CINXE.COM

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href="/science/applications/research-areas/learning-and-memory">Learning and Memory</a></li><li><a href="/science/applications/research-areas/g-protein-coupled-receptors-ion-channels">G-protein-coupled Receptors & Ion Channels</a></li><li><a href="/science/applications/research-areas/post-mortem-brain-tissue">Post-mortem Brain Tissue</a></li></ul></div></div></div><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Other</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/research-solutions/circular-rna">Circular RNA</a></li><li><a href="/science/applications/research-solutions/gene-fusions">Gene Fusions</a></li><li><a href="/science/applications/research-solutions/ngsht-transcriptomic-validation-rna-seq">HT Transcript Validation</a></li><li><a href="/science/applications/research-solutions/long-noncoding-rna">Long Non-coding RNA</a></li><li><a href="/science/applications/research-solutions/ngsht-transcriptomic-validation-rna-seq">RNAseq Validation</a></li><li><a href="/science/applications/research-solutions/single-cell-analysis">Single Cell Analysis</a></li><li><a href="/science/applications/research-solutions/splice-variant">Splice Variant</a></li><li><a href="/science/applications/research-solutions/mirna">miRNA</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">RNA & Protein</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/research-solutions/antibody-challenges-and-validation">Antibody Challenges</a></li><li><a href="/science/applications/research-solutions/dual-ish-and-ihc">Dual ISH + IHC Methods</a></li><li><a href="/science/applications/research-solutions/no-antibodies-available">No Antibodies</a></li><li><a href="/science/applications/research-solutions/ish-and-ihc-complementary">RNA & Protein Analysis</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Customer Innovations</div> <span class="sectitle-span">+</span><ul><li><a href="/innovations-rnascope">Dual RNA+DNA ISH</a></li><li><a href="/innovations-rnascope">Very old FFPE ISH</a></li><li><a href="/innovations-rnascope">Wholemount ISH</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Animal Models</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/animal-models/virtually-any-species">Any Species</a></li><li><a href="/science/applications/animal-models/mouse-model">Mouse Model</a></li><li><a href="/science/applications/animal-models/preclinical-safety-assessment">Preclincal Safety</a></li></ul></div></div></div></div></li><li class="level0 technology"> <a href="/science/technology-overview" class="level0">Technology</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title"><a href="/science/technology-overview">Overview</a></div> <span class="sectitle-span">+</span><ul><li><a href="/science/how-it-works">How it Works</a></li><li><a href="/science/technology-overview/image-gallery">Data Image Gallery</a></li><li><a href="https://www.youtube.com/watch?v=CPgZEf6EyJQ&feature=youtu.be" target="_blank">Technology Video</a></li><li><a href="/technical-support/learn-more">Webinars</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">RNA Detection</div> <span class="sectitle-span">+</span><ul><li><a href="/science/why-rna">Why RNA?</a></li><li><a href="/science/applications/rna-ish-ihc/overview">RNA ISH and IHC</a></li></ul><div class="sec-title">Pretreatment Options</div> <span class="sectitle-span">+</span><ul><li><a href="/rnascope%E2%84%A2-pretreatment">RNAscope™ Pretreatment</a></li><li><a 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in RNA ISH Technology for Spatial Gene Expression</h1></div><div class="container publications-container"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs" id="myTab"><li><a href="/science/technology-overview">ISH Technology</a></li><li><a href="/science/applications">Applications</a></li><li><a href="/science/why-rna">Why RNA ISH?</a></li><li><a href="/science/spotlights">Spotlights</a></li><li class="active"><a href="/science/scientific-resources/publications">Publications</a></li><li><a href="/science/posters">Posters</a></li></ul></div><div class="annual-container"><div class="annual-count"><div class="annual-count-left"><div class="annual-count-title">Annual Publication Count</div><div class="sub-title">Cumulative publications:</div><div class="count">10,000+</div><div class="updated">* Updated July, 2024</div></div><div class="annual-count-right"><img alt="" src="/sites/default/files/publications-july-2024.jpg" style="max-width:100%;" /></div><div 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href="/science/scientific-resources/publications/novel/researcharea/other-lung" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--81">Other: Lung (4)<span class="element-invisible"> Apply Other: Lung filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/behavior" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--82">Behavior (4)<span class="element-invisible"> Apply Behavior filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/other-zoological-disease" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--83">Other: Zoological Disease (4)<span class="element-invisible"> Apply Other: Zoological Disease filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/teeth" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--84">Teeth (4)<span class="element-invisible"> Apply Teeth filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/gene-therapy" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--85">Gene Therapy (4)<span class="element-invisible"> Apply Gene Therapy filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/behavioral" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--86">behavioral (4)<span class="element-invisible"> Apply behavioral filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/bone" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--87">Bone (3)<span class="element-invisible"> Apply Bone filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/other-metabolism" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--88">Other: Metabolism (3)<span class="element-invisible"> Apply Other: Metabolism filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/feeding-behavior" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--89">Feeding Behavior (3)<span class="element-invisible"> Apply Feeding Behavior filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/heart" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--90">Heart (3)<span class="element-invisible"> Apply Heart filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/fibrosis" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--91">Fibrosis (3)<span class="element-invisible"> Apply Fibrosis filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/circrnas" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--92">circRNAs (3)<span class="element-invisible"> Apply circRNAs filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/therapeutics" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--93">therapeutics (3)<span class="element-invisible"> Apply therapeutics filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/developmental" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--94">Developmental (2)<span class="element-invisible"> Apply Developmental filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/liver" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--95">Liver (2)<span class="element-invisible"> Apply Liver filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/eye" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--96">Eye (2)<span class="element-invisible"> Apply Eye filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/other-cell-biology" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--97">Other: Cell Biology (2)<span class="element-invisible"> Apply Other: Cell Biology filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/stress" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--98">Stress (2)<span class="element-invisible"> Apply Stress filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/other-veterinary-science" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--99">Other: Veterinary Science (2)<span class="element-invisible"> Apply Other: Veterinary Science filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/researcharea/macular-degeneration" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--100">Macular Degeneration (2)<span class="element-invisible"> Apply Macular Degeneration filter </span></a></li><li class="leaf last"><a href="/science/scientific-resources/publications/novel/researcharea/anxiety" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--101">Anxiety (2)<span class="element-invisible"> Apply Anxiety filter </span></a></li></ul></div></div></div><div id="block-facetapi-4qghbqioaspbmlriwmxbgpyg084wdrpv" class="block block-facetapi clearfix"><h2 class="title">Species common</h2><div class="content"><div class="item-list"><ul class="facetapi-facetapi-checkbox-links facetapi-facet-im-field-species-common" id="facetapi-facet-apachesolrpublication-solr-server-block-im-field-species-common"><li class="leaf first"><a href="/science/scientific-resources/publications/novel/speciescommon/mouse" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--2">Mouse (389)<span class="element-invisible"> Apply Mouse filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/human" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--3">Human (299)<span class="element-invisible"> Apply Human filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/tbd" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--4">TBD (86)<span class="element-invisible"> Apply TBD filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/rat" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--5">Rat (42)<span class="element-invisible"> Apply Rat filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/other" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--6">Other (10)<span class="element-invisible"> Apply Other filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/zebrafish" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--7">Zebrafish (10)<span class="element-invisible"> Apply Zebrafish filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/monkey" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--8">Monkey (9)<span class="element-invisible"> Apply Monkey filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/rats" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--9">Rats (8)<span class="element-invisible"> Apply Rats filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/dog" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--10">Dog (7)<span class="element-invisible"> Apply Dog filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/pig" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--11">Pig (5)<span class="element-invisible"> Apply Pig filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/virus" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--12">Virus (4)<span class="element-invisible"> Apply Virus filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/horse" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--13">Horse (3)<span class="element-invisible"> Apply Horse filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/hamster" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--14">Hamster (3)<span class="element-invisible"> Apply Hamster filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/pigs" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--15">Pigs (3)<span class="element-invisible"> Apply Pigs filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/bovine" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--16">Bovine (2)<span class="element-invisible"> Apply Bovine filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/sheep" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--17">Sheep (2)<span class="element-invisible"> Apply Sheep filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/drosophila" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--18">Drosophila (2)<span class="element-invisible"> Apply Drosophila filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/salmon" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--19">Salmon (2)<span class="element-invisible"> Apply Salmon filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/macaque" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--20">Macaque (2)<span class="element-invisible"> Apply Macaque filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/cow" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--21">Cow (2)<span class="element-invisible"> Apply Cow filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/deer" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--22">Deer (2)<span class="element-invisible"> Apply Deer filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/racoon" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--23">Racoon (1)<span class="element-invisible"> Apply Racoon filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/plant" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--24">Plant (1)<span class="element-invisible"> Apply Plant filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/phoca-vitulina" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--25">Phoca vitulina (1)<span class="element-invisible"> Apply Phoca vitulina filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/virus-hiv" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--26">Virus-HIV (1)<span class="element-invisible"> Apply Virus-HIV filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/hepatitis-b-virus" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--27">Hepatitis B virus (1)<span class="element-invisible"> Apply Hepatitis B virus filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/alpaca-polyomavirus" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--28">Alpaca Polyomavirus (1)<span class="element-invisible"> Apply Alpaca Polyomavirus filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/chicken" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--29">Chicken (1)<span class="element-invisible"> Apply Chicken filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/cat" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--30">Cat (1)<span class="element-invisible"> Apply Cat filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/rainbow-trout" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--31">rainbow trout (1)<span class="element-invisible"> Apply rainbow trout filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/goat" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--32">Goat (1)<span class="element-invisible"> Apply Goat filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/swine" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--33">Swine (1)<span class="element-invisible"> Apply Swine filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/bats" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--34">Bats (1)<span class="element-invisible"> Apply Bats filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/mouse-humanized" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--35">Mouse (Humanized) (1)<span class="element-invisible"> Apply Mouse (Humanized) filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/porcupine" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--36">Porcupine (1)<span class="element-invisible"> Apply Porcupine filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/humanized-mouse" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--37">Humanized Mouse (1)<span class="element-invisible"> Apply Humanized Mouse filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/hamsters" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--38">Hamsters (1)<span class="element-invisible"> Apply Hamsters filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/macaques" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--39">Macaques (1)<span class="element-invisible"> Apply Macaques filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/african-green-monkeys%C2%A0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--40">African green monkeys (1)<span class="element-invisible"> Apply African green monkeys filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/octopus" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--41">Octopus (1)<span class="element-invisible"> Apply Octopus filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/humanized-zebrafish" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--42">(Humanized) Zebrafish (1)<span class="element-invisible"> Apply (Humanized) Zebrafish filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/avian" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--43">Avian (1)<span class="element-invisible"> Apply Avian filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/wallaby" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--44">Wallaby (1)<span class="element-invisible"> Apply Wallaby filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/turtle" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--45">Turtle (1)<span class="element-invisible"> Apply Turtle filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/perca-fluviatilis" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--46">Perca fluviatilis (1)<span class="element-invisible"> Apply Perca fluviatilis filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/bank-voles" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--47">Bank voles (1)<span class="element-invisible"> Apply Bank voles filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/toxocara-canis" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--48">Toxocara canis (1)<span class="element-invisible"> Apply Toxocara canis filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/dogs" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--49">Dogs (1)<span class="element-invisible"> Apply Dogs filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/speciescommon/yesso-scallops" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--50">Yesso scallops (1)<span class="element-invisible"> Apply Yesso scallops filter </span></a></li><li class="leaf last"><a href="/science/scientific-resources/publications/novel/speciescommon/human-vero-cells" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--51">Human Vero Cells (1)<span class="element-invisible"> Apply Human Vero Cells filter </span></a></li></ul></div></div></div><div id="block-facetapi-me8miflrpzemzgefduwk3xxabiv13rxf" class="block block-facetapi clearfix"><h2 class="title">Product</h2><div class="content"><div class="item-list"><ul class="facetapi-facetapi-checkbox-links facetapi-facet-im-field-product" id="facetapi-facet-apachesolrpublication-solr-server-block-im-field-product"><li class="leaf first"><a href="/science/scientific-resources/publications/novel/product/rnascope" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--102">RNAscope (155)<span class="element-invisible"> Apply RNAscope filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-multiplex-fluorescent-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--103">RNAscope Multiplex Fluorescent Assay (119)<span class="element-invisible"> Apply RNAscope Multiplex Fluorescent Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-fluorescent-multiplex-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--104">RNAscope Fluorescent Multiplex Assay (110)<span class="element-invisible"> Apply RNAscope Fluorescent Multiplex Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-25-hd-red-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--105">RNAscope 2.5 HD Red assay (91)<span class="element-invisible"> Apply RNAscope 2.5 HD Red assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-20-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--106">RNAscope 2.0 Assay (87)<span class="element-invisible"> Apply RNAscope 2.0 Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-25-hd-brown-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--107">RNAscope 2.5 HD Brown Assay (38)<span class="element-invisible"> Apply RNAscope 2.5 HD Brown Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-25-ls-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--108">RNAscope 2.5 LS Assay (34)<span class="element-invisible"> Apply RNAscope 2.5 LS Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/tbd" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--109">TBD (31)<span class="element-invisible"> Apply TBD filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-25-hd-duplex-0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--110">RNAscope 2.5 HD Duplex (23)<span class="element-invisible"> Apply RNAscope 2.5 HD Duplex filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/basescope-assay-red-0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--111">BASEscope Assay RED (22)<span class="element-invisible"> Apply BASEscope Assay RED filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-25-vs-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--112">RNAscope 2.5 VS Assay (14)<span class="element-invisible"> Apply RNAscope 2.5 VS Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/basescope" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--113">Basescope (13)<span class="element-invisible"> Apply Basescope filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-multiplex-fluorescent-v2" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--114">RNAscope Multiplex Fluorescent v2 (11)<span class="element-invisible"> Apply RNAscope Multiplex Fluorescent v2 filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-25-hd-reagent-kit-brown-1" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--115">RNAscope 2.5 HD Reagent Kit - BROWN (10)<span class="element-invisible"> Apply RNAscope 2.5 HD Reagent Kit - BROWN filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/mirnascope" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--116">miRNAscope (6)<span class="element-invisible"> Apply miRNAscope filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-hiplex-v2-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--117">RNAscope HiPlex v2 assay (3)<span class="element-invisible"> Apply RNAscope HiPlex v2 assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-multiplex-fluorescent-reagent-kit-v2" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--118">RNAscope Multiplex fluorescent reagent kit v2 (2)<span class="element-invisible"> Apply RNAscope Multiplex fluorescent reagent kit v2 filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/rnascope-25-hd-duplex-reagent-kit" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--119">RNAscope 2.5 HD duplex reagent kit (2)<span class="element-invisible"> Apply RNAscope 2.5 HD duplex reagent kit filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/dnascope-hd-duplex-reagent-kit" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--120">DNAscope HD Duplex Reagent Kit (2)<span class="element-invisible"> Apply DNAscope HD Duplex Reagent Kit filter 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</span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/novel/product/dnascope-duplex-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--127">DNAscope Duplex Assay (1)<span class="element-invisible"> Apply DNAscope Duplex Assay filter </span></a></li><li class="leaf last"><a href="/science/scientific-resources/publications/novel/product/rnascope-hiplex12-reagents-kit" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--128">RNAscope HiPlex12 Reagents Kit (1)<span class="element-invisible"> Apply RNAscope HiPlex12 Reagents Kit filter </span></a></li></ul></div></div></div></div></div></div></div><div class="col-sm-9 result"><div class="region region-content"><div id="block-system-main" class="block block-system clearfix"><div class="content"><div class="search-results apachesolr_search-results"><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.mdpi.com/1999-4915/14/5/1012"> Characterization of a Novel Reassortant Epizootic Hemorrhagic Disease Virus Serotype 6 Strain Isolated from Diseased White-Tailed Deer (Odocoileus virginianus) on a Florida Farm </a></div></div><div class="col-sm-2"><p>Viruses</p></div><div class="col-sm-2"><p>2022 May 10</p></div><div class="clear"></div><div class="col-sm-8"><p> Rodrigues, TCS;Viadanna, PHO;Subramaniam, K;Hawkins, IK;Jeon, AB;Loeb, JC;Krauer, JMC;Lednicky, JA;Wisely, SM;Waltzek, TB; <br/> PMID: <a href="https://www.mdpi.com/1999-4915/14/5/1012" target="_blank">35632753</a> | DOI: 10.3390/v14051012</p></div><div class="clear"></div><div class="descp publication-abstract-read"> We report an outbreak of a novel reassortant epizootic hemorrhagic disease virus serotype 6 (EHDV-6) in white-tailed deer (WTD) on a Florida farm in 2019. At necropsy, most animals exhibited hemorrhagic lesions in the lung and heart, and congestion in the lung, liver, and spleen. Histopathology revealed multi-organ hemorrhage and congestion, and renal tubular necrosis. Tissues were screened by RT-qPCR and all animals tested positive for EHDV. Tissues were processed for virus isolation and next-generation sequencing was performed on cDNA libraries generated from the RNA extracts of cultures displaying cytopathic effects. Six isolates yielded nearly identical complete genome sequences of a novel U.S. EHDV-6 strain. Genetic and phylogenetic analyses revealed the novel strain to be most closely related to a reassortant EHDV-6 strain isolated from cattle in Trinidad and both strains received segment 4 from an Australian EHDV-2 strain. The novel U.S. EHDV-6 strain is unique in that it acquired segment 8 from an Australian EHDV-8 strain. An RNAscope in situ hybridization assay was developed against the novel U.S. EHDV-6 strain and labeling was detected within lesions of the heart, kidney, liver, and lung. These data support the novel U.S. reassortant EHDV-6 strain as the cause of disease in the farmed WTD.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.hindawi.com/journals/tbed/2023/8512021/"> Identification of a Novel Astrovirus Associated with Bovine Respiratory Disease </a></div></div><div class="col-sm-2"><p>Transboundary and Emerging Diseases</p></div><div class="col-sm-2"><p>2023 Apr 04</p></div><div class="clear"></div><div class="col-sm-8"><p> Nelsen, A;Knudsen, D;Hause, B; <br/> | DOI: 10.1155/2023/8512021</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Astroviruses (AstVs) cause gastrointestinal disease in mammals and avians. Emerging evidence suggests that some AstVs have extraintestinal tissue tropism, with AstVs detected in the liver, kidney, central nervous system, and the respiratory tract variably associated with disease. In cattle, AstV infection has been linked to gastroenteric or neurologic disease. Here, metagenomic sequencing of a lung from a bovine with respiratory disease identified a novel AstV with a predicted capsid-encoding ORF2 amino acid sequence with 66% identity to caprine astrovirus (CAstV G2.1). A quantitative reverse transcription PCR (qRT-PCR) targeting ORF2 found four out of 49 (8%) lungs and one out of 48 (2%) enteric samples obtained from bovine diagnostic submissions positive for the novel bovine astrovirus (BAstV). In two strongly qRT-PCR-positive lung samples, intense novel BAstV nucleic acid signals were mainly localized in the cytoplasm of alveolar macrophages and mononuclear cells using RNAscope in situ hybridization (ISH). Genetic analysis of two novel BAstV genomes determined from qRT-PCR positive samples found high similarity for ORF1ab nucleotide sequence (92.1% and 93.9%) to BAstV strain BSRI-1, while ORF2 nucleotide sequence was most similar to CAstV G2.1 (74.6% and 77.6%). Phylogenetic analysis of the novel BAstV sequences found a close genetic relationship to the single BAstV (BSRI-1) previously identified from a bovine respiratory sample as well as bovine and caprine AstVs identified from various tissues. Further research is needed to determine the clinical significance of BAstV in respiratory diseases.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name">Somatostatin Interneurons of the Insula Mediate QR2-Dependent Novel Taste Memory Enhancement</div></div><div class="col-sm-2"><p>eNeuro</p></div><div class="col-sm-2"><p>2021 Sep 29</p></div><div class="clear"></div><div class="col-sm-8"><p> Gould, NL;Kolatt Chandran, S;Kayyal, H;Edry, E;Rosenblum, K; <br/> PMID: 34518366 | DOI: 10.1523/ENEURO.0152-21.2021</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Forming long-term memories is crucial for adaptive behavior and survival in changing environments. The molecular consolidation processes which underlie the formation of these long-term memories are dependent on protein synthesis in excitatory and SST-expressing neurons. A centrally important, parallel process to this involves the removal of the memory constraint quinone reductase 2 (QR2), which has been recently shown to enhance memory consolidation for novel experiences in the cortex and hippocampus, via redox modulation. However, it is unknown within which cell type in the cortex removal of QR2 occurs, nor how this affects neuronal function. Here, we use novel taste learning in the mouse anterior insular cortex (aIC) to show that similarly to mRNA translation, QR2 removal occurs in excitatory and SST-expressing neurons. Interestingly, both novel taste and QR2 inhibition reduce excitability specifically within SST, but not excitatory neurons. Furthermore, reducing QR2 expression in SST, but not in PV or excitatory neurons, is sufficient to enhance taste memory. Thus, QR2 mediated intrinsic property changes of SST interneurons in the aIC is a central removable factor to allow novel taste memory formation. This previously unknown involvement of QR2 and SST interneurons in resetting aIC activity hours following learning, describes a molecular mechanism to define cell circuits for novel information. Therefore, the QR2 pathway in SST interneurons provides a fresh new avenue by which to tackle age-related cognitive deficits, while shedding new light onto the functional machinations of long-term memory formation for novel information.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://academic.oup.com/endo/advance-article-abstract/doi/10.1210/endocr/bqad076/7162087"> Novel candidate regulators and developmental trajectory of pituitary thyrotropes </a></div></div><div class="col-sm-2"><p>Endocrinology</p></div><div class="col-sm-2"><p>2023 May 15</p></div><div class="clear"></div><div class="col-sm-8"><p> Cheung, LYM;Menage, L;Rizzoti, K;Hamilton, G;Dumontet, T;Basham, K;Daly, AZ;Brinkmeier, ML;Masser, BE;Treier, M;Cobb, J;Delogu, A;Lovell-Badge, R;Hammer, GD;Camper, SA; <br/> PMID: <a href="https://academic.oup.com/endo/advance-article-abstract/doi/10.1210/endocr/bqad076/7162087" target="_blank">37183548</a> | DOI: 10.1210/endocr/bqad076</p></div><div class="clear"></div><div class="descp publication-abstract-read"> The pituitary gland regulates growth, metabolism, reproduction, the stress response, uterine contractions, lactation, and water retention. It secretes hormones in response to hypothalamic input, end organ feedback, and diurnal cues. The mechanisms by which pituitary stem cells are recruited to proliferate, maintain quiescence or differentiate into specific cell types, especially thyrotropes, are not well understood. We utilized single-cell RNA sequencing in juvenile P7 mouse pituitary cells to identify novel factors in pituitary cell populations, with a focus on thyrotropes and rare subtypes. We first observed cells co-expressing markers of both thyrotropes and gonadotropes, such as Pou1f1 and Nr5a1. This was validated in vivo by both immunohistochemistry and lineage tracing of thyrotropes derived from Nr5a1-Cre; mTmG mice and demonstrates that Nr5a1-progenitors give rise to a proportion of thyrotropes during development. Our dataset also identifies novel factors expressed in pars distalis and pars tuberalis thyrotropes, including the Shox2b isoform in all thyrotropes and Sox14 specifically in Pou1f1-negative pars tuberalis thyrotropes. We have therefore used single-cell transcriptomics to determine a novel developmental trajectory for thyrotropes and potential novel regulators of thyrotrope populations.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.atsjournals.org/doi/abs/10.1165/rcmb.2022-0222OC"> Enhanced Expression of a Novel Lamin A/C Splice Variant in IPF Lung </a></div></div><div class="col-sm-2"><p>American journal of respiratory cell and molecular biology</p></div><div class="col-sm-2"><p>2023 Feb 27</p></div><div class="clear"></div><div class="col-sm-8"><p> Yin, Q;Morris, GF;Saito, S;Zhuang, Y;Thannickal, VJ;Jazwanski, SM;Lasky, JA; <br/> PMID: <a href="https://www.atsjournals.org/doi/abs/10.1165/rcmb.2022-0222OC" target="_blank">36848480</a> | DOI: 10.1165/rcmb.2022-0222OC</p></div><div class="clear"></div><div class="descp publication-abstract-read"> In idiopathic pulmonary fibrosis (IPF), the normal delicate lung architecture is replaced with rigid extracellular matrix (ECM) due to accumulation of activated myofibroblasts and excessive deposition of ECM. Lamins have a role in fostering mechanosignaling from the ECM to the nucleus. Although there is a growing number of studies on lamins and associated diseases, there are no prior reports linking aberrations in lamins with pulmonary fibrosis. Here, we discovered through analysis of our RNA-seq data, a novel isoform of lamin A/C that is more highly expressed in IPF compared to control lung. This novel LMNA splice variant includes retained introns 10 and 11, and exons 11 and 12 as documented by RACE assay. We found that this novel isoform is induced by stiff extracellular matrix. To better clarify the specific effects of this novel isoform of lamin A/C and how it may contribute to the pathogenesis of IPF, we transduced the lamin transcript into primary lung fibroblasts and alveolar epithelial cells, and found that it impacts upon several biological effects, including cell proliferation, senescence, cell contraction, and the transition of fibroblasts to myofibroblasts. We also observed that type II epithelial cells and myofibroblasts, in IPF lung exhibited wrinkled nuclei, and this is notable because this has not been previously described and is consistent with laminopathy-mediated cellular effects.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/30804095"> Oxytocin receptors are expressed by glutamatergic prefrontal cortical neurons that selectively modulate social recognition. </a></div></div><div class="col-sm-2"><p>J Neurosci.</p></div><div class="col-sm-2"><p>2019 Feb 25</p></div><div class="clear"></div><div class="col-sm-8"><p> Tan Y, Singhal SM, Harden SW, Cahill KM, Nguyen DM, Colon-Perez LM, Sahagian TJ, Thinschmidt JS, de Kloet AD, Febo M, Frazier CJ, Krause EG. <br/> PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/30804095" target="_blank">30804095</a> | DOI: 10.1523/JNEUROSCI.2944-18.2019</p></div><div class="clear"></div><div class="descp publication-abstract-read"><p><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">Social recognition, the ability to recognize individuals that were previously encountered, requires complex integration of sensory inputs with previous experience. Here, we use a variety of approaches to discern how oxytocin sensitive neurons in the prefrontal cortex (PFC) exert descending control over a circuit mediating social recognition in mice. Using male mice with Cre-recombinase directed to the oxytocin receptor gene (</span><i style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">Oxtr</i><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">), we revealed that the </span><i style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">Oxtr</i><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;"> is expressed on glutamatergic neurons in the PFC, optogenetic stimulation of which, elicited activation of neurons residing in several mesolimbic brain structures. Optogenetic stimulation of axons in the basolateral amygdala (BLA) arising from </span><i style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">Oxtr</i><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">-expressing neurons in the PFC eliminated the ability to distinguish novel from familiar conspecifics, but remarkably, distinguishing between novel and familiar objects was unaffected. These results suggest that an oxytocin sensitive PFC to BLA circuit is required for social recognition. The implication is that impaired social memory may manifest from dysregulation of this circuit.</span><b style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">SIGNIFICANCE STATEMENT</b><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">Using mice we demonstrate that optogenetic activation of the neurons in the prefrontal cortex (PFC) that express the oxytocin receptor gene (</span><i style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">Oxtr</i><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">) impairs the ability to distinguish between novel and familiar conspecifics but the ability to distinguish between novel and familiar objects remains intact. Subjects with Autism Spectrum Disorders (ASD) have difficulty identifying a person based on remembering facial features; however, ASD and typical subjects perform similarly when remembering objects. In subjects with ASD, viewing the same face increases neural activity in the PFC, which may be analogous to the optogenetic excitation of </span><i style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">Oxtr</i><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px;">-expressing neurons in the PFC that impairs social recognition in mice. The implication is that over-activation of Oxtr-expressing neurons in the PFC may contribute to ASD symptomology.</span></p></div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name">IN SITU DETECTION OF CRTC-MAML2 TRANSLOCATION EXPRESSION IN MUCOEPIDERMOID CARCINOMA</div></div><div class="col-sm-2"><p>Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology</p></div><div class="col-sm-2"><p>2021 Jul 01</p></div><div class="clear"></div><div class="col-sm-8"><p> Amoura, E;Hunter, K;Bingle, C;Bingle, L; <br/> | DOI: 10.1016/j.oooo.2021.03.040</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Background The heterogeneity of salivary gland neoplasms, within and between histologic types, presents a major diagnostic challenge. Mucoepidermoid carcinoma (MEC), the most common salivary gland cancer in adults, children, and adolescents, is associated with the presence of a novel CRTC1-MAML2 fusion gene. The translocation can be detected by fluorescence in situ hybridization or reverse transcription polymerase chain reaction but without information regarding transcript level, identification of the cell type(s) harboring the translocation and histologic architecture is not preserved. This study describes, for the first time, a novel in situ chromogenic assay, BaseScope, to detect CRTC1-MAML2 translocation expression. Objective Design a novel BaseScope probe targeting the novel exon-exon junction in the CRTC1-MAML2 fusion transcript, determine expression levels of the transcript, and identify specific cell types harboring the translocation. Methods Formalin-fixed paraffin-embedded tissues and known fusion-positive and -negative human MEC cells were subjected to the assay. Results The CRTC1-MAML2 RNA transcript was detected in known fusion-positive cells but not in fusion-negative cells. In MEC tissues distinct fusion events, in the form of punctate red dots, were detected in all tumor grades and all cell types. Interestingly, the translocation was specifically identified in tumor cells that had direct contact with tumor stroma or nerve invasion. No positive staining was seen in normal tissue or surrounding stroma and no unique morphological features were noted in negative cases. Conclusions The BaseScope assay accurately detects the CRTC1-MAML2 fusion translocation and thus provides an alternative chromogenic technique, for easy use in routine clinical labs, to aid accurate diagnosis of MEC.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/30012220"> Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 </a></div></div><div class="col-sm-2"><p>Genome Biol.</p></div><div class="col-sm-2"><p>2018 Jul 17</p></div><div class="clear"></div><div class="col-sm-8"><p> Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu CT, Lyyti <br/> PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/30012220" target="_blank">30012220</a> | DOI: 10.1186/s13059-018-1457-6</p></div><div class="clear"></div><div class="descp publication-abstract-read"><p>Abstract</p><p>BACKGROUND:</p><p>Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear.</p><p>RESULTS:</p><p>Here, we identify putative functional coding variation associated with changes in the QRS interval duration by combining Illumina HumanExome BeadChip genotype data from 77,898 participants of European ancestry and 7695 of African descent in our discovery cohort, followed by replication in 111,874 individuals of European ancestry from the UK Biobank and deCODE cohorts. We identify ten novel loci, seven within coding regions, including ADAMTS6, significantly associated with QRS duration in gene-based analyses. ADAMTS6 encodes a secreted metalloprotease of currently unknown function. In vitro validation analysis shows that the QRS-associated variants lead to impaired ADAMTS6 secretion and loss-of function analysis in mice demonstrates a previously unappreciated role for ADAMTS6 in connexin 43 gap junction expression, which is essential for myocardial conduction.</p><p>CONCLUSIONS:</p><p>Our approach identifies novel coding and non-coding variants underlying ventricular depolarization and provides a possible mechanism for the ADAMTS6-associated conduction changes.</p></div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.researchsquare.com/article/rs-2557290/latest.pdf"> Single-cell analysis identifies Ifi27l2a as a novel gene regulator of microglial inflammation in the context of aging and stroke </a></div></div><div class="col-sm-2"><p>Research square</p></div><div class="col-sm-2"><p>2023 Feb 15</p></div><div class="clear"></div><div class="col-sm-8"><p> Kim, GS;Harmon, E;Gutierrez, M;Stephenson, J;Chauhan, A;Banerjee, A;Wise, Z;Doan, A;Wu, T;Lee, J;Jung, JE;McCullough, L;Wythe, J;Marrelli, S; <br/> PMID: <a href="https://www.researchsquare.com/article/rs-2557290/latest.pdf" target="_blank">36824976</a> | DOI: 10.21203/rs.3.rs-2557290/v1</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Microglia are key mediators of inflammatory responses within the brain, as they regulate pro-inflammatory responses while also limiting neuroinflammation via reparative phagocytosis. Thus, identifying genes that modulate microglial function may reveal novel therapeutic interventions for promoting better outcomes in diseases featuring extensive inflammation, such as stroke. To facilitate identification of potential mediators of inflammation, we performed single-cell RNA sequencing of aged mouse brains following stroke and found that Ifi27l2a was significantly up-regulated, particularly in microglia. The increased Ifi27l2a expression was further validated in microglial culture, stroke models with microglial depletion, and human autopsy samples. Ifi27l2a is known to be induced by interferons for viral host defense, however the role of Ifi27l2a in neurodegeneration is unknown. In vitro studies in cultured microglia demonstrated that Ifi27l2a overexpression causes neuroinflammation via reactive oxygen species. Interestingly, hemizygous deletion of Ifi27l2a significantly reduced gliosis in the thalamus following stroke, while also reducing neuroinflammation, indicating Ifi27l2a gene dosage is a critical mediator of neuroinflammation in ischemic stroke. Collectively, this study demonstrates that a novel gene, Ifi27l2a, regulates microglial function and neuroinflammation in the aged brain and following stroke. These findings suggest that Ifi27l2a may be a novel target for conferring cerebral protection post-stroke.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29378907"> Mitotically-associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer </a></div></div><div class="col-sm-2"><p>Mol Cancer Res.</p></div><div class="col-sm-2"><p>2018 Jan 29</p></div><div class="clear"></div><div class="col-sm-8"><p> Tracy KM, Tye CE, Ghule PN, Malaby HLH, Stumpff J, Stein JL, Stein GS, Lian JB. <br/> PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/29378907" target="_blank">29378907</a> | DOI: 10.1158/1541-7786.MCR-17-0548</p></div><div class="clear"></div><div class="descp publication-abstract-read"><p>Aggressive breast cancer is difficult to treat as it is unresponsive to many hormone-based therapies; therefore, it is imperative to identify novel, targetable regulators of progression. Long non-coding RNAs (lncRNAs) are important regulators in breast cancer and have great potential as therapeutic targets; however, little is known about how the majority of lncRNAs function within breast cancer. This study, characterizes a novel lncRNA, MANCR (mitotically-associated long non-coding RNA; LINC00704), which is upregulated in breast cancer patient specimens and cells. Depletion of MANCR in triple-negative breast cancer (TNBC) cells significantly decreases cell proliferation and viability, with concomitant increases in DNA damage. Transcriptome analysis, based on RNA sequencing (RNA-seq), following MANCR knockdown reveals significant differences in the expression of >2000 transcripts, and gene set enrichment analysis (GSEA) identifies changes in multiple categories related to cell cycle regulation. Furthermore, MANCR expression is highest in mitotic cells by both RT-qPCR and RNA in situ hybridization. Consistent with a role in cell cycle regulation, MANCR-depleted cells have a lower mitotic index and higher incidences of defective cytokinesis and cell death. Taken together, these data reveal a role for the novel lncRNA, MANCR, in genomic stability of aggressive breast cancer, and identify it as a potential therapeutic target.</p><p>IMPLICATIONS:</p><p>The novel lncRNA, MANCR (LINC00704), is upregulated in breast cancer and is functionally linked with cell proliferation, viability, and genomic stability.</p></div></div></div><h2 class="element-invisible">Pages</h2><div class="item-list"><ul class="pager"><li class="pager-current first">1</li><li class="pager-item"><a title="Go to page 2" href="/science/scientific-resources/publications/novel?page=1">2</a></li><li class="pager-item"><a title="Go to page 3" href="/science/scientific-resources/publications/novel?page=2">3</a></li><li class="pager-item"><a title="Go to page 4" href="/science/scientific-resources/publications/novel?page=3">4</a></li><li class="pager-item"><a title="Go to page 5" href="/science/scientific-resources/publications/novel?page=4">5</a></li><li class="pager-item"><a title="Go to page 6" href="/science/scientific-resources/publications/novel?page=5">6</a></li><li class="pager-item"><a title="Go to page 7" href="/science/scientific-resources/publications/novel?page=6">7</a></li><li class="pager-item"><a title="Go to page 8" href="/science/scientific-resources/publications/novel?page=7">8</a></li><li class="pager-item"><a title="Go to page 9" href="/science/scientific-resources/publications/novel?page=8">9</a></li><li class="pager-ellipsis">…</li><li class="pager-next"><a title="Go to next page" href="/science/scientific-resources/publications/novel?page=1">next ›</a></li><li class="pager-last last"><a title="Go to last page" href="/science/scientific-resources/publications/novel?page=105">last »</a></li></ul></div><div id="probes-info-table" class="search-probes-info"><div class="ecom-feature-container"><div class="help-ticket-close ">X</div><div class="ecom-feature-content"><div class="probes-help-text classification"><table cellspacing="0" border="0"><colgroup span="3" width="85"></colgroup><thead><tr><th></th><th>Description</th></tr></thead><tbody><tr><td>sense<br><strong>Example:</strong> Hs-LAG3-sense</td><td>Standard probes for RNA detection are in antisense. Sense probe is reverse complent to the corresponding antisense probe.</td></tr><tr><td>Intron#<br><strong>Example:</strong> Mm-Htt-intron2</td><td>Probe targets the indicated intron in the target gene, commonly used for pre-mRNA detection</td></tr><tr><td>Pool/Pan<br><strong>Example:</strong> Hs-CD3-pool (Hs-CD3D, Hs-CD3E, Hs-CD3G)</td><td>A mixture of multiple probe sets targeting multiple genes or transcripts</td></tr><tr><td>No-XSp<br><strong>Example:</strong> Hs-PDGFB-No-XMm</td><td>Does not cross detect with the species (Sp)</td></tr><tr><td>XSp<br><strong>Example:</strong> Rn-Pde9a-XMm</td><td>designed to cross detect with the species (Sp)</td></tr><tr><td>O#<br><strong>Example:</strong> Mm-Islr-O1</td><td>Alternative design targeting different regions of the same transcript or isoforms</td></tr><tr><td>CDS<br><strong>Example:</strong> Hs-SLC31A-CDS</td><td>Probe targets the protein-coding sequence only</td></tr><tr><td>EnEm</td><td>Probe targets exons n and m</td></tr><tr><td>En-Em</td><td>Probe targets region from exon n to exon m</td></tr><tr><td colspan=3 style="text-align: center; font-weight: bold;">Retired Nomenclature</td></tr><tr><td>tvn<br><strong>Example:</strong> Hs-LEPR-tv1</td><td>Designed to target transcript variant n</td></tr><tr><td>ORF<br><strong>Example:</strong> Hs-ACVRL1-ORF</td><td>Probe targets open reading frame</td></tr><tr><td>UTR<br><strong>Example:</strong> Hs-HTT-UTR-C3</td><td>Probe targets the untranslated region (non-protein-coding region) only</td></tr><tr><td>5UTR<br><strong>Example:</strong> Hs-GNRHR-5UTR</td><td>Probe targets the 5' untranslated region only</td></tr><tr><td>3UTR<br><strong>Example:</strong> Rn-Npy1r-3UTR</td><td>Probe targets the 3' untranslated region only</td></tr><tr><td>Pan<br><strong>Example:</strong> Pool</td><td>A mixture of multiple probe sets targeting multiple genes or transcripts</td></tr></tbody></table></div></div></div></div> <script type="text/javascript"> 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text-align: center; text-decoration: none; display: inline-block; cursor: pointer; } .embeddedServiceInvitationFooter > #acceptInvite { background-color: #005290; color: #FFFFFF; } .embeddedServiceInvitationFooter > #rejectInvite { background-color: #FFFFFF; color: #005290; } </style>   <input type="hidden" name="liveagent.prechat.findorcreate.map.doFind:Contact" value="LastName,true;FirstName,true;Email,true" /> <input type="hidden" name="liveagent.prechat.findorcreate.map.isExactMatch:Contact" value="LastName,true;FirstName,true;Email,true" /> <input type="hidden" name="liveagent.prechat.findorcreate.map.doCreate:Contact" value="LastName,true;FirstName,true;Email,true" /> <script type='text/javascript'> (function() { document.getElementById('closeInvite').onclick = function() { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; document.getElementById('rejectInvite').onclick = function() { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; // use this API call to reject invitations document.getElementById('acceptInvite').onclick = function() { embedded_svc.liveAgentAPI.startChat({ directToButtonRouting: { buttonId: "5733t000000cVk9" }, extraPrechatInfo: [], extraPrechatFormDetails: [] }); }; // use this API call to start chat from invitations document.addEventListener('keyup', function(event) { if (event.keyCode == 27) { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }}) })(); </script>  <script type='text/javascript' src='https://service.force.com/embeddedservice/5.0/esw.min.js'></script> <script type='text/javascript'> var initESW = function(gslbBaseURL) { embedded_svc.settings.displayHelpButton = true; //Or false embedded_svc.settings.language = ''; //For example, enter 'en' or 'en-US' embedded_svc.settings.defaultMinimizedText = 'Chat now'; //(Defaults to Chat with an Expert) embedded_svc.settings.disabledMinimizedText = 'Leave a message'; //(Defaults to Agent Offline) embedded_svc.settings.autoOpenPostChat = true; //embedded_svc.settings.loadingText = ''; //(Defaults to Loading) //embedded_svc.settings.storageDomain = 'yourdomain.com'; //(Sets the domain for your deployment so that visitors can navigate subdomains during a chat session) // Settings for Chat embedded_svc.settings.directToButtonRouting = function (prechatFormData) { if (prechatFormData[4].value === "Technical Service") return "5733t000000XZAM"; if (prechatFormData[4].value === "Customer Care") return "5733t000000XZAH"; }; embedded_svc.settings.prepopulatedPrechatFields = { OmniURL__c: window.location.href, ChooseaDepartment__c: 'Technical Service' }; //Sets the auto-population of pre-chat form fields embedded_svc.settings.extraPrechatFormDetails = [{ "label":"Source Domain", "value":window.location.href, "transcriptFields":[ "Source_Domain__c" ], "displayToAgent":true }]; //embedded_svc.settings.fallbackRouting = []; //An array of button IDs, user IDs, or userId_buttonId embedded_svc.settings.offlineSupportMinimizedText = 'Leave a message'; //(Defaults to Contact Us) embedded_svc.settings.enabledFeatures = ['LiveAgent']; embedded_svc.settings.entryFeature = 'LiveAgent'; embedded_svc.init( 'https://biotechne.my.salesforce.com', 'https://biotechne.my.salesforce-sites.com/LiveAgent', gslbBaseURL, '00D500000006gkl', 'ACD_Chat_Automated', { baseLiveAgentContentURL: 'https://c.la1-c1-ia5.salesforceliveagent.com/content', deploymentId: '572380000004CqL', buttonId: '5733t000000cVk9', baseLiveAgentURL: 'https://d.la1-c1-ia5.salesforceliveagent.com/chat', eswLiveAgentDevName: 'EmbeddedServiceLiveAgent_Parent04I3t000000Y7zbEAC_175bb741b99', isOfflineSupportEnabled: true } ); }; if (!window.embedded_svc) { var s = document.createElement('script'); s.setAttribute('src', 'https://biotechne.my.salesforce.com/embeddedservice/5.0/esw.min.js'); s.onload = function() { initESW(null); }; document.body.appendChild(s); } else { initESW('https://service.force.com'); } </script> <script src="//rum-static.pingdom.net/pa-5c133f6e1872b50016000024.js" async></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"NRJS-dd6144c4de227d09eb4","applicationID":"1022125825","transactionName":"YFxbZkpUXBYEVkYNWVkWbEBRGlsLAVBKSkZfSQ==","queueTime":0,"applicationTime":311,"atts":"TBtYEAJOTxg=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>