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as a Method * define function as object methods * @type {Object} */ window.digitalData = { user: {}, page: {}, merchandising: {}, getQueryParam : function (param) { var index, key, value, hash; var hashes = window.location.href.slice(window.location.href.indexOf('?') + 1).split('&'); for (index = 0; index < hashes.length; index++) { hash = hashes[index].split('='); key = hash[0]; value = hash[1]; if (key.toUpperCase() === param.toUpperCase()) return value; } return ''; }, getValOnce: function (value, cookieName, expiry, timeUnit) { var currentDate = new Date; var currentCookieValue; // timeUnit of 'm' is minutes represented in milliseconds // thus 86400000 = 24 hours = 1 day var interval = timeUnit == 'm' ? 60000 : 86400000; cookieName = cookieName ? cookieName : 'digitaldata_gvo'; value = value ? value : ''; expiry = expiry ? expiry : 0; currentCookieValue = this.getCookie(cookieName); if (value) { currentDate.setTime(currentDate.getTime() + expiry * interval); this.setCookie(cookieName, value, expiry == 0 ? 0 : currentDate); } return value == currentCookieValue ? '' : value; }, getCookie: function (key) { var result = ""; var cookies = document.cookie ? document.cookie.split('; ') : []; for (var i = 0; i < cookies.length; i++) { var parts = cookies[i].split('='); var name = decodeURIComponent(parts.shift()); var cookie = parts ? parts.join('=') : []; // Prevent storing or parsing of a cookie that we couldn't decode. if (cookie && key === name) { // removes surrounding quotes if (cookie.indexOf('"') === 0) { // This is a quoted cookie as according to RFC2068, unescape... cookie = cookie.slice(1, -1).replace(/\\"/g, '"').replace(/\\\\/g, '\\'); } // parse utf8 characters try { cookie = decodeURIComponent(cookie); } catch (e) {} result = cookie; // we found it, don't bother looking at other cookies break; } } return result; }, setCookie : function(name, value, numDays){ if ( !numDays ) numDays = 31; var expires = new Date(); expires.setTime(expires.getTime() + (1000 * 60 * 60 * 24 * numDays)); document.cookie = name+ '=' + escape(value) + '; path=/; expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }, /** * get the master domain based on business rules */ getMasterDomain : function () { // default the master domain var masterDomain = 'thermofisher.com'; // check for alternate domain portion of URL var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }, /** * Check if init has been initiated once * @type {Boolean} */ initted: false, /** * @return {Array} method returns an array of a given object's key properties */ init: function () { this.page.country = this.getCookie("CK_ISO_CODE") || 'us'; this.page.language = this.getCookie('CK_LANG_CODE') || 'en'; this.page.siteName = 'thermo'; //hard coded this.initMerchandisingData(); this.initUserData(); this.displayDigitalData(); this.formSubmitEvent(); }, //specific function to set type of the page // need specific function to keep page type separate from other page attributes setPageType: function (type) { this.setPageAttribute('type', type); }, // generic function to set page attributes setPageAttribute: function (key, value) { this.page[key] = value; }, // display digitalData object displayDigitalData: function () { }, // specific function to add an object to digitalData addDigitDataObject: function (key, object) { this[key] = object; }, addChildObjectAttribute: function(child, key, value){ this[child][key] = value; }, initUserData: function(){ var gigyaCookie = this.getCookie("identity_uid"); this.user.gigyaId = ""; this.user.loginStatus = "anonymous"; if( gigyaCookie != ""){ this.user.gigyaId = gigyaCookie; this.user.loginStatus = "logged in"; } }, /** * Check if init has been initiated once * @type {Boolean} */ merchandisingDataInitted: false, initMerchandisingData: function () { // read cid and icid value from session cookie this.merchandising.icid = this.getCookie('s_ev21_tc'); this.merchandising.cid = this.getCookie('s_cmp_tc'); // EMID value this.merchandising.emid = this.getQueryParam("emid"); // referrer by domain if (typeof document.referrer !== 'undefined' && document.referrer.length > 0) { var masterDomain = this.getMasterDomain(); var refReg = document.referrer; var referrerDomain = refReg.match(/:\/\/([^/]+)\//); if (referrerDomain !== null && referrerDomain[1].indexOf(masterDomain) == -1) { this.merchandising.referrer = referrerDomain; } } document.addEventListener('registerMerchandisingData', function (event) { for (var key in event.detail) { console.log("Listener data copied", key, event.detail[key] ); digitalData.merchandising[key] = event.detail[key]; } // Map some analytics attributes to merchandising session attributes digitalData.merchandising.sessionId = digitalData.merchandising.analyticsVisitorID; digitalData.merchandising.s_vi_low = digitalData.merchandising.analyticsVisitorIDLow; digitalData.merchandising.s_vi_high = digitalData.merchandising.analyticsVisitorIDHigh; console.log("digitalData: Captured registerMerchandisingData event"); digitalData.merchandisingDataInitted = true; // Call emailCampaignRecord if the digitalDataAnalyticsListener object is loaded if (typeof digitalDataAnalyticsListener != "undefined") { console.log("digitalData: Calling email campaign record"); digitalDataAnalyticsListener.emailCampaignRecord(); } }); }, formSubmitEvent: function () { var formId = this.getQueryParam("form-submit-id"); if ((formId) && formId !== "" && formId !== null) { var eventDetail = { detail: { form: { id: formId } } }; var formSubmitEvent = new CustomEvent('formSubmit', eventDetail); console.log('form submit event started'); document.dispatchEvent(formSubmitEvent); console.log('form submit event fired', eventDetail); //flush grepToken from Session Storage sessionStorage.removeItem('grepTokenSO'); } }, modalVideoEvent: function (videoId) { if (((videoId) && videoId !== "" && videoId !== null)) { var eventDetail = { detail: { video: { playerId: videoId } } }; var modalVideoEvent = new CustomEvent('videoPlayerLoaded', eventDetail); document.dispatchEvent(modalVideoEvent); } }, customClickEvent: function (clickDetail) { if (((clickDetail) && clickDetail !== "" && clickDetail !== null)) { var eventDetail = { detail: { CustomLink: { linkName: clickDetail } } } var customClickEvent = new CustomEvent('customLinkClicks', eventDetail); document.dispatchEvent(customClickEvent); } } } })(); window.digitalData.init(); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_25"); </script> <script type="text/javascript"> var localizedStrings = { "ACCEPTANCE": "Acceptance of Terms of Use", "BTN_AGREE": "Agree", "BTN_DISAGREE": "Disagree", "PROCESSING_MESSAGE" :"processing ... please wait ...", "ADD_TO_CART_QUANTITY_ERROR":"You must provide a quantity to add an item to the cart", "ADD_TO_CART_VALID_QUANTITY_ERROR":"You must provide a valid quantity to add an item to the cart", "VIEW_CART" :"View cart & checkout", "VIEW_CONTACT_DETAIL" :"View Contact Details", "ADD_TO_CART_NOTIFICATION":"Add to Cart Notification", "UPDATE_CART" :"Update Cart", "PRINCIPAL_INVESTIGATOR":"Principal Investigator", "PRINCIPAL_INVESTIGATOR_TEAM_LEADER":"Principal Investigator or Team Leader", "PRINCIPAL_INVESTIGATOR_CHIEF":"Principal Investigator or Chief", "EMAIL_ERROR_1" :"Please Provide Collegues Email", "EMAIL_ERROR_2" :"Please enter a valid colleague email address", "EMAIL_ERROR_3" :"Please Provide Your Email", "EMAIL_ERROR_4" :"Please enter a valid email address", "ERROR_OCCURED_MESSAGE" :"The following errors occured", "NEXT" :"Next", "PREVIOUS" :"Prev", "IMAGE" :"Image", "SAVE_TO_LIST_ERROR_1" :"Please enter a list name.", "SAVE_TO_LIST_ERROR_2" :"Please enter a different list name that does not include the following: ?,/,\\,%,^,!", "MINICART_ERROR_1" :"Unable to connect to eCommerce system. 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<div class="details-hero" ng-click="$ctrl.toggleImages('ADVANCED_VERIFICATION')"> <a class="link adv-verification-link animated-scroll" href="/sg/en/home/life-science/antibodies/invitrogen-antibody-validation.html"> <svg class="svg-icon advanced-verification-icon"> <use href="#icon-advanced-verification"></use> </svg> Advanced Verification </a> <p class="adv-verification-detail" onclick="window.THERMO_FISHER.pdp.inp.toggleImagesAdvVerificationSmLtr(event, this)"> This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. </p> </div> <div class="details-hero" onclick="window.THERMO_FISHER.pdp.inp.toggleImagesAdvVerificationPublishedFigures(event, this)"> <a class="link published-link animated-scroll " href="#image-gallery" onclick="window.THERMO_FISHER.pdp.inp.publishedFiguresHero(event, this)"> <svg class="svg-icon published-figures-icon"> <use href="#icon-published-figures"></use> </svg> 97 Published Figures </a> </div> <div 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A qRT-PCR analysis of crispld2 knockdown efficiency in hUCMSCs transfected with shRNA for the non-targeting sequence (shControl-hUCMSCs) or shRNA for the crispld2 sequence (shCrispld2-hUCMSCs). B The protein level of CRISPLD2 was detected by Western blot, full-length blots are presented in Additional file 4 : Fig. S3. C Quantitative analysis of the expression level of CRISPLD2 ( n \u003d 3). D qRT-PCR was performed to evaluate crispld2 mRNA expression in shCrispld2-hUCMSCs treated with EAC mouse serum ( n \u003d 3). E , F The proportion of CD4 + IL-4 + cells were analyzed by flow cytometry E and quantitative analysis F in different groups ( n \u003d 3). G , H CD4 + T cells were labeled with CFSE, and the proliferation of CD4 + T cells was analyzed by flow cytometry G and quantitative analysis H in different groups ( n \u003d 3). I The protein expression of phosphorylated and total STAT6 in CD4 + T cells was detected by Western blot, full-length blots are presented in Additional file 4 : Fig. S3. J Quantitative analysis of the expression level of p-STAT6 ( n \u003d 3). The data are expressed as mean +- SD, * P \u003c 0.05, ** P \u003c 0.01, and *** P \u003c 0.001','shortDescription':'Fig. 7 CRISPLD2 mediates hUCMSC repressing the differentiation of Th0 cells into Th2 cells. A qRT-PCR analysis of crispld2 knockdown efficiency in hUCMSCs transfected with shRNA for the non-targeting sequence (shControl-hUCMSCs) or shRNA for the crispld2 sequence (shCrispld2-hUCMSCs). B The protein level of CRISPLD2 was detected by Western blot, full-length blots are presented in Additional file 4 : Fig. S3... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Oct 2, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Stem cell research \u0026 therapy','journalText':'Stem cell research \u0026 therapy 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29057_13287_2023_3484_Fig7_HTML.jpg','benchSciPubmedId':'37784129'},{'sku':'11-0041-82','imageId':'1139014','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29057_13287_2023_3484_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29057_13287_2023_3484_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29057_13287_2023_3484_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29057_13287_2023_3484_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'4','description':'Fig. 3 hUCMSCs change CD4 + T lymphocyte subsets in CLNs that are detected by flow cytometry. A CD4 + T cells in CLNs were gated by flow cytometry. B The proportion of Th1, Th2, and Treg cells among CD4 + T cells in CLNs was analyzed by flow cytometry. C Quantitative analysis of the proportion of Th1, Th2, and Treg cells among CD4 + T cells ( n \u003d 3). The data are expressed as mean +- SD, * P \u003c 0.05, ** P \u003c 0.01','shortDescription':'Fig. 3 hUCMSCs change CD4 + T lymphocyte subsets in CLNs that are detected by flow cytometry. A CD4 + T cells in CLNs were gated by flow cytometry. B The proportion of Th1, Th2, and Treg cells among CD4 + T cells in CLNs was analyzed by flow cytometry. C Quantitative analysis of the proportion of Th1, Th2, and Treg cells among CD4 + T cells ( n \u003d 3). The data are expressed as mean +- SD, * P \u003c 0.05, ** P \u003c ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Oct 2, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Stem cell research \u0026 therapy','journalText':'Stem cell research \u0026 therapy 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29057_13287_2023_3484_Fig3_HTML.jpg','benchSciPubmedId':'37784129'},{'sku':'11-0041-82','imageId':'1139013','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29059_NRR-19-671-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29059_NRR-19-671-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29059_NRR-19-671-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29059_NRR-19-671-g004.jpg?time\u003d20240507','sortOrder':'5','description':'Fasudil-modified macrophages affect T cell polarization. A mouse model of chronic EAE was induced by subcutaneous injection of myelin oligodendrocyte glycoprotein peptde 35-55. Macrophages from EAE mice isolated with magnetic beads were treated with 15 mug/mL of Fasudil at 37degC in 5% CO 2 atmosphere for 72 hours. Fasudil-treated macrophages were suspended in PBS at a concentration of 2 x 10 7 cells/200 muL and intraperitoneally injected into EAE mice on days 3 and 11 postimmunization. PBS-treated macrophages were used as a control. The mice were randomly divided into two groups: the Fasudil-macrophage group (Fasudil-Mphi) (n \u003d12) and the PBS-macrophage group (PBS-Mphi) (n \u003d 12). On day 28 p.i., splenic MNCs were prepared and stained with anti-CD4 (for CD4 + T cells), IFN-gamma (for Th1), IL-17 (for Th17), and IL-10 (for Th2) antibodies, and T cell subsets were analyzed by flow cytometry. Injection of Fasudil-modified macrophages decreased the percentage of CD4 + IL-17 + T cells and increased the percentage of CD4 + IL-10 + T cells. Quantitative results are shown for five mice from each group. The results are expressed as the percentage of double positive cells in the four-quadrant diagram. Data are presented as the mean +- SEM. ** P \u003c 0.01, *** P \u003c 0.001 (Student\u0027s t -test). EAE: Experimental autoimmune encephalomyelits; IFN-gamma: interferon-gamma; IL-10:interleukin-10; IL-17:interleukin-17; MNCs: mononuclear cells; Mphi: macrophage; PBS: phosphate buffer saline.','shortDescription':'Fasudil-modified macrophages affect T cell polarization. A mouse model of chronic EAE was induced by subcutaneous injection of myelin oligodendrocyte glycoprotein peptde 35-55. Macrophages from EAE mice isolated with magnetic beads were treated with 15 mug/mL of Fasudil at 37degC in 5% CO 2 atmosphere for 72 hours. Fasudil-treated macrophages were suspended in PBS at a concentration of 2 x 10 7 cells/200 mu... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Mar 1, 2024, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Neural regeneration research','journalText':'Neural regeneration research 2024 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29059_NRR-19-671-g004.jpg','benchSciPubmedId':'37721300'},{'sku':'11-0041-82','imageId':'1111102','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29056_gr6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29056_gr6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29056_gr6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29056_gr6.jpg?time\u003d20240507','sortOrder':'6','description':'IgM contained in B cell-derived EV can bind antigen CH12 cells were cultured in media alone for two days, after which the conditioned media was subjected to differential ultracentrifugation (DUC) to isolate EV. The EV samples (2kG, 11kG, and 110kG) were resuspended in an equivalent volume of buffer for subsequent analysis by immunoblot and ELISA. (A) An equivalent proportion of each sample was resolved by SDS/PAGE under unreduced conditions, and immunoblotted for IgM and CD81. CH12 cell lysate (lane 1; 7.5 mug) and 110kG supernatant (lane 5), were run as controls. (B) The amount of IgM in each EV sample under buffer +0.25% TX100 conditions was determined by anti-mouse IgM ELISA. For (A) and (B), data are representative of two independent experiments. (C) CH12 cells were incubated with PtC liposomes for 30 min on ice at 1:2000 stock and at sequential 1:2 dilutions thereof, after which FITC fluorescence was determined by flow cytometry and GMI determined. The extreme left data point is the GMI FITC for CH12 cells incubated in buffer only. The turquoise arrowhead indicates the reagent concentration (1:5000 stock) utilized for subsequent experiments. (D) WEHI 231 and CH12 cells were stained with IgM APC and PtC liposome FITC reagent for flow cytometry analysis. Dot plots indicate FMO PtC liposome (first row), FMO IgM APC (second row), and complete stain (third row) fluorescence profiles of single, viable WEHI-231 (left column) and CH12 (right column) cells. (E) EV samples (11kG a','shortDescription':'IgM contained in B cell-derived EV can bind antigen CH12 cells were cultured in media alone for two days, after which the conditioned media was subjected to differential ultracentrifugation (DUC) to isolate EV. The EV samples (2kG, 11kG, and 110kG) were resuspended in an equivalent volume of buffer for subsequent analysis by immunoblot and ELISA. (A) An equivalent proportion of each sample was resolved by S... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 15, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'iScience','journalText':'iScience 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29056_gr6.jpg','benchSciPubmedId':'37636058'},{'sku':'11-0041-82','imageId':'1139012','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29046_urn-x-wiley-20457634-media-cam46242-cam46242-fig-0005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29046_urn-x-wiley-20457634-media-cam46242-cam46242-fig-0005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29046_urn-x-wiley-20457634-media-cam46242-cam46242-fig-0005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29046_urn-x-wiley-20457634-media-cam46242-cam46242-fig-0005.jpg?time\u003d20240507','sortOrder':'7','description':'5 FIGURE Inhibition of YAP could affect TME and tumor proliferation through the STAT3/VEGF/VEGFR-2 axis. (A) The detection of volume and weight of tumors of mice. (B) The tumor morphological changes of mice were observed by HE staining. (C) YAP expression of tumor tissues was tested by RT-qPCR. (D) CD3 + CD4 + , CD3 + CD8 + , and treg cells in tumor tissues were examined by flow cytometry. (E) The ratio of M1 and M2 macrophages in tumor tissues was tested by flow cytometry. (F) The iNOS, IL-12, IL-10, TGF-beta, Arg-1, and CCL-22 expressions were tested by ELISA. (G) IF staining was selected to examine the YAP, STAT3, and p-STAT3 expression levels in tumor tissues. The red signal represented positive staining for YAP, p-STAT3, and STAT3, while the blue signal indicated nuclear staining. (H) The levels of YAP, STAT3, p-STAT3, VEGF, VEGFR-2, and PD-L1 in tumor tissues were examined by WB. All data were presented as mean +- SD ( n \u003d 3) from three independent experiments, each performed in triplicate. *** p \u003c 0.001, ** p \u003c 0.01, * p \u003c 0.05 vs the model group. One-way ANOVA (A, left and B-H). Two-way ANOVA (A, right).','shortDescription':'5 FIGURE Inhibition of YAP could affect TME and tumor proliferation through the STAT3/VEGF/VEGFR-2 axis. (A) The detection of volume and weight of tumors of mice. (B) The tumor morphological changes of mice were observed by HE staining. (C) YAP expression of tumor tissues was tested by RT-qPCR. (D) CD3 + CD4 + , CD3 + CD8 + , and treg cells in tumor tissues were examined by flow cytometry. (E) The ratio of ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancer medicine','journalText':'Cancer medicine 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29046_urn-x-wiley-20457634-media-cam46242-cam46242-fig-0005.jpg','benchSciPubmedId':'37329188'},{'sku':'11-0041-82','imageId':'1131275','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29051_41598_2023_35328_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29051_41598_2023_35328_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29051_41598_2023_35328_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29051_41598_2023_35328_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'8','description':'Increased T cell-mediated immune responses by rAd5-Gn priming and Gn protein boosting. Six-week-old C57BL/6 mice ( n \u003d 5/group) are immunized intramuscularly with 1 x 10 8 infectious units of rAd5-Gn or alum and RNA-adjuvanted Gn protein at 0 and 2 weeks. Mice are sacrificed one week after boosting. ( a , d , g) , and ( j ) Representative flow cytometry plots showing ( a ) follicular helper T cells, ( d ) effector T cells, central memory t cells, ( g ) interferon gamma cytokine-producing T cells, ( j ) activated T cells. Frequencies of ( b ) CXCR5, ( c ) PD-1 expression in CD4 T cell, and ICOS expression in CD4 PD-1 populations from immunized mice spleen. Frequencies of ( e ) effector memory T cells and ( f ) central memory T cells in CD4 T cells were analyzed using flow cytometry. IFN-gamma-producing ( h ) CD4 and ( i ) CD8 T cells in the spleen were analyzed using flow cytometry. ( k ) CD69 and ( l ) CD25 expression in CD4 T cells in the spleen was analyzed using flow cytometry. Data are presented as mean values + SD. P values are calculated using one-way ANOVA with Bonferroni multiple comparison test.','shortDescription':'Increased T cell-mediated immune responses by rAd5-Gn priming and Gn protein boosting. Six-week-old C57BL/6 mice ( n \u003d 5/group) are immunized intramuscularly with 1 x 10 8 infectious units of rAd5-Gn or alum and RNA-adjuvanted Gn protein at 0 and 2 weeks. Mice are sacrificed one week after boosting. ( a , d , g) , and ( j ) Representative flow cytometry plots showing ( a ) follicular helper T cells, ( d ) e... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'May 20, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Scientific reports','journalText':'Scientific reports 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29051_41598_2023_35328_Fig3_HTML.jpg','benchSciPubmedId':'37210393'},{'sku':'11-0041-82','imageId':'1018809','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24723_JIR2022-9543083.004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24723_JIR2022-9543083.004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24723_JIR2022-9543083.004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24723_JIR2022-9543083.004.jpg?time\u003d20240507','sortOrder':'9','description':'Figure 4 IL-33 deficiency inhibited Th17 cells in murine ARDS. (a) The percentage of CD4+ IL-17+CD4+ T cells in the lung was detected by flow cytometry. (b) The mRNA expression of ROR gamma t in the lung was measured by real-time PCR. (c) The protein expression of ROR gamma t in lung tissue was measured by Western blotting. (d) The concentrations of IL-17 and IL-22 in BALF were detected by ELISA. The data are expressed as the means +- SDs. Significant differences are shown by * P \u003c 0.05, ** P \u003c 0.01, and *** P \u003c 0.001 by one-way ANOVA followed by Bonferroni\u0026apos;s post hoc test comparing the WT control, LPS, LPS+rmIL-33, and LPS+IL-33 -/- groups. N \u003d 3-5 for each group, and three independent repeated experiments were carried out.','shortDescription':'Figure 4 IL-33 deficiency inhibited Th17 cells in murine ARDS. (a) The percentage of CD4+ IL-17+CD4+ T cells in the lung was detected by flow cytometry. (b) The mRNA expression of ROR gamma t in the lung was measured by real-time PCR. (c) The protein expression of ROR gamma t in lung tissue was measured by Western blotting. (d) The concentrations of IL-17 and IL-22 in BALF were detected by ELISA. The data a... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Dec 27, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of immunology research','journalText':'Journal of immunology research 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24723_JIR2022-9543083.004.jpg','benchSciPubmedId':'36570798'},{'sku':'11-0041-82','imageId':'1018705','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24720_AD-13-6-1919-g6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24720_AD-13-6-1919-g6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24720_AD-13-6-1919-g6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24720_AD-13-6-1919-g6.jpg?time\u003d20240507','sortOrder':'10','description':'Figure 6. CD4 + CTLs mediated allograft rejection of MSCs with MHC-II upregulation. (A and B) after co-culture with untreated MSCs, LICM-treated MSCs and LICM-treated MHC-II -/- MSCs respectively, allogeneic splenocytes were labeled with fluorochrome-conjugated anti-CD45, CD4, Fas-L, Perforin mAbs, then proliferation of CD4 + CTLs (ratio of CD4 + Fas-L + T cell and CD4 + Perforin + T cell in total CD4 + T cells) was analyzed by flow cytometry (n \u003d 3). The results are representative of three independent experiments as mean +- SD. ** p \u003c 0.01. (C and D) untreated MSCs, LICM-treated MSCs and LICM-treated MHC-II -/- MSCs were mixed with Matrigel respectively and injected subcutaneously in allogeneic mice; Matrigel was retrieved 7 days after injection, infiltrated cells were isolated and labeled with anti-CD4, Fas-L, Perforin mAbs, cell numbers of infiltrated CD4 + CTLs (CD4 + Fas-L + T cell and CD4 + Perforin + T cell) were analyzed by flow cytometry (n \u003d 5). The results are representative of at least three independent experiments as mean +- SD. * p \u003c 0.05, ** p \u003c 0.01. (E) MSCs survival in Matrigel was determined after injection, cells in retrieved Matrigel were isolated and labeled with anti-MHC-I mAb (specific to H-2 b haplotype), cell numbers of survived MSCs were analyzed by flow cytometry (n \u003d 5). The results are representative of at least three independent experiments as mean +- SD. ** p \u003c 0.01, *** p \u003c 0.001. (F) MSCs and MHC-II -/- MSCs were treated with LICM, mixed with','shortDescription':'Figure 6. CD4 + CTLs mediated allograft rejection of MSCs with MHC-II upregulation. (A and B) after co-culture with untreated MSCs, LICM-treated MSCs and LICM-treated MHC-II -/- MSCs respectively, allogeneic splenocytes were labeled with fluorochrome-conjugated anti-CD45, CD4, Fas-L, Perforin mAbs, then proliferation of CD4 + CTLs (ratio of CD4 + Fas-L + T cell and CD4 + Perforin + T cell in total CD4 + T c... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging and disease','journalText':'Aging and disease 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24720_AD-13-6-1919-g6.jpg','benchSciPubmedId':'36465184'},{'sku':'11-0041-82','imageId':'1023073','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24722_41419_2022_5461_Fig6_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24722_41419_2022_5461_Fig6_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24722_41419_2022_5461_Fig6_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24722_41419_2022_5461_Fig6_HTML.jpg?time\u003d20240507','sortOrder':'11','description':'Fig. 6 CB-5083 treatment of LCMV-infected mice after the priming phase strongly impairs health status. C57BL/6 mice were infected with LCMV and treated on d6 post-infection with 50 mg/kg CB-5083 or vehicle. Mice were analyzed 6 h post-CB-5083 treatment. A The movement of the mice was tracked and the individual numbers of steps in 1 min were counted. Values represent mean +- SD. Pooled data ( n \u003d 12) derived from two separate experiments were analyzed by unpaired t test. B IL-1beta, IL-6, TNF-alpha, and IFN-gamma concentrations were determined in the serum ( n \u003d 5-12). Values represent mean +- SD. For each analysis, a Kruskal-Wallis test followed by a Dunn\u0026apos;s test was performed. C , D The blood ( C ) ( n \u003d 27-32) and spleen ( D ) ( n \u003d 16-17) were collected and stained for CD4, CD8, CD11b, CD19, F4/80 and NK1.1 and analyzed by flow cytometry. The data was pooled from three different experiments and analyzed by unpaired t test. Values represent mean +- SD. E Splenocytes were lysed and analyzed via immunoblot for poly-ubiquitin accumulation, BiP, and p-eIF2alpha. On the gamma -axis, the mean signal normalized to gamma-tubulin +- SD from mice ( n \u003d 6) derived from two independent experiments analyzed by an unpaired t test is shown. All values represent mean +- SD. * p \u003c 0.05, ** p \u003c 0.01, *** p \u003c 0.001, and **** p \u003c 0.0001.','shortDescription':'Fig. 6 CB-5083 treatment of LCMV-infected mice after the priming phase strongly impairs health status. C57BL/6 mice were infected with LCMV and treated on d6 post-infection with 50 mg/kg CB-5083 or vehicle. Mice were analyzed 6 h post-CB-5083 treatment. A The movement of the mice was tracked and the individual numbers of steps in 1 min were counted. Values represent mean +- SD. Pooled data ( n \u003d 12) derived... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24722_41419_2022_5461_Fig6_HTML.jpg','benchSciPubmedId':'36456548'},{'sku':'11-0041-82','imageId':'1018768','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24722_41419_2022_5461_Fig4_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24722_41419_2022_5461_Fig4_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24722_41419_2022_5461_Fig4_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24722_41419_2022_5461_Fig4_HTML.jpg?time\u003d20240507','sortOrder':'12','description':'Analysis of immune cells in the spleen of LCMV-infected CB-5083-treated mice. C57BL/6 mice were infected with LCMV (d0), or left uninfected ( A , B ), and treated with 50 mg/kg CB-5083 or vehicle on d0 and d2 post-infection. Spleens were collected on d2 ( A ), d4 ( B ), d6 ( C ), and d8 ( D ). Splenocytes were stained for CD8, CD4, CD11b, CD19, F4/80, and NK1.1 and analyzed by flow cytometry. On the gamma -axis, the absolute cell number of each population is shown. Values represent mean +- SD ( n \u003d 5-12 per group). A and B were analyzed by individual ordinary one-way ANOVA or Kruskal-Wallis test with multiple corrections performed by Tukey or Dunn\u0026apos;s test, respectively. C and D were analyzed by unpaired t test or Mann-Whitney test. For each day analyzed, the data were pooled from two independent experiments. All values represent mean +- SD. * p \u003c 0.05, ** p \u003c 0.01, *** p \u003c 0.001, and **** p \u003c 0.0001.','shortDescription':'Analysis of immune cells in the spleen of LCMV-infected CB-5083-treated mice. C57BL/6 mice were infected with LCMV (d0), or left uninfected ( A , B ), and treated with 50 mg/kg CB-5083 or vehicle on d0 and d2 post-infection. Spleens were collected on d2 ( A ), d4 ( B ), d6 ( C ), and d8 ( D ). Splenocytes were stained for CD8, CD4, CD11b, CD19, F4/80, and NK1.1 and analyzed by flow cytometry. On the gamma -... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24722_41419_2022_5461_Fig4_HTML.jpg','benchSciPubmedId':'36456548'},{'sku':'11-0041-82','imageId':'1018747','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24722_41419_2022_5461_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24722_41419_2022_5461_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24722_41419_2022_5461_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24722_41419_2022_5461_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'13','description':'Analysis of immune cells in the blood of LCMV-infected CB-5083-treated mice. C57BL/6 mice were infected with LCMV (d0), or left uninfected ( A , B ), and treated with 50 mg/kg CB-5083 or vehicle on d0 and d2 post-infection. Blood samples were collected on d2 ( A ), d4 ( B ), d6 ( C ), and d8 ( D ). Blood cells were stained for CD8, CD4, CD11b, CD19, F4/80, and NK1.1 and analyzed by flow cytometry. On the gamma -axis, the absolute cell number/ul of blood of each population is shown. Values represent mean +- SD ( n \u003d 5-11 per group). A and B were analyzed by individual ordinary one-way ANOVA or Kruskal-Wallis test with multiple corrections performed by Tukey or Dunn\u0026apos;s test, respectively. C and D were analyzed by unpaired t test or Mann-Whitney test. Data was pooled from two independent experiments. All values represent mean +- SD. * p \u003c 0.05, ** p \u003c 0.01, *** p \u003c 0.001, and **** p \u003c 0.0001.','shortDescription':'Analysis of immune cells in the blood of LCMV-infected CB-5083-treated mice. C57BL/6 mice were infected with LCMV (d0), or left uninfected ( A , B ), and treated with 50 mg/kg CB-5083 or vehicle on d0 and d2 post-infection. Blood samples were collected on d2 ( A ), d4 ( B ), d6 ( C ), and d8 ( D ). Blood cells were stained for CD8, CD4, CD11b, CD19, F4/80, and NK1.1 and analyzed by flow cytometry. On the ga... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24722_41419_2022_5461_Fig3_HTML.jpg','benchSciPubmedId':'36456548'},{'sku':'11-0041-82','imageId':'1018726','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24721_gr4_lrg.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24721_gr4_lrg.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24721_gr4_lrg.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24721_gr4_lrg.jpg?time\u003d20240507','sortOrder':'14','description':'Fig. 4 SARS-CoV-2-specific T cell immune responses and memory-biased immunity in pSpike/PP-sNP vaccinated mice. Enzyme-linked immunospot (ELISpot) analyses of a ) IFN-gamma and b ) IL-4 spot-forming cells in pulmonary lymphocyte after re-stimulation with peptide pools of 14-mer overlapping peptides spanning the SARS-CoV-2 receptor binding domain (RBD) region. c ) CD4 + T cells and d ) CD8 + T cells in the lung were assayed for IFN-gamma + expression by flow cytometry after re-stimulation with the SARS-CoV-2 RBD peptide pool. e ) CD4 + T cells in the lung were analyzed for IL-4 + expression via flow cytometry in the same way as describe above. f ) Percentage of CD4 + effector memory T cells (T EM ) co-expressing CD44 hi and CD62L lo and central memory T cells (T CM ) co-expressing CD44 hi and CD62L hi in the lung of mice 35 days after priming. g ) Percentage of CD8 + T EM and T CM in lung of mice 35 days after priming. h ) Percentage of CD4 + T RM and i ) CD8 + T RM in lung of mice 35 days after initial vaccination. Data in a-i represent mean +- SEM (n \u003d 5 biologically independent samples). One-way ANOVA with Dunnett\u0026apos;s post-hoc test was used to determine significance (** P \u003c 0.01, *** P \u003c 0.001, **** P \u003c 0.0001). Fig. 4','shortDescription':'Fig. 4 SARS-CoV-2-specific T cell immune responses and memory-biased immunity in pSpike/PP-sNP vaccinated mice. Enzyme-linked immunospot (ELISpot) analyses of a ) IFN-gamma and b ) IL-4 spot-forming cells in pulmonary lymphocyte after re-stimulation with peptide pools of 14-mer overlapping peptides spanning the SARS-CoV-2 receptor binding domain (RBD) region. c ) CD4 + T cells and d ) CD8 + T cells in the l... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2023, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Biomaterials','journalText':'Biomaterials 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24721_gr4_lrg.jpg','benchSciPubmedId':'36436305'},{'sku':'11-0041-82','imageId':'1018684','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24719_DM2022-1542112.008.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24719_DM2022-1542112.008.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24719_DM2022-1542112.008.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24719_DM2022-1542112.008.jpg?time\u003d20240507','sortOrder':'15','description':'Characterization of isolated CD4+ T cells stimulated with IFN- gamma . CD4+ T cells were extracted from the spleen of C57BL/6 mice and stimulated with 100 ng/mL IFN- gamma for 20, 60, or 120 min. (a) Flow cytometry validation of T cell differentiation into Th9 subset with or without IFN- gamma stimulation. Cells expressing IL-9 were identified as Th9 cells. (b) qRT-PCR analysis of expression of IL-9 mRNA in unstimulated and IFN- gamma -stimulated T cells. (c) ELISA of secreted IL-9 in unstimulated and IFN- gamma -stimulated T cells. (d) qRT-PCR of expression of T-bet mRNA in unstimulated and IFN- gamma -stimulated (20, 60, or 120 min) T cells. (e) Western blot analysis and quantification of the phosphorylation of STAT1 and STAT3 (relative to total protein content) in unstimulated and IFN- gamma -stimulated (20, 60, or 120 min) T cells. Results are presented as mean +- SD ( n \u003d 3), * p \u003c 0.05. IFN: interferon; IL: interleukin; STAT: signal transducer and activator of transcription.','shortDescription':'Characterization of isolated CD4+ T cells stimulated with IFN- gamma . CD4+ T cells were extracted from the spleen of C57BL/6 mice and stimulated with 100 ng/mL IFN- gamma for 20, 60, or 120 min. (a) Flow cytometry validation of T cell differentiation into Th9 subset with or without IFN- gamma stimulation. Cells expressing IL-9 were identified as Th9 cells. (b) qRT-PCR analysis of expression of IL-9 mRNA in... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Oct 31, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Disease markers','journalText':'Disease markers 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24719_DM2022-1542112.008.jpg','benchSciPubmedId':'36304255'},{'sku':'11-0041-82','imageId':'988125','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24551_fnagi-14-842380-g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24551_fnagi-14-842380-g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24551_fnagi-14-842380-g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24551_fnagi-14-842380-g006.jpg?time\u003d20240507','sortOrder':'16','description':'FIGURE 6 The effect of rotenone on subpopulations of Peyer\u0027s patches lymphocytes in halpha-syn +/- mice. Flow cytometry was used to detect the changes in lymphocyte subsets, namely, CD4 + , CD8 + , and CD4 + CD25 + lymphocytes, respectively, in Peyer\u0027s patches in mice of different ages. (A) Changes of lymphocyte subsets in Peyer\u0027s patches of 6-month-old halpha-syn +/- mice by flow cytometry, n \u003d 6. (B) Statistics of the number of cells in Peyer\u0027s patches of 6-month-old halpha-syn +/- mice. (C) Changes of lymphocyte subsets in Peyer\u0027s patches of 12-month-old halpha-syn +/- mice by flow cytometry, n \u003d 6. (D) Statistics of the number of cells in Peyer\u0027s patches of 12-month-old halpha-syn +/- mice.','shortDescription':'FIGURE 6 The effect of rotenone on subpopulations of Peyer\u0027s patches lymphocytes in halpha-syn +/- mice. Flow cytometry was used to detect the changes in lymphocyte subsets, namely, CD4 + , CD8 + , and CD4 + CD25 + lymphocytes, respectively, in Peyer\u0027s patches in mice of different ages. (A) Changes of lymphocyte subsets in Peyer\u0027s patches of 6-month-old halpha-syn +/- mice by flow cytometry, n \u003d 6. (B) Stat... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Aug 26, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in aging neuroscience','journalText':'Frontiers in aging neuroscience 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24551_fnagi-14-842380-g006.jpg','benchSciPubmedId':'36004003'},{'sku':'11-0041-82','imageId':'952178','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20554_ijms-23-04482-g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20554_ijms-23-04482-g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20554_ijms-23-04482-g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20554_ijms-23-04482-g006.jpg?time\u003d20240507','sortOrder':'17','description':'Effect of Compound A on the spleen sizes and CD4 + IL-17A + T cell population in FFA4 WT and KO mice. ( A ) The spleens were photographed to record morphological changes. ( B ) Representative flow cytometry dot plots of the FACS analysis of CD4 + IL-17A + T cells. ( C , E ) The measured weights of spleens. ( D , F ) Percentage of CD4 + IL-17A + T cells in the spleens. Data was tested for Gaussian distribution using the KS normality test. The results are presented as the mean +- SEM (n \u003d 5). *** p \u003c 0.001, ** p \u003c 0.01, * p \u003c 0.05 vs. the vehicle-treated group, ### p \u003c 0.001, ## p \u003c 0.001 vs. the imiquimod-treated group.','shortDescription':'Effect of Compound A on the spleen sizes and CD4 + IL-17A + T cell population in FFA4 WT and KO mice. ( A ) The spleens were photographed to record morphological changes. ( B ) Representative flow cytometry dot plots of the FACS analysis of CD4 + IL-17A + T cells. ( C , E ) The measured weights of spleens. ( D , F ) Percentage of CD4 + IL-17A + T cells in the spleens. Data was tested for Gaussian distributi... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 19, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20554_ijms-23-04482-g006.jpg','benchSciPubmedId':'35562873'},{'sku':'11-0041-82','imageId':'952156','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20554_ijms-23-04482-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20554_ijms-23-04482-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20554_ijms-23-04482-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20554_ijms-23-04482-g004.jpg?time\u003d20240507','sortOrder':'18','description':'Effect of Compound A on the lymph node sizes and CD4 + IL-17A + T cell population in FFA4 WT and KO mice. ( A ) The draining lymph nodes were photographed to record morphological changes. ( B ) Representative flow cytometry dot plots of the FACS analysis of CD4 + IL-17A + T cells. ( C , E ) The measured weights of lymph nodes. ( D , F ) Percentage of CD4 + IL-17A + T cells in the lymph nodes. Data were tested for Gaussian distribution using the KS normality test. The results are presented as the mean +- SEM (n \u003d 5). *** p \u003c 0.001 vs. the vehicle-treated group, ### p \u003c 0.001, # p \u003c 0.05 vs. the imiquimod-treated group.','shortDescription':'Effect of Compound A on the lymph node sizes and CD4 + IL-17A + T cell population in FFA4 WT and KO mice. ( A ) The draining lymph nodes were photographed to record morphological changes. ( B ) Representative flow cytometry dot plots of the FACS analysis of CD4 + IL-17A + T cells. ( C , E ) The measured weights of lymph nodes. ( D , F ) Percentage of CD4 + IL-17A + T cells in the lymph nodes. Data were test... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 19, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20554_ijms-23-04482-g004.jpg','benchSciPubmedId':'35562873'},{'sku':'11-0041-82','imageId':'952135','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20553_ppat.1010407.g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20553_ppat.1010407.g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20553_ppat.1010407.g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20553_ppat.1010407.g005.jpg?time\u003d20240507','sortOrder':'19','description':'10.1371/journal.ppat.1010407.g005 Fig 5 Chitinase facilitates in vivo invasion, survival, and pathogenesis of Salmonella Typhimurium. (A) Survival of the mice infected with a lethal dose of STM WT and STM Delta chiA (PBS \u003d Phosphate Buffered Saline). Data are presented from one independent experiment, representative of 3 independent experiments (N \u003d 3). (B) Bacterial shedding in the feces of STM WT and STM Delta chiA infected animals. Data are presented as mean +- SD of 3 independent experiment; each dot represents an individual animal (N \u003d 3, n \u003d 10). (C) In vivo invasion in PP by STM WT and STM Delta chiA . (N \u003d 3). Bacterial burden in (D) liver, (E) spleen, (F) MLN and (G) PP of the infected mice after the indicated time with a sub-lethal dose of STM WT and STM Delta chiA . (N \u003d 3). Unpaired Student\u0027s t test was used to analyze the data for C-G . (H) Body weight of the infected mice 5 dpi with a sub-lethal dose of STM WT and STM Delta chiA . (N \u003d 3). (PBS- Phosphate Buffered Saline). (I) Flow cytometry analysis of CD4 + and CD25 + T cells from total splenocytes isolated from STM WT and STM Delta chiA infected mice 20 dpi (US-PBS- Unstained splenocytes from PBS treated mouse). Data are presented from one independent experiment, representative of 3 independent experiments (N \u003d 3). Pro-inflammatory cytokines (J) IL-2 and (K) IFN-gamma level in serum from STM WT and STM Delta chiA infected mice after the indicated time. (N \u003d 3); One-way ANOVA was used to analyze the data. (L)','shortDescription':'10.1371/journal.ppat.1010407.g005 Fig 5 Chitinase facilitates in vivo invasion, survival, and pathogenesis of Salmonella Typhimurium. (A) Survival of the mice infected with a lethal dose of STM WT and STM Delta chiA (PBS \u003d Phosphate Buffered Saline). Data are presented from one independent experiment, representative of 3 independent experiments (N \u003d 3). (B) Bacterial shedding in the feces of STM WT and STM ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PLoS pathogens','journalText':'PLoS pathogens 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20553_ppat.1010407.g005.jpg','benchSciPubmedId':'35482710'},{'sku':'11-0041-82','imageId':'924001','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19032_fimmu-12-786680-g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19032_fimmu-12-786680-g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19032_fimmu-12-786680-g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19032_fimmu-12-786680-g006.jpg?time\u003d20240507','sortOrder':'20','description':'Figure 6 Depletion of CD8 + T-lymphocytes lowers reparative MoMFs and impairs the resolution of acute liver injury. Mice were treated with an anti-CD8 monoclonal antibody (mAb) 72 hours before and immediately after CCl 4 administration and the evolution of hepatic injury was evaluated 48 hours after CCl 4 poisoning. The distribution of liver and circulating CD4 + and CD8 + T cells and that of hepatic CD11b + /F4-80 + MoMFs was monitored by flow cytometry in mice receiving CCl 4 (A) . The lowering of CD11b + /F4-80 + MoMFs induced by CD8 T-cell ablation involved CD206, TREM-2 and MerTK-expressing cells (B) . The effects of CD8 + T-depletion of the recovery from acute liver injury was evaluated by measuring alanine aminotransferase (ALT) release and histological analysis of liver sections stained with hematoxylin/eosin (magnification 10X) (C) .','shortDescription':'Figure 6 Depletion of CD8 + T-lymphocytes lowers reparative MoMFs and impairs the resolution of acute liver injury. Mice were treated with an anti-CD8 monoclonal antibody (mAb) 72 hours before and immediately after CCl 4 administration and the evolution of hepatic injury was evaluated 48 hours after CCl 4 poisoning. The distribution of liver and circulating CD4 + and CD8 + T cells and that of hepatic CD11b ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 14, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19032_fimmu-12-786680-g006.jpg','benchSciPubmedId':'34925367'},{'sku':'11-0041-82','imageId':'923980','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19031_vaccines-09-01247-g008.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19031_vaccines-09-01247-g008.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19031_vaccines-09-01247-g008.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19031_vaccines-09-01247-g008.jpg?time\u003d20240507','sortOrder':'21','description':'Figure 8 Flow cytometry analysis of T cells in the tumors treated with SFV/IFNg, SFV/Luc, or PBS in orthotopic 4T1 mouse breast cancer model (mice were treated as presented in Figure 6 d). Resected tumors were homogenized to obtain a single cell suspension, which was used for immunostaining with antibodies against surface markers (CD3, CD4, CD8, CD25) and intracellular markers (FoxP3) in one mixture. ( a ) Percentages of cell populations. Th cells were identified as CD3 + /CD4 + ; CTL cells as CD3 + /CD8 + , and T-regs as CD4 + /CD25 + /FoxP3 + populations. ( b ) Representative pictures of forward and side (SSC-A/FSC-A) scattering of the cell populations. Arrows indicate the increased population of lymphocytes in the SFV/IFNg group. Bars represent the means +- SD ( n \u003d 5); * p \u003c 0.05; ** p \u003c 0.01; ns--nonsignificant.','shortDescription':'Figure 8 Flow cytometry analysis of T cells in the tumors treated with SFV/IFNg, SFV/Luc, or PBS in orthotopic 4T1 mouse breast cancer model (mice were treated as presented in Figure 6 d). Resected tumors were homogenized to obtain a single cell suspension, which was used for immunostaining with antibodies against surface markers (CD3, CD4, CD8, CD25) and intracellular markers (FoxP3) in one mixture. ( a ) ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Oct 27, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Vaccines','journalText':'Vaccines 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19031_vaccines-09-01247-g008.jpg','benchSciPubmedId':'34835178'},{'sku':'11-0041-82','imageId':'924064','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19044_JAH3-10-e023077-g007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19044_JAH3-10-e023077-g007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19044_JAH3-10-e023077-g007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19044_JAH3-10-e023077-g007.jpg?time\u003d20240507','sortOrder':'22','description':'Figure 4 Depletion of Tregs in vivo abolished neuroprotection conferred by RLIPoC. A , Scheme for ablation of Tregs in DEREG mice (left) and purified Tregs transferring to recipient mice (right). Diphtheria toxin (DT; intraperitoneal, 50 ug/kg body weight) was administered 2 days before the MCAO model and was administered again with a dose of 10 ug/kg body weight every other day until the mouse was euthanized. Purified CD4 + CD25 + Tregs were transferred intravenously to recipient mice within 1 hour after the MCAO model, with a dose of 1 million per mouse through the tail vein. B , The efficacy of Tregs ablation in DEREG mice using DT. Representative flow cytometry plots and the quantitation of percentages of CD25 + Foxp3 + Tregs among CD4 + T cells in the blood and spleen are shown in the histogram. Student t test, * P \u003c0.05 vs PBS. n\u003d3 per group. C , Neuronal apoptosis was assessed by TUNEL staining at 3 days after MCAO. Representative confocal images of coronal sections labeled with TUNEL and NeuN; the quantitation of NeuN and TUNEL double positive cells are shown in the histogram. Scale bar\u003d50 um. Kruskal-Wallis test with Dunn\u0027s post hoc test. n\u003d6 per group. D , Representative magnetic resonance images and quantification of infarct volume at 3 days after MCAO. One-way ANOVA with Bonferroni\u0027s post hoc test. n\u003d6 per group. DEREG indicates depletion of regulatory T cell; MCAO, middle cerebral artery occlusion; NeuN, neuronal nuclei; RLIPoC, remote limb ischemic postcondition','shortDescription':'Figure 4 Depletion of Tregs in vivo abolished neuroprotection conferred by RLIPoC. A , Scheme for ablation of Tregs in DEREG mice (left) and purified Tregs transferring to recipient mice (right). Diphtheria toxin (DT; intraperitoneal, 50 ug/kg body weight) was administered 2 days before the MCAO model and was administered again with a dose of 10 ug/kg body weight every other day until the mouse was euthaniz... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Nov 16, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of the American Heart Association','journalText':'Journal of the American Heart Association 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19044_JAH3-10-e023077-g007.jpg','benchSciPubmedId':'34726065'},{'sku':'11-0041-82','imageId':'924043','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19044_JAH3-10-e023077-g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19044_JAH3-10-e023077-g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19044_JAH3-10-e023077-g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19044_JAH3-10-e023077-g005.jpg?time\u003d20240507','sortOrder':'23','description':'Figure 3 RLIPoC facilitated Tregs increase via modifying metabolic spectrum. A , Images of blood flow (top) and curves of the dynamic concentration changes of metabolites (FAD, Cytaa3-R, and Cytc-R) in the region of the hind limb underwent RLIPoC in vivo, which was monitored using a multispectral optical imaging system. O indicates occlusion of the bilateral femoral arteries; and R, reperfusion of the bilateral femoral arteries. B , Concentrations of NAD + and NADH, and the ratio of NAD + to NADH, in muscle that underwent RLIPoC. Student t test, * P \u003c0.05, ** P \u003c0.01 vs control. n\u003d4 per group. C , Concentrations of NAD + and NADH and the ratio of NAD + to NADH in the blood. Student t test, * P \u003c0.05, ** P \u003c0.01 vs control. n\u003d4 per group. D , Scheme for NADH administration. NADH (intraperitoneal 50 mg/mouse) was administered within 1 hour after the MCAO model, and the mouse was euthanized at 3 days after MCAO and NADH administration. E , Representative flow cytometry plots and quantitation of percentages of CD25 + Foxp3 + Tregs among CD4 + T cells in the blood and spleen after 3 days of MCAO are shown in the histogram. Student t test, * P \u003c0.05, ** P \u003c0.01 vs MCAO. n\u003d5 to 6 per group. F , Representative confocal images of coronal sections labeled Tregs with EGFP, and quantification of EGFP-positive cells are shown in the histogram. Scale bar\u003d50 um. Student t test, * P \u003c0.05 vs MCAO. n\u003d6 per group. Cytaa3-R indicates cytochrome aa3 in a reduced state; Cytc-R, cytochrome c in a','shortDescription':'Figure 3 RLIPoC facilitated Tregs increase via modifying metabolic spectrum. A , Images of blood flow (top) and curves of the dynamic concentration changes of metabolites (FAD, Cytaa3-R, and Cytc-R) in the region of the hind limb underwent RLIPoC in vivo, which was monitored using a multispectral optical imaging system. O indicates occlusion of the bilateral femoral arteries; and R, reperfusion of the bilat... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Nov 16, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of the American Heart Association','journalText':'Journal of the American Heart Association 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19044_JAH3-10-e023077-g005.jpg','benchSciPubmedId':'34726065'},{'sku':'11-0041-82','imageId':'924022','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19044_JAH3-10-e023077-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19044_JAH3-10-e023077-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19044_JAH3-10-e023077-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19044_JAH3-10-e023077-g004.jpg?time\u003d20240507','sortOrder':'24','description':'Figure 2 RLIPoC increases Tregs abundance in the blood, spleen, and brain. A , Representative flow cytometry plots of CD4 + CD25 + Foxp3 + Tregs in the blood and spleen on day 1, 3, and 7 after MCAO. B , Quantification of percentages of CD25 + Foxp3 + Tregs among CD4 + T cells in the blood and spleen. Student t test, * P \u003c0.05, *** P \u003c0.001 vs MCAO. n\u003d5 to 6 per group. C , Representative flow cytometry plots and quantification of percentages of CD25 + Foxp3 + Tregs among CD4 + T cells in ipsilateral hemispheres on days 1, 3, and 7 after MCAO were shown in the histogram. Student t test, * P \u003c0.05 vs MCAO. n\u003d5 to 6 per group. D , Tregs number at peri-infarct area was evaluated using transgenic mice with EGFP-tagged Foxp3 at different time points after MCAO. Representative confocal images of coronal sections labeled Tregs with EGFP and quantification of EGFP-positive cells are shown in the histogram. Scale bar\u003d50 um. Student t test, * P \u003c0.05 vs MCAO. n\u003d6 per group. EGFP indicates enhanced green fluorescence protein; MCAO, middle cerebral artery occlusion; RLIPoC, remote limb ischemic postconditioning; and Tregs, regulatory T cells.','shortDescription':'Figure 2 RLIPoC increases Tregs abundance in the blood, spleen, and brain. A , Representative flow cytometry plots of CD4 + CD25 + Foxp3 + Tregs in the blood and spleen on day 1, 3, and 7 after MCAO. B , Quantification of percentages of CD25 + Foxp3 + Tregs among CD4 + T cells in the blood and spleen. Student t test, * P \u003c0.05, *** P \u003c0.001 vs MCAO. n\u003d5 to 6 per group. C , Representative flow cytometry plot... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Nov 16, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of the American Heart Association','journalText':'Journal of the American Heart Association 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19044_JAH3-10-e023077-g004.jpg','benchSciPubmedId':'34726065'},{'sku':'11-0041-82','imageId':'923958','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19026_cancers-13-05019-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19026_cancers-13-05019-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19026_cancers-13-05019-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19026_cancers-13-05019-g004.jpg?time\u003d20240507','sortOrder':'25','description':'Figure 4 Proof-of-mechanism study for TAX2 use as an anti-tumor immunomodulatory drug. The effects of TAX2 peptide treatment on the activation of an anti-tumor immune response were investigated in two syngeneic models of epithelial ovarian carcinoma. We inoculated 5 x 10 6 ID8 cells either subcutaneously or intraperitoneally to C57BL/6JRj mice in order to mimic primary tumor growth ( a - h ) and metastatic dissemination (peritoneal carcinosis, i - l ), respectively. TAX2 treatments (30 mg * kg -1 BW) vs. vehicle injections (0.9% NaCl) were performed thrice weekly for 4 and 8 weeks for the s.c. and i.p. ID8 models, respectively ( n \u003d 11 per group for both models). ( a - h ) IHC staining of s.c. ovarian carcinoma allografts for the analysis of the vascular/lymphovascular features, as well as immune-cell-infiltration profile. ( a ) Representative microphotograph for CD31 immunostaining of intra-tumor vascular structures. Histogram displays results of automated quantification for the percent of CD31-positive pixels across the whole tumor section (mean +- SEM, Mann-Whitney U test; n.s., not significant). ( b ) Lymphatic vessel density analysis. Microscopic views are shown, while histogram displays the number of Lyve-1-positive functional lymphatic vessels in 5 high power fields (HPF), as determined by a pathologist who was blinded to the treatment (mean +- SEM, Mann-Whitney U test, * p \u003c 0.05). ( c - f ) Macroscopic views (x20 magnification) of s.c. tumor allograft sections after','shortDescription':'Figure 4 Proof-of-mechanism study for TAX2 use as an anti-tumor immunomodulatory drug. The effects of TAX2 peptide treatment on the activation of an anti-tumor immune response were investigated in two syngeneic models of epithelial ovarian carcinoma. We inoculated 5 x 10 6 ID8 cells either subcutaneously or intraperitoneally to C57BL/6JRj mice in order to mimic primary tumor growth ( a - h ) and metastatic ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)','title':'CD4 Antibody (11-0041-82) in IHC, Flow','appAbv':'Flow','dateTime':'Oct 7, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancers','journalText':'Cancers 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19026_cancers-13-05019-g004.jpg','benchSciPubmedId':'34638503'},{'sku':'11-0041-82','imageId':'923832','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig4_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig4_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14839_41467_2021_25990_Fig4_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14839_41467_2021_25990_Fig4_HTML.jpg?time\u003d20240507','sortOrder':'26','description':'Fig. 4 Evaluation of enhanced ferroptosis induced by HGF-relative exosomal PD-L1 inhibition. a In vitro schedule for ferroptosis-relevant tests. b Relative IFN-gamma release from CD8 + T cells incubated in different conditions. n \u003d 5 biologically independent samples per group. c Relative lipid ROS of B16F10 cells co-cultured with CD8 + T cells after incubating in PBS, HACA-Fe, HACA-GW, and HGF NPs for 48 h. n \u003d 5 biologically independent samples per group. d CLSM observation of expression of SLC7A11 and SLC3A2 in B16F10 cells treated with PBS, HGF or HGF + IFN-gamma for 24 h. Scale bar: 20 mum. Experiments were performed three times independently with similar results. e GPX4 activity in B16F10 cells co-cultured with CD8 + T cells after incubating in PBS, HACA-Fe, HACA-GW, and HGF NPs. n \u003d 5 biologically independent samples per group. f Schematic showing the experiment design for in vivo evaluations ( g - o ). n \u003d 5 biologically independent animals per group. g The intratumoral IFN-gamma level after treatment. G1, PBS; G2, HACA-Fe; G3, HACA-GW; G4, HGF. h IFN-gamma secretion in serum. i and j Flow cytometric quantification of IFN-gamma + T cells after gating on CD3 + CD8 + T cells ( i ) and CD3 + CD4 + T cells ( j ) in TDLN. k Immunofluorescence assay for the expression of SLC7A11 and SLC3A2 in tumor tissues. Scale bar: 50 mum. l - o Cystine ( l ), GSH ( m ), GPX4 activation ( n ), and lipid ROS ( o ) levels in B16F10 tumor tissue after treatment. All data are presented as mea','shortDescription':'Fig. 4 Evaluation of enhanced ferroptosis induced by HGF-relative exosomal PD-L1 inhibition. a In vitro schedule for ferroptosis-relevant tests. b Relative IFN-gamma release from CD8 + T cells incubated in different conditions. n \u003d 5 biologically independent samples per group. c Relative lipid ROS of B16F10 cells co-cultured with CD8 + T cells after incubating in PBS, HACA-Fe, HACA-GW, and HGF NPs for 48 h.... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 30, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14839_41467_2021_25990_Fig4_HTML.jpg','benchSciPubmedId':'34593794'},{'sku':'11-0041-82','imageId':'923811','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14839_41467_2021_25990_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14839_41467_2021_25990_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'27','description':'Fig. 3 HGF NPs inhibited exosomal PD-L1 and triggered robust immunostimulation. a Western blot analysis of exosome marker CD63 and PD-L1 via collecting the exosomes from the cell-free media of B16F10 cells with various treatments. GAPDH served as a loading control. Images were representative of the three experiments. b Scheme of in vivo experimental design for ( c - m ). C57BL/6 mice were subcutaneously inoculated with 1 x 10 6 B16F10 cells. When tumor volumes reached ~ 100 mm 3 , mice were treated with PBS, HACA-Fe, HACA-GW, or HGF on day 0, day 2, and day 4. Tumor and tumor-draining lymph node (TDLN) were collected on day 7 for further analysis. c Western blot analysis of exosome marker CD63 and PD-L1 in tumor tissues after treatment. Images were representative of the three experiments. d-f Flow cytometric plots ( d ) and quantification of CD8 + ( e ) and CD4 + ( f ) T cells, respectively, gated by CD3 + T cells in the TDLN ( n \u003d 5) in groups of PBS (G1), HACA-Fe (G2), HACA-GW (G3), HGF (G4), and HGF + liproxstatin (G5). g-m Flow cytometric analysis of granzyme B + (GzmB + , g - i ), Ki67 + ( j and k ), and Tim3 + ( l and m ) in CD8 + and CD4 + T cells. n \u003d 5 biologically independent animals per group. Data were presented as mean +- SD. Statistically significant differences between groups were identified by one-way ANOVA with Tukey\u0027s post hoc test. * P \u003c 0.05, ** P \u003c 0.01, *** P \u003c 0.001, and **** P \u003c 0.0001.','shortDescription':'Fig. 3 HGF NPs inhibited exosomal PD-L1 and triggered robust immunostimulation. a Western blot analysis of exosome marker CD63 and PD-L1 via collecting the exosomes from the cell-free media of B16F10 cells with various treatments. GAPDH served as a loading control. Images were representative of the three experiments. b Scheme of in vivo experimental design for ( c - m ). C57BL/6 mice were subcutaneously ino... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 30, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14839_41467_2021_25990_Fig3_HTML.jpg','benchSciPubmedId':'34593794'},{'sku':'11-0041-82','imageId':'923853','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14839_41467_2021_25990_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14839_41467_2021_25990_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'28','description':'Fig. 5 HGF induced an effective therapeutic effect against B16F10 tumor. a Schematic illustration of the experiment design to assess the tumor inhibition and the immune responses as triggered by PBS, HACA-Fe, HACA-GW, or HGF NPs on subcutaneous B16F10 tumor model. G1, PBS; G2, HACA-Fe; G3, HACA-GW; G4, HGF. b and c Tumor growth curves during treatment. d Survival rates of different groups over time. e and f Representative flow cytometry plots and quantification of e CD8 + f and CD4 + T cells after gating on CD45 + CD3 + T cells in tumor tissue. g and h Representative flow cytometric analysis of memory T cells (CD3 + CD8 + CD44 + CD62L - , gated on CD3 + CD8 + T cells) in the spleen. Data were presented as mean +- SD. n \u003d 5 biologically independent animals per group. Statistically significant differences between groups were identified by one-way ANOVA with Tukey\u0027s post hoc test. * P \u003c 0.05, ** P \u003c 0.01, *** P \u003c 0.001 and **** P \u003c 0.0001.','shortDescription':'Fig. 5 HGF induced an effective therapeutic effect against B16F10 tumor. a Schematic illustration of the experiment design to assess the tumor inhibition and the immune responses as triggered by PBS, HACA-Fe, HACA-GW, or HGF NPs on subcutaneous B16F10 tumor model. G1, PBS; G2, HACA-Fe; G3, HACA-GW; G4, HGF. b and c Tumor growth curves during treatment. d Survival rates of different groups over time. e and f... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 30, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14839_41467_2021_25990_Fig5_HTML.jpg','benchSciPubmedId':'34593794'},{'sku':'11-0041-82','imageId':'923874','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig6_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig6_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14839_41467_2021_25990_Fig6_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14839_41467_2021_25990_Fig6_HTML.jpg?time\u003d20240507','sortOrder':'29','description':'Fig. 6 In vivo therapeutic impetus of HGF to PD-L1 checkpoint inhibitor therapy. a Schematic illustration of the experiment design to assess the tumor inhibition and the immune responses as triggered by PBS, anti-PD-L1, HGF or HGF + anti-PD-L1 on subcutaneous B16F10 tumor model. G1, PBS; G2, anti-PD-L1; G3, HGF; G4, HGF + anti-PD-L1. b and c Tumor growth curves during treatment. d Survival rates of different groups over time. e - g Flow cytometric plots and quantification of e CD8 + and f CD3 + g T cells, among CD3 + T cells in the TDLN. h - m Flow cytometric quantification of GzmB + cells ( h - i ), Ki67 + cells ( j and k ) and Tim3 + cells ( l and m ) in CD8 + and CD4 + T cells. Data were presented as mean +- SD. n \u003d 5 biologically independent animals per group. Statistically significant differences between groups were identified by one-way ANOVA with Tukey\u0027s post hoc test. * P \u003c 0.05, ** P \u003c 0.01, *** P \u003c 0.001, and **** P \u003c 0.0001.','shortDescription':'Fig. 6 In vivo therapeutic impetus of HGF to PD-L1 checkpoint inhibitor therapy. a Schematic illustration of the experiment design to assess the tumor inhibition and the immune responses as triggered by PBS, anti-PD-L1, HGF or HGF + anti-PD-L1 on subcutaneous B16F10 tumor model. G1, PBS; G2, anti-PD-L1; G3, HGF; G4, HGF + anti-PD-L1. b and c Tumor growth curves during treatment. d Survival rates of differen... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 30, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14839_41467_2021_25990_Fig6_HTML.jpg','benchSciPubmedId':'34593794'},{'sku':'11-0041-82','imageId':'923916','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19043_41368_2021_136_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19043_41368_2021_136_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19043_41368_2021_136_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19043_41368_2021_136_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'30','description':'Fig. 5 P. gingivalis - and comDelta ppad -exacerbated UC is associated with an imbalance in Th17/Tregs. a , b Flow cytometric analysis and bar chart showing that compared with Delta ppad , P. gingivalis and comDelta ppad induced the transformation of CD4 + T cells into proinflammatory Th17 cells and simultaneously inhibited the generation of Tregs ( P \u003c 0.05), but no difference was observed between mice administered Delta ppad and DSS and mice with colitis administered physiological saline ( P \u003e 0.05). c ELISA showing that compared with Delta ppad , P. gingivalis and comDelta ppad administration caused the increased expression of IL-17 and decreased expression of IL-10 in serum ( P \u003c 0.05). The expression levels of the two cytokines were similar in the mice administered Delta ppad and DSS mice and the mice with colitis ( P \u003e 0.05). All indicators were measured with six replicates. The data are presented as the mean +- SD. * P \u003c 0.05, ** P \u003c 0.01, *** P \u003c 0.000 1 by independent 2-tailed Student\u0027s t test and one-way ANOVA combined with Mann-Whitney U test','shortDescription':'Fig. 5 P. gingivalis - and comDelta ppad -exacerbated UC is associated with an imbalance in Th17/Tregs. a , b Flow cytometric analysis and bar chart showing that compared with Delta ppad , P. gingivalis and comDelta ppad induced the transformation of CD4 + T cells into proinflammatory Th17 cells and simultaneously inhibited the generation of Tregs ( P \u003c 0.05), but no difference was observed between mice adm... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 30, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of oral science','journalText':'International journal of oral science 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19043_41368_2021_136_Fig5_HTML.jpg','benchSciPubmedId':'34593756'},{'sku':'11-0041-82','imageId':'923895','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19043_41368_2021_136_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19043_41368_2021_136_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19043_41368_2021_136_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19043_41368_2021_136_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'31','description':'Fig. 2 P. gingivalis -exacerbated UC is associated with an imbalance in Th17/Tregs. a , b Flow cytometric analysis and bar chart showing that compared with the NC group and the DSS group, P. gingivalis significantly induced the transformation of CD4 + T cells into proinflammatory Th17 cells ( P \u003c 0.01) and inhibited the generation of Tregs ( P \u003c 0.05). c ELISA showing that compared with the other two groups, P. gingivalis administration to mice with colitis significantly increased the expression level of IL-17 ( P \u003c 0.01) and decreased expression of IL-10 in serum ( P \u003c 0.05). All the indicators were measured in six replicates. The data are presented as the mean +- SD. * P \u003c 0.05, ** P \u003c 0.01, *** P \u003c 0.000 1 by independent 2-tailed Student\u0027s t test and one-way ANOVA combined with Mann-Whitney U test','shortDescription':'Fig. 2 P. gingivalis -exacerbated UC is associated with an imbalance in Th17/Tregs. a , b Flow cytometric analysis and bar chart showing that compared with the NC group and the DSS group, P. gingivalis significantly induced the transformation of CD4 + T cells into proinflammatory Th17 cells ( P \u003c 0.01) and inhibited the generation of Tregs ( P \u003c 0.05). c ELISA showing that compared with the other two groups... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 30, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of oral science','journalText':'International journal of oral science 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19043_41368_2021_136_Fig2_HTML.jpg','benchSciPubmedId':'34593756'},{'sku':'11-0041-82','imageId':'923937','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14887_gr6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14887_gr6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14887_gr6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14887_gr6.jpg?time\u003d20240507','sortOrder':'32','description':'Figure 6 Assessments of organ damage and mouse metabolites during HLSA or recovery from HLSA. A , upper left panel , MMP-1, IL-1beta, and CRP levels in plasma had no significant change between the control group, HLSA group, and R-HLSA group. Upper right panel , CK-MB as a marker of heart injury in the plasma had no significant change between the control group, HLSA group, and R-HLSA group. Lower left panel , creatinine and BUN as markers of kidney injury in the plasma slightly increased in the HLSA group and returned to normal level after recovery from HLSA. Lower right panel , AST and ALT as markers of liver injury in the plasma showed no change between the control group, HLSA group, and R-HLSA group. Data were presented as mean +- SD (N \u003d 6; ANOVA: ** p \u003c 0.01). B , upper panel , food consumption and water consumption 3 days before and 3 days after a single ATP-induced HLSA depicted no change. Data were presented as mean +- SD (N \u003d 6; ANOVA: p \u003e 0.05). Lower panel , metabolomics analysis of scores plot from PCA analysis based on 1 H NMR data from the plasma, brain, liver, and kidney of the control group, HLSA group, and R-HLSA group. The PCA score showcased clusters correspond to metabolic patterns in different groups, with each point representing one sample. Circles represent 95% confidence interval for each score in each group (see also Figs. S5-S8 ). C , draining lymph nodes of mice that underwent HLSA once a day for 10 consecutive days were analyzed with FACS. CD44 and','shortDescription':'Figure 6 Assessments of organ damage and mouse metabolites during HLSA or recovery from HLSA. A , upper left panel , MMP-1, IL-1beta, and CRP levels in plasma had no significant change between the control group, HLSA group, and R-HLSA group. Upper right panel , CK-MB as a marker of heart injury in the plasma had no significant change between the control group, HLSA group, and R-HLSA group. Lower left panel ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Oct 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of biological chemistry','journalText':'The Journal of biological chemistry 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14887_gr6.jpg','benchSciPubmedId':'34487763'},{'sku':'11-0041-82','imageId':'923773','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14881_thnov11p8570g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14881_thnov11p8570g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14881_thnov11p8570g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14881_thnov11p8570g006.jpg?time\u003d20240507','sortOrder':'33','description':'Figure 6 mEVs restore DSS-disturbed balance between Treg and Th17 cells in the colonic lamina propria (LP). (A) mRNA expression of IL-10 in colon tissue (normalized to GAPDH). (B, C) Protein levels of cytokines IL-10 and IL-17A in colon tissue measured by ELISA. (D-F) Flow cytometry analysis of CD4 + CD25 + FoxP3 + Treg cells (D), IL-10 + FoxP3 + cells (E), and Th17 cells (F) in the colonic LP. (G) Expression of IL-23R protein in the colon. Data were presented as means +- SD. N \u003d 4 to 5 mice per group. * p \u003c 0.05, # p \u003c 0.01.','shortDescription':'Figure 6 mEVs restore DSS-disturbed balance between Treg and Th17 cells in the colonic lamina propria (LP). (A) mRNA expression of IL-10 in colon tissue (normalized to GAPDH). (B, C) Protein levels of cytokines IL-10 and IL-17A in colon tissue measured by ELISA. (D-F) Flow cytometry analysis of CD4 + CD25 + FoxP3 + Treg cells (D), IL-10 + FoxP3 + cells (E), and Th17 cells (F) in the colonic LP. (G) Expressi... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jan 28, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Theranostics','journalText':'Theranostics 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14881_thnov11p8570g006.jpg','benchSciPubmedId':'34373759'},{'sku':'11-0041-82','imageId':'923752','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14880_41419_2021_3874_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14880_41419_2021_3874_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14880_41419_2021_3874_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14880_41419_2021_3874_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'34','description':'Fig. 1 Levels of MDSCs in the heart are positively associated with age. A WGCNA of the coexpressed genes from 135 human whole blood transcriptomes from the GEO database (GSE123698). ME0 was related to age (correlation coefficient \u003d 0.15) but not to sex (correlation coefficient \u003d 0.043). Red indicates a positive correlation, and blue indicates a negative correlation. B Hypergeometric test of the genes in ME0 based on the immunologic gene set from GSE123698. The size of the dot represents the number of genes. A darker color indicates a lower correlation. C The bubble plots show the correlation between the G-MDSC/M-MDSC signature and age in males and females based on GSE123698. D The ratio (left) and signature value (right) of the G-MDSCs and M-MDSCs in 3-month-old and 16-month-old mice determined by scRNA-Seq analysis (GSE145477). E Representative flow cytometric profile showing the quantitative analysis of Cd11b + Gr1 + Ly6G+ cells and Cd11b + Gr1 + Ly6C+ cells in the hearts of young and aging mice; n \u003d 5 per group. F CFSE-labeled CD4 + and CD8 + T cells and G-MDSCs separated from hearts were cocultured at a ratio of 2:1 for 24 h. Representative images and quantitative analysis of the proliferation of CD4 + or CD8 + T cells analyzed by flow cytometry; n \u003d 6 per group. The data are presented as the means +- SDs. Differences were determined by Student\u0027s t test. * P \u003c 0.05.','shortDescription':'Fig. 1 Levels of MDSCs in the heart are positively associated with age. A WGCNA of the coexpressed genes from 135 human whole blood transcriptomes from the GEO database (GSE123698). ME0 was related to age (correlation coefficient \u003d 0.15) but not to sex (correlation coefficient \u003d 0.043). Red indicates a positive correlation, and blue indicates a negative correlation. B Hypergeometric test of the genes in ME0... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jun 8, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14880_41419_2021_3874_Fig1_HTML.jpg','benchSciPubmedId':'34103476'},{'sku':'11-0041-82','imageId':'923689','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14876_fimmu-12-678999-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14876_fimmu-12-678999-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14876_fimmu-12-678999-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14876_fimmu-12-678999-g003.jpg?time\u003d20240507','sortOrder':'35','description':'Figure 3 Expression of IDO1 leads to poor tumor infiltration by CD8+ T cells and increased infiltration of suppressive immune cells in the ovarian tumor microenvironment. (A) Frequency of CD8+ TILs on Days 28 and 57 from WT C57BL/6 (left panel n\u003d6) and IDOKO (right panel n\u003d6) mice challenged i.p. with 1x10e7 IE9mp1-mIDO1 or IE9mp1-EV tumor cells. (B) Immuno-stained IE9mp1-mIDO1 and IE9mp1-EV tumor from WT C57BL/6 mice on Day 48 with anti-IDO1 (green), CD8+ T cell (red), and DAPI (blue). Quantification of CD8+ T cells from 3 field images per tissue slide, (n\u003d11 IE9mp1-EV and n\u003d8 IE9mp1-mIDO1). Total original magnification is 63x. (C) Flow cytometry analysis of tumor ascites for CD4 + CD25 + FoxP3 + T cell frequency in IE9mp1-mIDO1 (n\u003d7) and IE9mp1-EV (n\u003d5) tumor-bearing WT C57BL/6 mice on Day 48. (D) Frequency of Ly6G+in CD11b + cell IE9mp1-EV (n\u003d5) or IE9mp1-mIDO1 (n\u003d5) tumor-bearing WT C57BL/6 mice on Day 28. *p \u003c 0.05, **p \u003c 0.01, using Student\u0027s t test (B-D) . The data represent means +- SEM of three independent experiments.','shortDescription':'Figure 3 Expression of IDO1 leads to poor tumor infiltration by CD8+ T cells and increased infiltration of suppressive immune cells in the ovarian tumor microenvironment. (A) Frequency of CD8+ TILs on Days 28 and 57 from WT C57BL/6 (left panel n\u003d6) and IDOKO (right panel n\u003d6) mice challenged i.p. with 1x10e7 IE9mp1-mIDO1 or IE9mp1-EV tumor cells. (B) Immuno-stained IE9mp1-mIDO1 and IE9mp1-EV tumor from WT C... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Oct 29, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14876_fimmu-12-678999-g003.jpg','benchSciPubmedId':'34025677'},{'sku':'11-0041-82','imageId':'1018663','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24718_pone.0251233.g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24718_pone.0251233.g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24718_pone.0251233.g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24718_pone.0251233.g002.jpg?time\u003d20240507','sortOrder':'36','description':'10.1371/journal.pone.0251233.g002 Fig 2 Rora is expressed in activated T cells in vivo , with mainly spatial variation. (a) Experimental design for single-cell RT-qPCR. (b) Gene expression according to RT-qPCR from CD4+ T cells during N . brasiliensis infection. Gata3 hi cells, which we assume are Th2, are also expressing Rora . The category \'\'\'\'Cytokines\'\'\'\' refers to any of Ifng , Il4 , Il13 , Il5 , Il6 , Il10 or Il17a being expressed. Top row denotes spatial location: Lung, gut (siLIP), mesenteric and mediastinal lymph nodes (n \u003d 4 mice). Every column is one individual cell. (c) Flow cytometric analysis of CD4+ T cells from the spleen and lung of Rora +/teal naive mice (black histogram \u003d Rora teal- cells, green histogram \u003d Rora teal + cells) (n \u003d 23). All error bars are +-sample s.d. (d) Frequency of Rora teal expression across tissues, with siLIP having the highest number (n \u003d 12). (e) Fraction of naive (CD4+CD25-CD44-SELL+) or activated cells expressing Rora teal . RORA is mainly expressed in activated cells in vivo (n \u003d 12) . (f) N . brasiliensis Rora expression over time, overlaid with previously published mouse and human in vitro time course data of Rora , showing no or low expression of Rora in activated in vitro T cells. (g) Experimental design of scRNA-seq experiment, with (h) tSNE clustering of CD4+ T cells extracted from N . brasiliensis infected mice and measured by single-cell RNA-seq (1670 cells after filtering). We primarily identify Naive, Th1, Th2 and Treg','shortDescription':'10.1371/journal.pone.0251233.g002 Fig 2 Rora is expressed in activated T cells in vivo , with mainly spatial variation. (a) Experimental design for single-cell RT-qPCR. (b) Gene expression according to RT-qPCR from CD4+ T cells during N . brasiliensis infection. Gata3 hi cells, which we assume are Th2, are also expressing Rora . The category \'\'\'\'Cytokines\'\'\'\' refers to any of Ifng , Il4 , Il13 , Il5 , Il6 ,... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Nov 12, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24718_pone.0251233.g002.jpg','benchSciPubmedId':'34003838'},{'sku':'11-0041-82','imageId':'923667','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19041_JEM_20201763_FigS5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19041_JEM_20201763_FigS5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19041_JEM_20201763_FigS5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19041_JEM_20201763_FigS5.jpg?time\u003d20240507','sortOrder':'37','description':'Figure S5. Generation of T cell- or myeloid-specific PLCbeta4-deficient mice. (A and B) BMDM, CD4 + , or CD8 + T cells from WT, PLC4beta4 fl/fl , Lyz2-Cre/PLCbeta4 fl/fl , or Lck-Cre/PLCbeta4 fl/fl mice were lysed. PLCbeta4 protein levels in the indicated lysates were determined by Western blotting with indicated Abs. (C) WT or PLCbeta4-deficient mice ( n \u003d 3 per group) were infected with 1 x 10 5 T. gondii . After 5 d, the percentages of CD69 + (left) and CD62L low (right) population on CD4 + T cells in the spleens from parasites infected WT or PLCbeta4-deficient mice were measured by flow cytometry. (D) WT or PLCbeta4-deficient mice ( n \u003d 6 per group) were infected with 1 x 10 5 OVA expressing irradiated T. gondii . 14 d after infection, the percentages and cell numbers of OVA tetramer-positive CD4 + T cells in the spleens from parasite-infected WT or PLCbeta4-deficient mice were measured by flow cytometry. (E) Luciferase activities of serial dilutions of Pru expressing luciferase (10 3 -10 7 ) were plotted. A standard curve of luciferase activity (x axis) and parasite number (y axis) was generated by the data plots. Indicated values are means +- SD of three biological replicates (C). N.S., nonsignificant. Data are cumulative of three independent experiments (D) and representative of two (A, B) or three (E) independent experiments.','shortDescription':'Figure S5. Generation of T cell- or myeloid-specific PLCbeta4-deficient mice. (A and B) BMDM, CD4 + , or CD8 + T cells from WT, PLC4beta4 fl/fl , Lyz2-Cre/PLCbeta4 fl/fl , or Lck-Cre/PLCbeta4 fl/fl mice were lysed. PLCbeta4 protein levels in the indicated lysates were determined by Western blotting with indicated Abs. (C) WT or PLCbeta4-deficient mice ( n \u003d 3 per group) were infected with 1 x 10 5 T. gondii... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jul 5, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of experimental medicine','journalText':'The Journal of experimental medicine 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19041_JEM_20201763_FigS5.jpg','benchSciPubmedId':'33970189'},{'sku':'11-0041-82','imageId':'923646','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19041_JEM_20201763_FigS2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19041_JEM_20201763_FigS2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19041_JEM_20201763_FigS2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19041_JEM_20201763_FigS2.jpg?time\u003d20240507','sortOrder':'38','description':'Figure S2. PLCbeta4-deficient mice show intact T cell development and Th1 differentiation. (A) Percentages and cell numbers of CD4 - /CD8 - , CD4 + /CD8 - , CD4 - /CD8 + , and CD4 + /CD8 + in the thymocytes from WT or PLCbeta4-deficient mice were analyzed by flow cytometry. (B) Percentages and cell numbers of CD4 + and CD8 + T cells in the splenocytes from WT or PLCbeta4-deficient mice were analyzed by flow cytometry. (C) Naive CD4 + T cells from WT or PLCbeta4-deficient mice were cultured under Th1-polarizing conditions for 3 d. Frequencies of IFN-gamma producers were determined by intracellular staining using flow cytometry. Indicated values are means +- SD of three biological replicates (A-C). N.S., nonsignificant.','shortDescription':'Figure S2. PLCbeta4-deficient mice show intact T cell development and Th1 differentiation. (A) Percentages and cell numbers of CD4 - /CD8 - , CD4 + /CD8 - , CD4 - /CD8 + , and CD4 + /CD8 + in the thymocytes from WT or PLCbeta4-deficient mice were analyzed by flow cytometry. (B) Percentages and cell numbers of CD4 + and CD8 + T cells in the splenocytes from WT or PLCbeta4-deficient mice were analyzed by flow... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jul 5, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of experimental medicine','journalText':'The Journal of experimental medicine 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19041_JEM_20201763_FigS2.jpg','benchSciPubmedId':'33970189'},{'sku':'11-0041-82','imageId':'923731','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14878_cells-10-00978-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14878_cells-10-00978-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14878_cells-10-00978-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14878_cells-10-00978-g003.jpg?time\u003d20240507','sortOrder':'39','description':'Figure 3 Biodistribution of virus following treatment. Immunocompromised NOG mice bearing bilateral HapT1 tumors were treated with i.t. injections of TILT-123 or PBS and i.v. injected with hamster TILs loaded with TILT-123 [TILs(TILT-123)], TILT-123, or PBS. DNA was extracted from day 4 snap-frozen ( A ) tumors and ( B ) livers and analyzed for the presence of virus DNA copies (E1A). The virus copy numbers were normalized to the amount of genomic DNA in the samples (GAPDH expression). ( C ) Tumors were collected, processed, and analyzed by flow cytometry for CD4 and CD8 positive cells. Dashed lines indicate the highest average background in control groups for CD8+ and CD4+ cells. Statistically significant differences were found by performing Kruskal Wallis test with Dunn\u0027s multiple comparison test. Only statistically significant differences are shown. Data is presented as mean + SEM; A--animal, T--tumor. *-- p \u003c 0.05.','shortDescription':'Figure 3 Biodistribution of virus following treatment. Immunocompromised NOG mice bearing bilateral HapT1 tumors were treated with i.t. injections of TILT-123 or PBS and i.v. injected with hamster TILs loaded with TILT-123 [TILs(TILT-123)], TILT-123, or PBS. DNA was extracted from day 4 snap-frozen ( A ) tumors and ( B ) livers and analyzed for the presence of virus DNA copies (E1A). The virus copy numbers ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 22, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cells','journalText':'Cells 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14878_cells-10-00978-g003.jpg','benchSciPubmedId':'33922052'},{'sku':'11-0041-82','imageId':'923625','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15116_fimmu-12-642420-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15116_fimmu-12-642420-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15116_fimmu-12-642420-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15116_fimmu-12-642420-g003.jpg?time\u003d20240507','sortOrder':'40','description':'Figure 3 Paclitaxel dysregulates CD4 + and CD8 + T-cell subpopulations in an eIF4E-dependent manner. (A) Gating strategy used for flow cytometry of lymphocytes from popliteal and inguinal lymph nodes. T-cells were separated from the whole lymphoid cells population using CD3. CD3 + cells were then gated for CD4 + T-cell and CD8 + T-cells. For each of these subsets, cells were further gated for CCR7 or CD25 and CD44. (B) Quantification of CD4 + T-cells from the CD3 population from male mice. (C) CCR7 + T-cells from isolated CD4 + population in males, ** p 0.0063. (D) CD4 + cells gated for CD25 and/or CD44 in males. (E) Quantification of CD4 + T-cells from the CD3 + population from female mice, * p 0.0101. (F) CCR7 + T-cells from isolated CD4 + population in female mice, * p 0.0250. (G) CD4 + cells gated for CD25 and/or CD44 in female mice, ** p 0.0011. (H) Quantification of CD8 + T-cells from the CD3 + population from male mice. (I) CCR7 + T-cells from isolated CD8 + population in males, * p 0.0433. (J) CD8 + cells gated for CD25 and/or CD44 in males, * p 0.0396. (K) Quantification of CD8 + T-cells from the CD3 population from female mice, * p 0.041. (L) CCR7 + T-cells from isolated CD8 + population in female mice, ** p 0.0097. (M) CD8 + cells gated for CD25 and/or CD44 in female mice. All data are presented as mean +- standard error of the mean, n \u003d 3 mice each for male/female WT vehicle-treated and WT paclitaxel groups, n \u003d 4 mice each for male/female eIF4E S209A vehicle-trea','shortDescription':'Figure 3 Paclitaxel dysregulates CD4 + and CD8 + T-cell subpopulations in an eIF4E-dependent manner. (A) Gating strategy used for flow cytometry of lymphocytes from popliteal and inguinal lymph nodes. T-cells were separated from the whole lymphoid cells population using CD3. CD3 + cells were then gated for CD4 + T-cell and CD8 + T-cells. For each of these subsets, cells were further gated for CCR7 or CD25 a... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 20, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15116_fimmu-12-642420-g003.jpg','benchSciPubmedId':'33912169'},{'sku':'11-0041-82','imageId':'923604','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14885_fcell-09-629306-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14885_fcell-09-629306-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14885_fcell-09-629306-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14885_fcell-09-629306-g002.jpg?time\u003d20240507','sortOrder':'41','description':'FIGURE 2 A high temperature environment changes the frequencies of Th1 and Th17 cells in the spleen and retinas of EAU mice (day 14 after IRBP immunization). (A) Representative flow cytometry and quantification of IFN-gamma+CD4 + T cells in splenic lymphocytes of EAU mice ( n normal temp \u003d 10, n high temp \u003d 11; mean +- SD; *** p \u003c 0.001; Unpaired t -test). (B) Representative and quantification of IL-17A+CD4 + T cells in the splenic lymphocytes of EAU mice ( n normal temp \u003d 10, n high temp \u003d 11; mean +- SD; ** p \u003c 0.01; Unpaired t -test). (C) The expression of IFN-gamma, IL-17A mRNA were detected by real-time qPCR in splenic lymphocytes from EAU mice housed under normal or high temperature conditions ( n \u003d 5/group; mean +- SD; *** p \u003c 0.001; Unpaired t -test). (D) The expression of IFN-gamma and IL-17A mRNA was detected by real-time qPCR in the retina from EAU mice ( n normal temp \u003d 10; n high temp \u003d 11; data were not normally distributed; median; ** p \u003c 0.01, * p \u003c 0.05; Differences were assessed by Mann Whitney test). (E) Weight of spleens were compared between EAU mice under high or normal temperature housing conditions ( n normal temp \u003d 24, n high temp \u003d 18; mean +- SD; *** p \u003c 0.001; Differences were assessed by Unpaired t -test).','shortDescription':'FIGURE 2 A high temperature environment changes the frequencies of Th1 and Th17 cells in the spleen and retinas of EAU mice (day 14 after IRBP immunization). (A) Representative flow cytometry and quantification of IFN-gamma+CD4 + T cells in splenic lymphocytes of EAU mice ( n normal temp \u003d 10, n high temp \u003d 11; mean +- SD; *** p \u003c 0.001; Unpaired t -test). (B) Representative and quantification of IL-17A+CD4... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 13, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in cell and developmental biology','journalText':'Frontiers in cell and developmental biology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14885_fcell-09-629306-g002.jpg','benchSciPubmedId':'33842459'},{'sku':'11-0041-82','imageId':'923583','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14849_ol-21-05-12670-g03.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14849_ol-21-05-12670-g03.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14849_ol-21-05-12670-g03.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14849_ol-21-05-12670-g03.jpg?time\u003d20240507','sortOrder':'42','description':'Figure 4. Vaccine-induced Th9 differentiation in vitro . Lymphocytes were isolated from the spleen and mesentery lymph nodes of C57/BL6 or ICR mice. Cells were then adjusted to a final density of 2.5x10 6 /ml in culture media, in the presence of 10 ng/ml IL-4 and 5 ng/ml TGF-beta, alone or in combination with 5 ug/ml Hepa1-6 or 10 ug/ml H22 vaccine. After 3 days of culture, the percentage of CD4 + IL-9 + Th9 cells was determined by FCM. Th0 cells were transformed into Th9 cells in the vaccine-only group or in the co-culture with TGF-beta and IL-4 groups. (A) FCM for Th9 cells in two HCC tumor-bearing mouse models. Statistical analysis for the (B) Hepa1-6/C57BL/6 and (C) H22/ICR models. *P\u003c0.05 and **P\u003c0.01. Cellular experiments were repeated \u003e3 times. IL, interleukin; TGF, transforming growth factor; FCM, flow cytometry; Th, helper T; HCC, hepatocellular carcinoma; Ag, whole-cell antigen.','shortDescription':'Figure 4. Vaccine-induced Th9 differentiation in vitro . Lymphocytes were isolated from the spleen and mesentery lymph nodes of C57/BL6 or ICR mice. Cells were then adjusted to a final density of 2.5x10 6 /ml in culture media, in the presence of 10 ng/ml IL-4 and 5 ng/ml TGF-beta, alone or in combination with 5 ug/ml Hepa1-6 or 10 ug/ml H22 vaccine. After 3 days of culture, the percentage of CD4 + IL-9 + Th... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'May 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Oncology letters','journalText':'Oncology letters 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14849_ol-21-05-12670-g03.jpg','benchSciPubmedId':'33841570'},{'sku':'11-0041-82','imageId':'923541','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14884_ijms-22-02765-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14884_ijms-22-02765-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14884_ijms-22-02765-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14884_ijms-22-02765-g003.jpg?time\u003d20240507','sortOrder':'43','description':'Figure 3 Flow cytometric analysis of immune cell populations in the mesenteric lymph nodes (MLN) and spleen of normal and bleomycin (BLM) +- sodium butyrate (SB) mice. BLM was injected subcutaneously for two weeks. SB was administered orally from two weeks before BLM injection. Immune cells were then obtained from the MLN and spleen. ( A ) Flow cytometric gating strategy for macrophage and DC lineages. ( B ) Flow cytometry was used to assess total leukocytes (CD45 + ), macrophages (CD45 + CD64 + CD11b + CX 3 CR1 + ), DCs (CD45 + CD64 - CD11c + MHCII + ), B cells (B220+), and CD4+ T cells in MLN and spleen from normal and BLM +- SB mice. ( C ) Macrophage lineages were subdivided into phase 1 (P1: newly recruited monocytes), phase 2 (P2: maturing monocytes), and phase 3 (P3: monocyte/macrophage intermediates and resident macrophages) following developmental stages. Inflammatory monocytes were defined as both Ly6C + MHCII - (P1) and Ly6C + MHCII + (P2). Representative dot plots, percentages (gated on macrophage lineage) and absolute numbers of inflammatory monocytes are shown in the MLN (upper) and spleen (lower) from normal and BLM +- SB mice. Data are representative of two independent experiments with n \u003d 4-5/group; each symbol represents one mouse. MHCII: Major histocompatibility complex class II. * p \u003c 0.05, ** p \u003c 0.01.','shortDescription':'Figure 3 Flow cytometric analysis of immune cell populations in the mesenteric lymph nodes (MLN) and spleen of normal and bleomycin (BLM) +- sodium butyrate (SB) mice. BLM was injected subcutaneously for two weeks. SB was administered orally from two weeks before BLM injection. Immune cells were then obtained from the MLN and spleen. ( A ) Flow cytometric gating strategy for macrophage and DC lineages. ( B ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Mar 9, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14884_ijms-22-02765-g003.jpg','benchSciPubmedId':'33803282'},{'sku':'11-0041-82','imageId':'923562','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14820_etm-21-05-09914-g03.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14820_etm-21-05-09914-g03.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14820_etm-21-05-09914-g03.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14820_etm-21-05-09914-g03.jpg?time\u003d20240507','sortOrder':'44','description':'Figure 4 Flow cytometric analysis of Th17 cells. CD4-PC5, IL-17A-PC7 and isotype control antibodies were used to determine the proportion of Th17 lymphocytes. (A) Percentage of Th17 cells in WKY-C, WKY-M, and WKY-T groups. (B) Percentage of Th17 cells in week 16 was analyzed using one-way ANOVA with Tukey\u0027s post hoc test. Data are presented as the mean +- standard error of the mean. n\u003d3/group. ** P\u003c0.01 as indicated. C, control; M, methionine; T, treatment; WKY, Wistar-Kyoto; Th17, T helper cell 17.','shortDescription':'Figure 4 Flow cytometric analysis of Th17 cells. CD4-PC5, IL-17A-PC7 and isotype control antibodies were used to determine the proportion of Th17 lymphocytes. (A) Percentage of Th17 cells in WKY-C, WKY-M, and WKY-T groups. (B) Percentage of Th17 cells in week 16 was analyzed using one-way ANOVA with Tukey\u0027s post hoc test. Data are presented as the mean +- standard error of the mean. n\u003d3/group. ** P\u003c0.01 as ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'May 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Experimental and therapeutic medicine','journalText':'Experimental and therapeutic medicine 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14820_etm-21-05-09914-g03.jpg','benchSciPubmedId':'33790992'},{'sku':'11-0041-82','imageId':'923478','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14874_ADVS-8-2003338-g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14874_ADVS-8-2003338-g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14874_ADVS-8-2003338-g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14874_ADVS-8-2003338-g006.jpg?time\u003d20240507','sortOrder':'45','description':'Figure 6 In vivo immunotherapy efficacy of Hb@Hf-Ce6 NPs mediated RT-RDT combined with anti-PD-1 antibody. a) Respective proportion of total macrophages (left column) and M2 phenotype macrophages (right column) in distant tumors. b) Respective proportion of CD4 + T cells (left column) and CD8 + T cells (right column) in distant tumors. c) Representative flow cytometry plots of CD4 + T cells and CD8 + T cells in distant tumors from six groups of mice. d) Respective proportion of regulatory T cells (CD3 + , CD4 + , Foxp3 + ) in distant tumors. e) Respective proportion of effector T cells (CD3 + , CD8 + , IFN gamma + ) in distant tumors. f) Respective proportion of memory T cells (CD3 + , CD8 + , CD62L low , CD44 high ) in spleen. g-k) Cytokine levels of TNF- alpha , IFN- gamma , IL-6, IL-12p70, and IL-10 in serum from mice after various treatments. l) Schematic showed the potential mechanism of Hb@Hf-Ce6 NPs mediated RT-RDT-Immunotherapy for immune response activation to inhibit both primary and distant tumors. Briefly, Hb@Hf-Ce6 NPs accumulated at the tumor site through blood circulation. After X-ray irradiation on the primary tumor, Hb@Hf-Ce6 NPs can not only enhance the RT effect but also activate Ce6 with the assistance of radioluminescence by RDT to generate more ROS. The necrosis tumors in situ activated adaptive and innate immunity and caused a significant proinflammatory response. Furthermore, the anti-PD-1 antibody enhanced the immune response. Activated immunotherapy','shortDescription':'Figure 6 In vivo immunotherapy efficacy of Hb@Hf-Ce6 NPs mediated RT-RDT combined with anti-PD-1 antibody. a) Respective proportion of total macrophages (left column) and M2 phenotype macrophages (right column) in distant tumors. b) Respective proportion of CD4 + T cells (left column) and CD8 + T cells (right column) in distant tumors. c) Representative flow cytometry plots of CD4 + T cells and CD8 + T cell... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Advanced science (Weinheim, Baden-Wurttemberg, Germany)','journalText':'Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14874_ADVS-8-2003338-g006.jpg','benchSciPubmedId':'33643804'},{'sku':'11-0041-82','imageId':'923520','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14875_13287_2021_2159_Fig6_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14875_13287_2021_2159_Fig6_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14875_13287_2021_2159_Fig6_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14875_13287_2021_2159_Fig6_HTML.jpg?time\u003d20240507','sortOrder':'46','description':'Fig. 6 MiR-223 reduced donor T cell migration to recipient mice spleens. The proportion of H2kb + CD4 and CD8 T cell in recipient mice spleens on day 7 was assessed by flow cytometry. Compared with NC and aGvHD group, H2kb + CD4 and H2kb + CD8 cell percentages in miR-223 group showed significant reduction ( a ). The average number of H2kb + CD4 and H2kb + CD8 cells in miR-223 group showed significant decline ( b ). Data were presented as mean +- SEM. Measured in three independent experiments, n \u003d 7 per group. * P \u003c 0.05, ** P \u003c 0.01','shortDescription':'Fig. 6 MiR-223 reduced donor T cell migration to recipient mice spleens. The proportion of H2kb + CD4 and CD8 T cell in recipient mice spleens on day 7 was assessed by flow cytometry. Compared with NC and aGvHD group, H2kb + CD4 and H2kb + CD8 cell percentages in miR-223 group showed significant reduction ( a ). The average number of H2kb + CD4 and H2kb + CD8 cells in miR-223 group showed significant declin... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 26, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Stem cell research \u0026 therapy','journalText':'Stem cell research \u0026 therapy 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14875_13287_2021_2159_Fig6_HTML.jpg','benchSciPubmedId':'33637123'},{'sku':'11-0041-82','imageId':'852079','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9827_abe5819-F2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9827_abe5819-F2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9827_abe5819-F2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9827_abe5819-F2.jpg?time\u003d20240507','sortOrder':'47','description':'Fig. 2 Vaccination with AMP-CpG elicits potent Spike RBD-specific CD8 and CD4 T cells in spleen and blood. C57BL/6 mice ( n \u003d 10 per group) were immunized on days 0, 14, and 28 with 10 mug of Spike RBD protein admixed with 100 mug of alum or 1 nmol soluble CpG or AMP-CpG, and T cell responses were analyzed on day 35. ( A ) Splenocytes were restimulated with overlapping Spike RBD peptides and assayed for IFNgamma production by ELISpot assay. Shown are representative images of ELISpot and frequency of IFNgamma SFCs per 1 x 10 6 splenocytes. ( B and C ) Peripheral blood cells were restimulated with overlapping Spike RBD peptides and assayed by flow cytometry for intracellular cytokine production to detect antigen-specific T cell responses. Shown are frequencies of IFNgamma, TNFalpha, and double-positive T cells among (B) CD8 + and (C) CD4 + T cells, with corresponding representative flow cytometry plots. n \u003d 10 mice per group. Values depicted are means +- standard deviation. ** P \u003c 0.01; *** P \u003c 0.001; **** P \u003c 0.0001 by two-sided Mann-Whitney test applied to cytokine + T cell frequencies.','shortDescription':'Fig. 2 Vaccination with AMP-CpG elicits potent Spike RBD-specific CD8 and CD4 T cells in spleen and blood. C57BL/6 mice ( n \u003d 10 per group) were immunized on days 0, 14, and 28 with 10 mug of Spike RBD protein admixed with 100 mug of alum or 1 nmol soluble CpG or AMP-CpG, and T cell responses were analyzed on day 35. ( A ) Splenocytes were restimulated with overlapping Spike RBD peptides and assayed for IFN... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Science advances','journalText':'Science advances 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9827_abe5819-F2.jpg','benchSciPubmedId':'33547083'},{'sku':'11-0041-82','imageId':'852100','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9827_abe5819-F3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9827_abe5819-F3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9827_abe5819-F3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9827_abe5819-F3.jpg?time\u003d20240507','sortOrder':'48','description':'Fig. 3 Vaccination with AMP-CpG elicits potent lung Spike RBD-specific CD8 and CD4 T cells. C57BL/6 mice ( n \u003d 10 per group) were immunized on days 0, 14, and 28 with 10 mug of Spike RBD protein admixed with 100 mug of alum or 1 nmol soluble CpG or AMP-CpG, and T cell responses were analyzed on day 35. ( A ) Cells collected from perfused lung tissue were restimulated with overlapping Spike RBD peptides and assayed for cytokine production to detect antigen-specific T cell responses. Shown are frequencies (means +- standard deviation) of IFNgamma, TNFalpha, and double-positive T cells among (A) CD8 + and ( B ) CD4 + T cells, with corresponding representative flow cytometry plots. ( C ) Cytokine concentration in supernatants from restimulated lung cells. n \u003d 10 mice per group. Values depicted are means +- standard deviation. **** P \u003c 0.0001 by two-sided Mann-Whitney test applied to cytokine + T cell frequencies or cytokine concentrations.','shortDescription':'Fig. 3 Vaccination with AMP-CpG elicits potent lung Spike RBD-specific CD8 and CD4 T cells. C57BL/6 mice ( n \u003d 10 per group) were immunized on days 0, 14, and 28 with 10 mug of Spike RBD protein admixed with 100 mug of alum or 1 nmol soluble CpG or AMP-CpG, and T cell responses were analyzed on day 35. ( A ) Cells collected from perfused lung tissue were restimulated with overlapping Spike RBD peptides and ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Science advances','journalText':'Science advances 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9827_abe5819-F3.jpg','benchSciPubmedId':'33547083'},{'sku':'11-0041-82','imageId':'852055','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9826_jitc-2020-001932f01.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9826_jitc-2020-001932f01.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9826_jitc-2020-001932f01.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9826_jitc-2020-001932f01.jpg?time\u003d20240507','sortOrder':'49','description':'Figure 1 The phosphotyrosine switch is important for host ERbeta to inhibit tumor growth. (A) Representative genotyping results for WT and mutant allele of WT and KI mice. (B) ERbeta protein levels in mouse bone marrow and spleen (Ponceau S shown as loading control). (C) M-Wnt mammary tumor growth in female WT/KI mice. (D) B16F10 (B16) melanoma growth in WT/KI male mice. (E-H) Flow cytometry of B16 melanoma-infiltrating percentage of CD3 + (of CD45 + ), (E), CD4 + (of CD45 + CD3 + ), (F), CD8 + (of CD45 + CD3 + ), (G), CD11c + (of CD45 + CD3 + ), (H). KI, knock-in; WT, wild-type.','shortDescription':'Figure 1 The phosphotyrosine switch is important for host ERbeta to inhibit tumor growth. (A) Representative genotyping results for WT and mutant allele of WT and KI mice. (B) ERbeta protein levels in mouse bone marrow and spleen (Ponceau S shown as loading control). (C) M-Wnt mammary tumor growth in female WT/KI mice. (D) B16F10 (B16) melanoma growth in WT/KI male mice. (E-H) Flow cytometry of B16 melanoma... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal for immunotherapy of cancer','journalText':'Journal for immunotherapy of cancer 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9826_jitc-2020-001932f01.jpg','benchSciPubmedId':'33462142'},{'sku':'11-0041-82','imageId':'923415','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0008.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0008.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14873_nihms-1642142-f0008.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14873_nihms-1642142-f0008.jpg?time\u003d20240507','sortOrder':'50','description':'Figure 8. G6PD is required for HK2 stable expression and T cell functions. a-c , Whole-cell NADPH concentration ( a ), immunoblot ( b ), right panel in b is a summary graph of densitometric quantification of three independent experiments, and qRT-PCR ( c ) assays using total T cells isolated from wildtype ( G6pd WT ) or G6PD mut mice, in vitro activated with anti-CD3 plus anti-CD28 for 72 h ( a , b ) or as indicated ( c ) ( a , n\u003d2 per genotype; c , n\u003d4 per genotype). d , Immunoblot analysis using lysates of G6PD WT or G6PD mut T cells, stimulated with anti-CD3 plus anti-CD28 for 48 h in the presence (+) or absence (-) of NAM. Right panel is a summary graph of densitometric quantification of two independent experiments (n\u003d4 per genotype). e , Immunoblot analysis using lysates of G6PD mut CD8 + T cells transduced with either a control vector or Flag-G6PD. f,g , Immunoblot ( f ) and flow cytometric analysis of ROS level ( g ) using total T cells isolated from chimeric mice transferred with G6PD WT or G6PD mut bone marrows, in vitro activated with anti-CD3 plus anti-CD28 for 48 h. h , Flow cytometric analysis of CD4 + and CD8 + T cells in the spleen of G6PD WT and G6PD mut mice. i , ELISA of IFN-gamma and IL-2 in the supernatant of G6PD WT and G6PD mut CD8 + T cell cultures stimulated with anti-CD3 plus anti-CD28 for 66 h. j , CoIP analysis of endogenous NIK-G6PD interaction using whole-cell lysates of CD8 + T cells isolated from NIK iTg mice and activated for 48 h with anti-CD3','shortDescription':'Figure 8. G6PD is required for HK2 stable expression and T cell functions. a-c , Whole-cell NADPH concentration ( a ), immunoblot ( b ), right panel in b is a summary graph of densitometric quantification of three independent experiments, and qRT-PCR ( c ) assays using total T cells isolated from wildtype ( G6pd WT ) or G6PD mut mice, in vitro activated with anti-CD3 plus anti-CD28 for 72 h ( a , b ) or as ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature immunology','journalText':'Nature immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14873_nihms-1642142-f0008.jpg','benchSciPubmedId':'33398181'},{'sku':'11-0041-82','imageId':'923331','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14873_nihms-1642142-f0001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14873_nihms-1642142-f0001.jpg?time\u003d20240507','sortOrder':'51','description':'Figure 1. T cell-specific deletion of NIK impairs antitumor immunity. a, Tumor growth curve of Map3k14 tKO (tKO) and wildtype (WT) control mice injected s.c. with 2 x 10 5 B16F10 melanoma cells. b , c , Flow cytometric analysis of the frequency and absolute cell number of CD4 + and CD8 + T cells ( b ) and IFN-gamma-producing CD8 + effector T cells ( c ) in the tumor of day16 B16F10-implanted Map3k14 tKO and wildtype mice ( b , c , n\u003d6 per genotype). d - f , Flow cytometric analysis of the frequency and absolute number of CD4 + and CD8 + T cells in the draining lymph node ( d ), CD44 + CXCR3 + CD8 + effector T cells in the draining lymph node ( e ), and CD44 + CXCR3 + CD8 + effector T cells in the tumor ( f ) of day16 B16F10-implanted Map3k14 tKO and wildtype control mice ( d , n\u003d6 per genotype; e , f , n\u003d5 per genotype). g , Flow cytometrc analysis of tumor-infiltrating wildtype and Map3k14 tKO OT-I CD8 + T cells in B16-OVA-tumor bearing B6 mice adoptively transferred (on day 17) with a mixture (1:1 ratio) of in vitro activated wildtype (CMTMR labeled) and Map3k14 tKO (CFSE labeled) OT-I CD8 + T cells (n\u003d6 per group). h , i , Flow cytometric analysis of apoptosis based on caspase 3 cleavage ( h ) and proliferation based on CFSE dilution ( i ) of tumor-infiltrating wildtype and Map3k14 tKO OT-I CD8 + T cells in B16-OVA-tumor bearing B6.SJL mice adoptively transferred on day 14 with in vitro activated and CFSE-labeled wildtype and Map3k14 tKO CD8 + T cells for 7 days; n\u003d3 per g','shortDescription':'Figure 1. T cell-specific deletion of NIK impairs antitumor immunity. a, Tumor growth curve of Map3k14 tKO (tKO) and wildtype (WT) control mice injected s.c. with 2 x 10 5 B16F10 melanoma cells. b , c , Flow cytometric analysis of the frequency and absolute cell number of CD4 + and CD8 + T cells ( b ) and IFN-gamma-producing CD8 + effector T cells ( c ) in the tumor of day16 B16F10-implanted Map3k14 tKO and... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature immunology','journalText':'Nature immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14873_nihms-1642142-f0001.jpg','benchSciPubmedId':'33398181'},{'sku':'11-0041-82','imageId':'923352','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14873_nihms-1642142-f0002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14873_nihms-1642142-f0002.jpg?time\u003d20240507','sortOrder':'52','description':'Figure 2. Ectopic expression of NIK prevents T cell exhaustion and promotes antitumor immunity. a-c , Tumor growth curve ( a ), image of day 32 tumors ( b ), and survival curve ( c ) of the MC38-bearing NIK iTg and wildtype control mice. d , e , Tumor growth ( d ) and survival ( e ) curves of NIK iTg and wildtype control mice injected s.c. with 5 x 10 5 B16F10 melanoma cells. f , g , Flow cytometric analysis of the frequency and absolute cell number of CD4 + and CD8 + T cells ( f ) and IFN-gamma-producing CD8 + effector T cells ( g ) in day-32 tumor of MC38-bearing NIK iTg and wildtype control mice ( f , g , n\u003d6 per genotype). h-j , Flow cytometric analysis of the frequency and absolute cell number of CD4 + and CD8 + T cells in the draining lymph node ( h ) and CD44 + CXCR3 + CD8 + effector T cells in the draining lymph node ( i ) or tumor ( j ) of day-32 MC38-implanted NIK iTg and wildtype control mice ( h , n\u003d6 per group; i , n\u003d4 per group; j , n\u003d3 per group). k , l , Flow cytometric analysis of the frequency and absolute cell number of PD1 + Tim3 + and PD1 + Tim3 - CD8 + T cells ( k ) and IFN-gamma-producing gated PD1 + Tim3 + CD8 + T cells ( l ) in day-32 tumor of the MC38-bearing wildtype or iTg mice ( k , l , n\u003d6 per genotype). m , n , Flow cytometry ( m ) and qRT-PCR ( n ) analyses of PD1 and Tim3 expression level in tumor-infiltrating PD1 + Tim3 + CD8 + T cells of MC38-bearing (day 32) wildtype or iTg mice ( n , WT: n\u003d2; NIK iTg : n\u003d3) . o , Schematic of experimental','shortDescription':'Figure 2. Ectopic expression of NIK prevents T cell exhaustion and promotes antitumor immunity. a-c , Tumor growth curve ( a ), image of day 32 tumors ( b ), and survival curve ( c ) of the MC38-bearing NIK iTg and wildtype control mice. d , e , Tumor growth ( d ) and survival ( e ) curves of NIK iTg and wildtype control mice injected s.c. with 5 x 10 5 B16F10 melanoma cells. f , g , Flow cytometric analysi... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature immunology','journalText':'Nature immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14873_nihms-1642142-f0002.jpg','benchSciPubmedId':'33398181'},{'sku':'11-0041-82','imageId':'923436','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0009.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0009.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14873_nihms-1642142-f0009.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14873_nihms-1642142-f0009.jpg?time\u003d20240507','sortOrder':'53','description':'Extended Data Fig. 1 NIK regulates T cell exhaustion and antitumor immunity a, genotyping PCR of R26Stop FL Map3k14 (Map3k14 Tg ), Map3k14 +/+ CreER, and R26Stop FL Map3k14 -CreER ( Map3k14 Tg CreER) mice, showing the PCR products of NIK-GFP in Map3k14 Tg allele and CreER. b, Immunoblot analysis of NIK expression in tamoxifen-treated Map3k14 +/+ CreER (WT) and Map3k14 Tg CreER (iTg) mice. c, Schematic of experimental design for producing B16F10 tumor-bearing NIK iTg and WT control mice. Each mouse was injected s.c. with 5 x 10 5 B16F10 cells (WT\u003d9, iTg\u003d7). d,e, Flow cytometric analysis of the frequency and absolute cell number of CD4 and CD8 T cells in the tumor (d) or draining lymph node (e) of day 18 B16F10 tumor-implanted NIK-iTg and WT mice ( d , WT: n\u003d4; iTg: n\u003d5; e , n\u003d6 per genotype). f,g, Flow cytometric analysis of the frequency and absolute number of CD44 + CXCR3 + CD8 effector T cells in the draining lymph node ( f ) or tumor ( g ) of day 18 B16F10 tumor-implanted NIK-iTg and wildtype mice ( f , n\u003d6 per genotype; g, n\u003d4 per genotype). h,i, Flow cytometric analysis of the frequency and absolute number of PD1 + Tim3 + CD8 + T cells ( h ) or IFNgamma-producing PD1 + Tim3 + CD8 T cells ( i ) in the tumor of day 18 B16F10-implanted NIK iTg and wildtype control mice (h,i, n\u003d4 per genotype). Data are representative of three independent experiments. Summary data are shown as mean +- s.e.m. with P values determined by two-tailed Student\u0027s t test.','shortDescription':'Extended Data Fig. 1 NIK regulates T cell exhaustion and antitumor immunity a, genotyping PCR of R26Stop FL Map3k14 (Map3k14 Tg ), Map3k14 +/+ CreER, and R26Stop FL Map3k14 -CreER ( Map3k14 Tg CreER) mice, showing the PCR products of NIK-GFP in Map3k14 Tg allele and CreER. b, Immunoblot analysis of NIK expression in tamoxifen-treated Map3k14 +/+ CreER (WT) and Map3k14 Tg CreER (iTg) mice. c, Schematic of ex... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature immunology','journalText':'Nature immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14873_nihms-1642142-f0009.jpg','benchSciPubmedId':'33398181'},{'sku':'11-0041-82','imageId':'923373','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14873_nihms-1642142-f0005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14873_nihms-1642142-f0005.jpg?time\u003d20240507','sortOrder':'54','description':'Figure 5. HK2 is required for antitumor immunity. a , b , Tumor growth ( a ) and survival ( b ) curves of Hk2 tKO or wildtype (WT) control mice injected s.c. with 10 5 B16F10 melanoma cells for the indicated time periods. c , d , Flow cytometric analysis of the frequency and absolute number of CD4 + and CD8 + T cells ( c ) and IFN-gamma-producing CD8 + effector T cells ( d ) in day 20 tumor of the B16F10-implanted Hk2 tKO and wildtype control mice ( c ,WT: n\u003d9; Hk2 tKO : n\u003d8; d , n\u003d5 per genotype). e , Tumor growth curve of MC38 tumor-bearing wildtype, NIK iTg (iTg), and NIK iTg Hk2 iKO (iTg-iKO) mice. f,g, Flow cytometric analysis of the frequency and absolute cell number of IFN-gamma-producing CD8 + T cells ( f ) and gated PD1 + Tim3 + CD8 + T cells ( g ) in day-27 tumor of the MC38 tumor-bearing mice ( f , g , WT: n\u003d4, iTg: n\u003d4, iTg-iKO: n\u003d3) . Data are representative of two ( e-g ) or three ( a-d ) independent experiments. Flow cytometry data are presented as representative plots (left) and summary graphs (mean +- s.e.m.) based on multiple mice (right, each circle represents an individual mouse). P values were determined by two-way analysis of ANOVA with Bonferroni correction ( a , e ), two-tailed Student\u0027s t test ( c , d , f,g ) or two sided log- rank test ( b ).','shortDescription':'Figure 5. HK2 is required for antitumor immunity. a , b , Tumor growth ( a ) and survival ( b ) curves of Hk2 tKO or wildtype (WT) control mice injected s.c. with 10 5 B16F10 melanoma cells for the indicated time periods. c , d , Flow cytometric analysis of the frequency and absolute number of CD4 + and CD8 + T cells ( c ) and IFN-gamma-producing CD8 + effector T cells ( d ) in day 20 tumor of the B16F10-im... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature immunology','journalText':'Nature immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14873_nihms-1642142-f0005.jpg','benchSciPubmedId':'33398181'},{'sku':'11-0041-82','imageId':'923394','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14873_nihms-1642142-f0006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14873_nihms-1642142-f0006.jpg?time\u003d20240507','sortOrder':'55','description':'Figure 6. HK2 deletion blocks the autoimmune phenotype of NIK tTg mice. a, Body weight of 36-day old wildtype (WT), NIK tTg (tTg), and NIK tTg Hk tKO (tTg-tKO) littermate mice (WT: n\u003d5, tTg: n\u003d8, tTg-tKO: n\u003d7) . b , Image of inguinal lymph nodes and thymi of four pairs of mice with the indicated genotypes. c , H\u0026E staining of colon and lung sections from moribund NIK tTg , NIK tTg Hk tKO and age-matched littermate wildtype control mice were assessed for leukocyte infiltrates by hematoxylin-eosin stain. Scale bars: 100 mum. (n\u003d3 in each group). d-g , Flow cytometric analysis of the frequency and absolute cell number of double-negative (DN), double-positive (DP), CD8 + single-positive (SP), and CD4 + SP thymocytes ( d ), thymic CD25 + foxp3 + T reg cells ( e ), lymph node CD25 + foxp3 + T reg cells ( f ), and lymph node CD44 - foxp3 + T reg cells ( g ) in NIK tTg , NIK tTg Hk tKO or wildtype mice ( e-f , NIK iTg : n\u003d6, NIK tTg Hk tKO : n\u003d4, wildtype: n\u003d5). Data are representative of two ( a-c , e-g ) or three ( d ) independent experiments. Summary data are shown as mean +- s.e.m. with P values determined by two-tailed Student\u0027s t test ( a , d-g ) .','shortDescription':'Figure 6. HK2 deletion blocks the autoimmune phenotype of NIK tTg mice. a, Body weight of 36-day old wildtype (WT), NIK tTg (tTg), and NIK tTg Hk tKO (tTg-tKO) littermate mice (WT: n\u003d5, tTg: n\u003d8, tTg-tKO: n\u003d7) . b , Image of inguinal lymph nodes and thymi of four pairs of mice with the indicated genotypes. c , H\u0026E staining of colon and lung sections from moribund NIK tTg , NIK tTg Hk tKO and age-matched lit... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature immunology','journalText':'Nature immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14873_nihms-1642142-f0006.jpg','benchSciPubmedId':'33398181'},{'sku':'11-0041-82','imageId':'923457','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0013.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0013.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14873_nihms-1642142-f0013.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14873_nihms-1642142-f0013.jpg?time\u003d20240507','sortOrder':'56','description':'Extended Data Fig. 5 NIK-mediated stimulation of antitumor T cell responses requires HK2 Flow cytometric analysis of the frequency and absolute cell number of CD4 and CD8 T cells ( a ), PD1 + Tim3 + CD8 T cells ( b ) and flow cytometric analysis of the expression level (MFI) of PD1 and Tim3 in CD8 T cells ( c ) in day-27 tumor of wildtype (WT), NIK iTg (iTg), NIK iTg Hk2 iKO (iTg-iKO) mice injected s.c. with 5 x 10 5 /mouse MC38 colon cancer cells ( a,b, WT: n\u003d4; iTg: n\u003d4; iTg-iKO: n\u003d3). Data are representative of two independent experiments. Summary data are shown as mean +- s.e.m. with P values were determined by two-tailed Student\u0027s t test.','shortDescription':'Extended Data Fig. 5 NIK-mediated stimulation of antitumor T cell responses requires HK2 Flow cytometric analysis of the frequency and absolute cell number of CD4 and CD8 T cells ( a ), PD1 + Tim3 + CD8 T cells ( b ) and flow cytometric analysis of the expression level (MFI) of PD1 and Tim3 in CD8 T cells ( c ) in day-27 tumor of wildtype (WT), NIK iTg (iTg), NIK iTg Hk2 iKO (iTg-iKO) mice injected s.c. wit... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature immunology','journalText':'Nature immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14873_nihms-1642142-f0013.jpg','benchSciPubmedId':'33398181'},{'sku':'11-0041-82','imageId':'1018642','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15659_ppat.1009136.g010.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15659_ppat.1009136.g010.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15659_ppat.1009136.g010.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15659_ppat.1009136.g010.jpg?time\u003d20240507','sortOrder':'57','description':'10.1371/journal.ppat.1009136.g010 Fig 10 SAG-induced Runx-dependent CD40 upregulation on DCs promotes type-1 T cell response in LD-infected mice. Runx1- and Runx3-silenced BMDCs (with or without CD40 overexpression), and control-silenced BMDCs were treated with SAG and then adoptively transferred into LD-infected mice. Alternatively, age-matched uninfected and LD-infected mice were left without any DC transfer (details given in Fig 9 legend). (A and B) Frequency of IFNgamma- and IL-10-producing CD4 + (A) or CD8 + (B) T cells in splenocytes isolated from these mice, assessed by flow cytometry (representative data of n \u003d 6). Numbers indicate the percentage of cells in the respective quadrants. Gating strategy used for flow cytometry analysis is described in S19 Fig . (C) Graphs displaying cumulative data of the percentage of IFNgamma- and IL-10-producing CD4 + (upper panels) or CD8 + (lower panels) T cells from two independent experiments ( n \u003d 3 mice per group in each experiment). Each symbol represents an individual mouse; horizontal bars represent the mean. In all experiments, LD strain AG83 was used. * p \u003c 0.001, ** p \u003c 0.01, *** p \u003c 0.05; NS, not significant.','shortDescription':'10.1371/journal.ppat.1009136.g010 Fig 10 SAG-induced Runx-dependent CD40 upregulation on DCs promotes type-1 T cell response in LD-infected mice. Runx1- and Runx3-silenced BMDCs (with or without CD40 overexpression), and control-silenced BMDCs were treated with SAG and then adoptively transferred into LD-infected mice. Alternatively, age-matched uninfected and LD-infected mice were left without any DC trans... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PLoS pathogens','journalText':'PLoS pathogens 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15659_ppat.1009136.g010.jpg','benchSciPubmedId':'33370418'},{'sku':'11-0041-82','imageId':'923310','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14883_gr2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14883_gr2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14883_gr2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14883_gr2.jpg?time\u003d20240507','sortOrder':'58','description':'Figure 2 NK Cells Contribute to Both Innate and Adaptive Immune Control of Ptgs -/- Tumors (A) Growth profile of Ptgs +/+ and Ptgs -/- melanoma cells implanted into Rag1 -/- or wild-type mice untreated or depleted of NK, CD4 + , and/or CD8 + cells. (B and C) Frequency of CD8 + T cells (B); representative plots and frequency of CD8 + CD44 + , CD8 + IFNgamma + , and CD4 + IFNgamma + T cells (C) gated on live, CD45 + , CD3epsilon + cells in Ptgs +/+ and Ptgs -/- untreated or NK cell-depleted wild-type mice analyzed 7 days post-implantation. (D) Individual growth profiles of Ptgs -/- melanoma cells in wild-type mice depleted of NK cells from the day before or a week after cancer cell implantation. (E) Growth profile of Ptgs +/+ and Ptgs -/- cells in wild-type mice or Ptgs +/+ cells in GPP mice. (F) Tumor weight, NK cell frequency, and number per g of tumor analyzed 4 days after implantation of Ptgs +/+ and Ptgs -/- cells in wild-type or Ptgs +/+ cells in GPP mice. (G) Growth profile of Ptgs +/+ and Ptgs -/- melanoma cells in wild-type or Ptgs +/+ melanoma cells in Ptger2 -/- or Gzmb-Cre Ptger4 floxed/floxed mice. Data are expressed as mean +- SEM, one-way (B-C and F) or two-way ANOVA (A).','shortDescription':'Figure 2 NK Cells Contribute to Both Innate and Adaptive Immune Control of Ptgs -/- Tumors (A) Growth profile of Ptgs +/+ and Ptgs -/- melanoma cells implanted into Rag1 -/- or wild-type mice untreated or depleted of NK, CD4 + , and/or CD8 + cells. (B and C) Frequency of CD8 + T cells (B); representative plots and frequency of CD8 + CD44 + , CD8 + IFNgamma + , and CD4 + IFNgamma + T cells (C) gated on live,... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Dec 15, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Immunity','journalText':'Immunity 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14883_gr2.jpg','benchSciPubmedId':'33220234'},{'sku':'11-0041-82','imageId':'850356','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8286_jcmm15942-fig-0002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8286_jcmm15942-fig-0002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8286_jcmm15942-fig-0002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8286_jcmm15942-fig-0002.jpg?time\u003d20240507','sortOrder':'59','description':'2 FIGURE Effects of DTA-64 inflammatory cells infiltration and NF-kappaB signalling pathway in the lung. (A) H\u0026E staining for inflammatory cell infiltration (x200 magnification, scale bar: 5mum). (B) The gating strategy of total cells, eosinophils and neutrophils in the BALF. Granulocytes in the BALF were gated based on the CD45.2 + properties. Within the CD45.2 gate, CD45.2+/CD11b+/ly6G+, CD45.2+/Siglec-F + cells and CD3e+/CD4+ cells represented the eosinophils, neutrophils and T cells, respectively. (C) The numbers of total cells, eosinophil (EOS), neutrophil (Neu) and T cells (Lym). (D) The production of NF-kappaB p65 (nuclear), NF-kappaB (cytosol), p-IkappaBalpha and IkappaBalpha in the lung homogenates was estimated by western blotting, and the relative density (E) was measured. (F) Immunofluorescence assay for NF-kappaB p65 in the lung sections was performed. All data were shown as mean +- SD (n \u003d 3). * P \u003c 0.05, ** P \u003c 0.01 vs control group. # P \u003c 0.05, ## P \u003c 0.01 vs OVA group','shortDescription':'2 FIGURE Effects of DTA-64 inflammatory cells infiltration and NF-kappaB signalling pathway in the lung. (A) H\u0026E staining for inflammatory cell infiltration (x200 magnification, scale bar: 5mum). (B) The gating strategy of total cells, eosinophils and neutrophils in the BALF. Granulocytes in the BALF were gated based on the CD45.2 + properties. Within the CD45.2 gate, CD45.2+/CD11b+/ly6G+, CD45.2+/Siglec-F ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of cellular and molecular medicine','journalText':'Journal of cellular and molecular medicine 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8286_jcmm15942-fig-0002.jpg','benchSciPubmedId':'33124760'},{'sku':'11-0041-82','imageId':'850381','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8286_jcmm15942-fig-0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8286_jcmm15942-fig-0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8286_jcmm15942-fig-0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8286_jcmm15942-fig-0003.jpg?time\u003d20240507','sortOrder':'60','description':'3 FIGURE Effects of DTA-64 on the Th1/Th2/Th17 balance in vivo. Flow cytometric analysis of CD4 + T cell and Th1/Th2/Th17 subtypes was performed in BAL cells, mLNs and splenocytes. (A) CD3e+/CD4+ cells in the BAL cells, mLNs and splenocytes were selected. (B) Proportion of CD3e+/CD4+ cells was displayed by histogram. (C) Th1/Th2/Th17 cytokines within the CD3e+ CD4+ cells in the BAL cells were selected. (D) Levels of IL-4, IL-17 or IFN-gamma secreting cells within the CD3e+/CD4+ cells were shown by histogram. (E) Production of IL-4, IL-17 and IFN-gamma was measured by ELISA. (F) The photograph of mLNs in the group mice. Arrows indicate the mLN. (G) Proportion of IL-4, IL-17 and IFN-gamma-positive cells in the CD3e+/CD4+ cells were displayed by histogram. All data were shown as mean +- SD * P \u003c 0.05, ** P \u003c 0.01 vs control group. # P \u003c .05, ## P \u003c 0.01 vs OVA group','shortDescription':'3 FIGURE Effects of DTA-64 on the Th1/Th2/Th17 balance in vivo. Flow cytometric analysis of CD4 + T cell and Th1/Th2/Th17 subtypes was performed in BAL cells, mLNs and splenocytes. (A) CD3e+/CD4+ cells in the BAL cells, mLNs and splenocytes were selected. (B) Proportion of CD3e+/CD4+ cells was displayed by histogram. (C) Th1/Th2/Th17 cytokines within the CD3e+ CD4+ cells in the BAL cells were selected. (D) ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of cellular and molecular medicine','journalText':'Journal of cellular and molecular medicine 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8286_jcmm15942-fig-0003.jpg','benchSciPubmedId':'33124760'},{'sku':'11-0041-82','imageId':'923289','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14882_cells-09-02068-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14882_cells-09-02068-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14882_cells-09-02068-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14882_cells-09-02068-g001.jpg?time\u003d20240507','sortOrder':'61','description':'Figure 1 Truncated PPM1D impairs DNA damage response in mouse thymus. Expression of PPM1D mRNA was analyzed by RT-qPCR in the thymi of Ppm1d +/+ , Ppm1d T/+ and Ppm1d T/T mice and was normalized to GAPDH ( n \u003d 3) ( A ). Thymi from mice of indicated genotypes were lysed and proteins were separated by SDS-PAGE. Samples were probed with antibody against PPM1D and importin-beta as a loading control. The empty and full arrowheads indicate the position of the full-length and the C-terminally truncated PPM1D, respectively. ( B ). Cells from thymi from Ppm1d +/+ and Ppm1d T/+ mice were analyzed by flow cytometry. Plotted are the counts of the indicated populations as follows: double-negative T-cells (DN and DN1, DN2, DN3, DN4), double-positive T-cells (DP), CD8-positive T-cells (CD8+) and CD4-positive T-cells (CD4+) ( n \u003d 3) ( C ). The median size of the thymus was determined in Ppm1d +/+ ( n \u003d 11) and Ppm1d T/+ ( n \u003d 12) mice ( D ). A scheme of the experimental setup in F-I. Mice were exposed or not to a low dose of IR (3 Gy), sacrificed after 6 h and thymi and lymph nodes were collected ( E ). Proteins isolated from thymi from mice of indicated genotypes exposed to mock or to IR were probed with the indicated antibodies by immunoblotting ( F ). Proteins isolated from inguinal lymph nodes from mice of indicated genotypes exposed to mock or to IR were probed with the indicated antibodies by immunoblotting ( G ). RNA isolated from thymi from mice in E was analyzed by RT-qPCR. The expr','shortDescription':'Figure 1 Truncated PPM1D impairs DNA damage response in mouse thymus. Expression of PPM1D mRNA was analyzed by RT-qPCR in the thymi of Ppm1d +/+ , Ppm1d T/+ and Ppm1d T/T mice and was normalized to GAPDH ( n \u003d 3) ( A ). Thymi from mice of indicated genotypes were lysed and proteins were separated by SDS-PAGE. Samples were probed with antibody against PPM1D and importin-beta as a loading control. The empty a... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 10, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cells','journalText':'Cells 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14882_cells-09-02068-g001.jpg','benchSciPubmedId':'32927737'},{'sku':'11-0041-82','imageId':'988104','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24327_NeuralRegenRes_2021_16_2_382_290910_f3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24327_NeuralRegenRes_2021_16_2_382_290910_f3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24327_NeuralRegenRes_2021_16_2_382_290910_f3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24327_NeuralRegenRes_2021_16_2_382_290910_f3.jpg?time\u003d20240507','sortOrder':'62','description':'Figure 3 T-cell subsets derived from splenocytes using flow cytometric analysis during the 14 days after spinal cord injury. (A, B) Percentage of gated CD4 + T-cells, following stimulation, compared with the unstimulated control. (C) Percentage of CD4 + IFN-gamma + T-helper cells, in response to stimulation. CD4 + IFN-gamma + T-cells in the spleen demonstrated a sharp decline within 3-7 days after surgery. (D) Percentage of CD4 + IL17A + T-helper cells in response to stimulation. The percentage of CD4 + IL17A + T-cells increased 7 days after surgery. (E) Percentage of CD4 + IFN-gamma + IL17A + T-cells, in response to stimulation. (F, H) Percentage of gated CD4 + T-cells, compared with control. (G) Percentage of CD4 + CD25 + FoxP3 + regulatory T-cells. Regulatory T-cell numbers presented a sharp increase in the spleen 3 days post-injury, and then gradually declined. Data are expressed as the mean +- SEM ( n \u003d 6; one-way analysis of variance followed by Tukey\u0027s post hoc test). * P \u003c 0.05, ** P \u003c 0.01, *** P \u003c 0.001. FoxP3: Forkhead box P3; FSC: forward scatter; IFN-gamma: interferon-gamma; IL17A: interleukin 17A; SSC: side scatter. Figure 3','shortDescription':'Figure 3 T-cell subsets derived from splenocytes using flow cytometric analysis during the 14 days after spinal cord injury. (A, B) Percentage of gated CD4 + T-cells, following stimulation, compared with the unstimulated control. (C) Percentage of CD4 + IFN-gamma + T-helper cells, in response to stimulation. CD4 + IFN-gamma + T-cells in the spleen demonstrated a sharp decline within 3-7 days after surgery. ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Neural regeneration research','journalText':'Neural regeneration research 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24327_NeuralRegenRes_2021_16_2_382_290910_f3.jpg','benchSciPubmedId':'32859802'},{'sku':'11-0041-82','imageId':'923499','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19040_NRR-16-382-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19040_NRR-16-382-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19040_NRR-16-382-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19040_NRR-16-382-g004.jpg?time\u003d20240507','sortOrder':'63','description':'Figure 3 T-cell subsets derived from splenocytes using flow cytometric analysis during the 14 days after spinal cord injury. (A, B) Percentage of gated CD4 + T-cells, following stimulation, compared with the unstimulated control. (C) Percentage of CD4 + IFN-gamma + T-helper cells, in response to stimulation. CD4 + IFN-gamma + T-cells in the spleen demonstrated a sharp decline within 3-7 days after surgery. (D) Percentage of CD4 + IL17A + T-helper cells in response to stimulation. The percentage of CD4 + IL17A + T-cells increased 7 days after surgery. (E) Percentage of CD4 + IFN-gamma + IL17A + T-cells, in response to stimulation. (F, H) Percentage of gated CD4 + T-cells, compared with control. (G) Percentage of CD4 + CD25 + FoxP3 + regulatory T-cells. Regulatory T-cell numbers presented a sharp increase in the spleen 3 days post-injury, and then gradually declined. Data are expressed as the mean +- SEM ( n \u003d 6; one-way analysis of variance followed by Tukey\u0027s post hoc test). * P \u003c 0.05, ** P \u003c 0.01, *** P \u003c 0.001. FoxP3: Forkhead box P3; FSC: forward scatter; IFN-gamma: interferon-gamma; IL17A: interleukin 17A; SSC: side scatter.','shortDescription':'Figure 3 T-cell subsets derived from splenocytes using flow cytometric analysis during the 14 days after spinal cord injury. (A, B) Percentage of gated CD4 + T-cells, following stimulation, compared with the unstimulated control. (C) Percentage of CD4 + IFN-gamma + T-helper cells, in response to stimulation. CD4 + IFN-gamma + T-cells in the spleen demonstrated a sharp decline within 3-7 days after surgery. ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Neural regeneration research','journalText':'Neural regeneration research 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19040_NRR-16-382-g004.jpg','benchSciPubmedId':'32859802'},{'sku':'11-0041-82','imageId':'923710','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14877_hum.2020.050_figure5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14877_hum.2020.050_figure5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14877_hum.2020.050_figure5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14877_hum.2020.050_figure5.jpg?time\u003d20240507','sortOrder':'64','description':'Figure 5. Increased tumor-infiltrating T cell populations upon treatment with KLS-3010. Tumor-infiltrating T cells were analyzed on day 5 postadministration. The percentages of CD8 + (A) , CD8 + IFN-gamma + (B) , CD4 + (C) , CD4 + IFN-gamma + (D) , and regulatory (E) T cells were determined by flow cytometry. Data are shown as mean +- standard error ( n \u003d 5 mice/group). * p \u003c 0.05.','shortDescription':'Figure 5. Increased tumor-infiltrating T cell populations upon treatment with KLS-3010. Tumor-infiltrating T cells were analyzed on day 5 postadministration. The percentages of CD8 + (A) , CD8 + IFN-gamma + (B) , CD4 + (C) , CD4 + IFN-gamma + (D) , and regulatory (E) T cells were determined by flow cytometry. Data are shown as mean +- standard error ( n \u003d 5 mice/group). * p \u003c 0.05.','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'May 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Human gene therapy','journalText':'Human gene therapy 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14877_hum.2020.050_figure5.jpg','benchSciPubmedId':'32854548'},{'sku':'11-0041-82','imageId':'851611','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9817_jciinsight-5-136773-g165.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9817_jciinsight-5-136773-g165.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9817_jciinsight-5-136773-g165.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9817_jciinsight-5-136773-g165.jpg?time\u003d20240507','sortOrder':'65','description':'Figure 1 Lymphocytes make up the main immune population within digested GCT. Viable single tumor cell suspension and PBMCs from healthy donors were analyzed using polychromatic flow cytometry and progressive gating strategy. ( A ) Representative staining with CD3, CD4, CD8, CD25, CD45, and FOXP3 used to quantify helper (CD4 + ), cytotoxic (CD8 + ), and regulatory (Tregs) (CD4 + CD25 + FOXP3 + ) T cells in a GCT sample. ( B-D ) Representative staining with CD11b, HLA-DR, CD11c, Lineage, CD14, CD15, and CD33 used to identify the myeloid populations in a GCT sample. Tumor-associated macrophages (TAMs)/monocytes were separated from DC based on CD14 expression ( C ). Myeloid-derived suppressor cells (MDSC) were separated as eMDSC based on Lineage, HLA-DR, CD11b, and CD33 markers ( B ), whereas PMN-MDSC were characterized as CD15 + CD14 - CD11b + ( D ). Proportions of tumor-infiltrating immune cells in GCT were quantified as percentage of total cell suspension. ( E ) Percentages of CD4 + T cells, CD8 + T cells, and Tregs compared with total tumor cell suspension. ( F ) Comparison of PD1-expressing T cells in the GCT vs. PBMCs. ( G ) CD8 + T cells/Tregs ratio in GCT vs. PBMCs. ( H ) Percentage of TAMs/monocytes, DC, PMN-MDSC, and eMDSC of total tumor cell suspension. Mean +- SEM is shown. Each dot represents a patient ( n \u003d 7) or healthy control PBMCs ( n \u003d 3).','shortDescription':'Figure 1 Lymphocytes make up the main immune population within digested GCT. Viable single tumor cell suspension and PBMCs from healthy donors were analyzed using polychromatic flow cytometry and progressive gating strategy. ( A ) Representative staining with CD3, CD4, CD8, CD25, CD45, and FOXP3 used to quantify helper (CD4 + ), cytotoxic (CD8 + ), and regulatory (Tregs) (CD4 + CD25 + FOXP3 + ) T cells in a... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Aug 20, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9817_jciinsight-5-136773-g165.jpg','benchSciPubmedId':'32814714'},{'sku':'11-0041-82','imageId':'851745','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9817_jciinsight-5-136773-g170.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9817_jciinsight-5-136773-g170.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9817_jciinsight-5-136773-g170.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9817_jciinsight-5-136773-g170.jpg?time\u003d20240507','sortOrder':'66','description':'Figure 6 Vaccination with FoxL2-TT reduced tumor progression. ( A ) Healthy organs and tissues were collected from 3 mice, pooled together. RNA was extracted using Trizol, and foxl2 fold expression was calculated by real-time PCR. Mean +- SEM is shown. ( B and C ) T cells from FVB and BALB/c vaccinated mice were cocultured with BR5-FOXL2 and BR5 WT ( B ) and with IFN-gamma-pretreated 4T1-FOXL2 and 4T1 WT ( C ). ( D and F ) FVB and BALB/c were injected s.c. with 1 x 10 6 BR5-FOXL2 ( D ) and 2.5 x 10 5 4T1-FOXL2 ( F ) and, 3 days later, injected 3 times with FoxL2-TT or empty pVAX (CTRL) vaccines followed by electroporation. Data are shown as mean +- SEM ( n \u003d 8-10 mice per group) from 1 of 3 experiments. Two-way ANOVA analyses were performed for tumor growth experiments. Percentage of tumor-infiltrating CD8 + and CD4 + T cells were calculated by flow cytometry at day 25. ( E and G ) Each dot represents a mouse, n \u003d 6-3 mice per group ( E ) and n \u003d 5 mice per group ( G ). Mean +- SEM is shown. Two-tailed t test analyses were performed. * P \u003c 0.05, ** P \u003c 0.01.','shortDescription':'Figure 6 Vaccination with FoxL2-TT reduced tumor progression. ( A ) Healthy organs and tissues were collected from 3 mice, pooled together. RNA was extracted using Trizol, and foxl2 fold expression was calculated by real-time PCR. Mean +- SEM is shown. ( B and C ) T cells from FVB and BALB/c vaccinated mice were cocultured with BR5-FOXL2 and BR5 WT ( B ) and with IFN-gamma-pretreated 4T1-FOXL2 and 4T1 WT ( ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Aug 20, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9817_jciinsight-5-136773-g170.jpg','benchSciPubmedId':'32814714'},{'sku':'11-0041-82','imageId':'923268','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19039_nn0c03438_0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19039_nn0c03438_0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19039_nn0c03438_0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19039_nn0c03438_0003.jpg?time\u003d20240507','sortOrder':'67','description':'Figure 3 Effect of GO on spleen function, after 24 h and one month postinjection of GO at different concentrations (2.5, 5, 10 mg/mL) compared with control mice, Dex 5% (negative control), and LPS 5 mg/kg-injected (positive control) mice. (a) Blood smears stained with H \u0026 E at two magnifications, 60x (scale bar 50 mum) and inset images 300x (scale bar 5 mum). The graph represents the percentage of deviant RBCs (reticulocytes, abnormal and aged RBCs) from the total RBC counts; the black arrows indicate some of the deviant RBCs detected in LPS-injected mice. The graph was obtained after counting \u003e500 cells from each mouse ( n \u003d 3 per group). (b) Pearls\u0027 Persian blue-stained spleen tissue sections (5 mum thick) at two magnifications, 20x (scale bar, 100 mum) and inset images 100x (scale bar, 20 mum). Blue spots demonstrate regions of Persian blue-stained hemosiderin. The graph represents the percentage of total imaged tissue that stained blue, indicating the presence of hemosiderin. This was obtained by measuring the intensity of the blue-stained regions from 3 or 4 images from each mouse captured at 20x ( n \u003d 3, 4 mice per group) by Fuji Image J analysis. (c) Spleen T-lymphocyte cell counts, CD4 + T-helper cell counts plot (left), and cytotoxic CD8 + cell count plot (right). Cell counting was performed by flow cytometry. Three repeat counts were performed for each group of mice ( n \u003d 3). (d) Gene expression levels of pro-inflammatory cytokines IL-6, IL-1beta, and TNF-alpha and','shortDescription':'Figure 3 Effect of GO on spleen function, after 24 h and one month postinjection of GO at different concentrations (2.5, 5, 10 mg/mL) compared with control mice, Dex 5% (negative control), and LPS 5 mg/kg-injected (positive control) mice. (a) Blood smears stained with H \u0026 E at two magnifications, 60x (scale bar 50 mum) and inset images 300x (scale bar 5 mum). The graph represents the percentage of deviant R... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Aug 25, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'ACS nano','journalText':'ACS nano 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19039_nn0c03438_0003.jpg','benchSciPubmedId':'32658456'},{'sku':'11-0041-82','imageId':'839648','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12504_ijbsv16p2072g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12504_ijbsv16p2072g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12504_ijbsv16p2072g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12504_ijbsv16p2072g002.jpg?time\u003d20240507','sortOrder':'68','description':'Figure 2 Th1/Th2/Th17/Treg cell subset distribution in lungs of mice. The single-cell suspensions of lungs in mice were detected for Th1/Th2/Th17/Treg cell subsets by flow cytometry. (A) CD4 + IFN-gamma + Th1 cells, (B) Th1 cell percentage, (C) Absolute number of Th1 cells, (D) CD4 + IL-4 + Th2 cells, (E) Th2 cell percentage, (F) Absolute number of Th2 cells, (G) CD4 + IL-17 + Th17 cells, (H) Th17 cell percentage, (I) Absolute number of Th17 cells, (J) CD4 + CD25 + Foxp3 + Treg cells, (K) Treg cell percentage, and (L) absolute number of Treg cells each group are shown. The values are mean+-SEM of 12 mice from two independent experiments. * P \u003c 0.05, ** P \u003c 0.01, *** P \u003c 0.001.','shortDescription':'Figure 2 Th1/Th2/Th17/Treg cell subset distribution in lungs of mice. The single-cell suspensions of lungs in mice were detected for Th1/Th2/Th17/Treg cell subsets by flow cytometry. (A) CD4 + IFN-gamma + Th1 cells, (B) Th1 cell percentage, (C) Absolute number of Th1 cells, (D) CD4 + IL-4 + Th2 cells, (E) Th2 cell percentage, (F) Absolute number of Th2 cells, (G) CD4 + IL-17 + Th17 cells, (H) Th17 cell perc... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Nov 12, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of biological sciences','journalText':'International journal of biological sciences 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12504_ijbsv16p2072g002.jpg','benchSciPubmedId':'32549755'},{'sku':'11-0041-82','imageId':'923247','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_10032_ijms-21-04169-g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_10032_ijms-21-04169-g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_10032_ijms-21-04169-g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_10032_ijms-21-04169-g006.jpg?time\u003d20240507','sortOrder':'69','description':'Figure 6 Flow cytometry for immune cells in the drainage lymph nodes (DLNs). ( A ) In DLNs, the percentage of CD8 + IFNgamma + T cells was higher in 1Y-old mice than in 8W-old mice ( p \u003d 0.032; Kruskal-Wallis test followed by Dunn\u0027s post hoc test). The percentages of CD8 + IL-17A + , CD4 + IFN-gamma + , and CD4 + IL-17A + T cells in 2Y-old mice were significantly higher than in the other groups (one-way ANOVA). ( B ) The percentages of CD11b + CD86 + and CD11b + MHCII + Ly6C + cells were significantly higher in 2Y-old mice than in the other groups in the DLNs (one-way ANOVA). Red boxes indicate CD11b + MHCII + Ly6C + cells. n \u003d 15, 8, and 3 for 8W-, 1Y-, and 2Y-old mice, respectively. * p \u003c 0.05 and **** p \u003c 0.0001. Data are presented as means +- standard error.','shortDescription':'Figure 6 Flow cytometry for immune cells in the drainage lymph nodes (DLNs). ( A ) In DLNs, the percentage of CD8 + IFNgamma + T cells was higher in 1Y-old mice than in 8W-old mice ( p \u003d 0.032; Kruskal-Wallis test followed by Dunn\u0027s post hoc test). The percentages of CD8 + IL-17A + , CD4 + IFN-gamma + , and CD4 + IL-17A + T cells in 2Y-old mice were significantly higher than in the other groups (one-way ANO... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jun 11, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_10032_ijms-21-04169-g006.jpg','benchSciPubmedId':'32545199'},{'sku':'11-0041-82','imageId':'851887','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9821_jcav11p4059g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9821_jcav11p4059g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9821_jcav11p4059g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9821_jcav11p4059g006.jpg?time\u003d20240507','sortOrder':'70','description':'Figure 6 The proportion of MDSCs and M1/M2 macrophage were changed by CG-745 treatment in Hepa1-6 syngeneic mouse model: (A-C) Hepa1-6 inoculated C57BL/6 mice were treated with vehicle or 15 mg/kg/day of CG (CG-745) by intraperitoneally for 5 days/week for 3 weeks. Tumor (A, B) and spleen (C) were harvested from each individual mouse. Cells were stained with fluorescence-conjugated antibodies specific to CD3, CD4, CD8, CD25 and Foxp3, and subjected to flow cytometry analysis. The graph shows means with error bars. Error bars represent standard deviations for 3 samples in each group. Results are representative of three separate experiments (A). p \u003c 0.05.','shortDescription':'Figure 6 The proportion of MDSCs and M1/M2 macrophage were changed by CG-745 treatment in Hepa1-6 syngeneic mouse model: (A-C) Hepa1-6 inoculated C57BL/6 mice were treated with vehicle or 15 mg/kg/day of CG (CG-745) by intraperitoneally for 5 days/week for 3 weeks. Tumor (A, B) and spleen (C) were harvested from each individual mouse. Cells were stained with fluorescence-conjugated antibodies specific to CD... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 28, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of Cancer','journalText':'Journal of Cancer 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9821_jcav11p4059g006.jpg','benchSciPubmedId':'32368288'},{'sku':'11-0041-82','imageId':'839627','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12503_42003_2020_916_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12503_42003_2020_916_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12503_42003_2020_916_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12503_42003_2020_916_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'71','description':'Fig. 5 The synergistic anti-tumor effect of tankyrase and PD-1 inhibition is recapitulated by beta-catenin depletion in tumor cells and is dependent on IFNgamma and CD8 + T cells. a , B16-F10 Ctnnb1 KO tumor (s.c.) end volume reduction upon anti-PD-1 (-78%) and combined anti-PD-1/G007-LK treatment (-90%) in C57BL/6 N mice treated from day 11 through day 25. Control diet ( n \u003d 9), G007-LK diet ( n \u003d 9), anti-PD-1 ( n \u003d 10), and anti-PD-1/G007-LK ( n \u003d 10). Mann-Whitney rank sum tests are indicated by + ( P \u003c 0.05) and ++ ( P \u003c 0.01). For a - e Mean values are indicated by grey lines. b Tumor end volumes of B16-F10-challenged (s.c.) C57BL/6 Rag2 -/- mice treated for 12 days with control diet ( n \u003d 11) compared to combined anti-PD-1/G007-LK treatment ( n \u003d 10). n.s. not sig n ificant. c B16-F10 tumor (s.c.) end volume reduction upon anti-PD-1/G007-LK treatment in C57BL/6 N mice from day 10 through day 21. Control diet ( n \u003d 11), anti-IgG1 isotype control ( n \u003d 12), anti-IgG2 isotype control ( n \u003d 10), anti-CD8alpha ( n \u003d 10), anti-IFNgamma ( n \u003d 9), anti-PD-1/G007-LK ( n \u003d 10), anti-PD-1/G007-LK /anti-CD8alpha ( n \u003d 9), and anti-PD-1/G007-LK /anti-IFNgamma ( n \u003d 9). One-tailed t -tests are indicated by *( P \u003c\u003d 0.05) while one-tailed Mann-Whitney rank sum test is indicated by + ( P \u003c 0.05). d Flow cytometry analysis of CD8 + and CD4 + T cells (shown as % of CD45 + T cells) from single-cell suspensions of comparable-sized tumors collected from B16-F10-challenged (s.c.) C57BL/6 N m','shortDescription':'Fig. 5 The synergistic anti-tumor effect of tankyrase and PD-1 inhibition is recapitulated by beta-catenin depletion in tumor cells and is dependent on IFNgamma and CD8 + T cells. a , B16-F10 Ctnnb1 KO tumor (s.c.) end volume reduction upon anti-PD-1 (-78%) and combined anti-PD-1/G007-LK treatment (-90%) in C57BL/6 N mice treated from day 11 through day 25. Control diet ( n \u003d 9), G007-LK diet ( n \u003d 9), anti... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 24, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Communications biology','journalText':'Communications biology 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12503_42003_2020_916_Fig5_HTML.jpg','benchSciPubmedId':'32332858'},{'sku':'11-0041-82','imageId':'923226','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_13456_41419_2020_2489_Fig4_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_13456_41419_2020_2489_Fig4_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_13456_41419_2020_2489_Fig4_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_13456_41419_2020_2489_Fig4_HTML.jpg?time\u003d20240507','sortOrder':'72','description':'Fig. 4 Responses of the ocular surface, lacrimal gland, and DLN to desiccating injury in Fut1 KO and WT C57BL/6 mice. a Illustration of dry chamber with a fan and dehumidifier for induction of desiccation injury and experimental scheme. The 35-week-old mice were placed in a dry chamber for 10 consecutive days with intraperitoneal scopolamine injection three times a day. Ten days after injury initiation, the ocular surface, lacrimal glands, and DLN were assayed. b A circle in the photograph depicts the area of corneal opacity observed in Fut1 KO mice after desiccating injury. c Quantification of corneal stromal opacity using the standardized grading system. d The transcript levels of inflammatory cytokines in the ocular surface and intraorbital lacrimal gland as determined by real-time RT-PCR. Shown are the relative mRNA levels of each cytokine in Fut1 KO mice to the levels in WT mice. e Hematoxylin-eosin staining and CD3 immunostaining of the intraorbital lacrimal gland after injury (Scale bar, 200 mum). Neutrophil staining of the cornea with anti-neutrophil elastase Ab. Scale bars: 100 mum. f Representative and quantitative flow cytometry results for IFN-gamma + CD4 + and IL-17 + CD4 + cells in DLN from Fut1 KO and WT mice before and after desiccating stress. The percentage of CD4 + , IFN-gamma + CD4 + or IL-17 + CD4 + cells out of total DLN cells is shown, and a dot represents data from a single individual animal. Bar depicts mean +- SEM. * p \u003c 0.05, ** p \u003c 0.01, *** p \u003c 0.','shortDescription':'Fig. 4 Responses of the ocular surface, lacrimal gland, and DLN to desiccating injury in Fut1 KO and WT C57BL/6 mice. a Illustration of dry chamber with a fan and dehumidifier for induction of desiccation injury and experimental scheme. The 35-week-old mice were placed in a dry chamber for 10 consecutive days with intraperitoneal scopolamine injection three times a day. Ten days after injury initiation, the... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 24, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_13456_41419_2020_2489_Fig4_HTML.jpg','benchSciPubmedId':'32332708'},{'sku':'11-0041-82','imageId':'923205','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_13456_41419_2020_2489_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_13456_41419_2020_2489_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_13456_41419_2020_2489_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_13456_41419_2020_2489_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'73','description':'Fig. 3 Inflammatory response in the ocular surface, lacrimal glands, and ocular draining cervical lymph nodes (DLN) in Fut1 KO vs WT C57BL/6 mice. a-c Real-time RT-PCR analysis for mRNA levels of TNF-alpha, IL-1beta, and IFN-gamma in the ocular surface (cornea and conjunctiva), extraorbital and intraorbital lacrimal glands. Data are shown as the relative values of mRNA levels in Fut1 KO mice to those in WT mice. d CD3 immunostaining of extraorbital and intraorbital lacrimal glands (Scale bar, 200 mum) and neutrophil staining of the cornea (Scale bar, 100 mum). e Representative and quantitative flow cytometry results for IFN-gamma + CD4 + cells and IL-17 + CD4 + cells in DLN. The percentage of CD4 + , IFN-gamma + CD4 + or IL-17 + CD4 + cells out of total DLN cells is shown, and a dot depicts data from an individual mouse. Data are presented as mean +- SEM. * p \u003c 0.05, ** p \u003c 0.01, *** p \u003c 0.001, ns: not significant. Student\u0027s t -test (IL-1beta in a , c , e ) and Mann-Whitney U test (TNF-alpha in A, and IFN-gamma in B) were performed for statistical analysis.','shortDescription':'Fig. 3 Inflammatory response in the ocular surface, lacrimal glands, and ocular draining cervical lymph nodes (DLN) in Fut1 KO vs WT C57BL/6 mice. a-c Real-time RT-PCR analysis for mRNA levels of TNF-alpha, IL-1beta, and IFN-gamma in the ocular surface (cornea and conjunctiva), extraorbital and intraorbital lacrimal glands. Data are shown as the relative values of mRNA levels in Fut1 KO mice to those in WT ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 24, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_13456_41419_2020_2489_Fig3_HTML.jpg','benchSciPubmedId':'32332708'},{'sku':'11-0041-82','imageId':'923184','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14872_MMR-21-04-1789-g02.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14872_MMR-21-04-1789-g02.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14872_MMR-21-04-1789-g02.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14872_MMR-21-04-1789-g02.jpg?time\u003d20240507','sortOrder':'74','description':'Figure 3. Expansion of the CD4 + CD25 + T-cell population is driven by combined treatment with PD-L1 Ig and anti-CD40L mAbs in the CBA/J x DBA/2 model. (A) Number of CD4 + CD25 + T cells in splenocytes was determined by flow cytometry. (B) Gating strategy used for flow cytometry, using the FSC/SSC method. R1 represents the T lymphocyte population. (C) Percentage of CD4 + CD25 + T cells. ***P\u003c0.001 vs. the normal group (CBA/J x BALB/c). ### P\u003c0.001 vs. the spontaneous abortion group (CBA/J x DBA/2); \u0026\u0026\u0026 P\u003c0.001 vs. PD-L1 Ig + CD40L mAb group. PD-L1, programmed death-ligand 1; Ig, immunoglobulin; CD40L, CD40 ligand; mAb, monoclonal antibody; FSC, forward scatter; SSC, side scatter; PE, phycoerythrin.','shortDescription':'Figure 3. Expansion of the CD4 + CD25 + T-cell population is driven by combined treatment with PD-L1 Ig and anti-CD40L mAbs in the CBA/J x DBA/2 model. (A) Number of CD4 + CD25 + T cells in splenocytes was determined by flow cytometry. (B) Gating strategy used for flow cytometry, using the FSC/SSC method. R1 represents the T lymphocyte population. (C) Percentage of CD4 + CD25 + T cells. ***P\u003c0.001 vs. the n... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular medicine reports','journalText':'Molecular medicine reports 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14872_MMR-21-04-1789-g02.jpg','benchSciPubmedId':'32319625'},{'sku':'11-0041-82','imageId':'838999','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12427_ADVS-7-1903301-g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12427_ADVS-7-1903301-g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12427_ADVS-7-1903301-g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12427_ADVS-7-1903301-g005.jpg?time\u003d20240507','sortOrder':'75','description':'Figure 5 Immune stimulation ability and therapeutic efficacy of mini DC in tumor-bearing mice. A) Schematic diagram for the therapeutic regimen of mini DC in tumor-bearing mice. The mice inoculated with ID8 mouse ovarian cancer cells subcutaneous (s.c.) received six doses of various vaccine formulations, and tumor growth was measured over time ( n \u003d 5 biologically independent animals in each group). B) Average and C) individual tumor growth curves as well as D) the digital tumor mass images of tumor-bearing mice treated with indicated vaccine regimens. When the tumor area of the control group exceeds 200 mm 2 , mice were sacrificed, and tumors and spleens were collected for section and analysis of the immune cell profile. E) Representative immunofluorescence staining images of tumor sections from different groups. Green represents CD3 and red represents CD8. Scale bar: 50 um. F) Representative flow cytometry contour plots of CD8 + CD3 + T eff and G) Foxp3 + CD4 + T reg in the spleens of tumor-bearing mice at the end of the study. Data in panel (B) show mean +- SD and were analyzed by two-way ANOVA with Tukey\u0027\u0027s multiple comparisons test. **** p \u003c 0.0001 and ** p \u003c 0.01.','shortDescription':'Figure 5 Immune stimulation ability and therapeutic efficacy of mini DC in tumor-bearing mice. A) Schematic diagram for the therapeutic regimen of mini DC in tumor-bearing mice. The mice inoculated with ID8 mouse ovarian cancer cells subcutaneous (s.c.) received six doses of various vaccine formulations, and tumor growth was measured over time ( n \u003d 5 biologically independent animals in each group). B) Aver... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Advanced science (Weinheim, Baden-Wurttemberg, Germany)','journalText':'Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12427_ADVS-7-1903301-g005.jpg','benchSciPubmedId':'32274314'},{'sku':'11-0041-82','imageId':'838940','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12427_ADVS-7-1903301-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12427_ADVS-7-1903301-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12427_ADVS-7-1903301-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12427_ADVS-7-1903301-g004.jpg?time\u003d20240507','sortOrder':'76','description':'Figure 4 In vivo activation of T cells by mini DC. A) Representative flow cytometry scatter plots and D) frequency of CD3 + CD8 + T cells in dLNs of mice 3 days after immunization with six dosages of PBS, ID8 lysate, PLGA-NP, BMDC, or mini DC ( n \u003d 5 biologically independent animals in each group). Flow cytometry analysis and percentage of B,E) IFN-gamma + CD8 + effector T cells and C,F) Foxp3 + CD25 + CD4 + regulatory T cells isolated from spleens of mice receiving different vaccinations. G) IFN-gamma and H) TNF-alpha levels in serum of immunized mice measured by ELISA. I) Ex vivo cytotoxicity of CD8 + T cells isolated from spleens of immunized mice 3 days after vaccination with different vaccine formulations ( n \u003d 4). CD8 + T cells (effector cell) and ID8 cells (target cell) were cocultured at ratios of 20:1 and 10:1 (E:T) for 10 h. In panels (D)-(I), representative data were expressed as mean +- SD. One-way ANOVA with Dunnett\u0027\u0027s posthoc analysis was used to calculate statistical significance. **** p \u003c 0.0001, *** p \u003c 0.001, ** p \u003c 0.01, and * p \u003c 0.05. NS: no significance.','shortDescription':'Figure 4 In vivo activation of T cells by mini DC. A) Representative flow cytometry scatter plots and D) frequency of CD3 + CD8 + T cells in dLNs of mice 3 days after immunization with six dosages of PBS, ID8 lysate, PLGA-NP, BMDC, or mini DC ( n \u003d 5 biologically independent animals in each group). Flow cytometry analysis and percentage of B,E) IFN-gamma + CD8 + effector T cells and C,F) Foxp3 + CD25 + CD4 ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Advanced science (Weinheim, Baden-Wurttemberg, Germany)','journalText':'Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12427_ADVS-7-1903301-g004.jpg','benchSciPubmedId':'32274314'},{'sku':'11-0041-82','imageId':'923163','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14871_41541_2019_143_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14871_41541_2019_143_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14871_41541_2019_143_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14871_41541_2019_143_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'77','description':'Fig. 3 ZIKV NS4B-C100S induces potent antiviral adaptive immune responses. a - c Six-week-old AB6 ( a ) or WT B6 ( b ) were infected with 2 x 10 4 FFU WT FSS13025ic (WT) and ZIKV NS4B-C100S (C100S). a On day 28, splenocytes of AB6 mice were cultured ex vivo with WT ZIKV for 24 h and were stained for IFN-gamma, CD3, and CD4 or CD8. Total number of T-cell subsets per spleen. b Supernatants from the ex vivo culture were collected on day 2 after WT ZIKV re-stimulation and measured for Th1-cytokine production. c On day 28 after immunization, sera collected from AB6 or B6 mice were measured for NAb titers. Data are presented as means +- SEM, n \u003d 3-7 and are representative of two to three similar experiments. ** P \u003c 0.01 or * P \u003c 0.05 compared with WT group (unpaired t -test).','shortDescription':'Fig. 3 ZIKV NS4B-C100S induces potent antiviral adaptive immune responses. a - c Six-week-old AB6 ( a ) or WT B6 ( b ) were infected with 2 x 10 4 FFU WT FSS13025ic (WT) and ZIKV NS4B-C100S (C100S). a On day 28, splenocytes of AB6 mice were cultured ex vivo with WT ZIKV for 24 h and were stained for IFN-gamma, CD3, and CD4 or CD8. Total number of T-cell subsets per spleen. b Supernatants from the ex vivo cu... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Oct 1, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'NPJ vaccines','journalText':'NPJ vaccines 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14871_41541_2019_143_Fig3_HTML.jpg','benchSciPubmedId':'31815005'},{'sku':'11-0041-82','imageId':'735286','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_7553_JCMM-24-1684-g007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_7553_JCMM-24-1684-g007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_7553_JCMM-24-1684-g007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_7553_JCMM-24-1684-g007.jpg?time\u003d20240507','sortOrder':'78','description':'Figure 7 MSC-TGF-beta1 increased the proportion of Foxp3 + Treg cells. Mononuclear cells were extracted from mice blood and analysed on day 21 post-transplant by flow cytometry on the proportion of Foxp3 + Treg cells. A, Proportion of Foxp3 + Treg cells in CD4 + T cells. B, Quantitative analysis of the proportion of Foxp3 + Treg cells. Data are representative of three independent experiments with 5-7 mice per group. Data are presented as the mean +- SD. * P \u003c .05, ** P \u003c .01, *** P \u003c .001','shortDescription':'Figure 7 MSC-TGF-beta1 increased the proportion of Foxp3 + Treg cells. Mononuclear cells were extracted from mice blood and analysed on day 21 post-transplant by flow cytometry on the proportion of Foxp3 + Treg cells. A, Proportion of Foxp3 + Treg cells in CD4 + T cells. B, Quantitative analysis of the proportion of Foxp3 + Treg cells. Data are representative of three independent experiments with 5-7... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of cellular and molecular medicine','journalText':'Journal of cellular and molecular medicine 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_7553_JCMM-24-1684-g007.jpg','benchSciPubmedId':'31782262'},{'sku':'11-0041-82','imageId':'735282','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8134_10.1177_2040622319860653-fig4.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8134_10.1177_2040622319860653-fig4.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8134_10.1177_2040622319860653-fig4.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8134_10.1177_2040622319860653-fig4.jpg?time\u003d20240507','sortOrder':'79','description':'Figure 4. LGG administration protected against osteoclastogenesis and modulated theimmune response in the BM. (a) Representative images of bone marrow stained by TRAP in the femur(yellow arrows indicate claret-red osteoclast stained by TRAP). Scalebar \u003d 100 mum. ELISA analysis of cell supernatant levels of RANKL (b),TNF-alpha (c), and IL-17 (d) ( n \u003d 10 mice per group). (e)FACS analysis on the ratios of Treg and Th17 cells in CD4 + Tcell subset and the Treg:Th17 cell ratio from the BM( n \u003d 6 mice per group). (f) Representative FACS plotsof the ratio of Treg cells in CD4 + T cell subset of the BM.(g) Representative FACS plots of the ratio of Th17 cells in theCD4 + T cell subset of the BM. Data are expressed as mean+- SD. All data were normally distributed according to the Shapiro-Wilknormality test and analyzed using two-way ANOVA and posthoc tests applying the LSD correction for multiplecomparisons. * p \u003c 0.05 compared with the Shamgroup. # p \u003c 0.05 compared with the LGG+TDFgroup. % p \u003c 0.05 compared with the E.coli +TDF group. $ p \u003c 0.05 compared with the TDF group. ANOVA, analysis of variance; BM, bone marrow; ELISA, enzyme-linkedimmunosorbent assay; FACS, fluorescence-activated cell sorting; IL-17,interleukin-17; LGG, Lactobacillus rhamnosus GG; LSD,least significant difference; RANKL, receptor activator of nuclearfactor kappa-B ligand; SD, standard deviation; TDF, tenofovir disoproxilfumarate; Th17, T-helper 17 cell; TNF-alpha, tumor necrosis factor alpha;TR','shortDescription':'Figure 4. LGG administration protected against osteoclastogenesis and modulated theimmune response in the BM. (a) Representative images of bone marrow stained by TRAP in the femur(yellow arrows indicate claret-red osteoclast stained by TRAP). Scalebar \u003d 100 mum. ELISA analysis of cell supernatant levels of RANKL (b),TNF-alpha (c), and IL-17 (d) ( n \u003d 10 mice per group). (e)FACS analysis on the ratios of Tr... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 9, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Therapeutic advances in chronic disease','journalText':'Therapeutic advances in chronic disease 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8134_10.1177_2040622319860653-fig4.jpg','benchSciPubmedId':'31321013'},{'sku':'11-0041-82','imageId':'735283','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8134_10.1177_2040622319860653-fig6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8134_10.1177_2040622319860653-fig6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8134_10.1177_2040622319860653-fig6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8134_10.1177_2040622319860653-fig6.jpg?time\u003d20240507','sortOrder':'80','description':'Figure 6. LGG regulated the intestinal inflammatory response and permeability. (a) FACS analysis of Treg and Th17 cells in MLNs ( n \u003d 6mice per group). (b) Representative FACS plots of ratio of Treg cells inthe CD4 + T cell subset of MLNs. (c) Representative FACS plotsof the ratio of Th17 cells in the CD4 + T cell subset of MLNs.(d) qPCR analysis measuring the transcript levels of the claudin family( n \u003d 6 mice per group). (e) ELISA analysis of serumlevels of ET ( n \u003d 8-10 mice per group). (f) Serum FD4levels were measured in serum ( n \u003d 9-10 mice pergroup). Data are expressed as mean +- SD. All data were normallydistributed according to the Shapiro-Wilk normality test and analyzedusing two-way ANOVA and post hoc tests applying the LSDcorrection for multiple comparisons. * p \u003c 0.05 compared with the Shamgroup. # p \u003c 0.05 compared with the LGG+TDFgroup. % p \u003c 0.05 compared with the E.coli +TDF group. $ p \u003c 0.05 compared with the TDF group. ANOVA, analysis of variance; ELISA, enzyme-linked immunosorbent assay;ET, endotoxin; FD4, fluorescently labeled dextran; LGG, Lactobacillus rhamnosus GG; LSD, least significantdifference; MLNs, mesenteric lymph nodes; qPCR, quantitative real-timepolymerase chain reaction; TDF, tenofovir disoproxil fumarate; Th17,T-helper 17 cell; Treg, regulatory T cell; ZOL, zoledronic acid.','shortDescription':'Figure 6. LGG regulated the intestinal inflammatory response and permeability. (a) FACS analysis of Treg and Th17 cells in MLNs ( n \u003d 6mice per group). (b) Representative FACS plots of ratio of Treg cells inthe CD4 + T cell subset of MLNs. (c) Representative FACS plotsof the ratio of Th17 cells in the CD4 + T cell subset of MLNs.(d) qPCR analysis measuring the transcript levels of the claudin family( n ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 9, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Therapeutic advances in chronic disease','journalText':'Therapeutic advances in chronic disease 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8134_10.1177_2040622319860653-fig6.jpg','benchSciPubmedId':'31321013'},{'sku':'11-0041-82','imageId':'923121','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14869_JCMM-23-5588-g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14869_JCMM-23-5588-g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14869_JCMM-23-5588-g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14869_JCMM-23-5588-g006.jpg?time\u003d20240507','sortOrder':'81','description':'Figure 6 Bryostatin-1 treated Il-10 -/- mice show lower Th1 and Th17 responses than the untreated Il-10 -/- mice. Intracellular cytokine staining and flow cytometric analysis demonstrated a significant decrease in the proportion of IFN-gamma + CD4 + T cells in Bry-1-treated mice compared with untreated Il-10 -/- mice in the spleen (A and B) and MLN (C and D); however, these proportions were still higher than those in WT mice. (E and F) A significant decrease in the proportion of IL-17A + CD4 + T cells was observed in Bry-1-treated mice compared with untreated Il-10 -/- mice in both the spleen (E and F) and MLN (G and H), but these T lymphocyte proportions were still higher than those in WT mice. Bry-1, Bryostatin-1; WT, wild-type; MLN, mesenteric lymph nodes; and NS, no significance. At least three independent experiments with six to eight mice in each group were performed, with one representative experiment is shown. The data are expressed as the mean +- SD. V P \u003c 0.05','shortDescription':'Figure 6 Bryostatin-1 treated Il-10 -/- mice show lower Th1 and Th17 responses than the untreated Il-10 -/- mice. Intracellular cytokine staining and flow cytometric analysis demonstrated a significant decrease in the proportion of IFN-gamma + CD4 + T cells in Bry-1-treated mice compared with untreated Il-10 -/- mice in the spleen (A and B) and MLN (C and D); however, these proportions were still... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of cellular and molecular medicine','journalText':'Journal of cellular and molecular medicine 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14869_JCMM-23-5588-g006.jpg','benchSciPubmedId':'31251471'},{'sku':'11-0041-82','imageId':'735281','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_7860_fgene-10-00545-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_7860_fgene-10-00545-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_7860_fgene-10-00545-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_7860_fgene-10-00545-g001.jpg?time\u003d20240507','sortOrder':'82','description':'FIGURE 1 Ovalbumin (OVA)-induced acute model of asthma. (A) Pulmonary inflammatory response was increased in the mice challenged with OVA, bar \u003d 20 mum. (B) The airway hyperresponse was elevated in the mice from the asthma group, * p \u003c 0.05 (C) . Sera IgE was significantly increased in the mice from the asthma group, * p \u003c 0.05. (D) CD4 + T cells magnificently sorted from the spleen were validated by flow cytometry. Representative results of two independent experiments with five mice in each group, ** p \u003c 0.01, *** p \u003c 0.01, **** p \u003c 0.0001.','shortDescription':'FIGURE 1 Ovalbumin (OVA)-induced acute model of asthma. (A) Pulmonary inflammatory response was increased in the mice challenged with OVA, bar \u003d 20 mum. (B) The airway hyperresponse was elevated in the mice from the asthma group, * p \u003c 0.05 (C) . Sera IgE was significantly increased in the mice from the asthma group, * p \u003c 0.05. (D) CD4 + T cells magnificently sorted from the spleen were validat... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Apr 8, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in genetics','journalText':'Frontiers in genetics 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_7860_fgene-10-00545-g001.jpg','benchSciPubmedId':'31231429'},{'sku':'11-0041-82','imageId':'923100','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5889_gr5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5889_gr5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5889_gr5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5889_gr5.jpg?time\u003d20240507','sortOrder':'83','description':'Figure 5 Immunomodulatory Profile and Functions of TAM-EVs (A and B) Gene set enrichment analysis (GSEA) plots showing the correlation of TAM (TAM-Cell) and TAM-EV protein signatures with genes expressed in FACS-sorted M1-like or M2-like TAMs (A) or prognostic genes across human cancers recorded in the PRECOG database (B). (C) Flow cytometry analysis of CD8 + T cells obtained after priming OT-I splenocytes. (D) Schematic of the experiment shown in (E-G). (E and F) Flow cytometry analysis of CD8 + OT-I proliferation assessed by CellTrace dilution. (E) Representative flow profiles. (F) Quantification of the data (mean +- SEM; n \u003d 4 cell cultures/condition). Statistics by two-way ANOVA, using Sidak\u0027s multiple comparison test. (G) ELISA-based quantification of IFNgamma in medium conditioned by OT-I CD8 + T cells. Data are shown as mean +- SEM (n \u003d 4 cell cultures/condition). Statistics as in (F). (H) Flow cytometry analysis of CD8 + T cells purified from the spleen of C57BL/6 mice. (I) Schematic of the experiment shown in (J and K). (J) Flow cytometry analysis of CD8 + T cell proliferation assessed by CellTrace dilution (mean +- SEM; n \u003d 4 cell cultures/condition). Statistics by one-way ANOVA, using Tukey\u0027s multiple comparison test. (K) ELISA-based quantification of IFNgamma in medium conditioned by CD8 + T cells (mean +- SEM; n \u003d 4 cell cultures/condition). Statistics as in (J). (L) Flow cytometry analysis of CD4 + T cells purified from the spleen of BALB/c mice. (M) Schematic o','shortDescription':'Figure 5 Immunomodulatory Profile and Functions of TAM-EVs (A and B) Gene set enrichment analysis (GSEA) plots showing the correlation of TAM (TAM-Cell) and TAM-EV protein signatures with genes expressed in FACS-sorted M1-like or M2-like TAMs (A) or prognostic genes across human cancers recorded in the PRECOG database (B). (C) Flow cytometry analysis of CD8 + T cells obtained after priming OT-I splenocytes.... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jun 4, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell reports','journalText':'Cell reports 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5889_gr5.jpg','benchSciPubmedId':'31167148'},{'sku':'11-0041-82','imageId':'850570','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8325_nihms-1528318-f0009.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8325_nihms-1528318-f0009.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8325_nihms-1528318-f0009.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8325_nihms-1528318-f0009.jpg?time\u003d20240507','sortOrder':'84','description':'Extended Data Figure 5: Nonconditioned transplantation into immunodeficient recipients (a) Schematic of nonconditioned allogeneic transplantation: 100 CD150 + CD34 - KSL cells from C57BL/6-CD45.2 mice were expanded for 28-days before being transplanted into non-conditioned immunodeficient NOD/SCID recipients. (b) 4-week donor PB chimerism of 100 fresh HSCs (n\u003d5) or a 28-day HSC culture derived from 100 HSCs (n\u003d5), transplanted as described in ( a ). Each column represents an individual mouse. N.D. denotes not detected. (c) Example flow cytometric plots displaying T cell (CD4/CD8) and B cell (CD45RA, also known as B220) PB lineages within non-conditioned NOD/SCID mice at 16-weeks post-transplantation (representative of 5 mice), as described in ( a ).','shortDescription':'Extended Data Figure 5: Nonconditioned transplantation into immunodeficient recipients (a) Schematic of nonconditioned allogeneic transplantation: 100 CD150 + CD34 - KSL cells from C57BL/6-CD45.2 mice were expanded for 28-days before being transplanted into non-conditioned immunodeficient NOD/SCID recipients. (b) 4-week donor PB chimerism of 100 fresh HSCs (n\u003d5) or a 28-day HSC culture derived from 100 HSCs... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jul 1, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature','journalText':'Nature 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8325_nihms-1528318-f0009.jpg','benchSciPubmedId':'31142833'},{'sku':'11-0041-82','imageId':'923058','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14867_ADVS-6-1802042-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14867_ADVS-6-1802042-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14867_ADVS-6-1802042-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14867_ADVS-6-1802042-g004.jpg?time\u003d20240507','sortOrder':'85','description':'Figure 4 SMU-Z1 increases splenocyte proliferation, CD8 + /CD4 + ratio, and TLR2 expression. A) SMU-Z1 treatment accelerated splenocyte proliferation at different concentrations. B) Time kinetics of SMU-Z1 stimulated primary splenocyte proliferation at 5 x 10 -6 m . Cell proliferation was tested by measuring CCK8 absorbance at 450 nm at different time intervals. C) Percentages of CD19 + B cells present within splenocytes were determined by flow cytometry at various time points after treatment with PBS, 5 ug Pam 3 CSK 4 (Pam3), or 0.1 mg of SMU-Z1 in C57BL/6 mice. D) Representative graphs of CD4 + and CD8 + T cells from PBS, Pam 3 CSK 4 (Pam3), or SMU-Z1-treated mice. The percentage of CD8 + and ratio of CD8 + /CD4 + T cells increased after treatment with SMU-Z1. E) Percentage of TLR2 positive cells (CD3 + CD8 + TLR2 + ) in the spleen. Results shown are average values from three independent experiments, and the data are presented as mean +- SD. *, p \u003c 0.01; **, p \u003c 0.001 compared to the control group.','shortDescription':'Figure 4 SMU-Z1 increases splenocyte proliferation, CD8 + /CD4 + ratio, and TLR2 expression. A) SMU-Z1 treatment accelerated splenocyte proliferation at different concentrations. B) Time kinetics of SMU-Z1 stimulated primary splenocyte proliferation at 5 x 10 -6 m . Cell proliferation was tested by measuring CCK8 absorbance at 450 nm at different time intervals. C) Percentages of CD19 + B cells present with... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'May 17, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Advanced science (Weinheim, Baden-Wurttemberg, Germany)','journalText':'Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14867_ADVS-6-1802042-g004.jpg','benchSciPubmedId':'31131189'},{'sku':'11-0041-82','imageId':'923142','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14870_acd-30-909-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14870_acd-30-909-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14870_acd-30-909-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14870_acd-30-909-g002.jpg?time\u003d20240507','sortOrder':'86','description':'Fig. 2 CS2164 affects the frequencies of T-cell subpopulations in the spleen. The frequencies of CD4 + and CD8 + T cells (a) and CD25 + Foxp3 + Tregs (b) in the spleen from vehicle-treated or CS2164-treated mice described in Fig. 1 were analyzed by flow cytometry. The representative plots are shown and the accumulative data are expressed as mean +- SD from one of two independent experiments. ** P \u003c 0.01 compared with the vehicle control group.','shortDescription':'Fig. 2 CS2164 affects the frequencies of T-cell subpopulations in the spleen. The frequencies of CD4 + and CD8 + T cells (a) and CD25 + Foxp3 + Tregs (b) in the spleen from vehicle-treated or CS2164-treated mice described in Fig. 1 were analyzed by flow cytometry. The representative plots are shown and the accumulative data are expressed as mean +- SD from one of two independent experiments. ** P \u003c 0... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Oct 1, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Anti-cancer drugs','journalText':'Anti-cancer drugs 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14870_acd-30-909-g002.jpg','benchSciPubmedId':'30998512'},{'sku':'11-0041-82','imageId':'735280','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8142_MI2019-4652596.005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8142_MI2019-4652596.005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8142_MI2019-4652596.005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8142_MI2019-4652596.005.jpg?time\u003d20240507','sortOrder':'87','description':'Figure 5 (a) BMDCs were transfected with LV-IL10-GFP or LV-mock-GFP to acquire DC-IL10 and DC-mock cells, respectively. Mice were randomly divided into G1 (control group), G2 (model group), G3 (DC-mock-treated group), and G4 (DC-IL10-treated group). Liver fibrosis (G2, G3, and G4) was induced by twice a week intraperitoneal injection of 40% CCl4 as a 2 : 3 mixture with olive oil for 8 weeks. The control group was administered with the same volume of olive oil only, twice a week for 8 weeks. In the 6th week of CCl4 injection, the mice in the G3 and G4 groups were treated with DC-mock or DC-IL10 (1 x 10 6 /0.2 ml) suspended in RPMI 1640 into the tail vein (twice a week for 2 weeks) till the 8th week, while the control group and model group received equivalent volumes of RPMI 1640 tail vein injection instead of DC treatment. All mice were sacrificed 72 h following the final CCl4 or olive oil injection at the 8th week. Splenocytes were isolated from the spleen in each group of mice to analyze the immune-regulatory effect of DC-IL10 on Th17 cells. The lymphocytes were stimulated for 5 h with PMA and BFA in RPMI 1640 containing 10% FBS and then stained with anti-CD4-FITC. They were fixed and permeabilized with Fix/PERM kit and stained intracellularly with anti-IL-17-PE. The percentages of Th17 cells were determined by flow cytometry. Cells stained with IgG isotype control were used as controls. (b) DC-IL10 suppresses the generation of Th17 cells. The percentages of Th17 cells in','shortDescription':'Figure 5 (a) BMDCs were transfected with LV-IL10-GFP or LV-mock-GFP to acquire DC-IL10 and DC-mock cells, respectively. Mice were randomly divided into G1 (control group), G2 (model group), G3 (DC-mock-treated group), and G4 (DC-IL10-treated group). Liver fibrosis (G2, G3, and G4) was induced by twice a week intraperitoneal injection of 40% CCl4 as a 2 : 3 mixture with olive oil for 8 weeks. The control g... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jun 11, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Mediators of inflammation','journalText':'Mediators of inflammation 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8142_MI2019-4652596.005.jpg','benchSciPubmedId':'30800002'},{'sku':'11-0041-82','imageId':'922995','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14826_41598_2018_37175_Fig9_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14826_41598_2018_37175_Fig9_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14826_41598_2018_37175_Fig9_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14826_41598_2018_37175_Fig9_HTML.jpg?time\u003d20240507','sortOrder':'88','description':'Figure 9 Representative gating strategies used to analyze cell types by flow cytometry. Shown are representative dot plots with gating for CD4+/CD62L+ and CD8+/CD62L+ T-cells ( a ), T-regulatory Cells (CD4+/CD25+/FOXP3+) ( b ), CD4+ Memory T-cells (CD4+/CD44+/CD62L+) and CD8+ Memory T-cells (CD8+/CD44+/CD62L+) ( c ), and CCR7+/CD4+ Memory T-cells and CCR7+/CD8+ Memory T-cells ( d ).','shortDescription':'Figure 9 Representative gating strategies used to analyze cell types by flow cytometry. Shown are representative dot plots with gating for CD4+/CD62L+ and CD8+/CD62L+ T-cells ( a ), T-regulatory Cells (CD4+/CD25+/FOXP3+) ( b ), CD4+ Memory T-cells (CD4+/CD44+/CD62L+) and CD8+ Memory T-cells (CD8+/CD44+/CD62L+) ( c ), and CCR7+/CD4+ Memory T-cells and CCR7+/CD8+ Memory T-cells ( d ).','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jan 30, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Scientific reports','journalText':'Scientific reports 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14826_41598_2018_37175_Fig9_HTML.jpg','benchSciPubmedId':'30700819'},{'sku':'11-0041-82','imageId':'923016','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14866_biolopen-8-036244-g5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14866_biolopen-8-036244-g5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14866_biolopen-8-036244-g5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14866_biolopen-8-036244-g5.jpg?time\u003d20240507','sortOrder':'89','description':'Fig. 5. Enhanced Th2 cytokine responses in the draining lymph nodes following challenge with OVA. Ten IL-31RA KO mice were sensitized intraperitoneally with 100 ug OVA in the presence of aluminum hydroxide at days 0, 7 and 14, and an intranasal challenge with 5% OVA started on day 21 for 7 consecutive days. (A) Lungs were collected for detection of Th2 and Th17 infiltrates by immunohistochemistry ( n \u003d6). (B) CD4 + T cells and (C) Th1, Th2, Th9 and Th17 populations in peripheral blood were analyzed by flow cytometry ( n \u003d5-10). (D) Draining lymph node cells from OVA-challenged mice were stimulated with 20 mug/ml of OVA for 48 h. Levels of IFN-gamma, IL-4, IL-13 and IL-17 in supernatants detected by ELISA ( n \u003d5-6). Data expressed as the mean+-s.e.m. Significance was determined by two-tailed Student\u0027s t -test. The experiment was repeated twice.','shortDescription':'Fig. 5. Enhanced Th2 cytokine responses in the draining lymph nodes following challenge with OVA. Ten IL-31RA KO mice were sensitized intraperitoneally with 100 ug OVA in the presence of aluminum hydroxide at days 0, 7 and 14, and an intranasal challenge with 5% OVA started on day 21 for 7 consecutive days. (A) Lungs were collected for detection of Th2 and Th17 infiltrates by immunohistochemistry ( n \u003d6). (... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jan 15, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Biology open','journalText':'Biology open 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14866_biolopen-8-036244-g5.jpg','benchSciPubmedId':'30647024'},{'sku':'11-0041-82','imageId':'923037','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14866_biolopen-8-036244-g6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14866_biolopen-8-036244-g6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14866_biolopen-8-036244-g6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14866_biolopen-8-036244-g6.jpg?time\u003d20240507','sortOrder':'90','description':'Fig. 6. IL-31R signaling suppressed the proliferation of CD4 + T cells. Purified CD4 + T cells from WT and IL-31RA KO mice were stimulated with anti-CD3/anti-CD28. The activation ( n \u003d4) (A) and proliferation ( n \u003d4) (B) of CD4 + T cells were assayed by flow cytometry. All values are plotted and lines indicate means. Statistical significance was determined by two-tailed Student\u0027s t - tests. The experiment was repeated twice. Ctrl, control; Act, activation.','shortDescription':'Fig. 6. IL-31R signaling suppressed the proliferation of CD4 + T cells. Purified CD4 + T cells from WT and IL-31RA KO mice were stimulated with anti-CD3/anti-CD28. The activation ( n \u003d4) (A) and proliferation ( n \u003d4) (B) of CD4 + T cells were assayed by flow cytometry. All values are plotted and lines indicate means. Statistical significance was determined by two-tailed Student\u0027s t - tests. The experiment w... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jan 15, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Biology open','journalText':'Biology open 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14866_biolopen-8-036244-g6.jpg','benchSciPubmedId':'30647024'},{'sku':'11-0041-82','imageId':'519420','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5004_elife-37851-fig1.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5004_elife-37851-fig1.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5004_elife-37851-fig1.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5004_elife-37851-fig1.jpg?time\u003d20240507','sortOrder':'91','description':'Figure 1. Dual-color Bcl11b reporter strategy can reveal epigenetic mechanisms controlling T-cell lineage commitment. ( A ) Overview of early T-cell development. Bcl11b turns on to silence alternate fate potentials and drive T-cell fate commitment. ETP - early thymic progenitor; DN2 - CD4 - CD8 - double negative-2A progenitor; DP - CD4 + CD8 + ; NK - natural killer; DC - dendritic cell. ( B ) Dual-allelic Bcl11b reporter cells, where two distinguishable fluorescent proteins (YFP and mCherry) are inserted non-disruptively into the same sites on the two endogenous Bcl11b loci. ( C ) Flow cytometry plots show cKit versus CD25 levels in CD4 - CD8 - double negative (DN) thymic progenitors (left), along with Bcl11b-YFP versus Bcl11b-mCh expression levels in the indicated DN progenitor subsets from dual Bcl11b reporter mice. Arrowheads indicate cells expressing one copy of Bcl11b . ( D ) Flow plots show Bcl11b-YFP versus Bcl11b-mCh levels in CD4 + CD8 + double positive (DP) T-cell precursors from the thymus (left), or CD4 (center) or CD8 (right) T-cells from the spleen. Results are representative of analysis of 6-8 mice from two independent experiments. See also Figure 1--figure supplement 1 . Figure 1--figure supplement 1. Experimental strategy for generating different Bcl11b reporter mouse strains. The two Bcl11b loci were targeted in embryonic stem (ES) cells using homologous recombination, followed by drug selection using the indicated drug-res','shortDescription':'Figure 1. Dual-color Bcl11b reporter strategy can reveal epigenetic mechanisms controlling T-cell lineage commitment. ( A ) Overview of early T-cell development. Bcl11b turns on to silence alternate fate potentials and drive T-cell fate commitment. ETP - early thymic progenitor; DN2 - CD4 - CD8 - double negative-2A progenitor; DP - CD4 + CD8 + ; NK - natural killer; DC - dendritic cell. ( B ) Dual-... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Nov 20, 2018, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5004_elife-37851-fig1.jpg','benchSciPubmedId':'30457103'},{'sku':'11-0041-82','imageId':'519421','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5004_elife-37851-fig3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5004_elife-37851-fig3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5004_elife-37851-fig3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5004_elife-37851-fig3.jpg?time\u003d20240507','sortOrder':'92','description':'Figure 3. A distal enhancer region controls Bcl11b activation probability. ( A ) Schematic of normal and enhancer-deleted two-color Bcl11b reporter strains (left). Genome browser plots (right), showing +850 kb enhancer of Bcl11b, showing distributions of histone marks (H3K4me2, H3K27me3, and H3K27Ac) and an associated LncRNA ( Isoda et al., 2017 ). Orientation is with transcription from left to right (reversed relative to genome numbering). Gray shaded area indicates the enhancer region deleted using gene targeting (removed region: chr12:108,396,825-108,398,672, mm9). ( B ) Flow cytometry plots show Bcl11b-mCh versus Bcl11b-YFP levels in developing T-cell populations from dual Bcl11b reporter mice, either with an intact YFP enhancer (top), or a disrupted YFP enhancer (bottom). Results are representative of two independent experiments. ( C ) Bar graphs showing the percentages of cells in early thymic populations with mono- and bi-allelic expression of wildtype mCherry and wildtype YFP versus mutant YFP alleles in wildtype Bcl11b YFP/mCh and Bcl11b YFPDeltaEnh/mCh dual reporter mice, demonstrating the reduced frequency of mutant YFP allele expression relative to the wildtype mCherry allele in the same cells. Each bar shows results from one mouse; n \u003d 4 mice of each strain are shown. ( D ) DN2 progenitors were sorted for different Bcl11b allelic activation states as indicated, cultured on OP9-DL1 monolayers for 4 days, and analyzed using flow cytometry. Flow','shortDescription':'Figure 3. A distal enhancer region controls Bcl11b activation probability. ( A ) Schematic of normal and enhancer-deleted two-color Bcl11b reporter strains (left). Genome browser plots (right), showing +850 kb enhancer of Bcl11b, showing distributions of histone marks (H3K4me2, H3K27me3, and H3K27Ac) and an associated LncRNA ( Isoda et al., 2017 ). Orientation is with transcription from left to rig... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Nov 20, 2018, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5004_elife-37851-fig3.jpg','benchSciPubmedId':'30457103'},{'sku':'11-0041-82','imageId':'519422','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5004_elife-37851-fig3-figsupp4.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5004_elife-37851-fig3-figsupp4.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5004_elife-37851-fig3-figsupp4.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5004_elife-37851-fig3-figsupp4.jpg?time\u003d20240507','sortOrder':'93','description':'Figure 3--figure supplement 4. Thymocytes from homozygous mutant enhancer Bcl11b YFPDeltaEnh/YFPDeltaEnh mice are able to generate T-cell subsets expressing Bcl11b at normal levels relative to wild-type enhancer Bcl11b YFP/YFP mice. Representative FACS plots showing gates used for CD4 and CD8 double negative (DN), double positive (DP) and single positive (CD4 and CD8) populations (left plots) and the relative levels of Bcl11b-YFP in each subset generated from enhancer mutant and wild-type mice (right histograms, n \u003d 2 for each genotype).','shortDescription':'Figure 3--figure supplement 4. Thymocytes from homozygous mutant enhancer Bcl11b YFPDeltaEnh/YFPDeltaEnh mice are able to generate T-cell subsets expressing Bcl11b at normal levels relative to wild-type enhancer Bcl11b YFP/YFP mice. Representative FACS plots showing gates used for CD4 and CD8 double negative (DN), double positive (DP) and single positive (CD4 and CD8) populations (left plots) and the re... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Nov 20, 2018, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5004_elife-37851-fig3-figsupp4.jpg','benchSciPubmedId':'30457103'},{'sku':'11-0041-82','imageId':'922974','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14865_13046_2018_929_Fig6_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14865_13046_2018_929_Fig6_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14865_13046_2018_929_Fig6_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14865_13046_2018_929_Fig6_HTML.jpg?time\u003d20240507','sortOrder':'94','description':'Fig. 6 The influence of apigenin on B16-F10 melanoma xenograft tumor growth and host T cell immunity. a B16-F10 melanoma cells were subcutaneously inoculated into female C57BL/6 wild-type mice. After 4 days, xenograft-bearing mice were randomly divided into 3 groups to receive saline (control), curcumin, or apigenin by daily oral gavage for 12 consecutive days, before sacrifice and tumor resection. b B16-F10 xenograft tumor volume was measured every other day during the treatment and plotted. c the weight of resected B16-F10 xenograft tumor was measured and plotted. d tumor tissue sections were analyzed by immunohistochemistry using anti-Ki-67, anti-CD4, and anti-CD8 antibodies. Scale bar \u003d 50 mum. Magnified insets show CD4 or CD8 positive stained cells. e tumor tissues were lysed to detect PD-L1 expression by immunoblotting. GAPDH was used as a loading control. f splenocyte preparations from different groups were analyzed by flow cytometry with CD4 and CD8 antibodies. g the quantitation of CD4 and CD8 positive cells from different treatment groups in F (total population as 100%). h spleen/body weight ratios of mice with different treatments. i C57BL/6 mice with 3 groups were treated by oral gavage with saline, curcumin (50 mg/kg), or apigenin (150 mg/kg) once a day for 2 weeks. DCs were isolated from mouse spleens and PD-L1 expression in DCs was then detected by immunoblotting. Bar chart shows relative quantification of PD-L1 levels (control as 100%). GAPDH was used as a loa','shortDescription':'Fig. 6 The influence of apigenin on B16-F10 melanoma xenograft tumor growth and host T cell immunity. a B16-F10 melanoma cells were subcutaneously inoculated into female C57BL/6 wild-type mice. After 4 days, xenograft-bearing mice were randomly divided into 3 groups to receive saline (control), curcumin, or apigenin by daily oral gavage for 12 consecutive days, before sacrifice and tumor resection. b B16-F1... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Oct 29, 2018, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of experimental \u0026 clinical cancer research : CR','journalText':'Journal of experimental \u0026 clinical cancer research : CR 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14865_13046_2018_929_Fig6_HTML.jpg','benchSciPubmedId':'30373602'},{'sku':'11-0041-82','imageId':'923079','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14868_nihms-1008414-f0001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14868_nihms-1008414-f0001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14868_nihms-1008414-f0001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14868_nihms-1008414-f0001.jpg?time\u003d20240507','sortOrder':'95','description':'Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry','shortDescription':'Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Laboratory investigation; a journal of technical methods and pathology','journalText':'Laboratory investigation; a journal of technical methods and pathology 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14868_nihms-1008414-f0001.jpg','benchSciPubmedId':'30353130'},{'sku':'11-0041-82','imageId':'519419','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_4799_41467_2018_6227_Fig6_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_4799_41467_2018_6227_Fig6_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_4799_41467_2018_6227_Fig6_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_4799_41467_2018_6227_Fig6_HTML.jpg?time\u003d20240507','sortOrder':'96','description':'Fig. 6 Co-infection induces early apoptosis of CD4 + T cells in the popliteal lymph node (pLN). Joint inflammation ( a ), viraemia ( b ) and viral load in the whole body ( c ) and footpad ( d ) of WT + CHIKV ( n \u003d 5), WT + CHIKV + PbA ( n \u003d 5), LTa -/- + CHIKV ( n \u003d 4) and LTa -/- + CHIKV + PbA ( n \u003d 4) groups. The orange box denotes suppression of joint inflammation (5-8 dpi) in co-infected WT mice compared to WT + CHIKV, which is lost in the co-infected LTa - / - mice. Data from co-infected mice was compared with their respective CHIKV infected controls on the same genetic background using Mann-Whitney two-tailed analysis. Comparisons between WT + CHIKV and WT + CHIKV + PbA are represented by *P \u003c 0.05 and **P \u003c 0.01; comparisons between LTa -/- + CHIKV and LTa -/- + CHIKV + PbA are represented by + P \u003c 0.05. Quantification of CHIKV-specific CD4 + T cells (ELISPOT) ( e ), total CD4 + T cells (flow cytometry) ( f ) and late apoptotic CD4 + T cells ( g ) in the pLN of mock, CHIKV and CHIKV + PbA ( n \u003e\u003d 5 per group) at 2, 4, 5 and 6 dpi. e Representative ELISPOT images showing spots generated by virus-stimulated CD4 + T cells isolated from 100,000 pLN cells (4 and 5 dpi) and 200,000 pLN cells (6 dpi) in CHIKV-infected and co-infected mice. g Representative dot plots displaying late apoptotic CD4 + T cells gating on 6 dpi. Late apoptotic CD4 + T cells are defined as CD45 + CD3 + CD4 + FVD + AnnexinV + cells. Data shown are pooled from four independent','shortDescription':'Fig. 6 Co-infection induces early apoptosis of CD4 + T cells in the popliteal lymph node (pLN). Joint inflammation ( a ), viraemia ( b ) and viral load in the whole body ( c ) and footpad ( d ) of WT + CHIKV ( n \u003d 5), WT + CHIKV + PbA ( n \u003d 5), LTa -/- + CHIKV ( n \u003d 4) and LTa -/- + CHIKV + PbA ( n \u003d 4) groups. The orange box denotes suppression of joint inflammation (5-8 dpi) in co-infected WT mice c... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 25, 2018, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_4799_41467_2018_6227_Fig6_HTML.jpg','benchSciPubmedId':'30254309'},{'sku':'11-0041-82','imageId':'519418','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_4799_41467_2018_6227_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_4799_41467_2018_6227_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_4799_41467_2018_6227_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_4799_41467_2018_6227_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'97','description':'Fig. 5 Co-infection limits pathogenic CD4 + T-cell and pro-inflammatory immune-cell infiltration into the joints. a Representative IHC images of CD3 staining in the joints at 6 dpi. Scale bar: 100 mum. Quantification of CD3 + cells (IHC) ( b ), CD3 + cells (flow cytometry) ( c ), activated (LFA-1 + ) CD4 + T cells (flow cytometry) ( d ) and CHIKV-specific CD4 + T cells (ELISPOT) ( e ) in the joints of CHIKV, CHIKV + PbA and Py17x (-4 dpi) + CHIKV ( n \u003e\u003d 5 per group) at 6 dpi. Flow cytometric quantification of neutrophils ( f ), NK cells ( g ) and CD11b + Ly6C + monocytes ( h ) in the joints of CHIKV, CHIKV + PbA and Py17x (-4 dpi) + CHIKV ( n \u003e\u003d 5 per group) at 6 dpi. Data represent the means +- SD and were analyzed by one-way ANOVA with Tukey post hoc test ( *P \u003c 0.05, **P \u003c 0.01 and * **P \u003c 0.001). Each data point in the dot plot represents one mouse. Data are representative of two independent experiments. Activated CD4 + T cells are defined as CD45 + /CD3 + CD4 + /LFA-1 + cells. Neutrophils and NK cells are defined as CD45 + /CD11b + /Ly6G + and CD45 + /NK1.1 + cells, respectively. CD11b + /Ly6C + monocytes were gated after gating out all T cells, neutrophils, NK cells and B cells. Abbreviations: CHIKV, Chikungunya virus; dpi, days post infection; IHC, immunohistochemistry; NK, natural killer; ns, not significant; PbA, Plasmodium berghei -ANKA','shortDescription':'Fig. 5 Co-infection limits pathogenic CD4 + T-cell and pro-inflammatory immune-cell infiltration into the joints. a Representative IHC images of CD3 staining in the joints at 6 dpi. Scale bar: 100 mum. Quantification of CD3 + cells (IHC) ( b ), CD3 + cells (flow cytometry) ( c ), activated (LFA-1 + ) CD4 + T cells (flow cytometry) ( d ) and CHIKV-specific CD4 + T cells (ELISPOT) ( e ) in the joints of CHI... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 25, 2018, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_4799_41467_2018_6227_Fig5_HTML.jpg','benchSciPubmedId':'30254309'},{'sku':'11-0041-82','imageId':'922889','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14844_12974_2018_1304_Fig6_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14844_12974_2018_1304_Fig6_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14844_12974_2018_1304_Fig6_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14844_12974_2018_1304_Fig6_HTML.jpg?time\u003d20240507','sortOrder':'98','description':'Fig. 6 Microglia ablation in APP-PS1 mice resulted in increased CD3 + /CD8 + T-cell numbers in the brain, and CD8 + T-cell numbers were highly increased in cortical brain regions of APP-PS1 mice interacting with Iba1 + /TMEM119 + and Iba1 + /TMEM119 - cells. Detailed immunohistochemical analysis of CD8 + T-cell numbers (green) in brains of APP-PS1 mice revealed similar CD8 + T-cell numbers compared to WT when analyzing total sagittal brain sections; however, CD8 + T-cell numbers were significantly increased in cortical brain regions of APP-PS1 mice compared to WT ( a ). T-cells were mechanically isolated from total brain hemispheres and quantitatively analyzed by flow cytometry after ablation of microglia cells ( b , gated for single-living CD45 + /CD3 + cells; CD4 + red, CD8 + green). The total number of CD45 + /CD3 + T-cells was significantly increased in APP-PS1 mice treated with PLX5622 compared to WT-treated mice ( c ). CD3 + /CD4 + T-cell numbers trend to be increased in APP-PS1 mice treated with PLX5622 ( d ). CD3 + /CD8 + T-cell numbers were significantly increased in APP-PS1 mice treated with PLX5622 compared to APP-PS1 and WT PLX5622-treated mice ( e ). CD8 + T-cells in APP-PS1 mice were located directly in the brain parenchyma and observed in different interaction types with Iba1 + cells (white), showing either no contact, intermediate, or very tight interaction with brains Iba1 + cells ( f ). Performing confocal microscopy, we observed very tight cell to cell inte','shortDescription':'Fig. 6 Microglia ablation in APP-PS1 mice resulted in increased CD3 + /CD8 + T-cell numbers in the brain, and CD8 + T-cell numbers were highly increased in cortical brain regions of APP-PS1 mice interacting with Iba1 + /TMEM119 + and Iba1 + /TMEM119 - cells. Detailed immunohistochemical analysis of CD8 + T-cell numbers (green) in brains of APP-PS1 mice revealed similar CD8 + T-cell numbers compared to WT wh... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 21, 2018, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of neuroinflammation','journalText':'Journal of neuroinflammation 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14844_12974_2018_1304_Fig6_HTML.jpg','benchSciPubmedId':'30241479'},{'sku':'11-0041-82','imageId':'922910','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14844_12974_2018_1304_MOESM7_ESM.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14844_12974_2018_1304_MOESM7_ESM.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14844_12974_2018_1304_MOESM7_ESM.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14844_12974_2018_1304_MOESM7_ESM.jpg?time\u003d20240507','sortOrder':'99','description':'Additional file 7: Figure S7. Flow cytometric data of brain isolated T-cells were analyzed for gender-specific differences: (A) Female APP-PS1 mice had significantly increased numbers of CD3 + T-cells when compared specifically to female WT mice, however this was not seen in male mice (B). (C) Female APP-PS1 had increased numbers of CD3 + T-cells compared to male APP-PS1 mice. (D) The number of CD3 + /CD4 + T-cells was significantly increased in female APP-PS1 compared to female WT mice, whereas male mice of both genotypes had the same cell numbers in the brain (E). (F) APP-PS1 female mice had higher numbers of CD3 + /CD4 + T-cells compared to male APP-PS1 mice. (G) There was a trend for higher CD3 + /CD8 + T-cell numbers in the brain of female APP-PS1 mice compared to female WT mice, however this was not seen in male animals (H). (I) Female APP-PS1 mice had higher numbers of CD3 + /CD8 + T-cells compared to male APP-PS1 animals. PLX5622 treatment in APP-PS1 mice of both sexes showed an increase in the number of CD3 + , CD3 + /CD4 + and CD3 + /CD8 + T-cells in the brain. One-way ANOVA with Tukey\u0027s Multiple Comparison Test (A, B, D, E, G, H, n \u003d 3-5/group) and Unpaired Student\u0027s T-test (A, C, D, F, G, I) for comparison of only two groups were performed (n \u003d 3-5/group). (TIF 743 kb)','shortDescription':'Additional file 7: Figure S7. Flow cytometric data of brain isolated T-cells were analyzed for gender-specific differences: (A) Female APP-PS1 mice had significantly increased numbers of CD3 + T-cells when compared specifically to female WT mice, however this was not seen in male mice (B). (C) Female APP-PS1 had increased numbers of CD3 + T-cells compared to male APP-PS1 mice. (D) The number of CD3 + /CD4 +... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD4 Antibody in Flow Cytometry (Flow)','title':'CD4 Antibody (11-0041-82) in Flow','appAbv':'Flow','dateTime':'Sep 21, 2018, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of neuroinflammation','journalText':'Journal of neuroinflammation 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14844_12974_2018_1304_MOESM7_ESM.jpg','benchSciPubmedId':'30241479'}],'Advanced Verification':[{'sku':'11-0041-82','imageId':'132340','imageUrl':'https://www.thermofisher.com/antibody/images/650/11004182-CD4-GK1-5-RE-AV-20170920122035.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/11004182-CD4-GK1-5-RE-AV-20170920122035.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/11004182-CD4-GK1-5-RE-AV-20170920122035.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/11004182-CD4-GK1-5-RE-AV-20170920122035.jpg?time\u003d20240507','sortOrder':'1','description':'Staining of mouse splenocytes. As expected based on known relative expression patterns, CD4 clone GK1.5 stains about 25% of total lymphocytes and does not stain CD45R (B220)+ B cells. Details: Balb/c splenocytes were surface stained with CD45R (B220, clone RA3-6B2) and Rat IgG2b Isotype Control or CD4 (clone GK1.5). Cells in the lymphocyte gate were used for analysis. {RE}','shortDescription':'Staining of mouse splenocytes. As expected based on known relative expression patterns, CD4 clone GK1.5 stains about 25% of total lymphocytes and does not stain CD45R (B220)+ B cells. Details: Balb/c splenocytes were surface stained with CD45R (B220, clone RA3-6B2) and Rat IgG2b Isotype Control or CD4 (clone GK1.5). Cells in the lymphocyte gate were used for analysis. {RE}','altTag':'CD4 Antibody','title':'CD4 Antibody (11-0041-82)','appAbv':'RE','appName':'Relative expression','type':'Advanced Verification','journalText':'','sourceType':'2','benchsci':false,'imageName':'11004182-CD4-GK1-5-RE-AV-20170920122035.jpg','benchSciPubmedId':'0'}]}" image-displayed-id="'731944'" product-sub-type="'antibody_primary'" prod-type="'antibody'" page-type="PDP" product-id="'11-0041-82'"> <div class="tabs"> <ul class="nav nav-pills"> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Antibody Testing Data"> <a class="tab-text"> Antibody Testing Data (1) </a> </li> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Published Figures"> <a class="tab-text"> Published Figures (97) </a> </li> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Advanced Verification"> <a class="tab-text"> Advanced 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src="https://www.thermofisher.com/antibody/images/150/tfs_8134_10.1177_2040622319860653-fig4.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="735283" data-index="78"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_8134_10.1177_2040622319860653-fig6.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="923121" data-index="79"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14869_JCMM-23-5588-g006.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="735281" data-index="80"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_7860_fgene-10-00545-g001.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="923100" data-index="81"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_5889_gr5.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="850570" data-index="82"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_8325_nihms-1528318-f0009.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="923058" data-index="83"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14867_ADVS-6-1802042-g004.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="923142" data-index="84"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14870_acd-30-909-g002.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="735280" data-index="85"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_8142_MI2019-4652596.005.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="922995" data-index="86"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14826_41598_2018_37175_Fig9_HTML.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="923016" data-index="87"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14866_biolopen-8-036244-g5.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="923037" data-index="88"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14866_biolopen-8-036244-g6.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="519420" data-index="89"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_5004_elife-37851-fig1.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="519421" data-index="90"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_5004_elife-37851-fig3.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="519422" data-index="91"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_5004_elife-37851-fig3-figsupp4.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="922974" data-index="92"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14865_13046_2018_929_Fig6_HTML.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="923079" data-index="93"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14868_nihms-1008414-f0001.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="519419" data-index="94"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_4799_41467_2018_6227_Fig6_HTML.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="519418" data-index="95"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_4799_41467_2018_6227_Fig5_HTML.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="922889" data-index="96"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14844_12974_2018_1304_Fig6_HTML.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="922910" data-index="97"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14844_12974_2018_1304_MOESM7_ESM.jpg?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="132340" data-index="98"> <img src="https://www.thermofisher.com/antibody/images/150/11004182-CD4-GK1-5-RE-AV-20170920122035.jpg?time=20240507" alt="CD4 Antibody"/> </div> </div> </div> </div> </div> <noscript> <div itemscope itemtype="http://schema.org/ImageGallery"> <h2>Product Image Gallery</h2> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/11-0041-82CD4Flow1_20201009083253.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Staining of mouse thymocytes with Anti-Mouse CD8a PE (Product # 12-0081-82) (left) or mouse splenocytes with Anti-Mouse CD3e PE (Product # 12-0031-82) (right) and Anti-Mouse CD4 FITC. Total viable cells were used for analysis.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29057_13287_2023_3484_Fig7_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 7 CRISPLD2 mediates hUCMSC repressing the differentiation of Th0 cells into Th2 cells. A qRT-PCR analysis of crispld2 knockdown efficiency in hUCMSCs transfected with shRNA for the non-targeting sequence (shControl-hUCMSCs) or shRNA for the crispld2 sequence (shCrispld2-hUCMSCs). B The protein level of CRISPLD2 was detected by Western blot, full-length blots are presented in Additional file 4 : Fig. S3. C Quantitative analysis of the expression level of CRISPLD2 ( n = 3). D qRT-PCR was performed to evaluate crispld2 mRNA expression in shCrispld2-hUCMSCs treated with EAC mouse serum ( n = 3). E , F The proportion of CD4 + IL-4 + cells were analyzed by flow cytometry E and quantitative analysis F in different groups ( n = 3). G , H CD4 + T cells were labeled with CFSE, and the proliferation of CD4 + T cells was analyzed by flow cytometry G and quantitative analysis H in different groups ( n = 3). I The protein expression of phosphorylated and total STAT6 in CD4 + T cells was detected by Western blot, full-length blots are presented in Additional file 4 : Fig. S3. J Quantitative analysis of the expression level of p-STAT6 ( n = 3). The data are expressed as mean +- SD, * P < 0.05, ** P < 0.01, and *** P < 0.001</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29057_13287_2023_3484_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 3 hUCMSCs change CD4 + T lymphocyte subsets in CLNs that are detected by flow cytometry. A CD4 + T cells in CLNs were gated by flow cytometry. B The proportion of Th1, Th2, and Treg cells among CD4 + T cells in CLNs was analyzed by flow cytometry. C Quantitative analysis of the proportion of Th1, Th2, and Treg cells among CD4 + T cells ( n = 3). The data are expressed as mean +- SD, * P < 0.05, ** P < 0.01</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29059_NRR-19-671-g004.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fasudil-modified macrophages affect T cell polarization. A mouse model of chronic EAE was induced by subcutaneous injection of myelin oligodendrocyte glycoprotein peptde 35-55. Macrophages from EAE mice isolated with magnetic beads were treated with 15 mug/mL of Fasudil at 37degC in 5% CO 2 atmosphere for 72 hours. Fasudil-treated macrophages were suspended in PBS at a concentration of 2 x 10 7 cells/200 muL and intraperitoneally injected into EAE mice on days 3 and 11 postimmunization. PBS-treated macrophages were used as a control. The mice were randomly divided into two groups: the Fasudil-macrophage group (Fasudil-Mphi) (n =12) and the PBS-macrophage group (PBS-Mphi) (n = 12). On day 28 p.i., splenic MNCs were prepared and stained with anti-CD4 (for CD4 + T cells), IFN-gamma (for Th1), IL-17 (for Th17), and IL-10 (for Th2) antibodies, and T cell subsets were analyzed by flow cytometry. Injection of Fasudil-modified macrophages decreased the percentage of CD4 + IL-17 + T cells and increased the percentage of CD4 + IL-10 + T cells. Quantitative results are shown for five mice from each group. The results are expressed as the percentage of double positive cells in the four-quadrant diagram. Data are presented as the mean +- SEM. ** P < 0.01, *** P < 0.001 (Student's t -test). EAE: Experimental autoimmune encephalomyelits; IFN-gamma: interferon-gamma; IL-10:interleukin-10; IL-17:interleukin-17; MNCs: mononuclear cells; Mphi: macrophage; PBS: phosphate buffer saline.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29056_gr6.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">IgM contained in B cell-derived EV can bind antigen CH12 cells were cultured in media alone for two days, after which the conditioned media was subjected to differential ultracentrifugation (DUC) to isolate EV. The EV samples (2kG, 11kG, and 110kG) were resuspended in an equivalent volume of buffer for subsequent analysis by immunoblot and ELISA. (A) An equivalent proportion of each sample was resolved by SDS/PAGE under unreduced conditions, and immunoblotted for IgM and CD81. CH12 cell lysate (lane 1; 7.5 mug) and 110kG supernatant (lane 5), were run as controls. (B) The amount of IgM in each EV sample under buffer +0.25% TX100 conditions was determined by anti-mouse IgM ELISA. For (A) and (B), data are representative of two independent experiments. (C) CH12 cells were incubated with PtC liposomes for 30 min on ice at 1:2000 stock and at sequential 1:2 dilutions thereof, after which FITC fluorescence was determined by flow cytometry and GMI determined. The extreme left data point is the GMI FITC for CH12 cells incubated in buffer only. The turquoise arrowhead indicates the reagent concentration (1:5000 stock) utilized for subsequent experiments. (D) WEHI 231 and CH12 cells were stained with IgM APC and PtC liposome FITC reagent for flow cytometry analysis. Dot plots indicate FMO PtC liposome (first row), FMO IgM APC (second row), and complete stain (third row) fluorescence profiles of single, viable WEHI-231 (left column) and CH12 (right column) cells. (E) EV samples (11kG a</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29046_urn-x-wiley-20457634-media-cam46242-cam46242-fig-0005.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">5 FIGURE Inhibition of YAP could affect TME and tumor proliferation through the STAT3/VEGF/VEGFR-2 axis. (A) The detection of volume and weight of tumors of mice. (B) The tumor morphological changes of mice were observed by HE staining. (C) YAP expression of tumor tissues was tested by RT-qPCR. (D) CD3 + CD4 + , CD3 + CD8 + , and treg cells in tumor tissues were examined by flow cytometry. (E) The ratio of M1 and M2 macrophages in tumor tissues was tested by flow cytometry. (F) The iNOS, IL-12, IL-10, TGF-beta, Arg-1, and CCL-22 expressions were tested by ELISA. (G) IF staining was selected to examine the YAP, STAT3, and p-STAT3 expression levels in tumor tissues. The red signal represented positive staining for YAP, p-STAT3, and STAT3, while the blue signal indicated nuclear staining. (H) The levels of YAP, STAT3, p-STAT3, VEGF, VEGFR-2, and PD-L1 in tumor tissues were examined by WB. All data were presented as mean +- SD ( n = 3) from three independent experiments, each performed in triplicate. *** p < 0.001, ** p < 0.01, * p < 0.05 vs the model group. One-way ANOVA (A, left and B-H). Two-way ANOVA (A, right).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29051_41598_2023_35328_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Increased T cell-mediated immune responses by rAd5-Gn priming and Gn protein boosting. Six-week-old C57BL/6 mice ( n = 5/group) are immunized intramuscularly with 1 x 10 8 infectious units of rAd5-Gn or alum and RNA-adjuvanted Gn protein at 0 and 2 weeks. Mice are sacrificed one week after boosting. ( a , d , g) , and ( j ) Representative flow cytometry plots showing ( a ) follicular helper T cells, ( d ) effector T cells, central memory t cells, ( g ) interferon gamma cytokine-producing T cells, ( j ) activated T cells. Frequencies of ( b ) CXCR5, ( c ) PD-1 expression in CD4 T cell, and ICOS expression in CD4 PD-1 populations from immunized mice spleen. Frequencies of ( e ) effector memory T cells and ( f ) central memory T cells in CD4 T cells were analyzed using flow cytometry. IFN-gamma-producing ( h ) CD4 and ( i ) CD8 T cells in the spleen were analyzed using flow cytometry. ( k ) CD69 and ( l ) CD25 expression in CD4 T cells in the spleen was analyzed using flow cytometry. Data are presented as mean values + SD. P values are calculated using one-way ANOVA with Bonferroni multiple comparison test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24723_JIR2022-9543083.004.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 4 IL-33 deficiency inhibited Th17 cells in murine ARDS. (a) The percentage of CD4+ IL-17+CD4+ T cells in the lung was detected by flow cytometry. (b) The mRNA expression of ROR gamma t in the lung was measured by real-time PCR. (c) The protein expression of ROR gamma t in lung tissue was measured by Western blotting. (d) The concentrations of IL-17 and IL-22 in BALF were detected by ELISA. The data are expressed as the means +- SDs. Significant differences are shown by * P < 0.05, ** P < 0.01, and *** P < 0.001 by one-way ANOVA followed by Bonferroni's post hoc test comparing the WT control, LPS, LPS+rmIL-33, and LPS+IL-33 -/- groups. N = 3-5 for each group, and three independent repeated experiments were carried out.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24720_AD-13-6-1919-g6.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 6. CD4 + CTLs mediated allograft rejection of MSCs with MHC-II upregulation. (A and B) after co-culture with untreated MSCs, LICM-treated MSCs and LICM-treated MHC-II -/- MSCs respectively, allogeneic splenocytes were labeled with fluorochrome-conjugated anti-CD45, CD4, Fas-L, Perforin mAbs, then proliferation of CD4 + CTLs (ratio of CD4 + Fas-L + T cell and CD4 + Perforin + T cell in total CD4 + T cells) was analyzed by flow cytometry (n = 3). The results are representative of three independent experiments as mean +- SD. ** p < 0.01. (C and D) untreated MSCs, LICM-treated MSCs and LICM-treated MHC-II -/- MSCs were mixed with Matrigel respectively and injected subcutaneously in allogeneic mice; Matrigel was retrieved 7 days after injection, infiltrated cells were isolated and labeled with anti-CD4, Fas-L, Perforin mAbs, cell numbers of infiltrated CD4 + CTLs (CD4 + Fas-L + T cell and CD4 + Perforin + T cell) were analyzed by flow cytometry (n = 5). The results are representative of at least three independent experiments as mean +- SD. * p < 0.05, ** p < 0.01. (E) MSCs survival in Matrigel was determined after injection, cells in retrieved Matrigel were isolated and labeled with anti-MHC-I mAb (specific to H-2 b haplotype), cell numbers of survived MSCs were analyzed by flow cytometry (n = 5). The results are representative of at least three independent experiments as mean +- SD. ** p < 0.01, *** p < 0.001. (F) MSCs and MHC-II -/- MSCs were treated with LICM, mixed with</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24722_41419_2022_5461_Fig6_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 6 CB-5083 treatment of LCMV-infected mice after the priming phase strongly impairs health status. C57BL/6 mice were infected with LCMV and treated on d6 post-infection with 50 mg/kg CB-5083 or vehicle. Mice were analyzed 6 h post-CB-5083 treatment. A The movement of the mice was tracked and the individual numbers of steps in 1 min were counted. Values represent mean +- SD. Pooled data ( n = 12) derived from two separate experiments were analyzed by unpaired t test. B IL-1beta, IL-6, TNF-alpha, and IFN-gamma concentrations were determined in the serum ( n = 5-12). Values represent mean +- SD. For each analysis, a Kruskal-Wallis test followed by a Dunn's test was performed. C , D The blood ( C ) ( n = 27-32) and spleen ( D ) ( n = 16-17) were collected and stained for CD4, CD8, CD11b, CD19, F4/80 and NK1.1 and analyzed by flow cytometry. The data was pooled from three different experiments and analyzed by unpaired t test. Values represent mean +- SD. E Splenocytes were lysed and analyzed via immunoblot for poly-ubiquitin accumulation, BiP, and p-eIF2alpha. On the gamma -axis, the mean signal normalized to gamma-tubulin +- SD from mice ( n = 6) derived from two independent experiments analyzed by an unpaired t test is shown. All values represent mean +- SD. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24722_41419_2022_5461_Fig4_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Analysis of immune cells in the spleen of LCMV-infected CB-5083-treated mice. C57BL/6 mice were infected with LCMV (d0), or left uninfected ( A , B ), and treated with 50 mg/kg CB-5083 or vehicle on d0 and d2 post-infection. Spleens were collected on d2 ( A ), d4 ( B ), d6 ( C ), and d8 ( D ). Splenocytes were stained for CD8, CD4, CD11b, CD19, F4/80, and NK1.1 and analyzed by flow cytometry. On the gamma -axis, the absolute cell number of each population is shown. Values represent mean +- SD ( n = 5-12 per group). A and B were analyzed by individual ordinary one-way ANOVA or Kruskal-Wallis test with multiple corrections performed by Tukey or Dunn's test, respectively. C and D were analyzed by unpaired t test or Mann-Whitney test. For each day analyzed, the data were pooled from two independent experiments. All values represent mean +- SD. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24722_41419_2022_5461_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Analysis of immune cells in the blood of LCMV-infected CB-5083-treated mice. C57BL/6 mice were infected with LCMV (d0), or left uninfected ( A , B ), and treated with 50 mg/kg CB-5083 or vehicle on d0 and d2 post-infection. Blood samples were collected on d2 ( A ), d4 ( B ), d6 ( C ), and d8 ( D ). Blood cells were stained for CD8, CD4, CD11b, CD19, F4/80, and NK1.1 and analyzed by flow cytometry. On the gamma -axis, the absolute cell number/ul of blood of each population is shown. Values represent mean +- SD ( n = 5-11 per group). A and B were analyzed by individual ordinary one-way ANOVA or Kruskal-Wallis test with multiple corrections performed by Tukey or Dunn's test, respectively. C and D were analyzed by unpaired t test or Mann-Whitney test. Data was pooled from two independent experiments. All values represent mean +- SD. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24721_gr4_lrg.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 4 SARS-CoV-2-specific T cell immune responses and memory-biased immunity in pSpike/PP-sNP vaccinated mice. Enzyme-linked immunospot (ELISpot) analyses of a ) IFN-gamma and b ) IL-4 spot-forming cells in pulmonary lymphocyte after re-stimulation with peptide pools of 14-mer overlapping peptides spanning the SARS-CoV-2 receptor binding domain (RBD) region. c ) CD4 + T cells and d ) CD8 + T cells in the lung were assayed for IFN-gamma + expression by flow cytometry after re-stimulation with the SARS-CoV-2 RBD peptide pool. e ) CD4 + T cells in the lung were analyzed for IL-4 + expression via flow cytometry in the same way as describe above. f ) Percentage of CD4 + effector memory T cells (T EM ) co-expressing CD44 hi and CD62L lo and central memory T cells (T CM ) co-expressing CD44 hi and CD62L hi in the lung of mice 35 days after priming. g ) Percentage of CD8 + T EM and T CM in lung of mice 35 days after priming. h ) Percentage of CD4 + T RM and i ) CD8 + T RM in lung of mice 35 days after initial vaccination. Data in a-i represent mean +- SEM (n = 5 biologically independent samples). One-way ANOVA with Dunnett's post-hoc test was used to determine significance (** P < 0.01, *** P < 0.001, **** P < 0.0001). Fig. 4</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24719_DM2022-1542112.008.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Characterization of isolated CD4+ T cells stimulated with IFN- gamma . CD4+ T cells were extracted from the spleen of C57BL/6 mice and stimulated with 100 ng/mL IFN- gamma for 20, 60, or 120 min. (a) Flow cytometry validation of T cell differentiation into Th9 subset with or without IFN- gamma stimulation. Cells expressing IL-9 were identified as Th9 cells. (b) qRT-PCR analysis of expression of IL-9 mRNA in unstimulated and IFN- gamma -stimulated T cells. (c) ELISA of secreted IL-9 in unstimulated and IFN- gamma -stimulated T cells. (d) qRT-PCR of expression of T-bet mRNA in unstimulated and IFN- gamma -stimulated (20, 60, or 120 min) T cells. (e) Western blot analysis and quantification of the phosphorylation of STAT1 and STAT3 (relative to total protein content) in unstimulated and IFN- gamma -stimulated (20, 60, or 120 min) T cells. Results are presented as mean +- SD ( n = 3), * p < 0.05. IFN: interferon; IL: interleukin; STAT: signal transducer and activator of transcription.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24551_fnagi-14-842380-g006.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">FIGURE 6 The effect of rotenone on subpopulations of Peyer's patches lymphocytes in halpha-syn +/- mice. Flow cytometry was used to detect the changes in lymphocyte subsets, namely, CD4 + , CD8 + , and CD4 + CD25 + lymphocytes, respectively, in Peyer's patches in mice of different ages. (A) Changes of lymphocyte subsets in Peyer's patches of 6-month-old halpha-syn +/- mice by flow cytometry, n = 6. (B) Statistics of the number of cells in Peyer's patches of 6-month-old halpha-syn +/- mice. (C) Changes of lymphocyte subsets in Peyer's patches of 12-month-old halpha-syn +/- mice by flow cytometry, n = 6. (D) Statistics of the number of cells in Peyer's patches of 12-month-old halpha-syn +/- mice.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20554_ijms-23-04482-g006.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Effect of Compound A on the spleen sizes and CD4 + IL-17A + T cell population in FFA4 WT and KO mice. ( A ) The spleens were photographed to record morphological changes. ( B ) Representative flow cytometry dot plots of the FACS analysis of CD4 + IL-17A + T cells. ( C , E ) The measured weights of spleens. ( D , F ) Percentage of CD4 + IL-17A + T cells in the spleens. Data was tested for Gaussian distribution using the KS normality test. The results are presented as the mean +- SEM (n = 5). *** p < 0.001, ** p < 0.01, * p < 0.05 vs. the vehicle-treated group, ### p < 0.001, ## p < 0.001 vs. the imiquimod-treated group.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20554_ijms-23-04482-g004.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Effect of Compound A on the lymph node sizes and CD4 + IL-17A + T cell population in FFA4 WT and KO mice. ( A ) The draining lymph nodes were photographed to record morphological changes. ( B ) Representative flow cytometry dot plots of the FACS analysis of CD4 + IL-17A + T cells. ( C , E ) The measured weights of lymph nodes. ( D , F ) Percentage of CD4 + IL-17A + T cells in the lymph nodes. Data were tested for Gaussian distribution using the KS normality test. The results are presented as the mean +- SEM (n = 5). *** p < 0.001 vs. the vehicle-treated group, ### p < 0.001, # p < 0.05 vs. the imiquimod-treated group.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20553_ppat.1010407.g005.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">10.1371/journal.ppat.1010407.g005 Fig 5 Chitinase facilitates in vivo invasion, survival, and pathogenesis of Salmonella Typhimurium. (A) Survival of the mice infected with a lethal dose of STM WT and STM Delta chiA (PBS = Phosphate Buffered Saline). Data are presented from one independent experiment, representative of 3 independent experiments (N = 3). (B) Bacterial shedding in the feces of STM WT and STM Delta chiA infected animals. Data are presented as mean +- SD of 3 independent experiment; each dot represents an individual animal (N = 3, n = 10). (C) In vivo invasion in PP by STM WT and STM Delta chiA . (N = 3). Bacterial burden in (D) liver, (E) spleen, (F) MLN and (G) PP of the infected mice after the indicated time with a sub-lethal dose of STM WT and STM Delta chiA . (N = 3). Unpaired Student's t test was used to analyze the data for C-G . (H) Body weight of the infected mice 5 dpi with a sub-lethal dose of STM WT and STM Delta chiA . (N = 3). (PBS- Phosphate Buffered Saline). (I) Flow cytometry analysis of CD4 + and CD25 + T cells from total splenocytes isolated from STM WT and STM Delta chiA infected mice 20 dpi (US-PBS- Unstained splenocytes from PBS treated mouse). Data are presented from one independent experiment, representative of 3 independent experiments (N = 3). Pro-inflammatory cytokines (J) IL-2 and (K) IFN-gamma level in serum from STM WT and STM Delta chiA infected mice after the indicated time. (N = 3); One-way ANOVA was used to analyze the data. (L)</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19032_fimmu-12-786680-g006.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 6 Depletion of CD8 + T-lymphocytes lowers reparative MoMFs and impairs the resolution of acute liver injury. Mice were treated with an anti-CD8 monoclonal antibody (mAb) 72 hours before and immediately after CCl 4 administration and the evolution of hepatic injury was evaluated 48 hours after CCl 4 poisoning. The distribution of liver and circulating CD4 + and CD8 + T cells and that of hepatic CD11b + /F4-80 + MoMFs was monitored by flow cytometry in mice receiving CCl 4 (A) . The lowering of CD11b + /F4-80 + MoMFs induced by CD8 T-cell ablation involved CD206, TREM-2 and MerTK-expressing cells (B) . The effects of CD8 + T-depletion of the recovery from acute liver injury was evaluated by measuring alanine aminotransferase (ALT) release and histological analysis of liver sections stained with hematoxylin/eosin (magnification 10X) (C) .</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19031_vaccines-09-01247-g008.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 8 Flow cytometry analysis of T cells in the tumors treated with SFV/IFNg, SFV/Luc, or PBS in orthotopic 4T1 mouse breast cancer model (mice were treated as presented in Figure 6 d). Resected tumors were homogenized to obtain a single cell suspension, which was used for immunostaining with antibodies against surface markers (CD3, CD4, CD8, CD25) and intracellular markers (FoxP3) in one mixture. ( a ) Percentages of cell populations. Th cells were identified as CD3 + /CD4 + ; CTL cells as CD3 + /CD8 + , and T-regs as CD4 + /CD25 + /FoxP3 + populations. ( b ) Representative pictures of forward and side (SSC-A/FSC-A) scattering of the cell populations. Arrows indicate the increased population of lymphocytes in the SFV/IFNg group. Bars represent the means +- SD ( n = 5); * p < 0.05; ** p < 0.01; ns--nonsignificant.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19044_JAH3-10-e023077-g007.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 4 Depletion of Tregs in vivo abolished neuroprotection conferred by RLIPoC. A , Scheme for ablation of Tregs in DEREG mice (left) and purified Tregs transferring to recipient mice (right). Diphtheria toxin (DT; intraperitoneal, 50 ug/kg body weight) was administered 2 days before the MCAO model and was administered again with a dose of 10 ug/kg body weight every other day until the mouse was euthanized. Purified CD4 + CD25 + Tregs were transferred intravenously to recipient mice within 1 hour after the MCAO model, with a dose of 1 million per mouse through the tail vein. B , The efficacy of Tregs ablation in DEREG mice using DT. Representative flow cytometry plots and the quantitation of percentages of CD25 + Foxp3 + Tregs among CD4 + T cells in the blood and spleen are shown in the histogram. Student t test, * P <0.05 vs PBS. n=3 per group. C , Neuronal apoptosis was assessed by TUNEL staining at 3 days after MCAO. Representative confocal images of coronal sections labeled with TUNEL and NeuN; the quantitation of NeuN and TUNEL double positive cells are shown in the histogram. Scale bar=50 um. Kruskal-Wallis test with Dunn's post hoc test. n=6 per group. D , Representative magnetic resonance images and quantification of infarct volume at 3 days after MCAO. One-way ANOVA with Bonferroni's post hoc test. n=6 per group. DEREG indicates depletion of regulatory T cell; MCAO, middle cerebral artery occlusion; NeuN, neuronal nuclei; RLIPoC, remote limb ischemic postcondition</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19044_JAH3-10-e023077-g005.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 3 RLIPoC facilitated Tregs increase via modifying metabolic spectrum. A , Images of blood flow (top) and curves of the dynamic concentration changes of metabolites (FAD, Cytaa3-R, and Cytc-R) in the region of the hind limb underwent RLIPoC in vivo, which was monitored using a multispectral optical imaging system. O indicates occlusion of the bilateral femoral arteries; and R, reperfusion of the bilateral femoral arteries. B , Concentrations of NAD + and NADH, and the ratio of NAD + to NADH, in muscle that underwent RLIPoC. Student t test, * P <0.05, ** P <0.01 vs control. n=4 per group. C , Concentrations of NAD + and NADH and the ratio of NAD + to NADH in the blood. Student t test, * P <0.05, ** P <0.01 vs control. n=4 per group. D , Scheme for NADH administration. NADH (intraperitoneal 50 mg/mouse) was administered within 1 hour after the MCAO model, and the mouse was euthanized at 3 days after MCAO and NADH administration. E , Representative flow cytometry plots and quantitation of percentages of CD25 + Foxp3 + Tregs among CD4 + T cells in the blood and spleen after 3 days of MCAO are shown in the histogram. Student t test, * P <0.05, ** P <0.01 vs MCAO. n=5 to 6 per group. F , Representative confocal images of coronal sections labeled Tregs with EGFP, and quantification of EGFP-positive cells are shown in the histogram. Scale bar=50 um. Student t test, * P <0.05 vs MCAO. n=6 per group. Cytaa3-R indicates cytochrome aa3 in a reduced state; Cytc-R, cytochrome c in a</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19044_JAH3-10-e023077-g004.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 2 RLIPoC increases Tregs abundance in the blood, spleen, and brain. A , Representative flow cytometry plots of CD4 + CD25 + Foxp3 + Tregs in the blood and spleen on day 1, 3, and 7 after MCAO. B , Quantification of percentages of CD25 + Foxp3 + Tregs among CD4 + T cells in the blood and spleen. Student t test, * P <0.05, *** P <0.001 vs MCAO. n=5 to 6 per group. C , Representative flow cytometry plots and quantification of percentages of CD25 + Foxp3 + Tregs among CD4 + T cells in ipsilateral hemispheres on days 1, 3, and 7 after MCAO were shown in the histogram. Student t test, * P <0.05 vs MCAO. n=5 to 6 per group. D , Tregs number at peri-infarct area was evaluated using transgenic mice with EGFP-tagged Foxp3 at different time points after MCAO. Representative confocal images of coronal sections labeled Tregs with EGFP and quantification of EGFP-positive cells are shown in the histogram. Scale bar=50 um. Student t test, * P <0.05 vs MCAO. n=6 per group. EGFP indicates enhanced green fluorescence protein; MCAO, middle cerebral artery occlusion; RLIPoC, remote limb ischemic postconditioning; and Tregs, regulatory T cells.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19026_cancers-13-05019-g004.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)" title="CD4 Antibody (11-0041-82) in IHC, Flow"> <figcaption itemprop="caption">Figure 4 Proof-of-mechanism study for TAX2 use as an anti-tumor immunomodulatory drug. The effects of TAX2 peptide treatment on the activation of an anti-tumor immune response were investigated in two syngeneic models of epithelial ovarian carcinoma. We inoculated 5 x 10 6 ID8 cells either subcutaneously or intraperitoneally to C57BL/6JRj mice in order to mimic primary tumor growth ( a - h ) and metastatic dissemination (peritoneal carcinosis, i - l ), respectively. TAX2 treatments (30 mg * kg -1 BW) vs. vehicle injections (0.9% NaCl) were performed thrice weekly for 4 and 8 weeks for the s.c. and i.p. ID8 models, respectively ( n = 11 per group for both models). ( a - h ) IHC staining of s.c. ovarian carcinoma allografts for the analysis of the vascular/lymphovascular features, as well as immune-cell-infiltration profile. ( a ) Representative microphotograph for CD31 immunostaining of intra-tumor vascular structures. Histogram displays results of automated quantification for the percent of CD31-positive pixels across the whole tumor section (mean +- SEM, Mann-Whitney U test; n.s., not significant). ( b ) Lymphatic vessel density analysis. Microscopic views are shown, while histogram displays the number of Lyve-1-positive functional lymphatic vessels in 5 high power fields (HPF), as determined by a pathologist who was blinded to the treatment (mean +- SEM, Mann-Whitney U test, * p < 0.05). ( c - f ) Macroscopic views (x20 magnification) of s.c. tumor allograft sections after</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig4_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 4 Evaluation of enhanced ferroptosis induced by HGF-relative exosomal PD-L1 inhibition. a In vitro schedule for ferroptosis-relevant tests. b Relative IFN-gamma release from CD8 + T cells incubated in different conditions. n = 5 biologically independent samples per group. c Relative lipid ROS of B16F10 cells co-cultured with CD8 + T cells after incubating in PBS, HACA-Fe, HACA-GW, and HGF NPs for 48 h. n = 5 biologically independent samples per group. d CLSM observation of expression of SLC7A11 and SLC3A2 in B16F10 cells treated with PBS, HGF or HGF + IFN-gamma for 24 h. Scale bar: 20 mum. Experiments were performed three times independently with similar results. e GPX4 activity in B16F10 cells co-cultured with CD8 + T cells after incubating in PBS, HACA-Fe, HACA-GW, and HGF NPs. n = 5 biologically independent samples per group. f Schematic showing the experiment design for in vivo evaluations ( g - o ). n = 5 biologically independent animals per group. g The intratumoral IFN-gamma level after treatment. G1, PBS; G2, HACA-Fe; G3, HACA-GW; G4, HGF. h IFN-gamma secretion in serum. i and j Flow cytometric quantification of IFN-gamma + T cells after gating on CD3 + CD8 + T cells ( i ) and CD3 + CD4 + T cells ( j ) in TDLN. k Immunofluorescence assay for the expression of SLC7A11 and SLC3A2 in tumor tissues. Scale bar: 50 mum. l - o Cystine ( l ), GSH ( m ), GPX4 activation ( n ), and lipid ROS ( o ) levels in B16F10 tumor tissue after treatment. All data are presented as mea</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 3 HGF NPs inhibited exosomal PD-L1 and triggered robust immunostimulation. a Western blot analysis of exosome marker CD63 and PD-L1 via collecting the exosomes from the cell-free media of B16F10 cells with various treatments. GAPDH served as a loading control. Images were representative of the three experiments. b Scheme of in vivo experimental design for ( c - m ). C57BL/6 mice were subcutaneously inoculated with 1 x 10 6 B16F10 cells. When tumor volumes reached ~ 100 mm 3 , mice were treated with PBS, HACA-Fe, HACA-GW, or HGF on day 0, day 2, and day 4. Tumor and tumor-draining lymph node (TDLN) were collected on day 7 for further analysis. c Western blot analysis of exosome marker CD63 and PD-L1 in tumor tissues after treatment. Images were representative of the three experiments. d-f Flow cytometric plots ( d ) and quantification of CD8 + ( e ) and CD4 + ( f ) T cells, respectively, gated by CD3 + T cells in the TDLN ( n = 5) in groups of PBS (G1), HACA-Fe (G2), HACA-GW (G3), HGF (G4), and HGF + liproxstatin (G5). g-m Flow cytometric analysis of granzyme B + (GzmB + , g - i ), Ki67 + ( j and k ), and Tim3 + ( l and m ) in CD8 + and CD4 + T cells. n = 5 biologically independent animals per group. Data were presented as mean +- SD. Statistically significant differences between groups were identified by one-way ANOVA with Tukey's post hoc test. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 5 HGF induced an effective therapeutic effect against B16F10 tumor. a Schematic illustration of the experiment design to assess the tumor inhibition and the immune responses as triggered by PBS, HACA-Fe, HACA-GW, or HGF NPs on subcutaneous B16F10 tumor model. G1, PBS; G2, HACA-Fe; G3, HACA-GW; G4, HGF. b and c Tumor growth curves during treatment. d Survival rates of different groups over time. e and f Representative flow cytometry plots and quantification of e CD8 + f and CD4 + T cells after gating on CD45 + CD3 + T cells in tumor tissue. g and h Representative flow cytometric analysis of memory T cells (CD3 + CD8 + CD44 + CD62L - , gated on CD3 + CD8 + T cells) in the spleen. Data were presented as mean +- SD. n = 5 biologically independent animals per group. Statistically significant differences between groups were identified by one-way ANOVA with Tukey's post hoc test. * P < 0.05, ** P < 0.01, *** P < 0.001 and **** P < 0.0001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig6_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 6 In vivo therapeutic impetus of HGF to PD-L1 checkpoint inhibitor therapy. a Schematic illustration of the experiment design to assess the tumor inhibition and the immune responses as triggered by PBS, anti-PD-L1, HGF or HGF + anti-PD-L1 on subcutaneous B16F10 tumor model. G1, PBS; G2, anti-PD-L1; G3, HGF; G4, HGF + anti-PD-L1. b and c Tumor growth curves during treatment. d Survival rates of different groups over time. e - g Flow cytometric plots and quantification of e CD8 + and f CD3 + g T cells, among CD3 + T cells in the TDLN. h - m Flow cytometric quantification of GzmB + cells ( h - i ), Ki67 + cells ( j and k ) and Tim3 + cells ( l and m ) in CD8 + and CD4 + T cells. Data were presented as mean +- SD. n = 5 biologically independent animals per group. Statistically significant differences between groups were identified by one-way ANOVA with Tukey's post hoc test. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19043_41368_2021_136_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 5 P. gingivalis - and comDelta ppad -exacerbated UC is associated with an imbalance in Th17/Tregs. a , b Flow cytometric analysis and bar chart showing that compared with Delta ppad , P. gingivalis and comDelta ppad induced the transformation of CD4 + T cells into proinflammatory Th17 cells and simultaneously inhibited the generation of Tregs ( P < 0.05), but no difference was observed between mice administered Delta ppad and DSS and mice with colitis administered physiological saline ( P > 0.05). c ELISA showing that compared with Delta ppad , P. gingivalis and comDelta ppad administration caused the increased expression of IL-17 and decreased expression of IL-10 in serum ( P < 0.05). The expression levels of the two cytokines were similar in the mice administered Delta ppad and DSS mice and the mice with colitis ( P > 0.05). All indicators were measured with six replicates. The data are presented as the mean +- SD. * P < 0.05, ** P < 0.01, *** P < 0.000 1 by independent 2-tailed Student's t test and one-way ANOVA combined with Mann-Whitney U test</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19043_41368_2021_136_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 2 P. gingivalis -exacerbated UC is associated with an imbalance in Th17/Tregs. a , b Flow cytometric analysis and bar chart showing that compared with the NC group and the DSS group, P. gingivalis significantly induced the transformation of CD4 + T cells into proinflammatory Th17 cells ( P < 0.01) and inhibited the generation of Tregs ( P < 0.05). c ELISA showing that compared with the other two groups, P. gingivalis administration to mice with colitis significantly increased the expression level of IL-17 ( P < 0.01) and decreased expression of IL-10 in serum ( P < 0.05). All the indicators were measured in six replicates. The data are presented as the mean +- SD. * P < 0.05, ** P < 0.01, *** P < 0.000 1 by independent 2-tailed Student's t test and one-way ANOVA combined with Mann-Whitney U test</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14887_gr6.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 6 Assessments of organ damage and mouse metabolites during HLSA or recovery from HLSA. A , upper left panel , MMP-1, IL-1beta, and CRP levels in plasma had no significant change between the control group, HLSA group, and R-HLSA group. Upper right panel , CK-MB as a marker of heart injury in the plasma had no significant change between the control group, HLSA group, and R-HLSA group. Lower left panel , creatinine and BUN as markers of kidney injury in the plasma slightly increased in the HLSA group and returned to normal level after recovery from HLSA. Lower right panel , AST and ALT as markers of liver injury in the plasma showed no change between the control group, HLSA group, and R-HLSA group. Data were presented as mean +- SD (N = 6; ANOVA: ** p < 0.01). B , upper panel , food consumption and water consumption 3 days before and 3 days after a single ATP-induced HLSA depicted no change. Data were presented as mean +- SD (N = 6; ANOVA: p > 0.05). Lower panel , metabolomics analysis of scores plot from PCA analysis based on 1 H NMR data from the plasma, brain, liver, and kidney of the control group, HLSA group, and R-HLSA group. The PCA score showcased clusters correspond to metabolic patterns in different groups, with each point representing one sample. Circles represent 95% confidence interval for each score in each group (see also Figs. S5-S8 ). C , draining lymph nodes of mice that underwent HLSA once a day for 10 consecutive days were analyzed with FACS. CD44 and</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14881_thnov11p8570g006.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 6 mEVs restore DSS-disturbed balance between Treg and Th17 cells in the colonic lamina propria (LP). (A) mRNA expression of IL-10 in colon tissue (normalized to GAPDH). (B, C) Protein levels of cytokines IL-10 and IL-17A in colon tissue measured by ELISA. (D-F) Flow cytometry analysis of CD4 + CD25 + FoxP3 + Treg cells (D), IL-10 + FoxP3 + cells (E), and Th17 cells (F) in the colonic LP. (G) Expression of IL-23R protein in the colon. Data were presented as means +- SD. N = 4 to 5 mice per group. * p < 0.05, # p < 0.01.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14880_41419_2021_3874_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Levels of MDSCs in the heart are positively associated with age. A WGCNA of the coexpressed genes from 135 human whole blood transcriptomes from the GEO database (GSE123698). ME0 was related to age (correlation coefficient = 0.15) but not to sex (correlation coefficient = 0.043). Red indicates a positive correlation, and blue indicates a negative correlation. B Hypergeometric test of the genes in ME0 based on the immunologic gene set from GSE123698. The size of the dot represents the number of genes. A darker color indicates a lower correlation. C The bubble plots show the correlation between the G-MDSC/M-MDSC signature and age in males and females based on GSE123698. D The ratio (left) and signature value (right) of the G-MDSCs and M-MDSCs in 3-month-old and 16-month-old mice determined by scRNA-Seq analysis (GSE145477). E Representative flow cytometric profile showing the quantitative analysis of Cd11b + Gr1 + Ly6G+ cells and Cd11b + Gr1 + Ly6C+ cells in the hearts of young and aging mice; n = 5 per group. F CFSE-labeled CD4 + and CD8 + T cells and G-MDSCs separated from hearts were cocultured at a ratio of 2:1 for 24 h. Representative images and quantitative analysis of the proliferation of CD4 + or CD8 + T cells analyzed by flow cytometry; n = 6 per group. The data are presented as the means +- SDs. Differences were determined by Student's t test. * P < 0.05.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14876_fimmu-12-678999-g003.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 3 Expression of IDO1 leads to poor tumor infiltration by CD8+ T cells and increased infiltration of suppressive immune cells in the ovarian tumor microenvironment. (A) Frequency of CD8+ TILs on Days 28 and 57 from WT C57BL/6 (left panel n=6) and IDOKO (right panel n=6) mice challenged i.p. with 1x10e7 IE9mp1-mIDO1 or IE9mp1-EV tumor cells. (B) Immuno-stained IE9mp1-mIDO1 and IE9mp1-EV tumor from WT C57BL/6 mice on Day 48 with anti-IDO1 (green), CD8+ T cell (red), and DAPI (blue). Quantification of CD8+ T cells from 3 field images per tissue slide, (n=11 IE9mp1-EV and n=8 IE9mp1-mIDO1). Total original magnification is 63x. (C) Flow cytometry analysis of tumor ascites for CD4 + CD25 + FoxP3 + T cell frequency in IE9mp1-mIDO1 (n=7) and IE9mp1-EV (n=5) tumor-bearing WT C57BL/6 mice on Day 48. (D) Frequency of Ly6G+in CD11b + cell IE9mp1-EV (n=5) or IE9mp1-mIDO1 (n=5) tumor-bearing WT C57BL/6 mice on Day 28. *p < 0.05, **p < 0.01, using Student's t test (B-D) . The data represent means +- SEM of three independent experiments.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24718_pone.0251233.g002.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">10.1371/journal.pone.0251233.g002 Fig 2 Rora is expressed in activated T cells in vivo , with mainly spatial variation. (a) Experimental design for single-cell RT-qPCR. (b) Gene expression according to RT-qPCR from CD4+ T cells during N . brasiliensis infection. Gata3 hi cells, which we assume are Th2, are also expressing Rora . The category """"Cytokines"""" refers to any of Ifng , Il4 , Il13 , Il5 , Il6 , Il10 or Il17a being expressed. Top row denotes spatial location: Lung, gut (siLIP), mesenteric and mediastinal lymph nodes (n = 4 mice). Every column is one individual cell. (c) Flow cytometric analysis of CD4+ T cells from the spleen and lung of Rora +/teal naive mice (black histogram = Rora teal- cells, green histogram = Rora teal + cells) (n = 23). All error bars are +-sample s.d. (d) Frequency of Rora teal expression across tissues, with siLIP having the highest number (n = 12). (e) Fraction of naive (CD4+CD25-CD44-SELL+) or activated cells expressing Rora teal . RORA is mainly expressed in activated cells in vivo (n = 12) . (f) N . brasiliensis Rora expression over time, overlaid with previously published mouse and human in vitro time course data of Rora , showing no or low expression of Rora in activated in vitro T cells. (g) Experimental design of scRNA-seq experiment, with (h) tSNE clustering of CD4+ T cells extracted from N . brasiliensis infected mice and measured by single-cell RNA-seq (1670 cells after filtering). We primarily identify Naive, Th1, Th2 and Treg</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19041_JEM_20201763_FigS5.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure S5. Generation of T cell- or myeloid-specific PLCbeta4-deficient mice. (A and B) BMDM, CD4 + , or CD8 + T cells from WT, PLC4beta4 fl/fl , Lyz2-Cre/PLCbeta4 fl/fl , or Lck-Cre/PLCbeta4 fl/fl mice were lysed. PLCbeta4 protein levels in the indicated lysates were determined by Western blotting with indicated Abs. (C) WT or PLCbeta4-deficient mice ( n = 3 per group) were infected with 1 x 10 5 T. gondii . After 5 d, the percentages of CD69 + (left) and CD62L low (right) population on CD4 + T cells in the spleens from parasites infected WT or PLCbeta4-deficient mice were measured by flow cytometry. (D) WT or PLCbeta4-deficient mice ( n = 6 per group) were infected with 1 x 10 5 OVA expressing irradiated T. gondii . 14 d after infection, the percentages and cell numbers of OVA tetramer-positive CD4 + T cells in the spleens from parasite-infected WT or PLCbeta4-deficient mice were measured by flow cytometry. (E) Luciferase activities of serial dilutions of Pru expressing luciferase (10 3 -10 7 ) were plotted. A standard curve of luciferase activity (x axis) and parasite number (y axis) was generated by the data plots. Indicated values are means +- SD of three biological replicates (C). N.S., nonsignificant. Data are cumulative of three independent experiments (D) and representative of two (A, B) or three (E) independent experiments.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19041_JEM_20201763_FigS2.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure S2. PLCbeta4-deficient mice show intact T cell development and Th1 differentiation. (A) Percentages and cell numbers of CD4 - /CD8 - , CD4 + /CD8 - , CD4 - /CD8 + , and CD4 + /CD8 + in the thymocytes from WT or PLCbeta4-deficient mice were analyzed by flow cytometry. (B) Percentages and cell numbers of CD4 + and CD8 + T cells in the splenocytes from WT or PLCbeta4-deficient mice were analyzed by flow cytometry. (C) Naive CD4 + T cells from WT or PLCbeta4-deficient mice were cultured under Th1-polarizing conditions for 3 d. Frequencies of IFN-gamma producers were determined by intracellular staining using flow cytometry. Indicated values are means +- SD of three biological replicates (A-C). N.S., nonsignificant.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14878_cells-10-00978-g003.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 3 Biodistribution of virus following treatment. Immunocompromised NOG mice bearing bilateral HapT1 tumors were treated with i.t. injections of TILT-123 or PBS and i.v. injected with hamster TILs loaded with TILT-123 [TILs(TILT-123)], TILT-123, or PBS. DNA was extracted from day 4 snap-frozen ( A ) tumors and ( B ) livers and analyzed for the presence of virus DNA copies (E1A). The virus copy numbers were normalized to the amount of genomic DNA in the samples (GAPDH expression). ( C ) Tumors were collected, processed, and analyzed by flow cytometry for CD4 and CD8 positive cells. Dashed lines indicate the highest average background in control groups for CD8+ and CD4+ cells. Statistically significant differences were found by performing Kruskal Wallis test with Dunn's multiple comparison test. Only statistically significant differences are shown. Data is presented as mean + SEM; A--animal, T--tumor. *-- p < 0.05.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15116_fimmu-12-642420-g003.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 3 Paclitaxel dysregulates CD4 + and CD8 + T-cell subpopulations in an eIF4E-dependent manner. (A) Gating strategy used for flow cytometry of lymphocytes from popliteal and inguinal lymph nodes. T-cells were separated from the whole lymphoid cells population using CD3. CD3 + cells were then gated for CD4 + T-cell and CD8 + T-cells. For each of these subsets, cells were further gated for CCR7 or CD25 and CD44. (B) Quantification of CD4 + T-cells from the CD3 population from male mice. (C) CCR7 + T-cells from isolated CD4 + population in males, ** p 0.0063. (D) CD4 + cells gated for CD25 and/or CD44 in males. (E) Quantification of CD4 + T-cells from the CD3 + population from female mice, * p 0.0101. (F) CCR7 + T-cells from isolated CD4 + population in female mice, * p 0.0250. (G) CD4 + cells gated for CD25 and/or CD44 in female mice, ** p 0.0011. (H) Quantification of CD8 + T-cells from the CD3 + population from male mice. (I) CCR7 + T-cells from isolated CD8 + population in males, * p 0.0433. (J) CD8 + cells gated for CD25 and/or CD44 in males, * p 0.0396. (K) Quantification of CD8 + T-cells from the CD3 population from female mice, * p 0.041. (L) CCR7 + T-cells from isolated CD8 + population in female mice, ** p 0.0097. (M) CD8 + cells gated for CD25 and/or CD44 in female mice. All data are presented as mean +- standard error of the mean, n = 3 mice each for male/female WT vehicle-treated and WT paclitaxel groups, n = 4 mice each for male/female eIF4E S209A vehicle-trea</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14885_fcell-09-629306-g002.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">FIGURE 2 A high temperature environment changes the frequencies of Th1 and Th17 cells in the spleen and retinas of EAU mice (day 14 after IRBP immunization). (A) Representative flow cytometry and quantification of IFN-gamma+CD4 + T cells in splenic lymphocytes of EAU mice ( n normal temp = 10, n high temp = 11; mean +- SD; *** p < 0.001; Unpaired t -test). (B) Representative and quantification of IL-17A+CD4 + T cells in the splenic lymphocytes of EAU mice ( n normal temp = 10, n high temp = 11; mean +- SD; ** p < 0.01; Unpaired t -test). (C) The expression of IFN-gamma, IL-17A mRNA were detected by real-time qPCR in splenic lymphocytes from EAU mice housed under normal or high temperature conditions ( n = 5/group; mean +- SD; *** p < 0.001; Unpaired t -test). (D) The expression of IFN-gamma and IL-17A mRNA was detected by real-time qPCR in the retina from EAU mice ( n normal temp = 10; n high temp = 11; data were not normally distributed; median; ** p < 0.01, * p < 0.05; Differences were assessed by Mann Whitney test). (E) Weight of spleens were compared between EAU mice under high or normal temperature housing conditions ( n normal temp = 24, n high temp = 18; mean +- SD; *** p < 0.001; Differences were assessed by Unpaired t -test).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14849_ol-21-05-12670-g03.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 4. Vaccine-induced Th9 differentiation in vitro . Lymphocytes were isolated from the spleen and mesentery lymph nodes of C57/BL6 or ICR mice. Cells were then adjusted to a final density of 2.5x10 6 /ml in culture media, in the presence of 10 ng/ml IL-4 and 5 ng/ml TGF-beta, alone or in combination with 5 ug/ml Hepa1-6 or 10 ug/ml H22 vaccine. After 3 days of culture, the percentage of CD4 + IL-9 + Th9 cells was determined by FCM. Th0 cells were transformed into Th9 cells in the vaccine-only group or in the co-culture with TGF-beta and IL-4 groups. (A) FCM for Th9 cells in two HCC tumor-bearing mouse models. Statistical analysis for the (B) Hepa1-6/C57BL/6 and (C) H22/ICR models. *P<0.05 and **P<0.01. Cellular experiments were repeated >3 times. IL, interleukin; TGF, transforming growth factor; FCM, flow cytometry; Th, helper T; HCC, hepatocellular carcinoma; Ag, whole-cell antigen.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14884_ijms-22-02765-g003.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 3 Flow cytometric analysis of immune cell populations in the mesenteric lymph nodes (MLN) and spleen of normal and bleomycin (BLM) +- sodium butyrate (SB) mice. BLM was injected subcutaneously for two weeks. SB was administered orally from two weeks before BLM injection. Immune cells were then obtained from the MLN and spleen. ( A ) Flow cytometric gating strategy for macrophage and DC lineages. ( B ) Flow cytometry was used to assess total leukocytes (CD45 + ), macrophages (CD45 + CD64 + CD11b + CX 3 CR1 + ), DCs (CD45 + CD64 - CD11c + MHCII + ), B cells (B220+), and CD4+ T cells in MLN and spleen from normal and BLM +- SB mice. ( C ) Macrophage lineages were subdivided into phase 1 (P1: newly recruited monocytes), phase 2 (P2: maturing monocytes), and phase 3 (P3: monocyte/macrophage intermediates and resident macrophages) following developmental stages. Inflammatory monocytes were defined as both Ly6C + MHCII - (P1) and Ly6C + MHCII + (P2). Representative dot plots, percentages (gated on macrophage lineage) and absolute numbers of inflammatory monocytes are shown in the MLN (upper) and spleen (lower) from normal and BLM +- SB mice. Data are representative of two independent experiments with n = 4-5/group; each symbol represents one mouse. MHCII: Major histocompatibility complex class II. * p < 0.05, ** p < 0.01.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14820_etm-21-05-09914-g03.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 4 Flow cytometric analysis of Th17 cells. CD4-PC5, IL-17A-PC7 and isotype control antibodies were used to determine the proportion of Th17 lymphocytes. (A) Percentage of Th17 cells in WKY-C, WKY-M, and WKY-T groups. (B) Percentage of Th17 cells in week 16 was analyzed using one-way ANOVA with Tukey's post hoc test. Data are presented as the mean +- standard error of the mean. n=3/group. ** P<0.01 as indicated. C, control; M, methionine; T, treatment; WKY, Wistar-Kyoto; Th17, T helper cell 17.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14874_ADVS-8-2003338-g006.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 6 In vivo immunotherapy efficacy of Hb@Hf-Ce6 NPs mediated RT-RDT combined with anti-PD-1 antibody. a) Respective proportion of total macrophages (left column) and M2 phenotype macrophages (right column) in distant tumors. b) Respective proportion of CD4 + T cells (left column) and CD8 + T cells (right column) in distant tumors. c) Representative flow cytometry plots of CD4 + T cells and CD8 + T cells in distant tumors from six groups of mice. d) Respective proportion of regulatory T cells (CD3 + , CD4 + , Foxp3 + ) in distant tumors. e) Respective proportion of effector T cells (CD3 + , CD8 + , IFN gamma + ) in distant tumors. f) Respective proportion of memory T cells (CD3 + , CD8 + , CD62L low , CD44 high ) in spleen. g-k) Cytokine levels of TNF- alpha , IFN- gamma , IL-6, IL-12p70, and IL-10 in serum from mice after various treatments. l) Schematic showed the potential mechanism of Hb@Hf-Ce6 NPs mediated RT-RDT-Immunotherapy for immune response activation to inhibit both primary and distant tumors. Briefly, Hb@Hf-Ce6 NPs accumulated at the tumor site through blood circulation. After X-ray irradiation on the primary tumor, Hb@Hf-Ce6 NPs can not only enhance the RT effect but also activate Ce6 with the assistance of radioluminescence by RDT to generate more ROS. The necrosis tumors in situ activated adaptive and innate immunity and caused a significant proinflammatory response. Furthermore, the anti-PD-1 antibody enhanced the immune response. Activated immunotherapy</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14875_13287_2021_2159_Fig6_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 6 MiR-223 reduced donor T cell migration to recipient mice spleens. The proportion of H2kb + CD4 and CD8 T cell in recipient mice spleens on day 7 was assessed by flow cytometry. Compared with NC and aGvHD group, H2kb + CD4 and H2kb + CD8 cell percentages in miR-223 group showed significant reduction ( a ). The average number of H2kb + CD4 and H2kb + CD8 cells in miR-223 group showed significant decline ( b ). Data were presented as mean +- SEM. Measured in three independent experiments, n = 7 per group. * P < 0.05, ** P < 0.01</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9827_abe5819-F2.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 2 Vaccination with AMP-CpG elicits potent Spike RBD-specific CD8 and CD4 T cells in spleen and blood. C57BL/6 mice ( n = 10 per group) were immunized on days 0, 14, and 28 with 10 mug of Spike RBD protein admixed with 100 mug of alum or 1 nmol soluble CpG or AMP-CpG, and T cell responses were analyzed on day 35. ( A ) Splenocytes were restimulated with overlapping Spike RBD peptides and assayed for IFNgamma production by ELISpot assay. Shown are representative images of ELISpot and frequency of IFNgamma SFCs per 1 x 10 6 splenocytes. ( B and C ) Peripheral blood cells were restimulated with overlapping Spike RBD peptides and assayed by flow cytometry for intracellular cytokine production to detect antigen-specific T cell responses. Shown are frequencies of IFNgamma, TNFalpha, and double-positive T cells among (B) CD8 + and (C) CD4 + T cells, with corresponding representative flow cytometry plots. n = 10 mice per group. Values depicted are means +- standard deviation. ** P < 0.01; *** P < 0.001; **** P < 0.0001 by two-sided Mann-Whitney test applied to cytokine + T cell frequencies.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9827_abe5819-F3.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 3 Vaccination with AMP-CpG elicits potent lung Spike RBD-specific CD8 and CD4 T cells. C57BL/6 mice ( n = 10 per group) were immunized on days 0, 14, and 28 with 10 mug of Spike RBD protein admixed with 100 mug of alum or 1 nmol soluble CpG or AMP-CpG, and T cell responses were analyzed on day 35. ( A ) Cells collected from perfused lung tissue were restimulated with overlapping Spike RBD peptides and assayed for cytokine production to detect antigen-specific T cell responses. Shown are frequencies (means +- standard deviation) of IFNgamma, TNFalpha, and double-positive T cells among (A) CD8 + and ( B ) CD4 + T cells, with corresponding representative flow cytometry plots. ( C ) Cytokine concentration in supernatants from restimulated lung cells. n = 10 mice per group. Values depicted are means +- standard deviation. **** P < 0.0001 by two-sided Mann-Whitney test applied to cytokine + T cell frequencies or cytokine concentrations.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9826_jitc-2020-001932f01.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 1 The phosphotyrosine switch is important for host ERbeta to inhibit tumor growth. (A) Representative genotyping results for WT and mutant allele of WT and KI mice. (B) ERbeta protein levels in mouse bone marrow and spleen (Ponceau S shown as loading control). (C) M-Wnt mammary tumor growth in female WT/KI mice. (D) B16F10 (B16) melanoma growth in WT/KI male mice. (E-H) Flow cytometry of B16 melanoma-infiltrating percentage of CD3 + (of CD45 + ), (E), CD4 + (of CD45 + CD3 + ), (F), CD8 + (of CD45 + CD3 + ), (G), CD11c + (of CD45 + CD3 + ), (H). KI, knock-in; WT, wild-type.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0008.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 8. G6PD is required for HK2 stable expression and T cell functions. a-c , Whole-cell NADPH concentration ( a ), immunoblot ( b ), right panel in b is a summary graph of densitometric quantification of three independent experiments, and qRT-PCR ( c ) assays using total T cells isolated from wildtype ( G6pd WT ) or G6PD mut mice, in vitro activated with anti-CD3 plus anti-CD28 for 72 h ( a , b ) or as indicated ( c ) ( a , n=2 per genotype; c , n=4 per genotype). d , Immunoblot analysis using lysates of G6PD WT or G6PD mut T cells, stimulated with anti-CD3 plus anti-CD28 for 48 h in the presence (+) or absence (-) of NAM. Right panel is a summary graph of densitometric quantification of two independent experiments (n=4 per genotype). e , Immunoblot analysis using lysates of G6PD mut CD8 + T cells transduced with either a control vector or Flag-G6PD. f,g , Immunoblot ( f ) and flow cytometric analysis of ROS level ( g ) using total T cells isolated from chimeric mice transferred with G6PD WT or G6PD mut bone marrows, in vitro activated with anti-CD3 plus anti-CD28 for 48 h. h , Flow cytometric analysis of CD4 + and CD8 + T cells in the spleen of G6PD WT and G6PD mut mice. i , ELISA of IFN-gamma and IL-2 in the supernatant of G6PD WT and G6PD mut CD8 + T cell cultures stimulated with anti-CD3 plus anti-CD28 for 66 h. j , CoIP analysis of endogenous NIK-G6PD interaction using whole-cell lysates of CD8 + T cells isolated from NIK iTg mice and activated for 48 h with anti-CD3</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0001.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 1. T cell-specific deletion of NIK impairs antitumor immunity. a, Tumor growth curve of Map3k14 tKO (tKO) and wildtype (WT) control mice injected s.c. with 2 x 10 5 B16F10 melanoma cells. b , c , Flow cytometric analysis of the frequency and absolute cell number of CD4 + and CD8 + T cells ( b ) and IFN-gamma-producing CD8 + effector T cells ( c ) in the tumor of day16 B16F10-implanted Map3k14 tKO and wildtype mice ( b , c , n=6 per genotype). d - f , Flow cytometric analysis of the frequency and absolute number of CD4 + and CD8 + T cells in the draining lymph node ( d ), CD44 + CXCR3 + CD8 + effector T cells in the draining lymph node ( e ), and CD44 + CXCR3 + CD8 + effector T cells in the tumor ( f ) of day16 B16F10-implanted Map3k14 tKO and wildtype control mice ( d , n=6 per genotype; e , f , n=5 per genotype). g , Flow cytometrc analysis of tumor-infiltrating wildtype and Map3k14 tKO OT-I CD8 + T cells in B16-OVA-tumor bearing B6 mice adoptively transferred (on day 17) with a mixture (1:1 ratio) of in vitro activated wildtype (CMTMR labeled) and Map3k14 tKO (CFSE labeled) OT-I CD8 + T cells (n=6 per group). h , i , Flow cytometric analysis of apoptosis based on caspase 3 cleavage ( h ) and proliferation based on CFSE dilution ( i ) of tumor-infiltrating wildtype and Map3k14 tKO OT-I CD8 + T cells in B16-OVA-tumor bearing B6.SJL mice adoptively transferred on day 14 with in vitro activated and CFSE-labeled wildtype and Map3k14 tKO CD8 + T cells for 7 days; n=3 per g</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0002.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 2. Ectopic expression of NIK prevents T cell exhaustion and promotes antitumor immunity. a-c , Tumor growth curve ( a ), image of day 32 tumors ( b ), and survival curve ( c ) of the MC38-bearing NIK iTg and wildtype control mice. d , e , Tumor growth ( d ) and survival ( e ) curves of NIK iTg and wildtype control mice injected s.c. with 5 x 10 5 B16F10 melanoma cells. f , g , Flow cytometric analysis of the frequency and absolute cell number of CD4 + and CD8 + T cells ( f ) and IFN-gamma-producing CD8 + effector T cells ( g ) in day-32 tumor of MC38-bearing NIK iTg and wildtype control mice ( f , g , n=6 per genotype). h-j , Flow cytometric analysis of the frequency and absolute cell number of CD4 + and CD8 + T cells in the draining lymph node ( h ) and CD44 + CXCR3 + CD8 + effector T cells in the draining lymph node ( i ) or tumor ( j ) of day-32 MC38-implanted NIK iTg and wildtype control mice ( h , n=6 per group; i , n=4 per group; j , n=3 per group). k , l , Flow cytometric analysis of the frequency and absolute cell number of PD1 + Tim3 + and PD1 + Tim3 - CD8 + T cells ( k ) and IFN-gamma-producing gated PD1 + Tim3 + CD8 + T cells ( l ) in day-32 tumor of the MC38-bearing wildtype or iTg mice ( k , l , n=6 per genotype). m , n , Flow cytometry ( m ) and qRT-PCR ( n ) analyses of PD1 and Tim3 expression level in tumor-infiltrating PD1 + Tim3 + CD8 + T cells of MC38-bearing (day 32) wildtype or iTg mice ( n , WT: n=2; NIK iTg : n=3) . o , Schematic of experimental</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0009.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Extended Data Fig. 1 NIK regulates T cell exhaustion and antitumor immunity a, genotyping PCR of R26Stop FL Map3k14 (Map3k14 Tg ), Map3k14 +/+ CreER, and R26Stop FL Map3k14 -CreER ( Map3k14 Tg CreER) mice, showing the PCR products of NIK-GFP in Map3k14 Tg allele and CreER. b, Immunoblot analysis of NIK expression in tamoxifen-treated Map3k14 +/+ CreER (WT) and Map3k14 Tg CreER (iTg) mice. c, Schematic of experimental design for producing B16F10 tumor-bearing NIK iTg and WT control mice. Each mouse was injected s.c. with 5 x 10 5 B16F10 cells (WT=9, iTg=7). d,e, Flow cytometric analysis of the frequency and absolute cell number of CD4 and CD8 T cells in the tumor (d) or draining lymph node (e) of day 18 B16F10 tumor-implanted NIK-iTg and WT mice ( d , WT: n=4; iTg: n=5; e , n=6 per genotype). f,g, Flow cytometric analysis of the frequency and absolute number of CD44 + CXCR3 + CD8 effector T cells in the draining lymph node ( f ) or tumor ( g ) of day 18 B16F10 tumor-implanted NIK-iTg and wildtype mice ( f , n=6 per genotype; g, n=4 per genotype). h,i, Flow cytometric analysis of the frequency and absolute number of PD1 + Tim3 + CD8 + T cells ( h ) or IFNgamma-producing PD1 + Tim3 + CD8 T cells ( i ) in the tumor of day 18 B16F10-implanted NIK iTg and wildtype control mice (h,i, n=4 per genotype). Data are representative of three independent experiments. Summary data are shown as mean +- s.e.m. with P values determined by two-tailed Student's t test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0005.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 5. HK2 is required for antitumor immunity. a , b , Tumor growth ( a ) and survival ( b ) curves of Hk2 tKO or wildtype (WT) control mice injected s.c. with 10 5 B16F10 melanoma cells for the indicated time periods. c , d , Flow cytometric analysis of the frequency and absolute number of CD4 + and CD8 + T cells ( c ) and IFN-gamma-producing CD8 + effector T cells ( d ) in day 20 tumor of the B16F10-implanted Hk2 tKO and wildtype control mice ( c ,WT: n=9; Hk2 tKO : n=8; d , n=5 per genotype). e , Tumor growth curve of MC38 tumor-bearing wildtype, NIK iTg (iTg), and NIK iTg Hk2 iKO (iTg-iKO) mice. f,g, Flow cytometric analysis of the frequency and absolute cell number of IFN-gamma-producing CD8 + T cells ( f ) and gated PD1 + Tim3 + CD8 + T cells ( g ) in day-27 tumor of the MC38 tumor-bearing mice ( f , g , WT: n=4, iTg: n=4, iTg-iKO: n=3) . Data are representative of two ( e-g ) or three ( a-d ) independent experiments. Flow cytometry data are presented as representative plots (left) and summary graphs (mean +- s.e.m.) based on multiple mice (right, each circle represents an individual mouse). P values were determined by two-way analysis of ANOVA with Bonferroni correction ( a , e ), two-tailed Student's t test ( c , d , f,g ) or two sided log- rank test ( b ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0006.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 6. HK2 deletion blocks the autoimmune phenotype of NIK tTg mice. a, Body weight of 36-day old wildtype (WT), NIK tTg (tTg), and NIK tTg Hk tKO (tTg-tKO) littermate mice (WT: n=5, tTg: n=8, tTg-tKO: n=7) . b , Image of inguinal lymph nodes and thymi of four pairs of mice with the indicated genotypes. c , H&E staining of colon and lung sections from moribund NIK tTg , NIK tTg Hk tKO and age-matched littermate wildtype control mice were assessed for leukocyte infiltrates by hematoxylin-eosin stain. Scale bars: 100 mum. (n=3 in each group). d-g , Flow cytometric analysis of the frequency and absolute cell number of double-negative (DN), double-positive (DP), CD8 + single-positive (SP), and CD4 + SP thymocytes ( d ), thymic CD25 + foxp3 + T reg cells ( e ), lymph node CD25 + foxp3 + T reg cells ( f ), and lymph node CD44 - foxp3 + T reg cells ( g ) in NIK tTg , NIK tTg Hk tKO or wildtype mice ( e-f , NIK iTg : n=6, NIK tTg Hk tKO : n=4, wildtype: n=5). Data are representative of two ( a-c , e-g ) or three ( d ) independent experiments. Summary data are shown as mean +- s.e.m. with P values determined by two-tailed Student's t test ( a , d-g ) .</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0013.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Extended Data Fig. 5 NIK-mediated stimulation of antitumor T cell responses requires HK2 Flow cytometric analysis of the frequency and absolute cell number of CD4 and CD8 T cells ( a ), PD1 + Tim3 + CD8 T cells ( b ) and flow cytometric analysis of the expression level (MFI) of PD1 and Tim3 in CD8 T cells ( c ) in day-27 tumor of wildtype (WT), NIK iTg (iTg), NIK iTg Hk2 iKO (iTg-iKO) mice injected s.c. with 5 x 10 5 /mouse MC38 colon cancer cells ( a,b, WT: n=4; iTg: n=4; iTg-iKO: n=3). Data are representative of two independent experiments. Summary data are shown as mean +- s.e.m. with P values were determined by two-tailed Student's t test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15659_ppat.1009136.g010.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">10.1371/journal.ppat.1009136.g010 Fig 10 SAG-induced Runx-dependent CD40 upregulation on DCs promotes type-1 T cell response in LD-infected mice. Runx1- and Runx3-silenced BMDCs (with or without CD40 overexpression), and control-silenced BMDCs were treated with SAG and then adoptively transferred into LD-infected mice. Alternatively, age-matched uninfected and LD-infected mice were left without any DC transfer (details given in Fig 9 legend). (A and B) Frequency of IFNgamma- and IL-10-producing CD4 + (A) or CD8 + (B) T cells in splenocytes isolated from these mice, assessed by flow cytometry (representative data of n = 6). Numbers indicate the percentage of cells in the respective quadrants. Gating strategy used for flow cytometry analysis is described in S19 Fig . (C) Graphs displaying cumulative data of the percentage of IFNgamma- and IL-10-producing CD4 + (upper panels) or CD8 + (lower panels) T cells from two independent experiments ( n = 3 mice per group in each experiment). Each symbol represents an individual mouse; horizontal bars represent the mean. In all experiments, LD strain AG83 was used. * p < 0.001, ** p < 0.01, *** p < 0.05; NS, not significant.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14883_gr2.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 2 NK Cells Contribute to Both Innate and Adaptive Immune Control of Ptgs -/- Tumors (A) Growth profile of Ptgs +/+ and Ptgs -/- melanoma cells implanted into Rag1 -/- or wild-type mice untreated or depleted of NK, CD4 + , and/or CD8 + cells. (B and C) Frequency of CD8 + T cells (B); representative plots and frequency of CD8 + CD44 + , CD8 + IFNgamma + , and CD4 + IFNgamma + T cells (C) gated on live, CD45 + , CD3epsilon + cells in Ptgs +/+ and Ptgs -/- untreated or NK cell-depleted wild-type mice analyzed 7 days post-implantation. (D) Individual growth profiles of Ptgs -/- melanoma cells in wild-type mice depleted of NK cells from the day before or a week after cancer cell implantation. (E) Growth profile of Ptgs +/+ and Ptgs -/- cells in wild-type mice or Ptgs +/+ cells in GPP mice. (F) Tumor weight, NK cell frequency, and number per g of tumor analyzed 4 days after implantation of Ptgs +/+ and Ptgs -/- cells in wild-type or Ptgs +/+ cells in GPP mice. (G) Growth profile of Ptgs +/+ and Ptgs -/- melanoma cells in wild-type or Ptgs +/+ melanoma cells in Ptger2 -/- or Gzmb-Cre Ptger4 floxed/floxed mice. Data are expressed as mean +- SEM, one-way (B-C and F) or two-way ANOVA (A).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8286_jcmm15942-fig-0002.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">2 FIGURE Effects of DTA-64 inflammatory cells infiltration and NF-kappaB signalling pathway in the lung. (A) H&E staining for inflammatory cell infiltration (x200 magnification, scale bar: 5mum). (B) The gating strategy of total cells, eosinophils and neutrophils in the BALF. Granulocytes in the BALF were gated based on the CD45.2 + properties. Within the CD45.2 gate, CD45.2+/CD11b+/ly6G+, CD45.2+/Siglec-F + cells and CD3e+/CD4+ cells represented the eosinophils, neutrophils and T cells, respectively. (C) The numbers of total cells, eosinophil (EOS), neutrophil (Neu) and T cells (Lym). (D) The production of NF-kappaB p65 (nuclear), NF-kappaB (cytosol), p-IkappaBalpha and IkappaBalpha in the lung homogenates was estimated by western blotting, and the relative density (E) was measured. (F) Immunofluorescence assay for NF-kappaB p65 in the lung sections was performed. All data were shown as mean +- SD (n = 3). * P < 0.05, ** P < 0.01 vs control group. # P < 0.05, ## P < 0.01 vs OVA group</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8286_jcmm15942-fig-0003.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">3 FIGURE Effects of DTA-64 on the Th1/Th2/Th17 balance in vivo. Flow cytometric analysis of CD4 + T cell and Th1/Th2/Th17 subtypes was performed in BAL cells, mLNs and splenocytes. (A) CD3e+/CD4+ cells in the BAL cells, mLNs and splenocytes were selected. (B) Proportion of CD3e+/CD4+ cells was displayed by histogram. (C) Th1/Th2/Th17 cytokines within the CD3e+ CD4+ cells in the BAL cells were selected. (D) Levels of IL-4, IL-17 or IFN-gamma secreting cells within the CD3e+/CD4+ cells were shown by histogram. (E) Production of IL-4, IL-17 and IFN-gamma was measured by ELISA. (F) The photograph of mLNs in the group mice. Arrows indicate the mLN. (G) Proportion of IL-4, IL-17 and IFN-gamma-positive cells in the CD3e+/CD4+ cells were displayed by histogram. All data were shown as mean +- SD * P < 0.05, ** P < 0.01 vs control group. # P < .05, ## P < 0.01 vs OVA group</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14882_cells-09-02068-g001.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 1 Truncated PPM1D impairs DNA damage response in mouse thymus. Expression of PPM1D mRNA was analyzed by RT-qPCR in the thymi of Ppm1d +/+ , Ppm1d T/+ and Ppm1d T/T mice and was normalized to GAPDH ( n = 3) ( A ). Thymi from mice of indicated genotypes were lysed and proteins were separated by SDS-PAGE. Samples were probed with antibody against PPM1D and importin-beta as a loading control. The empty and full arrowheads indicate the position of the full-length and the C-terminally truncated PPM1D, respectively. ( B ). Cells from thymi from Ppm1d +/+ and Ppm1d T/+ mice were analyzed by flow cytometry. Plotted are the counts of the indicated populations as follows: double-negative T-cells (DN and DN1, DN2, DN3, DN4), double-positive T-cells (DP), CD8-positive T-cells (CD8+) and CD4-positive T-cells (CD4+) ( n = 3) ( C ). The median size of the thymus was determined in Ppm1d +/+ ( n = 11) and Ppm1d T/+ ( n = 12) mice ( D ). A scheme of the experimental setup in F-I. Mice were exposed or not to a low dose of IR (3 Gy), sacrificed after 6 h and thymi and lymph nodes were collected ( E ). Proteins isolated from thymi from mice of indicated genotypes exposed to mock or to IR were probed with the indicated antibodies by immunoblotting ( F ). Proteins isolated from inguinal lymph nodes from mice of indicated genotypes exposed to mock or to IR were probed with the indicated antibodies by immunoblotting ( G ). RNA isolated from thymi from mice in E was analyzed by RT-qPCR. The expr</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24327_NeuralRegenRes_2021_16_2_382_290910_f3.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 3 T-cell subsets derived from splenocytes using flow cytometric analysis during the 14 days after spinal cord injury. (A, B) Percentage of gated CD4 + T-cells, following stimulation, compared with the unstimulated control. (C) Percentage of CD4 + IFN-gamma + T-helper cells, in response to stimulation. CD4 + IFN-gamma + T-cells in the spleen demonstrated a sharp decline within 3-7 days after surgery. (D) Percentage of CD4 + IL17A + T-helper cells in response to stimulation. The percentage of CD4 + IL17A + T-cells increased 7 days after surgery. (E) Percentage of CD4 + IFN-gamma + IL17A + T-cells, in response to stimulation. (F, H) Percentage of gated CD4 + T-cells, compared with control. (G) Percentage of CD4 + CD25 + FoxP3 + regulatory T-cells. Regulatory T-cell numbers presented a sharp increase in the spleen 3 days post-injury, and then gradually declined. Data are expressed as the mean +- SEM ( n = 6; one-way analysis of variance followed by Tukey's post hoc test). * P < 0.05, ** P < 0.01, *** P < 0.001. FoxP3: Forkhead box P3; FSC: forward scatter; IFN-gamma: interferon-gamma; IL17A: interleukin 17A; SSC: side scatter. Figure 3</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19040_NRR-16-382-g004.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 3 T-cell subsets derived from splenocytes using flow cytometric analysis during the 14 days after spinal cord injury. (A, B) Percentage of gated CD4 + T-cells, following stimulation, compared with the unstimulated control. (C) Percentage of CD4 + IFN-gamma + T-helper cells, in response to stimulation. CD4 + IFN-gamma + T-cells in the spleen demonstrated a sharp decline within 3-7 days after surgery. (D) Percentage of CD4 + IL17A + T-helper cells in response to stimulation. The percentage of CD4 + IL17A + T-cells increased 7 days after surgery. (E) Percentage of CD4 + IFN-gamma + IL17A + T-cells, in response to stimulation. (F, H) Percentage of gated CD4 + T-cells, compared with control. (G) Percentage of CD4 + CD25 + FoxP3 + regulatory T-cells. Regulatory T-cell numbers presented a sharp increase in the spleen 3 days post-injury, and then gradually declined. Data are expressed as the mean +- SEM ( n = 6; one-way analysis of variance followed by Tukey's post hoc test). * P < 0.05, ** P < 0.01, *** P < 0.001. FoxP3: Forkhead box P3; FSC: forward scatter; IFN-gamma: interferon-gamma; IL17A: interleukin 17A; SSC: side scatter.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14877_hum.2020.050_figure5.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 5. Increased tumor-infiltrating T cell populations upon treatment with KLS-3010. Tumor-infiltrating T cells were analyzed on day 5 postadministration. The percentages of CD8 + (A) , CD8 + IFN-gamma + (B) , CD4 + (C) , CD4 + IFN-gamma + (D) , and regulatory (E) T cells were determined by flow cytometry. Data are shown as mean +- standard error ( n = 5 mice/group). * p < 0.05.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9817_jciinsight-5-136773-g165.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 1 Lymphocytes make up the main immune population within digested GCT. Viable single tumor cell suspension and PBMCs from healthy donors were analyzed using polychromatic flow cytometry and progressive gating strategy. ( A ) Representative staining with CD3, CD4, CD8, CD25, CD45, and FOXP3 used to quantify helper (CD4 + ), cytotoxic (CD8 + ), and regulatory (Tregs) (CD4 + CD25 + FOXP3 + ) T cells in a GCT sample. ( B-D ) Representative staining with CD11b, HLA-DR, CD11c, Lineage, CD14, CD15, and CD33 used to identify the myeloid populations in a GCT sample. Tumor-associated macrophages (TAMs)/monocytes were separated from DC based on CD14 expression ( C ). Myeloid-derived suppressor cells (MDSC) were separated as eMDSC based on Lineage, HLA-DR, CD11b, and CD33 markers ( B ), whereas PMN-MDSC were characterized as CD15 + CD14 - CD11b + ( D ). Proportions of tumor-infiltrating immune cells in GCT were quantified as percentage of total cell suspension. ( E ) Percentages of CD4 + T cells, CD8 + T cells, and Tregs compared with total tumor cell suspension. ( F ) Comparison of PD1-expressing T cells in the GCT vs. PBMCs. ( G ) CD8 + T cells/Tregs ratio in GCT vs. PBMCs. ( H ) Percentage of TAMs/monocytes, DC, PMN-MDSC, and eMDSC of total tumor cell suspension. Mean +- SEM is shown. Each dot represents a patient ( n = 7) or healthy control PBMCs ( n = 3).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9817_jciinsight-5-136773-g170.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 6 Vaccination with FoxL2-TT reduced tumor progression. ( A ) Healthy organs and tissues were collected from 3 mice, pooled together. RNA was extracted using Trizol, and foxl2 fold expression was calculated by real-time PCR. Mean +- SEM is shown. ( B and C ) T cells from FVB and BALB/c vaccinated mice were cocultured with BR5-FOXL2 and BR5 WT ( B ) and with IFN-gamma-pretreated 4T1-FOXL2 and 4T1 WT ( C ). ( D and F ) FVB and BALB/c were injected s.c. with 1 x 10 6 BR5-FOXL2 ( D ) and 2.5 x 10 5 4T1-FOXL2 ( F ) and, 3 days later, injected 3 times with FoxL2-TT or empty pVAX (CTRL) vaccines followed by electroporation. Data are shown as mean +- SEM ( n = 8-10 mice per group) from 1 of 3 experiments. Two-way ANOVA analyses were performed for tumor growth experiments. Percentage of tumor-infiltrating CD8 + and CD4 + T cells were calculated by flow cytometry at day 25. ( E and G ) Each dot represents a mouse, n = 6-3 mice per group ( E ) and n = 5 mice per group ( G ). Mean +- SEM is shown. Two-tailed t test analyses were performed. * P < 0.05, ** P < 0.01.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19039_nn0c03438_0003.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 3 Effect of GO on spleen function, after 24 h and one month postinjection of GO at different concentrations (2.5, 5, 10 mg/mL) compared with control mice, Dex 5% (negative control), and LPS 5 mg/kg-injected (positive control) mice. (a) Blood smears stained with H & E at two magnifications, 60x (scale bar 50 mum) and inset images 300x (scale bar 5 mum). The graph represents the percentage of deviant RBCs (reticulocytes, abnormal and aged RBCs) from the total RBC counts; the black arrows indicate some of the deviant RBCs detected in LPS-injected mice. The graph was obtained after counting >500 cells from each mouse ( n = 3 per group). (b) Pearls' Persian blue-stained spleen tissue sections (5 mum thick) at two magnifications, 20x (scale bar, 100 mum) and inset images 100x (scale bar, 20 mum). Blue spots demonstrate regions of Persian blue-stained hemosiderin. The graph represents the percentage of total imaged tissue that stained blue, indicating the presence of hemosiderin. This was obtained by measuring the intensity of the blue-stained regions from 3 or 4 images from each mouse captured at 20x ( n = 3, 4 mice per group) by Fuji Image J analysis. (c) Spleen T-lymphocyte cell counts, CD4 + T-helper cell counts plot (left), and cytotoxic CD8 + cell count plot (right). Cell counting was performed by flow cytometry. Three repeat counts were performed for each group of mice ( n = 3). (d) Gene expression levels of pro-inflammatory cytokines IL-6, IL-1beta, and TNF-alpha and</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12504_ijbsv16p2072g002.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 2 Th1/Th2/Th17/Treg cell subset distribution in lungs of mice. The single-cell suspensions of lungs in mice were detected for Th1/Th2/Th17/Treg cell subsets by flow cytometry. (A) CD4 + IFN-gamma + Th1 cells, (B) Th1 cell percentage, (C) Absolute number of Th1 cells, (D) CD4 + IL-4 + Th2 cells, (E) Th2 cell percentage, (F) Absolute number of Th2 cells, (G) CD4 + IL-17 + Th17 cells, (H) Th17 cell percentage, (I) Absolute number of Th17 cells, (J) CD4 + CD25 + Foxp3 + Treg cells, (K) Treg cell percentage, and (L) absolute number of Treg cells each group are shown. The values are mean+-SEM of 12 mice from two independent experiments. * P < 0.05, ** P < 0.01, *** P < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_10032_ijms-21-04169-g006.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 6 Flow cytometry for immune cells in the drainage lymph nodes (DLNs). ( A ) In DLNs, the percentage of CD8 + IFNgamma + T cells was higher in 1Y-old mice than in 8W-old mice ( p = 0.032; Kruskal-Wallis test followed by Dunn's post hoc test). The percentages of CD8 + IL-17A + , CD4 + IFN-gamma + , and CD4 + IL-17A + T cells in 2Y-old mice were significantly higher than in the other groups (one-way ANOVA). ( B ) The percentages of CD11b + CD86 + and CD11b + MHCII + Ly6C + cells were significantly higher in 2Y-old mice than in the other groups in the DLNs (one-way ANOVA). Red boxes indicate CD11b + MHCII + Ly6C + cells. n = 15, 8, and 3 for 8W-, 1Y-, and 2Y-old mice, respectively. * p < 0.05 and **** p < 0.0001. Data are presented as means +- standard error.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9821_jcav11p4059g006.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 6 The proportion of MDSCs and M1/M2 macrophage were changed by CG-745 treatment in Hepa1-6 syngeneic mouse model: (A-C) Hepa1-6 inoculated C57BL/6 mice were treated with vehicle or 15 mg/kg/day of CG (CG-745) by intraperitoneally for 5 days/week for 3 weeks. Tumor (A, B) and spleen (C) were harvested from each individual mouse. Cells were stained with fluorescence-conjugated antibodies specific to CD3, CD4, CD8, CD25 and Foxp3, and subjected to flow cytometry analysis. The graph shows means with error bars. Error bars represent standard deviations for 3 samples in each group. Results are representative of three separate experiments (A). p < 0.05.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12503_42003_2020_916_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 5 The synergistic anti-tumor effect of tankyrase and PD-1 inhibition is recapitulated by beta-catenin depletion in tumor cells and is dependent on IFNgamma and CD8 + T cells. a , B16-F10 Ctnnb1 KO tumor (s.c.) end volume reduction upon anti-PD-1 (-78%) and combined anti-PD-1/G007-LK treatment (-90%) in C57BL/6 N mice treated from day 11 through day 25. Control diet ( n = 9), G007-LK diet ( n = 9), anti-PD-1 ( n = 10), and anti-PD-1/G007-LK ( n = 10). Mann-Whitney rank sum tests are indicated by + ( P < 0.05) and ++ ( P < 0.01). For a - e Mean values are indicated by grey lines. b Tumor end volumes of B16-F10-challenged (s.c.) C57BL/6 Rag2 -/- mice treated for 12 days with control diet ( n = 11) compared to combined anti-PD-1/G007-LK treatment ( n = 10). n.s. not sig n ificant. c B16-F10 tumor (s.c.) end volume reduction upon anti-PD-1/G007-LK treatment in C57BL/6 N mice from day 10 through day 21. Control diet ( n = 11), anti-IgG1 isotype control ( n = 12), anti-IgG2 isotype control ( n = 10), anti-CD8alpha ( n = 10), anti-IFNgamma ( n = 9), anti-PD-1/G007-LK ( n = 10), anti-PD-1/G007-LK /anti-CD8alpha ( n = 9), and anti-PD-1/G007-LK /anti-IFNgamma ( n = 9). One-tailed t -tests are indicated by *( P <= 0.05) while one-tailed Mann-Whitney rank sum test is indicated by + ( P < 0.05). d Flow cytometry analysis of CD8 + and CD4 + T cells (shown as % of CD45 + T cells) from single-cell suspensions of comparable-sized tumors collected from B16-F10-challenged (s.c.) C57BL/6 N m</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_13456_41419_2020_2489_Fig4_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 4 Responses of the ocular surface, lacrimal gland, and DLN to desiccating injury in Fut1 KO and WT C57BL/6 mice. a Illustration of dry chamber with a fan and dehumidifier for induction of desiccation injury and experimental scheme. The 35-week-old mice were placed in a dry chamber for 10 consecutive days with intraperitoneal scopolamine injection three times a day. Ten days after injury initiation, the ocular surface, lacrimal glands, and DLN were assayed. b A circle in the photograph depicts the area of corneal opacity observed in Fut1 KO mice after desiccating injury. c Quantification of corneal stromal opacity using the standardized grading system. d The transcript levels of inflammatory cytokines in the ocular surface and intraorbital lacrimal gland as determined by real-time RT-PCR. Shown are the relative mRNA levels of each cytokine in Fut1 KO mice to the levels in WT mice. e Hematoxylin-eosin staining and CD3 immunostaining of the intraorbital lacrimal gland after injury (Scale bar, 200 mum). Neutrophil staining of the cornea with anti-neutrophil elastase Ab. Scale bars: 100 mum. f Representative and quantitative flow cytometry results for IFN-gamma + CD4 + and IL-17 + CD4 + cells in DLN from Fut1 KO and WT mice before and after desiccating stress. The percentage of CD4 + , IFN-gamma + CD4 + or IL-17 + CD4 + cells out of total DLN cells is shown, and a dot represents data from a single individual animal. Bar depicts mean +- SEM. * p < 0.05, ** p < 0.01, *** p < 0.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_13456_41419_2020_2489_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 3 Inflammatory response in the ocular surface, lacrimal glands, and ocular draining cervical lymph nodes (DLN) in Fut1 KO vs WT C57BL/6 mice. a-c Real-time RT-PCR analysis for mRNA levels of TNF-alpha, IL-1beta, and IFN-gamma in the ocular surface (cornea and conjunctiva), extraorbital and intraorbital lacrimal glands. Data are shown as the relative values of mRNA levels in Fut1 KO mice to those in WT mice. d CD3 immunostaining of extraorbital and intraorbital lacrimal glands (Scale bar, 200 mum) and neutrophil staining of the cornea (Scale bar, 100 mum). e Representative and quantitative flow cytometry results for IFN-gamma + CD4 + cells and IL-17 + CD4 + cells in DLN. The percentage of CD4 + , IFN-gamma + CD4 + or IL-17 + CD4 + cells out of total DLN cells is shown, and a dot depicts data from an individual mouse. Data are presented as mean +- SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, ns: not significant. Student's t -test (IL-1beta in a , c , e ) and Mann-Whitney U test (TNF-alpha in A, and IFN-gamma in B) were performed for statistical analysis.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14872_MMR-21-04-1789-g02.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 3. Expansion of the CD4 + CD25 + T-cell population is driven by combined treatment with PD-L1 Ig and anti-CD40L mAbs in the CBA/J x DBA/2 model. (A) Number of CD4 + CD25 + T cells in splenocytes was determined by flow cytometry. (B) Gating strategy used for flow cytometry, using the FSC/SSC method. R1 represents the T lymphocyte population. (C) Percentage of CD4 + CD25 + T cells. ***P<0.001 vs. the normal group (CBA/J x BALB/c). ### P<0.001 vs. the spontaneous abortion group (CBA/J x DBA/2); &&& P<0.001 vs. PD-L1 Ig + CD40L mAb group. PD-L1, programmed death-ligand 1; Ig, immunoglobulin; CD40L, CD40 ligand; mAb, monoclonal antibody; FSC, forward scatter; SSC, side scatter; PE, phycoerythrin.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12427_ADVS-7-1903301-g005.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 5 Immune stimulation ability and therapeutic efficacy of mini DC in tumor-bearing mice. A) Schematic diagram for the therapeutic regimen of mini DC in tumor-bearing mice. The mice inoculated with ID8 mouse ovarian cancer cells subcutaneous (s.c.) received six doses of various vaccine formulations, and tumor growth was measured over time ( n = 5 biologically independent animals in each group). B) Average and C) individual tumor growth curves as well as D) the digital tumor mass images of tumor-bearing mice treated with indicated vaccine regimens. When the tumor area of the control group exceeds 200 mm 2 , mice were sacrificed, and tumors and spleens were collected for section and analysis of the immune cell profile. E) Representative immunofluorescence staining images of tumor sections from different groups. Green represents CD3 and red represents CD8. Scale bar: 50 um. F) Representative flow cytometry contour plots of CD8 + CD3 + T eff and G) Foxp3 + CD4 + T reg in the spleens of tumor-bearing mice at the end of the study. Data in panel (B) show mean +- SD and were analyzed by two-way ANOVA with Tukey''s multiple comparisons test. **** p < 0.0001 and ** p < 0.01.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12427_ADVS-7-1903301-g004.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 4 In vivo activation of T cells by mini DC. A) Representative flow cytometry scatter plots and D) frequency of CD3 + CD8 + T cells in dLNs of mice 3 days after immunization with six dosages of PBS, ID8 lysate, PLGA-NP, BMDC, or mini DC ( n = 5 biologically independent animals in each group). Flow cytometry analysis and percentage of B,E) IFN-gamma + CD8 + effector T cells and C,F) Foxp3 + CD25 + CD4 + regulatory T cells isolated from spleens of mice receiving different vaccinations. G) IFN-gamma and H) TNF-alpha levels in serum of immunized mice measured by ELISA. I) Ex vivo cytotoxicity of CD8 + T cells isolated from spleens of immunized mice 3 days after vaccination with different vaccine formulations ( n = 4). CD8 + T cells (effector cell) and ID8 cells (target cell) were cocultured at ratios of 20:1 and 10:1 (E:T) for 10 h. In panels (D)-(I), representative data were expressed as mean +- SD. One-way ANOVA with Dunnett''s posthoc analysis was used to calculate statistical significance. **** p < 0.0001, *** p < 0.001, ** p < 0.01, and * p < 0.05. NS: no significance.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14871_41541_2019_143_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 3 ZIKV NS4B-C100S induces potent antiviral adaptive immune responses. a - c Six-week-old AB6 ( a ) or WT B6 ( b ) were infected with 2 x 10 4 FFU WT FSS13025ic (WT) and ZIKV NS4B-C100S (C100S). a On day 28, splenocytes of AB6 mice were cultured ex vivo with WT ZIKV for 24 h and were stained for IFN-gamma, CD3, and CD4 or CD8. Total number of T-cell subsets per spleen. b Supernatants from the ex vivo culture were collected on day 2 after WT ZIKV re-stimulation and measured for Th1-cytokine production. c On day 28 after immunization, sera collected from AB6 or B6 mice were measured for NAb titers. Data are presented as means +- SEM, n = 3-7 and are representative of two to three similar experiments. ** P < 0.01 or * P < 0.05 compared with WT group (unpaired t -test).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_7553_JCMM-24-1684-g007.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 7 MSC-TGF-beta1 increased the proportion of Foxp3 + Treg cells. Mononuclear cells were extracted from mice blood and analysed on day 21 post-transplant by flow cytometry on the proportion of Foxp3 + Treg cells. A, Proportion of Foxp3 + Treg cells in CD4 + T cells. B, Quantitative analysis of the proportion of Foxp3 + Treg cells. Data are representative of three independent experiments with 5-7 mice per group. Data are presented as the mean +- SD. * P < .05, ** P < .01, *** P < .001</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8134_10.1177_2040622319860653-fig4.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 4. LGG administration protected against osteoclastogenesis and modulated theimmune response in the BM. (a) Representative images of bone marrow stained by TRAP in the femur(yellow arrows indicate claret-red osteoclast stained by TRAP). Scalebar = 100 mum. ELISA analysis of cell supernatant levels of RANKL (b),TNF-alpha (c), and IL-17 (d) ( n = 10 mice per group). (e)FACS analysis on the ratios of Treg and Th17 cells in CD4 + Tcell subset and the Treg:Th17 cell ratio from the BM( n = 6 mice per group). (f) Representative FACS plotsof the ratio of Treg cells in CD4 + T cell subset of the BM.(g) Representative FACS plots of the ratio of Th17 cells in theCD4 + T cell subset of the BM. Data are expressed as mean+- SD. All data were normally distributed according to the Shapiro-Wilknormality test and analyzed using two-way ANOVA and posthoc tests applying the LSD correction for multiplecomparisons. * p < 0.05 compared with the Shamgroup. # p < 0.05 compared with the LGG+TDFgroup. % p < 0.05 compared with the E.coli +TDF group. $ p < 0.05 compared with the TDF group. ANOVA, analysis of variance; BM, bone marrow; ELISA, enzyme-linkedimmunosorbent assay; FACS, fluorescence-activated cell sorting; IL-17,interleukin-17; LGG, Lactobacillus rhamnosus GG; LSD,least significant difference; RANKL, receptor activator of nuclearfactor kappa-B ligand; SD, standard deviation; TDF, tenofovir disoproxilfumarate; Th17, T-helper 17 cell; TNF-alpha, tumor necrosis factor alpha;TR</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8134_10.1177_2040622319860653-fig6.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 6. LGG regulated the intestinal inflammatory response and permeability. (a) FACS analysis of Treg and Th17 cells in MLNs ( n = 6mice per group). (b) Representative FACS plots of ratio of Treg cells inthe CD4 + T cell subset of MLNs. (c) Representative FACS plotsof the ratio of Th17 cells in the CD4 + T cell subset of MLNs.(d) qPCR analysis measuring the transcript levels of the claudin family( n = 6 mice per group). (e) ELISA analysis of serumlevels of ET ( n = 8-10 mice per group). (f) Serum FD4levels were measured in serum ( n = 9-10 mice pergroup). Data are expressed as mean +- SD. All data were normallydistributed according to the Shapiro-Wilk normality test and analyzedusing two-way ANOVA and post hoc tests applying the LSDcorrection for multiple comparisons. * p < 0.05 compared with the Shamgroup. # p < 0.05 compared with the LGG+TDFgroup. % p < 0.05 compared with the E.coli +TDF group. $ p < 0.05 compared with the TDF group. ANOVA, analysis of variance; ELISA, enzyme-linked immunosorbent assay;ET, endotoxin; FD4, fluorescently labeled dextran; LGG, Lactobacillus rhamnosus GG; LSD, least significantdifference; MLNs, mesenteric lymph nodes; qPCR, quantitative real-timepolymerase chain reaction; TDF, tenofovir disoproxil fumarate; Th17,T-helper 17 cell; Treg, regulatory T cell; ZOL, zoledronic acid.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14869_JCMM-23-5588-g006.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 6 Bryostatin-1 treated Il-10 -/- mice show lower Th1 and Th17 responses than the untreated Il-10 -/- mice. Intracellular cytokine staining and flow cytometric analysis demonstrated a significant decrease in the proportion of IFN-gamma + CD4 + T cells in Bry-1-treated mice compared with untreated Il-10 -/- mice in the spleen (A and B) and MLN (C and D); however, these proportions were still higher than those in WT mice. (E and F) A significant decrease in the proportion of IL-17A + CD4 + T cells was observed in Bry-1-treated mice compared with untreated Il-10 -/- mice in both the spleen (E and F) and MLN (G and H), but these T lymphocyte proportions were still higher than those in WT mice. Bry-1, Bryostatin-1; WT, wild-type; MLN, mesenteric lymph nodes; and NS, no significance. At least three independent experiments with six to eight mice in each group were performed, with one representative experiment is shown. The data are expressed as the mean +- SD. V P < 0.05</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_7860_fgene-10-00545-g001.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">FIGURE 1 Ovalbumin (OVA)-induced acute model of asthma. (A) Pulmonary inflammatory response was increased in the mice challenged with OVA, bar = 20 mum. (B) The airway hyperresponse was elevated in the mice from the asthma group, * p < 0.05 (C) . Sera IgE was significantly increased in the mice from the asthma group, * p < 0.05. (D) CD4 + T cells magnificently sorted from the spleen were validated by flow cytometry. Representative results of two independent experiments with five mice in each group, ** p < 0.01, *** p < 0.01, **** p < 0.0001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5889_gr5.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 5 Immunomodulatory Profile and Functions of TAM-EVs (A and B) Gene set enrichment analysis (GSEA) plots showing the correlation of TAM (TAM-Cell) and TAM-EV protein signatures with genes expressed in FACS-sorted M1-like or M2-like TAMs (A) or prognostic genes across human cancers recorded in the PRECOG database (B). (C) Flow cytometry analysis of CD8 + T cells obtained after priming OT-I splenocytes. (D) Schematic of the experiment shown in (E-G). (E and F) Flow cytometry analysis of CD8 + OT-I proliferation assessed by CellTrace dilution. (E) Representative flow profiles. (F) Quantification of the data (mean +- SEM; n = 4 cell cultures/condition). Statistics by two-way ANOVA, using Sidak's multiple comparison test. (G) ELISA-based quantification of IFNgamma in medium conditioned by OT-I CD8 + T cells. Data are shown as mean +- SEM (n = 4 cell cultures/condition). Statistics as in (F). (H) Flow cytometry analysis of CD8 + T cells purified from the spleen of C57BL/6 mice. (I) Schematic of the experiment shown in (J and K). (J) Flow cytometry analysis of CD8 + T cell proliferation assessed by CellTrace dilution (mean +- SEM; n = 4 cell cultures/condition). Statistics by one-way ANOVA, using Tukey's multiple comparison test. (K) ELISA-based quantification of IFNgamma in medium conditioned by CD8 + T cells (mean +- SEM; n = 4 cell cultures/condition). Statistics as in (J). (L) Flow cytometry analysis of CD4 + T cells purified from the spleen of BALB/c mice. (M) Schematic o</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8325_nihms-1528318-f0009.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Extended Data Figure 5: Nonconditioned transplantation into immunodeficient recipients (a) Schematic of nonconditioned allogeneic transplantation: 100 CD150 + CD34 - KSL cells from C57BL/6-CD45.2 mice were expanded for 28-days before being transplanted into non-conditioned immunodeficient NOD/SCID recipients. (b) 4-week donor PB chimerism of 100 fresh HSCs (n=5) or a 28-day HSC culture derived from 100 HSCs (n=5), transplanted as described in ( a ). Each column represents an individual mouse. N.D. denotes not detected. (c) Example flow cytometric plots displaying T cell (CD4/CD8) and B cell (CD45RA, also known as B220) PB lineages within non-conditioned NOD/SCID mice at 16-weeks post-transplantation (representative of 5 mice), as described in ( a ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14867_ADVS-6-1802042-g004.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 4 SMU-Z1 increases splenocyte proliferation, CD8 + /CD4 + ratio, and TLR2 expression. A) SMU-Z1 treatment accelerated splenocyte proliferation at different concentrations. B) Time kinetics of SMU-Z1 stimulated primary splenocyte proliferation at 5 x 10 -6 m . Cell proliferation was tested by measuring CCK8 absorbance at 450 nm at different time intervals. C) Percentages of CD19 + B cells present within splenocytes were determined by flow cytometry at various time points after treatment with PBS, 5 ug Pam 3 CSK 4 (Pam3), or 0.1 mg of SMU-Z1 in C57BL/6 mice. D) Representative graphs of CD4 + and CD8 + T cells from PBS, Pam 3 CSK 4 (Pam3), or SMU-Z1-treated mice. The percentage of CD8 + and ratio of CD8 + /CD4 + T cells increased after treatment with SMU-Z1. E) Percentage of TLR2 positive cells (CD3 + CD8 + TLR2 + ) in the spleen. Results shown are average values from three independent experiments, and the data are presented as mean +- SD. *, p < 0.01; **, p < 0.001 compared to the control group.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14870_acd-30-909-g002.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 2 CS2164 affects the frequencies of T-cell subpopulations in the spleen. The frequencies of CD4 + and CD8 + T cells (a) and CD25 + Foxp3 + Tregs (b) in the spleen from vehicle-treated or CS2164-treated mice described in Fig. 1 were analyzed by flow cytometry. The representative plots are shown and the accumulative data are expressed as mean +- SD from one of two independent experiments. ** P < 0.01 compared with the vehicle control group.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8142_MI2019-4652596.005.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 5 (a) BMDCs were transfected with LV-IL10-GFP or LV-mock-GFP to acquire DC-IL10 and DC-mock cells, respectively. Mice were randomly divided into G1 (control group), G2 (model group), G3 (DC-mock-treated group), and G4 (DC-IL10-treated group). Liver fibrosis (G2, G3, and G4) was induced by twice a week intraperitoneal injection of 40% CCl4 as a 2 : 3 mixture with olive oil for 8 weeks. The control group was administered with the same volume of olive oil only, twice a week for 8 weeks. In the 6th week of CCl4 injection, the mice in the G3 and G4 groups were treated with DC-mock or DC-IL10 (1 x 10 6 /0.2 ml) suspended in RPMI 1640 into the tail vein (twice a week for 2 weeks) till the 8th week, while the control group and model group received equivalent volumes of RPMI 1640 tail vein injection instead of DC treatment. All mice were sacrificed 72 h following the final CCl4 or olive oil injection at the 8th week. Splenocytes were isolated from the spleen in each group of mice to analyze the immune-regulatory effect of DC-IL10 on Th17 cells. The lymphocytes were stimulated for 5 h with PMA and BFA in RPMI 1640 containing 10% FBS and then stained with anti-CD4-FITC. They were fixed and permeabilized with Fix/PERM kit and stained intracellularly with anti-IL-17-PE. The percentages of Th17 cells were determined by flow cytometry. Cells stained with IgG isotype control were used as controls. (b) DC-IL10 suppresses the generation of Th17 cells. The percentages of Th17 cells in</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14826_41598_2018_37175_Fig9_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 9 Representative gating strategies used to analyze cell types by flow cytometry. Shown are representative dot plots with gating for CD4+/CD62L+ and CD8+/CD62L+ T-cells ( a ), T-regulatory Cells (CD4+/CD25+/FOXP3+) ( b ), CD4+ Memory T-cells (CD4+/CD44+/CD62L+) and CD8+ Memory T-cells (CD8+/CD44+/CD62L+) ( c ), and CCR7+/CD4+ Memory T-cells and CCR7+/CD8+ Memory T-cells ( d ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14866_biolopen-8-036244-g5.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 5. Enhanced Th2 cytokine responses in the draining lymph nodes following challenge with OVA. Ten IL-31RA KO mice were sensitized intraperitoneally with 100 ug OVA in the presence of aluminum hydroxide at days 0, 7 and 14, and an intranasal challenge with 5% OVA started on day 21 for 7 consecutive days. (A) Lungs were collected for detection of Th2 and Th17 infiltrates by immunohistochemistry ( n =6). (B) CD4 + T cells and (C) Th1, Th2, Th9 and Th17 populations in peripheral blood were analyzed by flow cytometry ( n =5-10). (D) Draining lymph node cells from OVA-challenged mice were stimulated with 20 mug/ml of OVA for 48 h. Levels of IFN-gamma, IL-4, IL-13 and IL-17 in supernatants detected by ELISA ( n =5-6). Data expressed as the mean+-s.e.m. Significance was determined by two-tailed Student's t -test. The experiment was repeated twice.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14866_biolopen-8-036244-g6.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 6. IL-31R signaling suppressed the proliferation of CD4 + T cells. Purified CD4 + T cells from WT and IL-31RA KO mice were stimulated with anti-CD3/anti-CD28. The activation ( n =4) (A) and proliferation ( n =4) (B) of CD4 + T cells were assayed by flow cytometry. All values are plotted and lines indicate means. Statistical significance was determined by two-tailed Student's t - tests. The experiment was repeated twice. Ctrl, control; Act, activation.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5004_elife-37851-fig1.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 1. Dual-color Bcl11b reporter strategy can reveal epigenetic mechanisms controlling T-cell lineage commitment. ( A ) Overview of early T-cell development. Bcl11b turns on to silence alternate fate potentials and drive T-cell fate commitment. ETP - early thymic progenitor; DN2 - CD4 - CD8 - double negative-2A progenitor; DP - CD4 + CD8 + ; NK - natural killer; DC - dendritic cell. ( B ) Dual-allelic Bcl11b reporter cells, where two distinguishable fluorescent proteins (YFP and mCherry) are inserted non-disruptively into the same sites on the two endogenous Bcl11b loci. ( C ) Flow cytometry plots show cKit versus CD25 levels in CD4 - CD8 - double negative (DN) thymic progenitors (left), along with Bcl11b-YFP versus Bcl11b-mCh expression levels in the indicated DN progenitor subsets from dual Bcl11b reporter mice. Arrowheads indicate cells expressing one copy of Bcl11b . ( D ) Flow plots show Bcl11b-YFP versus Bcl11b-mCh levels in CD4 + CD8 + double positive (DP) T-cell precursors from the thymus (left), or CD4 (center) or CD8 (right) T-cells from the spleen. Results are representative of analysis of 6-8 mice from two independent experiments. See also Figure 1--figure supplement 1 . Figure 1--figure supplement 1. Experimental strategy for generating different Bcl11b reporter mouse strains. The two Bcl11b loci were targeted in embryonic stem (ES) cells using homologous recombination, followed by drug selection using the indicated drug-res</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5004_elife-37851-fig3.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 3. A distal enhancer region controls Bcl11b activation probability. ( A ) Schematic of normal and enhancer-deleted two-color Bcl11b reporter strains (left). Genome browser plots (right), showing +850 kb enhancer of Bcl11b, showing distributions of histone marks (H3K4me2, H3K27me3, and H3K27Ac) and an associated LncRNA ( Isoda et al., 2017 ). Orientation is with transcription from left to right (reversed relative to genome numbering). Gray shaded area indicates the enhancer region deleted using gene targeting (removed region: chr12:108,396,825-108,398,672, mm9). ( B ) Flow cytometry plots show Bcl11b-mCh versus Bcl11b-YFP levels in developing T-cell populations from dual Bcl11b reporter mice, either with an intact YFP enhancer (top), or a disrupted YFP enhancer (bottom). Results are representative of two independent experiments. ( C ) Bar graphs showing the percentages of cells in early thymic populations with mono- and bi-allelic expression of wildtype mCherry and wildtype YFP versus mutant YFP alleles in wildtype Bcl11b YFP/mCh and Bcl11b YFPDeltaEnh/mCh dual reporter mice, demonstrating the reduced frequency of mutant YFP allele expression relative to the wildtype mCherry allele in the same cells. Each bar shows results from one mouse; n = 4 mice of each strain are shown. ( D ) DN2 progenitors were sorted for different Bcl11b allelic activation states as indicated, cultured on OP9-DL1 monolayers for 4 days, and analyzed using flow cytometry. Flow</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5004_elife-37851-fig3-figsupp4.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Figure 3--figure supplement 4. Thymocytes from homozygous mutant enhancer Bcl11b YFPDeltaEnh/YFPDeltaEnh mice are able to generate T-cell subsets expressing Bcl11b at normal levels relative to wild-type enhancer Bcl11b YFP/YFP mice. Representative FACS plots showing gates used for CD4 and CD8 double negative (DN), double positive (DP) and single positive (CD4 and CD8) populations (left plots) and the relative levels of Bcl11b-YFP in each subset generated from enhancer mutant and wild-type mice (right histograms, n = 2 for each genotype).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14865_13046_2018_929_Fig6_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 6 The influence of apigenin on B16-F10 melanoma xenograft tumor growth and host T cell immunity. a B16-F10 melanoma cells were subcutaneously inoculated into female C57BL/6 wild-type mice. After 4 days, xenograft-bearing mice were randomly divided into 3 groups to receive saline (control), curcumin, or apigenin by daily oral gavage for 12 consecutive days, before sacrifice and tumor resection. b B16-F10 xenograft tumor volume was measured every other day during the treatment and plotted. c the weight of resected B16-F10 xenograft tumor was measured and plotted. d tumor tissue sections were analyzed by immunohistochemistry using anti-Ki-67, anti-CD4, and anti-CD8 antibodies. Scale bar = 50 mum. Magnified insets show CD4 or CD8 positive stained cells. e tumor tissues were lysed to detect PD-L1 expression by immunoblotting. GAPDH was used as a loading control. f splenocyte preparations from different groups were analyzed by flow cytometry with CD4 and CD8 antibodies. g the quantitation of CD4 and CD8 positive cells from different treatment groups in F (total population as 100%). h spleen/body weight ratios of mice with different treatments. i C57BL/6 mice with 3 groups were treated by oral gavage with saline, curcumin (50 mg/kg), or apigenin (150 mg/kg) once a day for 2 weeks. DCs were isolated from mouse spleens and PD-L1 expression in DCs was then detected by immunoblotting. Bar chart shows relative quantification of PD-L1 levels (control as 100%). GAPDH was used as a loa</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14868_nihms-1008414-f0001.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_4799_41467_2018_6227_Fig6_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 6 Co-infection induces early apoptosis of CD4 + T cells in the popliteal lymph node (pLN). Joint inflammation ( a ), viraemia ( b ) and viral load in the whole body ( c ) and footpad ( d ) of WT + CHIKV ( n = 5), WT + CHIKV + PbA ( n = 5), LTa -/- + CHIKV ( n = 4) and LTa -/- + CHIKV + PbA ( n = 4) groups. The orange box denotes suppression of joint inflammation (5-8 dpi) in co-infected WT mice compared to WT + CHIKV, which is lost in the co-infected LTa - / - mice. Data from co-infected mice was compared with their respective CHIKV infected controls on the same genetic background using Mann-Whitney two-tailed analysis. Comparisons between WT + CHIKV and WT + CHIKV + PbA are represented by *P < 0.05 and **P < 0.01; comparisons between LTa -/- + CHIKV and LTa -/- + CHIKV + PbA are represented by + P < 0.05. Quantification of CHIKV-specific CD4 + T cells (ELISPOT) ( e ), total CD4 + T cells (flow cytometry) ( f ) and late apoptotic CD4 + T cells ( g ) in the pLN of mock, CHIKV and CHIKV + PbA ( n >= 5 per group) at 2, 4, 5 and 6 dpi. e Representative ELISPOT images showing spots generated by virus-stimulated CD4 + T cells isolated from 100,000 pLN cells (4 and 5 dpi) and 200,000 pLN cells (6 dpi) in CHIKV-infected and co-infected mice. g Representative dot plots displaying late apoptotic CD4 + T cells gating on 6 dpi. Late apoptotic CD4 + T cells are defined as CD45 + CD3 + CD4 + FVD + AnnexinV + cells. Data shown are pooled from four independent</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_4799_41467_2018_6227_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 5 Co-infection limits pathogenic CD4 + T-cell and pro-inflammatory immune-cell infiltration into the joints. a Representative IHC images of CD3 staining in the joints at 6 dpi. Scale bar: 100 mum. Quantification of CD3 + cells (IHC) ( b ), CD3 + cells (flow cytometry) ( c ), activated (LFA-1 + ) CD4 + T cells (flow cytometry) ( d ) and CHIKV-specific CD4 + T cells (ELISPOT) ( e ) in the joints of CHIKV, CHIKV + PbA and Py17x (-4 dpi) + CHIKV ( n >= 5 per group) at 6 dpi. Flow cytometric quantification of neutrophils ( f ), NK cells ( g ) and CD11b + Ly6C + monocytes ( h ) in the joints of CHIKV, CHIKV + PbA and Py17x (-4 dpi) + CHIKV ( n >= 5 per group) at 6 dpi. Data represent the means +- SD and were analyzed by one-way ANOVA with Tukey post hoc test ( *P < 0.05, **P < 0.01 and * **P < 0.001). Each data point in the dot plot represents one mouse. Data are representative of two independent experiments. Activated CD4 + T cells are defined as CD45 + /CD3 + CD4 + /LFA-1 + cells. Neutrophils and NK cells are defined as CD45 + /CD11b + /Ly6G + and CD45 + /NK1.1 + cells, respectively. CD11b + /Ly6C + monocytes were gated after gating out all T cells, neutrophils, NK cells and B cells. Abbreviations: CHIKV, Chikungunya virus; dpi, days post infection; IHC, immunohistochemistry; NK, natural killer; ns, not significant; PbA, Plasmodium berghei -ANKA</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14844_12974_2018_1304_Fig6_HTML.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Fig. 6 Microglia ablation in APP-PS1 mice resulted in increased CD3 + /CD8 + T-cell numbers in the brain, and CD8 + T-cell numbers were highly increased in cortical brain regions of APP-PS1 mice interacting with Iba1 + /TMEM119 + and Iba1 + /TMEM119 - cells. Detailed immunohistochemical analysis of CD8 + T-cell numbers (green) in brains of APP-PS1 mice revealed similar CD8 + T-cell numbers compared to WT when analyzing total sagittal brain sections; however, CD8 + T-cell numbers were significantly increased in cortical brain regions of APP-PS1 mice compared to WT ( a ). T-cells were mechanically isolated from total brain hemispheres and quantitatively analyzed by flow cytometry after ablation of microglia cells ( b , gated for single-living CD45 + /CD3 + cells; CD4 + red, CD8 + green). The total number of CD45 + /CD3 + T-cells was significantly increased in APP-PS1 mice treated with PLX5622 compared to WT-treated mice ( c ). CD3 + /CD4 + T-cell numbers trend to be increased in APP-PS1 mice treated with PLX5622 ( d ). CD3 + /CD8 + T-cell numbers were significantly increased in APP-PS1 mice treated with PLX5622 compared to APP-PS1 and WT PLX5622-treated mice ( e ). CD8 + T-cells in APP-PS1 mice were located directly in the brain parenchyma and observed in different interaction types with Iba1 + cells (white), showing either no contact, intermediate, or very tight interaction with brains Iba1 + cells ( f ). Performing confocal microscopy, we observed very tight cell to cell inte</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14844_12974_2018_1304_MOESM7_ESM.jpg?time=20240507?time=20240507" alt="CD4 Antibody in Flow Cytometry (Flow)" title="CD4 Antibody (11-0041-82) in Flow"> <figcaption itemprop="caption">Additional file 7: Figure S7. Flow cytometric data of brain isolated T-cells were analyzed for gender-specific differences: (A) Female APP-PS1 mice had significantly increased numbers of CD3 + T-cells when compared specifically to female WT mice, however this was not seen in male mice (B). (C) Female APP-PS1 had increased numbers of CD3 + T-cells compared to male APP-PS1 mice. (D) The number of CD3 + /CD4 + T-cells was significantly increased in female APP-PS1 compared to female WT mice, whereas male mice of both genotypes had the same cell numbers in the brain (E). (F) APP-PS1 female mice had higher numbers of CD3 + /CD4 + T-cells compared to male APP-PS1 mice. (G) There was a trend for higher CD3 + /CD8 + T-cell numbers in the brain of female APP-PS1 mice compared to female WT mice, however this was not seen in male animals (H). (I) Female APP-PS1 mice had higher numbers of CD3 + /CD8 + T-cells compared to male APP-PS1 animals. PLX5622 treatment in APP-PS1 mice of both sexes showed an increase in the number of CD3 + , CD3 + /CD4 + and CD3 + /CD8 + T-cells in the brain. One-way ANOVA with Tukey's Multiple Comparison Test (A, B, D, E, G, H, n = 3-5/group) and Unpaired Student's T-test (A, C, D, F, G, I) for comparison of only two groups were performed (n = 3-5/group). (TIF 743 kb)</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/11004182-CD4-GK1-5-RE-AV-20170920122035.jpg?time=20240507?time=20240507" alt="CD4 Antibody" title="CD4 Antibody (11-0041-82)"> <figcaption itemprop="caption">Staining of mouse splenocytes. As expected based on known relative expression patterns, CD4 clone GK1.5 stains about 25% of total lymphocytes and does not stain CD45R (B220)+ B cells. Details: Balb/c splenocytes were surface stained with CD45R (B220, clone RA3-6B2) and Rat IgG2b Isotype Control or CD4 (clone GK1.5). Cells in the lymphocyte gate were used for analysis. {RE}</figcaption> </figure> </div> </div> </noscript> <div id="tf-related-products-container-new"></div> <div class="product-details"> <div class="container"> <div class="row"> <div class="large-span-12 medium-span-12 small-span-12"> <h2 class="pdp-sub-heading product_details_heading">Product Details</h2></div> <div class="hidden-sku"> <h2>11-0041-82</h2> </div> <div class="product-detail-section tested-app-section new-tbl-design product-detail-section table-spec"> <div class="product-container-head"> <div class="product-item"> Applications </div> <div class="product-item dilution-lbl-head "> Tested Dilution </div> <div class="product-item published-applications"> Publications </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (IHC)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHC-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 20 publications</span> <span class="mobile-view">20 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (Paraffin) (IHC (P))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCP-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (Frozen) (IHC (F))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 2 publications</span> <span class="mobile-view">2 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunocytochemistry (ICC/IF)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#ICCIF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 7 publications</span> <span class="mobile-view">7 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Flow Cytometry (Flow)</h2></div> <div class="product-item "> <span class="dilution-lbl">0.25 µg/test</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Flow-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 380 publications</span> <span class="mobile-view">380 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Functional Assay (Functional)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Functional-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 2 publications</span> <span class="mobile-view">2 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Miscellaneous PubMed (Misc)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Misc-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 3 publications</span> <span class="mobile-view">3 publications</span></a> </div> </div> </div> <div class="product-detail-section tested-app-section new-tbl-design product-specific-section table-spec"> <div class="product-container-head"> <div class="product-item">Product Specifications</div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Species Reactivity</h2> </div> <div class="product-item left-flex-cls"> <span title="Mus musculus">Mouse</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Published species</h2> </div> <div class="product-item left-flex-cls"> <span>Fish,</span> <span>Human,</span> <span>Mouse,</span> <span>Rat</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2> Host/Isotype</h2> </div> <div class="product-item left-flex-cls"> <span title="Rattus">Rat / IgG2b, kappa</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Recommended Isotype Control</h2> </div> <div class="product-item left-flex-cls"> <a href="//www.thermofisher.com/antibody/product/11-4031-82"> Rat IgG2b kappa Isotype Control (eB149/10H5), FITC, eBioscience™</a> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Class</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Monoclonal </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Type</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Antibody </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Clone</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> GK1.5 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Conjugate</h2> </div> <div class="product-item left-flex-cls"> <a ng-if="$ctrl.checkConjugate('FITC ') && '/us/en/home/life-science/cell-analysis/fluorophores/fluorescein.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye'.trim() != ''" href="/us/en/home/life-science/cell-analysis/fluorophores/fluorescein.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye" ng-attr-target="{{$ctrl.getRequestCustomLinkTarget()}}" class="conjugate-value">FITC </a> <span ng-if="($ctrl.checkConjugate('FITC ') && '/us/en/home/life-science/cell-analysis/fluorophores/fluorescein.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye'.trim() == '')" class="conjugate-value">FITC </span> <span ng-if="!$ctrl.checkConjugate('FITC ')" class="conjugate-value">FITC </span> <div class="dropdown conjugate-dropdown"> <button class="btn-link conjugate-btn" type="button" data-toggle="dropdown"> View additional formats <span class="caret"></span> </button> <ul class="dropdown-menu dropdown-menu-fixed"> <li><a class="conjugate-color-padding" href="/antibody/product/14-0041-82"> Unconjugated <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/53-0041-82"> Alexa Fluor 488 <span class="conjugate-indicator" style="background-color:#36FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/58-0041-82"> Alexa Fluor 532 <span class="conjugate-indicator" style="background-color:#B3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/56-0041-82"> Alexa Fluor 700 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/17-0041-82"> APC <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/47-0041-82"> APC-eFluor 780 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/13-0041-82"> Biotin <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/363-0041-82"> Brilliant UV 395 <span class="conjugate-indicator" style="background-color:#8000A1"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/365-0041-82"> Brilliant UV 563 <span class="conjugate-indicator" style="background-color:#C3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/376-0041-82"> Brilliant UV 661 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/367-0041-82"> Brilliant UV 737 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/414-0041-82"> Brilliant Violet 480 <span class="conjugate-indicator" style="background-color:#00C0FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/406-0041-82"> Brilliant Violet 605 <span class="conjugate-indicator" style="background-color:#FFAD00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/48-0041-82"> eFluor 450 <span class="conjugate-indicator" style="background-color:#0028FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/69-0041-82"> eFluor 506 <span class="conjugate-indicator" style="background-color:#00FF54"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/50-0041-82"> eFluor 660 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/16-0041-82"> Functional Grade <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02B01-A"> NovaFluor Blue 510 <span class="conjugate-indicator" style="background-color:#00FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02B02-A"> NovaFluor Blue 530 <span class="conjugate-indicator" style="background-color:#5EFF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02B03-A"> NovaFluor Blue 555 <span class="conjugate-indicator" style="background-color:#B3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02B04-A"> NovaFluor Blue 585 <span class="conjugate-indicator" style="background-color:#FFEF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02B05-A"> NovaFluor Blue 610-30S <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02B06-A"> NovaFluor Blue 610-70S <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02B08-A"> NovaFluor Blue 660-120S <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02B07-A"> NovaFluor Blue 660-40S <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T03B09-A"> NovaFluor Blue 690 <span class="conjugate-indicator" style="background-color:#970000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T03B10-A"> NovaFluor Blue 725 <span class="conjugate-indicator" style="background-color:#610000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T03B11-A"> NovaFluor Blue 760 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T03B12-A"> NovaFluor Blue 800 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02R01-A"> NovaFluor Red 660 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02R02-A"> NovaFluor Red 685 <span class="conjugate-indicator" style="background-color:#970000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02R03-A"> NovaFluor Red 700 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02R04-A"> NovaFluor Red 710 <span class="conjugate-indicator" style="background-color:#820000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T03U01-A"> NovaFluor UV 765 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T03V01-A"> NovaFluor Violet 690 <span class="conjugate-indicator" style="background-color:#AB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T03V02-A"> NovaFluor Violet 745 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T03V03-A"> NovaFluor Violet 800 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02Y01-A"> NovaFluor Yellow 570 <span class="conjugate-indicator" style="background-color:#E1FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02Y02-A"> NovaFluor Yellow 590 <span class="conjugate-indicator" style="background-color:#FFDF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02Y03-A"> NovaFluor Yellow 610 <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02Y04-A"> NovaFluor Yellow 660 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02Y05-A"> NovaFluor Yellow 690 <span class="conjugate-indicator" style="background-color:#970000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02Y06-A"> NovaFluor Yellow 700 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T02Y07-A"> NovaFluor Yellow 730 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M001T03Y09-A"> NovaFluor Yellow 810 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/12-0041-82"> PE <span class="conjugate-indicator" style="background-color:#F0FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/15-0041-82"> PE-Cyanine5 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/25-0041-82"> PE-Cyanine7 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/61-0041-82"> PE-eFluor 610 <span class="conjugate-indicator" style="background-color:#FF9B00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/46-0041-82"> PerCP-eFluor 710 <span class="conjugate-indicator" style="background-color:#820000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/62-0041-82"> Super Bright 436 <span class="conjugate-indicator" style="background-color:#3D00FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/63-0041-82"> Super Bright 600 <span class="conjugate-indicator" style="background-color:#FFBE00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/64-0041-82"> Super Bright 645 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/67-0041-82"> Super Bright 702 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/78-0041-82"> Super Bright 780 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li class="drop-down-link-ctnr"> <a class="conjugate-dropdown-link" href="/us/en/home/global/forms/antibody-conjugates-custom-form.html" ng-attr-target="$ctrl.getRequestCustomLinkTarget()">Request custom conjugation <svg class="svg-icon external-link-icon" ng-if="$ctrl.showExternalLinkIcon()"> <use href="#external-link"></use> </svg> </a> </li> </ul> </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Excitation/Emission Max</h2> </div> <div class="product-item left-flex-cls"> <span>498/517 nm</span> <a target="_blank" class="spectra-view" href="/order/fluorescence-spectraviewer?SID=srch-svtool&UID=2761old_2"> <span class="view-spectra"> View spectra</span> <span class="spectra-view-icon "><img src="/order/genome-database/assets/img/spectra.png" alt="spectra"/></span> </a> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Form</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Liquid </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Concentration</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.5 mg/mL </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Purification</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Affinity chromatography </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage buffer</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> PBS, pH 7.2 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Contains</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.09% sodium azide </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 4° C, store in dark, DO NOT FREEZE! </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Shipping conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Ambient (domestic); Wet ice (international) </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"><h2>RRID <span id="rrid-tooltip" class="rrid-tooltip-icon" ng-include="'/order/genome-database/webapp/assets/core/img/svg/mono_tooltip.svg'" data-toggle="tooltip" ng-click="$ctrl.showRridTooltip()" close-tooltip="$ctrl.closeRridTooltip()" title="Research Resource Identifiers (#RRID) are ID numbers assigned to help researchers cite key resources in the biomedical literature to improve transparency of research methods."> </span></h2> </div> <div class="product-item left-flex-cls">AB_464892</div> </div> </div> <div class="product-specific-details"> <div class="product-specific-details-tbl product-specific-add-border" > <div class="product-info-para"> <h4 class="product-info-para-heading"> Product Specific Information </h4> <p>Description: The GK1.5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of GK1.5 is blocked by RM4-5.<br /><br />Applications Reported: The GK1.5 antibody has been reported for use in flow cytometric analysis.<br /><br />Applications Tested: This GK1.5 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.25 µg per test A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.<br /><br />Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.<br /><br />Filtration: 0.2 µm post-manufacturing filtered.</p> </div> <div class="product-info-para"> <h4 class="product-info-para-heading"> Target Information </h4> <p class="product-specific-target-info">The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].</p> </div> <p class="product-details-regulatoryStmt">For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.</p> </div> <div class="product-detail-panel-builder"> <tf-promo-ad ng-if="$ctrl.showPromoAd" show-promo-ad="$ctrl.showPromoAd"></tf-promo-ad> <div class="product-detail-video"> <div tf-video-player-new video-id="6206990159001" player-width="368" player-height="210"></div> <div class="panel-builder"> <h4 class="product-info-para-heading"> How to use the Panel Builder </h4> <p>Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.</p> </div> </div> </div> </div> </div> </div> </div> <div id="rootPdpDocLoader"></div> <div id="tf-related-products-container" ng-show="emptyRelatedProductsWidget === false" > <related-products-container ng-if="showRelatedProductsWidget === true" base-url="'/api/magellan/related-products-ui/widget/v2/'" product-type="'antibody'" product-sub-type="'primary'" product-id="'11-0041-82'" country-code="'sg'" iso-language="'en'" > </related-products-container> </div> <div class="tf-pdp-divider" ng-if="emptyRelatedProductsWidget === false" ></div> <div class="references reference-section-3" id="references-component-id"> <div id="references-section-id"> <reference-section ng-if="loadReferences" default-display-card-limit="3" reference-count="415" sub-type="'Antibody'" application-data='{"citationApplications":[{"applicationAbbreviation":"IHC","citations":[{"title":"Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.","summary":"Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunocytochemistry","authors":"Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y","literatureId":"33916809","journal":"International journal of molecular sciences","volume":"22","publishedDate":"Apr 3, 2021, 4:00:00 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PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Chen AD,Cao JX,Chen HC,Du HL,Xi XX,Sun J,Yin J,Jing YH,Gao LP</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Aug 26 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36570798"> <div itemprop="name">IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells.</div> </a> <div itemprop="about">Journal of immunology research</div> <div itemprop="author">Cheng L,Jiao Y,Jiang W,Zhang X,Zhang L,Jia G</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 27 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36304255"> <div itemprop="name">Interferon-<i>γ</i> Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway.</div> </a> <div itemprop="about">Disease markers</div> <div itemprop="author">Xiong P,Liu T,Chen Y,Xu Q,Hu X,Han F,Shi L</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 31 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36465184"> <div itemprop="name">CD4<sup>+</sup> CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.</div> </a> <div itemprop="about">Aging and disease</div> <div itemprop="author">Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35562873"> <div itemprop="name">Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Son SE,Koh JM,Im DS</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Apr 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35562873"> <div itemprop="name">Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Son SE,Koh JM,Im DS</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Apr 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36456548"> <div itemprop="name">Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Del Rio Oliva M,Basler M</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32243083"> <div itemprop="name">Withdrawn: Parecoxib inhibits inflammatory responses in a mouse model of sepsis.</div> </a> <div itemprop="about">FEBS open bio</div> <div itemprop="author">No authors listed</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to suggest that Parecoxib inhibits the inflammatory response and has protective effects against sepsis in mice, and may have potential as a novel therapeutic method for treating sepsis.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35637736"> <div itemprop="name">Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Severance AL,Kinder JM,Xin L,Burg AR,Shao TY,Pham G,Tilburgs T,Goodman WA,Mesiano S,Way SS</div> <div itemprop="description">11-0041-82 was used in Flow cytometry/Cell sorting to show that the female reproductive hormone, progesterone, coordinates immune tolerance by stimulating expansion of FOXP3+ regulatory T cells.</div> <div itemprodp="datePublished">Fri Jun 17 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35173168"> <div itemprop="name">Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to demonstrate that Lin28B promotes lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.</div> <div itemprodp="datePublished">Wed Feb 16 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35313999"> <div itemprop="name">Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling.</div> </a> <div itemprop="about">BMC pharmacology & toxicology</div> <div itemprop="author">Yang Y,Song S,Nie Y,Chen R,Chen P</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to demonstrate that lentinan antagonizes SA-induced hepatotoxicity in mice, may be involved in the downregulations of pro-inflammatory OX40 or IL-17A and the activation of anti-oxidative Nrf2, NQO1 signals.</div> <div itemprodp="datePublished">Tue Mar 22 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36054080"> <div itemprop="name">Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC.</div> </a> <div itemprop="about">Molecular oncology</div> <div itemprop="author">Ma W,Wan Y,Zhang J,Yao J,Wang Y,Lu J,Liu H,Huang X,Zhang X,Zhou H,He Y,Wu D,Wang J,Zhao Y</div> <div itemprop="description">11-0041-82 was used in Flow cytometry/Cell sorting to suggest that targeting the GAS2/CXCR4 axis is a potential therapeutic strategy for T-ALL.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35731867"> <div itemprop="name">Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Poh AR,Love CG,Chisanga D,Steer JH,Baloyan D,Chopin M,Nutt S,Rautela J,Huntington ND,Etemadi N,O'Brien M,O'Keefe R,Ellies LG,Macri C,Mintern JD,Whitehead L,Gangadhara G,Boon L,Chand AL,Lowell CA,Shi W,Pixley FJ,Ernst M</div> <div itemprop="description">11-0041-82 was used in Flow cytometry/Cell sorting to suggest that therapeutic targeting of HCK activity enhances response to immunotherapy by simultaneously stimulating immune cell activation and inhibiting the immunosuppressive tumor microenvironment.</div> <div itemprodp="datePublished">Fri Jun 24 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35821848"> <div itemprop="name">Structural and Functional Changes in Aged Skin Lymphatic Vessels.</div> </a> <div itemprop="about">Frontiers in aging</div> <div itemprop="author">Kataru RP,Park HJ,Shin J,Baik JE,Sarker A,Brown S,Mehrara BJ</div> <div itemprop="description">11-0041-82 was used in Flow cytometry/Cell sorting to quantitatively analyze the effects of aging on skin initial and collecting lymphatic vessels, dendritic cell migration, cutaneous lymphatic pumping, and VEGFR-3 signaling in lymphatic endothelial cells (LECs).</div> <div itemprodp="datePublished">Fri Aug 25 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35320716"> <div itemprop="name">Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Stienne C,Virgen-Slane R,Elmén L,Veny M,Huang S,Nguyen J,Chappell E,Balmert MO,Shui JW,Hurchla MA,Kronenberg M,Peterson SN,Murphy KM,Ware CF,Šedý JR</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Tue Mar 22 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35694296"> <div itemprop="name">Protective Effect of Poria Cocos Polysaccharides on Fecal Peritonitis-Induced Sepsis in Mice Through Inhibition of Oxidative Stress, Inflammation, Apoptosis, and Reduction of Treg Cells.</div> </a> <div itemprop="about">Frontiers in microbiology</div> <div itemprop="author">Wu Y,Li D,Wang H,Wan X</div> <div itemprop="description">11-0041-82 was used in Flow cytometry/Cell sorting to show that PCPs have pharmacological and biological effects on FP-induced septic mice, and its molecular mechanism is related to antioxidative, anti-inflammation, anti-apoptosis, and the reduction of Treg activity in splenic cells.</div> <div itemprodp="datePublished">Sat Jul 16 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35839070"> <div itemprop="name">MIF confers survival advantage to pancreatic CAFs by suppressing interferon pathway-induced p53-dependent apoptosis.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Suresh V,Dash P,Suklabaidya S,Murmu KC,Sasmal PK,Jogdand GM,Parida D,Sethi M,Das B,Mohapatra D,Saha S,Prasad P,Satoskar A,Senapati S</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to report that the PSCs of mouse or cancer-associated fibroblast cells (CAFs) of human expresses MIF and its receptors, whose expression gets upregulated upon LPS or TNF-α stimulation.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33238133"> <div itemprop="name">Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34140674"> <div itemprop="name">Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19.</div> </a> <div itemprop="about">Nature nanotechnology</div> <div itemprop="author">Li Z,Wang Z,Dinh PC,Zhu D,Popowski KD,Lutz H,Hu S,Lewis MG,Cook A,Andersen H,Greenhouse J,Pessaint L,Lobo LJ,Cheng K</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33398181"> <div itemprop="name">NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34593756"> <div itemprop="name">Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.</div> </a> <div itemprop="about">International journal of oral science</div> <div itemprop="author">Zhao X,Liu J,Zhang C,Yu N,Lu Z,Zhang S,Li Y,Li Q,Liu J,Liu D,Pan Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 30 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33970189"> <div itemprop="name">Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33842459"> <div itemprop="name">High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Apr 13 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33842459"> <div itemprop="name">High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Apr 13 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32859802"> <div itemprop="name">Dynamic changes in the systemic immune responses of spinal cord injury model mice.</div> </a> <div itemprop="about">Neural regeneration research</div> <div itemprop="author">Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32859802"> <div itemprop="name">Dynamic changes in the systemic immune responses of spinal cord injury model mice.</div> </a> <div itemprop="about">Neural regeneration research</div> <div itemprop="author">Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33510091"> <div itemprop="name">VX-765 reduces neuroinflammation after spinal cord injury in mice.</div> </a> <div itemprop="about">Neural regeneration research</div> <div itemprop="author">Chen J,Chen YQ,Shi YJ,Ding SQ,Shen L,Wang R,Wang QY,Zha C,Ding H,Hu JG,Lü HZ</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18.</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32854548"> <div itemprop="name">Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.</div> </a> <div itemprop="about">Human gene therapy</div> <div itemprop="author">Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34080653"> <div itemprop="name">CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Xian W,Wu J,Li Q,Du X,Wang N,Chen D,Gao W,Cao J</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34080653"> <div itemprop="name">CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Xian W,Wu J,Li Q,Du X,Wang N,Chen D,Gao W,Cao J</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33841570"> <div itemprop="name">Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.</div> </a> <div itemprop="about">Oncology letters</div> <div itemprop="author">Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33790992"> <div itemprop="name">Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.</div> </a> <div itemprop="about">Experimental and therapeutic medicine</div> <div itemprop="author">Zhang Y,Wang L,Li X,Geng J</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34163310"> <div itemprop="name">Exposure to Low to Moderate Doses of Ionizing Radiation Induces A Reduction of Pro-Inflammatory Ly6chigh Monocytes and a U-Curved Response of T Cells in APOE -/- Mice.</div> </a> <div itemprop="about">Dose-response : a publication of International Hormesis Society</div> <div itemprop="author">Rey N,Ebrahimian T,Gloaguen C,Kereselidze D,Magneron V,Bontemps CA,Demarquay C,Olsson G,Haghdoost S,Lehoux S,Ebrahimian TG</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to investigate the immunomodulatory response of different doses and dose-rates of irradiation in ApoE-/- mice.</div> <div itemprodp="datePublished">Fri Jun 25 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33462142"> <div itemprop="name">Estrogen receptor beta signaling in CD8<sup>+</sup> T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Yuan B,Clark CA,Wu B,Yang J,Drerup JM,Li T,Jin VX,Hu Y,Curiel TJ,Li R</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33912169"> <div itemprop="name">Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 20 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34835178"> <div itemprop="name">Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.</div> </a> <div itemprop="about">Vaccines</div> <div itemprop="author">Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Oct 27 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33547083"> <div itemprop="name">A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Steinbuck MP,Seenappa LM,Jakubowski A,McNeil LK,Haqq CM,DeMuth PC</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34025677"> <div itemprop="name">IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells <i>via</i> Aryl Hydrocarbon Receptor Activation.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Oct 29 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33637123"> <div itemprop="name">Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.</div> </a> <div itemprop="about">Stem cell research & therapy</div> <div itemprop="author">Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Feb 26 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34103476"> <div itemprop="name">G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Sun SN,Ni SH,Li Y,Liu X,Deng JP,Chen ZX,Li H,Feng WJ,Huang YS,Li DN,Xian SX,Yang ZQ,Wang LJ,Lu L</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 08 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33803282"> <div itemprop="name">Butyrate Improves Skin/Lung Fibrosis and Intestinal Dysbiosis in Bleomycin-Induced Mouse Models.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Park HJ,Jeong OY,Chun SH,Cheon YH,Kim M,Kim S,Lee SI</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Mar 09 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34003838"> <div itemprop="name">Mapping Rora expression in resting and activated CD4+ T cells.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Haim-Vilmovsky L,Henriksson J,Walker JA,Miao Z,Natan E,Kar G,Clare S,Barlow JL,Charidemou E,Mamanova L,Chen X,Proserpio V,Pramanik J,Woodhouse S,Protasio AV,Efremova M,Griffin JL,Berriman M,Dougan G,Fisher J,Marioni JC,McKenzie ANJ,Teichmann SA</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Nov 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34487763"> <div itemprop="name">Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34638503"> <div itemprop="name">Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 07 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34638503"> <div itemprop="name">Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 07 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34593794"> <div itemprop="name">A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 30 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34593794"> <div itemprop="name">A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 30 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33643804"> <div itemprop="name">Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33643804"> <div itemprop="name">Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33922052"> <div itemprop="name">Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Santos J,Heiniö C,Quixabeira D,Zafar S,Clubb J,Pakola S,Cervera-Carrascon V,Havunen R,Kanerva A,Hemminki A</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 22 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34373759"> <div itemprop="name">Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.</div> </a> <div itemprop="about">Theranostics</div> <div itemprop="author">Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 28 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34373759"> <div itemprop="name">Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.</div> </a> <div itemprop="about">Theranostics</div> <div itemprop="author">Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 28 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34925367"> <div itemprop="name">Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 14 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34726065"> <div itemprop="name">Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.</div> </a> <div itemprop="about">Journal of the American Heart Association</div> <div itemprop="author">Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 16 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34726065"> <div itemprop="name">Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.</div> </a> <div itemprop="about">Journal of the American Heart Association</div> <div itemprop="author">Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 16 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34283811"> <div itemprop="name">TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">de Mattos Barbosa MG,Lefferts AR,Huynh D,Liu H,Zhang Y,Fu B,Barnes J,Samaniego M,Bram RJ,Geha RS,Shikanov A,Prak ETL,Farkash EA,Platt JL,Cascalho M</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Sep 08 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33916809"> <div itemprop="name">Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Sat Apr 03 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33916809"> <div itemprop="name">Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Sat Apr 03 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34185423"> <div itemprop="name">Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.</div> </a> <div itemprop="about">Clinical and translational medicine</div> <div itemprop="author">Cheng CS,Tan HY,Wang N,Chen L,Meng Z,Chen Z,Feng Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34815397"> <div itemprop="name">G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N</div> <div itemprop="description">11-0041-82 was used in Flow cytometry/Cell sorting to show that in mice lacking P2Y10 in the CD4 T cell compartment, the severity of experimental autoimmune encephalomyelitis and cutaneous contact hypersensitivity is reduced.</div> <div itemprodp="datePublished">Tue Nov 23 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33394045"> <div itemprop="name">Investigating the Mechanism of Trimethoprim-Induced Skin Rash and Liver Injury.</div> </a> <div itemprop="about">Toxicological sciences : an official journal of the Society of Toxicology</div> <div itemprop="author">Cao Y,Bairam A,Jee A,Liu M,Uetrecht J</div> <div itemprop="description">11-0041-82 was used in Flow cytometry/Cell sorting to provide important data required to understand the mechanism of TMP-induced skin rash and drug-induced skin rash in general.</div> <div itemprodp="datePublished">Fri Feb 26 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33692790"> <div itemprop="name">Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34944584"> <div itemprop="name">Intravesical High Dose BCG Tokyo and Low Dose BCG Tokyo with <i>GMCSF+IFN α</i> Induce Systemic Immunity in a Murine Orthotopic Bladder Cancer Model.</div> </a> <div itemprop="about">Biomedicines</div> <div itemprop="author">Tham SM,Rahmat JN,Chiong E,Wu Q,Esuvaranathan K,Mahendran R</div> <div itemprop="description">11-0041-82 was used in Flow cytometry/Cell sorting to evaluate a short therapy schedule for bladder cancer using BCG Tokyo. BCG Tokyo was evaluated in vitro using bone marrow derived dendritic cells, neutrophils, RAW macrophages and the murine bladder cancer cell line, MB49PSA, and compared to other BCG strains.</div> <div itemprodp="datePublished">Thu Nov 25 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33951438"> <div itemprop="name">Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Vaena S,Chakraborty P,Lee HG,Janneh AH,Kassir MF,Beeson G,Hedley Z,Yalcinkaya A,Sofi MH,Li H,Husby ML,Stahelin RV,Yu XZ,Mehrotra S,Ogretmen B</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Tue May 04 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32661390"> <div itemprop="name">Myocardial infarction accelerates breast cancer via innate immune reprogramming.</div> </a> <div itemprop="about">Nature medicine</div> <div itemprop="author">Koelwyn GJ,Newman AAC,Afonso MS,van Solingen C,Corr EM,Brown EJ,Albers KB,Yamaguchi N,Narke D,Schlegel M,Sharma M,Shanley LC,Barrett TJ,Rahman K,Mezzano V,Fisher EA,Park DS,Newman JD,Quail DF,Nelson ER,Caan BJ,Jones LW,Moore KJ</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that myocardial infarction (MI) accelerates breast cancer outgrowth and cancer-specific mortality in mice and humans. I.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32758418"> <div itemprop="name">The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Kitamoto S,Nagao-Kitamoto H,Jiao Y,Gillilland MG,Hayashi A,Imai J,Sugihara K,Miyoshi M,Brazil JC,Kuffa P,Hill BD,Rizvi SM,Wen F,Bishu S,Inohara N,Eaton KA,Nusrat A,Lei YL,Giannobile WV,Kamada N</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to conclude that oral inflammation, such as periodontitis, exacerbates gut inflammation by supplying the gut with both colitogenic pathobionts and pathogenic T cells.</div> <div itemprodp="datePublished">Thu Jul 23 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33220234"> <div itemprop="name">Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 15 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32126289"> <div itemprop="name">Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells.</div> </a> <div itemprop="about">Brain, behavior, and immunity</div> <div itemprop="author">Piras G,Rattazzi L,Paschalidis N,Oggero S,Berti G,Ono M,Bellia F,D'Addario C,Dell'Osso B,Pariante CM,Perretti M,D'Acquisto F</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to identify a novel factor, a small protein of approximately 21 kDa encoded by the gene 2610019F03Rik, thus named Immuno-moodulin, associated with overexpressing Annexin-A1 exclusively in T cells, as a novel peripheral determinant that modulates anxiety behavior.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32658456"> <div itemprop="name">Splenic Capture and <i>In Vivo</i> Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets.</div> </a> <div itemprop="about">ACS nano</div> <div itemprop="author">Newman L,Jasim DA,Prestat E,Lozano N,de Lazaro I,Nam Y,Assas BM,Pennock J,Haigh SJ,Bussy C,Kostarelos K</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Aug 25 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31886826"> <div itemprop="name">Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Kang YA,Pietras EM,Passegué E</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Mar 02 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32133635"> <div itemprop="name">Critical role of OX40 in drug-induced acute liver injury.</div> </a> <div itemprop="about">British journal of pharmacology</div> <div itemprop="author">Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33370418"> <div itemprop="name">Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Akhtar MN,Mishra M,Yadav V,Yadav M,Gujar R,Lal S,Kumar R,Khatri N,Sen P</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32555509"> <div itemprop="name">Free fatty acid receptor 4 (FFA4) activation ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by increasing regulatory T cells in mice.</div> </a> <div itemprop="about">Acta pharmacologica Sinica</div> <div itemprop="author">Son SE,Park SJ,Koh JM,Im DS</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show the activation of FFA4 ameliorates atopic dermatitis.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31782262"> <div itemprop="name">Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Wu R,Liu C,Deng X,Chen L,Hao S,Ma L</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33124760"> <div itemprop="name">DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33124760"> <div itemprop="name">DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32368288"> <div itemprop="name">HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.</div> </a> <div itemprop="about">Journal of Cancer</div> <div itemprop="author">Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32319625"> <div itemprop="name">Effects of combined treatment with PD‑L1 Ig and CD40L mAb on immune tolerance in the CBA/J x DBA/2 mouse model.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Li G,Yang L,Li D,Zhang J,Du L,Xia L,Liu Y,Hu W</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31746428"> <div itemprop="name">IDO inhibitor synergized with radiotherapy to delay tumor growth by reversing T cell exhaustion.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Liu M,Li Z,Yao W,Zeng X,Wang L,Cheng J,Ma B,Zhang R,Min W,Wang H</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to investigate whether an iindoleamine 2,3‚dioxygenase (IDO) inhibitor synergized with radiotherapy (RT) can further inhibit tumor growth.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32332708"> <div itemprop="name">FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 24 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32549755"> <div itemprop="name">Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.</div> </a> <div itemprop="about">International journal of biological sciences</div> <div itemprop="author">Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Nov 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32549755"> <div itemprop="name">Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.</div> </a> <div itemprop="about">International journal of biological sciences</div> <div itemprop="author">Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Nov 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32545199"> <div itemprop="name">Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Yoon CH,Ryu JS,Hwang HS,Kim MK</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 11 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32927737"> <div itemprop="name">Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Martinikova AS,Burocziova M,Stoyanov M,Macurek L</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 10 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32927737"> <div itemprop="name">Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Martinikova AS,Burocziova M,Stoyanov M,Macurek L</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 10 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32274314"> <div itemprop="name">Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32274314"> <div itemprop="name">Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32814714"> <div itemprop="name">Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 20 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32332858"> <div itemprop="name">Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.</div> </a> <div itemprop="about">Communications biology</div> <div itemprop="author">Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 24 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32861243"> <div itemprop="name">CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Chen YQ,Wang SN,Shi YJ,Chen J,Ding SQ,Tang J,Shen L,Wang R,Ding H,Hu JG,Lü HZ</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the effect of CRID3 on the local microenvironment and the possible role in neuroprotection following spinal cord injury.</div> <div itemprodp="datePublished">Sat Aug 29 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33051000"> <div itemprop="name">Critical role of WNK1 in MYC-dependent early mouse thymocyte development.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to ind that WNK1 is required for the transition of double negative (DN) thymocytes through the β-selection checkpoint and subsequent proliferation and differentiation into double positive (DP) thymocytes.</div> <div itemprodp="datePublished">Wed Oct 14 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33270017"> <div itemprop="name">BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Li J,Zhang L,Zheng Y,Shao R,Liang Q,Yu W,Wang H,Zou W,Wang D,Xiang J,Lin A</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to put forward a model in which inactivation of BAD confers the apoptosis resistance on synovial sublining macrophages, thereby contributing to the development of arthritis, suggesting that BAD may be a potential therapeutic target for RA.</div> <div itemprodp="datePublished">Thu Dec 03 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32579916"> <div itemprop="name">CD8<sup>+</sup> T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Kinder JM,Turner LH,Stelzer IA,Miller-Handley H,Burg A,Shao TY,Pham G,Way SS</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to demonstrate distinct mechanisms whereby fetal tolerance is maintained during primary compared with subsequent pregnancies.</div> <div itemprodp="datePublished">Tue Jun 23 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33383959"> <div itemprop="name">The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Subbannayya Y,Haug M,Pinto SM,Mohanty V,Meås HZ,Flo TH,Prasad TSK,Kandasamy RK</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 29 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31981455"> <div itemprop="name">MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma.</div> </a> <div itemprop="about">Aging</div> <div itemprop="author">Liu Z,Wen J,Wu C,Hu C,Wang J,Bao Q,Wang H,Wang J,Zhou Q,Wei L,Shen Y,Zhang W</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to provide important and novel insight into a regulatory axis involving microRNA-200a/PTEN/ PD-L1 axis, which determines osteosarcoma growth and the efficacy of PD-L1-targeted immunotherapy.</div> <div itemprodp="datePublished">Fri Jan 24 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32160545"> <div itemprop="name">ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Viaud M,Abdel-Wahab O,Gall J,Ivanov S,Guinamard R,Sore S,Merlin J,Ayrault M,Guilbaud E,Jacquel A,Auberger P,Wang N,Levine RL,Tall AR,Yvan-Charvet L</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to identify somatic mutations in ABCA1 that subvert its anti-proliferative and cholesterol efflux functions and permit the progression of myeloid neoplasms.</div> <div itemprodp="datePublished">Tue Mar 10 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32970735"> <div itemprop="name">ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Nov 16 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32601347"> <div itemprop="name">Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 29 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33362775"> <div itemprop="name">Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 21 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33362775"> <div itemprop="name">Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 21 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31142833"> <div itemprop="name">Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30770250"> <div itemprop="name">A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Minutti CM,Modak RV,Macdonald F,Li F,Smyth DJ,Dorward DA,Blair N,Husovsky C,Muir A,Giampazolias E,Dobie R,Maizels RM,Kendall TJ,Griggs DW,Kopf M,Henderson NC,Zaiss DM</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to identify macrophages as a critical source of Amphiregulin, revealing a direct effector mechanism by which these cells contribute to tissue restoration after acute injury.</div> <div itemprodp="datePublished">Tue Mar 19 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30620726"> <div itemprop="name">Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Soukup AA,Zheng Y,Mehta C,Wu J,Liu P,Cao M,Hofmann I,Zhou Y,Zhang J,Johnson KD,Choi K,Keles S,Bresnick EH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the mechanisms underlying how GATA2 enhancer disease mutations impact hematopoiesis and pathology.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30633890"> <div itemprop="name">T helper 2 differentiation is necessary for development of lymphedema.</div> </a> <div itemprop="about">Translational research : the journal of laboratory and clinical medicine</div> <div itemprop="author">Ly CL,Nores GDG,Kataru RP,Mehrara BJ</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to analyse the effect of lymphatic injury in transgenic mice with mutations that cause defects in Th1 and Th2 cell generation (T-bet knockout or T-betKO and STAT6 knockout or STAT6KO mice, respectively).</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30628173"> <div itemprop="name">Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer.</div> </a> <div itemprop="about">Molecular oncology</div> <div itemprop="author">Zhou Z,Chen H,Xie R,Wang H,Li S,Xu Q,Xu N,Cheng Q,Qian Y,Huang R,Shao Z,Xiang M</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that upregulation of FOXM1 by H3K79me2 in pancreatic cancer and colon cancer significantly inhibits maturation phenotypes and function of bone marrow dendritic cells (BMDCs) through the Wnt5a signaling pathway, and thus provide novel insights into FOXM1-based antitumor immunotherapy.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30612460"> <div itemprop="name">Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance.</div> </a> <div itemprop="about">The American journal of Chinese medicine</div> <div itemprop="author">Li Q,Shan Q,Sang X,Zhu R,Chen X,Cao G</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of total glycoside of peony on experimental colitis mice.</div> <div itemprodp="datePublished">Fri Mar 15 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30353130"> <div itemprop="name">Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.</div> </a> <div itemprop="about">Laboratory investigation; a journal of technical methods and pathology</div> <div itemprop="author">Hensel JA,Khattar V,Ashton R,Ponnazhagan S</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31243090"> <div itemprop="name">Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E<sub>2</sub>.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Liu T,Yang Q,Cao YJ,Yuan WM,Lei AH,Zhou P,Zhou W,Liu YD,Shi MH,Yang Q,Tang JY,Wang HK,Zhang H,Yu Y,Zhou J</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to indicate that COX-1 plays an important role in the development of TFH cells.</div> <div itemprodp="datePublished">Thu Aug 15 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31251471"> <div itemprop="name">Bryostatin-1 ameliorated experimental colitis in Il-10<sup>-/-</sup> Mice by protecting the intestinal barrier and limiting immune dysfunction.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Zuo L,Li J,Ge S,Ge Y,Shen M,Wang Y,Zhou C,Wu R,Hu J</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31251471"> <div itemprop="name">Bryostatin-1 ameliorated experimental colitis in Il-10<sup>-/-</sup> Mice by protecting the intestinal barrier and limiting immune dysfunction.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Zuo L,Li J,Ge S,Ge Y,Shen M,Wang Y,Zhou C,Wu R,Hu J</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31321013"> <div itemprop="name"><i>Lactobacillus rhamnosus</i> GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice <i>via</i> gut-microbiota-dependent anti-inflammation.</div> </a> <div itemprop="about">Therapeutic advances in chronic disease</div> <div itemprop="author">Liu H,Gu R,Li W,Zhou W,Cong Z,Xue J,Liu Y,Wei Q,Zhou Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Apr 09 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30800002"> <div itemprop="name">Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-<i>β</i>/Smad Signaling Pathway.</div> </a> <div itemprop="about">Mediators of inflammation</div> <div itemprop="author">Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 11 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30647024"> <div itemprop="name">IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.</div> </a> <div itemprop="about">Biology open</div> <div itemprop="author">Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 15 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30998512"> <div itemprop="name">Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.</div> </a> <div itemprop="about">Anti-cancer drugs</div> <div itemprop="author">Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30998512"> <div itemprop="name">Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.</div> </a> <div itemprop="about">Anti-cancer drugs</div> <div itemprop="author">Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31815005"> <div itemprop="name">An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.</div> </a> <div itemprop="about">NPJ vaccines</div> <div itemprop="author">Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31231429"> <div itemprop="name">Next Generation Sequencing for Long Non-coding RNAs Profile for CD4<sup>+</sup> T Cells in the Mouse Model of Acute Asthma.</div> </a> <div itemprop="about">Frontiers in genetics</div> <div itemprop="author">Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30700819"> <div itemprop="name">Sex Differences in Mouse Popliteal Lymph Nodes.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Dill-Garlow R,Chen KE,Walker AM</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jan 30 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31131189"> <div itemprop="name">TLR1/2 Specific Small-Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Cen X,Zhu G,Yang J,Yang J,Guo J,Jin J,Nandakumar KS,Yang W,Yin H,Liu S,Cheng K</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 17 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31167148"> <div itemprop="name">Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Cianciaruso C,Beltraminelli T,Duval F,Nassiri S,Hamelin R,Mozes A,Gallart-Ayala H,Ceada Torres G,Torchia B,Ries CH,Ivanisevic J,De Palma M</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 04 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31086813"> <div itemprop="name">Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating T<sub>reg</sub> cells.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Feng M,Jin JQ,Xia L,Xiao T,Mei S,Wang X,Huang X,Chen J,Liu M,Chen C,Rafi S,Zhu AX,Feng YX,Zhu D</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to develop potent, selective inhibitors targeting the Wnt/B catenin pathway.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30823934"> <div itemprop="name">Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Quan MY,Song XJ,Liu HJ,Deng XH,Hou HQ,Chen LP,Ma TZ,Han X,He XX,Jia Z,Guo L</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to study the effect of ALX on the maturation of dendritic cells and the responses of effector and regulatory T cells.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31645712"> <div itemprop="name">Epithelial EP4 plays an essential role in maintaining homeostasis in colon.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Matsumoto Y,Nakanishi Y,Yoshioka T,Yamaga Y,Masuda T,Fukunaga Y,Sono M,Yoshikawa T,Nagao M,Araki O,Ogawa S,Goto N,Hiramatsu Y,Breyer RM,Fukuda A,Seno H</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Oct 23 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31607947"> <div itemprop="name">The IRE1α Arm of UPR Regulates Muscle Cells Immune Characters by Restraining p38 MAPK Activation.</div> </a> <div itemprop="about">Frontiers in physiology</div> <div itemprop="author">Gu R,Huang T,Xiao J,Liao Z,Li J,Lan H,Ouyang J,Hu J,Liao H</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to demonstrate that p38 MAPK contributes greatly to IRE1α arm-dependent immunobiological suppression in myocytes under inflammatory stress conditions.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31474984"> <div itemprop="name">MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Demeyer A,Skordos I,Driege Y,Kreike M,Hochepied T,Baens M,Staal J,Beyaert R</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to establish that suppression of autoimmune responses is due to the T-cell intrinsic role of MALT1 proteolytic activity.</div> <div itemprodp="datePublished">Mon Oct 05 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30949049"> <div itemprop="name">The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis.</div> </a> <div itemprop="about">Frontiers in pharmacology</div> <div itemprop="author">Hansel C,Erschfeld S,Baues M,Lammers T,Weiskirchen R,Trautwein C,Kroy DC,Drescher HK</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the expression profile of inhibitory T cell receptors on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31354740"> <div itemprop="name">Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to indicate that CFH, through its function as a complement repressor, acts as a negative regulator of BCR signaling and limits autoimmunity.</div> <div itemprodp="datePublished">Tue Oct 13 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29907525"> <div itemprop="name">Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Halim TYF,Rana BMJ,Walker JA,Kerscher B,Knolle MD,Jolin HE,Serrao EM,Haim-Vilmovsky L,Teichmann SA,Rodewald HR,Botto M,Vyse TJ,Fallon PG,Li Z,Withers DR,McKenzie ANJ</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 19 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29452935"> <div itemprop="name">E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC</div> <div itemprop="description">11-0041 was used in Immunohistochemistry to indicate that the VHL-HIF-glycolysis axis is essential for the late-stage maturation and function of ILC2s via targeting IL-33-ST2 pathway.</div> <div itemprodp="datePublished">Tue Feb 20 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29456159"> <div itemprop="name">CD150<sup>high</sup> Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Hirata Y,Furuhashi K,Ishii H,Li HW,Pinho S,Ding L,Robson SC,Frenette PS,Fujisaki J</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment.</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29528335"> <div itemprop="name">Insulin resistance causes inflammation in adipose tissue.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to elucidate the causal relationship between obesity-induced insulin resistance, and macrophage accumulation and inflammation in adipose tissue.</div> <div itemprodp="datePublished">Mon Apr 02 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29688896"> <div itemprop="name">Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 02 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29563320"> <div itemprop="name">An OX40/OX40L interaction directs successful immunity to hepatitis B virus.</div> </a> <div itemprop="about">Science translational medicine</div> <div itemprop="author">Publicover J,Gaggar A,Jespersen JM,Halac U,Johnson AJ,Goodsell A,Avanesyan L,Nishimura SL,Holdorf M,Mansfield KG,Judge JB,Koshti A,Croft M,Wakil AE,Rosenthal P,Pai E,Cooper S,Baron JL</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the mechanistic action of the immune pathways and cells necessary for HBV immunity and identify potential therapeutic targets for resolving chronic HBV infection.</div> <div itemprodp="datePublished">Wed Mar 21 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29514845"> <div itemprop="name">PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell-Driven Antitumor Immunity.</div> </a> <div itemprop="about">Clinical cancer research : an official journal of the American Association for Cancer Research</div> <div itemprop="author">Buchan SL,Fallatah M,Thirdborough SM,Taraban VY,Rogel A,Thomas LJ,Penfold CA,He LZ,Curran MA,Keler T,Al-Shamkhani A</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that suboptimal T-cell invigoration in cancer patients undergoing treatment with PD-1 checkpoint blockers will be improved by dual PD-1 blockade and CD27 agonism.</div> <div itemprodp="datePublished">Tue May 15 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29478729"> <div itemprop="name">Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.</div> </a> <div itemprop="about">Molecular therapy : the journal of the American Society of Gene Therapy</div> <div itemprop="author">Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Apr 04 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29740426"> <div itemprop="name">Multipotent Adult Progenitor Cells Suppress T Cell Activation in <i>In Vivo</i> Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Carty F,Corbett JM,Cunha JPMCM,Reading JL,Tree TIM,Ting AE,Stubblefield SR,English K</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate, using a mouse model of homeostatic proliferation, the immunosuppressive properties of multipotent adult progenitor cells, through their ability to control T cell proliferation.</div> <div itemprodp="datePublished">Tue Jun 25 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29867949"> <div itemprop="name">NH36 and F3 Antigen-Primed Dendritic Cells Show Preserved Migrating Capabilities and CCR7 Expression and F3 Is Effective in Immunotherapy of Visceral Leishmaniasis.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Nico D,Martins Almeida F,Maria Motta J,Soares Dos Santos Cardoso F,Freire-de-Lima CG,Freire-de-Lima L,de Luca PM,Maria Blanco Martinez A,Morrot A,Palatnik-de-Sousa CB</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to assess whether NH36 or the F3 peptide are capable of preventing the migrating effect of dendritic cells by restoring the expression of CCR7 receptors.</div> <div itemprodp="datePublished">Thu Jul 11 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30080893"> <div itemprop="name">A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Leoni V,Vannini A,Gatta V,Rambaldi J,Sanapo M,Barboni C,Zaghini A,Nanni P,Lollini PL,Casiraghi C,Campadelli-Fiume G</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to analyse the efficacy of a fully-virulent HER2-retargeted oncolytic HSV, demonstrating its ability to elicit a local immune response and systemic therapy vaccine effects.</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28987000"> <div itemprop="name">MicroRNA-126 deficiency enhanced the activation and function of CD4<sup>+</sup> T cells by elevating IRS-1 pathway.</div> </a> <div itemprop="about">Clinical and experimental immunology</div> <div itemprop="author">Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30065558"> <div itemprop="name">Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.</div> </a> <div itemprop="about">World journal of gastroenterology</div> <div itemprop="author">Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jul 28 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30065558"> <div itemprop="name">Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.</div> </a> <div itemprop="about">World journal of gastroenterology</div> <div itemprop="author">Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jul 28 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30065558"> <div itemprop="name">Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.</div> </a> <div itemprop="about">World journal of gastroenterology</div> <div itemprop="author">Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jul 28 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29681974"> <div itemprop="name">Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.</div> </a> <div itemprop="about">Evidence-based complementary and alternative medicine : eCAM</div> <div itemprop="author">Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30457103"> <div itemprop="name">A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 20 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30241479"> <div itemprop="name">Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Sep 21 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30254309"> <div itemprop="name">Plasmodium co-infection protects against chikungunya virus-induced pathologies.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Teo TH,Lum FM,Ghaffar K,Chan YH,Amrun SN,Tan JJL,Lee CYP,Chua TK,Carissimo G,Lee WWL,Claser C,Rajarethinam R,Rénia L,Ng LFP</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 25 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30373602"> <div itemprop="name">Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.</div> </a> <div itemprop="about">Journal of experimental & clinical cancer research : CR</div> <div itemprop="author">Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of the flavonoid apigenin on the PD-L1 expression and the tumourigenesis of melanoma.</div> <div itemprodp="datePublished">Mon Oct 29 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30373602"> <div itemprop="name">Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.</div> </a> <div itemprop="about">Journal of experimental & clinical cancer research : CR</div> <div itemprop="author">Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of the flavonoid apigenin on the PD-L1 expression and the tumourigenesis of melanoma.</div> <div itemprodp="datePublished">Mon Oct 29 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29500416"> <div itemprop="name">Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 02 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30089711"> <div itemprop="name">Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 09 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29773802"> <div itemprop="name">CD4<sup>+</sup> T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">García Nores GD,Ly CL,Cuzzone DA,Kataru RP,Hespe GE,Torrisi JS,Huang JJ,Gardenier JC,Savetsky IL,Nitti MD,Yu JZ,Rehal S,Mehrara BJ</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate that blocking T cell release from lymph nodes using a sphingosine-1-phosphate receptor modulator prevents lymphedema.</div> <div itemprodp="datePublished">Thu May 17 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30198844"> <div itemprop="name">Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 10 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30375383"> <div itemprop="name">SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Singh AK,Khare P,Obaid A,Conlon KP,Basrur V,DePinho RA,Venuprasad K</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to define the molecular mechanisms that govern the transcription factor activity of ROR-γt in the regulation of IL-17.</div> <div itemprodp="datePublished">Tue Oct 30 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29897995"> <div itemprop="name">Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Arai S,Iwabuchi N,Takahashi S,Xiao JZ,Abe F,Hachimura S</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of orally administered heat-killed MCC1849 on IgA production in the intestine and on Tfh cell induction in vivo.</div> <div itemprodp="datePublished">Wed Jan 02 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29670088"> <div itemprop="name">A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Apr 18 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29876215"> <div itemprop="name">Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Peng J,Xiao Y,Li W,Yang Q,Tan L,Jia Y,Qu Y,Qian Z</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30013024"> <div itemprop="name">Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b.</div> <div itemprodp="datePublished">Mon Jul 16 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30093899"> <div itemprop="name"><i>Trichinella spiralis</i> Infection Mitigates Collagen-Induced Arthritis <i>via</i> Programmed Death 1-Mediated Immunomodulation.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Cheng Y,Zhu X,Wang X,Zhuang Q,Huyan X,Sun X,Huang J,Zhan B,Zhu X</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to introduce the first evidence that PD-1 plays a critical role in Trichinella spiralis infection-attenuated collagen-induced arthritis in a mouse model by regulating the CD4+ T cell function, which may provide the new insights into the mechanisms of helminth-induced immunomodulation of host autoimmunity.</div> <div itemprodp="datePublished">Mon Jan 28 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29925006"> <div itemprop="name">Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to examine the role of Notch signalling in the in vitro generation of classical dendritic cells.</div> <div itemprodp="datePublished">Tue Jun 19 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30566866"> <div itemprop="name">The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Li S,Hong Z,Wang Z,Li F,Mei J,Huang L,Lou X,Zhao S,Song L,Chen W,Wang Q,Liu H,Cai Y,Yu H,Xu H,Zeng G,Wang Q,Zhu J,Liu X,Tan N,Wang C</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to characterise a STING-specific small-molecular inhibitor that may be applied for potentially manipulating the STING-mediated clinical diseases.</div> <div itemprodp="datePublished">Tue Dec 18 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29483875"> <div itemprop="name">Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.</div> </a> <div itemprop="about">Frontiers in physiology</div> <div itemprop="author">Lim D,Kim W,Lee C,Bae H,Kim J</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29946143"> <div itemprop="name">In utero nanoparticle delivery for site-specific genome editing.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ricciardi AS,Bahal R,Farrelly JS,Quijano E,Bianchi AH,Luks VL,Putman R,López-Giráldez F,Coşkun S,Song E,Liu Y,Hsieh WC,Ly DH,Stitelman DH,Glazer PM,Saltzman WM</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate the safe intravenous and intra-amniotic administration of polymeric nanoparticles to foetal mouse tissues at selected gestational ages with no effect on survival or postnatal growth.</div> <div itemprodp="datePublished">Tue Jun 26 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30451821"> <div itemprop="name">Sumoylation of RORγt regulates T<sub>H</sub>17 differentiation and thymocyte development.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">He Z,Zhang J,Huang Z,Du Q,Li N,Zhang Q,Chen Y,Sun Z</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the mechanism underlying the regulation of RORyt function.</div> <div itemprodp="datePublished">Mon Nov 19 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29299532"> <div itemprop="name">Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.</div> </a> <div itemprop="about">mSphere</div> <div itemprop="author">Quach D,Collins F,Parameswaran N,McCabe L,Britton RA</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Nov 20 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29650963"> <div itemprop="name">Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Li H,Yao Q,Mariscal AG,Wu X,Hülse J,Pedersen E,Helin K,Waisman A,Vinkel C,Thomsen SF,Avgustinova A,Benitah SA,Lovato P,Norsgaard H,Mortensen MS,Veng L,Rozell B,Brakebusch C</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile in mice.</div> <div itemprodp="datePublished">Thu Apr 12 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29314730"> <div itemprop="name">Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.</div> </a> <div itemprop="about">Immunity, inflammation and disease</div> <div itemprop="author">Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and 3.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29030115"> <div itemprop="name">Store-Operated Ca<sup>2+</sup> Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 17 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28399409"> <div itemprop="name">Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo.</div> </a> <div itemprop="about">Cancer cell</div> <div itemprop="author">Leanza L,Romio M,Becker KA,Azzolini M,Trentin L,Managò A,Venturini E,Zaccagnino A,Mattarei A,Carraretto L,Urbani A,Kadow S,Biasutto L,Martini V,Severin F,Peruzzo R,Trimarco V,Egberts JH,Hauser C,Visentin A,Semenzato G,Kalthoff H,Zoratti M,Gulbins E,Paradisi C,Szabo I</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate that specific pharmacological targeting of a mitochondrial potassium channel can lead to reactive oxygen species-mediated selective apoptosis of cancer cells in vivo, without significant side effects.</div> <div itemprodp="datePublished">Mon Apr 10 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28363640"> <div itemprop="name">Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.</div> </a> <div itemprop="about">Gastroenterology</div> <div itemprop="author">King A,Houlihan DD,Kavanagh D,Haldar D,Luu N,Owen A,Suresh S,Than NN,Reynolds G,Penny J,Sumption H,Ramachandran P,Henderson NC,Kalia N,Frampton J,Adams DH,Newsome PN</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the role of sphingosine-1-phosphate in the response of hematopoietic stem cells to liver fibrosis in mice.</div> <div itemprodp="datePublished">Sat Jul 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29174402"> <div itemprop="name">Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria.</div> </a> <div itemprop="about">Cell host & microbe</div> <div itemprop="author">Jiang TT,Shao TY,Ang WXG,Kinder JM,Turner LH,Pham G,Whitt J,Alenghat T,Way SS</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that commensal fungi can functionally replace intestinal bacteria by conferring protection against injury to mucosal tissues and positively calibrating the responsiveness of circulating immune cells.</div> <div itemprodp="datePublished">Wed Dec 13 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28134623"> <div itemprop="name">A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28487311"> <div itemprop="name">Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 05 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28787589"> <div itemprop="name">GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.</div> </a> <div itemprop="about">Developmental cell</div> <div itemprop="author">Hewitt KJ,Katsumura KR,Matson DR,Devadas P,Tanimura N,Hebert AS,Coon JJ,Kim JS,Dewey CN,Keles S,Hao S,Paulson RF,Bresnick EH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to propose that Samd14-Enh and an ensemble of anemia-responsive enhancers are essential for erythrocyte regeneration in stress erythropoiesis.</div> <div itemprodp="datePublished">Mon Aug 07 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28923858"> <div itemprop="name">Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28566332"> <div itemprop="name">Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jul 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28270614"> <div itemprop="name">Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Mar 21 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27834952"> <div itemprop="name">Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b<sup>+</sup>Ly6G<sup>+</sup> intratumor myeloid cells through the TICAM-1 signaling pathway.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Shime H,Matsumoto M,Seya T</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28642246"> <div itemprop="name">Modulation of Endoplasmic Reticulum Stress Controls CD4<sup>+</sup> T-cell Activation and Antitumor Function.</div> </a> <div itemprop="about">Cancer immunology research</div> <div itemprop="author">Thaxton JE,Wallace C,Riesenberg B,Zhang Y,Paulos CM,Beeson CC,Liu B,Li Z</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate whether the endoplasmic reticulum stress response may be important for CD4+ T-cell activation and whether gp96 is integral to this process.</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28963139"> <div itemprop="name">PI3Kγ Activates Integrin α<sub>4</sub> and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression.</div> </a> <div itemprop="about">Cancer immunology research</div> <div itemprop="author">Foubert P,Kaneda MM,Varner JA</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to highlight PI3Kγ and integrin α4 as targets for the design of cancer therapeutics.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28747917"> <div itemprop="name">Upregulation of Intestinal Barrier Function in Mice with DSS-Induced Colitis by a Defined Bacterial Consortium Is Associated with Expansion of IL-17A Producing Gamma Delta T Cells.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Li M,Wang B,Sun X,Tang Y,Wei X,Ge B,Tang Y,Deng Y,He C,Yuan J,Li X</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate bacterial consortium transplantation as a treatment for IBD, showing an upregulation of intestinal barrier function associated with expansion of IL-17A producing gamma delta T cells.</div> <div itemprodp="datePublished">Wed Nov 20 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28736556"> <div itemprop="name">Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced Arthritis <i>via</i> Targeting Pathogenic Antigen-Specific Th17-Type Cells.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Zayoud M,Marcu-Malina V,Vax E,Jacob-Hirsch J,Elad-Sfadia G,Barshack I,Kloog Y,Goldstein I</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to test the therapeutic and immunomodulatory effects of farnesylthiosalicylic acid and its derivative 5-fluoro-FTS in the rat adjuvant-induced arthritis model.</div> <div itemprodp="datePublished">Wed Nov 20 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28968468"> <div itemprop="name">IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Valanparambil RM,Tam M,Gros PP,Auger JP,Segura M,Gros P,Jardim A,Geary TG,Ozato K,Stevenson MM</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the role of interferon regulatory factor-8 on Th2 immunity to Helimosomoides polygyrus bakeri infection.</div> <div itemprodp="datePublished">Sun Oct 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28676836"> <div itemprop="name">Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH.</div> </a> <div itemprop="about">Oxidative medicine and cellular longevity</div> <div itemprop="author">Ramadori P,Drescher H,Erschfeld S,Fragoulis A,Kensler TW,Wruck CJ,Cubero FJ,Trautwein C,Streetz KL,Kroy DC</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to elucidate the effect of Nrf2 overactivation on cellular events in c-met deficient hepatocytes.</div> <div itemprodp="datePublished">Wed Jan 31 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27796295"> <div itemprop="name">Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.</div> </a> <div itemprop="about">Acta pharmacologica Sinica</div> <div itemprop="author">Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27515950"> <div itemprop="name">CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells.</div> </a> <div itemprop="about">Journal of leukocyte biology</div> <div itemprop="author">Myles IA,Zhao M,Nardone G,Olano LR,Reckhow JD,Saleem D,Break TJ,Lionakis MS,Myers TG,Gardina PJ,Kirkpatrick CH,Holland SM,Datta SK</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that extracts from antigen-targeted T cells enhance immunity to Staphylococcus aureus and Candida albicans.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27577867"> <div itemprop="name">Cornea lymphatics drive the CD8<sup>+</sup> T-cell response to herpes simplex virus-1.</div> </a> <div itemprop="about">Immunology and cell biology</div> <div itemprop="author">Gurung HR,Carr MM,Carr DJ</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28724396"> <div itemprop="name">Pathogenic roles of CXCL10 signaling through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis.</div> </a> <div itemprop="about">Arthritis research & therapy</div> <div itemprop="author">Lee JH,Kim B,Jin WJ,Kim HH,Ha H,Lee ZH</div> <div itemprop="description">11-0041 was used in Immunohistochemistry-immunofluorescence to highlight the importance of CXCL10 signaling in the pathogenesis of RA and provide previously unidentified details of the mechanisms by which CXCL10 promotes the development of arthritis.</div> <div itemprodp="datePublished">Wed Jul 19 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27362366"> <div itemprop="name">ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.</div> </a> <div itemprop="about">RNA biology</div> <div itemprop="author">Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu May 04 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28990057"> <div itemprop="name">ID3 may protect mice from anti‑GBM glomerulonephritis by regulating the differentiation of Th17 and Treg cells.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Zhou H,Wang L,Xu Q,Liu Q,Liu H,Qiu W,Hu T,Lv Y,Zhang Q</div> <div itemprop="description"></div> <div itemprodp="datePublished">Fri Dec 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28454333"> <div itemprop="name">A polysaccharide component from <i>Strongylocentrotus nudus</i> eggs inhibited hepatocellular carcinoma in mice by activating T lymphocytes.</div> </a> <div itemprop="about">Oncology letters</div> <div itemprop="author">Zhang M,Liu Y,Li J,Ke M,Yu J,Dou J,Wang H,Zhou C</div> <div itemprop="description"></div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28250928"> <div itemprop="name">Location of tumor affects local and distant immune cell type and number.</div> </a> <div itemprop="about">Immunity, inflammation and disease</div> <div itemprop="author">Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28164040"> <div itemprop="name">TLR2<sup>-/-</sup> Mice Display Increased Clearance of Dermatophyte <i>Trichophyton mentagrophytes</i> in the Setting of Hyperglycemia.</div> </a> <div itemprop="about">Frontiers in cellular and infection microbiology</div> <div itemprop="author">Almeida DF,Fraga-Silva TF,Santos AR,Finato AC,Marchetti CM,Golim MA,Lara VS,Arruda MS,Venturini J</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate that TLR2 diminishes the development of adaptive immune responses during experimental deep dermatophytosis and, in a diabetic scenario, acts to intensify a non-protective inflammatory response.</div> <div itemprodp="datePublished">Mon Sep 18 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29126435"> <div itemprop="name">Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.</div> </a> <div itemprop="about">Stem cell research & therapy</div> <div itemprop="author">Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Nov 10 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28165507"> <div itemprop="name">Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the effect Paeoniflorin has on Th cells and dendritic cells in a mouse MS model.</div> <div itemprodp="datePublished">Mon Feb 06 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28067312"> <div itemprop="name">Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Ai J,Li J,Gessler DJ,Su Q,Wei Q,Li H,Gao G</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence</div> <div itemprodp="datePublished">Mon Jan 09 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28494937"> <div itemprop="name">MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Shigemoto-Kuroda T,Oh JY,Kim DK,Jeong HJ,Park SY,Lee HJ,Park JW,Kim TW,An SY,Prockop DJ,Lee RH</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 09 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29117241"> <div itemprop="name">IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Niikura M,Inoue SI,Mineo S,Asahi H,Kobayashi F</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to explore the role of IFN-γ receptor 1 signalling in placental pathology during severe malaria using luciferase-expressing rodent malaria parasites, P. berghei NK65.</div> <div itemprodp="datePublished">Wed Nov 29 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29375374"> <div itemprop="name">Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells.</div> </a> <div itemprop="about">Frontiers in pharmacology</div> <div itemprop="author">Li M,Gao J,Tang Y,Liu M,Wu S,Qu K,Long X,Li H,Liu M,Liu Y,Yuan J,Mao L,Liu Y,Zheng X,Wang E,Wang J,Yang Y</div> <div itemprop="description"></div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29272319"> <div itemprop="name">Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Min M,Yan BX,Wang P,Landeck L,Chen JQ,Li W,Cai SQ,Zheng M,Man XY</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 16 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28930689"> <div itemprop="name">Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Mehta C,Johnson KD,Gao X,Ong IM,Katsumura KR,McIver SC,Ranheim EA,Bresnick EH</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 19 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28768912"> <div itemprop="name">Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 03 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28197366"> <div itemprop="name">Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28814662"> <div itemprop="name">Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 17 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28194010"> <div itemprop="name">Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 13 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28711483"> <div itemprop="name">A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.</div> </a> <div itemprop="about">EBioMedicine</div> <div itemprop="author">Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28446880"> <div itemprop="name">Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon.</div> </a> <div itemprop="about">Frontiers in physiology</div> <div itemprop="author">Yang T,Ahmari N,Schmidt JT,Redler T,Arocha R,Pacholec K,Magee KL,Malphurs W,Owen JL,Krane GA,Li E,Wang GP,Vickroy TW,Raizada MK,Martyniuk CJ,Zubcevic J</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28165063"> <div itemprop="name">Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Mon Feb 06 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27716507"> <div itemprop="name">Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 06 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27610573"> <div itemprop="name">Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Wang A,Huen SC,Luan HH,Yu S,Zhang C,Gallezot JD,Booth CJ,Medzhitov R</div> <div itemprop="description">11-0041 was used in an ELISA assay to analyse the effects of anorxia in mouse models wih viral and bacterial infections.</div> <div itemprodp="datePublished">Thu Sep 08 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27695003"> <div itemprop="name">Foxp3 and Toll-like receptor signaling balance T<sub>reg</sub> cell anabolic metabolism for suppression.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27881734"> <div itemprop="name">NLRP2 controls age-associated maternal fertility.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Kuchmiy AA,D'Hont J,Hochepied T,Lamkanfi M</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to identify Nlrp2 as a critical regulator of oocyte quality.</div> <div itemprodp="datePublished">Mon Dec 12 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27453063"> <div itemprop="name">CD8<sup>+</sup> T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.</div> </a> <div itemprop="about">Journal of autoimmunity</div> <div itemprop="author">Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27446078"> <div itemprop="name">The Effect of a BSA Conjugate of a Synthetic Hexasaccharide Related to the Fragment of Capsular Polysaccharide of Streptococcus pneumoniae Type 14 on the Activation of Innate and Adaptive Immune Responses.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Akhmatova NK,Kurbatova EA,Akhmatov EA,Egorova NB,Logunov DY,Gening ML,Sukhova EV,Yashunsky DV,Tsvetkov YE,Nifantiev NE</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to evaluate the effects of immunisation with a synthetic hexasaccharide conjugate, with and without an adjuvant, on TLR activation, dendritic cell maturation, and cytokine production in mice.</div> <div itemprodp="datePublished">Fri Jul 22 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27278624"> <div itemprop="name">Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.</div> </a> <div itemprop="about">Immunology</div> <div itemprop="author">Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26471500"> <div itemprop="name">Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.</div> </a> <div itemprop="about">European journal of immunology</div> <div itemprop="author">Venkatasubramanian S,Tripathi D,Tucker T,Paidipally P,Cheekatla S,Welch E,Raghunath A,Jeffers A,Tvinnereim AR,Schechter ME,Andrade BB,Mackman N,Idell S,Vankayalapati R</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to determine the role of tissue factor expressed by myeloid cells during Mycobacterium tuberculosis infection.</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26514620"> <div itemprop="name">p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.</div> </a> <div itemprop="about">European journal of immunology</div> <div itemprop="author">Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26452441"> <div itemprop="name">Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.</div> </a> <div itemprop="about">Clinical and experimental immunology</div> <div itemprop="author">Zhong Y,Tang H,Wang X,Zeng Q,Liu Y,Zhao XI,Yu K,Shi H,Zhu R,Mao X</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the impact of nasal heat shock protein 60 on atherosclerosis and the mechanisms underlying the anti-atherosclerosis responses.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27357149"> <div itemprop="name">Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Menendez CM,Jinkins JK,Carr DJ</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26994219"> <div itemprop="name">Multispectral Imaging of T and B Cells in Murine Spleen and Tumor.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Feng Z,Jensen SM,Messenheimer DJ,Farhad M,Neuberger M,Bifulco CB,Fox BA</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26752353"> <div itemprop="name">Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.</div> </a> <div itemprop="about">Gene therapy</div> <div itemprop="author">Lu G,Teng X,Zheng Z,Zhang R,Peng L,Zheng F,Liu J,Huang H,Xiong H</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the role of Glucokinase in glucose metabolism and assess its potential as a target to treat diabetes.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26752353"> <div itemprop="name">Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.</div> </a> <div itemprop="about">Gene therapy</div> <div itemprop="author">Lu G,Teng X,Zheng Z,Zhang R,Peng L,Zheng F,Liu J,Huang H,Xiong H</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the role of Glucokinase in glucose metabolism and assess its potential as a target to treat diabetes.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27315465"> <div itemprop="name">Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Gu L,Deng WS,Sun XF,Zhou H,Xu Q</div> <div itemprop="description">11-0041 was used in Immunofluorescence to study how rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27106930"> <div itemprop="name">PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.</div> </a> <div itemprop="about">Biology open</div> <div itemprop="author">Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun May 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27416851"> <div itemprop="name">Human embryonic mesenchymal stem cells alleviate pathologic changes of MRL/Lpr mice by regulating Th7 cell differentiation.</div> </a> <div itemprop="about">Renal failure</div> <div itemprop="author">Yuan L,Xiao ZT,Huang XZ,Wu MJ,Shi H,Liu AF</div> <div itemprop="description">11-0041-82 was used in Flow cytometry/Cell sorting to suggest that hMSC therapy could alleviate systemic and local renal lesions in MRL/Lpr mice, probably by secreting immune regulating factors and regulating Th17 cell differentiation in MRL/Lpr mice.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27323847"> <div itemprop="name">Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 21 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27272654"> <div itemprop="name">Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 08 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27441095"> <div itemprop="name"><i>Mycobacterium tuberculosis</i> Induces Expansion of Foxp3 Positive CD4 T-cells with a Regulatory Profile in Tuberculin Non-sensitized Healthy Subjects: Implications for Effective Immunization against TB.</div> </a> <div itemprop="about">Journal of clinical & cellular immunology</div> <div itemprop="author">Hirsch CS,Rojas R,Wu M,Toossi Z</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the basis of iT-reg expansion in response to MTB stimulation, in the absence of prior T cell antigen responsiveness.</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27010503"> <div itemprop="name">The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Braun J,Meixner A,Brachner A,Foisner R</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to test whether ANKLE1 may contribute to Holliday junction resolution during DNA repair in mice.</div> <div itemprodp="datePublished">Fri Aug 12 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27075020"> <div itemprop="name">Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Wang S,Gao X,Shen G,Wang W,Li J,Zhao J,Wei YQ,Edwards CK</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 14 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27222343"> <div itemprop="name">NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed May 25 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27581210"> <div itemprop="name">Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.</div> </a> <div itemprop="about">BMC complementary and alternative medicine</div> <div itemprop="author">Zhang S,Liu X,Mei L,Wang H,Fang F</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Aug 31 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27077112"> <div itemprop="name">CD8(+) T-cell Immune Evasion Enables Oncolytic Virus Immunotherapy.</div> </a> <div itemprop="about">EBioMedicine</div> <div itemprop="author">Pourchet A,Fuhrmann SR,Pilones KA,Demaria S,Frey AB,Mulvey M,Mohr I</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to establish TAP inhibitor-armed OVs that evade CD8(+) T-cells as an immunotherapy strategy to elicit potent anti-tumour responses.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26809474"> <div itemprop="name">MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Ogawa Y,Morikawa S,Okano H,Mabuchi Y,Suzuki S,Yaguchi T,Sato Y,Mukai S,Yaguchi S,Inaba T,Okamoto S,Kawakami Y,Tsubota K,Matsuzaki Y,Shimmura S</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the fibrosis in a scleroderma mouse model which is triggered by antigen mismatched bone marrow stromal/stem cells.</div> <div itemprodp="datePublished">Tue Jan 26 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27556858"> <div itemprop="name">Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Si C,Zhang R,Wu T,Lu G,Hu Y,Zhang H,Xu F,Wei P,Chen K,Tang H,Yeretssian G,Xiong H</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate that DC-derived nitric oxide restrains effector DC development to treat autoimmune and inflammatory diseases.</div> <div itemprodp="datePublished">Tue Nov 15 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27057462"> <div itemprop="name">Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Lee SE,Hong SH,Verma V,Lee YS,Duong TN,Jeong K,Uthaman S,Sung YC,Lee JT,Park IK,Min JJ,Rhee JH</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27239035"> <div itemprop="name">A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Choi IY,Piccio L,Childress P,Bollman B,Ghosh A,Brandhorst S,Suarez J,Michalsen A,Cross AH,Morgan TE,Wei M,Paul F,Bock M,Longo VD</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 07 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27869129"> <div itemprop="name">Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.</div> <div itemprodp="datePublished">Mon Nov 21 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27101989"> <div itemprop="name">Antigen presenting cell abnormalities in the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis.</div> </a> <div itemprop="about">Biochimica et biophysica acta</div> <div itemprop="author">Hersrud SL,Kovács AD,Pearce DA</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that CLN3 deficiency alters antigen presenting cells, which can contribute to the autoimmune response in juvenile neuronal ceroid lipofuscinosis.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27117406"> <div itemprop="name">TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Schleicher U,Paduch K,Debus A,Obermeyer S,König T,Kling JC,Ribechini E,Dudziak D,Mougiakakos D,Murray PJ,Ostuni R,Körner H,Bogdan C</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 03 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27577735"> <div itemprop="name">Multicomponent LBSap vaccine displays immunological and parasitological profiles similar to those of Leish-Tec® and Leishmune® vaccines against visceral leishmaniasis.</div> </a> <div itemprop="about">Parasites & vectors</div> <div itemprop="author">de Mendonça LZ,Resende LA,Lanna MF,Aguiar-Soares RD,Roatt BM,Castro RA,Batista MA,Silveira-Lemos D,Gomes Jde A,Fujiwara RT,Rezende SA,Martins-Filho OA,Corrêa-Oliveira R,Dutra WO,Reis AB,Giunchetti RC</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to compare the effects of the multicomponent LBSap vaccine with those of Leish-Tec® and Leishmune®.</div> <div itemprodp="datePublished">Tue Aug 30 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27906184"> <div itemprop="name">1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Wei C,Mei J,Tang L,Liu Y,Li D,Li M,Zhu X</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the high percentage of peritoneal Treg in endometriosis patients, showing that 1-Methyl-tryptophan attenuates Treg differentiation due to the inhibition of estrogen-IDO1-MRC2 axis.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27119555"> <div itemprop="name">Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Qualai J,Li LX,Cantero J,Tarrats A,Fernández MA,Sumoy L,Rodolosse A,McSorley SJ,Genescà M</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to find markers associated with non-conventional T cell subsets, including γδ T cells and invariant natural killer T cells.</div> <div itemprodp="datePublished">Thu Mar 16 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27302484"> <div itemprop="name">Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25363763"> <div itemprop="name">CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Huang YH,Zhu C,Kondo Y,Anderson AC,Gandhi A,Russell A,Dougan SK,Petersen BS,Melum E,Pertel T,Clayton KL,Raab M,Chen Q,Beauchemin N,Yazaki PJ,Pyzik M,Ostrowski MA,Glickman JN,Rudd CE,Ploegh HL,Franke A,Petsko GA,Kuchroo VK,Blumberg RS</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jan 15 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25485616"> <div itemprop="name">Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.</div> </a> <div itemprop="about">Nature biotechnology</div> <div itemprop="author">Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25848866"> <div itemprop="name">Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Kim MS,Yan J,Wu W,Zhang G,Zhang Y,Cai D</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the role of the brain in innate immunological signals, showing rapid linkage of innate signals and adaptive immunity by the brain-fat axis.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25450716"> <div itemprop="name">Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury.</div> </a> <div itemprop="about">Journal of hepatology</div> <div itemprop="author">Liu Y,Ji H,Zhang Y,Shen X,Gao F,He X,Li GA,Busuttil RW,Kuchroo VK,Kupiec-Weglinski JW</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate whether negative T cell-dependent TIM-3 co-stimulation rescues orthotopic liver transplants stressed by ischaemia-reperfusion from innate immunity-driven inflammation.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26012568"> <div itemprop="name">Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Yi W,Hu X,Chen Z,Liu L,Tian Y,Chen H,Cong YS,Yang F,Zhang L,Rudolph KL,Zhang Z,Zhao Y,Ju Z</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jul 30 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26621452"> <div itemprop="name">IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Pallangyo CK,Ziegler PK,Greten FR</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Dec 14 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26601269"> <div itemprop="name">Cis-regulatory mechanisms governing stem and progenitor cell transitions.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to illustrate a paradigm in which cis-elements in a locus differentially control stem and progenitor cell transitions.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26321127"> <div itemprop="name">Adaptive Immune Regulation of Mammary Postnatal Organogenesis.</div> </a> <div itemprop="about">Developmental cell</div> <div itemprop="author">Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence</div> <div itemprodp="datePublished">Mon Sep 14 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26321127"> <div itemprop="name">Adaptive Immune Regulation of Mammary Postnatal Organogenesis.</div> </a> <div itemprop="about">Developmental cell</div> <div itemprop="author">Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence</div> <div itemprodp="datePublished">Mon Sep 14 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26120731"> <div itemprop="name">B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.</div> </a> <div itemprop="about">Autophagy</div> <div itemprop="author">Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Mon Apr 18 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26305941"> <div itemprop="name">IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Sosa RA,Murphey C,Robinson RR,Forsthuber TG</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence</div> <div itemprodp="datePublished">Tue Sep 08 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25613378"> <div itemprop="name">Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25869671"> <div itemprop="name">TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.</div> </a> <div itemprop="about">The Journal of cell biology</div> <div itemprop="author">Na BR,Kim HR,Piragyte I,Oh HM,Kwon MS,Akber U,Lee HS,Park DS,Song WK,Park ZY,Im SH,Rho MC,Hyun YM,Kim M,Jun CD</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to reveal a novel function of TAGLN2 in enhancing T cell responses.</div> <div itemprodp="datePublished">Mon Apr 13 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25808315"> <div itemprop="name">Activated NKT cells imprint NK-cell differentiation, functionality and education.</div> </a> <div itemprop="about">European journal of immunology</div> <div itemprop="author">Riese P,Trittel S,May T,Cicin-Sain L,Chambers BJ,Guzmán CA</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the cellular cross-talk between natural killer T cells and natural killer cells.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25403570"> <div itemprop="name">Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.</div> </a> <div itemprop="about">Immunology and cell biology</div> <div itemprop="author">Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25888642"> <div itemprop="name">IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Otero DC,Fares-Frederickson NJ,Xiao M,Baker DP,David M</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the mechanism by which interferon beta limits T cell responses and its potential therapeutic use for multiple sclerosis.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25740947"> <div itemprop="name">B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Pone EJ,Lam T,Lou Z,Wang R,Chen Y,Liu D,Edinger AL,Xu Z,Casali P</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26538392"> <div itemprop="name">MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Singh Y,Garden OA,Lang F,Cobb BS</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to understand miRNA function in Treg development..</div> <div itemprodp="datePublished">Tue Dec 15 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26075017"> <div itemprop="name">Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced eosinophilic airway inflammation in asthma.</div> </a> <div itemprop="about">Chinese medicine</div> <div itemprop="author">Zhang HP,Fu JJ,Fan T,Zhang WB,Wang ZL,Wang L,Wang G</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26693207"> <div itemprop="name">Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis.</div> </a> <div itemprop="about">Mediators of inflammation</div> <div itemprop="author">Hou YC,Wu JM,Wang MY,Wu MH,Chen KY,Yeh SL,Lin MT</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate that appropriate dosage of APS reduces Treg populations and elicits a more balanced Th1/Th2 response to attenuate sepsis-induced immunosuppression.</div> <div itemprodp="datePublished">Tue Sep 20 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24818989"> <div itemprop="name">Control of the Survival and Growth of Human Glioblastoma Grafted Into the Spinal Cord of Mice by Taking Advantage of Immunorejection.</div> </a> <div itemprop="about">Cell transplantation</div> <div itemprop="author">Itakura G,Kobayashi Y,Nishimura S,Iwai H,Takano M,Iwanami A,Toyama Y,Okano H,Nakamura M</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to establish a glioblastoma multiforme xenograft model mouse.</div> <div itemprodp="datePublished">Mon Apr 11 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25916989"> <div itemprop="name">Distinct Contributions of CD4+ and CD8+ T Cells to Pathogenesis of Trypanosoma brucei Infection in the Context of Gamma Interferon and Interleukin-10.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Liu G,Sun D,Wu H,Zhang M,Huan H,Xu J,Zhang X,Zhou H,Shi M</div> <div itemprop="description">11-0041 was used in Immunocytochemistry to study the distinct roles of CD4 and CD8 T cells in the context of IFN-γ and IL-10 during Trypanosoma brucei infections.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25916989"> <div itemprop="name">Distinct Contributions of CD4+ and CD8+ T Cells to Pathogenesis of Trypanosoma brucei Infection in the Context of Gamma Interferon and Interleukin-10.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Liu G,Sun D,Wu H,Zhang M,Huan H,Xu J,Zhang X,Zhou H,Shi M</div> <div itemprop="description">11-0041 was used in Immunocytochemistry to study the distinct roles of CD4 and CD8 T cells in the context of IFN-γ and IL-10 during Trypanosoma brucei infections.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26491697"> <div itemprop="name">Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.</div> </a> <div itemprop="about">BioMed research international</div> <div itemprop="author">Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to suggest that the recently described nuclear variant of BMP2 is necessary for efficient secondary immune responses.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26265369"> <div itemprop="name">Injectable cryogel-based whole-cell cancer vaccines.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Bencherif SA,Warren Sands R,Ali OA,Li WA,Lewin SA,Braschler TM,Shih TY,Verbeke CS,Bhatta D,Dranoff G,Mooney DJ</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate cancer vaccines based on injectable whole-cell cryogels.</div> <div itemprodp="datePublished">Wed Aug 12 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25973010"> <div itemprop="name">BTLA associates with increased Foxp3 expression in CD4(+) T cells in dextran sulfate sodium-induced colitis.</div> </a> <div itemprop="about">International journal of clinical and experimental pathology</div> <div itemprop="author">Zhang HX,Zhu B,Fu XX,Zeng JC,Zhang JA,Wang WD,Kong B,Xiang WY,Zhong J,Wang CY,Zheng XB,Xu JF</div> <div itemprop="description">11-0041 was used in Immunofluorescence to determine that BTLA may be involved in the control of inflammatory responses through increasing Foxp3 expression in DSS-induced colitis.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25973010"> <div itemprop="name">BTLA associates with increased Foxp3 expression in CD4(+) T cells in dextran sulfate sodium-induced colitis.</div> </a> <div itemprop="about">International journal of clinical and experimental pathology</div> <div itemprop="author">Zhang HX,Zhu B,Fu XX,Zeng JC,Zhang JA,Wang WD,Kong B,Xiang WY,Zhong J,Wang CY,Zheng XB,Xu JF</div> <div itemprop="description">11-0041 was used in Immunofluorescence to determine that BTLA may be involved in the control of inflammatory responses through increasing Foxp3 expression in DSS-induced colitis.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26626303"> <div itemprop="name">CD11c(hi) Dendritic Cells Regulate Ly-6C(hi) Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Kim JH,Choi JY,Kim SB,Uyangaa E,Patil AM,Han YW,Park SY,Lee JH,Kim K,Eo SK</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to define the contribution of DCs to T cell-independent innate defence in immune-privileged CNS upon infection with neurotropic viruses.</div> <div itemprodp="datePublished">Wed Dec 02 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25931125"> <div itemprop="name">Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Pamir N,Liu NC,Irwin A,Becker L,Peng Y,Ronsein GE,Bornfeldt KE,Duffield JS,Heinecke JW</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate dendritic cells and show cells that are dependent on GM-CSF restrain lean adipose tissue expansion.</div> <div itemprodp="datePublished">Fri Jun 05 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26392000"> <div itemprop="name">Role of T-cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ofotokun I,Titanji K,Vikulina T,Roser-Page S,Yamaguchi M,Zayzafoon M,Williams IR,Weitzmann MN</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to suggest T-cell repopulation and/or immune reconstitution as putative mechanisms for bone loss following ART initiation.</div> <div itemprodp="datePublished">Tue Sep 22 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26085010"> <div itemprop="name">Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Wang Y,Zhang J,Wu Y,Ding ZY,Luo XM,Liu J,Zhong WN,Deng GH,Xia XY,Deng YT,Wei YQ,Jiang Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 18 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24380384"> <div itemprop="name">Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.</div> </a> <div itemprop="about">Cell transplantation</div> <div itemprop="author">Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Nov 16 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24380384"> <div itemprop="name">Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.</div> </a> <div itemprop="about">Cell transplantation</div> <div itemprop="author">Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Nov 16 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26370586"> <div itemprop="name">Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Guo A,He D,Xu HB,Geng CA,Zhao J</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study how the promotion of regulatory T cell induction could be an underlying mechanism of the herbal medicine licorice.</div> <div itemprodp="datePublished">Tue Sep 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26418311"> <div itemprop="name">Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Deng YQ,Yang YQ,Wang SB,Li F,Liu MZ,Hua QQ,Tao ZZ</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 31 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25673304"> <div itemprop="name">H9N2 influenza whole inactivated virus combined with polyethyleneimine strongly enhances mucosal and systemic immunity after intranasal immunization in mice.</div> </a> <div itemprop="about">Clinical and vaccine immunology : CVI</div> <div itemprop="author">Qin T,Yin Y,Huang L,Yu Q,Yang Q</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the immune activity of polyethyleneimine with H9N2 influenza whole inactivated virus, showing that it enhances mucosal and systemic immunity after intranasal immunization.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26372309"> <div itemprop="name">dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26372309"> <div itemprop="name">dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26372309"> <div itemprop="name">dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25706286"> <div itemprop="name">Controlling immune rejection is a fail-safe system against potential tumorigenicity after human iPSC-derived neural stem cell transplantation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Itakura G,Kobayashi Y,Nishimura S,Iwai H,Takano M,Iwanami A,Toyama Y,Okano H,Nakamura M</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to determine the feasibility of ablation of the tumors formed after hiPSC-NS/PC transplantation through immunoregulation.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26137245"> <div itemprop="name">Effects of Feijining Decoction on vascular endothelial growth factor protein expression and changes of T cell subsets in Lewis lung carcinoma-bearing mice.</div> </a> <div itemprop="about">Biomedical reports</div> <div itemprop="author">Zhou L,Pan Y,Xing Y,Gao H,Xie X,Yin D</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of Feijining Decoction (FJND) on VEGF protein expression and T-cell subsets in Lewis lung cancer bearing mice, showing that mice treated with FJND had significantly reduced VEGF and increased splenic CD4(+) and CD4(+)/CD8(+), suggesting that FJND can inhibit tumour growth.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26321145"> <div itemprop="name">Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 08 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26770347"> <div itemprop="name">DC targeting DNA vaccines induce protective and therapeutic antitumor immunity in mice.</div> </a> <div itemprop="about">International journal of clinical and experimental medicine</div> <div itemprop="author">Wang Q,Cao W,Yang ZG,Zhao GF</div> <div itemprop="description">11-0041 was used in Magnetic cell separation to show that DNA vaccine which targeting of dendritic cells in situ by the means of antibody-antigen conjugates may be a novel way to induce long-lasting antitumor immunity.</div> <div itemprodp="datePublished">Fri Jan 15 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25267791"> <div itemprop="name">Immunoglobulin E plays an immunoregulatory role in lupus.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Dema B,Charles N,Pellefigues C,Ricks TK,Suzuki R,Jiang C,Scheffel J,Hasni S,Hoffman V,Jablonski M,Sacré K,Gobert D,Papo T,Daugas E,Crampton S,Bolland S,Rivera J</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to explore the effect of IgE deficiency on the inflammatory response in FcγRIIB-deficient mice, which hastens and results in a more aggressive lupuslike disease.</div> <div itemprodp="datePublished">Mon Oct 20 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24905997"> <div itemprop="name">Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.</div> </a> <div itemprop="about">Autophagy</div> <div itemprop="author">Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24129164"> <div itemprop="name">CX3CR1⁺ cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Rossini V,Zhurina D,Radulovic K,Manta C,Walther P,Riedel CU,Niess JH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study immune cell communication during the development of transfer colitis.</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24453977"> <div itemprop="name">Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Ataide MA,Andrade WA,Zamboni DS,Wang D,Souza Mdo C,Franklin BS,Elian S,Martins FS,Pereira D,Reed G,Fitzgerald KA,Golenbock DT,Gazzinelli RT</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24869907"> <div itemprop="name">Low-dose 5-aza-2'-deoxycytidine pretreatment inhibits experimental autoimmune encephalomyelitis by induction of regulatory T cells.</div> </a> <div itemprop="about">Molecular medicine (Cambridge, Mass.)</div> <div itemprop="author">Chan MW,Chang CB,Tung CH,Sun J,Suen JL,Wu SF</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate whether loss of P53 function contributes to persistent activation of STAT3 and modification of the pancreatic tumor stroma.</div> <div itemprodp="datePublished">Thu Jun 26 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23939973"> <div itemprop="name">Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Povinelli BJ,Nemeth MJ</div> <div itemprop="description">11-0041 was used in Immunocytochemistry to study whether Ryk protein regulates the response of haematopoietic stem cells to Wnt5a.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24296878"> <div itemprop="name">Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model.</div> </a> <div itemprop="about">Laboratory investigation; a journal of technical methods and pathology</div> <div itemprop="author">Zhao W,Zhang L,Xu Y,Zhang Z,Ren G,Tang K,Kuang P,Zhao B,Yin Z,Wang X</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the complex tumor-host interactions in hepatocellular carcinoma, specifically how the immunosuppressive properties of hepatic stellate cells may contribute to hepatocellular carcinoma occurrence and development..</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25135828"> <div itemprop="name">CD1d(hi)CD5+ B cells expanded by GM-CSF in vivo suppress experimental autoimmune myasthenia gravis.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Sheng JR,Quan S,Soliven B</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the tolorogenic effects of B10 cells in Experimental Autoimmune Myasthenia Gravis.</div> <div itemprodp="datePublished">Mon Sep 15 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24634494"> <div itemprop="name">Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Steinbach EC,Kobayashi T,Russo SM,Sheikh SZ,Gipson GR,Kennedy ST,Uno JK,Mishima Y,Borst LB,Liu B,Herfarth H,Ting JP,Sartor RB,Plevy SE</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to explore the role of IL-10 and IL-12/23 in the development of microbiota-dependent colitis.</div> <div itemprodp="datePublished">Tue Apr 15 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24453248"> <div itemprop="name">Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Mercadante AC,Perobelli SM,Alves AP,Gonçalves-Silva T,Mello W,Gomes-Santos AC,Miyoshi A,Azevedo V,Faria AM,Bonomo A</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to suggest that combined therapy is a promising strategy for prevention of GVHD with preservation of graft-versus-leukemia in allogenic HSCT.</div> <div itemprodp="datePublished">Sat Feb 15 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24935925"> <div itemprop="name">Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">El-Zaatari M,Chang YM,Zhang M,Franz M,Shreiner A,McDermott AJ,van der Sluijs KF,Lutter R,Grasberger H,Kamada N,Young VB,Huffnagle GB,Kao JY</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show tryptophan catabolism restricts IGN-gamma expressing neutrophils and Clostridium difficile immunopathology.</div> <div itemprodp="datePublished">Tue Jul 15 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24325348"> <div itemprop="name">Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Mar 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25374756"> <div itemprop="name">The Serine Protease Inhibitor, 4-(2-aminoethyl) Benzene Sulfonyl Fluoride Hydrochloride, Reduces Allergic Inflammation in a House Dust Mite Allergic Rhinitis Mouse Model.</div> </a> <div itemprop="about">Allergy, asthma & immunology research</div> <div itemprop="author">Kim BY,Park HR,Shin JH,Kim SW,Cho JH,Park YJ,Kim SW</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the applications of the serine protease inhibitor 4-(2-aminoethyl) benzene sulfonyl fluoride hydrochloride in a mouse model of allergic rhinitis.</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24363069"> <div itemprop="name">Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells.</div> </a> <div itemprop="about">Carcinogenesis</div> <div itemprop="author">Ravindran A,Mohammed J,Gunderson AJ,Cui X,Glick AB</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study how TGFβ1 signalling has a tumour-promoting role in UVB-induced skin carcinogenesis, which is mediated in part through its role in UVB-induced migration of dDC and cutaneous inflammation.</div> <div itemprodp="datePublished">Tue Apr 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25553252"> <div itemprop="name">Increased Th17 cells in flow cytometer-sorted CD45RO-positive memory CD4 T cells from patients with systemic lupus erythematosus.</div> </a> <div itemprop="about">Lupus science & medicine</div> <div itemprop="author">Liu MF,Wang CR</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that increased frequencies of Th17 cells positively correlate with disease activity and proteinuria in SLE patients, confirming the dysregulation of Th17/IL-17 in SLE.</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25525304"> <div itemprop="name">Immunomodulatory effects of polysaccharide from marine fungus Phoma herbarum YS4108 on T cells and dendritic cells.</div> </a> <div itemprop="about">Mediators of inflammation</div> <div itemprop="author">Chen S,Ding R,Zhou Y,Zhang X,Zhu R,Gao XD</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the immunomodulatory effects of polysaccharide from a marine fungus Phoma herbarum on T cells and dendritic cells.</div> <div itemprodp="datePublished">Tue Sep 08 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24253609"> <div itemprop="name">Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.</div> </a> <div itemprop="about">Human vaccines & immunotherapeutics</div> <div itemprop="author">Wang S,Wu B,Xue J,Wang M,Chen R,Wang B</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jan 05 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24326266"> <div itemprop="name">Enhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in mice.</div> </a> <div itemprop="about">Human vaccines & immunotherapeutics</div> <div itemprop="author">Xiao L,Wang D,Sun C,Li P,Jin Y,Feng L,Chen L</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study whether co-administration of sPD-1 and sTim-3 with an adenovirus vectored SIV vaccine (rAd5-SIV) can enhance cell mediated immune responses.</div> <div itemprodp="datePublished">Mon Mar 30 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24359574"> <div itemprop="name">High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.</div> </a> <div itemprop="about">Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research</div> <div itemprop="author">Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24798997"> <div itemprop="name">Somatostatin inhibits the production of interferon-γ by intestinal epithelial cells during intestinal ischemia-reperfusion in macaques.</div> </a> <div itemprop="about">Digestive diseases and sciences</div> <div itemprop="author">Liu L,Tan Q,Hu B,Wu H,Wang C,Tang C</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Oct 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24308870"> <div itemprop="name">Immune selection of tumor cells in TCR β-chain transgenic mice.</div> </a> <div itemprop="about">Journal of immunotoxicology</div> <div itemprop="author">Silaeva YY,Grinenko TS,Vagida MS,Kalinina AA,Khromykh LM,Kazansky DB</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to compare the ability of WT and transgenic, immune-compromised mice to reject EL4 thymoma cells.</div> <div itemprodp="datePublished">Wed Oct 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24475975"> <div itemprop="name">Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.</div> </a> <div itemprop="about">BMC cancer</div> <div itemprop="author">Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jan 29 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24475975"> <div itemprop="name">Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.</div> </a> <div itemprop="about">BMC cancer</div> <div itemprop="author">Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jan 29 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25490199"> <div itemprop="name">A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 28 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25385531"> <div itemprop="name">Autophagy is a critical regulator of memory CD8(+) T cell formation.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.</div> <div itemprodp="datePublished">Tue Nov 11 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24886643"> <div itemprop="name">Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.</div> </a> <div itemprop="about">BMC biology</div> <div itemprop="author">Reynolds C,Chong D,Raynsford E,Quigley K,Kelly D,Llewellyn-Hughes J,Altmann D,Boyton R</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study how the conformation of TCR alpha chain CDR3 favours different CD4 cytokine profiles.</div> <div itemprodp="datePublished">Fri May 09 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25315774"> <div itemprop="name">Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Bhattacharya D,Dwivedi VP,Kumar S,Reddy MC,Van Kaer L,Moodley P,Das G</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the inhibition of Th2 cells and Tregs and the subsequent enhancement of the BCG vaccine efficacy.</div> <div itemprodp="datePublished">Fri Nov 28 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24736726"> <div itemprop="name">ASK1 promotes the contact hypersensitivity response through IL-17 production.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Mizukami J,Sato T,Camps M,Ji H,Rueckle T,Swinnen D,Tsuboi R,Takeda K,Ichijo H</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the role of ASK1 in the contact hypersensitivity response.</div> <div itemprodp="datePublished">Wed Apr 16 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25207963"> <div itemprop="name">Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Carty SA,Koretzky GA,Jordan MS</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the signaling pathways required for IL-4 induction of Eomes and CD8(+) innate-like lymphocyte markers in murine CD8SP thymocytes and peripheral CD8(+) T cells.</div> <div itemprodp="datePublished">Thu May 21 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24711459"> <div itemprop="name">Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Bhattacharya D,Dwivedi VP,Maiga M,Maiga M,Van Kaer L,Bishai WR,Das G</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate small molecule-directed immunotherapy against Th2 and regulatory T cell subsets to reduce recurrent Mycobacterium tuberculosis infection and drug resistance.</div> <div itemprodp="datePublished">Fri Jun 06 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24416451"> <div itemprop="name">Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Khattar M,Miyahara Y,Schroder PM,Xie A,Chen W,Stepkowski SM</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the role of IL-2 during early events of T cell activation, showing that IL-21 is a critical regulator of T cell survival during priming under IL-2 deprivation.</div> <div itemprodp="datePublished">Mon Sep 08 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24884568"> <div itemprop="name">An orally active immune adjuvant prepared from cones of Pinus sylvestris, enhances the proliferative phase of a primary T cell response.</div> </a> <div itemprop="about">BMC complementary and alternative medicine</div> <div itemprop="author">Bradley WG,Holm KN,Tanaka A</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the mechanism by which polyphenylpropanoid polysaccharide complex enhances the proliferative phase of a primary T cell response.</div> <div itemprodp="datePublished">Thu May 22 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25202011"> <div itemprop="name">Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Tousif S,Singh DK,Ahmad S,Moodley P,Bhattacharyya M,Van Kaer L,Das G</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that Isoniazid treatment of Mycobacterium tuberculosis treatment is associated with immune impairment.</div> <div itemprodp="datePublished">Fri Oct 31 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25941590"> <div itemprop="name">Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Devaud C,Westwood JA,Teng MW,John LB,Yong CS,Duong CP,Smyth MJ,Darcy PK,Kershaw MH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to provide insights into the immunosuppressive nature of the immune response generated in the kidney microenvironment.</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23852275"> <div itemprop="name">Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Pierson W,Cauwe B,Policheni A,Schlenner SM,Franckaert D,Berges J,Humblet-Baron S,Schönefeldt S,Herold MJ,Hildeman D,Strasser A,Bouillet P,Lu LF,Matthys P,Freitas AA,Luther RJ,Weaver CT,Dooley J,Gray DH,Liston A</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the regulation of the Foxp3+ T cell pool by proliferation and apoptosis, and specifically the role of antiapoptoic Mcl-1 in T cell survival.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24312102"> <div itemprop="name">Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Piras G,Rattazzi L,McDermott A,Deacon R,D'Acquisto F</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to explore a possible correlation between T cell activation and changes in emotional behavior in a multiple sclerosis mouse model.</div> <div itemprodp="datePublished">Fri Dec 06 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22968420"> <div itemprop="name">Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Domingos-Pereira S,Decrausaz L,Derré L,Bobst M,Romero P,Schiller JT,Jichlinski P,Nardelli-Haefliger D</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the immune effects of the instillation of Toll-like receptor agonists after subcutaneous E7 vaccination.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22832490"> <div itemprop="name">TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity.</div> </a> <div itemprop="about">The Journal of investigative dermatology</div> <div itemprop="author">Mohammed J,Gunderson AJ,Khong HH,Koubek RD,Udey MC,Glick AB</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to highlight a role for keratinocyte-derived TGFβ1 in dendritic cell trafficking and in the initiation of skin inflammation.</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23362346"> <div itemprop="name">Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23589339"> <div itemprop="name">Intrinsic T- and B-cell defects impair T-cell-dependent antibody responses in mice lacking the actin-bundling protein L-plastin.</div> </a> <div itemprop="about">European journal of immunology</div> <div itemprop="author">Todd EM,Deady LE,Morley SC</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the role of L-plastin in the modulation of both T- and B-cell immune responses.</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23777580"> <div itemprop="name">Enhanced autoimmunity associated with induction of tumor immunity in thyroiditis-susceptible mice.</div> </a> <div itemprop="about">Thyroid : official journal of the American Thyroid Association</div> <div itemprop="author">Kari S,Flynn JC,Zulfiqar M,Snower DP,Elliott BE,Kong YC</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to indicate that genetic predisposition to autoimmune disease could enhance autoimmunity during induction of tumor immunity in thyroiditis-susceptible mice.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24046360"> <div itemprop="name">A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).</div> </a> <div itemprop="about">Disease models & mechanisms</div> <div itemprop="author">Carofino BL,Ayanga B,Justice MJ</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23941891"> <div itemprop="name">Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.</div> </a> <div itemprop="about">Human vaccines & immunotherapeutics</div> <div itemprop="author">Wu B,Zou Q,Hu Y,Wang B</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23336253"> <div itemprop="name">The crosstalk: Tumor-infiltrating lymphocytes rich in regulatory T cells suppressed cancer-associated fibroblasts.</div> </a> <div itemprop="about">Acta oncologica (Stockholm, Sweden)</div> <div itemprop="author">Fu Z,Zuo Y,Li D,Xu W,Li D,Chen H,Zheng S</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the suppression of CAFs and NFs by Tregs-rich TILs.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24135451"> <div itemprop="name">An increased number of CD4+CD25+ cells induced by an oral administration of Lactobacillus plantarum NRIC0380 are involved in antiallergic activity.</div> </a> <div itemprop="about">International archives of allergy and immunology</div> <div itemprop="author">Yoshida T,Fujiwara W,Enomoto M,Nakayama S,Matsuda H,Sugiyama H,Shimojoh M,Okada S,Hattori M</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study how increased CD4+CD25+ cells are involved in antiallergic activity.</div> <div itemprodp="datePublished">Fri Feb 07 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23691499"> <div itemprop="name">No immunogenicity of IPS cells in syngeneic host studied by in vivo injection and 3D scaffold experiments.</div> </a> <div itemprop="about">BioMed research international</div> <div itemprop="author">Thanasegaran S,Cheng Z,Ito S,Nishio N,Isobe K</div> <div itemprop="description">11-0041 was used in Immunohistochemistry to investigate the change in iPSC density inside a three-dimensional porous scaffold transplanted into sygeneic and allogeneic mice.</div> <div itemprodp="datePublished">Wed Dec 04 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22954711"> <div itemprop="name">The role of IL-2 in the activation and expansion of regulatory T-cells and the development of experimental autoimmune encephalomyelitis.</div> </a> <div itemprop="about">Immunobiology</div> <div itemprop="author">Rouse M,Nagarkatti M,Nagarkatti PS</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the effect of administration of IL-2 on the development of EAE, showing that pre-treatment causes significant amelioration of EAE.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23690682"> <div itemprop="name">Enhanced immune response against HIV-1 induced by a heterologous DNA prime-adenovirus boost vaccination using mannosylated polyethyleneimine as DNA vaccine adjuvant.</div> </a> <div itemprop="about">International journal of nanomedicine</div> <div itemprop="author">Li M,Jiang Y,Xu C,Zhang Z,Sun X</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Apr 02 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24324812"> <div itemprop="name">Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jul 31 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23836896"> <div itemprop="name">Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Steelman AJ,Smith R,Welsh CJ,Li J</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the role of galectin-9 in the pathogenesis of multiple sclerosis.</div> <div itemprodp="datePublished">Fri Aug 16 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23941509"> <div itemprop="name">DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice.</div> </a> <div itemprop="about">BMC immunology</div> <div itemprop="author">Cao J,Jin Y,Li W,Zhang B,He Y,Liu H,Xia N,Wei H,Yan J</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate anti-tumoural efficacy and underlying mechanisms of DC-targeting DNA vaccines in mouse breast cancer models, showing that it induces potent anti-tumour immunity in mice.</div> <div itemprodp="datePublished">Wed Aug 14 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23985377"> <div itemprop="name">Thymic stromal lymphopoietin attenuates the development of atherosclerosis in ApoE-/- mice.</div> </a> <div itemprop="about">Journal of the American Heart Association</div> <div itemprop="author">Yu K,Zhu P,Dong Q,Zhong Y,Zhu Z,Lin Y,Huang Y,Meng K,Ji Q,Yi G,Zhang W,Wu B,Mao Y,Cheng P,Zhao X,Mao X,Zeng Q</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to examine the phenotype of TSLP-conditioned bone marrow dendritic cells of apolipoprotein E-deficient mice and their capacity to induce the differentiation of Tregs.</div> <div itemprodp="datePublished">Wed Aug 28 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24260551"> <div itemprop="name">Roscovitine suppresses CD4+ T cells and T cell-mediated experimental uveitis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Zhang Z,Liu Q,Leskov KS,Wu X,Duan J,Zhang GL,Hall M,Rosenbaum JT</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to test the immunosuppressive effect of roscovitine, a potent CdK2 inhibitor, on CD4+ T cell activation, proliferation, and function.</div> <div itemprodp="datePublished">Mon Jun 30 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23838891"> <div itemprop="name">CD4⁺ but not CD8⁺ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice.</div> </a> <div itemprop="about">Translational psychiatry</div> <div itemprop="author">Rattazzi L,Piras G,Ono M,Deacon R,Pariante CM,D'Acquisto F</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to understand the mechanisms linking an immunocompromised state to a variety of mood disorders.</div> <div itemprodp="datePublished">Tue Jul 09 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23527234"> <div itemprop="name">Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Duan X,Imai T,Chou B,Tu L,Himeno K,Suzue K,Hirai M,Taniguchi T,Okada H,Shimokawa C,Hisaeda H</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study how RBCs of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites.</div> <div itemprodp="datePublished">Tue Sep 17 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23409194"> <div itemprop="name">Partial depletion of regulatory T cells does not influence the inflammation caused by high dose hemi-body irradiation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Ma S,Richardson JA,Bitmansour A,Solberg TD,Pidikiti R,Song K,Stojadinovic S,Vitetta ES,Meyer JJ</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of partial depletion of regulatory T cells alongside ionizing radiation on inflammation and tissue injury in mice.</div> <div itemprodp="datePublished">Mon Jul 29 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24069337"> <div itemprop="name">Lack of endogenous IL-10 enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Corsetti PP,de Almeida LA,Carvalho NB,Azevedo V,Silva TM,Teixeira HC,Faria AC,Oliveira SC</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to evaluate the contribution of IL-10 in host immune response and pathology during B. abortus infection.</div> <div itemprodp="datePublished">Sun Jun 15 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23776480"> <div itemprop="name">The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show CD69 is a negative regulator of inflammatory responses in the intestine, reducing the accumulation of CD4 T cells in cLP during colitis.</div> <div itemprodp="datePublished">Thu Jan 23 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23776480"> <div itemprop="name">The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show CD69 is a negative regulator of inflammatory responses in the intestine, reducing the accumulation of CD4 T cells in cLP during colitis.</div> <div itemprodp="datePublished">Thu Jan 23 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23894468"> <div itemprop="name">Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Schroder PM,Khattar M,Deng R,Xie A,Chen W,Stepkowski SM</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the effect of transient anti-TCRB and anti-LFA1 mAb combination therapy on T cell responses and prolonged allograft survival in mice.</div> <div itemprodp="datePublished">Thu Feb 20 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23646169"> <div itemprop="name">Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infection.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Silva-Filho JL,Souza MC,Ferreira-Dasilva CT,Silva LS,Costa MF,Padua TA,Henriques Md,Morrot A,Savino W,Caruso-Neves C,Pinheiro AA</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to provide evidence for the potential role of Ang II in regulating the splenic immune response.</div> <div itemprodp="datePublished">Tue Nov 26 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22267218"> <div itemprop="name">Transcription factor RORα is critical for nuocyte development.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.</div> <div itemprodp="datePublished">Sun Jan 22 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22422820"> <div itemprop="name">Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to reveal the specificity of E2F8 in mediating Rb function in erythropoiesis.</div> <div itemprodp="datePublished">Thu May 10 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22996659"> <div itemprop="name">Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to identify a novel mutation in a GATA2 cis-element which causes deficits in haematopoietic stem/progenitor activity.</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21765465"> <div itemprop="name">Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Darlington Y,Nguyen TA,Moon SH,Herron A,Rao P,Zhu C,Lu X,Donehower LA</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22427677"> <div itemprop="name">Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.</div> </a> <div itemprop="about">The Journal of infectious diseases</div> <div itemprop="author">Angin M,Kwon DS,Streeck H,Wen F,King M,Rezai A,Law K,Hongo TC,Pyo A,Piechocka-Trocha A,Toth I,Pereyra F,Ghebremichael M,Rodig SJ,Milner DA,Richter JM,Altfeld M,Kaufmann DE,Walker BD,Addo MM</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the frequency and function of Tregs in HIV-1-infected individuals.</div> <div itemprodp="datePublished">Tue May 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22250092"> <div itemprop="name">CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Radulovic K,Manta C,Rossini V,Holzmann K,Kestler HA,Wegenka UM,Nakayama T,Niess JH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate that CD69 knockout can modulate mucosal CD4 T cells and increase colitis levels in a mouse transfer model of the disease.</div> <div itemprodp="datePublished">Wed Feb 15 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23105136"> <div itemprop="name">Arsenic trioxide exerts antitumor activity through regulatory T cell depletion mediated by oxidative stress in a murine model of colon cancer.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Thomas-Schoemann A,Batteux F,Mongaret C,Nicco C,Chéreau C,Annereau M,Dauphin A,Goldwasser F,Weill B,Lemare F,Alexandre J</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to examine the potential for As(2)O(3) to enhance adoptive immunotherapy strategies in human cancer.</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23129756"> <div itemprop="name">Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Richmond JM,Lee J,Green DS,Kornfeld H,Cruikshank WW</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to examine the ability of ManLAM to desensitize T cells to other chemoattractants during mycobacterial infection.</div> <div itemprodp="datePublished">Sat Dec 15 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22815285"> <div itemprop="name">A critical role for Rictor in T lymphopoiesis.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Tang F,Wu Q,Ikenoue T,Guan KL,Liu Y,Zheng P</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the signalling pathway required for T lymphopoiesis, showing a critical role for Rictor.</div> <div itemprodp="datePublished">Wed Aug 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22769242"> <div itemprop="name">Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells.</div> </a> <div itemprop="about">ACS chemical biology</div> <div itemprop="author">Solt LA,Kumar N,He Y,Kamenecka TM,Griffin PR,Burris TP</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to evaluate the specificity of a synthetic compound for RORγ and its effects on Th17 and Treg cell development.</div> <div itemprodp="datePublished">Fri Sep 21 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23023071"> <div itemprop="name">In vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritis.</div> </a> <div itemprop="about">Cellular immunology</div> <div itemprop="author">Kobezda T,Ghassemi-Nejad S,Glant TT,Mikecz K</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to examine whether lymph node T cells reduce their motility upon contact with relevant antigen-presenting cells in WT mice.</div> <div itemprodp="datePublished">Mon Jan 07 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22025508"> <div itemprop="name">MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Goodyear A,Troyer R,Bielefeldt-Ohmann H,Dow S</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to find that MyD88-/- mice were highly susceptible to pulmonary challenge with B. mallei and had significantly short survival times, increased bacterial burdens, and severe organ pathology compared to wild-type mice.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22969934"> <div itemprop="name">Resveratrol analogue HS-1793 induces the modulation of tumor-derived T cells.</div> </a> <div itemprop="about">Experimental and therapeutic medicine</div> <div itemprop="author">Choi YJ,Yang KM,Kim SD,Yoo YH,Lee SW,Seo SY,Suh H,Yee ST,Jeong MH,Jo WS</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to reveal the suppressive effect HS-1793 has on Treg cells, and its likely contribution to tumor-specific cytotoxic T lymphocyte responses.</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22586481"> <div itemprop="name">Interleukin-7 influences FOXP3+CD4+ regulatory T cells peripheral homeostasis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Simonetta F,Gestermann N,Martinet KZ,Boniotto M,Tissières P,Seddon B,Bourgeois C</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to elucidate the mechanisms governing Treg cell survival and homeostasis.</div> <div itemprodp="datePublished">Wed Sep 26 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23077616"> <div itemprop="name">Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jul 19 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22879894"> <div itemprop="name">Granulocytes and vascularization regulate uterine bleeding and tissue remodeling in a mouse menstruation model.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Menning A,Walter A,Rudolph M,Gashaw I,Fritzemeier KH,Roese L</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate mechanisms underlying pathogenesis of menstrual disorders, showing that granulocytes and vascularisation regulate uterine bleeding and tissue remodelling.</div> <div itemprodp="datePublished">Thu Jan 10 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23056267"> <div itemprop="name">Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Xiong A,Duan L,Chen J,Fan Z,Zheng F,Tan Z,Gong F,Fang M</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the role of Flt3 and Flt3L in immune tolerance, showing that Flt3L combined with rapamycin promotes cardiac allograft tolerance via dendritic cell induction.</div> <div itemprodp="datePublished">Tue Jun 11 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23091595"> <div itemprop="name">MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Yao R,Ma YL,Liang W,Li HH,Ma ZJ,Yu X,Liao YH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the role of miR-155 in the mechanisms involved in CD4(+) CD25(+) regulatory T (Treg)/T helper (Th)17 cell differentiation and function.</div> <div itemprodp="datePublished">Thu Mar 28 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21419662"> <div itemprop="name">RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.</div> <div itemprodp="datePublished">Fri Mar 25 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21607286"> <div itemprop="name">Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle.</div> </a> <div itemprop="about">Molecular medicine (Cambridge, Mass.)</div> <div itemprop="author">Eghtesad S,Jhunjhunwala S,Little SR,Clemens PR</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Sun Mar 25 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20479776"> <div itemprop="name">Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells.</div> </a> <div itemprop="about">Immunology and cell biology</div> <div itemprop="author">Finley SD,Gupta D,Cheng N,Klinke DJ</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to infer the relative importance of regulatory mechanisms that modulate the activation of STAT4 in naive CD4(+) T cells.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22039299"> <div itemprop="name">T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22079986"> <div itemprop="name">Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Kondilis-Mangum HD,Shih HY,Mahowald G,Sleckman BP,Krangel MS</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to analyse the contributions of chromatin accessibility and locus conformation to feedback inhibition.</div> <div itemprodp="datePublished">Thu Dec 15 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22075702"> <div itemprop="name">Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the regulation of murine dendritic cell cytotoxic functions by T lymphocytes.</div> <div itemprodp="datePublished">Thu Dec 15 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21572035"> <div itemprop="name">Genetic variation determines mast cell functions in experimental asthma.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Becker M,Reuter S,Friedrich P,Doener F,Michel A,Bopp T,Klein M,Schmitt E,Schild H,Radsak MP,Echtenacher B,Taube C,Stassen M</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in allergic asthma.</div> <div itemprodp="datePublished">Wed Jun 15 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21896864"> <div itemprop="name">Regulation of experimental autoimmune uveoretinitis by anti-delta-like ligand 4 monoclonal antibody.</div> </a> <div itemprop="about">Investigative ophthalmology & visual science</div> <div itemprop="author">Ishida W,Fukuda K,Sakamoto S,Koyama N,Koyanagi A,Yagita H,Fukushima A</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the involvement of δ-like ligand (Dll)4 in the development of experimental autoimmune uveoretinitis in B10.RIII mice.</div> <div itemprodp="datePublished">Mon Oct 17 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21300776"> <div itemprop="name">Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Carvalho NB,Oliveira FS,Durães FV,de Almeida LA,Flórido M,Prata LO,Caliari MV,Appelberg R,Oliveira SC</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the role of Toll-like receptor 9 (TLR9) in innate immunity to Mycobacterium avium.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21949815"> <div itemprop="name">T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Moro H,Otero DC,Tanabe Y,David M</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate that type I interferons and STAT1 play an important role in the survival of MHC class I-restricted T cells.</div> <div itemprodp="datePublished">Fri Feb 03 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21674029"> <div itemprop="name">Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Pazirandeh A,Sultana T,Mirza M,Rozell B,Hultenby K,Wallis K,Vennström B,Davis B,Arner A,Heuchel R,Löhr M,Philipson L,Sollerbrant K</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate that CAR exerts important functions in the physiology of several organs in vivo in mice.</div> <div itemprodp="datePublished">Fri Sep 30 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20017191"> <div itemprop="name">C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells.</div> </a> <div itemprop="about">European journal of immunology</div> <div itemprop="author">Weaver DJ,Reis ES,Pandey MK,Köhl G,Harris N,Gerard C,Köhl J</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate that C5aR signalling in DCs affects the development of immune cells.</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19950187"> <div itemprop="name">Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome.</div> </a> <div itemprop="about">European journal of immunology</div> <div itemprop="author">Reimer T,Shaw MH,Franchi L,Coban C,Ishii KJ,Akira S,Horii T,Rodriguez A,Núñez G</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the role of Nlrp3 in experimental cerebral malaria.</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20200244"> <div itemprop="name">Measles virus-induced immunosuppression in SLAM knock-in mice.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Koga R,Ohno S,Ikegame S,Yanagi Y</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to generate a model to investigate the mechanism by which the measles virus causes immunosuppression, showing that SLAM knock-in mice lacking the expression of the alpha/beta-interferon receptor could serve as a model.</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20186173"> <div itemprop="name">Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation.</div> </a> <div itemprop="about">Cancer gene therapy</div> <div itemprop="author">Whelan MC,Casey G,MacConmara M,Lederer JA,Soden D,Collins JK,Tangney M,O'Sullivan GC</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the use of a combined immunogene therapy and regulatory T-cell inactivation against weakly immunogenic solid tumours.</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20083670"> <div itemprop="name">The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Sivick KE,Schaller MA,Smith SN,Mobley HL</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show that IL-17A is a key mediator for the innate immune response to UTIs.</div> <div itemprodp="datePublished">Mon Feb 15 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20720211"> <div itemprop="name">CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Kitamura K,Farber JM,Kelsall BL</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to conclude that CCR6 expression on Treg cells was required for the full function of Treg cell-mediated suppression in a model of colitis.</div> <div itemprodp="datePublished">Wed Sep 15 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20181656"> <div itemprop="name">IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice.</div> </a> <div itemprop="about">International immunology</div> <div itemprop="author">Voronov E,Dotan S,Gayvoronsky L,White RM,Cohen I,Krelin Y,Benchetrit F,Elkabets M,Huszar M,El-On J,Apte RN</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to assess the role of host derived IL-1 on the course of Leishmania major infection in susceptible BLAB/c mice.</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20827278"> <div itemprop="name">Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.</div> </a> <div itemprop="about">Gene therapy</div> <div itemprop="author">Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20176793"> <div itemprop="name">CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Eppert BL,Motz GT,Wortham BW,Flury JL,Borchers MT</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the roles of CCR7 in the host defense against pulmonary infection, showing that CCR7 deficiency leads to leukocyte activation and increased infection clearance.</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20422018"> <div itemprop="name">Efficient isolation of mouse liver NKT cells by perfusion.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Fang X,Du P,Liu Y,Tang J</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to develop a simple method to isolate NKT cells using perfusion, with similar yield to the traditional methods.</div> <div itemprodp="datePublished">Wed Apr 21 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20694680"> <div itemprop="name">Flow cytometry analysis of transcription factors in T lymphocytes.</div> </a> <div itemprop="about">Methods in molecular biology (Clifton, N.J.)</div> <div itemprop="author">Albu DI,Califano D,Avram D</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to develop and optimise a protocol for the rapid and convenient detection of the transcription factor BCL11B in T lymphocyte subpopulations.</div> <div itemprodp="datePublished">Tue Dec 28 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20111738"> <div itemprop="name">Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.</div> </a> <div itemprop="about">Journal of biomedicine & biotechnology</div> <div itemprop="author">Xu X,Wen X,Chi Y,He L,Zhou S,Wang X,Zhao J,Liu F,Su C</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to suggest that Th1 or Th2 cell apoptosis is preferentially induced by different schistosome antigens during different stages of infection.</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19497969"> <div itemprop="name">Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.</div> </a> <div itemprop="about">Journal of the American Society of Nephrology : JASN</div> <div itemprop="author">Kinsey GR,Sharma R,Huang L,Li L,Vergis AL,Ye H,Ju ST,Okusa MD</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate whether the anti-inflammatory effects of CD4(+)CD25(+)FoxP3(+) Tregs protect against renal IRI.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19375891"> <div itemprop="name">Naturally-existing CD4(+)CD25(+)Foxp3(+) regulatory T cells are required for tolerance to experimental autoimmune thyroiditis induced by either exogenous or endogenous autoantigen.</div> </a> <div itemprop="about">Journal of autoimmunity</div> <div itemprop="author">Morris GP,Brown NK,Kong YC</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to highlight the important role of Tregs in mediating self-tolerance in relation to experimental autoimmune thyroiditis.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19276342"> <div itemprop="name">The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Ozao-Choy J,Ma G,Kao J,Wang GX,Meseck M,Sung M,Schwartz M,Divino CM,Pan PY,Chen SH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to suggest that sunitinib can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy for advanced malignancies.</div> <div itemprodp="datePublished">Sun Mar 15 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19318568"> <div itemprop="name">Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Du G,Jin L,Han X,Song Z,Zhang H,Liang W</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to determine whether mouse models of idiopathic pulmonary fibrosis have high incidence of lung cancer, showing that Naringenin could treat lung fibrosis and metastasis.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19609979"> <div itemprop="name">Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg.</div> </a> <div itemprop="about">European journal of immunology</div> <div itemprop="author">Shi Z,Okuno Y,Rifa'i M,Endharti AT,Akane K,Isobe K,Suzuki H</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to suggest that human CD8(+)CXCR3(+) T cells are the counterparts of murine CD8(+)CD122(+) Treg.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19386699"> <div itemprop="name">Lymphocyte and antibody responses reduce enterovirus 71 lethality in mice by decreasing tissue viral loads.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Lin YW,Chang KC,Kao CM,Chang SP,Tung YY,Chen SH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the functions of lymphocyte and antibody responses in EV71 infection.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19498460"> <div itemprop="name">Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy.</div> </a> <div itemprop="about">Cancer gene therapy</div> <div itemprop="author">Boczkowski D,Lee J,Pruitt S,Nair S</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to show significantly enhanced tumor immunity through vaccination with a combination of anti-GITR-secreting dendritic cells and tumor antigen-presenting dendritic cells, providing an effective tumor vaccine adjuvant.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19155483"> <div itemprop="name">The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Cen O,Ueda A,Guzman L,Jain J,Bassiri H,Nichols KE,Stein PL</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the mechanism by which signalling lymphocytic activation molecule-associated protein exerts control over natural killer T cell development and cytokine production.</div> <div itemprodp="datePublished">Sun Feb 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19299708"> <div itemprop="name">4-1BB functions as a survival factor in dendritic cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Choi BK,Kim YH,Kwon PM,Lee SC,Kang SW,Kim MS,Lee MJ,Kwon BS</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the function of CD137 on dendritic cells, showing that it functions as a survival factor.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19582872"> <div itemprop="name">Scalable analysis of flow cytometry data using R/Bioconductor.</div> </a> <div itemprop="about">Cytometry. Part A : the journal of the International Society for Analytical Cytology</div> <div itemprop="author">Klinke DJ,Brundage KM</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate usage of a platform for the graphical and data analysis of flow cytometry data.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18952296"> <div itemprop="name">Nylon wool purification alters the activation of T cells.</div> </a> <div itemprop="about">Molecular immunology</div> <div itemprop="author">Wohler JE,Barnum SR</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to examine the effects of nylon wool purification on T cell proliferation, activation marker expression and cytokine production.</div> <div itemprodp="datePublished">Sun Feb 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19528221"> <div itemprop="name">Impact of preexisting vector-specific immunity on vaccine potency: characterization of listeria monocytogenes-specific humoral and cellular immunity in humans and modeling studies using recombinant vaccines in mice.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Leong ML,Hampl J,Liu W,Mathur S,Bahjat KS,Luckett W,Dubensky TW,Brockstedt DG</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to establish the level of L. monocytogenes-specific cellular immunity in healthy adults and support the protocol of repeated L. monocytogenes vaccination regimens to elicit a desired therapeutic effect.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19759824"> <div itemprop="name">Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Chen G,Han G,Feng J,Wang J,Wang R,Xu R,Shen B,Qian J,Li Y</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate how structural analysis of epitopes may aid predictions of protective epitopes to expand functional Tregs.</div> <div itemprodp="datePublished">Sun Sep 13 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18757428"> <div itemprop="name">Nitric oxide is a key component in inflammation-accelerated tumorigenesis.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Hussain SP,He P,Subleski J,Hofseth LJ,Trivers GE,Mechanic L,Hofseth AB,Bernard M,Schwank J,Nguyen G,Mathe E,Djurickovic D,Haines D,Weiss J,Back T,Gruys E,Laubach VE,Wiltrout RH,Harris CC</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to test the hypothesis that an inflammatory microenvironment with an enhanced level of nitric oxide accelerates spontaneous tumour development (tumorigenesis).</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18453626"> <div itemprop="name">H2E-derived Ealpha52-68 peptide presented by H2Ab interferes with clonal deletion of autoreactive T cells in autoimmune thyroiditis.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Brown NK,McCormick DJ,David CS,Kong YC</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the role of H2E-derived Ealpha52-68 peptide in autoimmune thyroiditis.</div> <div itemprodp="datePublished">Thu May 15 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18981104"> <div itemprop="name">Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Drake PM,Nathan JK,Stock CM,Chang PV,Muench MO,Nakata D,Reader JR,Gip P,Golden KP,Weinhold B,Gerardy-Schahn R,Troy FA,Bertozzi CR</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the expression and possible function of polysialic acid in the immune system.</div> <div itemprodp="datePublished">Sat Nov 15 00:00:00 EST 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18981104"> <div itemprop="name">Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Drake PM,Nathan JK,Stock CM,Chang PV,Muench MO,Nakata D,Reader JR,Gip P,Golden KP,Weinhold B,Gerardy-Schahn R,Troy FA,Bertozzi CR</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the expression and possible function of polysialic acid in the immune system.</div> <div itemprodp="datePublished">Sat Nov 15 00:00:00 EST 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18263815"> <div itemprop="name">Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.</div> </a> <div itemprop="about">Investigative ophthalmology & visual science</div> <div itemprop="author">Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S</div> <div itemprop="description"></div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18657369"> <div itemprop="name">Psychological stress impairs the local CD8+ T cell response to mucosal HSV-1 infection and allows for increased pathogenicity via a glucocorticoid receptor-mediated mechanism.</div> </a> <div itemprop="about">Psychoneuroendocrinology</div> <div itemprop="author">Ashcraft KA,Hunzeker J,Bonneau RH</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to determine how psychological stress and associated increases in corticosterone may increase susceptibility to herpes simplex virus encephalitis.</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17959178"> <div itemprop="name">Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection.</div> </a> <div itemprop="about">International journal for parasitology</div> <div itemprop="author">Wanasen N,Xin L,Soong L</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to suggest that B cell activity enhances L. amazonensis infection by promoting T cell priming and cellular migration to the infection site.</div> <div itemprodp="datePublished">Sat Mar 01 00:00:00 EST 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18794295"> <div itemprop="name">Role of natural killer cells in modulating dendritic cell responses to Leishmania amazonensis infection.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Sanabria MX,Vargas-Inchaustegui DA,Xin L,Soong L</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to suggest differential roles of DC-NK cell cross talk at different stages of Leishmania infection.</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18212072"> <div itemprop="name">Regulatory roles of CD1d-restricted NKT cells in the induction of toxic shock-like syndrome in an animal model of fatal ehrlichiosis.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Stevenson HL,Crossley EC,Thirumalapura N,Walker DH,Ismail N</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the physiopathological roles of natural killer T cells in lethal ehrlichial infection using CD1d-deficient mice.</div> <div itemprodp="datePublished">Tue Apr 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17502664"> <div itemprop="name">RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Rossi SW,Kim MY,Leibbrandt A,Parnell SM,Jenkinson WE,Glanville SH,McConnell FM,Scott HS,Penninger JM,Jenkinson EJ,Lane PJ,Anderson G</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to demonstrate a novel role for a CD4(+)3(-) inducer cell population, showing that RANK signals regulate development of Aire-expressing epithelial cells in the thymic medulla.</div> <div itemprodp="datePublished">Mon Jun 11 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17709486"> <div itemprop="name">Novel exosome-targeted CD4+ T cell vaccine counteracting CD4+25+ regulatory T cell-mediated immune suppression and stimulating efficient central memory CD8+ CTL responses.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Hao S,Liu Y,Yuan J,Zhang X,He T,Wu X,Wei Y,Sun D,Xiang J</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to study the effects of a novel exosome-targeted CD4+ T cell vaccine.</div> <div itemprodp="datePublished">Sat Sep 01 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17404305"> <div itemprop="name">Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Millington KA,Innes JA,Hackforth S,Hinks TS,Deeks JJ,Dosanjh DP,Guyot-Revol V,Gunatheesan R,Klenerman P,Lalvani A</div> <div itemprop="description">11-0041 was used in Magnetic cell separation to assess the relationship between the profile of IFN-γ- and IL-2-secreting tuberculosis-specific T-cells and antigen load.</div> <div itemprodp="datePublished">Sun Apr 15 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17060376"> <div itemprop="name">Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.</div> </a> <div itemprop="about">Circulation</div> <div itemprop="author">Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J</div> <div itemprop="description"></div> <div itemprodp="datePublished">Tue Nov 07 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16943258"> <div itemprop="name">An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.</div> </a> <div itemprop="about">International immunology</div> <div itemprop="author">Tellier J,van Meerwijk JP,Romagnoli P</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16943258"> <div itemprop="name">An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.</div> </a> <div itemprop="about">International immunology</div> <div itemprop="author">Tellier J,van Meerwijk JP,Romagnoli P</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16954391"> <div itemprop="name">Cytosolic entry controls CD8+-T-cell potency during bacterial infection.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Bahjat KS,Liu W,Lemmens EE,Schoenberger SP,Portnoy DA,Dubensky TW,Brockstedt DG</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate microbial invasion of the cytosol as a key factor in inducing CD8+- T cell-mediated protection against L.monocytogenes.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16301633"> <div itemprop="name">Plasmacytoid dendritic cells of different origins have distinct characteristics and function: studies of lymphoid progenitors versus myeloid progenitors.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Yang GX,Lian ZX,Kikuchi K,Moritoki Y,Ansari AA,Liu YJ,Ikehara S,Gershwin ME</div> <div itemprop="description">11-0041-82 was used in Flow Cytometry to indicate that MPs are multipotential and have the capacity to develop into not only myeloid cells, but also pDCs, which have distinct characteristics and function compared to that of lymphoid origin and, therefore, imply a more important role for MP-derived pDCs in conditions where the function of lymphoid progenitors is impaired or compromised.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2005</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/15302899"> <div itemprop="name">Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Auerbuch V,Brockstedt DG,Meyer-Morse N,O'Riordan M,Portnoy DA</div> <div itemprop="description">11-0041 was used in Flow cytometry/Cell sorting to investigate the role of type I interferon receptors in viral defense using Listeria monocytogenes infection of mice as a model.</div> <div itemprodp="datePublished">Mon Aug 16 00:00:00 EDT 2004</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/15509530"> <div itemprop="name">Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Kawai H,Sato W,Yuzawa Y,Kosugi T,Matsuo S,Takei Y,Kadomatsu K,Muramatsu T</div> <div itemprop="description">11-0041 was used in Immunohistochemistry on frozen tissues to investigate the significance of the secondary effects of cisplatin on proximal tubule survival.</div> <div itemprodp="datePublished">Mon Nov 01 00:00:00 EST 2004</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/12796513"> <div itemprop="name">Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Woolf E,Xiao C,Fainaru O,Lotem J,Rosen D,Negreanu V,Bernstein Y,Goldenberg D,Brenner O,Berke G,Levanon D,Groner Y</div> <div itemprop="description">Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 24 00:00:00 EDT 2003</div> </div> </noscript> </div> <div class="border-bottom"></div> <div class="product-bioinformatics-details"> <div class="container"> <h2 class="pdp-sub-heading">Bioinformatics</h2> <div class="row"> <div class="large-span-6 medium-span-12 small-span-12"> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="proteinContent"> <strong>Protein Aliases:</strong> CD4; CD4 antigen p55; cd4a; fCD4; Leu-3; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4) </p> <p class="view-buttons" id="ptnViewBtn" ng-class="$ctrl.bioContentLines('proteinContent', 'ptnViewBtn')"> <a id="proteinViewMoreBtn" ng-click="$ctrl.bioContentViewMore('proteinViewMoreBtn', 'proteinViewLessBtn', 'proteinContent')"> View more </a> <a id="proteinViewLessBtn" ng-click="$ctrl.bioContentViewLess('proteinViewLessBtn', 'proteinViewMoreBtn', 'proteinContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="geneContent"> <strong>Gene Aliases:</strong> Cd4; L3T4; Ly-4 </p> <p class="view-buttons" id="geneViewBtn" ng-class="$ctrl.bioContentLines('geneContent', 'geneViewBtn')"> <a id="geneViewMoreBtn" ng-click="$ctrl.bioContentViewMore('geneViewMoreBtn', 'geneViewLessBtn', 'geneContent')"> View more </a> <a id="geneViewLessBtn" ng-click="$ctrl.bioContentViewLess('geneViewLessBtn', 'geneViewMoreBtn', 'geneContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="unitProContent"> <strong>UniProt ID:</strong> <a href="http://www.uniprot.org/uniprot/P06332" target="_blank">(Mouse) P06332</a> </p> <p class="view-buttons" id="unitViewBtn" ng-class="$ctrl.bioContentLines('unitProContent', 'unitViewBtn')"> <a id="unitProViewMoreBtn" ng-click="$ctrl.bioContentViewMore('unitProViewMoreBtn', 'unitProViewLessBtn', 'unitProContent')"> View more </a> <a id="unitProViewLessBtn" ng-click="$ctrl.bioContentViewLess('unitProViewLessBtn', 'unitProViewMoreBtn', 'unitProContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="entrezContent"> <strong>Entrez Gene ID:</strong> <a href="http://www.ncbi.nlm.nih.gov/gene?term=12504" target="_blank">(Mouse) 12504</a> </p> <p class="view-buttons" id="etzViewBtn" ng-class="$ctrl.bioContentLines('entrezContent', 'etzViewBtn')"> <a id="entrezViewMoreBtn" ng-click="$ctrl.bioContentViewMore('entrezViewMoreBtn', 'entrezViewLessBtn', 'entrezContent')"> View more </a> <a id="entrezViewLessBtn" ng-click="$ctrl.bioContentViewLess('entrezViewLessBtn', 'entrezViewMoreBtn', 'entrezContent')"> View less </a> </p> </div> </div> <div class="large-span-6 medium-span-12 small-span-12"> <div class="accordion" id="accordion-bioinformatics"> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseOne"> Function(s) </a> </div> <div id="collapseOne" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/glycoprotein binding"> glycoprotein binding </a> <a class="icon" href="/antibody/primary/panther/protein binding"> protein binding </a> <a class="icon" href="/antibody/primary/panther/zinc ion binding"> zinc ion binding </a> <a class="icon" href="/antibody/primary/panther/coreceptor activity"> coreceptor activity </a> <a class="icon" href="/antibody/primary/panther/enzyme binding"> enzyme binding </a> <a class="icon" href="/antibody/primary/panther/protein kinase binding"> protein kinase binding </a> <a class="icon" href="/antibody/primary/panther/protein homodimerization activity"> protein homodimerization activity </a> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseTwo"> Process(es) </a> </div> <div id="collapseTwo" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/cytokine production"> cytokine production </a> <a class="icon" href="/antibody/primary/panther/immune system process"> immune system process </a> <a class="icon" href="/antibody/primary/panther/induction by virus of host cell-cell fusion"> induction by virus of host cell-cell fusion </a> <a class="icon" href="/antibody/primary/panther/immune response"> immune response </a> <a class="icon" href="/antibody/primary/panther/cell adhesion"> cell adhesion </a> <a class="icon" href="/antibody/primary/panther/cell surface receptor signaling pathway"> cell surface receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/T cell differentiation"> T cell differentiation </a> <a class="icon" href="/antibody/primary/panther/maintenance of protein location in cell"> maintenance of protein location in cell </a> <a class="icon" href="/antibody/primary/panther/T cell activation"> T cell activation </a> <a class="icon" href="/antibody/primary/panther/T cell selection"> T cell selection </a> <a class="icon" href="/antibody/primary/panther/protein palmitoleylation"> protein palmitoleylation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of protein kinase activity"> positive regulation of protein kinase activity </a> <a class="icon" href="/antibody/primary/panther/positive regulation of peptidyl-tyrosine phosphorylation"> positive regulation of peptidyl-tyrosine phosphorylation </a> <a class="icon" href="/antibody/primary/panther/defense response to Gram-negative bacterium"> defense response to Gram-negative bacterium </a> <a class="icon" href="/antibody/primary/panther/positive regulation of calcium-mediated signaling"> positive regulation of calcium-mediated signaling </a> <a class="icon" href="/antibody/primary/panther/regulation of T cell activation"> regulation of T cell activation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell activation"> positive regulation of T cell activation </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="recommended-products border-bottom hidden">  It has to be done as per old AB suggested Products section. </div> <script type="text/javascript" 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CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of GK1.5 is blocked by RM4-5.<br /><br />Applications Reported: The GK1.5 antibody has been reported for use in flow cytometric analysis.<br /><br />Applications Tested: This GK1.5 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.25 µg per test A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.<br /><br />Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.<br /><br />Filtration: 0.2 µm post-manufacturing filtered.'; THERMO_FISHER.pdp.productOrderComponent.imageForSchemaMarkup = 'https://www.thermofisher.com/antibody/images/650/11-0041-82CD4Flow1_20201009083253.jpg?time=20240507?time=20240507'; THERMO_FISHER.pdp.productOrderComponent.productSpecificationTableData = '[{"name":"Species Reactivity","value":"Mouse "},{"name":"Published species","value":"Fish ,Human ,Mouse ,Rat "},{"name":"Host / Isotype","value":"Rat/ IgG2b, kappa"},{"name":"Recommended Isotype Control","value":"Rat IgG2b kappa Isotype Control (eB149/10H5), FITC, eBioscience™"},{"name":"Class","value":"Monoclonal"},{"name":"Type","value":"Antibody"},{"name":"Clone","value":"GK1.5"},{"name":"Conjugate","value":"FITC "},{"name":"Excitation/Emission Max","value":"498/517 nm "},{"name":"Form","value":"Liquid"},{"name":"Concentration","value":"0.5 mg/mL"},{"name":"Purification","value":"Affinity chromatography"},{"name":"Storage buffer","value":"PBS, pH 7.2"},{"name":"Contains","value":"0.09% sodium azide"},{"name":"Storage conditions","value":"4° C, store in dark, DO NOT FREEZE!"},{"name":"Shipping conditions","value":"Ambient (domestic); Wet ice (international)"},{"name":"RRID","value":"AB_464892"}]'; $m.userKey = "NONE"; angular.element(document).ready(function() { angular.bootstrap('#pdp-components', ['antibodyPdpModule']); }); THERMO_FISHER.pdp.sharedListComponent = THERMO_FISHER.pdp.sharedListComponent || {}; THERMO_FISHER.pdp.sharedListComponent.sharedList = null; </script> </div> <div class="documents"> <div class="documents-cntr" id="documents-container"> <div class="loading-wheel-lg hidden" id="documentLoadingWheel"></div> <div id="documentsUIRoot1"></div> </div>  <script defer type="text/javascript" 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