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.ambox{display:none!important}}</style><table class="box-Undisclosed_paid plainlinks metadata ambox ambox-delete" role="presentation"><tbody><tr><td class="mbox-image"><div class="mbox-image-div"><span typeof="mw:File"><a href="/wiki/File:Coin_Icon.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/98/Coin_Icon.svg/50px-Coin_Icon.svg.png" decoding="async" width="50" height="30" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/98/Coin_Icon.svg/75px-Coin_Icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/98/Coin_Icon.svg/100px-Coin_Icon.svg.png 2x" data-file-width="125" data-file-height="75" /></a></span></div></td><td class="mbox-text"><div class="mbox-text-span">This article <b>may have been created or edited in return for undisclosed payments</b>, a violation of Wikipedia's <a href="https://foundation.wikimedia.org/wiki/Terms_of_Use/en#paid-contrib-disclosure" class="extiw" title="wmf:Terms of Use/en">terms of use</a>. It may require cleanup to comply with Wikipedia's <a href="/wiki/Wikipedia:List_of_policies#Content" title="Wikipedia:List of policies">content policies</a>, particularly <a href="/wiki/Wikipedia:Neutral_point_of_view" title="Wikipedia:Neutral point of view">neutral point of view</a>. <span class="date-container"><i>(<span class="date">September 2017</span>)</i></span></div></td></tr></tbody></table> <p><b>Lunasin</b> is a <a href="/wiki/Peptide" title="Peptide">peptide</a> found in soy and some cereal grains that, since 1996, has been the subject of research focusing on <a href="/wiki/Cancer" title="Cancer">cancer</a>, <a href="/wiki/Cholesterol" title="Cholesterol">cholesterol</a> and <a href="/wiki/Cardiovascular_disease" title="Cardiovascular disease">cardiovascular disease</a> and <a href="/wiki/Inflammation" title="Inflammation">inflammation</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Discovery">Discovery</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lunasin&action=edit&section=1" title="Edit section: Discovery"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Lunasin is a peptide that can be found in <a href="/wiki/Soy" class="mw-redirect" title="Soy">soy</a>, <a href="/wiki/Barley" title="Barley">barley</a>, <a href="/wiki/Wheat" title="Wheat">wheat</a>,<sup id="cite_ref-Lumen_2-0" class="reference"><a href="#cite_note-Lumen-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/Rye" title="Rye">rye</a>. It is also found in grains originating in the American continents, such as <i><a href="/wiki/Amaranthus_hypochondriacus" title="Amaranthus hypochondriacus">Amaranthus hypochondriacus</a></i>.<sup id="cite_ref-Cholone_3-0" class="reference"><a href="#cite_note-Cholone-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> This polypeptide was originally isolated, purified, and sequenced from soybean seed in 1987. Although uncertain about the peptide’s biological activity, the Japanese team of researchers described it as a 43-amino acid peptide, noting specifically the unusual poly (L-<a href="/wiki/Aspartic_acid" title="Aspartic acid">aspartic acid</a>) sequence at the carboxyl terminus.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid14769542_5-0" class="reference"><a href="#cite_note-pmid14769542-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Subsequent research by Alfredo Galvez in the laboratory of Ben de Lumen at the <a href="/wiki/University_of_California%E2%80%93Berkeley" class="mw-redirect" title="University of California–Berkeley">University of California–Berkeley</a> identified the peptide as a subunit of the <a href="/wiki/Cotyledon" title="Cotyledon">cotyledon</a>-specific 2S albumin.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The name of the protein was chosen from the Filipino word <i>lunas</i>, which means "cure".<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11606382_8-0" class="reference"><a href="#cite_note-pmid11606382-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Lunasin was patented as a biologic molecule in 1999 by de Lumen and Galvez.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Medical_research">Medical research</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lunasin&action=edit&section=2" title="Edit section: Medical research"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The biological activity of lunasin was discovered by Galvez while working in the laboratory of de Lumen at UC Berkeley.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>There has been much research interest in the biomedical aspects of lunasin but the high cost of synthesizing lunasin made experimentation difficult.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> This limitation has been overcome by the development of methods to isolate highly purified lunasin from soybean white flake, a byproduct of soybean processing.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> In laboratory and animal experiments lunasin has shown anti-carcinogenic activity that suggests it may have <a href="/wiki/Chemopreventive" class="mw-redirect" title="Chemopreventive">chemopreventive</a> potential.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="ALS_treatment">ALS treatment</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lunasin&action=edit&section=3" title="Edit section: ALS treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In 2014, a local news program reported that a person with <a href="/wiki/ALS" title="ALS">ALS</a> named Mike McDuff had experienced dramatic improvements in speech, swallowing and limb strength while taking a supplement regimen containing lunasin.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> ALSUntangled<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> investigated and was able to confirm that Mike McDuff had progressive muscular atrophy, a "lower motor neuron" form of ALS, and really did experience dramatic and objective improvements.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> Since one possible explanation for these improvements was the use of lunasin, Dr. Richard Bedlack of the Duke ALS Clinic decided to perform a clinical trial. Fifty people with ALS were put on the exact Lunasin containing regimen that Mike McDuff had taken and were followed for a year. The trial finished in September 2017. Unfortunately, there was no evidence that lunasin slowed, stopped or reversed ALS in any of the trial participants. Gastrointestinal side effects were more common than expected in trial participants, including cases of constipation severe enough to warrant hospitalization.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> Bedlack concluded that lunasin was not a useful treatment for ALS and that Mike McDuff likely had some other explanation for his ALS reversal such as an ALS mimic syndrome or a genetic resistance to the disease.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lunasin&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 30em;"> <ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFFernández-ToméHernández-Ledesma2019" class="citation journal cs1">Fernández-Tomé, Samuel; Hernández-Ledesma, Blanca (February 2019). "Current state of art after twenty years of the discovery of bioactive peptide lunasin". <i>Food Research International</i>. <b>116</b>: 71–78. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.foodres.2018.12.029">10.1016/j.foodres.2018.12.029</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30716999">30716999</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:73449759">73449759</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Food+Research+International&rft.atitle=Current+state+of+art+after+twenty+years+of+the+discovery+of+bioactive+peptide+lunasin&rft.volume=116&rft.pages=71-78&rft.date=2019-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A73449759%23id-name%3DS2CID&rft_id=info%3Apmid%2F30716999&rft_id=info%3Adoi%2F10.1016%2Fj.foodres.2018.12.029&rft.aulast=Fern%C3%A1ndez-Tom%C3%A9&rft.aufirst=Samuel&rft.au=Hern%C3%A1ndez-Ledesma%2C+Blanca&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALunasin" class="Z3988"></span></span> </li> <li id="cite_note-Lumen-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-Lumen_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDe_Lumen2008" class="citation journal cs1">De Lumen, BO (2008). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjaoac%2F91.4.932">"Lunasin: A novel cancer preventive seed peptide that modifies chromatin"</a>. <i>Journal of AOAC International</i>. <b>91</b> (4): 932–5. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjaoac%2F91.4.932">10.1093/jaoac/91.4.932</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18727555">18727555</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Lunasin%3A+A+novel+cancer+preventive+seed+peptide+that+modifies+chromatin&rft.volume=91&rft.issue=4&rft.pages=932-5&rft.date=2008&rft_id=info%3Adoi%2F10.1093%2Fjaoac%2F91.4.932&rft_id=info%3Apmid%2F18727555&rft.aulast=De+Lumen&rft.aufirst=BO&rft_id=https%3A%2F%2Fdoi.org%2F10.1093%252Fjaoac%252F91.4.932&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALunasin" class="Z3988"></span></span> </li> <li id="cite_note-Cholone-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-Cholone_3-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNakurteKlavinsKirhnereNamniece2012" class="citation journal cs1">Nakurte, Ilva; Klavins, Kristaps; Kirhnere, Inga; Namniece, Jana; Adlere, Liene; Matvejevs, Jaroslavs; Kronberga, Arta; Kokare, Aina; et al. (2012). "Discovery of lunasin peptide in triticale (X Triticosecale Wittmack)". <i>Journal of Cereal Science</i>. <b>56</b> (2): 510. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jcs.2012.04.004">10.1016/j.jcs.2012.04.004</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Cereal+Science&rft.atitle=Discovery+of+lunasin+peptide+in+triticale+%28X+Triticosecale+Wittmack%29&rft.volume=56&rft.issue=2&rft.pages=510&rft.date=2012&rft_id=info%3Adoi%2F10.1016%2Fj.jcs.2012.04.004&rft.aulast=Nakurte&rft.aufirst=Ilva&rft.au=Klavins%2C+Kristaps&rft.au=Kirhnere%2C+Inga&rft.au=Namniece%2C+Jana&rft.au=Adlere%2C+Liene&rft.au=Matvejevs%2C+Jaroslavs&rft.au=Kronberga%2C+Arta&rft.au=Kokare%2C+Aina&rft.au=Strazdina%2C+Vija&rft.au=Legzdina%2C+Linda&rft.au=Muceniece%2C+Ruta&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALunasin" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOdaniKoideOno1987" class="citation journal cs1">Odani, S; Koide, T; Ono, T (1987). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2818%2960989-5">"Amino acid sequence of a soybean (Glycine max) seed polypeptide having a poly(L-aspartic acid) structure"</a>. <i>The Journal of Biological Chemistry</i>. <b>262</b> (22): 10502–5. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2818%2960989-5">10.1016/S0021-9258(18)60989-5</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3611081">3611081</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Amino+acid+sequence+of+a+soybean+%28Glycine+max%29+seed+polypeptide+having+a+poly%28L-aspartic+acid%29+structure&rft.volume=262&rft.issue=22&rft.pages=10502-5&rft.date=1987&rft_id=info%3Adoi%2F10.1016%2FS0021-9258%2818%2960989-5&rft_id=info%3Apmid%2F3611081&rft.aulast=Odani&rft.aufirst=S&rft.au=Koide%2C+T&rft.au=Ono%2C+T&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0021-9258%252818%252960989-5&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALunasin" class="Z3988"></span></span> </li> <li id="cite_note-pmid14769542-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid14769542_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLamGalvezDe_Lumen2003" class="citation journal cs1">Lam, Yi; Galvez, Alfredo; De Lumen, Ben O. (2003). 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Archived from <a rel="nofollow" class="external text" href="http://nst.berkeley.edu/faculty/delumen.html">the original</a> on November 24, 2012<span class="reference-accessdate">. Retrieved <span class="nowrap">November 29,</span> 2012</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Lunasin%3A+a+Cancer+Preventive+Peptide+in+Seeds&rft.pub=University+of+California%2C+Berkeley&rft_id=http%3A%2F%2Fnst.berkeley.edu%2Ffaculty%2Fdelumen.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALunasin" class="Z3988"></span></span> </li> <li id="cite_note-pmid11606382-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11606382_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGalvezChenMacasiebde_Lumen2001" class="citation journal cs1">Galvez, Alfredo F.; Chen, Na; Macasieb, Janet; de Lumen, Ben O. (2001). <a rel="nofollow" class="external text" href="http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=11606382">"Chemopreventive Property of a Soybean Peptide (Lunasin) That Binds to Deacetylated Histones and Inhibits Acetylation"</a>. <i>Cancer Research</i>. <b>61</b> (20): 7473–8. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11606382">11606382</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Chemopreventive+Property+of+a+Soybean+Peptide+%28Lunasin%29+That+Binds+to+Deacetylated+Histones+and+Inhibits+Acetylation&rft.volume=61&rft.issue=20&rft.pages=7473-8&rft.date=2001&rft_id=info%3Apmid%2F11606382&rft.aulast=Galvez&rft.aufirst=Alfredo+F.&rft.au=Chen%2C+Na&rft.au=Macasieb%2C+Janet&rft.au=de+Lumen%2C+Ben+O.&rft_id=http%3A%2F%2Fcancerres.aacrjournals.org%2Fcgi%2Fpmidlookup%3Fview%3Dlong%26pmid%3D11606382&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALunasin" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://patents.google.com/patent/WO1999015642A1/un">"Patent: Lunasin peptides, WO 1999015642 A1"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Patent%3A+Lunasin+peptides%2C+WO+1999015642+A1&rft_id=https%3A%2F%2Fpatents.google.com%2Fpatent%2FWO1999015642A1%2Fun&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALunasin" class="Z3988"></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDe_LumenGalvez1999" class="citation journal cs1">De Lumen, Benito O.; Galvez, Alfredo F. 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Archived from <a rel="nofollow" class="external text" href="http://www.alsreversals.com/star.html">the original</a> on 2015-04-21.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.alsreversals.com&rft.atitle=ALS+Reversals+-+St.A.R.&rft_id=http%3A%2F%2Fwww.alsreversals.com%2Fstar.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALunasin" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lunasin&action=edit&section=5" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://Lunasin.com">Lunasin research repository</a></li> <li><a rel="nofollow" class="external text" href="http://Lunamd.com">LunaMD Lunasin</a></li></ul> <p><br /> </p> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output 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.navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Soy_(Glycine_max)" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Soy" title="Template:Soy"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Soy" title="Template talk:Soy"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Soy" title="Special:EditPage/Template:Soy"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Soy_(Glycine_max)" style="font-size:114%;margin:0 4em"><a href="/wiki/Soybean" title="Soybean">Soy</a> (<i>Glycine max</i>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">General</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Soy_allergy" title="Soy allergy">Soy allergy</a></li> <li><a href="/wiki/Soy_candle" title="Soy candle">Soy candle</a></li> <li><a href="/wiki/Soy_ink" title="Soy ink">Soy ink</a></li> <li><a href="/wiki/Soy_molasses" title="Soy molasses">Soy molasses</a></li> <li><a href="/wiki/Soy_paint" title="Soy paint">Soy paint</a></li> <li><a href="/wiki/Soy_protein" title="Soy protein">Soy protein</a></li> <li><a href="/wiki/Soybean" title="Soybean">Soybean</a></li> <li><a href="/wiki/List_of_soybean_diseases" title="List of soybean diseases">Diseases</a></li> <li><a href="/wiki/Soybean_meal" title="Soybean meal">Soybean meal</a></li> <li><a href="/wiki/Soybean_oil" title="Soybean oil">Soybean oil</a></li></ul> </div></td><td class="noviewer navbox-image" rowspan="9" style="width:1px;padding:0 0 0 2px"><div><span typeof="mw:File"><a href="/wiki/File:Soybean.USDA.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Soybean.USDA.jpg/80px-Soybean.USDA.jpg" decoding="async" width="80" height="119" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Soybean.USDA.jpg/120px-Soybean.USDA.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/82/Soybean.USDA.jpg/160px-Soybean.USDA.jpg 2x" data-file-width="640" data-file-height="951" /></a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Soy-based<br />dishes</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/List_of_soy-based_foods" title="List of soy-based foods">List of soy-based foods</a></li> <li><a href="/wiki/Aburaage" class="mw-redirect" title="Aburaage">Aburaage</a></li> <li><a href="/wiki/Agedashi_tofu" class="mw-redirect" title="Agedashi tofu">Agedashi tofu</a></li> <li><a href="/wiki/Bai_ye" class="mw-redirect" title="Bai ye">Bai ye</a></li> <li><a href="/wiki/Douhua" title="Douhua">Douhua</a></li> <li><a href="/wiki/Dubu_kimchi" class="mw-redirect" title="Dubu kimchi">Dubu kimchi</a></li> <li><a href="/wiki/Edamame" title="Edamame">Edamame</a></li> <li><a href="/wiki/Hiyayakko" title="Hiyayakko">Hiyayakko</a></li> <li><a href="/wiki/Kongguksu" class="mw-redirect" title="Kongguksu">Kongguksu</a></li> <li><a href="/wiki/Kongnamul" class="mw-redirect" title="Kongnamul">Kongnamul</a></li> <li><a href="/wiki/Mapo_doufu" class="mw-redirect" title="Mapo doufu">Mapo doufu</a></li> <li><a href="/wiki/Miso_soup" title="Miso soup">Miso soup</a></li> <li><a href="/wiki/Sundubu_jjigae" class="mw-redirect" title="Sundubu jjigae">Sundubu jjigae</a></li> <li><a href="/wiki/Tahu_goreng" title="Tahu goreng">Tahu goreng</a></li> <li><a href="/wiki/Tofu_skin_roll" title="Tofu skin roll">Tofu skin roll</a></li> <li><a href="/wiki/Yong_tau_foo" title="Yong tau foo">Yong tau foo</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Plant_milk" title="Plant milk">Plant milk</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Soy_milk" title="Soy milk">Soy milk</a></li> <li><a href="/wiki/Soy_yogurt" title="Soy yogurt">Soy yogurt</a></li> <li><a href="/wiki/Vegan_cheese" title="Vegan cheese">Vegan cheese</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Meat_analogue" class="mw-redirect" title="Meat analogue">Meat analogues</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Beanfeast" title="Beanfeast">Beanfeast</a></li> <li><a href="/wiki/Tempeh" title="Tempeh">Tempeh</a></li> <li><a href="/wiki/Textured_vegetable_protein" title="Textured vegetable protein">Textured vegetable protein</a></li> <li><a href="/wiki/Tofu" title="Tofu">Tofu</a></li> <li><a href="/wiki/Tofurkey" title="Tofurkey">Tofurkey</a></li> <li><a href="/wiki/Vegetarian_hot_dog" title="Vegetarian hot dog">Vegetarian hot dog</a></li> <li><a href="/wiki/Veggie_burger" title="Veggie burger">Veggie burger</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Sauces and<br />condiments</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Soy_sauce" title="Soy sauce">Soy sauce</a> based</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ganjang" class="mw-redirect" title="Ganjang">Ganjang</a></li> <li><a href="/wiki/Ponzu" title="Ponzu">Ponzu</a></li> <li><a href="/wiki/Sweet_soy_sauce" title="Sweet soy sauce">Sweet soy sauce</a></li> <li><a href="/wiki/Soy_sauce#Japanese" title="Soy sauce">Tamari</a></li> <li><a href="/wiki/Teriyaki" title="Teriyaki">Teriyaki</a></li> <li>Tsuyu</li> <li>Yìn yóu</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Pastes</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Doenjang" title="Doenjang">Doenjang</a></li> <li><a href="/wiki/Doubanjiang" title="Doubanjiang">Doubanjiang</a></li> <li><a href="/wiki/Miso" title="Miso">Miso</a></li> <li><a href="/wiki/Sweet_bean_sauce" class="mw-redirect" title="Sweet bean sauce">Sweet bean sauce</a></li> <li><a href="/wiki/Yellow_soybean_paste" title="Yellow soybean paste">Yellow soybean paste</a></li> <li><a href="/wiki/T%C6%B0%C6%A1ng" title="Tương">Tương</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Fermented bean</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Akhuni" title="Akhuni">Akhuni</a></li> <li><a href="/wiki/Fermented_bean_curd" title="Fermented bean curd">Fermented bean curd</a></li> <li><a href="/wiki/Douchi" title="Douchi">Douchi</a></li> <li><a href="/wiki/Kinema" title="Kinema">Kinema</a></li> <li><a href="/wiki/Tauco" title="Tauco">Tauco</a></li> <li><a href="/wiki/Natt%C5%8D" title="Nattō">Nattō</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other foods</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mamenori" title="Mamenori">Mamenori</a></li> <li><a href="/wiki/Mao_tofu" title="Mao tofu">Mao tofu</a></li> <li><a href="/wiki/Oncom" title="Oncom">Oncom</a></li> <li><a href="/wiki/Soybean#Flour" title="Soybean">Soy flour</a></li> <li><a href="/wiki/Soybean#Infant_formula" title="Soybean">Soy milk based infant formula</a></li> <li><a href="/wiki/Soy_nut" title="Soy nut">Soy nut</a></li> <li><a href="/wiki/Soy_pulp" class="mw-redirect" title="Soy pulp">Soy pulp</a></li> <li><a href="/wiki/Stinky_tofu" title="Stinky tofu">Stinky tofu</a></li> <li><a href="/wiki/Tofu_skin" title="Tofu skin">Tofu skin</a></li> <li><a href="/wiki/List_of_fermented_soy_products" title="List of fermented soy products">List of fermented soy products</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Biochemicals</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Phytoestrogens" class="mw-redirect" title="Phytoestrogens">Phytoestrogens</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Genistein" title="Genistein">Genistein</a></li> <li><a href="/wiki/Genistin" title="Genistin">Genistin</a></li> <li><a href="/wiki/Glycitein" title="Glycitein">Glycitein</a></li> <li><a href="/wiki/Glycitin" title="Glycitin">Glycitin</a></li> <li><a href="/wiki/Ononin" title="Ononin">Ononin</a></li> <li><a href="/wiki/Daidzein" title="Daidzein">Daidzein</a></li> <li><a href="/wiki/Equol" title="Equol">Equol</a> (metabolite)</li> <li><a href="/wiki/O-Desmethylangolensin" title="O-Desmethylangolensin">O-DMA</a> (metabolite)</li> <li><a href="/wiki/Daidzin" title="Daidzin">Daidzin</a> (leaves)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Globulins (proteins)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Beta-conglycinin&action=edit&redlink=1" class="new" title="Beta-conglycinin (page does not exist)">Beta-conglycinin</a></li> <li><a href="/w/index.php?title=Glycinin&action=edit&redlink=1" class="new" title="Glycinin (page does not exist)">Glycinin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Phytohaemagglutinin" title="Phytohaemagglutinin">PHAs</a> (<a href="/wiki/Lectin" title="Lectin">lectins</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Soybean_agglutinin" title="Soybean agglutinin">Soybean agglutinin</a> (lectin)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Enzymes</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Beta-amylase" class="mw-redirect" title="Beta-amylase">Beta-amylase</a></li> <li><a href="/wiki/Lipoxygenase" title="Lipoxygenase">Lipoxygenase</a></li> <li><a href="/wiki/Cysteine_protease" title="Cysteine protease">Cysteine proteases</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Trypsin_inhibitor" title="Trypsin inhibitor">Trypsin inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Kunitz_inhibitor&action=edit&redlink=1" class="new" title="Kunitz inhibitor (page does not exist)">Kunitz inhibitor</a></li> <li><a href="/w/index.php?title=Bowman-Birk_inhibitor&action=edit&redlink=1" class="new" title="Bowman-Birk inhibitor (page does not exist)">Bowman-Birk inhibitor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Soy_lecithin" class="mw-redirect" title="Soy lecithin">Soy lecithin</a> (mix of <a href="/wiki/Phospholipid" title="Phospholipid">Phospholipids</a>)</li> <li><a class="mw-selflink selflink">Lunasin</a></li> <li><a href="/wiki/Unsaponifiable" class="mw-redirect" title="Unsaponifiable">Unsaponifiables</a> <ul><li><a href="/wiki/Tocopherol" title="Tocopherol">Tocopherols</a></li> <li><a href="/wiki/Sterols" class="mw-redirect" title="Sterols">Sterols</a></li></ul></li> <li><a href="/wiki/Antinutrient" title="Antinutrient">Antinutrients</a> <ul><li><a href="/wiki/Phytates" class="mw-redirect" title="Phytates">Phytates</a></li></ul></li> <li><a href="/wiki/Protease_Inhibitors" class="mw-redirect" title="Protease Inhibitors">Protease Inhibitors</a> <ul><li><a href="/wiki/Cystatin" title="Cystatin">Cystatins</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Companies</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/8th_Continent" title="8th Continent">8th Continent</a></li> <li><a href="/wiki/Alpro" title="Alpro">Alpro</a></li> <li><a href="/wiki/Boca_Burger" title="Boca Burger">Boca Burger</a></li> <li><a href="/wiki/Gardenburger" title="Gardenburger">Gardenburger</a></li> <li><a href="/wiki/Kikkoman" title="Kikkoman">Kikkoman</a></li> <li><a href="/wiki/Morningstar_Farms" title="Morningstar Farms">Morningstar Farms</a></li> <li><a href="/wiki/Mr_Bean_(company)" title="Mr Bean (company)">Mr Bean</a></li> <li><a href="/wiki/Plamil_Foods" title="Plamil Foods">Plamil Foods</a></li> <li><a href="/wiki/Silk_(brand)" title="Silk (brand)">Silk</a></li> <li><a href="/wiki/So_Good_(soy_beverage)" class="mw-redirect" title="So Good (soy beverage)">So Good</a></li> <li><a href="/wiki/Tofutti" title="Tofutti">Tofutti</a></li> <li><a href="/wiki/Vitasoy" title="Vitasoy">Vitasoy</a></li> <li><a href="/wiki/Yamasa" title="Yamasa">Yamasa</a></li> <li><a href="/wiki/Yeo_Hiap_Seng" title="Yeo Hiap Seng">Yeo Hiap Seng</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Diet_for_a_Small_Planet" title="Diet for a Small Planet">Diet for a Small Planet</a></i></li> <li><a href="/wiki/Kikkoman_Soy_Sauce_Museum" title="Kikkoman Soy Sauce Museum">Kikkoman Soy Sauce Museum</a></li> <li><a href="/wiki/William_Shurtleff" title="William Shurtleff">William Shurtleff</a> and <a href="/wiki/Akiko_Aoyagi" title="Akiko Aoyagi">Akiko Aoyagi</a></li> <li><a href="/wiki/Yuasa,_Wakayama" title="Yuasa, Wakayama">Yuasa</a>, artisan town of historic soy sauce distilleries</li></ul> </div></td></tr><tr><td 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