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KEGG DRUG: Nimesulide
<!doctype html> <html><head> <title>KEGG DRUG: Nimesulide</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1742697527"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1742697527"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1742697527" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; 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form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="650"><tr><td width=70><a href="/kegg/drug"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg5.gif"></a></td><td> </td><td><a name="drug:D01049"></a><font class="title5">DRUG: Nimesulide</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_drug.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/entry/" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr5 w1"> <table width="650" class="w2"> <tr><th class="th50 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td50 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">D01049 Drug <br> </span></code></td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td51 defd"><div class="cel">Nimesulide (JAN/INN)</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Formula</span></th> <td class="td50 defd"><div class="cel">C13H12N2O5S<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Exact mass</span></th> <td class="td51 defd"><div class="cel">308.0467<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Mol weight</span></th> <td class="td50 defd"><div class="cel">308.31<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Structure</span></th> <td class="td51 defd"><a href="/Fig/drug/D01049.gif"><img name="img0" src="/Fig/drug/D01049.gif" style="max-width:600px" border=0></a><br> <button class="btn" onclick="location.href='/entry/-f+m+D01049';return false;">Mol file</button><button class="btn" onclick="location.href='/entry/-f+k+D01049';return false;">KCF file</button><button class="btn" onclick="location.href='https://www.genome.jp/tools-bin/strsearch_view?ENTRY=D01049&PROGRAM=simcomp&DATABASE=drug';return false;">DB search</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td50 defd"><div class="cel"><span class="nowrap">Anti-inflammatory<br> <a href="/entry/DG01504">DG01504</a> Nonsteroidal anti-inflammatory drug (NSAID)<br> </span></div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Remark</span></th> <td class="td51 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ATC code: </span></td><td><a href="/brite/br08303+D01049">M01AX17 M02AA26</a></td></tr></table></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Efficacy</span></th> <td class="td50 defd"><div class="cel">Analgesic, Anti-inflammatory, Antipyretic, COX-2 inhibitor</div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Comment</span></th> <td class="td51 defd"><div class="cel">Sulfonamide derivative<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Target</span></th> <td class="td50 defd"><div class="cel">PTGS2 (COX2) [HSA:<a href="/entry/hsa:5743">5743</a>] [KO:<a href="/entry/K11987">K11987</a>]</div></td></tr> <tr><th class="th51 rept tal vtop"><span class="nowrap"> Pathway</span></th> <td class="td51 repd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa00590+5743">hsa00590</a> </span></td><td>Arachidonic acid metabolism</td></tr></table></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Interaction</span></th> <td class="td50 defd"><div class="cel"><button class="btn" onclick="location.href='/kegg-bin/ddi_list?drug=D01049';return false;">DDI search</button></div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td51 defd"><div class="cel"><span class="nowrap">Anatomical Therapeutic Chemical (ATC) classification [BR:<a href="/brite/br08303+D01049">br08303</a>]<br> M MUSCULO-SKELETAL SYSTEM<br> M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS<br> M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS<br> M01AX Other antiinflammatory and antirheumatic agents, non-steroids<br> M01AX17 Nimesulide<br> D01049 Nimesulide (JAN/INN)<br> M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN<br> M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN<br> M02AA Antiinflammatory preparations, non-steroids for topical use<br> M02AA26 Nimesulide<br> D01049 Nimesulide (JAN/INN)<br> Drug groups [BR:<a href="/brite/br08330+D01049+DG01504">br08330</a>]<br> Anti-inflammatory<br> DG01504 Nonsteroidal anti-inflammatory drug (NSAID)<br> D01049 Nimesulide<br> Target-based classification of drugs [BR:<a href="/brite/br08310+D01049">br08310</a>]<br> Enzymes<br> Oxidoreductases (EC1)<br> Prostaglandin synthase<br> PTGS2 (COX2)<br> D01049 Nimesulide (JAN/INN)<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=D01049';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CAS: </span></td><td>51803-78-2</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PubChem: </span></td><td><a href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7848112">7848112</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ChEBI: </span></td><td><a href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:44445">44445</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PDB-CCD: </span></td><td><a href="https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/NIM">NIM</a>[<a href="https://pdbj.org/mine/summary/NIM">PDBj</a>] </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">LigandBox: </span></td><td><a href="http://www.mypresto5.com/ligandbox202210/cgi-bin/liginf.cgi?id=D01049&source=KEGG_DRUG">D01049</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">NIKKAJI: </span></td><td><a href="https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J12.917H">J12.917H</a></td></tr></table></td></tr> <tr><th class="th51 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td51 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?drug+D01049';return false;">All DBs</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">KCF data</span></th> <td class="td50 defd"><button class="btn" id="kcfb1">Show</button><div class="kcfd" id="kcfd1"><br>ATOM 21<br> 1 C8y C 25.6724 -16.9148<br> 2 C8x C 25.6724 -18.3147<br> 3 C8y C 26.8886 -19.0112<br> 4 C8x C 28.0978 -18.3147<br> 5 C8x C 28.0978 -16.9148<br> 6 C8y C 26.8886 -16.2114<br> 7 C8x C 20.8395 -16.9217<br> 8 C8x C 20.8395 -18.3217<br> 9 C8x C 22.0556 -19.0181<br> 10 C8x C 23.2648 -18.3217<br> 11 C8y C 23.2648 -16.9217<br> 12 C8x C 22.0556 -16.2183<br> 13 O2a O 24.4695 -16.2114<br> 14 N1b N 26.8752 -14.8114<br> 15 S4a S 28.0853 -14.1079<br> 16 C1a C 29.2953 -13.3972<br> 17 O3c O 28.7817 -15.3179<br> 18 O3c O 27.3817 -12.8907<br> 19 N2b N 26.8752 -20.4112 #+<br> 20 O3a O 25.5883 -21.1775 #-<br> 21 O3a O 28.0853 -21.1146<br> BOND 22<br> 1 9 10 2<br> 2 10 11 1<br> 3 11 12 2<br> 4 12 7 1<br> 5 6 1 1<br> 6 11 13 1<br> 7 13 1 1<br> 8 6 14 1<br> 9 1 2 2<br> 10 14 15 1<br> 11 2 3 1<br> 12 15 16 1<br> 13 3 4 2<br> 14 15 17 2<br> 15 4 5 1<br> 16 15 18 2<br> 17 5 6 2<br> 18 3 19 1<br> 19 7 8 2<br> 20 19 20 1<br> 21 8 9 1<br> 22 19 21 2<br> </div></td></tr> </table></td></tr></table> <br><span style="font-size:12px"><a href="/entry/dr_ja:D01049">» Japanese version</a> <a href="javascript:history.back();">» Back</a></span><br><br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>