CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "jpet.aspetjournals.org",cType: 'managed',cRay: '917d4ec4ce4efe0d',cH: 'L1XwmKu8xmaVqZNeALRNaC8iiD1jAUyea53E.V7j4I4-1740545357-1.2.1.1-cF1T_FnLO8IcWsMi47IVdY5KzLjfrVSwvSEQttWt6hLCqt6P2wM41ojWZj803Hwf',cUPMDTk: "\/content\/375\/1?__cf_chl_tk=.trO3zg1UkFf.pz3XJj993wB5x60qU339Sx.QFwe1aI-1740545357-1.0.1.1-QErN5WktZWKsYagh1TzknXQfXKF0jXMftUOXNqDk6XU",cFPWv: 'b',cITimeS: '1740545357',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/content\/375\/1?__cf_chl_f_tk=.trO3zg1UkFf.pz3XJj993wB5x60qU339Sx.QFwe1aI-1740545357-1.0.1.1-QErN5WktZWKsYagh1TzknXQfXKF0jXMftUOXNqDk6XU",md: "YR60ouUOwMK_uMTSMIOukh3O.wtopfB.PiJTwF3ooHQ-1740545357-1.2.1.1-OGrAmkdtPDAo.iOhSkZKnVxiiSlgvWu7VrXQHiCQKkmikm_KYH0XzXoLWlDN5CCKFzk9zKI8.wzZqI0qkKHtpecjdEAnIZRapxdNs9q.0qKFjFoYkCS0kEptxHODPGFhkvDHTPvd9YnGTct7U0Qd.R._s_Y7_JcgOQ6CZ9U0FijCS8YFf1iYoEs0MjKmIztz55t36fwjb5Gzg3jKDB3Mj3BwyuGNm0MjvJvxgmWxJk8TgqcYujwxZtI6mQf_KHTzgfXDCIV.Y8hmsfVF1OxO0rvbG4zVZ3uYSS6K8Oae_sup10PATgoZpLoiTxGpnaFkmLJjo6.KORkfCr.sZ7ldmL37SurKut7huS6o3ay5ZEE2trYK02WUST1dSHf4LvCDOrYgRPDu.IWd9zjGPDEqzaHrtxg1jGY_tvaz0XJHMj1UXYIyR63IOs_58OS75zIivWFRPSIvT9stN_NqFF7X66qAmpSkC5XRKjBMZCdi2QyfmAUGaSdmX6yLIbN0G_XZuzHC_Jxc2rmtMdvBNANPh8MSz.SrARgWJBv0IdhABSQJnhmtksUvwqAtWTCdPgI5NeHx7LbHp_CuFeFDxSSpmBxL3loiuW7sKTYMRJPNf411Gl5ZD9dPb2mRw0pxjvnvj4CCUGt.qv4OV5B.289oQDUk6vjTbViacvY.aJnS4ggOPrFZVonaJtXLgJJLTs.wm1K1scK12JbvH.XTV5F9Pvcp_y_NMaYpPlBRkjxcbsppb3iI0pWCNfkLK6ZsiGFCVb9kRv8wfo8w70GkSRepsg7_bNy0gJCKzgPi0WIhxKF710y5feGRowsCRYRjJaCTQBjR_FRTJkkhiC85Be6qBpoU6A0tkcUv24Fur4dIDEVniVMCXu.9rEqRM9JnYHPunU1VarP3sqj1pOqgNDwVp6BbeF3FC.6vt61HXsry2xxikedoSwOpzSLDS1TfMLogFOKn.qJiuQVGNJ6C1kcygNhEvItyWsLDqGe22KKxOeysYe.VVvWXlSReDTX5cLnPtIMSXqWSAx4BTzLm9IjCbKdlu41mcbv68piCkQOPbfg71dP4.hY6LoCOh8w1JYZIfmqKR18qQR6bg4eVLj1M_.KlTff9hnZGaMgdgqlZji1s0R0_ws4kl4ret8junXsHhw4bf2F2zjp9b3KQRhpEodVuZFuk3Revq2iYvv6pZJiy7fw_YrF4R._yUmajaCq3XAbRkAZvE2kh0Sl292dku2TQnHxzOAWU8LbxzaXOcNXb8PBBH8G3wc_BRRp8ANR2OKA04975haez79Nf8YE5nTPnjp03IauQj6Zr613lPPjntq9OJbM8TLzBfUyS8i182vOnJ.9Lj55swKK1aVU1GwxkX6hLMP0WSbyBRrrvSm9lY90iMpbchZUoJDrsnpXPGkIe6zJFvN5xocbuGBYnx8XGd7j5YMz8yMpl_B41n7DpiML5cEM71q8bLlYkTYfeZn.t4VEQNGEseUPQHvpCypDjPuD6B8x.GiTJ.XUvV2i_jhPspj.YWfLGw7kuN8S1ZToUqmJXY1lvckDPuBJa16VxY5GhZhmkwA5YW6cgxsqitdd7pdijaFsRr61D5QJE3.zmu2f_Q2dej1A6G5T2uw4RpPPVnh9xb0hEEN4G4oASNbQ4z3.TaO_ZFyz8CDRqbKYFdPBTTM_fx0Pe0ovO._C08Xnc4z_w1puBGTwZmmaWbNYahB8k3tOlrROth5U3eyLp1Y8cJMeWKeXf_fPcYaC8lGsv.ld2nTkrdfdzFiyLY4jsYm7j4dA_6szJsVkhTCu50Wzzyiiff0kq04U_2I3Osp385XTQLXsrz5YZWgmPEJ.17xXPNiTyRjdIUogeXebpcJv7KWBrh_gYa6NPfTExkNdVyM_Eb1NZ08cJWraor_aXDOO0Tb9AqPZ_rEqbeOQEiM5co7JO9L2uOViitVK_v.xJmFB26hfshFGYPuL7QHsp1tzQ.8NrKodUmqRFivgFqNSmPIBTKAA.GQEhnK2PZ.xd.GS.ps2DtCP85blt_ozjEr6bxM2k67vj2ND.Oa5iQuD8XCtK.yLFmoPAO.g.PFxTWdgWFQSa9iqhyYoy.qwBbBVMblzKIGQT.7WNui4A9j25PgrhUn2F3OfnzvhLGBiMAEHl.szrLVsYrRF4mMQmdS8VSmZS5Zw_EuIUhahNwafMhboyhlyeHDronb.CDOAcey3EtD.hYMzfWXpxlV6FGyGX0X8vpfiZxiMgVa0bSp137u3TO.89Ic5no7CnUJL.bayPyQqBWhqJ40uXmnwCQibMcR1BN8X9QiLgQfaZGsEXi._Nk9MRKLJpq.mHlXw7dYgNf6hLtvhFiKecpeLjNVOQV7yT_9H3_KC6p8Vwl0E66y_9S70bqfeLF2DsimP78skOqHNcg8UIu9TE8BtSNKzwZ9OpR3pBTo1mWIOSxCmad6L7QjxNoyjS7sTvOC68gWMc6LOWg8m9MtqrLlcVFLUtAAiCf1Aahd.Wk73ORgQFYr_Qgj.g2kcWowgLOe0HDE_0c7V4fcV6bnvYrjmLZAyb8amVQmOgqUDs",mdrd: "YukXjTgT3LmdiL.eIMw7qaE7Ae.ZjK1OrOZqaImLqaw-1740545357-1.2.1.1-SJHWRBQ1Nyqz4IKh4J5lRHJKZDVwaoaur9Q1PDx..1NAfzUCV70e7ZEvF08mVSIBN5um2pOpgiczlWAfP_4F113cji2AlyWxrbYmqBfJ352nlEvTr8cQbRsFMj2m4SWoY6aFUAKZT0kU1fvsG98qLP9aI3HrboMxT15d.pKCr0Acxf8HsoNFZ6bcreiM7gA7Xx9luR3DOM8gSTvp47g4THzR5_sEUou8AmzHVxp4oBOhxsBq2y4tL.iVqpx4rkvGqNz5Yjl8RFU3iE.lCKi0gvqp.uursj_CwkZGLKIdiHyqGqAbgQnydOxFwAjIUwLF5aLRotyHpf2dc_PZ.3tDP4buHMn4iQ4VOG.JupUaLiuSGiBhOQ7HA6R3_DSqxJuNtZcdV9S6cXOtwhTvXDtm5yibLFO0LVg8R91TNV0ke5RnTkqOZwRD6lFaAnqDsq9PYpsnb7mHqhtqYXZ_Qyk8JVh1EknAkpw_NkjzFZRRV3lrcqybO5kHuUEisiXQ9d4fyX_RAamU_LbzUc.QD89gHutPEiMmLi1JUoUk82pSn_k64axHvmaRWs0M_ZcuSmZCPm4YxjW7qcX6C39.XrZgWMy6Ti4.DjxeRHSUUrmfn5Ogx0rjtFT9fOgte0UI4gFIWfdXcJ18pozlrCq2dnzAWsePEdHriXF3Uj8AJDq7UXblK.PBm3CBg8grlEud2Mo5.q7DrG7Sq57BoIiVNoGTIkLNJa94903TuCBewTOzWkgYzTiYm3c8utd6Do741z3AWVUpJPEoUoYE72W4SrRQr7VVfGw6KzFgTEUHtZhLFGxl6dYRwMBwMQtsiMeGbEApiFg8muBZzug_f7PD1ENDaaYArwYZangqr0PzbufiVu1OsDE_nAm47ykr1Or99OFhs.Ex7oJVQDziyIH0DbBO9bdei9tPcC8RWB6ulrHlHTKz2pKDsiPMzOmK6BRQoA4SV5AonzLniMDPVGK_kJle7OJZqYhKTi81DKGgzunNCwj6NVz1iWS6UzurLZF8C1jt29eNxqA92e_24D6faapzC4Ev951fk78Rl5ZDiJ39G_bh0d9kfEdyGmT7pYYFHkB_yAYu6_q4aOPY2Nhjz2DviG61tGywEpFA3hqb1BcXkx2JVnKN.b06Go7E3YmGlqlI6XO3FXglR0SZxyo9V0v2.d3CfGZ0EUBjuNaAWkmMSCh3pwKfayGyPpBzoUloPouwIIDlhJtwtRjNz2a4RM1_4vl3KaMkLLaJVqprQvoVaUT3vc_mA2fVAjbCGPLM2GcBHAHck4vuE6AghPb8hdyPbYnS2PYbGAjWLFdXMr5W1E8uJbFraexoTISvg5geppN98spXAgFo3ZyUG1gaS_E1gG5LJlT0592AR6kzeVfk5sesuPUbyfsg5B783_ckoiLoZZZImKhKOaXoUMzPOfjr3812EOeUhZxso7MYtZIpj3YrheQUnCAjsFfNnnhhlSoBlHqZgeF2Vab.lwEq_B9j_pGMBfBLZICIBgzrrf_PZ5uwE.pfHE0uFH3THrRRCoapqQ3FN9jQW4c4_lR1F_BEVa8.kPW4cXFAMAR_9K786OZZOVgKDljWcVM4hy.qY0J1xRJ9L7bUEBA6ZV9ICYjFMUGMevIcmmtOrH2xAk39d2N3BeuwGIs7BSPr5l7m.nnViZ2S4wGmA6Zz0ElMSFoIOikGw8qJo5YlSSOyXIRk1oi9Dsmet017N2L0jQ8gxPvrUBJDzEZojEo3qC4g_OgzILfs8vFymLMKFPrP.YpdXP4Au7Kv3agS53RkbdztPTuDVI1j4.QCuXUOMW0Dg42IuYrsJLl0BzcWC.AXbR1DrqWPrda5pGb91JboWvtts9oFVKYjxuDa7Qt_Q3YzdWSLbGyR7tbpuNImza_rraj.6auULP8xUzk94AYrWvVh3GJia_bHO7fcwoASc.JpSBls9DVHztla6YehEXoaQKJhCmXfLnhOtk6Mr31j45w9RAmJvWIreZApL4eT44mUxu5E9w"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=917d4ec4ce4efe0d';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/content\/375\/1?__cf_chl_rt_tk=.trO3zg1UkFf.pz3XJj993wB5x60qU339Sx.QFwe1aI-1740545357-1.0.1.1-QErN5WktZWKsYagh1TzknXQfXKF0jXMftUOXNqDk6XU" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>