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There are three major types of protein A “resin” based on a different matrix chemistries – glass, agarose and synthetic polymer. State of the art resins must offer good specificity, high mass transfer and binding capacity, low non-specific adsorption, low ligand leakage, suitable back pressure under high flow operation, and good chemical stability – particularly during alkaline sanitization." /> <link rel="canonical" href="https://biopharma-asia.com/technical-papers/comparison-purification-performance-amsphere-a3-commercially-available-protein-resins/" /> <meta property="og:locale" content="en_GB" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Comparison of purification performance of Amsphere A3 to other commercially available Protein A resins" /> <meta property="og:description" content="Protein A affinity chromatography represents the key initial capture method in monoclonal antibody (mAb) purification. There are three major types of protein A “resin” based on a different matrix chemistries – glass, agarose and synthetic polymer. State of the art resins must offer good specificity, high mass transfer and binding capacity, low non-specific adsorption, low ligand leakage, suitable back pressure under high flow operation, and good chemical stability – particularly during alkaline sanitization." /> <meta property="og:url" content="https://biopharma-asia.com/technical-papers/comparison-purification-performance-amsphere-a3-commercially-available-protein-resins/" /> <meta property="og:site_name" content="Biopharma Asia" /> <meta property="article:publisher" content="https://www.facebook.com/BioPharma-Asia-1583990648542779/" /> <meta property="article:modified_time" content="2018-04-06T10:38:41+00:00" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@Biopharma_asia" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebPage","@id":"https://biopharma-asia.com/technical-papers/comparison-purification-performance-amsphere-a3-commercially-available-protein-resins/","url":"https://biopharma-asia.com/technical-papers/comparison-purification-performance-amsphere-a3-commercially-available-protein-resins/","name":"Comparison of purification performance of Amsphere A3 to other commercially available Protein A resins","isPartOf":{"@id":"https://biopharma-asia.com/#website"},"datePublished":"2017-01-19T15:02:09+00:00","dateModified":"2018-04-06T10:38:41+00:00","description":"Protein A affinity chromatography represents the key initial capture method in monoclonal antibody (mAb) purification. There are three major types of protein A “resin” based on a different matrix chemistries – glass, agarose and synthetic polymer. State of the art resins must offer good specificity, high mass transfer and binding capacity, low non-specific adsorption, low ligand leakage, suitable back pressure under high flow operation, and good chemical stability – particularly during alkaline sanitization.","breadcrumb":{"@id":"https://biopharma-asia.com/technical-papers/comparison-purification-performance-amsphere-a3-commercially-available-protein-resins/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https://biopharma-asia.com/technical-papers/comparison-purification-performance-amsphere-a3-commercially-available-protein-resins/"]}]},{"@type":"BreadcrumbList","@id":"https://biopharma-asia.com/technical-papers/comparison-purification-performance-amsphere-a3-commercially-available-protein-resins/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://biopharma-asia.com/"},{"@type":"ListItem","position":2,"name":"Technical Papers","item":"https://biopharma-asia.com/technical-papers/"},{"@type":"ListItem","position":3,"name":"Comparison of purification performance of Amsphere A3 to other commercially available Protein A resins"}]},{"@type":"WebSite","@id":"https://biopharma-asia.com/#website","url":"https://biopharma-asia.com/","name":"Biopharma Asia","description":"","publisher":{"@id":"https://biopharma-asia.com/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://biopharma-asia.com/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https://biopharma-asia.com/#organization","name":"Biopharma Asia","url":"https://biopharma-asia.com/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https://biopharma-asia.com/#/schema/logo/image/","url":"https://biopharma-asia.com/wp-content/uploads/2018/02/logo-biopharma-asia.png","contentUrl":"https://biopharma-asia.com/wp-content/uploads/2018/02/logo-biopharma-asia.png","width":186,"height":72,"caption":"Biopharma Asia"},"image":{"@id":"https://biopharma-asia.com/#/schema/logo/image/"},"sameAs":["https://www.facebook.com/BioPharma-Asia-1583990648542779/","https://x.com/Biopharma_asia","https://www.linkedin.com/company/biopharmalibrary.com"]}]}</script>  <link rel='dns-prefetch' href='//fonts.googleapis.com' /> <link rel='stylesheet' id='subscribers-css' href='https://biopharma-asia.com/wp-content/plugins/subscribers/css/styles.css?ver=6.6' type='text/css' media='all' /> <link rel='stylesheet' id='wp-block-library-css' href='https://biopharma-asia.com/wp-includes/css/dist/block-library/style.min.css?ver=6.6' type='text/css' media='all' /> <style id='classic-theme-styles-inline-css' type='text/css'> /*! 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href="https://biopharma-asia.com" class="home"><span property="name">Biopharma Asia</span></a><meta property="position" content="1"></span> > <span property="itemListElement" typeof="ListItem"><a property="item" typeof="WebPage" title="Go to Technical Papers." href="https://biopharma-asia.com/technical-papers/" class="archive post-technical_paper-archive"><span property="name">Technical Papers</span></a><meta property="position" content="2"></span> > <span property="itemListElement" typeof="ListItem"><a property="item" typeof="WebPage" title="Go to Comparison of purification performance of Amsphere A3 to other commercially available Protein A resins." href="https://biopharma-asia.com/technical-papers/comparison-purification-performance-amsphere-a3-commercially-available-protein-resins/" class="post post-technical_paper current-item"><span property="name">Comparison of purification performance of Amsphere A3 to other commercially available Protein A resins</span></a><meta property="position" content="3"></span> </div> </div> </div> </div> <section class="main-content"> <div class="container"> <div class="row"> <div class="col-sm-12"> <div class="row"> <div class="col-md-9"> <div id="hero"> <div class="gallery-item"> <a href="https://cytiva.link/zfht6" target="_blank" class="ad-main-slider-1"> <img src="https://biopharma-asia.com/wp-content/uploads/2024/10/4069_CYTIVA-Palltronic-website-Banner-940X300PX_V1.png" class="img-responsive"> </a> </div> </div> <h1 class="bold">Comparison of purification performance of Amsphere A3 to other commercially available Protein A resins</h1> <div class="blog-post-date"> <p> <em>Posted on January 19, 2017</em> </p> </div> <a href="http://jsrlifesciences.com" target="_blank"> <img src="https://biopharma-asia.com/wp-content/uploads/2016/12/jsr-1-1.png" alt="" class="img-responsive" style="max-width: 300px;"> </a> <img src="" alt="" class="img-responsive" style="max-width: 300px;"> <p>Protein A affinity chromatography represents the key initial capture method in monoclonal antibody (mAb) purification. There are three major types of protein A “resin” based on a different matrix chemistries – glass, agarose and synthetic polymer. State of the art resins must offer good specificity, high mass transfer and binding capacity, low non-specific adsorption, low ligand leakage, suitable back pressure under high flow operation, and good chemical stability – particularly during alkaline sanitization.</p> <p>Until now, selecting a protein A resin for bioprocessing applications involved balancing among high specificity, high mass transfer and binding capacity, low non-specific adsorption and ligand leakage, incompressibility, resistance to alkaline condition for sanitization, chemical stability and cost effectiveness. Recent results using new Amsphere A3 versus Polymer H and Agarose show that the Amsphere A3 design minimizes compromise in performance criteria.</p> <p> </p> <p><img fetchpriority="high" decoding="async" class="size-full wp-image-7040 alignnone" src="https://biopharma-asia.com/wp-content/uploads/2017/01/1-4.jpg" alt="" width="755" height="416" srcset="https://biopharma-asia.com/wp-content/uploads/2017/01/1-4.jpg 755w, https://biopharma-asia.com/wp-content/uploads/2017/01/1-4-300x165.jpg 300w" sizes="(max-width: 755px) 100vw, 755px" /></p> <p><em>TABLE 1: HOST CELL PROTEIN LEVEL OF LOADING SAMPLES</em></p> <p> </p> <p><strong>AmsphereTM A3</strong></p> <p> </p> <p><img loading="lazy" decoding="async" class="size-full wp-image-7041 alignnone" src="https://biopharma-asia.com/wp-content/uploads/2017/01/2-4.jpg" alt="" width="518" height="284" srcset="https://biopharma-asia.com/wp-content/uploads/2017/01/2-4.jpg 518w, https://biopharma-asia.com/wp-content/uploads/2017/01/2-4-300x164.jpg 300w" sizes="(max-width: 518px) 100vw, 518px" /></p> <p>Amsphere A3 is a new protein A resin designed with a surface modified base bead and alkali-resistant optimized ligand.</p> <p> </p> <p><strong>Protein A ligand</strong></p> <p>• High DBC via controlled conformation and orientation</p> <p>• High alkaline stability from protein engineering Surface modification</p> <p>• Low HCP levels by surface hydrophilization Base bead formulation</p> <p>• High DBC at high flow rate</p> <p>• Excellent pressure and flow properties via rigid crosslinking</p> <p> </p> <p><img loading="lazy" decoding="async" class="size-full wp-image-7042 alignnone" src="https://biopharma-asia.com/wp-content/uploads/2017/01/11-2.jpg" alt="" width="1058" height="126" srcset="https://biopharma-asia.com/wp-content/uploads/2017/01/11-2.jpg 1058w, https://biopharma-asia.com/wp-content/uploads/2017/01/11-2-300x36.jpg 300w, https://biopharma-asia.com/wp-content/uploads/2017/01/11-2-768x91.jpg 768w, https://biopharma-asia.com/wp-content/uploads/2017/01/11-2-1024x122.jpg 1024w" sizes="(max-width: 1058px) 100vw, 1058px" /></p> <p>FIGURE 1: TEST CONDITIONS OF CHROMATOGRAPHY PROCESS</p> <p> </p> <p><strong>Study Methods and Materials</strong></p> <p>Polymer (H) protein A affinity chromatography resins were tested in comparison with Amsphere A3. Five mAb samples (as in Table 1) expressed in CHO cells and clarified by centrifugation and 0.22 mm filtration were tested.. Purified polyclonal human IgG was also used. Dynamic binding capacity (DBC) at 10% breakthrough versus residence time, alkali stability (0.5 M NaOH), host cell protein (HCP) clearance, pressure-flow properties, and protein A ligand leaching were evaluated according to common literature protocols.</p> <p>The details of the protein A column chromatography processes are given in Figure 1. Other experimental details are given in association with the results below.</p> <p> </p> <p><strong>Results</strong></p> <p>1. DYNAMIC BINDING CAPACITY</p> <p><img loading="lazy" decoding="async" class="size-full wp-image-7043 alignnone" src="https://biopharma-asia.com/wp-content/uploads/2017/01/3-4.jpg" alt="" width="961" height="245" srcset="https://biopharma-asia.com/wp-content/uploads/2017/01/3-4.jpg 961w, https://biopharma-asia.com/wp-content/uploads/2017/01/3-4-300x76.jpg 300w, https://biopharma-asia.com/wp-content/uploads/2017/01/3-4-768x196.jpg 768w" sizes="(max-width: 961px) 100vw, 961px" /></p> <p> </p> <p>2. mAbs DYNAMIC BINDING CAPACITIES AT 5 MINUTES RESIDENCE TIME</p> <p><img loading="lazy" decoding="async" class="size-full wp-image-7044 alignnone" src="https://biopharma-asia.com/wp-content/uploads/2017/01/4-4.jpg" alt="" width="962" height="230" srcset="https://biopharma-asia.com/wp-content/uploads/2017/01/4-4.jpg 962w, https://biopharma-asia.com/wp-content/uploads/2017/01/4-4-300x72.jpg 300w, https://biopharma-asia.com/wp-content/uploads/2017/01/4-4-768x184.jpg 768w" sizes="(max-width: 962px) 100vw, 962px" /></p> <p>3. HCP CLEARANCE – TARGET POOL HCP LEVELS</p> <p><img loading="lazy" decoding="async" class="size-full wp-image-7045 alignnone" src="https://biopharma-asia.com/wp-content/uploads/2017/01/5-3.jpg" alt="" width="978" height="222" srcset="https://biopharma-asia.com/wp-content/uploads/2017/01/5-3.jpg 978w, https://biopharma-asia.com/wp-content/uploads/2017/01/5-3-300x68.jpg 300w, https://biopharma-asia.com/wp-content/uploads/2017/01/5-3-768x174.jpg 768w" sizes="(max-width: 978px) 100vw, 978px" /></p> <p>4. LEACHED PROTEIN A INTO TARGET POOL</p> <p><img loading="lazy" decoding="async" class="size-full wp-image-7046 alignnone" src="https://biopharma-asia.com/wp-content/uploads/2017/01/6-4.jpg" alt="" width="962" height="221" srcset="https://biopharma-asia.com/wp-content/uploads/2017/01/6-4.jpg 962w, https://biopharma-asia.com/wp-content/uploads/2017/01/6-4-300x69.jpg 300w, https://biopharma-asia.com/wp-content/uploads/2017/01/6-4-768x176.jpg 768w" sizes="(max-width: 962px) 100vw, 962px" /></p> <p>5. ALKALINE STABILITY (% RETENTION OF DBC) TO 0.5M NaOH</p> <p><img loading="lazy" decoding="async" class="size-full wp-image-7047 alignnone" src="https://biopharma-asia.com/wp-content/uploads/2017/01/7-2.jpg" alt="" width="964" height="275" srcset="https://biopharma-asia.com/wp-content/uploads/2017/01/7-2.jpg 964w, https://biopharma-asia.com/wp-content/uploads/2017/01/7-2-300x86.jpg 300w, https://biopharma-asia.com/wp-content/uploads/2017/01/7-2-768x219.jpg 768w" sizes="(max-width: 964px) 100vw, 964px" />6. PRESSURE-FLOW PROPERTIES</p> <p><img loading="lazy" decoding="async" class="size-full wp-image-7048 alignnone" src="https://biopharma-asia.com/wp-content/uploads/2017/01/8-2.jpg" alt="" width="947" height="236" srcset="https://biopharma-asia.com/wp-content/uploads/2017/01/8-2.jpg 947w, https://biopharma-asia.com/wp-content/uploads/2017/01/8-2-300x75.jpg 300w, https://biopharma-asia.com/wp-content/uploads/2017/01/8-2-768x191.jpg 768w" sizes="(max-width: 947px) 100vw, 947px" /></p> <p> </p> <p> </p> <p> </p> <p><strong>Overall Conclusion</strong></p> <p>Amsphere A3 has incorporated many resin design attributes that minimize compromise in key selection criteria such as DBC, HCP reduction, and caustic stability. The selection of ligand design, bead design and surface modification result in a superior product, fit for a wide range of operating conditions and scale.</p> <p> </p> <p>AmsphereTM is a global trademark of JSR Corporation</p> <p>©2016-2017 JSR Corporation – All rights reserved.</p> <p>For more information visit <a href="http://www.jsrlifesciences.com">www.jsrlifesciences.com</a></p> <hr> <div class='apss-social-share apss-theme-1 clearfix '> <div class='apss-facebook apss-single-icon'> <a rel='nofollow' title="Share on Facebook" target='_blank' href='https://www.facebook.com/sharer/sharer.php?u=https://biopharma-asia.com/technical-papers/comparison-purification-performance-amsphere-a3-commercially-available-protein-resins/'> <div class='apss-icon-block clearfix'> <i class='fab fa-facebook-f'></i> <span class='apss-social-text'>Share on Facebook</span> <span class='apss-share'>Share</span> </div> </a> </div> <div class='apss-twitter apss-single-icon'> <a rel='nofollow' href="https://twitter.com/intent/tweet?text=Comparison%20of%20purification%20performance%20of%20Amsphere%20A3%20to%20other%20commercially%20available%20Protein%20A%20resins&url=https://biopharma-asia.com/technical-papers/comparison-purification-performance-amsphere-a3-commercially-available-protein-resins/&" title='Share on Twitter' target='_blank'> <div class='apss-icon-block clearfix'> <i class='fab fa-twitter'></i> <span class='apss-social-text'>Share on Twitter</span><span class='apss-share'>Tweet</span> </div> </a> </div> <div class='apss-linkedin apss-single-icon'> <a rel='nofollow' title='Share on LinkedIn' target='_blank' href='http://www.linkedin.com/sharing/share-offsite/?url=https://biopharma-asia.com/technical-papers/comparison-purification-performance-amsphere-a3-commercially-available-protein-resins/'> <div class='apss-icon-block clearfix'><i class='fab fa-linkedin'></i> <span class='apss-social-text'>Share on LinkedIn</span> <span class='apss-share'>Share</span> </div> </a> </div> </div> <hr> <h1 class="bold">Related Topics and Keywords </h1><p><a href="https://biopharma-asia.com/tag/agarose/" rel="tag">agarose</a>, <a href="https://biopharma-asia.com/tag/amsphere-a3/" rel="tag">Amsphere A3</a>, <a href="https://biopharma-asia.com/tag/bioprocessing-applications/" rel="tag">bioprocessing applications</a>, <a href="https://biopharma-asia.com/tag/comparison-of-purification-performance/" rel="tag">Comparison of purification performance</a>, <a href="https://biopharma-asia.com/tag/glass/" rel="tag">glass</a>, <a href="https://biopharma-asia.com/tag/initial-capture-method/" rel="tag">initial capture method</a>, <a href="https://biopharma-asia.com/tag/jsr-life-sciences/" rel="tag">JSR Life Sciences</a>, <a href="https://biopharma-asia.com/tag/mab/" rel="tag">mAb</a>, <a href="https://biopharma-asia.com/tag/monoclonal-antibody/" rel="tag">monoclonal antibody</a>, <a href="https://biopharma-asia.com/tag/protein-a-affinity-chromatography/" rel="tag">Protein A affinity chromatography</a>, <a href="https://biopharma-asia.com/tag/protein-a-resins/" rel="tag">Protein A resins</a>, <a href="https://biopharma-asia.com/tag/purification/" rel="tag">purification</a>, <a href="https://biopharma-asia.com/tag/synthetic-polymer/" rel="tag">synthetic polymer</a></p> <div id="signup-form"> <h3><strong>Subscribe to our FREE newsletter and WEBINAR UPDATES</strong></h3> <p class="red"><strong>We will not sell or give your information to a third party. 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