CINXE.COM

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block-system clearfix"><div class="content"><div id="node-136069" class="node node-product-sub-category page-node- node-type-product-category" about="/all-about-probes" typeof="sioc:Item foaf:Document"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs" id="myTab"><li class="active pro-category-136069"><a href="/all-about-probes" class="active">All About Probes</a></li><li class="pro-category-136071" ><a href="/catalog-probes">Catalog Probes</a></li><li class="pro-category-20223" ><a href="/newprobes">New Probe Request</a></li></ul></div><div class="tab-content"><div id="tab0" class="tab-pane fade in active profile"><div class="sample-image"><div class="profile-content"><h3>RNAscope™, BaseScope™ and miRNAscope™ Probes</h3></div><div class="profile-content"> <article class="read-more"><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><div class="about-probes-wrap"><div class="about-probes"><p>The RNAscope and BaseScope Assays are based on the proprietary RNAscope Technology enabling RNA target expression analysis within intact cells and tissues with high sensitivity and specificity. Learn more about the difference between <a href="https://acdbio.com/rnascope%C2%AE-and-basescope%E2%84%A2-assays">RNAscope, BaseScope and miRNAscope Assays</a>.</p></div><div class="about-blocks"><div class="title">Catalog and Made-to-Order Probes</div><p>Using proprietary ACD RNAscope Probe Design Pipeline, we provide double "Z" oligo probes designed to hybridize to your specific RNA target of interest. We can design <em>in situ</em> hybridization RNA probes for virtually ANY gene in ANY genome for visualization in ANY tissue or Cells.</p><div class="sec-title">Catalog Target Probes</div><p>Previously designed and used by our customers, they can be shipped to you in approx. 2 weeks. Our catalog probes span over 40,000 RNA targets in over 400 species including human, mouse, rat, dog, cow, zebrafish, rabbit, pig, chicken, monkeys and over 100 viruses. Search and select from our over ever-growing catalog of<em> in situ</em> hybridization probe sets.</p><div class="sec-title">RNAscope Made-to-Order Target Probes</div><p>New probes for your gene of interest will be designed and manufactured in about 2 weeks.</p><div class="sec-title">Probe Exclusivity</div><p>Under certain conditions, ACD may agree to grant exclusivity to probes against "proprietary and private" targets for a fee. While ACD still owns the probe design for these targets, we are committed to not market these probes until the probe exclusivity is removed. Please talk to your account executive for further information.</p></div><div class="about-blocks"><div class="title">Probe Name Nomenclature</div><div class="show-hide"><div class="r-show"><div class="sub-title">RNAscope Probe Name Nomenclature</div></div><div class="r-hide"><div class="flexible_content nomenclature"><div class="nomen-tabs"><ul><li key="probe-type">Probe<br /><div class="arrow_box"> </div><div class="text">Probe Type</div></li><li key="species">Hs<br /><div class="arrow_box"> </div><div class="text">Species</div></li><li key="gene">FDXR<br /><div class="arrow_box"> </div><div class="text">Gene</div></li><li key="specification">5UTR<br /><div class="arrow_box"> </div><div class="text">Specification</div></li><li key="spectral-channel">C2<br /><div class="arrow_box"> </div><div class="text">Amplification Channel</div></li></ul></div><div class="nomen-content" style="display: none;"><div id="probe-type"><p><b>These are three types of RNAscope probes. The type of probe is indicated as follows:</b></p><p><b><u>Probe</u></b><br />for Manual Assays</p><p><b><u>LS Probe</u></b><br />for Leica Systems automated assays</p><p><b><u>VS Probe</u></b><br />for Ventana Systems automated assays</p></div><div id="species"><p>Species refers to the probe target species and implies that the probe is designed to the gene of the specified species. The species is typically identified by two letter designations such as "Hs" for Homo Sapiens, "Mm" for Mus musculus etc</p></div><div id="gene"><p>This refers to the Official Gene Symbol as listed in the NCBI Database</p></div><div class="active" id="specification"><p>This indicates any specific target region within the gene</p></div><div id="spectral-channel"><p>This indicates the probe amplification channel denoted by C1, C2 or C3. RNAscope probes default to Channel 1 unless specified. This channel indicates the compatibility of the probes with different amplification systems and indicate which detection kits the probes would be compatible with.</p><p>C1 probes are compatible with all detection platforms</p><p>C2 probes are compatible only with the 2.5 HD Duplex Detection Kit and the Fluorescent Detection Kit</p><p>C3 channel probes are only compatible with the Fluorescent Detection Kit</p></div></div><div class="cntent"><div class="sec-title">Example 1</div><div class="sub-title">LS Probe - Mm-Rspo3</div><div class="desp"><p>This probe used in <b>Leica Automated System Assay</b>(LS Probe) and is designed to hybridize to <b>Mus musculus</b> (Mm) <b>Rspo3</b> gene. Its spectral channel is not listed which means Spectral Channel 1 and therefore compatible with any of the four manual assays including RNAscope 2.5 HD Reagent Kit-BROWN, RNAscope 2.5 HD Reagent Kit-RED, RNAscope 2.5 HD Duplex Reagent Kit or RNAscope Multiplex Fluorescent Reagent Kit.</p></div></div><div class="cntent"><div class="sec-title">Example 2</div><div class="sub-title">Probe-Hs-GNRHR-5UTR-C2</div><div class="desp"><p>This is probe is designed to be used with a <b>manual assay</b> (Probe). It targets just the <b>5' untranslated region</b> (5UTR) of the <b>GNRHR</b> gene from the human sequence(Hs). This probe is compatible with <b>spectral channel 2</b> (C2), so it can be used in a duplex or multiplex assay.</p></div></div></div></div></div><p> </p><div class="show-hide"><div class="r-show"><div class="sub-title">BaseScope Probe Name Nomenclature</div></div><div class="r-hide"><div class="flexible_content nomenclature"><div class="nomen-tabs"><ul><li key="probe-type">BA<br /><div class="arrow_box"> </div><div class="text">Platform</div></li><li key="species">Mm<br /><div class="arrow_box"> </div><div class="text">Species</div></li><li key="gene">Nrg1<br /><div class="arrow_box"> </div><div class="text">Gene</div></li><li key="specification">E1E2<br /><div class="arrow_box"> </div><div class="text">Sub-Type</div></li></ul></div><div class="nomen-content" style="display: none;"><div id="probe-type"><p>The BaseScope™ Assay is a recent addition to the RNAscope™ Technology product portfolio, launched in early 2016. Using the same innovative technology and proprietary probe design as used in the RNAscope Assay, the BaseScope Assay is further refined to detect as few as 1-4 Z pairs.</p></div><div id="species"><p>Species refers to the probe target species and implies that the probe is designed to the gene of the specified species. The species is typically identified by two letter designations such as "Hs" for Homo Sapiens, "Mm" for Mus musculus etc</p></div><div id="gene"><p>This refers to the Official Gene Symbol as listed in the NCBI Database</p></div><div id="specification"><p>BaseScope technology enables the specific detection of mutations, exon junctions, short target sequences, highly homologous sequences, circular RNA and fusion genes with single molecule detection sensitivity in a broad range of tissues, samples and species. These sub-type helps classify probes for the intended applications.</p><p>As an example in this probe E1E2 designates that this probe spans across junction of Exon 1 and 2 of the NRG1 Gene</p></div></div><div class="cntent"><div class="sec-title">Example</div><div class="sub-title">BaseScope Probe - BA-Dm-Gapdh1-3zz</div><div class="desp"><p>This probe is compatible with Manual BaseScope assays and is designed to hybridize to <em>Drosophila melanogaster</em> Gapdh1 gene. The 3ZZ specifies the number of probe pairs and indicates this is a short target probe.</p></div></div></div></div></div></div><div class="about-blocks full-width"><div class="title">Probe Compatibility</div><div class="classification full"><div class="tablefield-wrapper" id="tablefield-wrapper-0"><p> </p><table class="tablefield sticky-enabled tableheader-processed sticky-table" id="tablefield-0"><thead><tr><th class="row_0 col_0" scope="col"><p>Probes<br />Assay Compatibility</p></th><th class="row_0 col_1" scope="col"><p>RNAscope Manual Assays</p></th><th class="row_0 col_2" scope="col"><p>RNAscope 2.5 LS (Leica Biosystems)</p></th><th class="row_0 col_3" scope="col"><p>RNAscope 2.5 VS (Roche Tissue Diagnostics Systems)</p></th><th class="row_0 col_3" scope="col"><p>BaseScope Manual Assay</p></th><th class="row_0 col_3" scope="col"><p>BaseScope LS (Leica Biosystems)</p></th><th class="row_0 col_3" scope="col"><p>BaseScope VS (<span style="font-weight: 700; text-align: center;">Roche Tissue Diagnostics</span><span style="font-weight: 700; text-align: center;"> Systems</span>)</p></th><th class="row_0 col_3" scope="col"><p>miRNAscope Manual Assay</p></th><th class="row_0 col_3" scope="col"><p>miRNAscope LS (Leica Biosystems)</p></th></tr></thead><tbody><tr class="even"><td class="row_2 col_0"><p>Probe Name & Naming convention</p></td><td class="row_2 col_1"><p>Diaminobenzidine<br />(DAB)RNAscope Probe<br />Eg: Probe - Hs-FDXR-C2</p></td><td class="row_2 col_2"><p>2.5 LS RNAscope Probe<br />Eg: 2.5 LS Probe - Hs-FDXR</p></td><td class="row_2 col_3"><p>2.5 VS RNAscope Probe<br />Eg: 2.5 VS Probe - Hs-FDXR</p></td><td class="row_2 col_3"><p>BaseScope Probe<br />Eg: BA-Mm-Hdgfrp3-E3E4</p></td><td class="row_2 col_3"><p>BaseScope LS Probe<br />Eg: LS Probe BA-Mm-Hdgfrp3-E3E4</p></td><td class="row_2 col_3"><p>BaseScope VS Probe<br />Eg: VS Probe BA-Mm-Hdgfrp3-E3E4</p></td><td class="row_2 col_3"><p>miRNAscope Probe<br />Eg: SR-Mmu-miR-122-5p-S1</p></td><td class="row_2 col_3"><p>miRNAscope LS Probe<br />Eg: LS Probe SR-Mmu-miR-122-5p-S1</p></td></tr><tr class="odd"><td class="row_3 col_0"><p>Probe naming convention</p></td><td class="row_3 col_1"><p>Probe Type-Species-Gene Name-Channel</p></td><td class="row_3 col_2"><p>Probe Type-Species-Gene Name</p></td><td class="row_3 col_3"><p>Probe Type-Species-Gene Name</p></td><td class="row_3 col_3"><p>Platform-Species-Gene-Sub-Type</p></td><td class="row_2 col_3"><p>Platform-Species-Gene-Sub-Type</p></td><td class="row_2 col_3"><p>Platform-Species-Gene-Sub-Type</p></td><td class="row_2 col_3"><p>Platform-Species Type-Gene-Strand-Amplification Channel</p></td><td class="row_2 col_3"><p>Platform-Species Type-Gene-Strand-Amplification Channel</p></td></tr><tr class="even"><td class="row_4 col_0"><p>Spectral Channel Compatibility</p></td><td class="row_4 col_1"><p>Available for Channel 1-4<br />(C1, C2,C3, & C4)<br />T1-T12 (T1, T2, T3, T4, T5, T6, T7, T8, T9. T10, T11, T12)<br />When Channel No. is missing, the probe is a C1 probe</p></td><td class="row_4 col_2"><p>Available for Channel 1-4<br />(C1, C2,C3, & C4)<br />When Channel No. is missing, the probe is a C1 probe</p></td><td class="row_4 col_3"><p>Available for Channel 1 and 2 Only.<br />When Channel No. is missing, the probe is a C1 probe.</p></td><td class="row_4 col_3"><p>Channel 1 and 2 Only. When Channel No. is missing, the probe is a C1 probe.</p></td><td class="row_2 col_3"><p>Channel 1 Only. When Channel No. is missing, the probe is a C1 probe.</p></td><td class="row_2 col_3"><p>Channel 1 Only. When Channel No. is missing, the probe is a C1 probe.</p></td><td class="row_2 col_3"><p>Channel S1 Only.</p></td><td class="row_2 col_3"><p>Channel S1 Only.</p></td></tr><tr class="odd"><td class="row_5 col_0"><p>C1 Probes Assay Compatibility</p></td><td class="row_5 col_1"><p>C1 is spectral channel 1 and is the most abundant probe type.<br />RNAscope 2.5 HD Reagent Kit--BROWN</p><p>RNAscope 2.5 HD Reagent Kit--RED</p><p>RNAscope 2.5 HD Duplex Reagent Kit</p><p>RNAscope Fluorescent Multiplex Reagent Kit</p><p>RNAscope Multiplex Fluorescent Reagent Kit v2</p><p>RNAscope HiPlex12 Reagents Kit (488, 550, 647)</p><p>RNAscope HiPlex12 Reagents Kit (488, 550, 647, 750)</p></td><td class="row_5 col_2"><p>RNAscope 2.5 LS Assay Reagent Kit--BROWN</p><p>RNAscope 2.5 LS Assay Reagent Kit--RED</p><p>RNAscope 2.5 LS Duplex Reagent Kit</p><p>RNAscope LS Multiplex Fluorescent Reagent Kit</p></td><td class="row_5 col_3"><p>RNAscope VS Universal HRP Reagent Kit</p><p>RNAscope VS Universal AP Reagent Kit</p><p>RNAscope VS Duplex Reagent Kit</p></td><td class="row_5 col_3"><p>BaseScope Reagent Kit v2–RED</p><p>BaseScope Duplex Reagent Kit</p></td><td class="row_2 col_3"><p>BaseScope LS Reagent Kit</p></td><td class="row_2 col_3"><p>BaseScope VS Reagent Kit</p></td><td class="row_2 col_3"><p>Channel S1 miRNAscope HD Reagent Kit - RED</p></td><td class="row_2 col_3"><p>Channel S1 miRNAscope LS Reagent Kit - RED</p></td></tr><tr class="even"><td class="row_6 col_0"><p>C2 Probes Assay Compatibility</p></td><td class="row_6 col_1"><p>C2 is spectral channel 2<br />RNAscope 2.5 HD Duplex Reagent Kit</p><p>RNAscope Fluorescent Multiplex Reagent Kit</p><p>RNAscope Multiplex Fluorescent Reagent Kit v2</p></td><td class="row_6 col_2"><p>RNAscope 2.5 LS Duplex Reagent Kit</p><p>RNAscope LS Multiplex Fluorescent Reagent Kit</p></td><td class="row_6 col_3"><p>RNAscope VS Duplex Reagent Kit</p></td><td class="row_6 col_3"><p>BaseScope Duplex Reagent Kit</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td></tr><tr class="odd"><td class="row_7 col_0"><p>C3 Probes Assay Compatibility</p></td><td class="row_7 col_1"><p>C3 is spectral channel 3<br />RNAscope Fluorescent Multiplex Reagent Kit</p><p>RNAscope Multiplex Fluorescent Reagent Kit v2</p></td><td class="row_7 col_2"><p>RNAscope LS Multiplex Fluorescent Reagent Kit</p></td><td class="row_7 col_3"><p>Not Available</p></td><td class="row_7 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td></tr><tr class="odd"><td class="row_7 col_0"><p>C4 Probes Assay Compatibility</p></td><td class="row_7 col_1"><p>C4 is spectral channel 4<br />RNAscope 4-Plex Ancillary Kit for Multiplex Fluorescent Kit v2</p></td><td class="row_7 col_2"><p>RNAscope LS 4-Plex Ancillary Kit for LS Multiplex Fluorescent</p></td><td class="row_7 col_3"><p>Not Available</p></td><td class="row_7 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td></tr><tr class="even"><td class="row_8 col_0"><p>T1-T12 Probes Assay Compatibility</p></td><td class="row_8 col_1"><p>HiPlex12 Reagents Kit (488, 550, 647)<br />RNAscope HiPlex12 Reagents Kit (488, 550, 647, 750)</p></td><td class="row_8 col_2"><p>Not Available</p></td><td class="row_8 col_3"><p>Not Available</p></td><td class="row_8 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td><td class="row_2 col_3"><p>Not Available</p></td></tr><tr class="odd"><td class="row_8 col_0"><p>Probe Volume</p></td><td class="row_8 col_1"><p>Probes for 20 slides (C1-C4)<br />Probes for 10 slides (T1-T12)</p></td><td class="row_8 col_2"><p>Probes for 30 slides</p></td><td class="row_8 col_3"><p>Probes for 30 slides</p></td><td class="row_8 col_3"><p>Probes for 20 slides</p></td><td class="row_2 col_3"><p>Probes for 30 slides</p></td><td class="row_2 col_3"><p>Probes for 30 slides</p></td><td class="row_2 col_3"><p>Probes for 20 slides</p></td><td class="row_2 col_3"><p>Probes for 30 slides</p></td></tr><tr class="even"><td class="row_9 col_0"><p>Species Designation Probe name contains two letters to indicate species name</p></td><td class="row_9 col_1"><p>Hs-<em>Homo Sapien</em><br />Mm-<em>Mus musculus</em><br />Rt-<em>Rattus norvegicus</em><br />ACD offers >40 species</p></td><td class="row_9 col_2"><p>Hs-<em>Homo Sapien</em><br />Mm-<em>Mus musculus</em><br />Rt-<em>Rattus norvegicus</em><br />ACD offers >40 species</p></td><td class="row_9 col_3"><p>Hs-<em>Homo Sapien</em><br />Mm-<em>Mus musculus</em><br />Rt-<em>Rattus norvegicus</em><br />ACD offers >40 species</p></td><td class="row_9 col_3"><p>Hs-<em>Homo Sapien</em><br />Mm-<em>Mus musculus</em><br />Rt-<em>Rattus norvegicus</em><br />ACD offers >40 species</p></td><td class="row_2 col_3"><p>Hs-<em>Homo Sapien</em><br />Mm-<em>Mus musculus</em><br />Rt-<em>Rattus norvegicus</em><br />ACD offers >40 species</p></td><td class="row_2 col_3"><p>Hs-<em>Homo Sapien</em><br />Mm-<em>Mus musculus</em><br />Rt-<em>Rattus norvegicus</em><br />ACD offers >40 species</p></td><td class="row_2 col_3"><p>Hsa-<em>Homo Sapien</em><br />Mm-<em>Mus musculus</em><br />Rno-<em>Rattus norvegicus</em><br />ACD offers >40 species</p></td><td class="row_2 col_3"><p>Hsa-<em>Homo Sapien</em><br />Mm-<em>Mus musculus</em><br />Rno-<em>Rattus norvegicus</em><br />ACD offers >40 species</p></td></tr></tbody></table></div></div></div></div></div></div></div> </article></div><div 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more details in the Contact Sales form below</p></div><div class="needhelp-tab"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs" id="help-tictab"><li class="active"><a data-toggle="tab" href="#contactsales">Contact Sales</a></li><li><a data-toggle="tab" href="#contactsupport">Contact Support</a></li><li><a data-toggle="tab" href="#contactpharma">Contact Services</a></li><li><a data-toggle="tab" href="#contactinfo">Offices</a></li></ul></div><div class="tab-content"><div class="needhelp-tab-container tab-pane fade in active" id="contactsales"><div class="supportform-con"><div class="contact-tab-form supportform-con"> <script src="//info.bio-techne.com/js/forms2/js/forms2.min.js"></script> <form id="mktoForm_9816"></form> <script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9816);</script> </div></div></div><div class="needhelp-tab-container tab-pane fade" id="contactsupport"><div class="supportform-con"><form action="https://proteinsimple--obtfull.my.salesforce.com/servlet/servlet.WebToCase?encoding=UTF-8" id="web-to-case1" method="POST"><div class="row"><div class="col-md-6"> <label for="fname">First Name</label> <input id="fname" maxlength="80" name="fname" size="20" type="text"></div><div class="col-md-6"> <label for="lname">Last Name</label> <input id="lname" maxlength="80" name="lname" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="email">Email</label> <input id="email" maxlength="80" name="email" size="20" type="text"></div><div class="col-md-6"> <label for="phone">Phone</label> <input id="phone" maxlength="40" name="phone" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="company">Institution / Company</label> <input id="company" maxlength="80" name="company" size="20" type="text"></div></div><div class="row"><div class="col-md-12"> <label for="description">Message</label> <textarea name="description"></textarea> </div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <label>Type the characters that you see in the picture below</label> <input type="text" id="PageCaseCaptcha" disabled /> <a class="btnrefresh" onclick="DrawCaptcha();"></a></div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <input type="text" class="case_captcha" id="PageCaseInput" name="case_captcha"/><div id="pagecasecaptcha-error"></div></div></div> <input type="submit" name="submit" style="float:left;" onclick="ValidCaptcha('pagecase');"><div class="clear"></div></form></div></div><div class="needhelp-tab-container tab-pane fade" id="contactinfo"><div class="supportform-con contact-info"><div class="row"><h3>Advanced Cell Diagnostics</h3><p>Our new headquarters office starting May 2016:</p><p>7707 Gateway Blvd. <br />Newark, CA 94560<br />Toll Free: 1 (877) 576-3636<br />Phone: (510) 576-8800<br />Fax: (510) 576-8798</p></div><div class="row"><p> </p><div class="row"><h3>Bio-Techne</h3><p>19 Barton Lane <br />Abingdon Science Park<br />Abingdon<br />OX14 3NB<br />United Kingdom<br />Phone 2: +44 1235 529449<br />Fax: +44 1235 533420</p><p> </p></div><div class="row"><h3>Advanced Cell Diagnostics China</h3><p>20F, Tower 3,<br />Raffles City Changning Office,<br />1193 Changning Road, Shanghai 200051</p><p>021-52293200<br /><a href="mailto:info.cn@bio-techne.com">info.cn@bio-techne.com</a><br />Web: <a href="http://www.acdbio.com/cn">www.acdbio.com/cn</a></p></div><div class="row"><p>For general information: <a href="mailto:Info.ACD@bio-techne.com">Info.ACD@bio-techne.com</a><br />For place an order: <a href="mailto:order.ACD@bio-techne.com">order.ACD@bio-techne.com</a><br />For product support: <a href="mailto:support.ACD@bio-techne.com">support.ACD@bio-techne.com</a><br />For career opportunities: <a href="mailto:hr.ACD@bio-techne.com">hr.ACD@bio-techne.com</a></p></div></div><div class="row" style="border-bottom: none;"><div class="col-md-6"> <a href="/about/distributors" class="meet-out-sales-team" title="See Distributors">See Distributors</a></div></div></div></div><div class="needhelp-tab-container tab-pane fade" id="contactpharma"><div class="supportform-con"><div class="contact-tab-form supportform-con"><form id="mktoForm_9817"></form> <script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9817);</script> </div></div></div></div></div></div></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { $("#web-to-case1").validate({ // Specify the validation rules rules: { fname: "required", lname: "required", phone:"required", email: { required: true, email: true }, company: "required", case_captcha: "required" }, // Specify the validation error messages messages: { fname: "Please enter your First Name", lname: "Please enter your Last Name", email: "Please enter your email address", phone: "Please enter your 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