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combination</title> <meta name="description" content="Search results for: drug combination"> <meta name="keywords" content="drug combination"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="drug combination"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 4942</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: drug combination</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4942</span> Development and in vitro Evaluation of Polymer-Drug Conjugates Containing Potentiating Agents for Combination Therapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Blessing%20A.%20Aderibigbe">Blessing A. Aderibigbe</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Combination therapy is a treatment approach that is used to prevent the emergence of drug resistance. This approach is used for the treatment of many chronic and infectious diseases. Potentiating agents are currently explored in combination therapy, resulting in excellent therapeutic outcomes. Breast cancer and malaria are two chronic conditions responsible globally for high death rates. In this research, a class of polymer-drug conjugates containing potentiating agents with either antimalarial or anticancer drugs were prepared by Michael Addition Polymerization reaction and ring-opening polymerization reaction. Conjugation of potentiating agents with bioactive compounds into the polymers resulted in conjugates with good water solubility, highly selective and non-toxic. In vitro cytotoxicity and in vitro antiplasmodial evaluation on the conjugates revealed that the conjugates were more effective when compared to the free drugs. The drug release studies further showed that the release profile of the drugs from the conjugates was sustained. The findings revealed the potential of polymer-drug conjugates to overcome drug toxicity and drug resistance, which is common with the currently used antimalarial and anticancer drugs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anticancer" title="anticancer">anticancer</a>, <a href="https://publications.waset.org/abstracts/search?q=antimalarials" title=" antimalarials"> antimalarials</a>, <a href="https://publications.waset.org/abstracts/search?q=combination%20therapy" title=" combination therapy"> combination therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=polymer-drug%20conjugates" title=" polymer-drug conjugates"> polymer-drug conjugates</a> </p> <a href="https://publications.waset.org/abstracts/111039/development-and-in-vitro-evaluation-of-polymer-drug-conjugates-containing-potentiating-agents-for-combination-therapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/111039.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">133</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4941</span> Formulation and Evaluation of Curcumin-Zn (II) Microparticulate Drug Delivery System for Antimalarial Activity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20R.%20Aher">M. R. Aher</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20B.%20Laware"> R. B. Laware</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20S.%20%20Asane"> G. S. Asane</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20S.%20Kuchekar"> B. S. Kuchekar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: Studies have shown that a new combination therapy with Artemisinin derivatives and curcumin is unique, with potential advantages over known ACTs. In present study an attempt was made to prepare microparticulate drug delivery system of Curcumin-Zn complex and evaluate it in combination with artemether for antimalarial activity. Material and method: Curcumin Zn complex was prepared and encapsulated using sodium alginate. Microparticles thus obtained are further coated with various enteric polymers at different coating thickness to control the release. Microparticles are evaluated for encapsulation efficiency, drug loading and in vitro drug release. Roentgenographic Studies was conducted in rabbits with BaSO 4 tagged formulation. Optimized formulation was screened for antimalarial activity using P. berghei-infected mice survival test and % paracetemia inhibition, alone (three oral dose of 5mg/day) and in combination with arthemether (i.p. 500, 1000 and 1500µg). Curcumin-Zn(II) was estimated in serum after oral administration to rats by using spectroflurometry. Result: Microparticles coated with Cellulose acetate phthalate showed most satisfactory and controlled release with 479 min time for 60% drug release. X-ray images taken at different time intervals confirmed the retention of formulation in GI tract. Estimation of curcumin in serum by spectroflurometry showed that drug concentration is maintained in the blood for longer time with tmax of 6 hours. The survival time (40 days post treatment) of mice infected with P. berghei was compared to survival after treatment with either Curcumin-Zn(II) microparticles artemether combination, curcumin-Zn complex and artemether. Oral administration of Curcumin-Zn(II)-artemether prolonged the survival of P.berghei-infected mice. All the mice treated with Curcumin-Zn(II) microparticles (5mg/day) artemether (1000µg) survived for more than 40 days and recovered with no detectable parasitemia. Administration of Curcumin-Zn(II) artemether combination reduced the parasitemia in mice by more than 90% compared to that in control mice for the first 3 days after treatment. Conclusion: Antimalarial activity of the curcumin Zn-artemether combination was more pronounced than mono therapy. A single dose of 1000µg of artemether in curcumin-Zn combination gives complete protection in P. berghei-infected mice. This may reduce the chances of drug resistance in malaria management. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=formulation" title="formulation">formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=microparticulate%20drug%20delivery" title=" microparticulate drug delivery"> microparticulate drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=antimalarial" title=" antimalarial"> antimalarial</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmaceutics" title=" pharmaceutics"> pharmaceutics</a> </p> <a href="https://publications.waset.org/abstracts/26467/formulation-and-evaluation-of-curcumin-zn-ii-microparticulate-drug-delivery-system-for-antimalarial-activity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26467.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">394</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4940</span> Antihyperlipidemia Combination of Simvastatin and Herbal Drink (Conventional Drug Interaction Potential Study and Herbal As Prevention Adverse Effect on Combination Therapy Hyperlipidemia) </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gesti%20Prastiti">Gesti Prastiti</a>, <a href="https://publications.waset.org/abstracts/search?q=Maylina%20Adani"> Maylina Adani</a>, <a href="https://publications.waset.org/abstracts/search?q=Yuyun%20darma%20A.%20N."> Yuyun darma A. N.</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Khilmi%20F."> M. Khilmi F.</a>, <a href="https://publications.waset.org/abstracts/search?q=Yunita%20Wahyu%20Pratiwi"> Yunita Wahyu Pratiwi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Combination therapy may allow interaction on two drugs or more that can give adverse effects on patients. Simvastatin is a drug of antihyperlipidemia it can interact with drugs which work on cytochrome P450 CYP3A4 because it can interfere the performance of simvastatin. Flavonoid found in plants can inhibit the cytochrome P450 CYP3A4 if taken with simvastatin and can increase simvastatin levels in the body and increases the potential side effects of simvastatin such as myopati and rhabdomyolysis. Green tea leaves and mint are herbal medicine which has the effect of antihiperlipidemia. This study aims to determine the potential interaction of simvastatin with herbal drinks (green tea leaves and mint). This research method are experimental post-test only control design. Test subjects were divided into 5 groups: normal group, negative control group, simvastatin group, a combination of green tea group and the combination group mint leaves. The study was conducted over 32 days and total cholesterol levels were analyzed by enzymatic colorimetric test method. Results of this study is the obtainment of average value of total cholesterol in each group, the normal group (65.92 mg/dL), the negative control group the average total cholesterol test in the normal group was (69.86 mg/dL), simvastatin group (58.96 mg/dL), the combination of green tea group (58.96 mg/dL), and the combination of mint leaves (63.68 mg/dL). The conclusion is between simvastatin combination therapy with herbal drinks have the potential for pharmacodynamic interactions with a synergistic effect, antagonist, and a powerful additive, so the combination therapy are no more effective than a single administration of simvastatin therapy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hyperlipidemia" title="hyperlipidemia">hyperlipidemia</a>, <a href="https://publications.waset.org/abstracts/search?q=simvastatin" title=" simvastatin"> simvastatin</a>, <a href="https://publications.waset.org/abstracts/search?q=herbal%20drinks" title=" herbal drinks"> herbal drinks</a>, <a href="https://publications.waset.org/abstracts/search?q=green%20tea%20leaves" title=" green tea leaves"> green tea leaves</a>, <a href="https://publications.waset.org/abstracts/search?q=mint%20leaves" title=" mint leaves"> mint leaves</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20interactions" title=" drug interactions"> drug interactions</a> </p> <a href="https://publications.waset.org/abstracts/32521/antihyperlipidemia-combination-of-simvastatin-and-herbal-drink-conventional-drug-interaction-potential-study-and-herbal-as-prevention-adverse-effect-on-combination-therapy-hyperlipidemia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32521.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">395</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4939</span> Genetics of Pharmacokinetic Drug-Drug Interactions of Most Commonly Used Drug Combinations in the UK: Uncovering Unrecognised Associations</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mustafa%20Malki">Mustafa Malki</a>, <a href="https://publications.waset.org/abstracts/search?q=Ewan%20R.%20Pearson"> Ewan R. Pearson</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tools utilized by health care practitioners to flag potential adverse drug reactions secondary to drug-drug interactions ignore individual genetic variation, which has the potential to markedly alter the severity of these interactions. To our best knowledge, there have been limited published studies on the impact of genetic variation on drug-drug interactions. Therefore, our aim in this project is the discovery of previously unrecognized, clinically important drug-drug-gene interactions (DDGIs) within the list of most commonly used drug combinations in the UK. The UKBB database was utilized to identify the top most frequently prescribed drug combinations in the UK with at least one route of interaction (over than 200 combinations were identified). We have recognised 37 common and unique interacting genes considering all of our drug combinations. Out of around 600 potential genetic variants found in these 37 genes, 100 variants have met the selection criteria (common variant with minor allele frequency ≥ 5%, independence, and has passed HWE test). The association between these variants and the use of each of our top drug combinations has been tested with a case-control analysis under the log-additive model. As the data is cross-sectional, drug intolerance has been identified from the genotype distribution as presented by the lower percentage of patients carrying the risky allele and on the drug combination compared to those free of these risk factors and vice versa with drug tolerance. In GoDARTs database, the same list of common drug combinations identified by the UKBB was utilized here with the same list of candidate genetic variants but with the addition of 14 new SNPs so that we have a total of 114 variants which have met the selection criteria in GoDARTs. From the list of the top 200 drug combinations, we have selected 28 combinations where the two drugs in each combination are known to be used chronically. For each of our 28 combinations, three drug response phenotypes have been identified (drug stop/switch, dose decrease, or dose increase of any of the two drugs during their interaction). The association between each of the three phenotypes belonging to each of our 28 drug combinations has been tested against our 114 candidate genetic variants. The results show replication of four findings between both databases : (1) Omeprazole +Amitriptyline +rs2246709 (A > G) variant in CYP3A4 gene (p-values and ORs with the UKBB and GoDARTs respectively = 0.048,0.037,0.92,and 0.52 (dose increase phenotype)) (2) Simvastatin + Ranitidine + rs9332197 (T > C) variant in CYP2C9 gene (0.024,0.032,0.81, and 5.75 (drug stop/switch phenotype)) (3) Atorvastatin + Doxazosin + rs9282564 (T > C) variant in ABCB1 gene (0.0015,0.0095,1.58,and 3.14 (drug stop/switch phenotype)) (4) Simvastatin + Nifedipine + rs2257401 (C > G) variant in CYP3A7 gene (0.025,0.019,0.77,and 0.30 (drug stop/switch phenotype)). In addition, some other non-replicated, but interesting, significant findings were detected. Our work also provides a great source of information for researchers interested in DD, DG, or DDG interactions studies as it has highlighted the top common drug combinations in the UK with recognizing 114 significant genetic variants related to drugs' pharmacokinetic. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adverse%20drug%20reactions" title="adverse drug reactions">adverse drug reactions</a>, <a href="https://publications.waset.org/abstracts/search?q=common%20drug%20combinations" title=" common drug combinations"> common drug combinations</a>, <a href="https://publications.waset.org/abstracts/search?q=drug-drug-gene%20interactions" title=" drug-drug-gene interactions"> drug-drug-gene interactions</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmacogenomics" title=" pharmacogenomics"> pharmacogenomics</a> </p> <a href="https://publications.waset.org/abstracts/101278/genetics-of-pharmacokinetic-drug-drug-interactions-of-most-commonly-used-drug-combinations-in-the-uk-uncovering-unrecognised-associations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/101278.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">163</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4938</span> Simultaneous Determination of Proposed Anti-HIV Combination Comprising of Elvitegravir and Quercetin in Rat Plasma Using the HPLC–ESI-MS/MS Method: Drug Interaction Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lubna%20Azmi">Lubna Azmi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ila%20Shukla"> Ila Shukla</a>, <a href="https://publications.waset.org/abstracts/search?q=Shyam%20Sundar%20Gupta"> Shyam Sundar Gupta</a>, <a href="https://publications.waset.org/abstracts/search?q=Padam%20Kant"> Padam Kant</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20V.%20Rao"> C. V. Rao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Elvitegravir is the mainstay of anti-HIV combination therapy in most endemic countries presently. However, it cannot be used alone owing to its long onset time of action. 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one (Quercetin: QU) is a polyphenolic compound obtained from Argeria speciosa Linn (Family: Convolvulaceae), an anti-HIV candidate. In the present study, a sensitive, simple and rapid high-performance liquid chromatography coupled with positive ion electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method was developed for the simultaneous determination elvitegravir and Quercetin, in rat plasma. The method was linear over a range of 0.2–500 ng/ml. All validation parameters met the acceptance criteria according to regulatory guidelines. LC–MS/MS method for determination of Elvitegravir and Quercetin was developed and validated. Results show the potential of drug–drug interaction upon co-administration this marketed drugs and plant derived secondary metabolite. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anti-HIV%20resistance" title="anti-HIV resistance">anti-HIV resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=extraction" title=" extraction"> extraction</a>, <a href="https://publications.waset.org/abstracts/search?q=HPLC-ESI-MS-MS" title=" HPLC-ESI-MS-MS"> HPLC-ESI-MS-MS</a>, <a href="https://publications.waset.org/abstracts/search?q=validation" title=" validation"> validation</a> </p> <a href="https://publications.waset.org/abstracts/63318/simultaneous-determination-of-proposed-anti-hiv-combination-comprising-of-elvitegravir-and-quercetin-in-rat-plasma-using-the-hplc-esi-msms-method-drug-interaction-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63318.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">344</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4937</span> Release of Calcein from Liposomes Using Low and High Frequency Ultrasound</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ghaleb%20A.%20Husseini">Ghaleb A. Husseini</a>, <a href="https://publications.waset.org/abstracts/search?q=Salma%20E.%20Ahmed"> Salma E. Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Hesham%20G.%20Moussa"> Hesham G. Moussa</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20M.%20Martins"> Ana M. Martins</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Al-Sayah"> Mohammad Al-Sayah</a>, <a href="https://publications.waset.org/abstracts/search?q=Nasser%20Qaddoumi"> Nasser Qaddoumi </a> </p> <p class="card-text"><strong>Abstract:</strong></p> This abstract aims to investigate the use of targeted liposomes as anticancer drug carriers in vitro in combination with ultrasound applied as drug trigger; in order to reduce the side effects caused by traditional chemotherapy. Pegylated liposomes were used to encapsulate calcein and then release this model drug when 20-kHz, 40-kHz, 1-MHz and 3-MHz ultrasound were applied at different acoustic power densities. Fluorescence techniques were then used to measure the percent drug release of calcein from these targeted liposomes. Results showed that as the power density increases, at the four frequencies studied, the release of calcein also increased. Based on these results, we believe that ultrasound can be used to increase the rate and amount of chemotherapeutics release from liposomes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=liposomes" title="liposomes">liposomes</a>, <a href="https://publications.waset.org/abstracts/search?q=calcein%20release" title=" calcein release"> calcein release</a>, <a href="https://publications.waset.org/abstracts/search?q=high%20frequency%20ultrasound" title=" high frequency ultrasound"> high frequency ultrasound</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20frequency%20ultrasound" title=" low frequency ultrasound"> low frequency ultrasound</a>, <a href="https://publications.waset.org/abstracts/search?q=fluorescence%20techniques" title=" fluorescence techniques"> fluorescence techniques</a> </p> <a href="https://publications.waset.org/abstracts/24679/release-of-calcein-from-liposomes-using-low-and-high-frequency-ultrasound" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24679.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">424</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4936</span> Modulated Bioavailability of an Anti HIV Drug through a Self-Nanoemulsifying Drug Delivery System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sunit%20Kumar%20Sahoo">Sunit Kumar Sahoo</a>, <a href="https://publications.waset.org/abstracts/search?q=Prakash%20Chandra%20Senapati"> Prakash Chandra Senapati</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The main drawback to design drug delivery systems with BCS class II drugs is their low bioavailabilty due to their inherent low permeability characteristics. So the present investigation aspire to develop a self-nanoemulsifying drug delivery system (SNEDDS) of BCS class II anti HIV drug efavirenz (EFZ) using mixtures of non-ionic surfactant mixtures with the main objective to improve the oral bioavailability of said drug. Results obtained from solubility studies of EFZ in various expients utilized for construction of the pseudo ternary phase diagram containing surfactant mixtures. Surfactants in 1:1 combination are used with different co-surfactants in different ratio to delineate the area of monophasic region of the pseudo ternary phase diagram. The formulations which offered positive results in different thermodynamic stability studies were considered for percentage transmittance and turbidity analysis. The various characterization studies like the TEM analysis of post diluted SNEDDS formulations r confirmed the size in nanometric range (below 50 nm) and FT-IR studies confirmed the intactness of the drug the in the preconcentrate. The in vitro dissolution profile of SNEDDS showed that 80% drug was released within 30 min in case of optimized SNEDDS while it was approximately 18.3 % in the case of plain drug powder.. The Pharmacokinetic study using rat model revealed a 2.63 fold increase in AUC (0-∞) in comparison to plain EFZ suspension. The designed delivery system illustrated the confidence in creating a formulation of EFZ with enhanced bioavailability for better HIV treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=efavirenz" title="efavirenz">efavirenz</a>, <a href="https://publications.waset.org/abstracts/search?q=self-nanoemulsifying" title=" self-nanoemulsifying"> self-nanoemulsifying</a>, <a href="https://publications.waset.org/abstracts/search?q=surfactant%20mixture" title=" surfactant mixture"> surfactant mixture</a>, <a href="https://publications.waset.org/abstracts/search?q=bioavailability" title=" bioavailability"> bioavailability</a> </p> <a href="https://publications.waset.org/abstracts/39271/modulated-bioavailability-of-an-anti-hiv-drug-through-a-self-nanoemulsifying-drug-delivery-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39271.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">354</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4935</span> Solubility Enhancement of Poorly Soluble Anticancer Drug, Docetaxel Using a Novel Polymer, Soluplus via Solid Dispersion Technique</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adinarayana%20Gorajana">Adinarayana Gorajana</a>, <a href="https://publications.waset.org/abstracts/search?q=Venkata%20Srikanth%20Meka"> Venkata Srikanth Meka</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjay%20Garg"> Sanjay Garg</a>, <a href="https://publications.waset.org/abstracts/search?q=Lim%20Sue%20May"> Lim Sue May</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study was designed to evaluate and enhance the solubility of poorly soluble drug, docetaxel through solid dispersion (SD) technique prepared using freeze drying method. Docetaxel solid dispersions were formulated with Soluplus in different weight ratios. Freeze drying method was used to prepare the solid dispersions. Solubility of the solid dispersions were evaluated respectively and the optimized of drug-solubilizers ratio systems were characterized with different analytical methods like Differential scanning calorimeter (DSC), Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) to confirm the formation of complexes between drug and solubilizers. The solubility data revealed an overall improvement in solubility for all SD formulations. The ternary combination 1:5:2 gave the highest increase in solubility that is approximately 3 folds from the pure drug, suggesting the optimum drug-solubilizers ratio system. This data corresponds with the DSC and SEM analyses, which demonstrates presence of drug in amorphous state and the dispersion in the solubilizers in molecular level. The solubility of the poorly soluble drug, docetaxel was enhanced through preparation of solid dispersion formulations employing freeze drying method. Solid dispersion with multiple carrier system shows better solubility compared to single carrier system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=docetaxel" title="docetaxel">docetaxel</a>, <a href="https://publications.waset.org/abstracts/search?q=freeze%20drying" title=" freeze drying"> freeze drying</a>, <a href="https://publications.waset.org/abstracts/search?q=soluplus" title=" soluplus"> soluplus</a>, <a href="https://publications.waset.org/abstracts/search?q=solid%20dispersion%20technique" title=" solid dispersion technique"> solid dispersion technique</a> </p> <a href="https://publications.waset.org/abstracts/17833/solubility-enhancement-of-poorly-soluble-anticancer-drug-docetaxel-using-a-novel-polymer-soluplus-via-solid-dispersion-technique" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17833.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">502</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4934</span> In Silico Studies on Selected Drug Targets for Combating Drug Resistance in Plasmodium Falcifarum </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Deepika%20Bhaskar">Deepika Bhaskar</a>, <a href="https://publications.waset.org/abstracts/search?q=Neena%20Wadehra"> Neena Wadehra</a>, <a href="https://publications.waset.org/abstracts/search?q=Megha%20Gulati"> Megha Gulati</a>, <a href="https://publications.waset.org/abstracts/search?q=Aruna%20Narula"> Aruna Narula</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Vishnu"> R. Vishnu</a>, <a href="https://publications.waset.org/abstracts/search?q=Gunjan%20Katyal"> Gunjan Katyal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> With drug resistance becoming widespread in Plasmodium falciparum infections, development of the alternative drugs is the desired strategy for prevention and cure of malaria. Three drug targets were selected to screen promising drug molecules from the GSK library of around 14000 molecules. Using an in silico structure-based drug designing approach, the differences in binding energies of the substrate and inhibitor were exploited between target sites of parasite and human to design a drug molecule against Plasmodium. The docking studies have shown several promising molecules from GSK library with more effective binding as compared to the already known inhibitors for the drug targets. Though stronger interaction has been shown by several molecules as compare to reference, few molecules have shown the potential as drug candidates though in vitro studies are required to validate the results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=plasmodium" title="plasmodium">plasmodium</a>, <a href="https://publications.waset.org/abstracts/search?q=malaria" title=" malaria"> malaria</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20targets" title=" drug targets"> drug targets</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20silico%20studies" title=" in silico studies"> in silico studies</a> </p> <a href="https://publications.waset.org/abstracts/24319/in-silico-studies-on-selected-drug-targets-for-combating-drug-resistance-in-plasmodium-falcifarum" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24319.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">446</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4933</span> Potential Drug-Drug Interactions at a Referral Hematology-Oncology Ward in Iran: A Cross-Sectional Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sara%20Ataei">Sara Ataei</a>, <a href="https://publications.waset.org/abstracts/search?q=Molouk%20Hadjibabaie"> Molouk Hadjibabaie</a>, <a href="https://publications.waset.org/abstracts/search?q=Shirinsadat%20Badri"> Shirinsadat Badri</a>, <a href="https://publications.waset.org/abstracts/search?q=Amirhossein%20Moslehi"> Amirhossein Moslehi</a>, <a href="https://publications.waset.org/abstracts/search?q=Iman%20Karimzadeh"> Iman Karimzadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Ardeshir%20Ghavamzadeh"> Ardeshir Ghavamzadeh </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: To assess the pattern and probable risk factors for moderate and major drug–drug interactions in a referral hematology-oncology ward in Iran. Methods: All patients admitted to hematology–oncology ward of Dr. Shariati Hospital during a 6-month period and received at least two anti-cancer or non-anti-cancer medications simultaneously were included. All being scheduled anti-cancer and non-anti-cancer medications both prescribed and administered during ward stay were considered for drug–drug interaction screening by Lexi-Interact On- Desktop software. Results: One hundred and eighty-five drug–drug interactions with moderate or major severity were detected from 83 patients. Most of drug–drug interactions (69.73 %) were classified as pharmacokinetics. Fluconazole (25.95 %) was the most commonly offending medication in drug–drug interactions. Interaction of sulfamethoxazole-trimethoprim with fluconazole was the most common drug–drug interaction (27.27 %). Vincristine with imatinib was the only identified interaction between two anti-cancer agents. The number of administered medications during ward stay was considered as an independent risk factor for developing a drug–drug interaction. Conclusions: Potential moderate or major drug–drug interactions occur frequently in patients with hematological malignancies or related diseases. Performing larger standard studies are required to assess the real clinical and economical effects of drug–drug interactions on patients with hematological and non-hematological malignancies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%E2%80%93drug%20interactions" title="drug–drug interactions">drug–drug interactions</a>, <a href="https://publications.waset.org/abstracts/search?q=hematology%E2%80%93oncology%20ward" title=" hematology–oncology ward"> hematology–oncology ward</a>, <a href="https://publications.waset.org/abstracts/search?q=hematological%20malignancies" title=" hematological malignancies "> hematological malignancies </a> </p> <a href="https://publications.waset.org/abstracts/17983/potential-drug-drug-interactions-at-a-referral-hematology-oncology-ward-in-iran-a-cross-sectional-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17983.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">453</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4932</span> Using Combination of Sets of Features of Molecules for Aqueous Solubility Prediction: A Random Forest Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muhammet%20Baldan">Muhammet Baldan</a>, <a href="https://publications.waset.org/abstracts/search?q=Emel%20Timu%C3%A7in"> Emel Timuçin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Generally, absorption and bioavailability increase if solubility increases; therefore, it is crucial to predict them in drug discovery applications. Molecular descriptors and Molecular properties are traditionally used for the prediction of water solubility. There are various key descriptors that are used for this purpose, namely Drogan Descriptors, Morgan Descriptors, Maccs keys, etc., and each has different prediction capabilities with differentiating successes between different data sets. Another source for the prediction of solubility is structural features; they are commonly used for the prediction of solubility. However, there are little to no studies that combine three or more properties or descriptors for prediction to produce a more powerful prediction model. Unlike available models, we used a combination of those features in a random forest machine learning model for improved solubility prediction to better predict and, therefore, contribute to drug discovery systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=solubility" title="solubility">solubility</a>, <a href="https://publications.waset.org/abstracts/search?q=random%20forest" title=" random forest"> random forest</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20descriptors" title=" molecular descriptors"> molecular descriptors</a>, <a href="https://publications.waset.org/abstracts/search?q=maccs%20keys" title=" maccs keys"> maccs keys</a> </p> <a href="https://publications.waset.org/abstracts/186736/using-combination-of-sets-of-features-of-molecules-for-aqueous-solubility-prediction-a-random-forest-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186736.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">46</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4931</span> Measure of Pleasure of Drug Users</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vano%20Tsertsvadze">Vano Tsertsvadze</a>, <a href="https://publications.waset.org/abstracts/search?q=Marina%20Chavchanidze"> Marina Chavchanidze</a>, <a href="https://publications.waset.org/abstracts/search?q=Lali%20Khurtsia"> Lali Khurtsia</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Problem of drug use is often seen as a combination of psychological and social problems, but this problem can be considered as economically rational decision in the process of buying pleasure (looking after children, reading, harvesting fruits in the fall, sex, eating, etc.). Before the adoption of the decisions people face to a trade-off - when someone chooses a delicious meal, she takes a completely rational decision, that the pleasure of eating has a lot more value than the pleasure which she will experience after two months diet on the summer beach showing off her beautiful body. This argument is also true for alcohol, drugs and cigarettes. Smoking has a negative effect on health, but smokers are not afraid of the threat of a lung cancer after 40 years, more valuable moment is a pleasure from smoking. Our hypothesis - unsatisfied pleasure and frustration, probably determines the risk of dependence on drug abuse. The purpose of research: 1- to determine the relative measure unit of pleasure, which will be used to measure and assess the intensity of various human pleasures. 2- to compare the intensity of the pleasure from different kinds of activity, with pleasures received from drug use. 3- Based on the analysis of data, to identify factors affecting the rational decision making. Research method: Respondents will be asked to recall the greatest pleasure of their life, which will be used as a measure of the other pleasures. The study will use focus groups and structured interviews. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug" title="drug">drug</a>, <a href="https://publications.waset.org/abstracts/search?q=drug-user" title=" drug-user"> drug-user</a>, <a href="https://publications.waset.org/abstracts/search?q=measurement" title=" measurement"> measurement</a>, <a href="https://publications.waset.org/abstracts/search?q=satisfaction" title=" satisfaction "> satisfaction </a> </p> <a href="https://publications.waset.org/abstracts/37881/measure-of-pleasure-of-drug-users" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37881.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">321</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4930</span> Drug Use Knowledge and Antimicrobial Drug Use Behavior</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pimporn%20Thongmuang">Pimporn Thongmuang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The import value of antimicrobial drugs reached approximately fifteen million Baht in 2010, considered as the highest import value of all modern drugs, and this value is rising every year. Antimicrobials are considered the hazardous drugs by the Ministry of Public Health. This research was conducted in order to investigate the past knowledge of drug use and Antimicrobial drug use behavior. A total of 757 students were selected as the samples out of a population of 1,800 students. This selected students had the experience of Antimicrobial drugs use a year ago. A questionnaire was utilized in this research. The findings put on the view that knowledge gained by the students about proper use of antimicrobial drugs was not brought into practice. This suggests that the education procedure regarding drug use needs adjustment. And therefore the findings of this research are expected to be utilized as guidelines for educating people about the proper use of antimicrobial drugs. At a broader perspective, correct drug use behavior of the public may potentially reduce drug cost of the Ministry of Public Health of Thailand. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20use%20knowledge" title="drug use knowledge">drug use knowledge</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20drugs" title=" antimicrobial drugs"> antimicrobial drugs</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20use%20behavior" title=" drug use behavior"> drug use behavior</a>, <a href="https://publications.waset.org/abstracts/search?q=drug" title=" drug"> drug</a> </p> <a href="https://publications.waset.org/abstracts/3900/drug-use-knowledge-and-antimicrobial-drug-use-behavior" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/3900.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">280</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4929</span> In vitro P-Glycoprotein Modulation: Combinatorial Approach Using Natural Products</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jagdish%20S.%20Patel">Jagdish S. Patel</a>, <a href="https://publications.waset.org/abstracts/search?q=Piyush%20Chudasama"> Piyush Chudasama</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Context: Over-expression of P-glycoprotein (P-gp) plays critical role in absorption of many drug candidates which results into lower bioavailability of the drug. P-glycoprotein also over expresses in many pathological conditions like diabetes, affecting the drug therapy. Modulation of P-gp expression using inhibitors can help in designing novel formulation enhancing the bioavailability of the drug in question. Objectives: The main focus of the study was to develop advanced glycation end products (AGEs) induced P-gp over expression in Caco-2 cells. Curcumin, piperine and epigallocatechin gallate were used to evaluate their P-gp inhibitory action using combinatorial approach. Materials and methods: Methylglyoxal (MG) induced P-gp over expression was checked in Caco-2 cells using real time PCR. P-gp inhibitory effects of the phytochemicals were measured after induction with MG alone and in combination of any two compounds. Cytotoxicity of each of the phytochemical was evaluated using MTT assay. Results: Induction with MG (100mM) significantly induced the over expression of P-glycoprotein in Caco-2 cells after 24 hr. Curcumin, piperine and epigallocatechin gallate alone significantly reduced the level of P-gp within 6 hr of treatment period monitored by real time PCR. The combination of any two phytochemical also down regulated the expression of P-gp in cells. Combinations of Curcumin and epigallocatechin gallate have shown significant down regulation when compared with other two combinations. Conclusions: Combinatorial approach for down regulating the expression of P-gp, in pathological conditions like diabetes, has demonstrated promising approach for therapeutic purpose. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=p-glycoprotein" title="p-glycoprotein">p-glycoprotein</a>, <a href="https://publications.waset.org/abstracts/search?q=curcumin" title=" curcumin"> curcumin</a>, <a href="https://publications.waset.org/abstracts/search?q=piperine" title=" piperine"> piperine</a>, <a href="https://publications.waset.org/abstracts/search?q=epigallocatechin%20gallate" title=" epigallocatechin gallate"> epigallocatechin gallate</a>, <a href="https://publications.waset.org/abstracts/search?q=p-gp%20inhibition" title=" p-gp inhibition"> p-gp inhibition</a> </p> <a href="https://publications.waset.org/abstracts/43881/in-vitro-p-glycoprotein-modulation-combinatorial-approach-using-natural-products" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43881.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">334</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4928</span> Combination Therapies Targeting Apoptosis Pathways in Pediatric Acute Myeloid Leukemia (AML)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ahlam%20Ali">Ahlam Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Katrina%20Lappin"> Katrina Lappin</a>, <a href="https://publications.waset.org/abstracts/search?q=Jaine%20Blayney"> Jaine Blayney</a>, <a href="https://publications.waset.org/abstracts/search?q=Ken%20Mills"> Ken Mills</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Leukaemia is the most frequently (30%) occurring type of paediatric cancer. Of these, approximately 80% are acute lymphoblastic leukaemia (ALL) with acute myeloid leukaemia (AML) cases making up the remaining 20% alongside other leukaemias. Unfortunately, children with AML do not have promising prognosis with only 60% surviving 5 years or longer. It has been highlighted recently the need for age-specific therapies for AML patients, with paediatric AML cases having a different mutational landscape compared with AML diagnosed in adult patients. Drug Repurposing is a recognized strategy in drug discovery and development where an already approved drug is used for diseases other than originally indicated. We aim to identify novel combination therapies with the promise of providing alternative more effective and less toxic induction therapy options. Our in-silico analysis highlighted ‘cell death and survival’ as an aberrant, potentially targetable pathway in paediatric AML patients. On this basis, 83 apoptotic inducing compounds were screened. A preliminary single agent screen was also performed to eliminate potentially toxic chemicals, then drugs were constructed into a pooled library with 10 drugs per well over 160 wells, with 45 possible pairs and 120 triples in each well. Seven cell lines were used during this study to represent the clonality of AML in paediatric patients (Kasumi-1, CMK, CMS, MV11-14, PL21, THP1, MOLM-13). Cytotoxicity was assessed up to 72 hours using CellTox™ Green reagent. Fluorescence readings were normalized to a DMSO control. Z-Score was assigned to each well based on the mean and standard deviation of all the data. Combinations with a Z-Score <2 were eliminated and the remaining wells were taken forward for further analysis. A well was considered ‘successful’ if each drug individually demonstrated a Z-Score <2, while the combination exhibited a Z-Score >2. Each of the ten compounds in one well (155) had minimal or no effect as single agents on cell viability however, a combination of two or more of the compounds resulted in a substantial increase in cell death, therefore the ten compounds were de-convoluted to identify a possible synergistic pair/triple combinations. The screen identified two possible ‘novel’ drug pairing, with BCL2 inhibitor ABT-737, combined with either a CDK inhibitor Purvalanol A, or AKT/ PI3K inhibitor LY294002. (ABT-737- 100 nM+ Purvalanol A- 1 µM) (ABT-737- 100 nM+ LY294002- 2 µM). Three possible triple combinations were identified (LY2409881+Akti-1/2+Purvalanol A, SU9516+Akti-1/2+Purvalanol A, and ABT-737+LY2409881+Purvalanol A), which will be taken forward for examining their efficacy at varying concentrations and dosing schedules, across multiple paediatric AML cell lines for optimisation of maximum synergy. We believe that our combination screening approach has potential for future use with a larger cohort of drugs including FDA approved compounds and patient material. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=AML" title="AML">AML</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20repurposing" title=" drug repurposing"> drug repurposing</a>, <a href="https://publications.waset.org/abstracts/search?q=ABT-737" title=" ABT-737"> ABT-737</a>, <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title=" apoptosis"> apoptosis</a> </p> <a href="https://publications.waset.org/abstracts/141266/combination-therapies-targeting-apoptosis-pathways-in-pediatric-acute-myeloid-leukemia-aml" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141266.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">203</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4927</span> Drug-Drug Interaction Prediction in Diabetes Mellitus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rashini%20Maduka">Rashini Maduka</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20R.%20Wijesinghe"> C. R. Wijesinghe</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20R.%20Weerasinghe"> A. R. Weerasinghe</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Drug-drug interactions (DDIs) can happen when two or more drugs are taken together. Today DDIs have become a serious health issue due to adverse drug effects. In vivo and in vitro methods for identifying DDIs are time-consuming and costly. Therefore, in-silico-based approaches are preferred in DDI identification. Most machine learning models for DDI prediction are used chemical and biological drug properties as features. However, some drug features are not available and costly to extract. Therefore, it is better to make automatic feature engineering. Furthermore, people who have diabetes already suffer from other diseases and take more than one medicine together. Then adverse drug effects may happen to diabetic patients and cause unpleasant reactions in the body. In this study, we present a model with a graph convolutional autoencoder and a graph decoder using a dataset from DrugBank version 5.1.3. The main objective of the model is to identify unknown interactions between antidiabetic drugs and the drugs taken by diabetic patients for other diseases. We considered automatic feature engineering and used Known DDIs only as the input for the model. Our model has achieved 0.86 in AUC and 0.86 in AP. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug-drug%20interaction%20prediction" title="drug-drug interaction prediction">drug-drug interaction prediction</a>, <a href="https://publications.waset.org/abstracts/search?q=graph%20embedding" title=" graph embedding"> graph embedding</a>, <a href="https://publications.waset.org/abstracts/search?q=graph%20convolutional%20networks" title=" graph convolutional networks"> graph convolutional networks</a>, <a href="https://publications.waset.org/abstracts/search?q=adverse%20drug%20effects" title=" adverse drug effects"> adverse drug effects</a> </p> <a href="https://publications.waset.org/abstracts/165305/drug-drug-interaction-prediction-in-diabetes-mellitus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165305.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">100</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4926</span> Spray-Dried, Biodegradable, Drug-Loaded Microspheres for Use in the Treatment of Lung Diseases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mazen%20AlGharsan">Mazen AlGharsan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: The Carbopol Microsphere of Linezolid, a drug used to treat lung disease (pulmonary disease), was prepared using Buchi B-90 nano spray-drier. Methods: Production yield, drug content, external morphology, particle size, and in vitro release pattern were performed. Results: The work was 79.35%, and the drug content was 66.84%. The surface of the particles was shriveled in shape, with particle size distribution with a mean diameter of 9.6 µm; the drug was released in a biphasic manner with an initial release of 25.2 ± 5.7% at 60 minutes. It later prolonged the release by 95.5 ± 2.5% up to 12 hours. Differential scanning calorimetry (DSC) revealed no change in the melting point of the formulation. Fourier-transform infrared (FT-IR) studies showed no polymer-drug interaction in the prepared nanoparticles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanotechnology" title="nanotechnology">nanotechnology</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=Linezolid" title=" Linezolid"> Linezolid</a>, <a href="https://publications.waset.org/abstracts/search?q=lung%20disease" title=" lung disease"> lung disease</a> </p> <a href="https://publications.waset.org/abstracts/193025/spray-dried-biodegradable-drug-loaded-microspheres-for-use-in-the-treatment-of-lung-diseases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/193025.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">13</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4925</span> Development of an Erodable Matrix Drug Delivery Platform for Controled Delivery of Non Steroidal Anti Inflamatory Drugs Using Melt Granulation Process</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20Hilsana">A. Hilsana</a>, <a href="https://publications.waset.org/abstracts/search?q=Vinay%20U.%20Rao"> Vinay U. Rao</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Sudhakar"> M. Sudhakar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Even though a number of non-steroidal anti-inflammatory drugs (NSAIDS) are available with different chemistries, they share a common solubility characteristic that is they are relatively more soluble in alkaline environment and practically insoluble in acidic environment. This work deals with developing a wax matrix drug delivery platform for controlled delivery of three model NSAIDS, Diclofenac sodium (DNa), Mefenamic acid (MA) and Naproxen (NPX) using the melt granulation technique. The aim of developing the platform was to have a general understanding on how an erodible matrix system modulates drug delivery rate and extent and how it can be optimized to give a delivery system which shall release the drug as per a common target product profile (TPP). Commonly used waxes like Cetostearyl alcohol and stearic acid were used singly an in combination to achieve a TPP of not 15 to 35% in 1 hour and not less than 80% Q in 24 hours. Full factorial design of experiments was followed for optimization of the formulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=NSAIDs" title="NSAIDs">NSAIDs</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled%20delivery" title=" controlled delivery"> controlled delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=target%20product%20profile" title=" target product profile"> target product profile</a>, <a href="https://publications.waset.org/abstracts/search?q=melt%20granulation" title=" melt granulation"> melt granulation</a> </p> <a href="https://publications.waset.org/abstracts/9021/development-of-an-erodable-matrix-drug-delivery-platform-for-controled-delivery-of-non-steroidal-anti-inflamatory-drugs-using-melt-granulation-process" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9021.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">334</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4924</span> Role of Social Support in Drug Cessation among Male Addicts in the West of Iran</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Jalilian">Farzad Jalilian</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehdi%20Mirzaei%20Alavijeh"> Mehdi Mirzaei Alavijeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Fazel%20Zinat%20Motlagh"> Fazel Zinat Motlagh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Social support is an important benchmark of health for people in avoidance conditions. The main goal of this study was to determine the three kinds of social support (family, friend and other significant) to drug cessation among male addicts, in Kermanshah, the west of Iran. This cross-sectional study was conducted among 132 addicts, randomly selected to participate voluntarily in the study. Data were collected from conduct interviews based on standard questionnaire and analyzed by using SPSS-18 at 95% significance level. The majority of addicts were young (Mean: 30.4 years), and with little education. Opium (36.4%), Crack (21.2%), and Methamphetamine (12.9%) were the predominant drugs. Inabilities to reject the offer and having addict friends are the most often reasons for drug usage. Almost, 18.9% reported history of drug injection. 43.2% of the participants already did drug cessation at least once. Logistic regression showed the family support (OR = 1.110), age (OR = 1.106) and drug use initiation age (OR = 0.918) was predicting drug cessation. Our result showed; family support is a more important effect among types of social support in drug cessation. It seems that providing educational program to addict’s families for more support of patients at drug cessation can be beneficial. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20cessation" title="drug cessation">drug cessation</a>, <a href="https://publications.waset.org/abstracts/search?q=family%20support" title=" family support"> family support</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20use" title=" drug use"> drug use</a>, <a href="https://publications.waset.org/abstracts/search?q=initiation%20age" title=" initiation age"> initiation age</a> </p> <a href="https://publications.waset.org/abstracts/33735/role-of-social-support-in-drug-cessation-among-male-addicts-in-the-west-of-iran" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33735.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">550</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4923</span> Functionalized Nanoparticles for Drug Delivery Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Temesgen%20Geremew">Temesgen Geremew</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Functionalized nanoparticles have emerged as a revolutionary platform for drug delivery, offering significant advantages over traditional methods. By strategically modifying their surface properties, these nanoparticles can be designed to target specific tissues and cells, significantly reducing off-target effects and enhancing therapeutic efficacy. This targeted approach allows for lower drug doses, minimizing systemic exposure and potential side effects. Additionally, functionalization enables controlled release of the encapsulated drug, improving drug stability and reducing the frequency of administration, leading to improved patient compliance. This work explores the immense potential of functionalized nanoparticles in revolutionizing drug delivery, addressing limitations associated with conventional therapies and paving the way for personalized medicine with precise and targeted treatment strategies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title="nanoparticles">nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=drug" title=" drug"> drug</a>, <a href="https://publications.waset.org/abstracts/search?q=nanomaterials" title=" nanomaterials"> nanomaterials</a>, <a href="https://publications.waset.org/abstracts/search?q=applications" title=" applications"> applications</a> </p> <a href="https://publications.waset.org/abstracts/183288/functionalized-nanoparticles-for-drug-delivery-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/183288.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">67</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4922</span> Formulation and Evaluation of Lisinopril Microspheres for Nasal Delivery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20S.%20Patil">S. S. Patil</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20M.%20Mhetre"> R. M. Mhetre</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20V.%20Patil"> S. V. Patil </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Lisinopril is an angiotensin converting enzyme inhibitor used in the treatment of hypertension and heart failure in prophylactic treatment after myocardial infarction and in diabetic nephropathy. However, it is very poorly absorbed from gastro-intestinal tract. Intranasal administration is an ideal alternative to the parenteral route for systemic drug delivery. Formulating multiparticulate system with mucoadhesive polymers provide a significant increase in the nasal residence time. The aim of the present approach was to overcome the drawbacks of the conventional dosage forms of lisinopril by formulating intranasal microspheres with Carbopol 974P NF and HPMC K4 M along with film forming polymer ethyl cellulose.The microspheres were prepared by emulsion solvent evaporation method. The prepared microspheres were characterized for encapsulation efficiency, drug loading, particle size, and surface morphology, degree of swelling, ex vivo mucoadhesion, drug release, ex vivo diffusion studies. All formulations has shown entrapment efficiency between 80 to more than 95%, mucoadhesion was more than 80 % and drug release up to 90 %. Ex vivo studies revealed tht the improved bioavailability of drug compared to oral drug administration. Both in vitro and in vivo studies conclude that combination of Carbopol and HPMC based microspheres shown better results than single carbopol based microspheres for the delivery of lisinopril. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=microspheres" title="microspheres">microspheres</a>, <a href="https://publications.waset.org/abstracts/search?q=lisinopril" title=" lisinopril"> lisinopril</a>, <a href="https://publications.waset.org/abstracts/search?q=nasal%20delivery" title=" nasal delivery"> nasal delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=solvent%20evaporation%20method" title=" solvent evaporation method"> solvent evaporation method</a> </p> <a href="https://publications.waset.org/abstracts/22193/formulation-and-evaluation-of-lisinopril-microspheres-for-nasal-delivery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22193.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">528</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4921</span> Pharmaceutical Science and Development in Drug Research</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adegoke%20Yinka%20Adebayo">Adegoke Yinka Adebayo </a> </p> <p class="card-text"><strong>Abstract:</strong></p> An understanding of the critical product attributes that impact on in vivo performance is key to the production of safe and effective medicines. Thus, a key driver for our research is the development of new basic science and technology underpinning the development of new pharmaceutical products. Research includes the structure and properties of drugs and excipients, biopharmaceutical characterisation, pharmaceutical processing and technology and formulation and analysis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20discovery" title="drug discovery">drug discovery</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20development" title=" drug development"> drug development</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery "> drug delivery </a> </p> <a href="https://publications.waset.org/abstracts/19017/pharmaceutical-science-and-development-in-drug-research" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19017.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">494</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4920</span> Management Practices in Hypertension: Results of Win-Over-A Pan India Registry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abhijit%20Trailokya">Abhijit Trailokya</a>, <a href="https://publications.waset.org/abstracts/search?q=Kamlesh%20Patel"> Kamlesh Patel </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Hypertension is a common disease seen in clinical practice and is associated with high morbidity and mortality. Many patients require combination therapy for the management of hypertension. Objective: To evaluate co-morbidities, risk factors and management practices of hypertension in Indian population. Material and methods: A total of 1596 hypertensive adult patients received anti-hypertensive medications were studied in a cross-sectional, multi-centric, non-interventional, observational registry. Statistical analysis: Categories or nominal data was expressed as numbers with percentages. Continuous variables were analyzed by descriptive statistics using mean, SD, and range Chi square test was used for in between group comparison. Results: The study included 73.50% males and 26.50% females. Overweight (50.50%) and obesity (30.01%) was common in the hypertensive patients (n=903). A total of 54.76% patients had history of smoking. Alcohol use (33.08%), sedentary life style (32.96%) and history of tobacco chewing (17.92%) were the other lifestyle habits of hypertensive patients. Diabetes (36.03%) and dyslipidemia (39.79%) history was common in these patients. Family history of hypertension and diabetes was seen in 82.21% and 45.99% patients respectively. Most (89.16%) patients were treated with combination of antihypertensive agents. ARBs were the by far most commonly used agents (91.98%) followed by calcium channel blockers (68.23%) and diuretics (60.21%). ARB was the most (80.35%) preferred agent as monotherapy. ARB was also the most common agent as a component of dual therapy, four drug and five drug combinations. Conclusion: Most of the hypertensive patients need combination treatment with antihypertensive agents. ARBs are the most preferred agents as monotherapy for the management of hypertension. ARBs are also very commonly used as a component of combination therapy during hypertension management. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antihypertensive" title="antihypertensive">antihypertensive</a>, <a href="https://publications.waset.org/abstracts/search?q=hypertension" title=" hypertension"> hypertension</a>, <a href="https://publications.waset.org/abstracts/search?q=management" title=" management"> management</a>, <a href="https://publications.waset.org/abstracts/search?q=ARB" title=" ARB"> ARB</a> </p> <a href="https://publications.waset.org/abstracts/17885/management-practices-in-hypertension-results-of-win-over-a-pan-india-registry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17885.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">521</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4919</span> Spatial Relationship of Drug Smuggling Based on Geographic Information System Knowledge Discovery Using Decision Tree Algorithm</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Niamkaeo">S. Niamkaeo</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Robert"> O. Robert</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Chaowalit"> O. Chaowalit</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this investigation, we focus on discovering spatial relationship of drug smuggling along the northern border of Thailand. Thailand is no longer a drug production site, but Thailand is still one of the major drug trafficking hubs due to its topographic characteristics facilitating drug smuggling from neighboring countries. Our study areas cover three districts (Mae-jan, Mae-fahluang, and Mae-sai) in Chiangrai city and four districts (Chiangdao, Mae-eye, Chaiprakarn, and Wienghang) in Chiangmai city where drug smuggling of methamphetamine crystal and amphetamine occurs mostly. The data on drug smuggling incidents from 2011 to 2017 was collected from several national and local published news. Geo-spatial drug smuggling database was prepared. Decision tree algorithm was applied in order to discover the spatial relationship of factors related to drug smuggling, which was converted into rules using rule-based system. The factors including land use type, smuggling route, season and distance within 500 meters from check points were found that they were related to drug smuggling in terms of rules-based relationship. It was illustrated that drug smuggling was occurred mostly in forest area in winter. Drug smuggling exhibited was discovered mainly along topographic road where check points were not reachable. This spatial relationship of drug smuggling could support the Thai Office of Narcotics Control Board in surveillance drug smuggling. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=decision%20tree" title="decision tree">decision tree</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20smuggling" title=" drug smuggling"> drug smuggling</a>, <a href="https://publications.waset.org/abstracts/search?q=Geographic%20Information%20System" title=" Geographic Information System"> Geographic Information System</a>, <a href="https://publications.waset.org/abstracts/search?q=GIS%20knowledge%20discovery" title=" GIS knowledge discovery"> GIS knowledge discovery</a>, <a href="https://publications.waset.org/abstracts/search?q=rule-based%20system" title=" rule-based system"> rule-based system</a> </p> <a href="https://publications.waset.org/abstracts/99772/spatial-relationship-of-drug-smuggling-based-on-geographic-information-system-knowledge-discovery-using-decision-tree-algorithm" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/99772.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">169</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4918</span> COX-2 Inhibitor NS398 Counteracts Chemoresistance to Temozolomide in T98G Glioblastoma Cell Line</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Francesca%20Lombardi">Francesca Lombardi</a>, <a href="https://publications.waset.org/abstracts/search?q=Francesca%20Rosaria%20Augello"> Francesca Rosaria Augello</a>, <a href="https://publications.waset.org/abstracts/search?q=Benedetta%20Cinque"> Benedetta Cinque</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Grazia%20Cifone"> Maria Grazia Cifone</a>, <a href="https://publications.waset.org/abstracts/search?q=Paola%20Palumbo"> Paola Palumbo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Glioblastoma multiforme (GBM) is a high-grade primary brain tumor refractory to current forms of treatment. The survival benefits of patients with GBM remain unsatisfactory due to the intrinsic or acquired resistance to temozolomide (TMZ), an alkylating agent, used as the first-line chemotherapeutic drug to treat GBM patients. Its cytotoxic effect is visualized by the induction of O6-methylguanine (O6MeG) within DNA. Cyclooxygenase-2 (COX-2), an inflammation-associated enzyme, has been implicated in tumorigenesis and progression of GBM, its inhibition shows anticancer activities. In the present study, it was verified if the combination of a COX-2 selective inhibitor, NS398, with TMZ could counteract the TMZ resistance. In particular, the effect of NS398 mixed with TMZ was investigated in the GBM TMZ-resistant cell line, T98G. Cells were pretreated with NS398 (100µM, 24 hours) and then exposed to TMZ alone (200µM), NS398 alone, or both for 72 hours, after which cell growth rate and cycle phases, as well as apoptosis level, were evaluated. Coadministration of NS398 and TMZ caused a significant decrease in cell growth and a progressive increase of dead cells detected by trypan blue staining. Moreover, a significant level of apoptotic cell percentage and alteration of cell cycle phases were observed in T98G treated with TMZ-NS398 combination when compared to untreated cells or TMZ-treated cells. TMZ-resistant tumors, as GBM, express elevated levels of DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT). The mixture drastically reduced MGMT expression in the TMZ-resistant cell line T98G, known to express high levels of MGMT basically. Moreover, while TMZ alone did not influence the COX-2 protein expression, the combination successfully reduced it. In conclusion, these results demonstrated that NS398 enhanced the efficacy of TMZ through cell number reduction, apoptosis induction, and decreased MGMT levels, suggesting the ability of drug combination to reduce the chemoresistance. This drug combination deserves attention and could be considered as a promising therapeutic strategy for GBM patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=COX-2" title="COX-2">COX-2</a>, <a href="https://publications.waset.org/abstracts/search?q=COX-2%20inhibitor" title=" COX-2 inhibitor"> COX-2 inhibitor</a>, <a href="https://publications.waset.org/abstracts/search?q=glioblastoma" title=" glioblastoma"> glioblastoma</a>, <a href="https://publications.waset.org/abstracts/search?q=NS398" title=" NS398"> NS398</a>, <a href="https://publications.waset.org/abstracts/search?q=T98G" title=" T98G"> T98G</a>, <a href="https://publications.waset.org/abstracts/search?q=temozolomide" title=" temozolomide"> temozolomide</a> </p> <a href="https://publications.waset.org/abstracts/129238/cox-2-inhibitor-ns398-counteracts-chemoresistance-to-temozolomide-in-t98g-glioblastoma-cell-line" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/129238.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">152</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4917</span> Pain Management in Burn Wounds with Dual Drug Loaded Double Layered Nano-Fiber Based Dressing</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sharjeel%20Abid">Sharjeel Abid</a>, <a href="https://publications.waset.org/abstracts/search?q=Tanveer%20Hussain"> Tanveer Hussain</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahsan%20Nazir"> Ahsan Nazir</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdul%20Zahir"> Abdul Zahir</a>, <a href="https://publications.waset.org/abstracts/search?q=Nabyl%20Khenoussi"> Nabyl Khenoussi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Localized application of drug has various advantages and fewer side effects as compared with other methods. Burn patients suffer from swear pain and the major aspects that are considered for burn victims include pain and infection management. Nano-fibers (NFs) loaded with drug, applied on local wound area, can solve these problems. Therefore, this study dealt with the fabrication of drug loaded NFs for better pain management. Two layers of NFs were fabricated with different drugs. Contact layer was loaded with Gabapentin (a nerve painkiller) and the second layer with acetaminophen. The fabricated dressing was characterized using scanning electron microscope, Fourier Transform Infrared Spectroscopy, X-Ray Diffraction and UV-Vis Spectroscopy. The double layered based NFs dressing was designed to have both initial burst release followed by slow release to cope with pain for two days. The fabricated nanofibers showed diameter < 300 nm. The liquid absorption capacity of the NFs was also checked to deal with the exudate. The fabricated double layered dressing with dual drug loading and release showed promising results that could be used for dealing pain in burn victims. It was observed that by the addition of drug, the size of nanofibers was reduced, on the other hand, the crystallinity %age was increased, and liquid absorption decreased. The combination of fast nerve pain killer release followed by slow release of non-steroidal anti-inflammatory drug could be a good tool to reduce pain in a more secure manner with fewer side effects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pain%20management" title="pain management">pain management</a>, <a href="https://publications.waset.org/abstracts/search?q=burn%20wounds" title=" burn wounds"> burn wounds</a>, <a href="https://publications.waset.org/abstracts/search?q=nano-fibers" title=" nano-fibers"> nano-fibers</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled%20drug%20release" title=" controlled drug release"> controlled drug release</a> </p> <a href="https://publications.waset.org/abstracts/94600/pain-management-in-burn-wounds-with-dual-drug-loaded-double-layered-nano-fiber-based-dressing" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/94600.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">253</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4916</span> Functionalized DOX Nanocapsules by Iron Oxide Nanoparticles for Targeted Drug Delivery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Afsaneh%20Ghorbanzadeh">Afsaneh Ghorbanzadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Afshin%20Farahbakhsh"> Afshin Farahbakhsh</a>, <a href="https://publications.waset.org/abstracts/search?q=Zakieh%20Bayat"> Zakieh Bayat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The drug capsulation was used for release and targeted delivery in determined time, place and temperature or pH. The DOX nanocapsules were used to reduce and to minimize the unwanted side effects of drug. In this paper, the encapsulation methods of doxorubicin (DOX) and the labeling it by the magnetic core of iron (Fe3O4) has been studied. The Fe3O4 was conjugated with DOX via hydrazine bond. The solution was capsuled by the sensitive polymer of heat or pH such as chitosan-g-poly (N-isopropylacrylamide-co-N,N-dimethylacrylamide), dextran-g-poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) and mPEG-G2.5 PAMAM by hydrazine bond. The drug release was very slow at temperatures lower than 380°C. There was a rapid and controlled drug release at temperatures higher than 380°C. According to experiments, the use mPEG-G2.5PAMAM is the best method of DOX nanocapsules synthesis, because in this method, the drug delivery time to certain place is lower than other methods and the percentage of released drug is higher. The synthesized magnetic carrier system has potential applications in magnetic drug-targeting delivery and magnetic resonance imaging. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20carrier" title="drug carrier">drug carrier</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title=" drug release"> drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=doxorubicin" title=" doxorubicin"> doxorubicin</a>, <a href="https://publications.waset.org/abstracts/search?q=iron%20oxide%20NPs" title=" iron oxide NPs"> iron oxide NPs</a> </p> <a href="https://publications.waset.org/abstracts/9068/functionalized-dox-nanocapsules-by-iron-oxide-nanoparticles-for-targeted-drug-delivery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9068.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">417</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4915</span> Combination of Lamotrigine and Duloxetine: A Potential Approach for the Treatment of Acute Bipolar Depression</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kedar%20S.%20Prabhavalkar">Kedar S. Prabhavalkar</a>, <a href="https://publications.waset.org/abstracts/search?q=Nimmy%20Baby%20Poovanpallil"> Nimmy Baby Poovanpallil</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Lamotrigine is approved for maintenance treatment of bipolar I disorder. However, its role in the treatment of acute bipolar depression is not well clear. Its efficacy in the treatment of major depressive disorders including refractory unipolar depression suggested the use of lamotrigine as an augmentation drug for acute bipolar depression. The present study aims to evaluate and perform a comparative analysis of the therapeutic effects of lamotrigine, an epileptic mood stabilizer, when used alone and in combination with duloxetine in treating acute bipolar depression at different doses of lamotrigine. Male swiss albino mice were used. For evaluation of efficacy of combination, immobility period was analyzed 30 min after the treatment from forced swim and tail suspension tests. Further amount of sucrose consumed in sucrose preference test was estimated. The combination of duloxetine and lamotrigine showed potentiation of antidepressant activity in acute models. Decrease in immobility time and increase in the amount of sucrose consumption in stressed mice were higher in combined group compared to lamotrigine monotherapy group. Brain monoamine levels were also attenuated more with combination compared to monotherapy. Results of the present study suggest potential role of lamotrigine and duloxetine combination in the treatment of acute bipolar depression. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lamotrigine" title="lamotrigine">lamotrigine</a>, <a href="https://publications.waset.org/abstracts/search?q=duloxetine" title=" duloxetine"> duloxetine</a>, <a href="https://publications.waset.org/abstracts/search?q=acute%20bipolar%20depression" title=" acute bipolar depression"> acute bipolar depression</a>, <a href="https://publications.waset.org/abstracts/search?q=augmentation" title=" augmentation"> augmentation</a> </p> <a href="https://publications.waset.org/abstracts/43929/combination-of-lamotrigine-and-duloxetine-a-potential-approach-for-the-treatment-of-acute-bipolar-depression" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43929.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">507</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4914</span> Prevalence of Drug Injection among Male Prisoners in the West of Iran</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Jalilian">Farzad Jalilian</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehdi%20Mirzaei%20Alavijeh"> Mehdi Mirzaei Alavijeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Substance addiction is one of the major worldwide problems that destroys economy, familial relationships, and the abuser’s career and has several side effects; in the meantime drug injection due to the possibility of shared use of syringes among drug users could have multiple complications to be followed. The purpose of this study was to determine the prevalence of drug injection among male prisoners in Kermanshah city, the west of Iran. Methods: In this cross-sectional study 615 male prisoners were randomly selected to participate voluntarily in the study. Participants filled out a writing self-report questionnaire. Data were analyzed by the SPSS software (ver. 21.0) at 95% significant level. Results: The mean age of respondents was 31.13 years [SD: 7.76]. Mean initiation age for drug use was 14.36 years (range, 9-34 years). Almost, 39.4 % reported a history of drug use before prison. Opium (33.2%) and crystal (27.1%) was the most used drug among prisoners. Furthermore, 9.3 % had a history of injection addiction. There was a significant correlation between age, crime type, marital status, economic status, unprotected sex and drug injection (P < 0.05). Conclusion: The low age of drug abuse and the prevalence of drug injection among offenders can be as a warning for responsible; in this regard, implementation of prevention programs to risky behavior and harm reduction among high-risk groups can follow useful results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=substance%20abuse" title="substance abuse">substance abuse</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20injection" title=" drug injection"> drug injection</a>, <a href="https://publications.waset.org/abstracts/search?q=prison" title=" prison"> prison</a>, <a href="https://publications.waset.org/abstracts/search?q=Iran" title=" Iran"> Iran</a> </p> <a href="https://publications.waset.org/abstracts/33740/prevalence-of-drug-injection-among-male-prisoners-in-the-west-of-iran" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33740.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">485</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4913</span> Modeling Optimal Lipophilicity and Drug Performance in Ligand-Receptor Interactions: A Machine Learning Approach to Drug Discovery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jay%20Ananth">Jay Ananth</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The drug discovery process currently requires numerous years of clinical testing as well as money just for a single drug to earn FDA approval. For drugs that even make it this far in the process, there is a very slim chance of receiving FDA approval, resulting in detrimental hurdles to drug accessibility. To minimize these inefficiencies, numerous studies have implemented computational methods, although few computational investigations have focused on a crucial feature of drugs: lipophilicity. Lipophilicity is a physical attribute of a compound that measures its solubility in lipids and is a determinant of drug efficacy. This project leverages Artificial Intelligence to predict the impact of a drug’s lipophilicity on its performance by accounting for factors such as binding affinity and toxicity. The model predicted lipophilicity and binding affinity in the validation set with very high R² scores of 0.921 and 0.788, respectively, while also being applicable to a variety of target receptors. The results expressed a strong positive correlation between lipophilicity and both binding affinity and toxicity. The model helps in both drug development and discovery, providing every pharmaceutical company with recommended lipophilicity levels for drug candidates as well as a rapid assessment of early-stage drugs prior to any testing, eliminating significant amounts of time and resources currently restricting drug accessibility. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20discovery" title="drug discovery">drug discovery</a>, <a href="https://publications.waset.org/abstracts/search?q=lipophilicity" title=" lipophilicity"> lipophilicity</a>, <a href="https://publications.waset.org/abstracts/search?q=ligand-receptor%20interactions" title=" ligand-receptor interactions"> ligand-receptor interactions</a>, <a href="https://publications.waset.org/abstracts/search?q=machine%20learning" title=" machine learning"> machine learning</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20development" title=" drug development"> drug development</a> </p> <a href="https://publications.waset.org/abstracts/163127/modeling-optimal-lipophilicity-and-drug-performance-in-ligand-receptor-interactions-a-machine-learning-approach-to-drug-discovery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163127.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">111</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=drug%20combination&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=drug%20combination&page=3">3</a></li> <li class="page-item"><a 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