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<!DOCTYPE html> <html lang="en" itemid="https://www.nytimes.com/2019/06/07/health/drug-companies-antibiotics-resistance.html" itemtype="http://schema.org/NewsArticle" itemscope="" class="story" xmlns:og="http://opengraphprotocol.org/schema/"> <head><script type="text/javascript" src="/_static/js/bundle-playback.js?v=HxkREWBo" charset="utf-8"></script> <script type="text/javascript" src="/_static/js/wombat.js?v=txqj7nKC" charset="utf-8"></script> <script>window.RufflePlayer=window.RufflePlayer||{};window.RufflePlayer.config={"autoplay":"on","unmuteOverlay":"hidden"};</script> <script type="text/javascript" src="/_static/js/ruffle/ruffle.js"></script> <script type="text/javascript"> __wm.init("https://web.archive.org/web"); __wm.wombat("https://www.nytimes.com/2019/06/07/health/drug-companies-antibiotics-resistance.html","20190621100134","https://web.archive.org/","web","/_static/", "1561111294"); </script> <link rel="stylesheet" type="text/css" href="/_static/css/banner-styles.css?v=S1zqJCYt" /> <link rel="stylesheet" type="text/css" href="/_static/css/iconochive.css?v=3PDvdIFv" />  <title data-rh="true">Warning of ‘Pig Zero’: One Drugmaker’s Push to Sell More Antibiotics - The New York Times</title> <meta data-rh="true" itemprop="inLanguage" content="en-US"/><meta data-rh="true" property="article:published" itemprop="datePublished dateCreated" content="2019-06-07T14:59:38.000Z"/><meta data-rh="true" property="article:modified" itemprop="dateModified" content="2019-06-12T21:53:46.060Z"/><meta data-rh="true" http-equiv="Content-Language" content="en"/><meta data-rh="true" name="robots" content="noarchive"/><meta data-rh="true" name="articleid" itemprop="identifier" content="100000006523599"/><meta data-rh="true" name="nyt_uri" itemprop="identifier" content="nyt://article/28515c92-aa79-5019-b591-7c206597f332"/><meta data-rh="true" name="pubp_event_id" itemprop="identifier" content="pubp://event/4490c809f1fc4569b341ad91f3daddc3"/><meta data-rh="true" name="description" itemprop="description" content="Overuse of antibiotics in livestock has given rise to drug-resistant germs. Drugmakers say they want to be part of the solution. But a recent campaign urged farmers to administer the drugs to healthy animals daily."/><meta data-rh="true" name="image" itemprop="image" content="https://web.archive.org/web/20190621100134im_/https://static01.nyt.com/images/2019/06/06/science/00GERMS-ELANCO-promo2/00GERMS-ELANCO-promo2-facebookJumbo.jpg"/><meta data-rh="true" name="byl" content="By Danny Hakim and Matt Richtel"/><meta data-rh="true" name="thumbnail" itemprop="thumbnailUrl" content="https://web.archive.org/web/20190621100134im_/https://static01.nyt.com/images/2019/06/06/science/00GERMS-ELANCO-promo2/00GERMS-ELANCO-promo2-thumbStandard.jpg"/><meta data-rh="true" name="news_keywords" content="Antibacterial,Drug resistance,Pharmaceuticals,Livestock,Pig,Agriculture,Elanco,Jeffrey N. 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But a recent campaign urged farmers to administer the drugs to healthy animals daily."/><meta data-rh="true" property="twitter:url" content="https://www.nytimes.com/2019/06/07/health/drug-companies-antibiotics-resistance.html"/><meta data-rh="true" property="twitter:title" content="Warning of ‘Pig Zero’: One Drugmaker’s Push to Sell More Antibiotics"/><meta data-rh="true" property="twitter:description" content="Overuse of antibiotics in livestock has given rise to drug-resistant germs. Drugmakers say they want to be part of the solution. But a recent campaign urged farmers to administer the drugs to healthy animals daily."/><meta data-rh="true" property="twitter:image" content="https://static01.nyt.com/images/2019/06/06/science/00GERMS-ELANCO-promo2/00GERMS-ELANCO-promo2-videoSixteenByNineJumbo1600.jpg"/><meta data-rh="true" property="twitter:image:alt" content="A brochure by Elanco, one of the largest manufacturers of drugs for animals, urged farmers to give antibiotics to every pig in their herds."/><meta data-rh="true" property="twitter:card" content="summary_large_image"/><meta data-rh="true" property="article:section" itemprop="articleSection" content="Health"/><meta data-rh="true" property="article:tag" content="Antibiotics"/><meta data-rh="true" property="article:tag" content="Drug Resistance (Microbial)"/><meta data-rh="true" property="article:tag" content="Drugs (Pharmaceuticals)"/><meta data-rh="true" property="article:tag" content="Livestock"/><meta data-rh="true" property="article:tag" content="Pigs"/><meta 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translate(0px,5px);}100%{-webkit-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,10px);-ms-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,10px);transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,10px);}}@keyframes animation-1kjk1j2{0%{-webkit-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,10px);-ms-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,10px);transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,10px);}25%{-webkit-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,5px);-ms-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,5px);transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,5px);}50%{-webkit-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,0px);-ms-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,0px);transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,0px);}75%{-webkit-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,5px);-ms-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,5px);transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,5px);}100%{-webkit-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,10px);-ms-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,10px);transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,10px);}}@-webkit-keyframes animation-88g286{0%{-webkit-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);-ms-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);}25%{-webkit-transform:translate(34px,0px) translate(-34px,0px) translate(0px,10px);-ms-transform:translate(34px,0px) translate(-34px,0px) translate(0px,10px);transform:translate(34px,0px) translate(-34px,0px) translate(0px,10px);}50%{-webkit-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);-ms-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);}75%{-webkit-transform:translate(34px,0px) translate(-34px,0px) translate(0px,0px);-ms-transform:translate(34px,0px) translate(-34px,0px) translate(0px,0px);transform:translate(34px,0px) translate(-34px,0px) translate(0px,0px);}100%{-webkit-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);-ms-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);}}@keyframes animation-88g286{0%{-webkit-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);-ms-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);}25%{-webkit-transform:translate(34px,0px) translate(-34px,0px) translate(0px,10px);-ms-transform:translate(34px,0px) translate(-34px,0px) translate(0px,10px);transform:translate(34px,0px) translate(-34px,0px) translate(0px,10px);}50%{-webkit-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);-ms-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);}75%{-webkit-transform:translate(34px,0px) translate(-34px,0px) translate(0px,0px);-ms-transform:translate(34px,0px) translate(-34px,0px) translate(0px,0px);transform:translate(34px,0px) translate(-34px,0px) translate(0px,0px);}100%{-webkit-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);-ms-transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);transform:translate(34px,0px) translate(-34px,0px) translate(0px,5px);}}@-webkit-keyframes animation-12yx39b{0%{-webkit-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);-ms-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);}25%{-webkit-transform:translate(34px,0px) scale(1,0.9) translate(-34px,0px);-ms-transform:translate(34px,0px) scale(1,0.9) translate(-34px,0px);transform:translate(34px,0px) scale(1,0.9) translate(-34px,0px);}50%{-webkit-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);-ms-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);}75%{-webkit-transform:translate(34px,0px) scale(1,1) translate(-34px,0px);-ms-transform:translate(34px,0px) scale(1,1) translate(-34px,0px);transform:translate(34px,0px) scale(1,1) translate(-34px,0px);}100%{-webkit-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);-ms-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);}}@keyframes animation-12yx39b{0%{-webkit-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);-ms-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);}25%{-webkit-transform:translate(34px,0px) scale(1,0.9) translate(-34px,0px);-ms-transform:translate(34px,0px) scale(1,0.9) translate(-34px,0px);transform:translate(34px,0px) scale(1,0.9) translate(-34px,0px);}50%{-webkit-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);-ms-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);}75%{-webkit-transform:translate(34px,0px) scale(1,1) translate(-34px,0px);-ms-transform:translate(34px,0px) scale(1,1) translate(-34px,0px);transform:translate(34px,0px) scale(1,1) translate(-34px,0px);}100%{-webkit-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);-ms-transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);transform:translate(34px,0px) scale(1,0.95) translate(-34px,0px);}}@-webkit-keyframes animation-4hu8jm{0%{-webkit-transform:translate(0px,0px) scale(1,0.85) translate(0px,0px);-ms-transform:translate(0px,0px) scale(1,0.85) translate(0px,0px);transform:translate(0px,0px) scale(1,0.85) translate(0px,0px);}33.33%{-webkit-transform:translate(0px,0px) scale(1,0.9) translate(0px,0px);-ms-transform:translate(0px,0px) scale(1,0.9) translate(0px,0px);transform:translate(0px,0px) scale(1,0.9) translate(0px,0px);}100%{-webkit-transform:translate(0px,0px) scale(1,0.1) translate(0px,0px);-ms-transform:translate(0px,0px) scale(1,0.1) translate(0px,0px);transform:translate(0px,0px) scale(1,0.1) translate(0px,0px);}}@keyframes animation-4hu8jm{0%{-webkit-transform:translate(0px,0px) scale(1,0.85) translate(0px,0px);-ms-transform:translate(0px,0px) scale(1,0.85) translate(0px,0px);transform:translate(0px,0px) scale(1,0.85) translate(0px,0px);}33.33%{-webkit-transform:translate(0px,0px) scale(1,0.9) translate(0px,0px);-ms-transform:translate(0px,0px) scale(1,0.9) translate(0px,0px);transform:translate(0px,0px) scale(1,0.9) translate(0px,0px);}100%{-webkit-transform:translate(0px,0px) scale(1,0.1) translate(0px,0px);-ms-transform:translate(0px,0px) scale(1,0.1) translate(0px,0px);transform:translate(0px,0px) scale(1,0.1) translate(0px,0px);}}@-webkit-keyframes animation-1wqz2f4{0%{-webkit-transform:translate(0px,0px) translate(0px,0px) translate(0px,15px);-ms-transform:translate(0px,0px) translate(0px,0px) translate(0px,15px);transform:translate(0px,0px) translate(0px,0px) translate(0px,15px);}33.33%{-webkit-transform:translate(0px,0px) translate(0px,0px) translate(0px,10px);-ms-transform:translate(0px,0px) translate(0px,0px) translate(0px,10px);transform:translate(0px,0px) translate(0px,0px) translate(0px,10px);}100%{-webkit-transform:translate(0px,0px) translate(0px,0px) translate(0px,30px);-ms-transform:translate(0px,0px) translate(0px,0px) translate(0px,30px);transform:translate(0px,0px) translate(0px,0px) translate(0px,30px);}}@keyframes animation-1wqz2f4{0%{-webkit-transform:translate(0px,0px) translate(0px,0px) translate(0px,15px);-ms-transform:translate(0px,0px) translate(0px,0px) translate(0px,15px);transform:translate(0px,0px) translate(0px,0px) translate(0px,15px);}33.33%{-webkit-transform:translate(0px,0px) translate(0px,0px) translate(0px,10px);-ms-transform:translate(0px,0px) translate(0px,0px) translate(0px,10px);transform:translate(0px,0px) translate(0px,0px) translate(0px,10px);}100%{-webkit-transform:translate(0px,0px) translate(0px,0px) translate(0px,30px);-ms-transform:translate(0px,0px) translate(0px,0px) translate(0px,30px);transform:translate(0px,0px) translate(0px,0px) translate(0px,30px);}}@-webkit-keyframes animation-yl3z84{0%{-webkit-transform:translate(11.329999923706055px,0px) scale(1,0.85) translate(-11.329999923706055px,0px);-ms-transform:translate(11.329999923706055px,0px) scale(1,0.85) translate(-11.329999923706055px,0px);transform:translate(11.329999923706055px,0px) scale(1,0.85) translate(-11.329999923706055px,0px);}33.33%{-webkit-transform:translate(11.329999923706055px,0px) scale(1,0.9) translate(-11.329999923706055px,0px);-ms-transform:translate(11.329999923706055px,0px) scale(1,0.9) translate(-11.329999923706055px,0px);transform:translate(11.329999923706055px,0px) scale(1,0.9) translate(-11.329999923706055px,0px);}100%{-webkit-transform:translate(11.329999923706055px,0px) scale(1,0.1) translate(-11.329999923706055px,0px);-ms-transform:translate(11.329999923706055px,0px) scale(1,0.1) translate(-11.329999923706055px,0px);transform:translate(11.329999923706055px,0px) scale(1,0.1) translate(-11.329999923706055px,0px);}}@keyframes animation-yl3z84{0%{-webkit-transform:translate(11.329999923706055px,0px) scale(1,0.85) translate(-11.329999923706055px,0px);-ms-transform:translate(11.329999923706055px,0px) scale(1,0.85) translate(-11.329999923706055px,0px);transform:translate(11.329999923706055px,0px) scale(1,0.85) translate(-11.329999923706055px,0px);}33.33%{-webkit-transform:translate(11.329999923706055px,0px) scale(1,0.9) translate(-11.329999923706055px,0px);-ms-transform:translate(11.329999923706055px,0px) scale(1,0.9) translate(-11.329999923706055px,0px);transform:translate(11.329999923706055px,0px) scale(1,0.9) translate(-11.329999923706055px,0px);}100%{-webkit-transform:translate(11.329999923706055px,0px) scale(1,0.1) translate(-11.329999923706055px,0px);-ms-transform:translate(11.329999923706055px,0px) scale(1,0.1) translate(-11.329999923706055px,0px);transform:translate(11.329999923706055px,0px) scale(1,0.1) translate(-11.329999923706055px,0px);}}@-webkit-keyframes animation-1q3gjvc{0%{-webkit-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,15px);-ms-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,15px);transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,15px);}33.33%{-webkit-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,10px);-ms-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,10px);transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,10px);}100%{-webkit-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,30px);-ms-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,30px);transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,30px);}}@keyframes animation-1q3gjvc{0%{-webkit-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,15px);-ms-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,15px);transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,15px);}33.33%{-webkit-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,10px);-ms-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,10px);transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,10px);}100%{-webkit-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,30px);-ms-transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,30px);transform:translate(11.329999923706055px,0px) translate(-11.329999923706055px,0px) translate(0px,30px);}}@-webkit-keyframes animation-nc39ev{0%{-webkit-transform:translate(22.670000076293945px,0px) scale(1,0.85) translate(-22.670000076293945px,0px);-ms-transform:translate(22.670000076293945px,0px) scale(1,0.85) translate(-22.670000076293945px,0px);transform:translate(22.670000076293945px,0px) scale(1,0.85) translate(-22.670000076293945px,0px);}33.33%{-webkit-transform:translate(22.670000076293945px,0px) scale(1,0.9) translate(-22.670000076293945px,0px);-ms-transform:translate(22.670000076293945px,0px) scale(1,0.9) translate(-22.670000076293945px,0px);transform:translate(22.670000076293945px,0px) scale(1,0.9) translate(-22.670000076293945px,0px);}100%{-webkit-transform:translate(22.670000076293945px,0px) scale(1,0.1) translate(-22.670000076293945px,0px);-ms-transform:translate(22.670000076293945px,0px) scale(1,0.1) translate(-22.670000076293945px,0px);transform:translate(22.670000076293945px,0px) scale(1,0.1) translate(-22.670000076293945px,0px);}}@keyframes animation-nc39ev{0%{-webkit-transform:translate(22.670000076293945px,0px) scale(1,0.85) translate(-22.670000076293945px,0px);-ms-transform:translate(22.670000076293945px,0px) scale(1,0.85) translate(-22.670000076293945px,0px);transform:translate(22.670000076293945px,0px) scale(1,0.85) translate(-22.670000076293945px,0px);}33.33%{-webkit-transform:translate(22.670000076293945px,0px) scale(1,0.9) translate(-22.670000076293945px,0px);-ms-transform:translate(22.670000076293945px,0px) scale(1,0.9) translate(-22.670000076293945px,0px);transform:translate(22.670000076293945px,0px) scale(1,0.9) translate(-22.670000076293945px,0px);}100%{-webkit-transform:translate(22.670000076293945px,0px) scale(1,0.1) translate(-22.670000076293945px,0px);-ms-transform:translate(22.670000076293945px,0px) scale(1,0.1) translate(-22.670000076293945px,0px);transform:translate(22.670000076293945px,0px) scale(1,0.1) translate(-22.670000076293945px,0px);}}@-webkit-keyframes animation-amd09y{0%{-webkit-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,15px);-ms-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,15px);transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,15px);}33.33%{-webkit-transform:translate(22.670000076293945px,0px) translate(-22.670000076293945px,0px) translate(0px,10px);-ms-transform:translate(22.670000076293945px,0px) 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r="4"></circle></svg></button></div></div></section></header></div><p class="css-15x8ju0 e6idgb70">Deadly Germs, Lost Cures</p><div class="css-1sojcmr ehdk2mb0"><h1 itemprop="headline" class="css-w61oyk e1h9rw200" id="link-659ba08c"><span>Warning of ‘Pig Zero’: One Drugmaker’s Push to Sell More Antibiotics</span></h1></div><p class="css-1npvhc5 e1wiw3jv0">Overuse of antibiotics in livestock has given rise to drug-resistant germs. Drugmakers say they want to be part of the solution. But a recent campaign urged farmers to administer the drugs to healthy animals daily.</p></div></div></header><div class="css-nwzfg5 e1xwzt920"><p class="css-14xmeol"><span class="css-1f9pvn2 health">A brochure by Elanco, one of the largest manufacturers of drugs for animals, urged farmers to give antibiotics to every pig in their herds, even as it told the public and policymakers it was aware of the hazards that the overuse of antibiotics poses to human health.</span><span itemprop="copyrightHolder" class="emkp2hg2 css-1nwzsjy e1z0qqy90"><span class="css-1ly73wi e1tej78p0">Credit</span><span><span class="css-1dv1kvn">Credit</span><span> </span></span></span></p></div><div id="sponsor-wrapper" class="css-1hyfx7x"><div id="sponsor-slug" class="css-19vbshk"><p>Supported by</p></div><div class="ad sponsor-wrapper" style="text-align:center;height:100%;display:block"><div id="sponsor" class="" data-position="sponsor"></div></div></div><div class="css-tdubhs e1xwzt921"><div class="css-acwcvw epjyd6m0"><div class="css-vp77d3 epjyd6m1"><div class="css-1baulvz"><p class="css-16vrk19 e1jsehar1" itemprop="author" itemscope="" itemtype="http://schema.org/Person">By <a href="https://web.archive.org/web/20190621100134/https://www.nytimes.com/by/danny-hakim" class="css-1riqqik e1jsehar0"><span class="css-1baulvz" itemprop="name">Danny Hakim</span></a> and <a href="https://web.archive.org/web/20190621100134/https://www.nytimes.com/by/matt-richtel" class="css-1riqqik e1jsehar0"><span class="css-1baulvz" itemprop="name">Matt Richtel</span></a></p></div></div><ul class="css-1w5cs23 epjyd6m2"><li><time class="css-rs1psd e16638kd0" datetime="2019-06-07">June 7, 2019</time></li><li class="css-6n7j50"><div class=""><div role="toolbar" aria-label="Social Media Share buttons, Save button, and Comments Panel with current comment count" class="css-d8bdto" data-testid="share-tools"><ul class="css-y8aj3r"><li class="css-60hakz"><a 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0v8.418zM7.407 6.539l-1.13-1.137L.907 9h13l-5.37-3.598-1.13 1.137zM1.297 0h12.22l-6.11 5.095L1.297 0z" fill="#000"></path></svg></a></li><li class="css-60hakz"><div class="css-6n7j50"><button aria-haspopup="true" aria-expanded="false" aria-label="More sharing options" class="css-16ogagc" data-testid=""><svg class="css-uhuo44" viewbox="0 0 16 13" width="16" height="13"><path fill-rule="evenodd" clip-rule="evenodd" d="M15.406 5.359L8.978 0v3.215C3.82 3.215.406 8.107.406 12.66 1.653 9.133 4.29 7.517 8.978 7.517v3.2l6.428-5.358z" fill="#000"></path></svg></button></div></li><li class="css-60hakz"></li><li class="css-l72opv"></li></ul></div></div></li></ul></div></div></div><section name="articleBody" itemprop="articleBody" class="meteredContent css-1i2y565"><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">Facing a surge in drug-resistant infections, the World Health Organization issued <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.who.int/news-room/detail/07-11-2017-stop-using-antibiotics-in-healthy-animals-to-prevent-the-spread-of-antibiotic-resistance" title="" rel="noopener noreferrer" target="_blank">a plea to farmers</a> two years ago: “Stop using antibiotics in healthy animals.” </p><p class="css-exrw3m evys1bk0">But at last year’s big swine industry trade show, the World Pork Expo in Des Moines, one of the largest manufacturers of drugs for livestock was pushing the opposite message. </p><p class="css-exrw3m evys1bk0">“Don’t wait for Pig Zero,” warned a poster featuring a giant picture of a pig peeking through an enormous blue zero, at a booth run by the drugmaker Elanco.</p><p class="css-exrw3m evys1bk0">The company’s <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.documentcloud.org/documents/6140032-Pig-Zero-Combined-4.html" title="" rel="noopener noreferrer" target="_blank">Pig Zero brochures</a> encouraged farmers to give antibiotics to every pig in their herds rather than waiting to treat a disease outbreak caused by an unknown <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.imdb.com/title/tt3458254/" title="" rel="noopener noreferrer" target="_blank">Patient Zero</a>. It was an appealing pitch for industrial farms, where crowded, germ-prone conditions have led to increasing reliance on drug interventions. The pamphlets also detailed how feeding pigs a daily regimen of two antibiotics would make them fatter and, as any farmer understands, a heavier pig is a more profitable pig. </p></div><aside class="css-o6xoe7"></aside></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">The rise of drug-resistant germs, caused by overuse of antibiotics, is one of the world’s most nettlesome health predicaments. Excessive use of the medicines has allowed germs to develop defenses against them, rendering a growing number of drugs ineffective for people and animals. The practices of livestock farmers, who for decades have used huge quantities of the drugs deemed important to humans, have long been viewed as one of the roots of the problem, but the role of the companies that make the drugs has received less scrutiny.</p><p class="css-exrw3m evys1bk0">Antibiotics continue to be an important part of the business of companies like Elanco, which spun off from Eli Lilly in September, its share price soaring to $33 from $24. While Elanco is developing antibiotic alternatives for animals, like vaccines and enzymes, the antibiotics promoted by the Pig Zero campaign are exactly the kinds that global public health officials are trying to curb. And Elanco is no outlier — its rivals are also urging aggressive use of <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://web.archive.org/web/20190604015203/https://www.zoetisus.com/products/beef/bovatec.aspx?_ga=2.127535694.216929652.1537192460-1078237251.1536078211" title="" rel="noopener noreferrer" target="_blank">their own antibiotic cocktails</a>. </p><p class="css-exrw3m evys1bk0">“The reality is that antibiotics and large-scale industrial farming really grew up together,” said Dr. Gail Hansen, a former state epidemiologist and state public health veterinarian in Kansas, who sits on advisory boards addressing antibiotic resistance. She equated the problem with climate change. “By the time people understand and believe it,” Dr. Hansen said, “it may be too late.”</p><p class="css-exrw3m evys1bk0">Elanco had already been put on notice about the drugs used in its Pig Zero push. In 2015, the Food and Drug Administration warned Novartis Animal Health, which had been acquired by Elanco, that the same antibiotic cocktail was “unsafe” and “misbranded,” because it was being illegally marketed to fatten pigs, rather than to simply treat disease. One of the drugs, tiamulin, has been a top seller for Elanco; the W.H.O. views it as medically important to humans, but American regulators do not. Pig Zero trumpets the benefits of coupling tiamulin with chlortetracycline, a drug made by Elanco’s competitors that both American and international regulators consider <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/http://www.who.int/foodsafety/publications/cia2017.pdf?ua=1" title="" rel="noopener noreferrer" target="_blank">medically important</a> to humans. </p><p class="css-exrw3m evys1bk0">In an interview at Elanco’s headquarters outside Indianapolis, Jeffrey Simmons, the chief executive, said the company had decided to change the program’s marketing and to stop distributing the Pig Zero brochure after The New York Times began asking questions about it. </p></div><aside class="css-o6xoe7"></aside></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">“We’re trying to be stewards and leaders at the same time,” said Mr. Simmons, adding that the brochure “wasn’t misrepresentation, necessarily, relative to the label or the science, or how a farmer would look at it.”</p><p class="css-exrw3m evys1bk0">Dr. Shabbir Simjee, Elanco’s chief medical officer, said drugs like those in the campaign “would never be administered” in a herd “without some animals being physically sick,” adding that “there would need to be some animals showing clinical signs.”</p><p class="css-exrw3m evys1bk0">He likened treating a herd to caring for children in a nursery: “If one child gets sniffles, you usually find that the whole class ends up with a cold, and this is exactly the same principle.”</p><p class="css-exrw3m evys1bk0">But children almost certainly would not all be treated with preventive antibiotics in such a situation, and many scientists believe animals often should not be treated that way, either.</p><p class="css-exrw3m evys1bk0">The connection of overuse of antibiotics in livestock to human health takes two paths: As bacteria develop defenses against drugs widely used in animals, those defense mechanisms can spread to other bacteria that infect humans; and, resistant germs are transmitted from livestock to humans — through undercooked meat, farm-animal feces seeping into waterways, waste lagoons that overflow after natural disasters like <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.nytimes.com/2018/09/19/climate/florence-hog-farms.html?module=inline" title="">Hurricane Florence</a>, or when farm workers and others come into <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://oem.bmj.com/content/72/2/90" title="" rel="noopener noreferrer" target="_blank">contact with animals</a>.</p><p class="css-exrw3m evys1bk0">[Read other articles in our series <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.nytimes.com/series/deadly-germs-lost-cures?module=inline" title="">Deadly Germs, Lost Cures</a>.]</p></div><aside class="css-o6xoe7"></aside></div><figure class="sizeLarge css-qhlm6o" aria-label="media" role="group" itemscope="" itemprop="associatedMedia" itemtype="http://schema.org/VideoObject"><meta itemprop="transcript" content="There once was a man named Albert Alexander. He was a policeman — “[American accent] Hey.” — in England. “[British accent] Hello.” One day on patrol, he cut his cheek — “Ouch!” — which led to a terrible infection. See, this was back in 1941, before patients had antibiotics. These were the days when a little scratch could kill you. “Or you got an ear infection and you died. A cat bite and you died. Or you stepped on a stick and you died. All of a sudden, antibiotics come along and bang.” The antibiotic era had begun. Soon a slow and painful death became a seven-day course of antibiotics and a $10 copay. And Albert? Albert was the first patient in the world to receive the antibiotic — penicillin. And it worked. “We just came up with a lifesaving, life-extending drug, one of the greatest developments in human history. Except not.” That’s Matt Richtel, a science reporter for The New York Times. For the past year, Matt’s been talking to health experts to find out if we are reaching the end of the antibiotic era. Modern medicine depends on the antibiotic. “And having used it so much, we’re now putting it at risk. Is our fate sealed?” “First off, I don’t think people respect bacteria enough.” This is Ellen Silbergeld, one of the leading scientists studying antibiotic resistance. “Bacteria rule the world. We are just a platform for bacteria. Within the human body, there are more bacterial cells than there are human cells. So we are, in fact, mostly bacteria.” “Alexander Fleming —” the man who discovered penicillin “— in his Nobel speech said, hang on, be aware. When you start killing this stuff off, it’s going to fight back.” “Did we pay any attention to that? No.” “The C.D.C. got our attention today with a warning about what it calls ‘nightmare bacteria.’” “These are bacteria that are resistant to most, if not all, antibiotics.” When we take antibiotics to kill infections, some bacteria survive. It used to be they’d replicate, and eventually resistance would grow. But now, they’re way more efficient and share drug-resistant genes among themselves. So every time we take an antibiotic, we risk creating stronger, more resistant bacteria. And stronger, more resistant bacteria means less and less effective antibiotics. And this is a problem because we take lots of antibiotics. “Money gets made over the sale of antibiotics.” Big money. Globally, the antibiotics market is valued at $40 billion. And in the U.S., the C.D.C. estimates that about 30 percent of all prescribed antibiotics are not needed at all. That’s 47 million excess prescriptions. And in many places outside of the U.S., you don’t even need a prescription. “You can walk into a pharmacy. A pharmacist will diagnose you and give you antibiotics. I tend to think of it as a story of Darwinian forces multiplied by the pace and scale of global capitalism. In an interconnected world — travel, import, export — we’re moving the bugs with us.” “I can go to a meeting in China or Vietnam or some place —” This is Lance Price, the director of the Antibiotic Resistance Action Center. “I can become colonized by untreatable E. coli. And I might not have any symptoms. But you can get colonized. And you can become this sort of long-term host.” So you could be healthy and still spreading bad bacteria without even knowing it. “Drug-resistant bacteria have never been able to travel the world as fast as they do today.” And that’s just part of the problem. “You should know that about 80 percent of antibiotic production in this country goes into agriculture.” “Why on earth did somebody think putting antibiotics in agriculture was a great idea?” “We’ve said, hey, look, cram these animals together. Don’t worry too much about hygiene or trying to keep them healthy. Just give them antibiotics. And then in a couple weeks, you’re going to have full-grown animals that you can chop up and eat. Right? And you can make money off of that.” “Nobody was making the connection between feeding animals antibiotics and the fact that the food would be carrying drug-resistant bacteria.” So Ellen did a study. She compared different kinds of store-bought chicken. And she found that poultry raised with antibiotics had nine times as much drug-resistant bacteria on it. “Now, let’s talk about the vegetarians. I just want you to understand, you’re not safe. You know all these outbreaks that take place among the lettuce and the things like that. Have you ever wondered how that happened? It’s because animal manure is used in raising crops. Organic agriculture lauds the use of animal manure.” “Unless you’re just a complete, ‘I’m a vegan, and I only hang out with vegans, and I eat sterilized vegetables,’ you know, it’s very likely that you’re picking up the same bacteria.” Resistant bacteria seep into the groundwater, fly off the back of livestock trucks and hitch a ride home on the hands of farm workers, all of which makes trying to pinpoint exactly where resistant bacteria is originating extremely difficult. And even when it seems like there is a clear source, things still aren’t so simple. “No one wants to be seen as a hub of an epidemic.” Say your grandmother makes you a rump roast. And then that rump roast makes you sick. Well, if you live in France, or Ireland, or pretty much anywhere in the E.U., packaged meat has a tracking label. You can figure out exactly what farm that meat came from. But in the U.S., not even the top public health officials can do that. “Most countries have animal ID laws. We don’t.” Pat Basu, former chief veterinarian for the U.S.D.A.’s Food Safety and Inspection Service, basically one of the top veterinarians in the country. “Let me start at the beginning. We got a case where we had resistant bacteria causing illness in people. There were sick people that C.D.C. identified.” “More than 50 people in eight counties have gotten an unusual strain of salmonella linked to pork.” “This is not your grandmother’s pathogen anymore. This is a new bug.” Health officials traced the outbreak back to the slaughterhouse and identified six potential farms where the outbreak could have come from. But then the investigation shut down. “The individual farmers have to agree voluntarily to share the data with these investigators who go out. We couldn’t go any further back. It was a dead end.” 192 people sick, 30 hospitalizations and zero access for health officials to investigate the farms. “The secrecy is maintained because there are big economic forces behind it. Farms are scared of losing their ability to get antibiotics. Hospitals are scared of driving away patients.” “Well, as a physician, I do get very upset. I get very upset, as a patient, that information is being withheld.” This is Kevin Kavanagh, a doctor and a consumer advocate for patients. “Drug-resistant bacteria is a huge problem. If it occurs at a restaurant, if it occurs in a cruise ship, you know about this immediately —” “A salmonella outbreak —” “within days or hours of an outbreak occurring.” “This morning, Chipotle is keeping dozens of its restaurants in the Pacific Northwest closed —” “But yet, in a hospital, it can take you months or even over a year until this data appears on a governmental website or reported by the C.D.C.” In the U.S., hospitals are under no obligation to inform the public when a bacterial outbreak occurs. “Defend and deny. They are very concerned about the short-term economic benefits, rather than looking at long-term problems.” “There’s always this response like, well, but there’s still a drug, right? Like, this isn’t the end.” Remember Albert Alexander? — “Hello. Ouch!” — the first patient to be given penicillin? Well, his story didn’t end there. Five days after he started recovering, the hospital ran out of the new drug, and Mr. Alexander died. Today, we don’t have to worry about antibiotics running out. We have to worry about using them so much that they stop working altogether. “— want to know why a metro health department didn’t shut down a restaurant —” “It’s a very resistant bacteria —” “We really need to change the way we use antibiotics. Because the way we use antibiotics is destroying them.” “It’s putting at risk the entire system of care that we depend on for lengthening our lives and improving the quality of our lives.” The British government commissioned a study which predicted a worst case scenario where more people will die by 2050 of these infections than will die of cancer. “That’s a generation from now.” “It takes 10 years to identify, develop, test and bring to market a new antibiotic. And it takes a billion dollars.” “This is a common issue for humanity.” “Very similar to global warming.” “You can’t control it as a single company. You can’t control this as a single government.” And because the bacteria are now working together so efficiently — “Unless the world acts consistently together, it doesn’t make a difference.”"/><div class="css-bsn42l"><span class="css-1dv1kvn">Video</span><div><div class="css-1t0v8sy etkm6pg0"><div class="css-mm3pwi"></div><div class="css-1a74oa6 etkm6pg1"><div class="css-1ihorw etkm6pg2"><img src="https://web.archive.org/web/20190621100134im_/https://static01.nyt.com/images/2019/04/10/science/06GERMS-CANDIDA/dt_thumb_00000-videoSixteenByNineJumbo1600.jpg" alt="Video player loading"/></div><div class="css-1ruigs3"><div class="css-v15h5m"><div></div><div></div></div></div></div></div></div></div><figcaption itemprop="caption description name" class="css-17ai7jg emkp2hg0"><span class="css-8i9d0s e13ogyst0">Bacteria are rebelling. They’re turning the tide against antibiotics by outsmarting our wonder drugs. This video explores the surprising reasons.</span></figcaption></figure><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">New F.D.A. regulations put in effect in the waning days of the Obama administration prohibited farms from fattening livestock by lacing their feed with medically important antibiotics. The new rules, along with rising consumer demand for antibiotic-free meat, cut antibiotic use significantly in 2017. But such drugs are still routinely given to pigs <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.nytimes.com/2018/03/23/business/cattle-antiobiotics.html?module=inline" title="">and cattle</a>, accounting for almost 80 percent of medically important livestock antibiotics in the United States and nearly 5,000 tons of active ingredient. Worldwide use is projected to keep rising sharply as growing middle classes in places like China and Brazil demand more meat.</p></div><aside class="css-o6xoe7"></aside></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">Ellen Silbergeld, a professor at Johns Hopkins University, who has worked with the W.H.O. on drug resistance, called the continuing promotion of the drugs by pharmaceutical companies “very dangerous.”</p><p class="css-exrw3m evys1bk0">“The reason they’re doing it, though, is money, honey,” she added. “That’s what it’s all about. That’s what it’s always been about.”</p><p class="css-exrw3m evys1bk0">Now, the industry has an important ally in Washington: President Trump, who appointed one of Elanco’s former executives, Ted McKinney, as under secretary of agriculture for trade and foreign agricultural affairs. Mr. McKinney told international food safety regulators at a meeting last summer in Rome that they were too singularly focused on consumers, at the expense of pharmaceutical companies and research scientists working to meet growing global demand for food. “We have got to rededicate a focus on them as our customers,” he said.</p><h2 class="css-ani50b eoo0vm40" id="link-464baddb">‘Purpose-driven leader’</h2></div><aside class="css-o6xoe7"></aside></div><div class="css-79elbk" data-testid="photoviewer-wrapper"><div class="css-z3e15g" data-testid="photoviewer-wrapper-hidden"></div><div data-testid="photoviewer-children" class="css-1a48zt4 ehw59r15"><figure class="css-1ef8w8q e1g7ppur0" aria-label="media" role="group" itemprop="associatedMedia" itemscope="" itemid="https://static01.nyt.com/images/2019/02/01/science/00ELANCO-simmons/merlin_147683472_2f542857-90ba-4e3e-9959-fd235d13e88d-articleLarge.jpg?quality=90&auto=webp" itemtype="http://schema.org/ImageObject"><div class="css-1xdhyk6 erfvjey0"><span class="css-1ly73wi e1tej78p0">Image</span><img alt="“We’re trying to be stewards and leaders at the same time,” Jeffrey Simmons, Elanco’s chief executive, said." class="css-1m50asq" src="https://web.archive.org/web/20190621100134im_/https://static01.nyt.com/images/2019/02/01/science/00ELANCO-simmons/merlin_147683472_2f542857-90ba-4e3e-9959-fd235d13e88d-articleLarge.jpg?quality=75&auto=webp&disable=upscale" srcset="https://web.archive.org/web/20190621100134im_/https://static01.nyt.com/images/2019/02/01/science/00ELANCO-simmons/merlin_147683472_2f542857-90ba-4e3e-9959-fd235d13e88d-articleLarge.jpg?quality=90&auto=webp 600w, https://web.archive.org/web/20190621100134im_/https://static01.nyt.com/images/2019/02/01/science/00ELANCO-simmons/merlin_147683472_2f542857-90ba-4e3e-9959-fd235d13e88d-jumbo.jpg?quality=90&auto=webp 1024w, https://web.archive.org/web/20190621100134im_/https://static01.nyt.com/images/2019/02/01/science/00ELANCO-simmons/merlin_147683472_2f542857-90ba-4e3e-9959-fd235d13e88d-superJumbo.jpg?quality=90&auto=webp 2048w" sizes="((min-width: 600px) and (max-width: 1004px)) 84vw, (min-width: 1005px) 80vw, 100vw" itemprop="url" itemid="https://static01.nyt.com/images/2019/02/01/science/00ELANCO-simmons/merlin_147683472_2f542857-90ba-4e3e-9959-fd235d13e88d-articleLarge.jpg?quality=75&auto=webp&disable=upscale"/></div><figcaption itemprop="caption description" class="css-18crmh6 e1xdpqjp0"><span aria-hidden="true" class="css-8i9d0s e13ogyst0">“We’re trying to be stewards and leaders at the same time,” Jeffrey Simmons, Elanco’s chief executive, said.</span><span itemprop="copyrightHolder" class="css-vuqh7u e1z0qqy90"><span class="css-1ly73wi e1tej78p0">Credit</span><span>Whitten Sabbatini for The New York Times</span></span></figcaption></figure></div></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">In 2015, Mr. Simmons, Elanco’s chief executive, joined a White House summit meeting to pledge the company’s commitment to curbing antibiotic use.</p><p class="css-exrw3m evys1bk0">Sylvia M. Burwell, then the health and human services secretary, hailed the gathering as a “hopefully historic step to protect the health of our nation.” Dr. Thomas R. Frieden, the director of the Centers for Disease Control and Prevention at the time, warned that antibiotic resistance “could result in the medicine chest being empty when we need it most.”</p><p class="css-exrw3m evys1bk0">Mr. Simmons outlined Elanco’s lofty aims. “We’re going to create antibiotic alternatives,” he said, adding, “We believe strongly that there are solutions, there are pipelines, there are options.”</p></div><aside class="css-o6xoe7"></aside></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">A farm boy from upstate New York, he was a nearly 30-year veteran of Eli Lilly when Elanco spun off last year with its 5,800 employees. His wife helps run a church food bank. Mr. Simmons sits in an unassuming cubicle on Elanco’s campus.</p><p class="css-exrw3m evys1bk0">He refers to himself as a “<a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.linkedin.com/in/jeffrey-simmons-4b352a1a/" title="" rel="noopener noreferrer" target="_blank">purpose-driven leader</a>” on a mission to fight hunger — echoing the megachurch founder Rick Warren’s best-selling book “The Purpose-Driven Life,” which Mr. Simmons has read and taken to heart. He uses social media to spread a sort of protein-affordability gospel: “<a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://twitter.com/hashtag/Protein?src=hash" title="" rel="noopener noreferrer" target="_blank">#Protein</a> is a nutritious part of a balanced diet, but many don’t have access to it,” he <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://twitter.com/JeffSimmons2050/status/679306402083418112" title="" rel="noopener noreferrer" target="_blank">once wrote on Twitter</a>. “We can/must change this!”</p><p class="css-exrw3m evys1bk0">While microbiologists emphasize the urgency of fighting antibiotic resistance, agrochemical industry veterans like Mr. Simmons say it must be balanced against hunger and the world’s growing demand for food. He often recounts his time as an executive in Brazil, when an anguished guard in his gated community sought help <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1299&context=rangebeefcowsymp" title="" rel="noopener noreferrer" target="_blank">feeding his two children</a>. </p><p class="css-exrw3m evys1bk0">“I’m not doing it for a paycheck or profits,” Mr. Simmons said in an interview. “Purpose has to override that.”</p><p class="css-exrw3m evys1bk0">(He does get a paycheck, though. His <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.sec.gov/Archives/edgar/data/1739104/000104746919000609/a2237775zs-4a.htm" title="" rel="noopener noreferrer" target="_blank">total compensation</a> was $5.4 million last year.) </p></div><aside class="css-o6xoe7"></aside></div><div class="css-79elbk" data-testid="photoviewer-wrapper"><div class="css-z3e15g" data-testid="photoviewer-wrapper-hidden"></div><div data-testid="photoviewer-children" class="css-1a48zt4 ehw59r15"><figure class="css-1ef8w8q e1g7ppur0" aria-label="media" role="group" itemprop="associatedMedia" itemscope="" itemid="https://static01.nyt.com/images/2019/05/24/science/00GERMS-porkcongress2/00GERMS-porkcongress2-articleLarge.jpg?quality=90&auto=webp" itemtype="http://schema.org/ImageObject"><div class="css-1xdhyk6 erfvjey0"><span class="css-1ly73wi e1tej78p0">Image</span><div class="css-zjzyr8"><div data-testid="lazyimage-container" style="height:309.3333333333333px"></div></div></div><figcaption itemprop="caption description" class="css-18crmh6 e1xdpqjp0"><span aria-hidden="true" class="css-8i9d0s e13ogyst0">Elanco’s booth at the World Pork Expo in Des Moines last year.</span></figcaption></figure></div></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">Financial disclosures for Elanco and its rival Zoetis, which spun off from Pfizer in 2013, show the two companies sell roughly $2 billion annually in livestock antibiotics. In Elanco’s case, antibiotic sales represent more than one-third of its overall business. Some antibiotics, like monensin, a top seller for Elanco, belong to a class not used in people, and thus are not considered a resistance threat. But so-called shared-class antibiotics, like chlortetracycline, are used in humans and animals, creating risk for resistant infections.</p><p class="css-exrw3m evys1bk0">Mr. Simmons said that while Elanco “started as an antibiotic company,” antibiotics that are medically important for people and used in livestock feed now make up only 5 percent of its sales. “We’re not building our company on that 5 percent,” he said. But the company has also said that 12 percent of Elanco’s sales overall, including antibiotics used in feed and administered in other ways, come from medically important antibiotics.</p></div><aside class="css-o6xoe7"></aside></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">While consumer demand has made developing alternatives an industry imperative, few companies are eager to cede ground on existing business.</p><p class="css-exrw3m evys1bk0">Del Holzer, who was the director of meat and poultry for Elanco’s global industry food team from 2012 to 2017, said the company and its competitors want to take positive steps and look good, to a point. </p><p class="css-exrw3m evys1bk0">“They want to do the right thing,” said Mr. Holzer, who now works for a division of the agriculture giant Cargill, an Elanco competitor that develops antibiotic alternatives. “But they say, ‘My bottom line is my shareholders will be really pissed at me.’”</p><h2 class="css-ani50b eoo0vm40" id="link-4bdc6741">An antibiotic boom</h2></div><aside class="css-o6xoe7"></aside></div><div class="css-79elbk" data-testid="photoviewer-wrapper"><div class="css-z3e15g" data-testid="photoviewer-wrapper-hidden"></div><div data-testid="photoviewer-children" class="css-1a48zt4 ehw59r15"><figure class="css-1ef8w8q e1g7ppur0" aria-label="media" role="group" itemprop="associatedMedia" itemscope="" itemid="https://static01.nyt.com/images/2019/02/01/science/00ELANCO-nyse/00ELANCO-nyse-articleLarge.jpg?quality=90&auto=webp" itemtype="http://schema.org/ImageObject"><div class="css-1xdhyk6 erfvjey0"><span class="css-1ly73wi e1tej78p0">Image</span><div class="css-zjzyr8"><div data-testid="lazyimage-container" style="height:309.3333333333333px"></div></div></div><figcaption itemprop="caption description" class="css-18crmh6 e1xdpqjp0"><span aria-hidden="true" class="css-8i9d0s e13ogyst0">Mr. Simmons, left, ringing the bell at the New York Stock Exchange last year.</span><span itemprop="copyrightHolder" class="css-vuqh7u e1z0qqy90"><span class="css-1ly73wi e1tej78p0">Credit</span><span>Brendan McDermid/Reuters</span></span></figcaption></figure></div></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">When antibiotics were first discovered more than a century ago, no one intended them for animals. But then an American company, Lederle Laboratories, announced in 1950 that chickens grew faster when they were fed chlortetracycline, one of the drugs included in the Pig Zero campaign.</p><p class="css-exrw3m evys1bk0">By the early 1960s, almost half of livestock antibiotics were aimed at making animals fatter. Drugs were marketed by the barrel; a 50-pound chlortetracycline bag <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.documentcloud.org/documents/6140039-1972-Pfizer-and-Cyanamid.html" title="" rel="noopener noreferrer" target="_blank">advertised</a> in 1972 in The Herald, in Jasper, Ind., cost $9.25.</p><p class="css-exrw3m evys1bk0">A Purina Pig Chow ad that appeared in an Iowa newspaper in the early 1960s promised that it was “power packed with the potent vitamins, minerals and anti-biotics pigs need for fast growth and good health.” Another ad, in a Missouri paper, promoted “full-o-pep Pig Grower,” a feed laced with antibiotics.</p></div><aside class="css-o6xoe7"></aside></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">Yet scientists already had misgivings. In 1969, the <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://publications.parliament.uk/pa/ld199798/ldselect/ldsctech/081vii/st0706.htm" title="" rel="noopener noreferrer" target="_blank">Swann Committee report</a>, commissioned by the British Parliament, concluded the problem of antibiotic resistance was significant. In 1976, a landmark study published in Nature found that resistant E. coli strains could be passed from chickens fed with antibiotics to other chickens, and then to farm workers.</p><p class="css-exrw3m evys1bk0">“It was pretty obvious to me that the prudent thing to do would be to take low levels of antibiotics out of animal feed,” said Dr. Hansen, the former state epidemiologist in Kansas. As an F.D.A. employee in 1978, she gathered evidence for Congress linking antibiotic use in livestock to resistant infections in humans, but no action was taken.</p><p class="css-exrw3m evys1bk0">“The science was there, the evidence was pretty easy,” she said. “It was a slam dunk.”</p><p class="css-exrw3m evys1bk0">The pharmaceutical industry has pushed back. In 1997, researchers from Elanco were among those who authored a lengthy <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2672.1997.00280.x" title="" rel="noopener noreferrer" target="_blank">review</a> in the Journal of Applied Microbiology dismissing concerns about antibiotic use in animals, writing, “We are confronted by a lack of information, a wall of ignorance.”</p><p class="css-exrw3m evys1bk0">Pharma companies kept a stranglehold on basic information. Various <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.pewtrusts.org/en/research-and-analysis/articles/2013/02/06/recordhigh-antibiotic-sales-for-meat-and-poultry-production" title="" rel="noopener noreferrer" target="_blank">estimates</a> by academics and public policy groups claim as much as <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/http://livablefutureblog.com/2010/12/new-fda-numbers-reveal-food-animals-consume-lion%E2%80%99s-share-of-antibiotics" title="" rel="noopener noreferrer" target="_blank">80 percent</a> of American antibiotic sales go to livestock. But the industry has <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.ahi.org/issues-advocacy/animal-antibiotics/antibiotics-in-livestock-frequently-asked-questions/#05" title="" rel="noopener noreferrer" target="_blank">assailed such projections</a>, calling some “<a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/http://www.ahi.org/wp-content/uploads/2011/04/Animal-Antibiotics-Keeping-Animals-Healthy.pdf" title="" rel="noopener noreferrer" target="_blank">agenda-driven junk science</a>,” while simultaneously <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.congress.gov/bill/114th-congress/house-bill/2459" title="" rel="noopener noreferrer" target="_blank">lobbying to block</a> legislation requiring more disclosure of antibiotic use.</p><p class="css-exrw3m evys1bk0">Mr. Simmons of Elanco has long played down livestock’s role in spreading resistant microbes to humans.</p><p class="css-exrw3m evys1bk0">“The most serious pathogens are not related to antibiotics used in food animals,” he said. “Of the 18 major antibiotic-resistant threats that the C.D.C. tracks, only two, campylobacter and nontyphoidal salmonella, are associated with animals.”</p><p class="css-exrw3m evys1bk0">But such <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://web.archive.org/web/20181101165725/https:/www.elanco.com/antibiotics-progress-report" title="" rel="noopener noreferrer" target="_blank">oft-repeated statements</a>, made even in Elanco’s securities filings, refer only to food-borne strains like antibiotic-resistant salmonella that <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.cdc.gov/salmonella/infantis-10-18/index.html" title="" rel="noopener noreferrer" target="_blank">can be found</a><a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.cdc.gov/salmonella/infantis-10-18/index.html" title="" rel="noopener noreferrer" target="_blank"> in raw chicken</a>, for example, while ignoring the myriad ways pathogens can be transferred.</p></div><aside class="css-o6xoe7"></aside></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">There is a <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.ncbi.nlm.nih.gov/pubmed/29103690" title="" rel="noopener noreferrer" target="_blank">growing body</a> of<a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://jcm.asm.org/content/56/3/e01384-17" title="" rel="noopener noreferrer" target="_blank"> research</a> establishing <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.mdmag.com/medical-news/c-difficile-rt078-frequently-transfers-between-livestock-humans-irrespective-of-geographic-origins" title="" rel="noopener noreferrer" target="_blank">links</a> between Clostridium difficile, or C. diff, in livestock and humans, viewed by the C.D.C. as an urgent threat. Broad-spectrum antibiotics in livestock provide “a survival advantage to antibiotic-resistant C. difficile strains,”<a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://academic.oup.com/gastro/article/6/3/157/5046687" title="" rel="noopener noreferrer" target="_blank"> </a><a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://academic.oup.com/gastro/article/6/3/157/5046687" title="" rel="noopener noreferrer" target="_blank">according to a 2018 study by</a><a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://academic.oup.com/gastro/article/6/3/157/5046687" title="" rel="noopener noreferrer" target="_blank"> Australian researchers</a>. Similar studies exist <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.ncbi.nlm.nih.gov/pubmed/29554996" title="" rel="noopener noreferrer" target="_blank">for E. coli</a> and methicillin-resistant Staphylococcus aureus, known as <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://mbio.asm.org/content/3/2/e00082-12" title="" rel="noopener noreferrer" target="_blank">MRSA</a> — the C.D.C. <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.cdc.gov/healthypets/diseases/ecoli.html" title="" rel="noopener noreferrer" target="_blank">even lists</a> different animals like cows, goats, sheep and deer that can pass E. coli to humans.</p><p class="css-exrw3m evys1bk0">“We’ve seen antibiotic-resistant bacteria that can leak into the environment through water and dust, jump to the skin of farmers and swap genes with other bacteria,” said Sarah Sorscher, deputy director of Regulatory Affairs at the Center for Science in the Public Interest, an advocacy group. “And that’s still just scratching the surface on the science. By the time we understand the full magnitude of this threat, it may be too late.”</p><p class="css-exrw3m evys1bk0">There has been progress. In 2017, when the F.D.A. effectively banned the use of medically important antibiotics to fatten livestock, their consumption <a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.fda.gov/downloads/ForIndustry/UserFees/AnimalDrugUserFeeActADUFA/UCM628538.pdf" title="" rel="noopener noreferrer" target="_blank">fell by a third</a> that year.</p><p class="css-exrw3m evys1bk0">But health experts say the regulations did not go far enough and see a sleight of hand at work, with industry marketing now presenting routine antibiotic use as a “proactive” necessity and weight gain an ancillary benefit, as Elanco did in the Pig Zero marketing campaign.</p><p class="css-exrw3m evys1bk0">Before her death last year, Representative Louise M. Slaughter, a New York Democrat who was the only microbiologist serving in Congress, lamented the F.D.A.’s new rules as being riddled with loopholes.</p><p class="css-exrw3m evys1bk0">“It’s useless,” she said of the regulations. “That’s why the industry’s supporting it.”</p><h2 class="css-ani50b eoo0vm40" id="link-7040b672">A move to alternatives</h2></div><aside class="css-o6xoe7"></aside></div><div class="css-79elbk" data-testid="photoviewer-wrapper"><div class="css-z3e15g" data-testid="photoviewer-wrapper-hidden"></div><div data-testid="photoviewer-children" class="css-1a48zt4 ehw59r15"><figure class="css-1ef8w8q e1g7ppur0" aria-label="media" role="group" itemprop="associatedMedia" itemscope="" itemid="https://static01.nyt.com/images/2019/06/08/science/08germs-elanco-print-jump-2/merlin_147683751_9168e355-bb0e-4c3e-aba9-b9fb69d3f9ea-articleLarge.jpg?quality=90&auto=webp" itemtype="http://schema.org/ImageObject"><div class="css-1xdhyk6 erfvjey0"><span class="css-1ly73wi e1tej78p0">Image</span><div class="css-zjzyr8"><div data-testid="lazyimage-container" style="height:309.3333333333333px"></div></div></div><figcaption itemprop="caption description" class="css-18crmh6 e1xdpqjp0"><span aria-hidden="true" class="css-8i9d0s e13ogyst0">Aaron Schacht, head of research and development at Elanco. “Could we eliminate the need for broad-spectrum antibiotics?” he asked. “I think it’s possible.”</span><span itemprop="copyrightHolder" class="css-vuqh7u e1z0qqy90"><span class="css-1ly73wi e1tej78p0">Credit</span><span>Whitten Sabbatini for The New York Times</span></span></figcaption></figure></div></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">A recent tour of Elanco’s labs at its Indiana headquarters swept past a virology lab and a large machine analyzing the DNA of thousands of hamster cells. Amid beakers and hardware, scientists in coats and protective glasses discussed their efforts to find alternatives to antibiotics.</p></div><aside class="css-o6xoe7"></aside></div><div class="css-1fanzo5 StoryBodyCompanionColumn"><div class="css-53u6y8"><p class="css-exrw3m evys1bk0">Aaron Schacht, Elanco’s head of research and development, said those alternatives could include enhancing the animals’ own immune function, immunizing them against particular pathogens or reshaping their gut bacteria to favor the good ones.</p><p class="css-exrw3m evys1bk0">“Could we eliminate the need for broad-spectrum antibiotics? I think it’s possible,” he said. “Now let’s let the science play out.”</p><p class="css-exrw3m evys1bk0">But change comes in fits and starts. Mr. Holzer, the former Elanco official, said the drugmaker had created “country-specific websites” where “there were certain things you couldn’t talk about in the U.S., but then talk about in Poland.”</p><p class="css-exrw3m evys1bk0">“It’s a bit of a hypocritical thing,” he added. “Elanco wants to lead the charge on antibiotic use but then sells into these countries that could become the biggest part of the problem. The idea is that as long as we don’t lose antibiotics in country XYZ, we can take our hit in the U.S., and get the P.R. for it.”</p><p class="css-exrw3m evys1bk0">Elanco called Mr. Holzer’s comments “completely inaccurate.” Colleen Dekker, a spokeswoman, said the company no longer included “growth promotion” — fattening up animals — as an approved use for medically important antibiotics worldwide, “regardless of what local regulations allow.” The company was also intentionally decreasing its sales of such drugs, she said, showing that “this is far more than a ‘P.R. effort.’”</p><p class="css-exrw3m evys1bk0">But for Pig Zero, the company sees a problem only in the marketing. Going forward, Ms. Dekker said, such drugs would be sold “more from a health perspective” than from “a weight-gain perspective.” Mr. Simmons said of The Times’s inquiries, “We had a lot of dialogue about Pig Zero that probably we wouldn’t have had,” adding, “That’s good.” </p><p class="css-exrw3m evys1bk0"><strong class="css-8qgvsz ebyp5n10"><em class="css-2fg4z9 e1gzwzxm0">[</em></strong><strong class="css-8qgvsz ebyp5n10"><a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/http://on.fb.me/1paTQ1h" title="" rel="noopener noreferrer" target="_blank"><em class="css-2fg4z9 e1gzwzxm0">Like the Science Times page on Facebook.</em></a></strong><strong class="css-8qgvsz ebyp5n10"><em class="css-2fg4z9 e1gzwzxm0"> </em></strong><em class="css-2fg4z9 e1gzwzxm0">| Sign up for the </em><strong class="css-8qgvsz ebyp5n10"><a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/http://nyti.ms/1MbHaRU" title="" rel="noopener noreferrer" target="_blank"><em class="css-2fg4z9 e1gzwzxm0">Science Times newsletter.</em></a></strong><strong class="css-8qgvsz ebyp5n10"><em class="css-2fg4z9 e1gzwzxm0">]</em></strong></p></div><aside class="css-o6xoe7"></aside></div><div class="css-g92qtk epkadsg3"><div class="css-1owp1gq epkadsg0">Related</div><div class="css-15g2oxy epkadsg2"><div class="css-2b3w4o e16ij5yr6"><a class="css-1g7m0tk" href="https://web.archive.org/web/20190621100134/https://www.nytimes.com/2018/05/25/opinion/sunday/meat-antibiotics-organic-farming.html?action=click&module=RelatedLinks&pgtype=Article"><div class="css-i9gxme e16ij5yr4"><div class="css-14b9hti e16ij5yr5">Opinion | William D. Cohan</div><div class="css-1j8dw05 e16ij5yr2">Antibiotics in Meat Could Be Damaging Our Guts</div><time class="css-rqb9bm e16638kd0" datetime="2018-05-25">May 25, 2018</time></div><div class="css-1vm5oi9 e16ij5yr0"><img src="https://web.archive.org/web/20190621100134im_/https://static01.nyt.com/images/2018/05/24/opinion/24cohanSub/24cohanSub-threeByTwoSmallAt2X-v2.jpg" class="css-32rbo2 e16ij5yr1"/></div></a></div></div></div></section><div class="bottom-of-article"><div class="css-1ubp8k9"></div><div class="css-wg1cha"><div class="css-19hdyf3 e1e7j8ap0"><div><p>Danny Hakim is an investigative reporter for the business section. He has been a European economics correspondent and bureau chief in Albany and Detroit. He was also a lead reporter on the team awarded the 2009 Pulitzer Prize for Breaking News. <span class="css-4w91ra"> <a href="https://web.archive.org/web/20190621100134/https://twitter.com/dannyhakim" class="css-1rj8to8" rel="noopener noreferrer" target="_blank"><span class="css-0">@</span>dannyhakim</a> <span class="css-19ln2d8">•</span> <a href="https://web.archive.org/web/20190621100134/https://www.facebook.com/danny.hakim.100" class="css-1rj8to8" rel="noopener noreferrer" target="_blank">Facebook</a> </span></p></div></div><div class="css-19hdyf3 e1e7j8ap0"><div><p>Matt Richtel is a best-selling author and Pulitzer Prize-winning reporter based in San Francisco. He joined The Times staff in 2000, and his work has focused on science, technology, business and narrative-driven storytelling around these issues. <p>  <span class="css-4w91ra"> <a href="https://web.archive.org/web/20190621100134/https://twitter.com/mrichtel" class="css-1rj8to8" rel="noopener noreferrer" target="_blank"><span class="css-0">@</span>mrichtel</a> </span></p></div></div></div><div class="css-vdv0al">A version of this article appears in print on , on Page A1 of the New York edition with the headline: Antibiotic Push in Healthy Pigs Is Producing Hard-to-Kill Germs<span>. <a href="https://web.archive.org/web/20190621100134/http://www.nytreprints.com/">Order Reprints</a> | <a href="https://web.archive.org/web/20190621100134/http://www.nytimes.com/pages/todayspaper/index.html">Today’s Paper</a> | <a href="https://web.archive.org/web/20190621100134/https://www.nytimes.com/subscriptions/Multiproduct/lp8HYKU.html?campaignId=48JQY">Subscribe</a></span></div><div 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","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.3.content.0":{"__typename":"TextInline","text":"But at last year’s big swine industry trade show, the World Pork Expo in Des Moines, one of the largest manufacturers of drugs for livestock was pushing the opposite message. ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.5.content.0":{"__typename":"TextInline","text":"“Don’t wait for Pig Zero,” warned a poster featuring a giant picture of a pig peeking through an enormous blue zero, at a booth run by the drugmaker Elanco.","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.7.content.0":{"__typename":"TextInline","text":"The company’s ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.7.content.1":{"__typename":"TextInline","text":"Pig Zero brochures","formats":[{"type":"id","generated":true,"id":"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.7.content.1.formats.0","typename":"LinkFormat"}]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.7.content.1.formats.0":{"__typename":"LinkFormat","url":"https:\u002F\u002Fweb.archive.org\u002Fweb\u002F20190621100134\u002Fhttps:\u002F\u002Fwww.documentcloud.org\u002Fdocuments\u002F6140032-Pig-Zero-Combined-4.html","title":""},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.7.content.2":{"__typename":"TextInline","text":" encouraged farmers to give antibiotics to every pig in their herds rather than waiting to treat a disease outbreak caused by an unknown ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.7.content.3":{"__typename":"TextInline","text":"Patient Zero","formats":[{"type":"id","generated":true,"id":"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.7.content.3.formats.0","typename":"LinkFormat"}]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.7.content.3.formats.0":{"__typename":"LinkFormat","url":"https:\u002F\u002Fweb.archive.org\u002Fweb\u002F20190621100134\u002Fhttps:\u002F\u002Fwww.imdb.com\u002Ftitle\u002Ftt3458254\u002F","title":""},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.7.content.4":{"__typename":"TextInline","text":". It was an appealing pitch for industrial farms, where crowded, germ-prone conditions have led to increasing reliance on drug interventions. The pamphlets also detailed how ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.7.content.5":{"__typename":"TextInline","text":"feeding pigs a daily regimen of two antibiotics","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.7.content.6":{"__typename":"TextInline","text":" would make them fatter and, as any farmer understands, a heavier pig is a more profitable pig. ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.9.content.0":{"__typename":"TextInline","text":"The rise of drug-resistant germs, caused by overuse of antibiotics, is one of the world’s most nettlesome health predicaments. Excessive use of the medicines has allowed germs to develop defenses against them, rendering a growing number of drugs ineffective for people and animals. The practices of livestock farmers, who for decades have used huge quantities of the drugs deemed important to humans, have long been viewed as one of the roots of the problem, but the role of the companies that make the drugs has received less scrutiny.","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.11.content.0":{"__typename":"TextInline","text":"Antibiotics continue to be an important part of the business of companies like Elanco, which spun off from Eli Lilly in September, its share price soaring to $33 from $24. While Elanco is developing antibiotic alternatives for animals, like vaccines and enzymes, the antibiotics promoted by the Pig Zero campaign are exactly the kinds that global public health officials are trying to curb. And Elanco is no outlier — its rivals are also urging aggressive use of ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.11.content.1":{"__typename":"TextInline","text":"their own antibiotic cocktails","formats":[{"type":"id","generated":true,"id":"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.11.content.1.formats.0","typename":"LinkFormat"}]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.11.content.1.formats.0":{"__typename":"LinkFormat","url":"https:\u002F\u002Fweb.archive.org\u002Fweb\u002F20190621100134\u002Fhttps:\u002F\u002Fweb.archive.org\u002Fweb\u002F20190604015203\u002Fhttps:\u002F\u002Fwww.zoetisus.com\u002Fproducts\u002Fbeef\u002Fbovatec.aspx?_ga=2.127535694.216929652.1537192460-1078237251.1536078211","title":""},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.11.content.2":{"__typename":"TextInline","text":". ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.13.content.0":{"__typename":"TextInline","text":"“The reality is that antibiotics and large-scale industrial farming really grew up together,” said Dr. Gail Hansen, a former state epidemiologist and state public health veterinarian in Kansas, who sits on advisory boards addressing antibiotic resistance. She equated the problem with climate change. “By the time people understand and believe it,” Dr. Hansen said, “it may be too late.”","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.15.content.0":{"__typename":"TextInline","text":"Elanco had already been put on notice about the drugs used in ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.15.content.1":{"__typename":"TextInline","text":"its Pig Zero ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.15.content.2":{"__typename":"TextInline","text":"push. In 2015, the Food and Drug Administration ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.15.content.3":{"__typename":"TextInline","text":"warned","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.15.content.4":{"__typename":"TextInline","text":" Novartis Animal Health, which had been acquired by Elanco, that the same antibiotic cocktail was “unsafe” and “misbranded,” because it was being illegally marketed to fatten pigs, rather than to simply treat disease. One of the drugs, tiamulin, has been a top seller for Elanco; ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.15.content.5":{"__typename":"TextInline","text":"the W.H.O. views it as medically important to humans, but American regulators do not","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.15.content.6":{"__typename":"TextInline","text":". Pig Zero trumpets the benefits of coupling tiamulin with chlortetracycline, a drug made by Elanco’s competitors that both American and international regulators consider ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.15.content.7":{"__typename":"TextInline","text":"medically important","formats":[{"type":"id","generated":true,"id":"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.15.content.7.formats.0","typename":"LinkFormat"}]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.15.content.7.formats.0":{"__typename":"LinkFormat","url":"https:\u002F\u002Fweb.archive.org\u002Fweb\u002F20190621100134\u002Fhttp:\u002F\u002Fwww.who.int\u002Ffoodsafety\u002Fpublications\u002Fcia2017.pdf?ua=1","title":""},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.15.content.8":{"__typename":"TextInline","text":" to humans. ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.17.content.0":{"__typename":"TextInline","text":"In an interview at Elanco’s headquarters outside Indianapolis, Jeffrey Simmons, the chief executive, said the company had decided to change the program’s marketing and to stop distributing the Pig Zero brochure after The New York Times began asking questions about it. ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.19.content.0":{"__typename":"TextInline","text":"“We’re trying to be stewards and leaders at the same time,” said Mr. Simmons, adding that the brochure “wasn’t misrepresentation, necessarily, relative to the label or the science, or how a farmer would look at it.”","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.21.content.0":{"__typename":"TextInline","text":"Dr. ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.21.content.1":{"__typename":"TextInline","text":"Shabbir Simjee","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.21.content.2":{"__typename":"TextInline","text":", Elanco’s chief medical officer, said drugs like those in the campaign “would never be administered” in a herd “without some animals being physically sick,” adding that “there would need to be some animals showing clinical signs.”","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.23.content.0":{"__typename":"TextInline","text":"He likened treating a herd to caring for children in a nursery: “If one child gets sniffles, you usually find that the whole class ends up with a cold, and this is exactly the same principle.”","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.25.content.0":{"__typename":"TextInline","text":"But children almost certainly would not all be treated with preventive antibiotics in such a situation, and many scientists believe animals often should not be treated that way, either.","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.27.content.0":{"__typename":"TextInline","text":"The connection of overuse of antibiotics in livestock to human health takes two paths: As bacteria develop defenses against drugs widely used in animals, those defense mechanisms can spread to other bacteria that infect humans; and, resistant germs are transmitted from livestock to humans — through undercooked meat, farm-animal feces seeping into waterways, waste lagoons that overflow after natural disasters like ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.27.content.1":{"__typename":"TextInline","text":"Hurricane Florence","formats":[{"type":"id","generated":true,"id":"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.27.content.1.formats.0","typename":"LinkFormat"}]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.27.content.1.formats.0":{"__typename":"LinkFormat","url":"https:\u002F\u002Fweb.archive.org\u002Fweb\u002F20190621100134\u002Fhttps:\u002F\u002Fwww.nytimes.com\u002F2018\u002F09\u002F19\u002Fclimate\u002Fflorence-hog-farms.html","title":""},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.27.content.2":{"__typename":"TextInline","text":", or when farm workers and others come into ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.27.content.3":{"__typename":"TextInline","text":"contact with animals","formats":[{"type":"id","generated":true,"id":"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.27.content.3.formats.0","typename":"LinkFormat"}]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.27.content.3.formats.0":{"__typename":"LinkFormat","url":"https:\u002F\u002Fweb.archive.org\u002Fweb\u002F20190621100134\u002Fhttps:\u002F\u002Foem.bmj.com\u002Fcontent\u002F72\u002F2\u002F90","title":""},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.27.content.4":{"__typename":"TextInline","text":".","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.29.content.0":{"__typename":"TextInline","text":"[Read other articles in our series ","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.29.content.1":{"__typename":"TextInline","text":"Deadly Germs, Lost Cures","formats":[{"type":"id","generated":true,"id":"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.29.content.1.formats.0","typename":"LinkFormat"}]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.29.content.1.formats.0":{"__typename":"LinkFormat","url":"https:\u002F\u002Fweb.archive.org\u002Fweb\u002F20190621100134\u002Fhttps:\u002F\u002Fwww.nytimes.com\u002Fseries\u002Fdeadly-germs-lost-cures","title":""},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.29.content.2":{"__typename":"TextInline","text":".]","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.30.media":{"summary":"Bacteria are rebelling. They’re turning the tide against antibiotics by outsmarting our wonder drugs. This video explores the surprising reasons.","firstPublished":"2019-04-06T09:00:06.000Z","aspectRatio":"16:9","transcript":"There once was a man named Albert Alexander. He was a policeman — “[American accent] Hey.” — in England. “[British accent] Hello.” One day on patrol, he cut his cheek — “Ouch!” — which led to a terrible infection. See, this was back in 1941, before patients had antibiotics. These were the days when a little scratch could kill you. “Or you got an ear infection and you died. A cat bite and you died. Or you stepped on a stick and you died. All of a sudden, antibiotics come along and bang.” The antibiotic era had begun. Soon a slow and painful death became a seven-day course of antibiotics and a $10 copay. And Albert? Albert was the first patient in the world to receive the antibiotic — penicillin. And it worked. “We just came up with a lifesaving, life-extending drug, one of the greatest developments in human history. Except not.” That’s Matt Richtel, a science reporter for The New York Times. For the past year, Matt’s been talking to health experts to find out if we are reaching the end of the antibiotic era. Modern medicine depends on the antibiotic. “And having used it so much, we’re now putting it at risk. Is our fate sealed?” “First off, I don’t think people respect bacteria enough.” This is Ellen Silbergeld, one of the leading scientists studying antibiotic resistance. “Bacteria rule the world. We are just a platform for bacteria. Within the human body, there are more bacterial cells than there are human cells. So we are, in fact, mostly bacteria.” “Alexander Fleming —” the man who discovered penicillin “— in his Nobel speech said, hang on, be aware. When you start killing this stuff off, it’s going to fight back.” “Did we pay any attention to that? No.” “The C.D.C. got our attention today with a warning about what it calls ‘nightmare bacteria.’” “These are bacteria that are resistant to most, if not all, antibiotics.” When we take antibiotics to kill infections, some bacteria survive. It used to be they’d replicate, and eventually resistance would grow. But now, they’re way more efficient and share drug-resistant genes among themselves. So every time we take an antibiotic, we risk creating stronger, more resistant bacteria. And stronger, more resistant bacteria means less and less effective antibiotics. And this is a problem because we take lots of antibiotics. “Money gets made over the sale of antibiotics.” Big money. Globally, the antibiotics market is valued at $40 billion. And in the U.S., the C.D.C. estimates that about 30 percent of all prescribed antibiotics are not needed at all. That’s 47 million excess prescriptions. And in many places outside of the U.S., you don’t even need a prescription. “You can walk into a pharmacy. A pharmacist will diagnose you and give you antibiotics. I tend to think of it as a story of Darwinian forces multiplied by the pace and scale of global capitalism. In an interconnected world — travel, import, export — we’re moving the bugs with us.” “I can go to a meeting in China or Vietnam or some place —” This is Lance Price, the director of the Antibiotic Resistance Action Center. “I can become colonized by untreatable E. coli. And I might not have any symptoms. But you can get colonized. And you can become this sort of long-term host.” So you could be healthy and still spreading bad bacteria without even knowing it. “Drug-resistant bacteria have never been able to travel the world as fast as they do today.” And that’s just part of the problem. “You should know that about 80 percent of antibiotic production in this country goes into agriculture.” “Why on earth did somebody think putting antibiotics in agriculture was a great idea?” “We’ve said, hey, look, cram these animals together. Don’t worry too much about hygiene or trying to keep them healthy. Just give them antibiotics. And then in a couple weeks, you’re going to have full-grown animals that you can chop up and eat. Right? And you can make money off of that.” “Nobody was making the connection between feeding animals antibiotics and the fact that the food would be carrying drug-resistant bacteria.” So Ellen did a study. She compared different kinds of store-bought chicken. And she found that poultry raised with antibiotics had nine times as much drug-resistant bacteria on it. “Now, let’s talk about the vegetarians. I just want you to understand, you’re not safe. You know all these outbreaks that take place among the lettuce and the things like that. Have you ever wondered how that happened? It’s because animal manure is used in raising crops. Organic agriculture lauds the use of animal manure.” “Unless you’re just a complete, ‘I’m a vegan, and I only hang out with vegans, and I eat sterilized vegetables,’ you know, it’s very likely that you’re picking up the same bacteria.” Resistant bacteria seep into the groundwater, fly off the back of livestock trucks and hitch a ride home on the hands of farm workers, all of which makes trying to pinpoint exactly where resistant bacteria is originating extremely difficult. And even when it seems like there is a clear source, things still aren’t so simple. “No one wants to be seen as a hub of an epidemic.” Say your grandmother makes you a rump roast. And then that rump roast makes you sick. Well, if you live in France, or Ireland, or pretty much anywhere in the E.U., packaged meat has a tracking label. You can figure out exactly what farm that meat came from. But in the U.S., not even the top public health officials can do that. “Most countries have animal ID laws. We don’t.” Pat Basu, former chief veterinarian for the U.S.D.A.’s Food Safety and Inspection Service, basically one of the top veterinarians in the country. “Let me start at the beginning. We got a case where we had resistant bacteria causing illness in people. There were sick people that C.D.C. identified.” “More than 50 people in eight counties have gotten an unusual strain of salmonella linked to pork.” “This is not your grandmother’s pathogen anymore. This is a new bug.” Health officials traced the outbreak back to the slaughterhouse and identified six potential farms where the outbreak could have come from. But then the investigation shut down. “The individual farmers have to agree voluntarily to share the data with these investigators who go out. We couldn’t go any further back. It was a dead end.” 192 people sick, 30 hospitalizations and zero access for health officials to investigate the farms. “The secrecy is maintained because there are big economic forces behind it. Farms are scared of losing their ability to get antibiotics. Hospitals are scared of driving away patients.” “Well, as a physician, I do get very upset. I get very upset, as a patient, that information is being withheld.” This is Kevin Kavanagh, a doctor and a consumer advocate for patients. “Drug-resistant bacteria is a huge problem. If it occurs at a restaurant, if it occurs in a cruise ship, you know about this immediately —” “A salmonella outbreak —” “within days or hours of an outbreak occurring.” “This morning, Chipotle is keeping dozens of its restaurants in the Pacific Northwest closed —” “But yet, in a hospital, it can take you months or even over a year until this data appears on a governmental website or reported by the C.D.C.” In the U.S., hospitals are under no obligation to inform the public when a bacterial outbreak occurs. “Defend and deny. They are very concerned about the short-term economic benefits, rather than looking at long-term problems.” “There’s always this response like, well, but there’s still a drug, right? Like, this isn’t the end.” Remember Albert Alexander? — “Hello. Ouch!” — the first patient to be given penicillin? Well, his story didn’t end there. Five days after he started recovering, the hospital ran out of the new drug, and Mr. Alexander died. Today, we don’t have to worry about antibiotics running out. We have to worry about using them so much that they stop working altogether. “— want to know why a metro health department didn’t shut down a restaurant —” “It’s a very resistant bacteria —” “We really need to change the way we use antibiotics. Because the way we use antibiotics is destroying them.” “It’s putting at risk the entire system of care that we depend on for lengthening our lives and improving the quality of our lives.” The British government commissioned a study which predicted a worst case scenario where more people will die by 2050 of these infections than will die of cancer. “That’s a generation from now.” “It takes 10 years to identify, develop, test and bring to market a new antibiotic. And it takes a billion dollars.” “This is a common issue for humanity.” “Very similar to global warming.” “You can’t control it as a single company. 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Worldwide use is projected to keep rising sharply as growing middle classes in places like China and Brazil demand more meat.","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.34.content.0":{"__typename":"TextInline","text":"Ellen Silbergeld","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.34.content.1":{"__typename":"TextInline","text":", a professor at Johns Hopkins University, who has worked with the W.H.O. on drug resistance, called the continuing promotion of the drugs by pharmaceutical companies “very dangerous.”","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.36.content.0":{"__typename":"TextInline","text":"“The reason they’re doing it, though, is money, honey,” she added. “That’s what it’s all about. 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In Elanco’s case, antibiotic sales represent more than one-third of its overall business. Some antibiotics, like monensin, a top seller for Elanco, belong to a class not used in people, and thus are not considered a resistance threat. But so-called shared-class antibiotics, like chlortetracycline, are used in humans and animals, creating risk for resistant infections.","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.62.content.0":{"__typename":"TextInline","text":"Mr. Simmons said that while Elanco “started as an antibiotic company,” antibiotics that are medically important for people and used in livestock feed now make up only 5 percent of its sales. “We’re not building our company on that 5 percent,” he said. But the company has also said that 12 percent of Elanco’s sales overall, including antibiotics used in feed and administered in other ways, come from medically important antibiotics.","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.64.content.0":{"__typename":"TextInline","text":"While consumer demand has made developing alternatives an industry imperative, few companies are eager to cede ground on existing business.","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.66.content.0":{"__typename":"TextInline","text":"Del Holzer, who was the director of meat and poultry for Elanco’s global industry food team from 2012 to 2017, said the company and its competitors want to take positive steps and look good, to a point. 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I think it’s possible,” he said. “Now let’s let the science play out.”","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.114.content.0":{"__typename":"TextInline","text":"But change comes in fits and starts. Mr. Holzer, the former Elanco official, said the drugmaker had created “country-specific websites” where “there were certain things you couldn’t talk about in the U.S., but then talk about in Poland.”","formats":[]},"$Article:QXJ0aWNsZTpueXQ6Ly9hcnRpY2xlLzI4NTE1YzkyLWFhNzktNTAxOS1iNTkxLTdjMjA2NTk3ZjMzMg==.sprinkledBody.content@filterEmpty.116.content.0":{"__typename":"TextInline","text":"“It’s a bit of a hypocritical thing,” he added. “Elanco wants to lead the charge on antibiotic use but then sells into these countries that could become the biggest part of the problem. 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Going forward, Ms. Dekker said, such drugs would be sold “more from a health perspective” than from “a weight-gain perspective.” Mr. Simmons said of The Times’s inquiries, “We had a lot of dialogue about Pig Zero that probably we wouldn’t have had,” adding, “That’s good.” 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