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Thymic hypoplasia: Difference between revisions - Wikipedia

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It allows adding a reason in the summary.">undo</a></span></strong></div><div id="mw-diff-ntitle2"><a href="/wiki/User:Boghog" class="mw-userlink" title="User:Boghog" data-mw-revid="1129891359"><bdi>Boghog</bdi></a> <span class="mw-usertoollinks">(<a href="/wiki/User_talk:Boghog" class="mw-usertoollinks-talk" title="User talk:Boghog">talk</a> | <a href="/wiki/Special:Contributions/Boghog" class="mw-usertoollinks-contribs" title="Special:Contributions/Boghog">contribs</a>)</span><div class="mw-diff-usermetadata"><div class="mw-diff-userroles"><a href="/wiki/Wikipedia:Autopatrolled" title="Wikipedia:Autopatrolled">Autopatrolled</a>, <a href="/wiki/Wikipedia:Extended_confirmed_editors" class="mw-redirect" title="Wikipedia:Extended confirmed editors">Extended confirmed users</a>, <a href="/wiki/Wikipedia:IP_block_exemption" title="Wikipedia:IP block exemption">IP block exemptions</a>, <a href="/wiki/Wikipedia:New_pages_patrol/Reviewers" title="Wikipedia:New pages patrol/Reviewers">New page reviewers</a>, <a href="/wiki/Wikipedia:Reviewing_pending_changes" title="Wikipedia:Reviewing pending changes">Pending changes reviewers</a>, <a href="/wiki/Wikipedia:Rollback" title="Wikipedia:Rollback">Rollbackers</a>, <a href="/wiki/Wikipedia:Template_editor" title="Wikipedia:Template editor">Template editors</a></div><div class="mw-diff-usereditcount"><span>137,126</span> edits</div></div></div><div id="mw-diff-ntitle3"> <span class="comment comment--without-parentheses">consistent citation formatting</span></div><div id="mw-diff-ntitle5"></div><div id="mw-diff-ntitle4"> </div></td> </tr><tr><td colspan="4" class="diff-multi" lang="en">(4 intermediate revisions by 2 users not shown)</td></tr><tr> <td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>{{Infobox <del class="diffchange diffchange-inline">disease</del></div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>{{Infobox <ins class="diffchange diffchange-inline">medical condition (new)</ins></div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">Name</del> = Thymic hypoplasia</div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">name</ins> = Thymic hypoplasia</div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">Image </del> = </div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">synonyms</ins> = </div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">Alt </del> = </div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">image</ins> = </div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">Caption</del> = </div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">alt </ins> = </div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">DiseasesDB</del> = <del class="diffchange diffchange-inline">34516</del></div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">caption </ins> = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| pronounce = </div></td> </tr> <tr> <td class="diff-marker"><a class="mw-diff-movedpara-left" title="Paragraph was moved. Click to jump to new location." href="#movedpara_12_6_rhs">&#x26AB;</a></td> <td class="diff-deletedline diff-side-deleted"><div><a name="movedpara_2_0_lhs"></a>| ICD10 = Q89.2 (note: thymus is classified as [[endocrine]] in ICD-10)</div></td> <td colspan="2" class="diff-empty diff-side-added"></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">ICD9 </del> = <del class="diffchange diffchange-inline">{{ICD9|759.2}}</del></div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">field</ins> = </div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">ICDO </del> = </div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">symptoms</ins> = </div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">OMIM </del> = </div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">complications</ins> = </div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">MedlinePlus</del> = </div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">onset </ins> = </div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">eMedicineSubj</del> = </div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">duration </ins> = </div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">eMedicineTopic</del> = </div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">types </ins> = </div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>| <del class="diffchange diffchange-inline">MeshID</del> = </div></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| <ins class="diffchange diffchange-inline">causes</ins> = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| risks = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| diagnosis = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| differential = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| prevention = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| treatment = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| medication = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| prognosis = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| frequency = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| deaths = </div></td> </tr> <tr> <td class="diff-marker"></td> <td class="diff-context diff-side-deleted"><div>}}</div></td> <td class="diff-marker"></td> <td class="diff-context diff-side-added"><div>}}</div></td> </tr> <tr> <td class="diff-marker"></td> <td class="diff-context diff-side-deleted"><div>'''Thymic hypoplasia''' is a condition where the [[thymus]] is underdeveloped or involuted.</div></td> <td class="diff-marker"></td> <td class="diff-context diff-side-added"><div>'''Thymic hypoplasia''' is a condition where the [[thymus]] is underdeveloped or involuted.</div></td> </tr> <tr> <td class="diff-marker"></td> <td class="diff-context diff-side-deleted"><br /></td> <td class="diff-marker"></td> <td class="diff-context diff-side-added"><br /></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>==Causes==</div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>Calcium levels can be used to distinguish between the following two conditions associated with thymic hypoplasia:</div></td> <td colspan="2" class="diff-empty diff-side-added"></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>There are various causes of thymic hypoplasia such as [[22q11.2 deletion syndrome]], CHARGE syndrome, Nude/SCID and otofaciocervical syndrome type 2 (OTFCS2),&lt;ref&gt;{{cite journal | vauthors = Bhalla P, Wysocki CA, van Oers NS | title = Molecular Insights Into the Causes of Human Thymic Hypoplasia With Animal Models | journal = Frontiers in Immunology | volume = 11 | pages = 830 | date = May 2020 | pmid = 32431714 | pmc = 7214791 | doi = 10.3389/fimmu.2020.00830 | doi-access = free }}&lt;/ref&gt; and [[ataxia telangiectasia]].&lt;ref&gt;{{Cite book | vauthors = Taylor AM, Hernandez D, McConville CM, Woods CG, Stacey M, Biggs P, Byrd PJ, Arlett CF, Scott D | chapter = Malignant disease and variations in radiosensitivity in ataxia telangiectasia patients. | title = Genetic predisposition to cancer 1996 | year = 1996 | pages = 138–151 | publisher = Springer | location = Boston, MA |doi=10.1007/978-1-4899-4501-3_9 |isbn=978-0-412-56580-9 }}&lt;/ref&gt;</div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>* [[22q11.2 deletion syndrome]]: [[hypocalcemia]]</div></td> <td colspan="2" class="diff-empty diff-side-added"></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td class="diff-deletedline diff-side-deleted"><div>* [[Ataxia telangiectasia]]: normal levels of calcium</div></td> <td colspan="2" class="diff-empty diff-side-added"></td> </tr> <tr> <td class="diff-marker"></td> <td class="diff-context diff-side-deleted"><br /></td> <td class="diff-marker"></td> <td class="diff-context diff-side-added"><br /></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>== References ==</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>{{Reflist}}</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><br /></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>== External links ==</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>{{Medical resources</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| DiseasesDB = 34516</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker"><a class="mw-diff-movedpara-right" title="Paragraph was moved. Click to jump to old location." href="#movedpara_2_0_lhs">&#x26AB;</a></td> <td class="diff-addedline diff-side-added"><div><a name="movedpara_12_6_rhs"></a>|<ins class="diffchange diffchange-inline"> </ins> ICD10 = Q89.2 (note: thymus is classified as [[endocrine]] in ICD-10)</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| ICD9 = {{ICD9|759.2}}</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| ICDO = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| OMIM = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| MedlinePlus = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| eMedicineSubj = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| eMedicineTopic = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>| MeshID = </div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td class="diff-addedline diff-side-added"><div>}}</div></td> </tr> <tr> <td class="diff-marker"></td> <td class="diff-context diff-side-deleted"><div>{{endocrine-disease-stub}}</div></td> <td class="diff-marker"></td> <td class="diff-context diff-side-added"><div>{{endocrine-disease-stub}}</div></td> </tr> <tr> <td class="diff-marker"></td> <td class="diff-context diff-side-deleted"><div>{{Congenital lymphatic organ disorders}}</div></td> <td class="diff-marker"></td> <td class="diff-context diff-side-added"><div>{{Congenital lymphatic organ disorders}}</div></td> </tr> </table><hr class='diff-hr' id='mw-oldid' /> <h2 class='diff-currentversion-title'>Latest revision as of 16:32, 27 December 2022</h2> <div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Thymic hypoplasia</th></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Medical_genetics" title="Medical genetics">Medical genetics</a>&#160;<span class="penicon autoconfirmed-show"><span class="mw-valign-text-top" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q7799616?uselang=en#P1995" title="Edit this on Wikidata"><img alt="Edit this on Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></td></tr></tbody></table> <p><b>Thymic hypoplasia</b> is a condition where the <a href="/wiki/Thymus" title="Thymus">thymus</a> is underdeveloped or involuted. </p> <div class="mw-heading mw-heading2"><h2 id="Causes">Causes</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Thymic_hypoplasia&amp;action=edit&amp;section=1" title="Edit section: Causes"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>There are various causes of thymic hypoplasia such as <a href="/wiki/22q11.2_deletion_syndrome" class="mw-redirect" title="22q11.2 deletion syndrome">22q11.2 deletion syndrome</a>, CHARGE syndrome, Nude/SCID and otofaciocervical syndrome type 2 (OTFCS2),<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> and <a href="/wiki/Ataxia_telangiectasia" class="mw-redirect" title="Ataxia telangiectasia">ataxia telangiectasia</a>.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Thymic_hypoplasia&amp;action=edit&amp;section=2" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output 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.citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFBhallaWysockivan_Oers2020" class="citation journal cs1">Bhalla P, Wysocki CA, van Oers NS (May 2020). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214791">"Molecular Insights Into the Causes of Human Thymic Hypoplasia With Animal Models"</a>. <i>Frontiers in Immunology</i>. <b>11</b>: 830. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3389%2Ffimmu.2020.00830">10.3389/fimmu.2020.00830</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214791">7214791</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/32431714">32431714</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Frontiers+in+Immunology&amp;rft.atitle=Molecular+Insights+Into+the+Causes+of+Human+Thymic+Hypoplasia+With+Animal+Models&amp;rft.volume=11&amp;rft.pages=830&amp;rft.date=2020-05&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7214791%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F32431714&amp;rft_id=info%3Adoi%2F10.3389%2Ffimmu.2020.00830&amp;rft.aulast=Bhalla&amp;rft.aufirst=P&amp;rft.au=Wysocki%2C+CA&amp;rft.au=van+Oers%2C+NS&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7214791&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AThymic+hypoplasia" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTaylorHernandezMcConvilleWoods1996" class="citation book cs1">Taylor AM, Hernandez D, McConville CM, Woods CG, Stacey M, Biggs P, Byrd PJ, Arlett CF, Scott D (1996). "Malignant disease and variations in radiosensitivity in ataxia telangiectasia patients.". <i>Genetic predisposition to cancer 1996</i>. Boston, MA: Springer. pp.&#160;138–151. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2F978-1-4899-4501-3_9">10.1007/978-1-4899-4501-3_9</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-0-412-56580-9" title="Special:BookSources/978-0-412-56580-9"><bdi>978-0-412-56580-9</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=bookitem&amp;rft.atitle=Malignant+disease+and+variations+in+radiosensitivity+in+ataxia+telangiectasia+patients.&amp;rft.btitle=Genetic+predisposition+to+cancer+1996&amp;rft.place=Boston%2C+MA&amp;rft.pages=138-151&amp;rft.pub=Springer&amp;rft.date=1996&amp;rft_id=info%3Adoi%2F10.1007%2F978-1-4899-4501-3_9&amp;rft.isbn=978-0-412-56580-9&amp;rft.aulast=Taylor&amp;rft.aufirst=AM&amp;rft.au=Hernandez%2C+D&amp;rft.au=McConville%2C+CM&amp;rft.au=Woods%2C+CG&amp;rft.au=Stacey%2C+M&amp;rft.au=Biggs%2C+P&amp;rft.au=Byrd%2C+PJ&amp;rft.au=Arlett%2C+CF&amp;rft.au=Scott%2C+D&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AThymic+hypoplasia" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a 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style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q7799616" class="extiw" title="d:Q7799616">D</a></div><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/ICD-10" title="ICD-10">10</a></b>: Q89.2 (note: thymus is classified as <a href="/wiki/Endocrine" class="mw-redirect" title="Endocrine">endocrine</a> in ICD-10)</li><li><b><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/List_of_ICD-9_codes" title="List of ICD-9 codes">9-CM</a></b>: <a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=759.2">759.2</a></li><li><b><a href="/wiki/Diseases_Database" title="Diseases Database">DiseasesDB</a></b>: <a rel="nofollow" class="external text" href="http://www.diseasesdatabase.com/ddb34516.htm">34516</a></li></ul></div></div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1012311289">.mw-parser-output .asbox{position:relative;overflow:hidden}.mw-parser-output .asbox table{background:transparent}.mw-parser-output .asbox p{margin:0}.mw-parser-output .asbox p+p{margin-top:0.25em}.mw-parser-output .asbox-body{font-style:italic}.mw-parser-output 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<li><a href="/wiki/Thymus_hyperplasia" title="Thymus hyperplasia">Hyperplasia</a></li> <li><a class="mw-selflink selflink">Hypoplasia</a> <ul><li><a href="/wiki/DiGeorge_syndrome" title="DiGeorge syndrome">DiGeorge syndrome</a></li></ul></li> <li><a href="/wiki/Ectopic_thymus" title="Ectopic thymus">Ectopic thymus</a></li> <li><a href="/wiki/Thymoma" title="Thymoma">Thymoma</a></li> <li><a href="/wiki/Thymic_carcinoma" title="Thymic carcinoma">Thymic carcinoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Spleen#Clinical_significance" title="Spleen">Spleen</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Asplenia" title="Asplenia">Asplenia</a> <ul><li><a href="/wiki/Asplenia_with_cardiovascular_anomalies" title="Asplenia with cardiovascular anomalies">Asplenia with cardiovascular anomalies</a></li></ul></li> <li><a href="/wiki/Accessory_spleen" title="Accessory spleen">Accessory spleen</a></li> <li><a href="/wiki/Polysplenia" title="Polysplenia">Polysplenia</a></li> <li><a href="/wiki/Wandering_spleen" title="Wandering spleen">Wandering spleen</a></li> <li><a href="/wiki/Splenomegaly" title="Splenomegaly">Splenomegaly</a> <ul><li><a href="/wiki/Banti%27s_syndrome" title="Banti&#39;s syndrome">Banti's syndrome</a></li></ul></li> <li><a href="/wiki/Splenic_infarction" title="Splenic infarction">Splenic infarction</a></li> <li><a href="/wiki/Splenic_tumor" title="Splenic tumor">Splenic tumor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Lymph_node" title="Lymph node">Lymph node</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lymphadenopathy" title="Lymphadenopathy">Lymphadenopathy</a></li> <li><a href="/wiki/Generalized_lymphadenopathy" title="Generalized lymphadenopathy">Generalized lymphadenopathy</a></li> <li><a href="/wiki/Castleman%27s_disease" class="mw-redirect" title="Castleman&#39;s disease">Castleman's disease</a></li> <li><a href="/wiki/Intranodal_palisaded_myofibroblastoma" title="Intranodal palisaded myofibroblastoma">Intranodal palisaded myofibroblastoma</a></li> <li><a href="/wiki/Kikuchi_disease" title="Kikuchi disease">Kikuchi disease</a></li> <li><a href="/wiki/Tonsils" class="mw-redirect" title="Tonsils">Tonsils</a> <ul><li>see <a href="/wiki/Template:Respiratory_pathology" title="Template:Respiratory pathology">Template:Respiratory pathology</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Lymphatic_vessel" title="Lymphatic vessel">Lymphatic vessels</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lymphangitis" title="Lymphangitis">Lymphangitis</a></li> <li><a href="/wiki/Lymphangiectasia" title="Lymphangiectasia">Lymphangiectasia</a></li> <li><a href="/wiki/Lymphedema" title="Lymphedema">Lymphedema</a></li> <li><a href="/wiki/Primary_lymphedema" title="Primary lymphedema">Primary lymphedema</a> <ul><li><a href="/wiki/Congenital_lymphedema" class="mw-redirect" title="Congenital lymphedema">Congenital lymphedema</a></li> <li><a href="/wiki/Lymphedema_praecox" title="Lymphedema praecox">Lymphedema praecox</a></li> <li><a href="/wiki/Lymphedema_tarda" class="mw-redirect" title="Lymphedema tarda">Lymphedema tarda</a></li> <li><a href="/wiki/Lymphedema%E2%80%93distichiasis_syndrome" title="Lymphedema–distichiasis syndrome">Lymphedema–distichiasis syndrome</a></li> <li><a href="/wiki/Milroy%27s_disease" title="Milroy&#39;s disease">Milroy's disease</a></li></ul></li> <li><a href="/wiki/Secondary_lymphedema" title="Secondary lymphedema">Secondary lymphedema</a> <ul><li><a href="/wiki/Bullous_lymphedema" title="Bullous lymphedema">Bullous lymphedema</a></li> <li><a href="/wiki/Factitial_lymphedema" title="Factitial lymphedema">Factitial lymphedema</a></li> <li><a href="/wiki/Postinflammatory_lymphedema" title="Postinflammatory lymphedema">Postinflammatory lymphedema</a></li> <li><a href="/wiki/Postmastectomy_lymphangiosarcoma" class="mw-redirect" title="Postmastectomy lymphangiosarcoma">Postmastectomy lymphangiosarcoma</a></li></ul></li> <li><a href="/wiki/Waldmann_disease" title="Waldmann disease">Waldmann disease</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Lymphoid_and_complement_disorders_causing_immunodeficiency" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Lymphoid_and_complement_immunodeficiency" title="Template:Lymphoid and complement immunodeficiency"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Lymphoid_and_complement_immunodeficiency" title="Template talk:Lymphoid and complement immunodeficiency"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Lymphoid_and_complement_immunodeficiency" title="Special:EditPage/Template:Lymphoid and complement immunodeficiency"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Lymphoid_and_complement_disorders_causing_immunodeficiency" style="font-size:114%;margin:0 4em"><a href="/wiki/Lymphatic_system" title="Lymphatic system">Lymphoid</a> and <a href="/wiki/Complement_system" title="Complement system">complement</a> disorders causing <a href="/wiki/Immunodeficiency" title="Immunodeficiency">immunodeficiency</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Primary_immunodeficiency" title="Primary immunodeficiency">Primary</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Antibody" title="Antibody">Antibody</a>/<a href="/wiki/Humoral_immune_deficiency" title="Humoral immune deficiency">humoral</a><br />(<a href="/wiki/B_cell" title="B cell">B</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hypogammaglobulinemia" title="Hypogammaglobulinemia">Hypogammaglobulinemia</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/X-linked_agammaglobulinemia" title="X-linked agammaglobulinemia">X-linked agammaglobulinemia</a></li> <li><a href="/wiki/Transient_hypogammaglobulinemia_of_infancy" title="Transient hypogammaglobulinemia of infancy">Transient hypogammaglobulinemia of infancy</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Dysgammaglobulinemia" title="Dysgammaglobulinemia">Dysgammaglobulinemia</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Selective_immunoglobulin_A_deficiency" title="Selective immunoglobulin A deficiency">IgA deficiency</a></li> <li><a href="/wiki/IgG_deficiency" title="IgG deficiency">IgG deficiency</a></li> <li><a href="/wiki/Immunoglobulin_M_deficiency" class="mw-redirect" title="Immunoglobulin M deficiency">IgM deficiency</a></li> <li><a href="/wiki/Hyper_IgM_syndrome" title="Hyper IgM syndrome">Hyper IgM syndrome</a> (<a href="/wiki/Hyper-IgM_syndrome_type_1" title="Hyper-IgM syndrome type 1">1</a></li> <li><a href="/wiki/Hyper-IgM_syndrome_type_2" title="Hyper-IgM syndrome type 2">2</a></li> <li><a href="/wiki/Hyper-IgM_syndrome_type_3" title="Hyper-IgM syndrome type 3">3</a></li> <li><a href="/wiki/Hyper-IgM_syndrome_type_4" title="Hyper-IgM syndrome type 4">4</a></li> <li><a href="/wiki/Hyper-IgM_syndrome_type_5" title="Hyper-IgM syndrome type 5">5</a>)</li> <li><a href="/wiki/Wiskott%E2%80%93Aldrich_syndrome" title="Wiskott–Aldrich syndrome">Wiskott–Aldrich syndrome</a></li> <li><a href="/wiki/Hyperimmunoglobulin_E_syndrome" title="Hyperimmunoglobulin E syndrome">Hyper-IgE syndrome</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Common_variable_immunodeficiency" title="Common variable immunodeficiency">Common variable immunodeficiency</a></li> <li><a href="/wiki/ICF_syndrome" class="mw-redirect" title="ICF syndrome">ICF syndrome</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/T_cell_deficiency" title="T cell deficiency">T cell deficiency</a><br />(<a href="/wiki/T_cell" title="T cell">T</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a class="mw-selflink selflink">thymic hypoplasia</a>:</i> <i>hypoparathyroid</i> (<a href="/wiki/DiGeorge_syndrome" title="DiGeorge syndrome">Di George's syndrome</a>)</li> <li><i>euparathyroid</i> (<a href="/wiki/Nezelof_syndrome" title="Nezelof syndrome">Nezelof syndrome</a></li> <li><a href="/wiki/Ataxia%E2%80%93telangiectasia" title="Ataxia–telangiectasia">Ataxia–telangiectasia</a>)</li></ul> <p><i>peripheral:</i> <a href="/wiki/Purine_nucleoside_phosphorylase_deficiency" title="Purine nucleoside phosphorylase deficiency">Purine nucleoside phosphorylase deficiency</a> </p> <ul><li><a href="/wiki/Hyper_IgM_syndrome" title="Hyper IgM syndrome">Hyper IgM syndrome</a> (<a href="/wiki/Hyper-IgM_syndrome_type_1" title="Hyper-IgM syndrome type 1">1</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Severe_combined_immunodeficiency" title="Severe combined immunodeficiency">Severe</a> <a href="/wiki/Combined_immunodeficiencies" title="Combined immunodeficiencies">combined</a><br />(B+T)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>x-linked:</i> <a href="/wiki/X-linked_severe_combined_immunodeficiency" title="X-linked severe combined immunodeficiency">X-SCID</a><br /><i>autosomal:</i> <a href="/wiki/Adenosine_deaminase_deficiency" title="Adenosine deaminase deficiency">Adenosine deaminase deficiency</a></li> <li><a href="/wiki/Omenn_syndrome" title="Omenn syndrome">Omenn syndrome</a></li> <li><a href="/wiki/ZAP70_deficiency" title="ZAP70 deficiency">ZAP70 deficiency</a></li> <li><a href="/wiki/Bare_lymphocyte_syndrome" title="Bare lymphocyte syndrome">Bare lymphocyte syndrome</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Immunodeficiency#acquired" title="Immunodeficiency">Acquired</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIV/AIDS" title="HIV/AIDS">HIV/AIDS</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Leukopenia" title="Leukopenia">Leukopenia</a>:<br /><a href="/wiki/Lymphocytopenia" title="Lymphocytopenia">Lymphocytopenia</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Idiopathic_CD4%2B_lymphocytopenia" title="Idiopathic CD4+ lymphocytopenia">Idiopathic CD4+ lymphocytopenia</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Complement_deficiency" title="Complement deficiency">Complement<br />deficiency</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/C1-inhibitor" title="C1-inhibitor">C1-inhibitor</a></i> (<a href="/wiki/Angioedema" title="Angioedema">Angioedema</a>/<a href="/wiki/Hereditary_angioedema" title="Hereditary angioedema">Hereditary angioedema</a>)</li> <li><a href="/wiki/Complement_2_deficiency" title="Complement 2 deficiency">Complement 2 deficiency</a>/<a href="/wiki/Complement_4_deficiency" title="Complement 4 deficiency">Complement 4 deficiency</a></li> <li><a href="/wiki/MBL_deficiency" title="MBL deficiency">MBL deficiency</a></li> <li><a href="/wiki/Properdin_deficiency" title="Properdin deficiency">Properdin deficiency</a></li> <li><a href="/wiki/Complement_3_deficiency" title="Complement 3 deficiency">Complement 3 deficiency</a></li> <li><a href="/wiki/Terminal_complement_pathway_deficiency" title="Terminal complement pathway deficiency">Terminal complement pathway deficiency</a></li> <li><a href="/wiki/Paroxysmal_nocturnal_hemoglobinuria" title="Paroxysmal nocturnal hemoglobinuria">Paroxysmal nocturnal hemoglobinuria</a></li> <li><a href="/wiki/Complement_receptor_deficiency" class="mw-redirect" title="Complement receptor deficiency">Complement receptor deficiency</a></li></ul> </div></td></tr></tbody></table></div></div><!--esi <esi:include src="/esitest-fa8a495983347898/content" /> --><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Thymic_hypoplasia&amp;oldid=1129891359">https://en.wikipedia.org/w/index.php?title=Thymic_hypoplasia&amp;oldid=1129891359</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" 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