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class="h pbm"> <h1 class="ph"> 类风湿关节炎个体化治疗的新方法 <a href="https://blog.sciencenet.cn/blog.php?mod=recommend"><img src="./static/image/blog/recommendico.gif" width="22px" height="22px" /><font style="font-size:14px; color:#930;" face="宋体">精选</font></a> </h1> <p class="xg2"> <span class="xg1">已有 4075 次阅读</span> <span class="xg1">2024-11-21 19:37</span> <span class="pipe">|</span><span class="xg1">个人分类:<a href="https://blog.sciencenet.cn/home.php?mod=space&uid=212210&do=blog&classid=152747&view=me">健康生活</a></span><span class="pipe">|</span><span class="xg1">系统分类:<a href="https://blog.sciencenet.cn/home.php?mod=space&do=blog&view=all&uid=212210&catid=2">海外观察</a></span> </p> </div> <div id="blog_article" class="d cl" ><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">类风湿关节炎个体化治疗的新方法</span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">诸平</span></p><p style="text-align:center"><a href="https://www.meduniwien.ac.at/web/en/about-us/news/2024/news-in-november-2024/new-approach-to-personalized-treatment-of-rheumatoid-arthritis/" target="_self" target="_blank"><img src="http://bbs.sciencenet.cn/home.php?mod=attachment&filename=%CD%BC%C6%AC.png&id=1365825" title="" alt="图片.png" style="width: 507px; height: 346px;" height="346" width="507"/></a></p><p style="text-align:center"><a href="https://www.myscience.org/en/news/2024/new_approach_to_personalized_treatment_of_rheumatoid_arthritis-2024-meduniwien" target="_self" target="_blank"><img src="http://image.sciencenet.cn/home/202411/21/193232halll0t8a03y0th7.jpg" title="" alt="image.jpg"/></a></p><p style="text-align: center; line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;">(<a href="https://www.myscience.org/en/news/2024/new_approach_to_personalized_treatment_of_rheumatoid_arthritis-2024-meduniwien" target="_self" target="_blank">© Image: Depositphotos</a>)</span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">据奥地利维也纳医科大学</span><span style="font-size: 18px; font-family: times new roman;">（</span><a href="https://www.myscience.org/directory/medical_research/austria/meduniwien" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Medical University of Vienna</span></a><span style="font-size: 18px; font-family: 宋体,SimSun;">简称</span><a href="https://www.meduniwien.ac.at/web/en/about-us/news/2024/news-in-november-2024/new-approach-to-personalized-treatment-of-rheumatoid-arthritis/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank"><span style="font-size: 18px; font-family: times new roman;">MedUni Vienna</span></a><span style="font-size: 18px; font-family: times new roman;">, Vienna, Austria<span style="font-size: 18px; font-family: 宋体;">）</span>2024<span style="font-size: 18px; font-family: 宋体;">年</span>11<span style="font-size: 18px; font-family: 宋体;">月</span>21<span style="font-size: 18px; font-family: 宋体;">日提供的消息，类风湿关节炎个体化治疗的新方法（</span></span><a href="https://www.meduniwien.ac.at/web/en/about-us/news/2024/news-in-november-2024/new-approach-to-personalized-treatment-of-rheumatoid-arthritis/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank"><span style="font-size: 18px; font-family: times new roman;">New approach to personalized treatment of rheumatoid arthritis</span></a><span style="font-size: 18px; font-family: times new roman;">）。</span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;"><span style="font-size: 18px; font-family: 宋体;">目前有大量有效的药物可用于治疗类风湿性关节炎</span>(rheumatoid arthritis)<span style="font-size: 18px; font-family: 宋体;">，但到目前为止，还缺乏合适的策略来为个体患者选择最佳的治疗方法。</span></span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;"><span style="font-size: 18px; font-family: 宋体;">在维也纳医科大学医学第三医学系</span>(Department of Medicine III at </span><a href="https://www.meduniwien.ac.at/web/en/about-us/news/2024/news-in-november-2024/new-approach-to-personalized-treatment-of-rheumatoid-arthritis/" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank"><span style="font-size: 18px; font-family: times new roman;">MedUni Vienna</span></a><span style="font-size: 18px; font-family: times new roman;">)<span style="font-size: 18px; font-family: 宋体;">主任、风湿病学家丹尼尔·阿莱塔哈（</span>Daniel Aletaha<span style="font-size: 18px; font-family: 宋体;">）领导的一项全面科学审查中，现已开发出一个模型，重点关注患者的个人需求及其健康状况。这项研究于</span>2024<span style="font-size: 18px; font-family: 宋体;">年</span>10<span style="font-size: 18px; font-family: 宋体;">月</span>24<span style="font-size: 18px; font-family: 宋体;">日已经《自然评论</span>-<span style="font-size: 18px; font-family: 宋体;">风湿病》（</span></span><a href="https://www.nature.com/articles/s41584-024-01169-7" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Nature Reviews Rheumatology</span></a><span style="font-size: 18px; font-family: times new roman;">）<span style="font-size: 18px; font-family: 宋体,SimSun;">杂志网站发表</span>——</span><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Konzett+V&cauthor_id=39448800" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Victoria Konzett</span></a><span style="font-size: 18px; font-family: times new roman;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Aletaha+D&cauthor_id=39448800" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Daniel Aletaha</span></a><span style="font-size: 18px; font-family: times new roman;">. Management strategies in rheumatoid arthritis. Nature Reviews Rheumatology, 2024, <strong>20</strong>: 760–769. DOI: </span><a href="https://doi.org/10.1038/s41584-024-01169-7" target="_blank" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank"><span style="font-size: 18px; font-family: times new roman;">10.1038/s41584-024-01169-7.</span></a><span style="font-size: 18px; font-family: times new roman;"> Published: 24 October 2024. </span><a href="https://www.nature.com/articles/s41584-024-01169-7" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank"><span style="font-size: 18px; font-family: times new roman;">https://www.nature.com/articles/s41584-024-01169-7</span></a></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;"><span style="font-size: 18px; font-family: 宋体;">丹尼尔·阿莱塔哈（</span>Daniel Aletaha<span style="font-size: 18px; font-family: 宋体;">）解释说：“当然，在临床实践中已经尽可能多地考虑到个体类风湿性关节炎患者的情况和偏好。”然而，到目前为止，类风湿关节炎（</span>rheumatoid arthritis<span style="font-size: 18px; font-family: 宋体;">简称</span>RA<span style="font-size: 18px; font-family: 宋体;">）的治疗缺乏必要的科学“形式化”来系统地追求这种综合和全面的精准医学方法。丹尼尔·阿莱塔哈和合著者维多利亚·康泽特（</span>Victoria Konzett<span style="font-size: 18px; font-family: 宋体;">）共同开发的概念系统可以弥补这一差距。它包括对参数的考虑，这些参数可以在简单的医疗咨询中获得，然后可以进行评估并用于更准确地做出治疗决定。</span></span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;"><strong><span style="font-size: 18px; font-family: 宋体;">“治疗匹配”（</span> <a href="https://www.meduniwien.ac.at/web/en/about-us/news/2024/news-in-november-2024/new-approach-to-personalized-treatment-of-rheumatoid-arthritis/" target="_self" target="_blank">"Therapeutic matchmaking"</a></strong><strong><span style="font-size: 18px; font-family: 宋体;">）</span></strong><strong><span style="font-size: 18px; font-family: 宋体;"></span></strong></span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;"><span style="font-size: 18px; font-family: 宋体;">丹尼尔·阿莱塔哈说：“今天，我们有多种治疗类风湿性关节炎的药物，所有这些药物都很有效。然而，药物的关键区别不在于它们的疗效，而在于它们对个体患者的安全性。”例如，对类风湿关节炎并伴有心力衰竭的患者的最佳治疗可能与对复发性带状疱疹的类风湿性关节炎患者的最佳治疗不同。单独优化处理的这些和其他组件在模型中以结构化的方式呈现。它在临床实践中的应用可能会导致一个作者称之为“治疗匹配”（</span> "therapeutic matchmaking"<span style="font-size: 18px; font-family: 宋体;">）的过程。在这个过程中，医生和患者就一种既有效又安全的治疗方法达成一致。</span></span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">丹尼尔·阿莱塔哈澄清说：“精准医疗显然不仅仅是选择对个人最有效的药物。”他认为，将治疗药物的安全性、待治疗患者的多病情况以及患者的偏好纳入治疗决策，可以显著改善患者的治疗效果，提高患者的生活质量。</span></p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: 宋体,SimSun;">上述介绍，仅供参考。欲了解更多信息，敬请注意浏览</span><a href="https://www.nature.com/articles/s41584-024-01169-7" style="text-decoration: underline; font-size: 18px; font-family: 宋体,SimSun;" target="_blank"><span style="font-size: 18px; font-family: 宋体,SimSun;">原文</span></a><span style="font-size: 18px; font-family: 宋体,SimSun;">或者</span><a href="https://www.meduniwien.ac.at/web/en/about-us/news/2024/news-in-november-2024/new-approach-to-personalized-treatment-of-rheumatoid-arthritis/" style="text-decoration: underline; font-size: 18px; font-family: 宋体,SimSun;" target="_blank"><span style="font-size: 18px; font-family: 宋体,SimSun;">相关报道</span></a><span style="font-size: 18px; font-family: 宋体,SimSun;">。</span></p><p style="line-height: 2em;"><a href="https://www.nature.com/articles/s41584-024-01169-7" style="text-decoration: underline; font-size: 18px; font-family: times new roman;" target="_blank"><span style="font-size: 18px; font-family: times new roman;">Abstract</span></a> </p><p style="line-height: 2em;"><span style="font-size: 18px; font-family: times new roman;">Management of rheumatoid arthritis (RA) has evolved from simply the direct translation of drug efficacy results from clinical trials to patient care, to a more complex longitudinal process that considers not only drug efficacy but also the safety gestalt of a treatment and patient profiles and preferences, as well as health-economic factors. With numerous DMARDs available to treat RA, knowledge about trial efficacy becomes less important than data that inform an appropriate clinical strategy for their optimal selection and use. Overly ambitious approaches targeting the 'maximum' level of success could, for example, be prone to failure and create frustration, and lead to a large number of patients then being considered as 'difficult to treat'. Safety profiles might be more informative than efficacy profiles for precision medicine approaches. Contemporary RA management strategies might therefore take a more holistic approach, beyond merely efficacy, to the setting of targets that lead to improved compliance rather than aspirational successes, with consideration of each patient's multimorbidity profile and preferences, as well as the safety profile of each treatment. Ultimately, the goal remains unchanged: maximizing health-related quality of life; however, with a focus on optimal balance rather than superlatives.</span></p> <br /><br /> <label style="font-size:13px; color:#850f0f">转载本文请联系原作者获取授权，同时请注明本文来自诸平科学网博客。<br />链接地址：</label><a href="https://blog.sciencenet.cn/blog-212210-1461053.html" target="_blank" style="font-size:13px; color:#850f0f">https://blog.sciencenet.cn/blog-212210-1461053.html </a> <br /><br />上一篇：<a href='blog-212210-1460916.html' target='_black'>为何Nature同日连发同一研究小组的三篇论文？</a><br />下一篇：<a href='blog-212210-1461217.html' target='_black'>自然疗法可以逆转阿尔茨海默病的症状</a>  </div> <div id="click_div"><table cellpadding="0" cellspacing="0" class="atd"> <tr></tr> </table> <script type="text/javascript"> function errorhandle_clickhandle(message, values) { if(values['id']) { showCreditPrompt(); show_click(values['idtype'], values['id'], values['clickid']); } } </script> </div> <div class="o cl">   <div id="shareblog"></div>  <a href="https://blog.sciencenet.cn/home.php?mod=spacecp&ac=favorite&type=blog&id=1461053&spaceuid=212210&handlekey=favoritebloghk_1461053" id="a_favorite" onclick="showWindow(this.id, this.href, 'get', 0);" class="oshr ofav">收藏</a>  IP: 111.20.218.*<span class="pipe">|</span> <a href="https://blog.sciencenet.cn/home.php?mod=spacecp&ac=blog&blogid=1461053&op=edithot&handlekey=bloghothk_1461053" id="blog_hot_1461053" onclick="showWindow(this.id, this.href, 'get', 0);">热度</a><span class="pipe">|</span>  </div> </div> <div class="ct_vw cl">  <div> <div id="div_main_content" class="mbm">  <h4 class="bbs pbn"> <span><label>当前推荐数：</label><font color="#FF0000" id="recommendcount">1</font> <label style="margin-left:10px;" id="recommendtag">推荐人：</label> <span id="recommendbody"> <a href="https://blog.sciencenet.cn/home.php?mod=space&uid=437607" style="margin-right:5px; 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