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Saturday, November 23, 2024</div></section><div id="section-2" class="main-body"> <script src="/javascripts/pages/article.js"></script> <div id="breadcrumbs" class="breadcrumbs"><a class="" href="/">Home</a> » <a class="" href="/topics">Topics</a> » Conferences</div> <div class="box1 article-topic"> <div class="records"> <h1 class="page-title"> Conferences <div class="rss"> <a href="/rss/topic/154-conferences"> <img alt="Conferences RSS Feed" height="16" width="16" loading="lazy" src="/images/icons/rss.gif" /> RSS </a> </div> </h1> <article class="record article-summary "> <div class="image"><a title="LBL-042, a bispecific antibody targeting PD-1 and LILRB1/2 that can overcome resistance to PD-1 monotherapy" class="url" rel="" target="" href="https://www.bioworld.com/articles/714602-lbl-042-a-bispecific-antibody-targeting-pd-1-and-lilrb1-2-that-can-overcome-resistance-to-pd-1-monotherapy"><img width="650" height="488" alt="3d rendering of bispecific antibodies" title="3d rendering of bispecific antibodies" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Drugs/3D-bispecific-antibodies.jpg?height=488&t=1732120101&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Immuno-oncology</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714602-lbl-042-a-bispecific-antibody-targeting-pd-1-and-lilrb1-2-that-can-overcome-resistance-to-pd-1-monotherapy">LBL-042, a bispecific antibody targeting PD-1 and LILRB1/2 that can overcome resistance to PD-1 monotherapy</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 20, 2024</div> <div class="comment-count article-summary__comment-count"><a title="LBL-042, a bispecific antibody targeting PD-1 and LILRB1/2 that can overcome resistance to PD-1 monotherapy" class="more" href="https://www.bioworld.com/articles/714602-lbl-042-a-bispecific-antibody-targeting-pd-1-and-lilrb1-2-that-can-overcome-resistance-to-pd-1-monotherapy#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">A team from Nanjing Leads Biolabs Co. Ltd. presented the discovery and preclinical characterization of LBL-042, a novel bispecific antibody designed to simultaneously target PD-1 and LILRB1/2, with the aim of improving immune evasion of tumor microenvironment and potentially overcoming resistance to immuno-oncology therapy.<br /></div><a title="LBL-042, a bispecific antibody targeting PD-1 and LILRB1/2 that can overcome resistance to PD-1 monotherapy" class="more" href="https://www.bioworld.com/articles/714602-lbl-042-a-bispecific-antibody-targeting-pd-1-and-lilrb1-2-that-can-overcome-resistance-to-pd-1-monotherapy">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <div class="kicker article-summary__kicker">Cancer</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714604-gsc-000829-a-selective-fgfr2-fgfr3-inhibitor-for-cancer-therapy">GSC-000829, a selective FGFR2/FGFR3 inhibitor, for cancer therapy</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 20, 2024</div> <div class="comment-count article-summary__comment-count"><a title="GSC-000829, a selective FGFR2/FGFR3 inhibitor, for cancer therapy" class="more" href="https://www.bioworld.com/articles/714604-gsc-000829-a-selective-fgfr2-fgfr3-inhibitor-for-cancer-therapy#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Changchun Genescience Pharmaceuticals Co. Ltd. has reported GSC-000829, a novel and selective FGFR2/FGFR3 inhibitor being developed for the potential treatment of cancer.<br /></div><a title="GSC-000829, a selective FGFR2/FGFR3 inhibitor, for cancer therapy" class="more" href="https://www.bioworld.com/articles/714604-gsc-000829-a-selective-fgfr2-fgfr3-inhibitor-for-cancer-therapy">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="FAP inhibitor AZD-2389 improves liver fibrosis and MASH" class="url" rel="" target="" href="https://www.bioworld.com/articles/714598-fap-inhibitor-azd-2389-improves-liver-fibrosis-and-mash"><img width="650" height="488" alt="Photomicrograph of liver biopsy in a patient with cirrhosis, showing bridging septal fibrosis and regenerative nodules. " title="Photomicrograph of liver biopsy in a patient with cirrhosis. " border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/liver-cirrhosis-fibrosis.jpg?height=488&t=1712672928&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Gastrointestinal</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714598-fap-inhibitor-azd-2389-improves-liver-fibrosis-and-mash">FAP inhibitor AZD-2389 improves liver fibrosis and MASH</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 20, 2024</div> <div class="comment-count article-summary__comment-count"><a title="FAP inhibitor AZD-2389 improves liver fibrosis and MASH" class="more" href="https://www.bioworld.com/articles/714598-fap-inhibitor-azd-2389-improves-liver-fibrosis-and-mash#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Astrazeneca plc has developed a potent oral fibroblast activation protein (FAP) inhibitor, AZD-2389, that avoids the cleavage of FGF21 and α2-AP. AZD-2389 was tested in cynomolgus monkeys with diet-induced MASH.<br /></div><a title="FAP inhibitor AZD-2389 improves liver fibrosis and MASH" class="more" href="https://www.bioworld.com/articles/714598-fap-inhibitor-azd-2389-improves-liver-fibrosis-and-mash">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <div class="kicker article-summary__kicker">Cancer</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714597-dan-222-demonstrates-efficacy-in-pediatric-solid-tumor-models">DAN-222 demonstrates efficacy in pediatric solid tumor models</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 20, 2024</div> <div class="comment-count article-summary__comment-count"><a title="DAN-222 demonstrates efficacy in pediatric solid tumor models" class="more" href="https://www.bioworld.com/articles/714597-dan-222-demonstrates-efficacy-in-pediatric-solid-tumor-models#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">DAN-222 is a polymeric nanoparticle covalently conjugated with the topoisomerase I inhibitor camptothecin, which has previously demonstrated promising clinical activity in heavily pretreated patients with breast cancer (NCT05261269).<br /></div><a title="DAN-222 demonstrates efficacy in pediatric solid tumor models" class="more" href="https://www.bioworld.com/articles/714597-dan-222-demonstrates-efficacy-in-pediatric-solid-tumor-models">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="EDG-7500 reverses nonobstructive hypertrophic cardiomyopathy in vivo " class="url" rel="" target="" href="https://www.bioworld.com/articles/714596-edg-7500-reverses-nonobstructive-hypertrophic-cardiomyopathy-in-vivo"><img width="650" height="488" alt="Illustration of human heart with DNA structure background" title="Illustration of human heart with DNA structure background" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cardiovascular/heart-DNA-gene-therapy.png?height=488&t=1721919232&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Cardiovascular</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714596-edg-7500-reverses-nonobstructive-hypertrophic-cardiomyopathy-in-vivo">EDG-7500 reverses nonobstructive hypertrophic cardiomyopathy in vivo </a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 20, 2024</div> <div class="comment-count article-summary__comment-count"><a title="EDG-7500 reverses nonobstructive hypertrophic cardiomyopathy in vivo " class="more" href="https://www.bioworld.com/articles/714596-edg-7500-reverses-nonobstructive-hypertrophic-cardiomyopathy-in-vivo#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disorder with around 85% of people with HCM remaining undiagnosed. There are no treatments approved for nonobstructive HCM (nHCM) to date.<br /></div><a title="EDG-7500 reverses nonobstructive hypertrophic cardiomyopathy in vivo " class="more" href="https://www.bioworld.com/articles/714596-edg-7500-reverses-nonobstructive-hypertrophic-cardiomyopathy-in-vivo">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="The Liver Meeting: A mashup of MASH data" class="url" rel="" target="" href="https://www.bioworld.com/articles/714647-the-liver-meeting-a-mashup-of-mash-data"><img width="650" height="488" alt="Liver " title="Liver " border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Liver-7-7.png?height=488&t=1657229334&width=650" /></a></div> <div class="article-summary__details has-image"> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714647-the-liver-meeting-a-mashup-of-mash-data">The Liver Meeting: A mashup of MASH data</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 19, 2024</div> <div class="author article-summary__author">By <a href="/authors/29-brian-orelli">Brian Orelli</a></div> <div class="comment-count article-summary__comment-count"><a title="The Liver Meeting: A mashup of MASH data" class="more" href="https://www.bioworld.com/articles/714647-the-liver-meeting-a-mashup-of-mash-data#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Advertisements for Rezdiffra (resmetirom, Madrigal Pharmaceuticals Inc.), which was approved by the U.S. FDA in March 2024, adorned the lobby of The Liver Meeting 2024 being held at the San Diego Convention Center as well as the trolley stop across the street and other areas that doctors attending the meeting might be swayed. But inside the ballrooms of the convention center, companies were making presentations of data from clinical trials testing their drugs in patients with metabolic dysfunction-associated steatohepatitis (MASH) in hopes of potentially competing with Rezdiffra in a few years.<br /></div><a title="The Liver Meeting: A mashup of MASH data" class="more" href="https://www.bioworld.com/articles/714647-the-liver-meeting-a-mashup-of-mash-data">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Synrx Therapeutics reports new PARG inhibitor" class="url" rel="" target="" href="https://www.bioworld.com/articles/714575-synrx-therapeutics-reports-new-parg-inhibitor"><img width="650" height="488" alt="Scientist looking in microscope, chemical structure concept image" title="Scientist looking in microscope, chemical structure concept image" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Science-researcher-structures-atoms-micoroscope.jpg?height=488&t=1692196171&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Cancer</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714575-synrx-therapeutics-reports-new-parg-inhibitor">Synrx Therapeutics reports new PARG inhibitor</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 19, 2024</div> <div class="comment-count article-summary__comment-count"><a title="Synrx Therapeutics reports new PARG inhibitor" class="more" href="https://www.bioworld.com/articles/714575-synrx-therapeutics-reports-new-parg-inhibitor#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Hangzhou Synrx Therapeutics Biomedical Technology Co. Ltd. recently presented the development and characterization of a novel PARG inhibitor, SYN-608, for the potential treatment of tumors with/without homologous recombination deﬁciency (HRD).<br /></div><a title="Synrx Therapeutics reports new PARG inhibitor" class="more" href="https://www.bioworld.com/articles/714575-synrx-therapeutics-reports-new-parg-inhibitor">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <div class="kicker article-summary__kicker">Cancer</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714574-xpr1-unveiled-as-therapeutic-target-in-lung-cancer">XPR1 unveiled as therapeutic target in lung cancer</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 19, 2024</div> <div class="comment-count article-summary__comment-count"><a title="XPR1 unveiled as therapeutic target in lung cancer" class="more" href="https://www.bioworld.com/articles/714574-xpr1-unveiled-as-therapeutic-target-in-lung-cancer#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Tumor cell survival is dependent on phosphate homeostasis, which requires high amounts of energy. Researchers have demonstrated that the silencing of xenotropic and polytropic retrovirus receptor 1 (XPR1) led to reduced tumor growth in an ovarian cancer cell line xenograft, and similar vulnerability was found in lung cancer.<br /></div><a title="XPR1 unveiled as therapeutic target in lung cancer" class="more" href="https://www.bioworld.com/articles/714574-xpr1-unveiled-as-therapeutic-target-in-lung-cancer">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="MT-303 exerts antitumoral activity in liver cancer" class="url" rel="" target="" href="https://www.bioworld.com/articles/714573-mt-303-exerts-antitumoral-activity-in-liver-cancer"><img width="650" height="488" alt="Photomicrograph of hepatocellular carcinoma" title="Photomicrograph of hepatocellular carcinoma" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/Cancer-hepatocellular-carcinoma-HCC-liver.png?height=488&t=1666018535&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Cancer</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714573-mt-303-exerts-antitumoral-activity-in-liver-cancer">MT-303 exerts antitumoral activity in liver cancer</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 19, 2024</div> <div class="comment-count article-summary__comment-count"><a title="MT-303 exerts antitumoral activity in liver cancer" class="more" href="https://www.bioworld.com/articles/714573-mt-303-exerts-antitumoral-activity-in-liver-cancer#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Hepatocellular carcinoma (HCC) is the most common type of liver cancer, with a 5-year survival rate of 18%. Glypican-3 (GPC3) is a protein with high expression in HCC but not in healthy tissue, making it an interesting target for therapy.<br /></div><a title="MT-303 exerts antitumoral activity in liver cancer" class="more" href="https://www.bioworld.com/articles/714573-mt-303-exerts-antitumoral-activity-in-liver-cancer">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="BB-201, a potent first-in-class anti-Her2/anti-Trop2 bispecific ADC candidate" class="url" rel="" target="" href="https://www.bioworld.com/articles/714572-bb-201-a-potent-first-in-class-anti-her2-anti-trop2-bispecific-adc-candidate"><img width="650" height="488" alt="Lab glassware and antibodies art concept" title="Lab glassware and antibodies art concept" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Immune/antibodies-lab-research.jpg?height=488&t=1717686528&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Cancer</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714572-bb-201-a-potent-first-in-class-anti-her2-anti-trop2-bispecific-adc-candidate">BB-201, a potent first-in-class anti-Her2/anti-Trop2 bispecific ADC candidate</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 19, 2024</div> <div class="comment-count article-summary__comment-count"><a title="BB-201, a potent first-in-class anti-Her2/anti-Trop2 bispecific ADC candidate" class="more" href="https://www.bioworld.com/articles/714572-bb-201-a-potent-first-in-class-anti-her2-anti-trop2-bispecific-adc-candidate#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Researchers from Bright Biologics LLC presented the discovery and preclinical characterization of a novel bispecific anti-Her2/anti-Trop2 antibody-drug conjugate (ADC), BB-201.<br /></div><a title="BB-201, a potent first-in-class anti-Her2/anti-Trop2 bispecific ADC candidate" class="more" href="https://www.bioworld.com/articles/714572-bb-201-a-potent-first-in-class-anti-her2-anti-trop2-bispecific-adc-candidate">Read More</a> </div> </article> </div> <div class="pager"> <div role="navigation" aria-label="Pagination" class="pagination"><a class="previous_page" rel="prev" href="/articles/topic/154-conferences?page=1">Previous</a> <a rel="prev" aria-label="Page 1" href="/articles/topic/154-conferences?page=1">1</a> <em class="current" aria-label="Page 2" aria-current="page">2</em> <a rel="next" aria-label="Page 3" href="/articles/topic/154-conferences?page=3">3</a> <a aria-label="Page 4" href="/articles/topic/154-conferences?page=4">4</a> <a aria-label="Page 5" href="/articles/topic/154-conferences?page=5">5</a> <a aria-label="Page 6" href="/articles/topic/154-conferences?page=6">6</a> <a aria-label="Page 7" href="/articles/topic/154-conferences?page=7">7</a> <a 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