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}) })(jQuery); </script> </head> <body class="post-template-default single single-post postid-1151 single-format-standard header-image full-width-content genesis-breadcrumbs-visible"><div class="site-container"><header class="site-header"><div class="wrap"><div class="title-area"><p class="site-title"><a href="https://www.thermofisher.com/" title="Thermo Fisher Scientific">Thermo Fisher Scientific</a></p><p class="site-description">Electron and cryo-electron microscopy stories and solutions about the advancement of cellular and structural biology</p></div><div class="widget-area header-widget-area"><section id="block-5" class="widget widget_block"><div class="widget-wrap"> <div class="wp-block-group"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"></div></div> </div></section> <section id="block-6" class="widget widget_block"><div class="widget-wrap"> <div class="wp-block-group"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"></div></div> </div></section> </div><div class="breadcrumb"><span class="breadcrumb-link-wrap"><a href="https://www.thermofisher.com/blog/?">Accelerating Science</a></span><span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/atomic-resolution/"><span class="breadcrumb-link-text-wrap">Life in Atomic Resolution</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/atomic-resolution/cryo-electron-microscopy-cryo-em/"><span class="breadcrumb-link-text-wrap">Cryo-Electron Microscopy (Cryo-EM)</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-current-title">New York Structural Biology Center Broadens Access to Cryo-EM</span></div></div></header> <section class="hero-banner" style="background-image:url(https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2023/08/1920x800-Tundra-Ed-Eng-Blog-surface.png)"> </section> <div class="site-inner"><div class="content-sidebar-wrap"><main class="content"><article class="post-1151 post type-post status-publish format-standard has-post-thumbnail category-cryo-electron-microscopy-cryo-em category-customer-spotlights category-general tag-cryo-electron-microscopy tag-cryo-em tag-cryo-em-single-particle-analysis tag-transmission-electron-microscope tag-tundra-cryo-tem entry" aria-label="New York Structural Biology Center Broadens Access to Cryo-EM"><header class="entry-header"><h1 class="entry-title">New York Structural Biology Center Broadens Access to Cryo-EM</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/author/alexilitchev/" title="Posts by Alex Ilitchev" rel="author">Alex Ilitchev</a> </span> <span class="post-info-date"> 07.25.2023 </span> </header><div class="entry-content"><h2 style="font-size: 100%"><strong>National cryo-EM facilities democratize cryo-electron microscopy</strong></h2> <p><a href="https://ter.li/b9dpcu">Cryo-electron microscopy</a> (cryo-EM) is revolutionizing structural biology, bringing new insights, and bridging observations made by other structural analysis techniques. A number of shared facilities and national centers around the world are providing cryo-EM education, often at little to no cost, thus driving the adoption of this powerful technique. Additionally, cryo-EM instrumentation is constantly improving, meaning that <a href="https://www.thermofisher.com/blog/atomic-resolution/cryo-tem-transmission-electron-microscopy-simplified/">even lower-kV cryo-electron microscopes are now capable of generating valuable structural insights</a>.</p> <h2 style="font-size: 100%"><strong>Cryo-EM at the New York Structural Biology Center</strong></h2> <p>One of the facilities seeking to broaden access to cryo-EM is the <a href="https://nysbc.org/">New York Structural Biology Center</a> (NYSBC), a non-profit facility in New York City which provides its members access to advanced structural biology resources, including cryo-EM instruments and training. It’s also part of a system of <a href="https://www.cryoemcenters.org/cryoem-centers/">National Cryo-EM Centers</a>, supported by the NIH Common Fund. We spoke with Edward Eng, Ph.D., Senior Scientist and Manager at the NYSBC about their efforts to increase cryo-EM access and create a sustainable cryo-EM ecosystem.</p> <p><iframe title="Tundra Cryo-TEM increases accessibilty to cryo-electron microscopy" width="760" height="428" src="https://www.youtube.com/embed/9LOQxkt4OOU?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p> <p>“A key part of what we do here is educational outreach. The reason for that is because cryo-EM is an emerging technology. It hasn’t really stabilized. Every year, we keep on growing and developing new tools and we go to different fields,” said Eng. “The best way to create a sustainable ecosystem is to create cryo-EM champions, and that’s why we’re not just focusing on current scientists, but also scientists early in their careers who are interested in using cryo-EM as a technology.”</p> <div id="attachment_1162" style="width: 634px" class="wp-caption aligncenter"><img decoding="async" aria-describedby="caption-attachment-1162" class="wp-image-1162 size-full" title="Edward Eng, New York Structural Biology Center" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2023/08/Ed-Eng-front-of-NYSBC.jpg" alt="Edward Eng, New York Structural Biology Center" width="624" height="468" srcset="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2023/08/Ed-Eng-front-of-NYSBC.jpg 624w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2023/08/Ed-Eng-front-of-NYSBC-300x225.jpg 300w" sizes="(max-width: 624px) 100vw, 624px" /><p id="caption-attachment-1162" class="wp-caption-text">Edward Eng at the New York Structural Biology Center</p></div> <h2 style="font-size: 100%"><strong>The Cryo-EM Merit Badge</strong></h2> <p>One way the New York Structural Biology Center is promoting cryo-EM education is through the Cryo-EM Merit Badge Program, which is provided across all U.S. National Centers for Cryo-EM. This program offers a standardized set of training that ensures badge recipients are well versed in the core fundamentals of cryo-EM, from sample preparation to data processing. Badges are honored across all national centers and reduce the need for duplicate training.</p> <p>As Eng notes; “The Cryo-EM Merit Badge program is a proficiency program. It allows the centers to cross-train and cross-certify users. We’ve noticed that many researchers, once trained at a national center, want to go home with protocols and best practices, and the Merit Badge Program provides that framework for them.” This program also offers Merit Badges for select cryo-EM tools, and Eng shared that a Merit Badge for the operation of the Tundra Cryo-TEM is in progress.</p> <h2 style="font-size: 100%"><strong>Increasing demand for more accessible cryo-EM instrumentation</strong></h2> <p>With the growing popularity of cryo-EM, research institutions may have questions regarding resources and physical space needed to support the technique. Eng notes how the <a href="https://ter.li/mnpe5n">Thermo Scientific Tundra Cryo-TEM</a> specifically has appeared as an attractive option for many of these institutions.</p> <p>“One of the reasons why we are really excited about [the Tundra Cryo-TEM] is that it is helping democratize cryo-EM… It has a lot of functionality, and we foresee a lot of low-resource institutions coming in and making use of that form factor. It has been one of the most highly utilized training tools that we have at our center.” Regarding the introduction of a new detector option and its impact, Eng noted “The availability of the Falcon C [detector] for the Tundra Cryo-TEM will be game changing. So not only [can] the Tundra [Cryo-TEM be used] as a screening microscope, but [as] a data collection tool. And that versatility is great for institutions that may only have one TEM.”</p> <div id="attachment_1158" style="width: 510px" class="wp-caption aligncenter"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-1158" class="wp-image-1158" title="Edward Eng with the Thermo Scientific Tundra Cryo-TEM at New York Structural Biology Center" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2023/08/Ed-Eng-with-sample-loader.jpg" alt="Edward Eng with the Thermo Scientific Tundra Cryo-TEM at New York Structural Biology Center" width="500" height="667" srcset="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2023/08/Ed-Eng-with-sample-loader.jpg 624w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2023/08/Ed-Eng-with-sample-loader-225x300.jpg 225w" sizes="(max-width: 500px) 100vw, 500px" /><p id="caption-attachment-1158" class="wp-caption-text">Thermo Scientific Tundra Cryo-TEM</p></div> <h2 style="font-size: 100%"><strong>Training the next generation of cryo-EM experts at the New York Structural Biology Center</strong></h2> <p>Fundamentally, it’s clear that the future of cryo-EM depends on the community that is forming around this technique. It will rely not only on the current generation of cryo-EM experts, but also new researchers and students who are just becoming familiar with the technique.</p> <p>“I think that’s very important, not just in terms of outreach in other fields and getting people interested in cryo-EM, but we have to create that ecosystem,” Eng notes. “Our future operators, our future directors, our future scientists will be our former trainees and users. If we don’t do a great job training them now, then I don’t know how sustainable and scalable we will be.”</p> <p>National centers, such as the New York Structural Biology Center, are creating a vital foundation on which this technique, and its capabilities, can flourish.</p> <p>Eng noted that cryo-EM is a great field for young scientists and advised that they not be afraid to jump in, even as the technology continues to evolve. ““There’s a lot of support. The National Center Program is here and will be here for a long time.”</p> <p><a href="https://ter.li/mnpe5n"><em>Learn more about the Thermo Scientific Tundra Cryo-TEM</em></a></p> <p><a href="https://ter.li/3eej7j"><img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1336" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2023/10/Optin-Banner_Oct-2023-v2.png" alt="Subscribe to electron microscopy updates and content from Thermo Fisher Scientific" width="1000" height="176" srcset="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2023/10/Optin-Banner_Oct-2023-v2.png 1000w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2023/10/Optin-Banner_Oct-2023-v2-300x53.png 300w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2023/10/Optin-Banner_Oct-2023-v2-768x135.png 768w" sizes="(max-width: 1000px) 100vw, 1000px" /></a></p>  <div 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