6-4.2c-.4-1.1-.6-2.6-.6-4.5h18.9v-.8z"/><path fill="#525860" fill-rule="nonzero" d="M395.4 102c.5 0 1.1-.2 1.1-.8 0-.5-.5-.7-1-.7h-.8v1.4h.7zm-1.6-2.3h1.7c1 0 1.9.4 1.9 1.5 0 .7-.4 1.2-1.2 1.4l1.4 2.2h-1.1l-1.2-2.1h-.6v2h-1v-5zm1.7 6.4a3.8 3.8 0 0 0 3.8-3.8 3.8 3.8 0 0 0-7.6 0 3.8 3.8 0 0 0 3.8 3.8zm0-8.3a4.5 4.5 0 0 1 4.5 4.5c0 2.5-2 4.4-4.5 4.4s-4.5-2-4.5-4.4a4.5 4.5 0 0 1 4.5-4.5z"/></svg> </a> <p class="adr"> <span class="street-address">2150 Woodward St., Suite 100</span> <br> <span class="locality">Austin</span>, <span class="region">TX</span> <span class="postal-code">78744</span> <span class="country-name">USA</span> </p> </div> </div> <div class="right"> <nav class="primary"> <a href="https://asuragen.com/portfolio/">Portfolio</a> <a href="https://asuragen.com/companion-diagnostics/">Companion Diagnostics</a> <a href="https://asuragen.com/enabling-technologies/">Enabling Technologies</a> <a href="https://asuragen.com/resources/">Resources</a> <a href="https://asuragen.com/spotlight/">Community</a> </nav> <div class="secondary"> <nav class="links"> <a href="https://asuragen.com/about/">About</a> <a href="https://asuragen.com/contact/">Contact</a> <a href="https://asuragen.com/careers/">Careers</a> </nav> <nav class="social"> <a href="https://www.linkedin.com/company/asuragen" target="_blank"><svg viewBox="0 0 800 800"><path d="M268 629h-97V319h97zm157 0h-97V319h93v42h1q31-50 93-50 114 0 114 133v185h-96V466q0-70-49-70-59 0-59 69z"/><circle cx="219" cy="220" r="56"/></svg></a> <a href="https://twitter.com/Asuragen" target="_blank"><svg viewBox="0 0 800 800"><path d="M679 239s-21 34-55 57c7 156-107 329-314 329-103 0-169-50-169-50s81 17 163-45c-83-5-103-77-103-77s23 6 50-2c-93-23-89-110-89-110s23 14 50 14c-84-65-34-148-34-148s76 107 228 116c-22-121 117-177 188-101 37-6 71-27 71-27s-12 41-49 61c30-2 63-17 63-17z"/></svg></a> <a href="https://www.facebook.com/Asuragen/" target="_blank"><svg viewBox="0 0 800 800"><path d="M445 643h-90V419h-75v-87h75v-64q0-55 32-86 30-29 80-29 28 0 67 3v78h-47q-42 0-42 38v60h86l-11 87h-75v224z"/></svg></a> <a href="https://www.youtube.com/channel/UCJvWl3pIBYGT2HBZfwuSvXg" target="_blank"><svg viewBox="0 0 800 800" xmlns="http://www.w3.org/2000/svg"> <path d="M400 224c144 0 201 2 224 25 17 17 26 52.125 26 151s-9 134-26 151c-23 23-80 25-224 25s-201-2-224-25c-17-17-26-52.125-26-151s9-134 26-151c23-23 80-25 224-25zm-52 100v141l135-70z"/> </svg></a> <a href="https://vimeo.com/asuragen" target="_blank"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24"><path d="M21.063,10.38 C19.028,14.728 14.115,20.646 11.01,20.646 C7.95,20.646 7.508,14.12 5.837,9.777 C5.015,7.639 4.484,8.13 2.942,9.209 L2.002,7.997 C4.25,6.02 6.5,3.724 7.883,3.597 C9.44,3.448 10.398,4.512 10.756,6.79 C11.23,9.784 11.891,14.432 13.046,14.432 C13.946,14.432 16.164,10.745 16.278,9.427 C16.48,7.497 14.859,7.438 13.451,8.041 C15.679,0.746 24.945,2.089 21.063,10.38 z" /></svg></a> </nav> </div> <p class="copy"> <span>© Copyright 2025 ASURAGEN, INC. An Equal Opportunity Employer. All Rights Reserved.</span> <span><a href="https://www.bio-techne.com/privacy-and-cookie-policy">Privacy Policy</a></span> <span><a href="https://asuragen.com/wp-content/uploads/2016/05/Asuragen-Website-Terms-and-Conditions-of-Use-15JUN15.pdf" target="_blank">Website Terms of Use</a></span> <span><a href="https://asuragen.com/fcoi/">Financial Conflict of Interest Policy</a></span> </p> </div> </div> </footer> <script>/*<![CDATA[*/(function(w,a,b,d,s){w[a]=w[a]||{};w[a][b]=w[a][b]||{q:[],track:function(r,e,t){this.q.push({r:r,e:e,t:t||+new Date});}};var e=d.createElement(s);var f=d.getElementsByTagName(s)[0];e.async=1;e.src='//info.asuragen.com/cdnr/69/acton/bn/tracker/11406';f.parentNode.insertBefore(e,f);})(window,'ActOn','Beacon',document,'script');ActOn.Beacon.track();/*]]>*/</script>   <script type="text/javascript"> /* <![CDATA[ */ var google_conversion_id = 971040246; var google_custom_params = window.google_tag_params; var google_remarketing_only = true; /* ]]> */ </script> <script type="text/javascript" src="https://www.googleadservices.com/pagead/conversion.js"> </script> <noscript> <div style="display:inline;"> <img height="1" width="1" style="border-style:none;" alt="" src="//googleads.g.doubleclick.net/pagead/viewthroughconversion/971040246/?value=0&guid=ON&script=0"/> </div> </noscript> <script defer src="https://asuragen.com/wp-content/cache/autoptimize/js/autoptimize_1f271ac3cf40e414ab649d4f18f12f5a.js"></script></body> </html>

CINXE.COM

AGG Interruption Testing | Xpansion Interpreter® | Asuragen