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Using our proprietary protein barcodes, mCodes™, our platform enables simultaneously characterizing hundreds-to-thousands of drug candidates in the context that matters most, inside living organisms. Screening at scale <em>in vivo</em> unlocks precision drug engineering, leading to better treatments for patients and positive impact on global health.</p></div></div></div></div></div></div></div><div class="platform_content-group"><div class="padding-global"><div class="container-large"><img src="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6463a2b3aca734e665ad691b_Background%20element.webp" loading="lazy" alt="" width="217" class="platform_background-element-1"/><div class="padding-section-medium"><div class="max-width-xlarge"><div class="text-style-spaced"><h2 class="heading-style-h3">Our Engineering Philosophy</h2></div><div class="padding-bottom padding-small"></div><div class="text-color-teal"><h3 class="heading-style-hero">Accelerating Drug Design with High-Throughput Screening <em>In Vivo</em></h3><div class="padding-bottom padding-medium"></div></div></div><div class="max-width-large"><p>Drug pharmacokinetics (PK), specifically stability and biodistribution, are key indicators of drug efficacy and safety. Traditionally, testing these properties is limited to only a few drug candidates towards the end of a drug discovery pipeline, given the challenge of scaling preclinical animal studies. <br/><br/>At Manifold Bio, we are able to test many drug designs simultaneously in a limited number of animal models as a core early step in the design process. Measured properties such as molecule half-life and rates of tumor and healthy tissue accumulation guide our engineering to optimize drug performance.</p></div></div></div></div><div class="div-block-29"><div class="padding-global"><div class="container-large"><div class="padding-section-medium"><div class="max-width-xlarge"><div class="text-style-spaced"><h2 class="heading-style-h3">How it Works</h2></div><div class="padding-bottom padding-small"></div><div class="text-color-teal"><h3 class="heading-style-h1">mCodes™ Protein Barcoding</h3><div class="padding-bottom padding-medium"></div></div></div><div class="max-width-xlarge"><p>To enable multiplexed drug tracking, Manifold Bio invented a first-of-its-kind technology called protein barcoding, or mCodes™, that allows for unique tracking and quantitation of any protein or library of proteins of interest (POI). mCodes can be genetically encoded with a POI, easily expressed, and are stable and inert <em>in vivo</em>. Through our proprietary mQuant™ assay, mCode peptides are transformed into DNA sequences, read out by next-generation DNA sequencing, and decoded to absolute protein levels.</p></div></div></div></div></div><div class="div-block-23"><img src="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487ad214e4c6422f5d69a47_dna-sequence.png" loading="lazy" sizes="(max-width: 1439px) 100vw, 1424px" srcset="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487ad214e4c6422f5d69a47_dna-sequence-p-500.png 500w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487ad214e4c6422f5d69a47_dna-sequence-p-800.png 800w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487ad214e4c6422f5d69a47_dna-sequence-p-1080.png 1080w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487ad214e4c6422f5d69a47_dna-sequence-p-1600.png 1600w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487ad214e4c6422f5d69a47_dna-sequence-p-2000.png 2000w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487ad214e4c6422f5d69a47_dna-sequence-p-2600.png 2600w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487ad214e4c6422f5d69a47_dna-sequence.png 2828w" alt="" class="image-21"/><img src="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487b9cf02b4544a36aee9c6_Frame%2047756.png" loading="lazy" sizes="100vw" srcset="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487b9cf02b4544a36aee9c6_Frame%2047756-p-500.png 500w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487b9cf02b4544a36aee9c6_Frame%2047756-p-800.png 800w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487b9cf02b4544a36aee9c6_Frame%2047756-p-1080.png 1080w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487b9cf02b4544a36aee9c6_Frame%2047756.png 1488w" alt="" class="image-21-copy"/><div class="padding-global"><div class="container-large"><img src="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6463a2b3aca734e665ad691b_Background%20element.webp" loading="lazy" alt="" width="217" class="platform_background-element-2"/><div class="div-block-24"><div class="div-block-25"><div class="div-block-27"><h2>Protein multiplexing via DNA sequencing</h2><div class="padding-bottom padding-small"></div><div class="text-color-teal"><div class="text-weight-bold"><div class="heading-style-h4">Proprietary Manifold Technology converts protein to DNA</div></div></div></div></div><div class="div-block-26"><div class="text-color-teal"><div class="text-weight-bold"><div class="heading-style-h4">Next-generation DNA Sequencing enables counting</div><div class="padding-bottom padding-small"></div></div></div><img src="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6487a95fc58d392b8aecdc58_chart.jpg" loading="lazy" alt=""/></div></div></div></div></div><div class="div-block-28"><div class="padding-global"><div class="container-large"><div class="padding-section-medium"><div class="global-2-col-75-25"><div><h2 class="heading-style-h2">mDesign™: Early <em>In Vivo</em> Testing Informs Drug Design</h2><div class="padding-bottom padding-medium"></div><p>mDesign accelerates the drug discovery process by collecting rich biodistribution data <em>in vivo</em> for hundreds of molecules early in the design cycle. Combining high-throughput <em>in vitro</em> and <em>in vivo</em> data, Manifold Bio can rapidly engineer complex biologics to eliminate poor characteristics and seek optimal protein therapeutic designs with improved likelihood of success in development and translation to clinical trials.</p></div><img src="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6463e3c65d9cebf026739f85_AnishaLab.jpg" loading="lazy" width="491" id="w-node-_56c1fbbc-5063-d3e8-7f63-16b09bdd62be-6d27e53e" alt="" srcset="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6463e3c65d9cebf026739f85_AnishaLab-p-500.jpg 500w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6463e3c65d9cebf026739f85_AnishaLab-p-800.jpg 800w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6463e3c65d9cebf026739f85_AnishaLab-p-1080.jpg 1080w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6463e3c65d9cebf026739f85_AnishaLab-p-1600.jpg 1600w, https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6463e3c65d9cebf026739f85_AnishaLab.jpg 2143w" sizes="(max-width: 767px) 90vw, (max-width: 991px) 491px, (max-width: 1439px) 41vw, 491px" class="image-rounded-corners"/></div></div></div></div></div><div class="padding-section-medium"><div class="padding-custom1-copy"><div class="container-large"><div class="global-2-col-75-25"><img src="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6463af15ef8d61d2ac650861_Graph2.svg" loading="lazy" width="595" id="w-node-e8005872-2470-2ace-59c9-dade0f66bebf-6d27e53e" alt=""/><div id="w-node-e8005872-2470-2ace-59c9-dade0f66bec0-6d27e53e"><div><div class="text-style-spaced"><h2 class="heading-style-h2-copy">Harnessing Machine Learning at Every Step</h2></div></div><div class="padding-bottom padding-medium"></div><div class="padding-right padding-xlarge"><p class="paragraph-2">Everything from the design of oligopool-encoded naïve binder libraries to studying our unique rich multiplex data requires a variety of cutting edge ML and statistical approaches. Our data-driven approach to drug design gives researchers and partners a unique edge in engineering more effective treatments.</p></div></div></div></div></div></div><div class="padding-global"><div class="container-large"><div class="padding-section-medium"><div class="global-2-col-25-75"><div><div class="text-color-teal"><div class="text-style-spaced"><h3 class="heading-style-h2">Versatility across therapeutic areas</h3></div><div class="padding-bottom padding-medium"></div></div></div><div><p>Manifold Bio's groundbreaking platform is designed to adapt to a wide range of drug discovery projects, tackling complex challenges across indications where targeting is a key challenge, including oncology, neuroscience, and rare disease. Our modular components and targeted effectors drive success in various therapeutic areas and revolutionize the drug development process.</p></div></div></div></div></div></div><div class="contact-callout_component"><div class="padding-global"><div class="container-large"><div class="contact-callout-content"><div class="text-style-spaced"><h3 class="heading-style-h3"><strong class="contact-callout-boldtext">Excited about the vision?</strong> Contact us today!</h3></div><a href="/contact" class="button w-button">Contact Us</a></div></div></div></div></main><footer class="footer_component"><div><div class="container-large"><div class="footer-content"><div class="footer-logo"><a href="/" class="nav_logo-wrapper w-inline-block"><img src="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/6463a2b3aca734e665ad68fa_Manifold%20Bio%20Logo.svg" loading="lazy" alt="Manifold Bio logo" class="nav_logo"/></a></div><div id="w-node-_6802c733-3d30-2945-ce21-98d84fff32c9-4fff32c2" class="footer_nav"><div class="footer_nav_item"><a href="/about" class="footer_nav_link">About</a></div><div class="footer_nav_item"><a href="/platform" aria-current="page" class="footer_nav_link w--current">Platform</a></div><div class="footer_nav_item"><a href="/news" class="footer_nav_link">News</a></div><div class="footer_nav_item"><a href="/careers" class="footer_nav_link">Careers</a></div><div class="footer_nav_item"><a href="/contact" class="footer_nav_link">Contact Us</a></div></div><div id="w-node-_6802c733-3d30-2945-ce21-98d84fff32dc-4fff32c2" class="footer-social-legal"><div>Follow Us</div><div class="footer_social-icons"><a href="https://www.linkedin.com/company/manifold-bio/" target="_blank" class="footer_social-link w-inline-block"><div class="w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="32" height="32" fill="currentColor" viewBox="0 0 32 32"> <path d="M29.714 0H2.28C1.02 0 0 1.036 0 2.307v27.386C0 30.964 1.021 32 2.279 32h27.435C30.971 32 32 30.964 32 29.693V2.307C32 1.036 30.971 0 29.714 0ZM9.671 27.429H4.93V12.157h4.75V27.43h-.01ZM7.3 10.07a2.751 2.751 0 0 1 0-5.5 2.756 2.756 0 0 1 2.75 2.75 2.747 2.747 0 0 1-2.75 2.75Zm20.15 17.36h-4.743V20c0-1.771-.036-4.05-2.464-4.05-2.472 0-2.85 1.929-2.85 3.921v7.558H12.65V12.157h4.55v2.086h.064c.636-1.2 2.186-2.464 4.493-2.464 4.8 0 5.693 3.164 5.693 7.278v8.372Z"/> </svg></div></a><a href="https://twitter.com/manifoldbio" target="_blank" class="footer_social-link w-inline-block"><div class="w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="32" height="32" fill="currentColor" viewBox="0 0 32 32"> <path d="M10.063 29c12.076 0 18.681-10.003 18.681-18.684 0-.285 0-.567-.02-.849A13.361 13.361 0 0 0 32 6.067a13.09 13.09 0 0 1-3.771 1.034 6.586 6.586 0 0 0 2.886-3.628 13.144 13.144 0 0 1-4.169 1.594 6.57 6.57 0 0 0-11.186 5.985 18.635 18.635 0 0 1-13.533-6.86 6.573 6.573 0 0 0 2.033 8.765 6.51 6.51 0 0 1-2.98-.822v.08a6.57 6.57 0 0 0 5.267 6.438 6.546 6.546 0 0 1-2.965.113 6.577 6.577 0 0 0 6.135 4.561 13.17 13.17 0 0 1-8.154 2.817c-.522 0-1.044-.031-1.563-.092A18.586 18.586 0 0 0 10.063 29"/> </svg></div></a><a href="https://www.instagram.com/manifoldbio/" target="_blank" class="footer_social-link w-inline-block"><div class="w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="32" height="32" fill="currentColor" viewBox="0 0 32 32"> <path d="M16.004 7.796A8.19 8.19 0 0 0 7.8 16a8.19 8.19 0 0 0 8.203 8.204A8.19 8.19 0 0 0 24.206 16a8.19 8.19 0 0 0-8.202-8.204Zm0 13.538A5.343 5.343 0 0 1 10.67 16a5.338 5.338 0 0 1 5.333-5.334A5.338 5.338 0 0 1 21.336 16a5.343 5.343 0 0 1-5.332 5.334ZM26.454 7.46a1.909 1.909 0 0 1-1.912 1.914 1.914 1.914 0 1 1 1.913-1.914Zm5.434 1.942c-.122-2.563-.707-4.834-2.585-6.705C27.433.827 25.163.241 22.6.112c-2.642-.15-10.559-.15-13.2 0C6.844.234 4.574.82 2.697 2.69.819 4.561.24 6.832.112 9.395c-.15 2.642-.15 10.56 0 13.203.122 2.563.707 4.834 2.585 6.705 1.877 1.87 4.14 2.456 6.703 2.584 2.641.15 10.559.15 13.2 0 2.563-.12 4.833-.706 6.703-2.584 1.87-1.871 2.456-4.142 2.585-6.705.15-2.642.15-10.554 0-13.196Zm-3.413 16.03a5.4 5.4 0 0 1-3.041 3.042c-2.106.836-7.103.643-9.43.643-2.328 0-7.332.186-9.43-.643a5.4 5.4 0 0 1-3.042-3.041c-.835-2.107-.643-7.105-.643-9.433 0-2.328-.185-7.333.643-9.433a5.4 5.4 0 0 1 3.041-3.041c2.106-.836 7.103-.643 9.43-.643 2.328 0 7.332-.186 9.431.643a5.4 5.4 0 0 1 3.041 3.041c.835 2.107.643 7.105.643 9.433 0 2.328.192 7.333-.643 9.433Z"/> </svg></div></a></div><div>© Manifold Biotechnologies, Inc.</div></div></div></div></div></footer></div><script src="https://d3e54v103j8qbb.cloudfront.net/js/jquery-3.5.1.min.dc5e7f18c8.js?site=6463a2b3aca734e665ad6854" type="text/javascript" integrity="sha256-9/aliU8dGd2tb6OSsuzixeV4y/faTqgFtohetphbbj0=" crossorigin="anonymous"></script><script src="https://cdn.prod.website-files.com/6463a2b3aca734e665ad6854/js/webflow.ba64b7d2e.js" type="text/javascript"></script></body></html>