Wang Lab | Experimental Therapeutics

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-9M4L5ZJ47J"></script> <script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag("config", "G-9M4L5ZJ47J", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","allow_ad_personalization_signals":false});</script> <meta name="description" content="Our long-term objective is to cure cancer by combining conventional therapeutics that targeting on proliferative cells with novel therapy targeting dormant cancer cells. Currently, almost all anticancer drugs used in the clinic target proliferative cancer cells. While these effective anticancer treatments can lead to cancer dormancy – a state of cancer inactivity that is considered beneficial to the patient – it also renders them unresponsive to additional conventional treatments." /> <link rel="canonical" href="https://www.bccrc.ca/dept/et/labs/wang-lab" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <style>.logo a {background-image: url(/dept/et/sites/experimentaltherapeutics/files/BCClogo_Research_ExperimentalTherapeutics_RGB.png);background-size: contain;}body .region__network .logo a {background-size: contain}</style> <link rel="icon" href="/dept/et/themes/custom/bccrc/favicon.ico" type="image/vnd.microsoft.icon" /> <title>Wang Lab | Experimental Therapeutics</title> <link rel="stylesheet" href="//use.typekit.net/rew6qot.css"> <link rel="stylesheet" media="all" href="/dept/et/sites/experimentaltherapeutics/files/css/css_bV_wyuiAnJ9zPLpoh15DqPVp5zURILiGUo0zSYNWWOU.css?delta=0&language=en&theme=bccrc&include=eJwrriwuSc3VT0osTtVJSk4uStZPz8lPSszRLS6pzMnMSwcAzMcMcA" /> <link rel="stylesheet" media="all" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css" /> <link rel="stylesheet" media="all" href="/dept/et/sites/experimentaltherapeutics/files/css/css_f9vSMEfaUUj1Vi5S5OMU9J-eyVOUVzkdzlMftZl9VdI.css?delta=2&language=en&theme=bccrc&include=eJwrriwuSc3VT0osTtVJSk4uStZPz8lPSszRLS6pzMnMSwcAzMcMcA" /> </head> <body class="colour--mahogany not-front path--node page--lab"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="main-container"> <header class="page--lab page"> <div class="region__header--inner region--inner"> <section id="block-bccrc-breadcrumbs" class="block block--system-breadcrumb-block block-bccrc-breadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/dept/et/">Experimental Therapeutics</a> </li> <li> <a href="/dept/et/labs">Research Labs & Principal Investigators</a> </li> <li> Wang Lab </li> </ol> </nav> </section> <section id="block-bccrc-page-title" class="block block--page-title-block block-bccrc-page-title"> <h1><span>Wang Lab</span> </h1> </section> </div> </header> <section class="region region__highlight"> <div class="region__highlight--inner region--inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </section> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <section class="region region__content"> <div class="region__content--inner region--inner"> <section id="block-bccrc-content" class="block block--system-main-block block-bccrc-content"> <article class="node node--lab full"> <div class="node__inner"> <footer class="node"> <aside> <a href="/dept/et/people/yuzhuo-wang" class="button"><span>Dr. Yuzhuo Wang, PhD, FCAHS</span> </a> <div class="field field--field_phone_number"><a href="tel:604-675-8013"> 604-675-8013</a></div> </aside> </footer> <div class="node__main"> <div class="field field--body"><p>Our long-term <strong>objective</strong> is to cure cancer by combining conventional therapeutics that targeting on proliferative cells with novel therapy targeting dormant cancer cells. Currently, almost all anticancer drugs used in the clinic target proliferative cancer cells. While these effective anticancer treatments can lead to cancer dormancy – a state of cancer inactivity that is considered beneficial to the patient – it also renders them unresponsive to additional conventional treatments. As such, these dormant cancer cells can be considered the <em>most</em> resistant form of cancer. Unfortunately, they can eventually become reactivated in patients, causing cancer relapse and metastasis that kills. Our specific goal is to comprehensively understand the mechanisms understanding behind how dormant cancer cells relapse and progress into metastatic castration resistant prostate cancer (mCRPC). This will enable us to develop therapeutics that delay or prevent such occurrences. (Insights gained from studying prostate cancer can also be broadly applied to other cancer types given commonly shared mechanisms.)</p> <p><strong>Hypothesis: </strong>Therapy induces a heterogeneous, but definable, repertoire of mechanisms (e.g. lineage plasticity, transdifferentiation, and dormancy) that gives rise to lethal treatment-resistant CRPC. These mechanisms can be modeled and studied in patient-derived xenografts (PDXs), which are unique tools for discovering critical drug targets and testing novel anticancer therapies. By comprehensively understanding the mechanisms underlying cancer dormancy and reactivation, novel therapies can be developed.</p> <p><strong>Program significance: </strong>We anticipate that our research will build a new paradigm of cancer drug discovery and development by using evidence-based precision oncology and employing novel strategies that focus on eliminating dormant precursors of CRPC. Through our research program, we also hope to equip a next generation of scientists and clinical fellows to appreciate team science and interdisciplinary approaches. They will deepen their expertise in cancer modeling, molecular biology, and drug development. Using this combinatory approach, they will improve our understanding of the dynamic processes driving treatment resistance and develop the clinical tools necessary to impede cancer progression. Thus, our team’s synergy will significantly advance the knowledge of cancer biology and translate it to improving patient outcomes and quality of life.</p></div> </div> </div> </article> <section id="people" class="layout layout__grid"><h2 class="section__title">Members</h2><h3 class="subsection__title">Faculty/Leaders</h3><div class="flexgrid"><article class="node node--profile teaser"> <a class="picture" href="/dept/et/people/yuzhuo-wang" ><figure> <img loading="lazy" src="/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-10/DSC07340.jpg?itok=t9YCsKco" width="580" height="460" alt="" /> </figure></a> <section> <h3 class="node__title"> <a href="/dept/et/people/yuzhuo-wang" rel="bookmark">Dr. Yuzhuo Wang, PhD, FCAHS</a> </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Distinguished Scientist</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8013"> 604-675-8013</a></div> <a href= "https://www.bccrc.ca/dept/et/contact/62" class="more">Send message</a> <a href="/dept/et/people/yuzhuo-wang" class="more" rel="bookmark">Bio <i class="fa fa-chevron-right"></i></a> </div> </section> </article> </div><h3 class="subsection__title">Staff</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Dr. Cindy (Xin) Dong, MD </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Assistant</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7011">604-675-8000 ext. 7011</a></div> <a href= "https://www.bccrc.ca/dept/et/contact/91" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-12/ET_DongLin.jpeg?itok=Bb8WfWjl" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Dr. Dong Lin, PhD, MD </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Staff Scientist</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext7011">604-675-8000 ext 7011</a></div> <a href= "https://www.bccrc.ca/dept/et/contact/102" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-12/ET_NelsonWong.jpeg?itok=ERSyVv7D" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Dr. Nelson Wong, PhD </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Staff Scientist </div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7622">604-675-8000 ext. 7622</a></div> <a href= "https://www.bccrc.ca/dept/et/contact/117" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-12/ET_RebeccaWu.jpeg?itok=uWvg3hrH" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Rebecca Wu </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Assistant</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7013">604-675-8000 ext. 7013</a></div> <a href= "https://www.bccrc.ca/dept/et/contact/119" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-12/ET_HuiXue.jpeg?itok=aCmQkLLw" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Dr. Hui Xue, MD </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Staff Scientist </div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7013">604-675-8000 ext. 7013</a></div> <a href= "https://www.bccrc.ca/dept/et/contact/120" class="more">Send message</a> </div> </section> </article> </div><h3 class="subsection__title">Post-Docs</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-12/ET_StephenChoi.jpeg?itok=2j1D-ql2" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Dr. Stephen Choi, PhD </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Post Doctoral Fellow</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7021">604-675-8000 ext. 7021</a></div> <a href= "https://www.bccrc.ca/dept/et/contact/87" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Dr. Connie (Ning) Kang, PhD </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Post Doctoral Fellow</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7013">604-675-8000 ext. 7013</a></div> <a href= "https://www.bccrc.ca/dept/et/contact/404" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Dr. Takashi Matsuoka, PhD, MD </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Post Doctoral Fellow</div> </div> <div class="contact"> <a href= "https://www.bccrc.ca/dept/et/contact/452" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-12/ET_XiaojiaJenniferNiu.jpeg?itok=8HQZCy5Z" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Dr. Jennifer Niu, PhD </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Post Doctoral Fellow</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7021">604-675-8000 ext. 7021</a></div> <a href= "https://www.bccrc.ca/dept/et/contact/105" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Dr. Fiona Zhang, PhD </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Post Doctoral Fellow</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7010">604-675-8000 ext. 7010</a></div> <a href= "https://www.bccrc.ca/dept/et/contact/124" class="more">Send message</a> </div> </section> </article> </div><h3 class="subsection__title">Students/Trainees</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Adam Classen </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">PhD Student </div> </div> <div class="contact"> <a href= "https://www.bccrc.ca/dept/et/contact/449" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Claire Marie Dourieu </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student </div> </div> <div class="contact"> <a href= "https://www.bccrc.ca/dept/et/contact/450" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Zoe Maylin </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Post Doctoral Fellow</div> </div> <div class="contact"> <a href= "https://www.bccrc.ca/dept/et/contact/451" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/et/dept/et/sites/experimentaltherapeutics/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Yu Wang </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7011">604-675-8000 ext. 7011</a></div> <a href= "https://www.bccrc.ca/dept/et/contact/114" class="more">Send message</a> </div> </section> </article> </div></section> <section id="publications" class="layout layout__expanding layout__publications"><h2 class="section__title">Selected Publications</h2><button class="icon" data-expand></button><div class="field field--field_text"> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37556934" target="_blank" rel="bookmark">Establishment and validation of preclinical models of SMARCA4-inactivated and ARID1A/ARID1B co-inactivated dedifferentiated endometrial carcinoma.</a> </h2> <div class="field field--field_journal">Gynecologic oncology, 2023</div> <div class="field field--field_authors">Wong, Nelson K Y, Llaurado Fernandez, Marta, Kommoss, Felix K F, Praveen Kumar, Pooja, Kim, Hannah, Liu, Jiahui, Zhang, Guihua, Coatham, Mackenzie, Lin, Yen-Yi, Haegert, Anne M, Volik, Stanislav, Le Bihan, Stephane, Collins, Colin C, Fu, Yangxin, Postovit, Lynne M, von Deimling, Andreas, Wu, Rebecca, Xue, Hui, Wang, Yuzhuo, Köbel, Martin, Carey, Mark S, Lee, Cheng-Han</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37556934" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37347559" target="_blank" rel="bookmark">Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth.</a> </h2> <div class="field field--field_journal">The Journal of clinical investigation, 2023</div> <div class="field field--field_authors">Gritsina, Galina, Fong, Ka-Wing, Lu, Xiaodong, Lin, Zhuoyuan, Xie, Wanqing, Agarwal, Shivani, Lin, Dong, Schiltz, Gary E, Beltran, Himisha, Corey, Eva, Morrissey, Colm, Wang, Yuzhuo, Zhao, Jonathan C, Hussain, Maha, Yu, Jindan</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37347559" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37075872" target="_blank" rel="bookmark">Malignant function of nuclear factor-kappaB axis in prostate cancer: Molecular interactions and regulation by non-coding RNAs.</a> </h2> <div class="field field--field_journal">Pharmacological research, 2023</div> <div class="field field--field_authors">Al-Rashidi, Reyadh R, Noraldeen, Sara Abdalrazzaq M, Kareem, Ali Kamil, Mahmoud, Aisha Kamal, Kadhum, Wesam R, Ramírez-Coronel, Andrés Alexis, Iswanto, Acim Heri, Obaid, Rasha Fadhel, Jalil, Abduladheem Turki, Mustafa, Yasser Fakri, Nabavi, Noushin, Wang, Yuzhuo, Wang, Lin</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37075872" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37452083" target="_blank" rel="bookmark">Influence of ADT on B7-H3 expression during CRPC progression from hormone-naïve prostate cancer.</a> </h2> <div class="field field--field_journal">Cancer gene therapy, 2023</div> <div class="field field--field_authors">Kang, Ning, Xue, Hui, Lin, Yen-Yi, Dong, Xin, Classen, Adam, Wu, Rebecca, Jin, Yuxuan, Lin, Dong, Volik, Stanislav, Ong, Christopher, Gleave, Martin, Collins, Colin, Wang, Yuzhuo</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37452083" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/36650259" target="_blank" rel="bookmark">The future of patient-derived xenografts in prostate cancer research.</a> </h2> <div class="field field--field_journal">Nature reviews. Urology, 2023</div> <div class="field field--field_authors">Lawrence, Mitchell G, Taylor, Renea A, Cuffe, Georgia B, Ang, Lisa S, Clark, Ashlee K, Goode, David L, Porter, Laura H, Le Magnen, Clémentine, Navone, Nora M, Schalken, Jack A, Wang, Yuzhuo, van Weerden, Wytske M, Corey, Eva, Isaacs, John T, Nelson, Peter S, Risbridger, Gail P</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/36650259" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37025467" target="_blank" rel="bookmark">Genomic alterations in neuroendocrine prostate cancer: A systematic review and meta-analysis.</a> </h2> <div class="field field--field_journal">BJUI compass, 2023</div> <div class="field field--field_authors">Chen, Junru, Shi, Mingchen, Chuen Choi, Stephen Yiu, Wang, Yu, Lin, Dong, Zeng, Hao, Wang, Yuzhuo</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37025467" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/36928314" target="_blank" rel="bookmark">RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis.</a> </h2> <div class="field field--field_journal">The Journal of clinical investigation, 2023</div> <div class="field field--field_authors">Wang, Mu-En, Chen, Jiaqi, Lu, Yi, Bawcom, Alyssa R, Wu, Jinjin, Ou, Jianhong, Asara, John M, Armstrong, Andrew J, Wang, Qianben, Li, Lei, Wang, Yuzhuo, Huang, Jiaoti, Chen, Ming</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/36928314" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37323470" target="_blank" rel="bookmark">A personalized mRNA vaccine has exhibited potential in the treatment of pancreatic cancer.</a> </h2> <div class="field field--field_journal">Holistic integrative oncology, 2023</div> <div class="field field--field_authors">Kang, Ning, Zhang, Si, Wang, Yuzhuo</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37323470" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/36351060" target="_blank" rel="bookmark">Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer.</a> </h2> <div class="field field--field_journal">Cancer research, 2023</div> <div class="field field--field_authors">Chou, Jonathan, Egusa, Emily A, Wang, Sinan, Badura, Michelle L, Lee, Fei, Bidkar, Anil P, Zhu, Jun, Shenoy, Tanushree, Trepka, Kai, Robinson, Troy M, Steri, Veronica, Huang, Jiaoti, Wang, Yuzhuo, Small, Eric J, Chan, Emily, Stohr, Bradley A, Ashworth, Alan, Delafontaine, Brant, Rottey, Sylvie, Cooke, Keegan S, Hashemi Sadraei, Nooshin, Yu, Brian, Salvati, Mark, Bailis, Julie M, Feng, Felix Y, Flavell, Robert R, Aggarwal, Rahul</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/36351060" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/36358940" target="_blank" rel="bookmark">Druggable Metabolic Vulnerabilities Are Exposed and Masked during Progression to Castration Resistant Prostate Cancer.</a> </h2> <div class="field field--field_journal">Biomolecules, 2022</div> <div class="field field--field_authors">Choi, Stephen Y C, Ribeiro, Caroline Fidalgo, Wang, Yuzhuo, Loda, Massimo, Plymate, Stephen R, Uo, Takuma</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/36358940" target="_blank">Learn More</a></div> 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href="https://www.ncbi.nlm.nih.gov/pubmed/29441566" target="_blank" rel="bookmark">Aneustat (OMN54) has aerobic glycolysis-inhibitory activity and also immunomodulatory activity as indicated by a first-generation PDX prostate cancer model.</a> </h2> <div class="field field--field_journal">International journal of cancer, 2018</div> <div class="field field--field_authors">Qu, Sifeng, Xue, Hui, Dong, Xin, Lin, Dong, Wu, Rebecca, Nabavi, Noushin, Collins, Colin C, Gleave, Martin E, Gout, Peter W, Wang, Yuzhuo</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/29441566" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29757368" target="_blank" rel="bookmark">The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications.</a> </h2> <div class="field field--field_journal">GigaScience, 2018</div> <div class="field field--field_authors">Ramnarine, Varune Rohan, Alshalalfa, Mohammed, Mo, Fan, Nabavi, Noushin, Erho, Nicholas, Takhar, Mandeep, Shukin, Robert, Brahmbhatt, Sonal, Gawronski, Alexander, Kobelev, Maxim, Nouri, Mannan, Lin, Dong, Tsai, Harrison, Lotan, Tamara L, Karnes, R Jefferey, Rubin, Mark A, Zoubeidi, Amina, Gleave, Martin E, Sahinalp, Cenk, Wyatt, Alexander W, Volik, Stanislav V, Beltran, Himisha, Davicioni, Elai, Wang, Yuzhuo, Collins, Colin C</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/29757368" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29544736" target="_blank" rel="bookmark">Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer.</a> </h2> <div class="field field--field_journal">European urology, 2018</div> <div class="field field--field_authors">Hao, Jun, Ci, Xinpei, Xue, Hui, Wu, Rebecca, Dong, Xin, Choi, Stephen Yiu Chuen, He, Haiqing, Wang, Yu, Zhang, Fang, Qu, Sifeng, Zhang, Fan, Haegert, Anne M, Gout, Peter W, Zoubeidi, Amina, Collins, Colin, Gleave, Martin E, Lin, Dong, Wang, Yuzhuo</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/29544736" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29487201" target="_blank" rel="bookmark">Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer.</a> </h2> <div class="field field--field_journal">Cancer research, 2018</div> <div class="field field--field_authors">Ci, Xinpei, Hao, Jun, Dong, Xin, Choi, Stephen Y, Xue, Hui, Wu, Rebecca, Qu, Sifeng, Gout, Peter W, Zhang, Fang, Haegert, Anne M, Fazli, Ladan, Crea, Francesco, Ong, Christopher J, Zoubeidi, Amina, He, Housheng H, Gleave, Martin E, Collins, Colin C, Lin, Dong, Wang, Yuzhuo</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/29487201" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/28330676" target="_blank" rel="bookmark">Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer.</a> </h2> <div class="field field--field_journal">European urology, 2018</div> <div class="field field--field_authors">Mo, Fan, Lin, Dong, Takhar, Mandeep, Ramnarine, Varune Rohan, Dong, Xin, Bell, Robert H, Volik, Stanislav V, Wang, Kendric, Xue, Hui, Wang, Yuwei, Haegert, Anne, Anderson, Shawn, Brahmbhatt, Sonal, Erho, Nicholas, Wang, Xinya, Gout, Peter W, Morris, James, Karnes, R Jeffrey, Den, Robert B, Klein, Eric A, Schaeffer, Edward M, Ross, Ashley, Ren, Shancheng, Sahinalp, S Cenk, Li, Yingrui, Xu, Xun, Wang, Jun, Wang, Jian, Gleave, Martin E, Davicioni, Elai, Sun, Yinghao, Wang, Yuzhuo, Collins, Colin C</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/28330676" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29381682" target="_blank" rel="bookmark">Treatment with docetaxel in combination with Aneustat leads to potent inhibition of metastasis in a patient-derived xenograft model of advanced prostate cancer.</a> </h2> <div class="field field--field_journal">British journal of cancer, 2018</div> <div class="field field--field_authors">Qu, Sifeng, Ci, Xinpei, Xue, Hui, Dong, Xin, Hao, Jun, Lin, Dong, Clermont, Pier-Luc, Wu, Rebecca, Collins, Colin C, Gout, Peter W, Wang, Yuzhuo</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/29381682" 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class="field field--field_authors">Kurita, T, Wang, Y Z, Donjacour, A A, Zhao, C, Lydon, J P, O'Malley, B W, Isaacs, J T, Dahiya, R, Cunha, G R</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/11313721" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/11800167" target="_blank" rel="bookmark">Estrogenic effects on prostatic differentiation and carcinogenesis.</a> </h2> <div class="field field--field_journal">Reproduction, fertility, and development, 2001</div> <div class="field field--field_authors">Cunha, G R, Wang, Y Z, Hayward, S W, Risbridger, G P</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/11800167" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/11150243" target="_blank" rel="bookmark">Evidence that epithelial and mesenchymal estrogen receptor-alpha mediates effects of estrogen on prostatic epithelium.</a> </h2> <div class="field field--field_journal">Developmental biology, 2001</div> <div class="field field--field_authors">Risbridger, G, Wang, H, Young, P, Kurita, T, Wang, Y Z, Lubahn, D, Gustafsson, J A, Cunha, G, Wong, Y Z</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/11150243" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/11085521" target="_blank" rel="bookmark">Sex hormone-induced carcinogenesis in Rb-deficient prostate tissue.</a> </h2> <div class="field field--field_journal">Cancer research, 2000</div> <div class="field field--field_authors">Wang, Y, Hayward, S W, Donjacour, A A, Young, P, Jacks, T, Sage, J, Dahiya, R, Cardiff, R D, Day, M L, Cunha, G R</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/11085521" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/11006573" target="_blank" rel="bookmark">Changes in serum and tissue zinc levels in sex hormone-induced prostatic carcinogenesis in the noble rat.</a> </h2> <div class="field field--field_journal">Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine</div> <div class="field field--field_authors">Wong, Y C, Wang, Y Z, Lee, J S, Tam, N N, Lee, D</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/11006573" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/9582085" target="_blank" rel="bookmark">Sex hormone-induced prostatic carcinogenesis in the noble rat: the role of insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in the development of prostate cancer.</a> </h2> <div class="field field--field_journal">The Prostate, 1998</div> <div class="field field--field_authors">Wang, Y Z, Wong, Y C</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/9582085" target="_blank">Learn More</a></div> </article> </div></section> <section id="projects" class="layout layout__expanding layout__projects"><h2 class="section__title">Projects</h2><button class="icon" data-expand></button><div class="field field--field_text"> <article class="node node--project teaser"> <div class="node__inner"> <h2 class="node__title"> <a href="/dept/et/projects/stromal-gene-expression-predicts-and-may-drive-metastasis-prostate-cancer" rel="bookmark" ><span>Stromal Gene Expression Predicts And May Drive Metastasis in Prostate Cancer</span> </a> </h2> <div class="field field--body"><p>Men with low to intermediate risk prostate cancer (PCa) face vexing decisions regarding treatment. The tumour can remain indolent and will not impact the patient within his lifetime, or it can progress to become life threatening (metastatic tumour). A holy grail of PCa research is the identification of prognostic biomarkers, which are biological factors that are associated with the disease outcomes, that can be used to improve patient risk stratification at time of diagnosis and guide treatment decisions.</p></div> <ul class="links inline"><li class="node-readmore"><a href="/dept/et/projects/stromal-gene-expression-predicts-and-may-drive-metastasis-prostate-cancer" rel="tag" title="Stromal Gene Expression Predicts And May Drive Metastasis in Prostate Cancer" hreflang="en">More Info<span class="visually-hidden"> about Stromal Gene Expression Predicts And May Drive Metastasis in Prostate Cancer</span></a></li></ul> </div> </article> <article class="node node--project teaser"> <div class="node__inner"> <h2 class="node__title"> <a href="/dept/et/projects/application-antibody-internalization-domain-improve-efficacy-and-safety-antibody-drug" rel="bookmark" ><span>Application of antibody internalization domain to improve the efficacy and safety of Antibody Drug Conjugates</span> </a> </h2> <div class="field field--body"><p>Recent revolution in anti-cancer therapy utilizes the antibody's power to target cancer cells with chemotoxins. This approach of conjugating toxin to antibody (ADC= antibody drug conjugates) with specific affinity to cancer cells have dramatically improved both the safety and efficacy of the treatment. The most notable recent success is Kadcyla which combines DM1 toxin with anti-HER2 antibody to treat breast cancer. A critical factor in developing a successful ADC is an antibody's ability to internalize itself once it binds to the target cancer cell's biomarkers (receptors).</p></div> <ul class="links inline"><li class="node-readmore"><a href="/dept/et/projects/application-antibody-internalization-domain-improve-efficacy-and-safety-antibody-drug" rel="tag" title="Application of antibody internalization domain to improve the efficacy and safety of Antibody Drug Conjugates" hreflang="en">More Info<span class="visually-hidden"> about Application of antibody internalization domain to improve the efficacy and safety of Antibody Drug Conjugates</span></a></li></ul> </div> </article> <article class="node node--project teaser"> <div class="node__inner"> <h2 class="node__title"> <a href="/dept/et/projects/identification-hp1a-key-regulator-and-novel-therapeutic-target-neuroendocrine-prostate" rel="bookmark" ><span>Identification of HP1a as a key regulator and a novel therapeutic target for neuroendocrine prostate cancer</span> </a> </h2> <div class="field field--body"><p>Neuroendocrine prostate cancer (NEPC) is a currently incurable, lethal subtype of prostate cancer that can develop from the disease following prolonged hormonal therapy. Unfortunately, there are few treatment options available for NEPC and new therapeutic targets and more effective treatments are urgently needed to improve its management. A state-of-the-art pre-clinical model of NEPC, developed in our group, is giving us unprecedented levels of accuracy in monitoring how NEPC progresses.</p></div> <ul class="links inline"><li class="node-readmore"><a href="/dept/et/projects/identification-hp1a-key-regulator-and-novel-therapeutic-target-neuroendocrine-prostate" rel="tag" title="Identification of HP1a as a key regulator and a novel therapeutic target for neuroendocrine prostate cancer" hreflang="en">More Info<span class="visually-hidden"> about Identification of HP1a as a key regulator and a novel therapeutic target for neuroendocrine prostate cancer</span></a></li></ul> </div> </article> <article class="node node--project teaser"> <div class="node__inner"> <h2 class="node__title"> <a href="/dept/et/projects/function-and-therapeutic-potential-suv420h2-neuroendocrine-prostate-cancer" rel="bookmark" ><span>Function and therapeutic potential of SUV420H2 in neuroendocrine prostate cancer</span> </a> </h2> <div class="field field--body"><p>Treatment-resistant neuroendocrine prostate cancer (NEPC) is a currently incurable, lethal subtype of prostate cancer that usually develops following prolonged hormonal therapy. The only treatment option for NEPC is a highly toxic chemotherapy, which provides only limited survival benefits. Therefore, more effective treatments are urgently needed to improve the management of NEPC. Our current research goal is to understand how NEPC develops and progresses and pave the road to develop new therapy for the disease treatment.</p></div> <ul class="links inline"><li class="node-readmore"><a href="/dept/et/projects/function-and-therapeutic-potential-suv420h2-neuroendocrine-prostate-cancer" rel="tag" title="Function and therapeutic potential of SUV420H2 in neuroendocrine prostate cancer" hreflang="en">More Info<span class="visually-hidden"> about Function and therapeutic potential of SUV420H2 in neuroendocrine prostate cancer</span></a></li></ul> </div> </article> </div></section> </section> </div> </section> </div> <a class="top" href="#main-content">Back to top</a> </main> <section class="region region__cta"> <div class="region__cta--inner region--inner"> <section id="block-sitecalltoaction" class="block block--block-contenta8a59224-4648-42d5-b71c-294b3c630d8a block-sitecalltoaction"> <div class="field field--body"><p>BC Cancer Foundation is the fundraising partner of BC Cancer, which includes BC Cancer Research. Together with our donors, we are changing cancer outcomes for British Columbians by funding innovative research and personalized treatment and care.</p> <p><a class="button" href="https://bccancerfoundation.com/donations/general-donation-form/?s_src=BCCRCFooter" target="_blank">Donate Today</a></p></div> </section> </div> </section> <footer class="page" role="contentinfo"> <section class="region region__footer"> <div class="region__footer--inner region--inner"> <section id="block-bccrc-branding" class="block block--system-branding-block block-bccrc-branding"> <a href="/dept/et/" title="Home" rel="home"> <img src="/dept/et/sites/experimentaltherapeutics/files/BCClogo_Research_ExperimentalTherapeutics_RGB.png" alt="Home" /> </a> </section> <section id="block-contactus" class="block block--block-content2314a90f-9af6-4a1e-8cf5-6a294688e075 block--contact-us block-contactus"> <h2 class="section__title">Contact Us</h2> <div class="field field--body"><p>BC Cancer Research Institute<br> 675 West 10th Avenue<br> Vancouver, BC V5Z 1L3</p> <p>604 675 8000</p> <p>Toll Free: 1 888 675 8001</p></div> </section> <section id="block-followus" class="block block--block-content06fb6d8a-948b-4134-bf4f-c16a4f797215 block--follow-us block-followus"> <h2 class="section__title">Follow Us</h2> <div class="field field--body"><p><a class="fa fa-linkedin" href="https://www.linkedin.com/company/bc-cancer/"> </a><a class="fa fa-twitter" href="https://twitter.com/BCCancer"> </a><a class="fa fa-instagram" href="https://www.instagram.com/bccancer/"> </a></p></div> </section> <section id="block-phsa" class="block block--block-content288c07b1-9e42-46f4-a804-fdd18540fbad block-phsa"> <div class="field field--body"><p><a href="http://www.phsa" target="_blank"><img alt="PHSA" src="https://www.bccrc.ca/dept/et/sites/experimentaltherapeutics/files/PHSA-logo.svg"></a></p></div> </section> </div> </section> </footer> <section class="region region__copyright"> <div class="region__copyright--inner region--inner"> <nav role="navigation" aria-labelledby="block-bccrc-footer-menu" id="block-bccrc-footer"> <h2 class="visually-hidden" id="block-bccrc-footer-menu">Footer menu</h2> <ul class="menu"> <li class="menu-item"> <a href="http://www.phsa.ca/privacy">Privacy Policy</a> </li> <li>Copyright © BC Cancer. 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