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In this investigation, the" /> <title>(PDF) Dentatin from Clausena excavata Induces Apoptosis in HepG2 Cells via Mitochondrial Mediated Signaling | Mohd Sukari - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/24371949/Dentatin_from_Clausena_excavata_induces_apoptosis_and_reduces_the_tumors_size_of_LA_7_induced_mammary_carcinogenesis_in_Sprague_Dawley_rats" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732394804000); window.Aedu.timeDifference = new Date().getTime() - 1732394804000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Hepatocellular carcinoma (HCC) is a primary liver cancer with high global incidence and mortality rates. Current candidate drugs to treat HCC remain lacking and those in use possess undesirable side effects. In this investigation, the antiproliferative effects of dentatin (DTN), a natural coumarin, were evaluated on HepG2 cells and DTN\u0026amp;amp;#39;s probable preliminary molecular mechanisms in apoptosis induction were further investigated. DTN significantly (p\u0026amp;amp;lt;0.05) suppressed proliferation of HepG2 cells with an IC50 value of 12.0 μg/mL, without affecting human normal liver cells, WRL-68 (IC50\u0026amp;amp;gt; 50 μg/mL) causing G0/G1 cell cycle arrest via apoptosis induction. Caspase colorimetric assays showed markedly increased levels of caspase-3 and caspase-9 activities throughout the treatment period. Western blotting of treated HepG2 cells revealed inhibition of NF-κB that triggers the mitochondrial-mediated apoptotic signaling pathway by up-regulating cytoplasmic cytochrome c and Bax, and down...","author":[{"@context":"https://schema.org","@type":"Person","name":"Mohd Sukari"}],"contributor":[],"dateCreated":"2016-12-27","dateModified":"2016-12-27","datePublished":"2015-01-01","headline":"Dentatin from Clausena excavata Induces Apoptosis in HepG2 Cells via Mitochondrial Mediated Signaling","inLanguage":"en","keywords":["Apoptosis","Signal Transduction","Humans","NF-kappa B","Plant Roots","Caspase","Plant extracts","Public health systems and services research","Cell Proliferation"],"locationCreated":null,"publication":"Asian Pacific journal of cancer prevention : APJCP","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/30641150/Dentatin_from_Clausena_excavata_Induces_Apoptosis_in_HepG2_Cells_via_Mitochondrial_Mediated_Signaling","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-352e32ba4e89304dc0b4fa5b3952eef2198174c54cdb79066bc62e91c68a1a91.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" 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[{"id":51085006,"identifier":"Attachment_51085006","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":30641150,"created_at":"2016-12-27T20:49:40.413-08:00","from_world_paper_id":160002440,"updated_at":"2021-01-12T03:38:42.131-08:00","_data":{"abstract":"Hepatocellular carcinoma (HCC) is a primary liver cancer with high global incidence and mortality rates. Current candidate drugs to treat HCC remain lacking and those in use possess undesirable side effects. In this investigation, the antiproliferative effects of dentatin (DTN), a natural coumarin, were evaluated on HepG2 cells and DTN\u0026#39;s probable preliminary molecular mechanisms in apoptosis induction were further investigated. DTN significantly (p\u0026lt;0.05) suppressed proliferation of HepG2 cells with an IC50 value of 12.0 μg/mL, without affecting human normal liver cells, WRL-68 (IC50\u0026gt; 50 μg/mL) causing G0/G1 cell cycle arrest via apoptosis induction. Caspase colorimetric assays showed markedly increased levels of caspase-3 and caspase-9 activities throughout the treatment period. Western blotting of treated HepG2 cells revealed inhibition of NF-κB that triggers the mitochondrial-mediated apoptotic signaling pathway by up-regulating cytoplasmic cytochrome c and Bax, and down...","publication_date":"2015,,","publication_name":"Asian Pacific journal of cancer prevention : APJCP"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Dentatin from Clausena excavata Induces Apoptosis in HepG2 Cells via Mitochondrial Mediated Signaling","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [58370766]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":51085006,"attachmentType":"pdf"}"><img alt="First page of “Dentatin from Clausena excavata Induces Apoptosis in HepG2 Cells via Mitochondrial Mediated Signaling”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/51085006/mini_magick20190126-12599-ttkt0b.png?1548534114" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Dentatin from Clausena excavata Induces Apoptosis in HepG2 Cells via Mitochondrial Mediated Signaling</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="58370766" href="https://independent.academia.edu/MohdSukari"><img alt="Profile image of Mohd Sukari" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Mohd Sukari</a></div><p class="ds-work-card--detail ds2-5-body-sm">2015, Asian Pacific journal of cancer prevention : APJCP</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Hepatocellular carcinoma (HCC) is a primary liver cancer with high global incidence and mortality rates. Current candidate drugs to treat HCC remain lacking and those in use possess undesirable side effects. In this investigation, the antiproliferative effects of dentatin (DTN), a natural coumarin, were evaluated on HepG2 cells and DTN&#39;s probable preliminary molecular mechanisms in apoptosis induction were further investigated. DTN significantly (p&lt;0.05) suppressed proliferation of HepG2 cells with an IC50 value of 12.0 μg/mL, without affecting human normal liver cells, WRL-68 (IC50&gt; 50 μg/mL) causing G0/G1 cell cycle arrest via apoptosis induction. Caspase colorimetric assays showed markedly increased levels of caspase-3 and caspase-9 activities throughout the treatment period. Western blotting of treated HepG2 cells revealed inhibition of NF-κB that triggers the mitochondrial-mediated apoptotic signaling pathway by up-regulating cytoplasmic cytochrome c and Bax, and down...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":51085006,"attachmentType":"pdf","workUrl":"https://www.academia.edu/30641150/Dentatin_from_Clausena_excavata_Induces_Apoptosis_in_HepG2_Cells_via_Mitochondrial_Mediated_Signaling"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":51085006,"attachmentType":"pdf","workUrl":"https://www.academia.edu/30641150/Dentatin_from_Clausena_excavata_Induces_Apoptosis_in_HepG2_Cells_via_Mitochondrial_Mediated_Signaling"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="51085006" data-landing_url="https://www.academia.edu/30641150/Dentatin_from_Clausena_excavata_Induces_Apoptosis_in_HepG2_Cells_via_Mitochondrial_Mediated_Signaling" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="30641173" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30641173/Dentatin_isolated_from_Clausena_excavata_induces_apoptosis_in_MCF_7_cellsthrough_the_intrinsic_pathway_with_involvement_of_NF_kB_signalling_andG0_G1_cell_cycle_arrest_a_bioassay_guided_approach">Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cellsthrough the intrinsic pathway with involvement of NF-kB signalling andG0/G1 cell cycle arrest : a bioassay-guided approach</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58370766" href="https://independent.academia.edu/MohdSukari">Mohd Sukari</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cellsthrough the intrinsic pathway with involvement of NF-kB signalling andG0/G1 cell cycle arrest : a bioassay-guided approach","attachmentId":51085018,"attachmentType":"pdf","work_url":"https://www.academia.edu/30641173/Dentatin_isolated_from_Clausena_excavata_induces_apoptosis_in_MCF_7_cellsthrough_the_intrinsic_pathway_with_involvement_of_NF_kB_signalling_andG0_G1_cell_cycle_arrest_a_bioassay_guided_approach","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/30641173/Dentatin_isolated_from_Clausena_excavata_induces_apoptosis_in_MCF_7_cellsthrough_the_intrinsic_pathway_with_involvement_of_NF_kB_signalling_andG0_G1_cell_cycle_arrest_a_bioassay_guided_approach"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="3642208" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/3642208/Dentatin_Induces_Apoptosis_in_Prostate_Cancer_Cells_via_Bcl_2_Bcl_xL_Survivin_Downregulation_Caspase_9_3_7_Activation_and_NF_%CE%BAB_Inhibition">Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9,-3/7 Activation, and NF-κB Inhibition</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="135439" href="https://malaya.academia.edu/MohdMustafa">Mohd Rais Mustafa</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Evidence-Based Complementary and Alternative Medicine, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">This study was set to investigate antiproliferative potential of dentatin (a natural coumarin isolated from Clausena excavata Burm. F) against prostate cancer and to delineate the underlying mechanism of action. Treatment with dentatin dose-dependently inhibited cell growth of PC-3 and LNCaP prostate cancer cell lines, whereas it showed less cytotoxic effects on normal prostate epithelial cell line (RWPE-1). The inhibitory effect of dentatin on prostate cancer cell growth was due to induction of apoptosis as evidenced by Annexin V staining and cell shrinkage. We found that dentatin-mediated accumulation of reactive oxygen species (ROS) and downregulated expression levels of antiapoptotic molecules (Bcl-2, Bcl-xL, and Survivin), leading to disruption of mitochondrial membrane potential (MMP), cell membrane permeability, and release of cytochrome c from the mitochondria into the cytosol. These effects were associated with induction of caspase-9, -3/7 activities, and subsequent DNA fragmentation. In addition, we found that dentatin inhibited TNF-α-induced nuclear translocation of p65, suggesting dentatin as a potential NF-κB inhibitor. Thus, we suggest that dentatin may have therapeutic value in prostate cancer treatment worthy of further development.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9,-3/7 Activation, and NF-κB Inhibition","attachmentId":31335687,"attachmentType":"pdf","work_url":"https://www.academia.edu/3642208/Dentatin_Induces_Apoptosis_in_Prostate_Cancer_Cells_via_Bcl_2_Bcl_xL_Survivin_Downregulation_Caspase_9_3_7_Activation_and_NF_%CE%BAB_Inhibition","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/3642208/Dentatin_Induces_Apoptosis_in_Prostate_Cancer_Cells_via_Bcl_2_Bcl_xL_Survivin_Downregulation_Caspase_9_3_7_Activation_and_NF_%CE%BAB_Inhibition"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="92525085" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92525085/Characterization_of_dentatin_isolated_from_Clausena_excavate_and_its_potential_use_for_treatment_of_human_breast_and_prostate_cancers">Characterization of dentatin isolated from Clausena excavate and its potential use for treatment of human breast and prostate cancers</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2419442" href="https://independent.academia.edu/IsmaeelArbab">Ismail A D A M Arbab</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2012</p><p class="ds-related-work--abstract ds2-5-body-sm">To date, there has been no literature reported on the mechanism of dentatin and its effects on breast and prostate cancers. Hence, anti-cancer effect of dentatin was investigated towards breast (in vivo and in vitro) and prostate (in vitro) cancers. Ethnopharmacologically, Clausena excavata Burm. F., has been used as folk medicines in the eastern of Thailand for the treatment of cancer. Dentatin (DTN) was isolated from this plant via bio assay guided approach and its apoptosis mechanism was investigated. With respect to MCF-7 cells of breast, DTN induced cytotoxicity was observed using MTT assay. Acridine orange/Propidium iodide staining was used to detect the early apoptosis cells. High content screening (HCS) was used to observe the nuclear condensation,cell permeability, mitochondrial membrane potential (MMP) and cytochrome c release. Apoptosis was confirmed by using clonogenic assay, DNA laddering and caspase 3/7 and 9 assays. Reactive oxygen species formation, Bcl-2/Bax express...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Characterization of dentatin isolated from Clausena excavate and its potential use for treatment of human breast and prostate cancers","attachmentId":95511604,"attachmentType":"pdf","work_url":"https://www.academia.edu/92525085/Characterization_of_dentatin_isolated_from_Clausena_excavate_and_its_potential_use_for_treatment_of_human_breast_and_prostate_cancers","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92525085/Characterization_of_dentatin_isolated_from_Clausena_excavate_and_its_potential_use_for_treatment_of_human_breast_and_prostate_cancers"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="90123195" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90123195/Anticancer_effect_of_dentatin_and_dentatin_hydroxypropyl_%CE%B2_cyclodextrin_complex_on_human_colon_cancer_HT_29_cell_line">Anticancer effect of dentatin and dentatin-hydroxypropyl-β-cyclodextrin complex on human colon cancer (HT-29) cell line</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="243983289" href="https://independent.academia.edu/AhmadAbdul85">Ahmad Abdul</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Drug design, development and therapy, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Dentatin (DEN) (5-methoxy-2, 2-dimethyl-10-(1, 1-dimethyl-2propenyl) dipyran-2-one), a natural compound present in the roots of Clausena excavata Burm f, possesses pro-apoptotic and antiproliferative effects in various cancer cells. Because of its hydrophobicity, it is believed that its complexation with hydroxy-β-cyclodextrin (HPβCD) will make it a potent inhibitor of cancer cell growth. In the current work, the molecular mechanisms of apoptosis induced by DEN and DEN-HPβCD complex were demonstrated in human colon HT-29 cancer cells. After the human colon HT-29 cancer cells were treated with DEN and DEN-HPβCD complex, their effects on the expression of apoptotic-regulated gene markers in mitochondria-mediated apoptotic and death receptor pathways were detected by Western blot analysis and reverse transcription polymerase chain reaction. These markers included caspases-9, 3, and 8, cytochrome c, poly (ADP-ribose) polymerase, p53, p21, cyclin A as well as the Bcl-2 family of proteins...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Anticancer effect of dentatin and dentatin-hydroxypropyl-β-cyclodextrin complex on human colon cancer (HT-29) cell line","attachmentId":93772536,"attachmentType":"pdf","work_url":"https://www.academia.edu/90123195/Anticancer_effect_of_dentatin_and_dentatin_hydroxypropyl_%CE%B2_cyclodextrin_complex_on_human_colon_cancer_HT_29_cell_line","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/90123195/Anticancer_effect_of_dentatin_and_dentatin_hydroxypropyl_%CE%B2_cyclodextrin_complex_on_human_colon_cancer_HT_29_cell_line"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="14396468" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14396468/Dentatin">Dentatin</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="7098926" href="https://putrabusinessschool.academia.edu/HeshuRahman">Heshu S Rahman</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dentatin","attachmentId":38294304,"attachmentType":"pdf","work_url":"https://www.academia.edu/14396468/Dentatin","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14396468/Dentatin"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="47961134" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/47961134/Clausenidin_induces_caspase_dependent_apoptosis_in_colon_cancer">Clausenidin induces caspase-dependent apoptosis in colon cancer</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="188224614" href="https://independent.academia.edu/imaobongetti">imaobong etti</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BMC complementary and alternative medicine, 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">Clausena excavata Burm.f. is a shrub traditionally used to treat cancer patients in Asia. The main bioactive chemical components of the plant are alkaloids and coumarins. In this study, we isolated clausenidin from the roots of C. excavata to determine its apoptotic effect on the colon cancer (HT-29) cell line. We examined the effect of clausenidin on cell viability, ROS generation, DNA fragmentation, mitochondrial membrane potential in HT-29 cells. Ultrastructural analysis was conducted for morphological evidence of apoptosis in the treated HT-29 cells. In addition, we also evaluated the effect of clausenidin treatment on the expression of caspase 3 and 9 genes and proteins in HT-29 cells. Clausenidin induced a G0/G1 cell cycle arrest in HT-29 cells with significant (p &lt; 0.05) dose-dependent increase in apoptotic cell population. The DNA fragmentation assay also showed apoptotic features in the clausenidin-treated HT-29 cells. Clausenidin treatment had caused significant (p &lt;...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Clausenidin induces caspase-dependent apoptosis in colon cancer","attachmentId":66821377,"attachmentType":"pdf","work_url":"https://www.academia.edu/47961134/Clausenidin_induces_caspase_dependent_apoptosis_in_colon_cancer","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/47961134/Clausenidin_induces_caspase_dependent_apoptosis_in_colon_cancer"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="24371949" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24371949/Dentatin_from_Clausena_excavata_induces_apoptosis_and_reduces_the_tumors_size_of_LA_7_induced_mammary_carcinogenesis_in_Sprague_Dawley_rats">Dentatin from Clausena excavata induces apoptosis and reduces the tumors size of LA- 7 induced mammary carcinogenesis in Sprague Dawley rats</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="13425210" href="https://independent.academia.edu/NorrakiahAbdullahSani">Norrakiah Abdullah Sani</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dentatin from Clausena excavata induces apoptosis and reduces the tumors size of LA- 7 induced mammary carcinogenesis in Sprague Dawley rats","attachmentId":44703147,"attachmentType":"pdf","work_url":"https://www.academia.edu/24371949/Dentatin_from_Clausena_excavata_induces_apoptosis_and_reduces_the_tumors_size_of_LA_7_induced_mammary_carcinogenesis_in_Sprague_Dawley_rats","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/24371949/Dentatin_from_Clausena_excavata_induces_apoptosis_and_reduces_the_tumors_size_of_LA_7_induced_mammary_carcinogenesis_in_Sprague_Dawley_rats"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="90123192" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90123192/Inducing_G2_M_Cell_Cycle_Arrest_and_Apoptosis_through_Generation_Reactive_Oxygen_Species_ROS_Mediated_Mitochondria_Pathway_in_HT_29_Cells_by_Dentatin_DEN_and_Dentatin_Incorporated_in_Hydroxypropyl_%CE%B2_Cyclodextrin_DEN_HP%CE%B2CD_">Inducing G2/M Cell Cycle Arrest and Apoptosis through Generation Reactive Oxygen Species (ROS)-Mediated Mitochondria Pathway in HT-29 Cells by Dentatin (DEN) and Dentatin Incorporated in Hydroxypropyl-β-Cyclodextrin (DEN-HPβCD)</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="243983289" href="https://independent.academia.edu/AhmadAbdul85">Ahmad Abdul</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Molecular Sciences, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Inducing G2/M Cell Cycle Arrest and Apoptosis through Generation Reactive Oxygen Species (ROS)-Mediated Mitochondria Pathway in HT-29 Cells by Dentatin (DEN) and Dentatin Incorporated in Hydroxypropyl-β-Cyclodextrin (DEN-HPβCD)","attachmentId":93772479,"attachmentType":"pdf","work_url":"https://www.academia.edu/90123192/Inducing_G2_M_Cell_Cycle_Arrest_and_Apoptosis_through_Generation_Reactive_Oxygen_Species_ROS_Mediated_Mitochondria_Pathway_in_HT_29_Cells_by_Dentatin_DEN_and_Dentatin_Incorporated_in_Hydroxypropyl_%CE%B2_Cyclodextrin_DEN_HP%CE%B2CD_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/90123192/Inducing_G2_M_Cell_Cycle_Arrest_and_Apoptosis_through_Generation_Reactive_Oxygen_Species_ROS_Mediated_Mitochondria_Pathway_in_HT_29_Cells_by_Dentatin_DEN_and_Dentatin_Incorporated_in_Hydroxypropyl_%CE%B2_Cyclodextrin_DEN_HP%CE%B2CD_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="105160342" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/105160342/Clausenidin_Induces_Caspase_8_Dependent_Apoptosis_and_Suppresses_Production_of_VEGF_in_Liver_Cancer_Cells">Clausenidin Induces Caspase 8-Dependent Apoptosis and Suppresses Production of VEGF in Liver Cancer Cells</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="30245646" href="https://independent.academia.edu/PeterWaziri">Peter Waziri</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Asian Pacific journal of cancer prevention : APJCP, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Clausena excavata Burm f. is used by traditional healers to treat cancer patients in South East Asia. The use of the plant and its compounds is based on Asian folklore with little or no scientific evidence supporting the therapeutic efficacy The current study aimed to determine the effect of pure clausenidin isolated from C. excavata on caspase-8-induced cell death as well as angiogenesis in the HepG2 hepatocellular carcinoma cell line. Caspase-8 and extrinsic death receptor protein expression was determined using spectrophotometry and protein profile arrays, respectively. Ultrastructural analysis of clausenidin-treated cells was conducted using transmission electron microscopy. In addition, anti-angiogenic effects of clausenidin were investigated by Western blot analysis. Clausenidin significantly (p&lt;0.05) increased the activity of caspase-8 and expression of protein components of the death inducing signaling complex (DISC) in HepG2 cells. Ultrastructural analysis of the clausen...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Clausenidin Induces Caspase 8-Dependent Apoptosis and Suppresses Production of VEGF in Liver Cancer Cells","attachmentId":104690018,"attachmentType":"pdf","work_url":"https://www.academia.edu/105160342/Clausenidin_Induces_Caspase_8_Dependent_Apoptosis_and_Suppresses_Production_of_VEGF_in_Liver_Cancer_Cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/105160342/Clausenidin_Induces_Caspase_8_Dependent_Apoptosis_and_Suppresses_Production_of_VEGF_in_Liver_Cancer_Cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="20644651" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/20644651/Hederagenin_from_the_leaves_of_ivy_Hedera_helix_L_induces_apoptosis_in_human_LoVo_colon_cells_through_the_mitochondrial_pathway">Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41963665" href="https://independent.academia.edu/YunLi22">Yun Li</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BMC Complementary and Alternative Medicine, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway","attachmentId":41482329,"attachmentType":"pdf","work_url":"https://www.academia.edu/20644651/Hederagenin_from_the_leaves_of_ivy_Hedera_helix_L_induces_apoptosis_in_human_LoVo_colon_cells_through_the_mitochondrial_pathway","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/20644651/Hederagenin_from_the_leaves_of_ivy_Hedera_helix_L_induces_apoptosis_in_human_LoVo_colon_cells_through_the_mitochondrial_pathway"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":51085006,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":51085006,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_51085006" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="49854775" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/49854775/Cytotoxicity_and_Apoptosis_Induction_of_Coumarins_and_Carbazole_Alkaloids_from_Clausena_Harmandiana">Cytotoxicity and Apoptosis Induction of Coumarins and Carbazole Alkaloids from Clausena Harmandiana</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="181630633" href="https://kku.academia.edu/NatthidaWeerapreeyakul">Natthida Weerapreeyakul</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecules</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cytotoxicity and Apoptosis Induction of Coumarins and Carbazole Alkaloids from Clausena Harmandiana","attachmentId":68058986,"attachmentType":"pdf","work_url":"https://www.academia.edu/49854775/Cytotoxicity_and_Apoptosis_Induction_of_Coumarins_and_Carbazole_Alkaloids_from_Clausena_Harmandiana","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/49854775/Cytotoxicity_and_Apoptosis_Induction_of_Coumarins_and_Carbazole_Alkaloids_from_Clausena_Harmandiana"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="48458823" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/48458823/_content_ROS_Mediated_Mitochondrial_Pathway_is_Required_for_L_P_Royen_Leaf_Methanol_Extract_Inducing_Apoptosis_in_the_Modulation_of_Caspase_Activation_and_EGFR_NF_B_Activities_of_HeLa_Human_Cervical_Cancer_Cells_i_content_Manilkara_Zapota_content_%CE%BA_">{"__content__"=>"ROS-Mediated Mitochondrial Pathway is Required for (L.) 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Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-B Activities of HeLa Human Cervical Cancer Cells.\", \"i\"=\u003e[{\"__content__\"=\u003e\"Manilkara Zapota\"}, {\"__content__\"=\u003e\"κ\"}]}","attachmentId":67059368,"attachmentType":"pdf","work_url":"https://www.academia.edu/48458823/_content_ROS_Mediated_Mitochondrial_Pathway_is_Required_for_L_P_Royen_Leaf_Methanol_Extract_Inducing_Apoptosis_in_the_Modulation_of_Caspase_Activation_and_EGFR_NF_B_Activities_of_HeLa_Human_Cervical_Cancer_Cells_i_content_Manilkara_Zapota_content_%CE%BA_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/48458823/_content_ROS_Mediated_Mitochondrial_Pathway_is_Required_for_L_P_Royen_Leaf_Methanol_Extract_Inducing_Apoptosis_in_the_Modulation_of_Caspase_Activation_and_EGFR_NF_B_Activities_of_HeLa_Human_Cervical_Cancer_Cells_i_content_Manilkara_Zapota_content_%CE%BA_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="23163346" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23163346/Natural_Plant_Extract_Tubeimoside_I_Promotes_Apoptosis_Mediated_Cell_Death_in_Cultured_Human_Hepatoma_HepG2_Cells">Natural Plant Extract Tubeimoside I Promotes Apoptosis-Mediated Cell Death in Cultured Human Hepatoma (HepG2) Cells</a><div 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