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<div> <div data-drupal-messages-fallback class="hidden"></div> </div> </div> </div> </div> <div id="main-content" class="main-content"> <div class="main-content__content"> <div id="block-arrive-content"> <article class="page"> <div class="container"> <div class="row"> <div class="col-md-12"> <h1><span>ARRIVE study plan</span> </h1> </div> </div> </div> <div class="page__components components"> <div class="components__component"> <div class="container"> <div class="row"> <div class="col-md-12"> <div class="text-editor"> <p class="large" style="line-height:150%;margin:0cm;vertical-align:baseline;">The ARRIVE study plan is a tool for researchers, technicians and ethical review bodies, offering a structured template to promote transparent communication of planned <em>in vivo</em> studies. </p> <p class="large" style="line-height:150%;margin:0cm;vertical-align:baseline;"> </p> <p style="line-height:21.0pt;margin-bottom:15.0pt;margin-left:0cm;margin-right:0cm;margin-top:0cm;vertical-align:baseline;">Designed to support good experimental practices from the outset, the ARRIVE study plan ensures that each animal research experiment is considered carefully. By documenting the procedural plans and experimental design (e.g. minimising bias, selecting appropriate sample sizes and employing suitable statistical analyses) in a clear and standardised format, the template facilitates a thorough review of a prospective study by animal care staff and ethical review committees. This enables an assessment of the rigour of the research, the refinement of the procedures and the likelihood of discovering reliable findings.</p> </div> </div> </div> </div> </div> <div class="components__component"> <div class="downloads"> <div class="container"> <div class="row"> <div class="col-md-12"> <div> <div><article class="test document"> <div class="document__icon"> <img src="/themes/custom/arrive/images/icons/file.png" alt=""> </div> <div class="document__content"> <div class="document__link"> <a href="https://arriveguidelines.org/sites/arrive/files/documents/ARRIVE%20study%20plan_0.docx">ARRIVE study plan</a> </div> <div class="document__description">Free to use download of the ARRIVE study plan. The document can be used as it is, or the information incorporated into an establishment's own processes.</div> <div class="document__info"><span class="document__size">158.31 KB</span> docx </div> </div> </article> </div> </div> </div> </div> </div> </div> </div> <div class="components__component"> <div class="container"> <div class="row"> <div class="col-md-12"> <div class="text-editor"> <p style="line-height:21.0pt;margin:0cm;vertical-align:baseline;">The ARRIVE study plan fosters collaboration between researchers and animal units by clearly communicating the planned procedures and rigour strategies to be used. This approach sets a consistent practice that all parties can follow, helps to ensure compliance with relevant training and project records, and contributes to the successful conduct of <em>in vivo</em> research.</p> <p style="line-height:21.0pt;margin:0cm;vertical-align:baseline;"> </p> <p style="line-height:21.0pt;margin:0cm;vertical-align:baseline;">We strongly recommend using the NC3Rs <a href="https://eda.nc3rs.org.uk/"><strong>Experimental Design Assistant</strong></a> (EDA) alongside the ARRIVE study plan. The EDA offers tailored advice on study design and analysis, and its workflow diagram can be integrated into the study plan, providing a visual representation of the planned <em>in vivo</em> experiment. This integration further enhances transparency and aids in the effective communication of the study's design.</p> <p style="line-height:21.0pt;margin:0cm;vertical-align:baseline;"> </p> <p style="line-height:21.0pt;margin:0cm;vertical-align:baseline;">Before embarking on research involving the use of animals it is also critical to form a clear hypothesis, identify possible non-animal alternatives to all or part of the proposed study and assess the relevance of the chosen model to answer the experimental question. We encourage researchers to consult the <a href="https://gbr01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fnorecopa.no%2Fprepare&data=05%7C02%7CStephen.Turnock%40nc3rs.org.uk%7C49731b53fc464f28e48e08dcf7569ba0%7C8bb7e08edaa44a8e927efca38db04b7e%7C0%7C0%7C638657198554716842%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=Vd8V%2Fo9Vcl4b5%2BFtIQVsRWFLTqMmJciaUtqB26qnxTg%3D&reserved=0"><strong>PREPARE guidelines</strong></a> before considering the use of animals in research. PREPARE provides researchers with an extensive overview to formulating an experiment and the requirements of using animals before carrying out the research.</p> <p style="line-height:21.0pt;margin:0cm;vertical-align:baseline;"><span style="color:#555555;"> </span></p> </div> </div> </div> </div> </div> <div class="components__component"> <div class="text_image_50_50 text_image_50_50--after-title"> <div class="container"> <div class="row"> <div class="col-md-6 text_image_50_50__text"> <div><h3>Why use the ARRIVE study plan?</h3> <p class="large">For technicians and animal units</p> <ul> <li> <p style="margin:0cm;vertical-align:baseline;">Provides documentation for record keeping and monitoring compliance.</p> </li> <li> <p style="margin-bottom:0cm;margin-right:0cm;margin-top:0cm;tab-stops:list 36.0pt;vertical-align:baseline;">Includes all procedural and welfare details.</p> </li> <li> <p style="margin-bottom:0cm;margin-right:0cm;margin-top:0cm;tab-stops:list 36.0pt;vertical-align:baseline;">Identify opportunities to support rigorous science.</p> </li> </ul> <p class="large">For researchers</p> <ul> <li> <p style="margin:0cm;vertical-align:baseline;">Links and guidance on experimental design support.</p> </li> <li> <p style="margin-bottom:0cm;margin-right:0cm;margin-top:0cm;tab-stops:list 36.0pt;vertical-align:baseline;">Promotes the use of rigorous, unbiased experimental methods.</p> </li> <li> <p style="margin-bottom:0cm;margin-right:0cm;margin-top:0cm;tab-stops:list 36.0pt;vertical-align:baseline;">Provides a record for full and transparent reporting of <em>in vivo</em> studies.</p> </li> </ul> <p class="large">For ethical review bodies</p> <ul> <li> <p style="margin:0cm;vertical-align:baseline;">Maximises the use of existing infrastructure for greater 3Rs impact.</p> </li> <li> <p style="margin-bottom:0cm;margin-right:0cm;margin-top:0cm;tab-stops:list 36.0pt;vertical-align:baseline;">Assists in the harm-benefit analysis during ethical review.</p> </li> <li> <p style="margin-bottom:0cm;margin-right:0cm;margin-top:0cm;tab-stops:list 36.0pt;vertical-align:baseline;">Promotes best practice in the conduct of animal research.</p> </li> </ul> </div> </div> <div class="col-md-6 text_image_50_50__image"> <div> <img src="/sites/arrive/files/2024-10/Picture%20for%20website_s_2.png" width="2329" height="2356" alt="Picture showing the ARRIVE study plan. The "Experimental Animals" section is shown with an arrow pointing to text hyperlinked to experimental design resources and an arrow pointing to indicate that sections are expandable to add more rows. The "Section 2" of the ARRIVE study plan is shown with an arrow indicating that section two focuses on the experimental rigour and an arrow showing that short guidance is written in the document. " loading="lazy" /> </div> </div> </div> </div> </div> </div> <div class="components__component"> <div class="container"> <div class="row"> <div class="col-md-12"> <div class="text-editor"> <p><em>If you require an accessible format ARRIVE study plan, please email </em><a href="mailto:arrive@nc3rs.org.uk"><em>arrive@nc3rs.org.uk</em></a>.</p> </div> </div> </div> </div> </div> <div class="components__component"> <div class="container"> <div class="row"> <div class="col-md-12"> <div class="card card--full-width"> <div class="card__image"> <div> <img src="/sites/arrive/files/2024-10/EDA%20website%20crop_1.png" width="1280" height="720" alt="Screengrab of the Experimental Design Assistant website" loading="lazy" /> </div> </div> <div class="card__content"> <div><a href="https://eda.nc3rs.org.uk/" target="parent" class="card__link" rel="noopener noreferrer"><span class="card__title">Experimental Design Assistant</span></a></div> <div class="card__description"><p>The NC3Rs developed the Experimental Design Assistant (EDA), a free-to-use online tool, to help design robust experiments more likely to yield reliable and reproducible results. </p> <p>The EDA helps you build a diagram representing your experimental plan, which can be critiqued by the system to provide bespoke experimental design feedback. 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