CINXE.COM

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id="main" class="site-main"> <article id="post-25756" class="post-25756 page type-page status-publish hentry"> <div class="entry-content"> <div id="block-block_f42a2e0acbf6e22ef7306092dc9d7222" class="block block--content block--full-width align--bg-right align--bg-mobile-left size--bg-full size--bg-mobile-default align--vertical-text-center align--text-left align--text-mobile-center fill fill--blue vertical-padding--none text-wrap--50" style="min-height: 415px; background-repeat:no-repeat;"> <div class="bg " style="background-image: url(https://www.adaptivebiotech.com/wp-content/uploads/2023/05/banner-hero-waves-2.png); min-height: 415px; background-repeat:no-repeat;"> <div class="container" style="min-height: 415px;"> <div class="acf-innerblocks-container"> <p>Drug Discovery</p> <h1 class="wp-block-heading has-white-color has-text-color" id="h-antibody-therapeutics">Antibody Therapeutics</h1> </div> </div> </div> </div> <div class="wp-block-group alignwide is-layout-constrained wp-block-group-is-layout-constrained"> <div style="height:60px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading has-navy-color has-text-color" id="h-identifying-antibodies-for-therapeutic-use">Identifying Antibodies for<br>Therapeutic Use</h2> <p>Adaptive’s high-throughput antibody discovery process enables rapid identification and selection of potent, naturally occurring, entirely human antibodies for clinical development and commercialization.</p> <div style="height:40px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-3 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:125px"> <figure class="wp-block-image size-full is-resized"><img decoding="async" width="125" height="125" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Two-tone-icon-Versatility-q49lps8mdapoa9azbt1fdmn5hx0bhv28yoz8pl5gyq.webp" alt="" class="wp-image-25757" style="width:125px;height:125px" title="Two-tone-icon–Versatility-"/></figure> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <h3 class="wp-block-heading has-blue-color has-text-color" id="h-versatility">Versatility</h3> <ul class="wp-block-list"> <li>Use B cells from human blood</li> <li>Sourced from humanized mice</li> </ul> </div> </div> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:125px"> <figure class="wp-block-image size-full"><img decoding="async" width="125" height="125" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Two-tone-icon-Safety-01-q49lps8mdapoa9azbt1fdmn5hx0bhv28yoz8pl5gyq.webp" alt="" class="wp-image-25758" title="Two-tone-icon–Safety-01"/></figure> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <h3 class="wp-block-heading has-blue-color has-text-color" id="h-safety">Safety</h3> <ul class="wp-block-list"> <li>De-risked for manufacturing and developability</li> <li>Likely favorable safety profile</li> </ul> </div> </div> </div> </div> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-6 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-4 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:125px"> <figure class="wp-block-image size-full"><img decoding="async" width="125" height="125" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Two-tone-icon-Selection-q49lps8mdapoa9azbt1fdmn5hx0bhv28yoz8pl5gyq.webp" alt="" class="wp-image-25759" title="Two-tone-icon–Selection"/></figure> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <h3 class="wp-block-heading has-blue-color has-text-color" id="h-high-throughput-high-sensitivity">High-throughput, high sensitivity</h3> <ul class="wp-block-list"> <li>Hundreds of thousands of antibodies at a time</li> <li>Select likely winners using bioinformatics</li> <li>Accurate BCR heavy/light pairs at unprecedented scale</li> <li>Screen for natural human antibodies</li> </ul> </div> </div> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-5 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:125px"> <figure class="wp-block-image size-full"><img loading="lazy" decoding="async" width="125" height="125" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Two-tone-icon-T-Cell-q49lps8mdapoa9azbt1fdmn5hx0bhv28yoz8pl5gyq.webp" alt="" class="wp-image-25760" title="Two-tone-icon–T-Cell"/></figure> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <h3 class="wp-block-heading has-blue-color has-text-color" id="h-best-clinical-candidate-selection">Best clinical candidate selection</h3> <ul class="wp-block-list"> <li>Entire B-cell receptors (BCR) repertoire interrogated</li> <li>Well-characterized, naturally optimized antibodies</li> <li>Support rational monoclonal antibody combinations</li> </ul> </div> </div> </div> </div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide"/> <div style="height:40px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading has-navy-color has-text-color" id="h-developing-therapeutic-antibodies-against-sars-cov-2">Developing Therapeutic<br>Antibodies Against SARS-CoV-2</h2> <p>Neutralizing antibodies defend healthy cells by blocking the biological function of an invading virus. </p> <p>Adaptive has identified and characterized ultra-potent, neutralizing antibodies that bind to different parts of the SARS-CoV-2 virus and can be considered for development to treat COVID-19.</p> <p>View <a href="https://www.sciencedirect.com/science/article/pii/S2451945623002398" target="_blank" rel="noreferrer noopener">Publications</a> for the article published in Cell Chemical Biology in 2023.</p> <div style="height:60px" aria-hidden="true" class="wp-block-spacer"></div> </div> </div> </article> </main> </div> </div> <div class="sub-footer" role="complementary"> <div class="container"> <div id="block-cta_footer" class="block block--cta fill 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