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The findings, which were published online in Nature on Nov. 18, 2024, are a possible molecular-level explanation for the short-term nature of most weight loss." /> <meta name="keywords" content="BioWorld Science,obesity,ETH Zurich,weight loss,epigenetics,yo-yo effect,Endocrine/metabolic,BioWorld MedTech" /> <link rel="alternate" type="application/xml" title="BioWorld RSS Feed" href="https://www.bioworld.com/rss/articles" /> <meta property="og:title" content=" Epigenetic changes linked to weight regain" /> <meta property="og:description" content="Fat cells from patients who had lost weight after bariatric surgery, as well as from animals who had gained and then lost weight, were transcriptionally distinct from cells that had not experienced such weight changes at the organism level. In the animal studies, those transcriptional changes were due to epigenetic changes. The findings, which were published online in Nature on Nov. 18, 2024, are a possible molecular-level explanation for the short-term nature of most weight loss." /> <meta property="og:author" content="Anette Breindl" /> <meta property="og:url" content="https://www.bioworld.com/articles/714726-epigenetic-changes-linked-to-weight-regain" /> <meta property="og:image" content="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Obesity/Weight-loss-yo-yo-cycle.jpg?height=635&t=1732292895&width=1200" /> <meta property="og:image:width" content="846" /> <meta property="og:image:height" content="635" /> <meta property="og:type" content="Article" /> <meta name="twitter:title" content=" Epigenetic changes linked to weight regain" /> <meta name="twitter:description" content="Fat cells from patients who had lost weight after bariatric surgery, as well as from animals who had gained and then lost weight, were transcriptionally distinct from cells that had not experienced such weight changes at the organism level. 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Link to Cortellis page on Clarivate website." loading="lazy" src="/images/Cortellis_Flagship_Logo_TM_RGB_Color.png" /></div><h1 class="intent-popup__headline">Upgrade your daily dose of biopharma and medtech news</h1><h2 class="intent-popup__sub-headline"></h2><div class="intent-popup__content"> <p>Subscribe to BioWorld™ news services</p> </div><a class="intent-popup__link" href="https://www.bioworld.com/orders?utm_campaign=BioWorld_LS_Global_2021&utm_source=popup_banner&utm_medium=owned">See subscription options</a></div><div class="intent-popup__bg"></div></section><script>function setLocalExp(key, value, ttl) { var now = new Date() // `item` is an object which contains the original value // as well as the time when it's supposed to expire var item = { value: value, expiry: now.getTime() + ttl, } localStorage.setItem(key, JSON.stringify(item)) } function getLocalExp(key) { var itemStr = localStorage.getItem(key) // if the item doesn't exist, return null if (!itemStr) { return null } var item = JSON.parse(itemStr) var now = new Date() // compare the expiry time of the item with the current time if (now.getTime() > item.expiry) { // If the item is expired, delete the item from storage // and return null localStorage.removeItem(key) return null } return item.value } var intentStatus = getLocalExp('intent-popup'); if (intentStatus != 'true') { $('.intent-popup').show(); $('.intent-popup__close, .intent-popup__bg').click( function() { $('.intent-popup').hide(); setLocalExp('intent-popup', 'true', 86400000); }); }</script><div class="box1 article article-preview"><div id="subscribeBannerLarge">To read the full article <a href="/user/new">sign up for free</a> or <a href="/user/login">sign in</a>.</div><div class="page-article-teaser__kicker">Endocrine/metabolic</div><h1 class="page-article-teaser__headline"> Epigenetic changes linked to weight regain</h1><div class="page-article-teaser__meta-container"> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 22, 2024</div> <div class="author article-summary__author">By <a href="/authors/2-anette-breindl">Anette Breindl</a></div> <div class="comment-count article-summary__comment-count"><a title=" Epigenetic changes linked to weight regain" class="more" href="https://www.bioworld.com/articles/714726-epigenetic-changes-linked-to-weight-regain#comments-container">No Comments</a></div> </div></div><div class="page-article-teaser__content">Fat cells from patients who had lost weight after bariatric surgery, as well as from animals who had gained and then lost weight, were transcriptionally distinct from cells that had not experienced such weight changes at the organism level. In the animal studies, those transcriptional changes were due to epigenetic changes. The findings, which were published online in <em>Nature</em> on Nov. 18, 2024, are a possible molecular-level explanation for the short-term nature of most weight loss.</div><span class="topics"><a class="topic" href="/topics/85-bioworld-medtech">BioWorld MedTech</a><span class="del"> </span><a class="topic" href="/topics/520-bioworld-science">BioWorld Science</a><span class="del"> </span><a class="topic" href="/topics/246-endocrine-metabolic">Endocrine/metabolic</a></span></div></div><aside class="main-interior-sidebar"><div class="main-interior-sidebar__column"><div id="article-recommendations"></div> </div><div class="main-interior-sidebar__column"><section class="popular-stories "> <h1 class="popular-stories__title">Popular Stories</h1><ul class="popular-stories__items"> <li class="popular-stories__item"> <article class="popular-stories__article popular-stories--article"><div class="popular-stories__details popular-stories__details-1"><h1 class="popular-stories__headline"><a class="popular-stories__article-title-link" href="https://www.bioworld.com/articles/432891-todays-news-in-brief">Today's news in brief</a></h1><div class="popular-stories__topics"><a class="popular-stories__topic-link" href="/topics/84-bioworld">BioWorld</a></div><div class="popular-stories__teaser"><em>BioWorld</em> briefs for Nov. 26, 2024.</div></div></article> </li> <li class="popular-stories__item"> <article class="popular-stories__article popular-stories--article"><div class="popular-stories__details popular-stories__details-1"><h1 class="popular-stories__headline"><a class="popular-stories__article-title-link" href="https://www.bioworld.com/articles/699574-todays-news-in-brief">Today's news in brief</a></h1><div class="popular-stories__topics"><a class="popular-stories__topic-link" href="/topics/85-bioworld-medtech">BioWorld MedTech</a></div><div class="popular-stories__teaser"><em>BioWorld MedTech</em> briefs for November 26, 2024.</div></div></article> </li> <li class="popular-stories__item"> <article class="popular-stories__article -has-image popular-stories--article"><figure class="popular-stories__image"><a class="popular-stories__thumbnail-link" data-eventname="popular-stories" data-eventcategory="click" data-eventaction="popular-stories-image" data-eventlabel="https://www.bioworld.com/articles/714048-j-and-js-ottava-robotic-system-approved-for-us-pivotal-trial" href="https://www.bioworld.com/articles/714048-j-and-js-ottava-robotic-system-approved-for-us-pivotal-trial"><img class="popular-stories__image-thumb" alt="Da Vinci Xi robot - Intuitive Surgical" title="Da Vinci Xi robot - Intuitive Surgical" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BMT-source/2023/1-26--Da-Vinci-Xi-robot-Intuitive-Surgical.png?height=355&t=1699482891&width=640" /></a></figure><div class="popular-stories__details popular-stories__details-1"><h1 class="popular-stories__headline"><a class="popular-stories__article-title-link" href="https://www.bioworld.com/articles/714048-j-and-js-ottava-robotic-system-approved-for-us-pivotal-trial">J&J’s Ottava robotic system approved for US pivotal trial</a></h1><div class="popular-stories__topics"><a class="popular-stories__topic-link" href="/topics/85-bioworld-medtech">BioWorld MedTech</a></div><div class="popular-stories__teaser">Johnson & Johnson received U.S. FDA investigational device exemption to begin the pivotal clinical trial for the Ottava robotic surgical system. 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