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Structural Biology | SPT Labtech
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data-hs-cos-type="module"> <div class="application-banner image" style="background-image: url('https://www.sptlabtech.com/hubfs/Website/04%20-%20Structural%20Biology/Structural-Biology---hero.jpg')"> <div class="overlay"> <div class="grey-overlay"> <div class="container"> <div class="breadcrumb-container"> <ol class="breadcrumb custom-breadcrumb"> <li class="breadcrumb-item" data="1"><a href="/">Home</a></li> <li class="breadcrumb-item"> Structural Biology </li> </ol> </div> </div> <div class="container"> <div class="flex"> <div class="application-bnr-text medium"> <div class="text-block"> <h1 class="title-symbol">Structural <br>Biology</h1> <div id="hs_cos_wrapper_widget_1629795891799_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="banner_content.description"><p><span>The dynamic field of structural biology investigates the molecular structure of biological macromolecules to understand fundamental life processes and tackle disease.</span></p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-3 main_area-row-1-padding main_area-row-1-max-width-section-centering dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-4 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1631270309708" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1631270309708_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2>New techniques are revolutionizing structural biology</h2> <p>New technological advances and techniques in Cryo-EM and protein crystallography have inspired a structural biology revolution, enabling researchers to tackle even more complex biological problems to benefit scientific research. ‘Integrative’ structural biology brings together multiple approaches to build a more comprehensive picture of dynamic processes at both a cellular and molecular level.</p></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-5 dnd-section"> <div class="row-fluid "> <div 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text-right"> <div class="anchor-point" id="electron-microscopy"> <i> <img src="https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=98&height=98&name=microscope-icon.png" alt="microscope-icon" loading="loading=" "" width="98" height="98" srcset="https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=49&height=49&name=microscope-icon.png 49w, https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=98&height=98&name=microscope-icon.png 98w, https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=147&height=147&name=microscope-icon.png 147w, https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=196&height=196&name=microscope-icon.png 196w, https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=245&height=245&name=microscope-icon.png 245w, https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=294&height=294&name=microscope-icon.png 294w" sizes="(max-width: 98px) 100vw, 98px"> </i> <h3>Transmission electron <br>microscopy</h3> <p>Transmission electron microscopy is a promising and adaptable technique providing researchers with valuable insights on intricate biological structures ranging from individual biomolecules to whole cells.</p> <a href="/products?application-area=Structural+biology" class="btn"> Explore related products </a> </div> </div> </div> </div> </div> </div> </div> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-6 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <!--Sub Application Module 2--> <div class="sub-application-module"> <div class="container bullet-list-points"> <div class="sub-app-inr" style="background:rgba(244, 247, 249,1.0"> <div class="sub-app-module2"> <div class="anchor-point" id="sub-application-module"> <div class="sub-app-module2-inr"> <div class="row"> <div class="col-md-6"> <div class="sub-module2-content text-center"> <i> <img src="https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=98&height=98&name=microscope-icon.png" alt="microscope-icon" loading="" width="98" height="98" srcset="https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=49&height=49&name=microscope-icon.png 49w, https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=98&height=98&name=microscope-icon.png 98w, https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=147&height=147&name=microscope-icon.png 147w, https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=196&height=196&name=microscope-icon.png 196w, https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=245&height=245&name=microscope-icon.png 245w, https://www.sptlabtech.com/hs-fs/hubfs/Website/00%20-%20Reusable%20Assets/icons/microscope-icon.png?width=294&height=294&name=microscope-icon.png 294w" sizes="(max-width: 98px) 100vw, 98px"> </i> <h3><strong>Cryo-Electron </strong><br>Microscopy (Cryo-EM)</h3> <p>Cryo-EM has ushered in a new era of scientific discovery with the production of increasingly higher-resolution structural information. Advances in hardware and software have now opened up the technique to more widespread adoption in basic research and drug discovery.</p> <a href="https://www.sptlabtech.com/applications/structural-biology/cryo-em" class="btn"> Learn more </a> </div> </div> <div class="col-md-6"> <div class="sub-module2-content text-center"> <i> <img src="https://www.sptlabtech.com/hubfs/Website/00%20-%20Reusable%20Assets/icons/protein-icon.png" alt="protein-icon" loading="lazy" style="max-width: 100%; height: auto;"> </i> <h3><strong>Single Particle </strong><br>Analysis</h3> <p>Single particle analysis (SPA) is a well-established cryo-electron microscopy technique, allowing structural biologists to investigate the detailed structures of macromolecules at near-atomic resolution to uncover rich biological insights.</p> <a href="/products?sub-application=Single+Particle+Analysis" class="btn"> Explore related products </a> </div> </div> <div class="col-md-6"> <div class="sub-module2-content text-center"> <i> <img src="https://www.sptlabtech.com/hubfs/Website/00%20-%20Reusable%20Assets/icons/molecule-icon.png" alt="molecule-icon" loading="lazy" style="max-width: 100%; height: auto;"> </i> <h3><strong>Cryo-Tomography</strong></h3> <p>Cryo-electron tomography (cryo-ET) uses 3D molecular-level imaging to produce high-resolution structural and spatial information about individual proteins and the cellular environment where they operate.</p> <a href="https://www.sptlabtech.com/products/quantifoil" class="btn" target="_blank" rel="noopener"> Explore our range of quantifoil products </a> </div> </div> <div class="col-md-6"> <div class="sub-module2-content text-center"> <i> <img src="https://www.sptlabtech.com/hubfs/Website/00%20-%20Reusable%20Assets/icons/doc-with-magnify-icon.png" alt="doc-with-magnify-icon" loading="lazy" style="max-width: 100%; height: auto;"> </i> <h3><strong>Micro Electron Diffraction</strong></h3> <p>Micro electron diffraction (MicroED) is a developing technique for determining the structure of proteins from nanocrystals bringing together cryo-EM sample preparation approaches with electron and X-ray crystallography data analytics.</p> <a href="https://www.sptlabtech.com/products/quantifoil" class="btn"> Explore our range of quantifoil products </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <!--Sub Application Module 2--> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-7 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_main_area-module-5" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="sub-application-module"> <div class="container bullet-list-points"> <div class="sub-app-inr" style="background:rgba(255, 255, 255,1.0)"> <div class="sub-app-module1"> <div class="row img-position d-flex "> <div class="col-md-6"> <a href="/products?sub-application=Protein+Crystallography"> <div class="sub-app-module-img"> <img src="https://www.sptlabtech.com/hubfs/Website/04%20-%20Structural%20Biology/Protein_Structure.jpg" alt="Protein_Structure" loading="lazy" style="max-width: 100%; height: auto;"> </div> </a> </div> <div class="col-md-6 d-flex align-items-center bullet-list-points"> <div class="sub-module-content "> <div class="anchor-point" id="protein-crystallography"> <i> <img src="https://www.sptlabtech.com/hubfs/3d-sell-icon.svg" alt="3d-sell-icon" loading="loading=" lazy"" style="max-width: 100%; height: auto;"> </i> <h3>Protein crystallography</h3> <p>The automation of protein crystallography screening has made a significant contribution to the rapid expansion of crystallography-based structural biology. Obtaining crystals of a high enough resolution for X-ray diffraction studies can be time and cost intensive, requiring an extensive number of screening and optimization experiments to determine ideal conditions for crystal growth.</p> <a href="https://www.sptlabtech.com/applications/structural-biology/protein-crystallography" class="btn"> Learn more </a> </div> </div> </div> </div> </div> </div> </div> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-8 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <!--Sub Application Module 2--> <div class="sub-application-module"> <div class="container bullet-list-points"> <div class="sub-app-inr" style="background:rgba(255, 255, 255,1.0"> <div class="sub-app-module2"> <div class="anchor-point" id="sub-application-module"> <div class="sub-app-module2-inr"> <div class="row"> <div class="col-md-6"> <div class="sub-module2-content text-center"> <i> <img src="https://www.sptlabtech.com/hubfs/Website/00%20-%20Reusable%20Assets/icons/resources-icon-poster.png" alt="resources-icon-poster" loading="lazy" style="max-width: 100%; height: auto;"> </i> <h3><strong>Protein crystallography methods</strong></h3> <p>Protein crystallography encompasses a range of techniques such as vapor diffusion and batch crystallization methods to deliver protein structure data in dynamic research environments. Agile solutions are needed to allow researchers to adapt approaches between multiple projects.</p> <a href="https://www.sptlabtech.com/applications/structural-biology/protein-crystallography" class="btn"> Check out all methods </a> </div> </div> <div class="col-md-6"> <div class="sub-module2-content text-center"> <i> <img src="https://www.sptlabtech.com/hubfs/Website/00%20-%20Reusable%20Assets/icons/graph-icon.png" alt="graph-icon" loading="lazy" style="max-width: 100%; height: auto;"> </i> <h3><strong>Crystal screen </strong><br> optimization</h3> <p>Optimizing protein crystallization hits to improve diffraction can be onerous. 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