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Webinar: Light scattering solutions for multi-attribute quantification of mRNA-lipid nanoparticle therapeutics by CII Webinars
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Learning Objectives: • Improving data sharing & collaboration in registries • What is federated learning? • How is SymetryML’s federated learning 2.0 different/better? • Efficiently building and scaling machine learning models for enhanced analysis <a href="http://www.cambridgeinnovationinstitute.com/Privacy-Policy/?_ga=2.224260376.225289126.1652994964-383270938.1652994964">Privacy Policy</a>"> <meta name="msvalidate.01" content="7FB67E680F127E1BBF8AF2977231BE73" /> <meta property="og:title" content="Light scattering solutions for multi-attribute quantification of mRNA-lipid nanoparticle therapeutics"/> <meta property="og:description" content="<i>Sponsored by UBC & SymetryML</i> The rare disease registry landscape consists of small, disjointed data sets stored across different national registries and localized consortia. These data silos, coupled with strict data privacy regulations, limit the collaboration that is needed by researchers to enhance analysis. 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quantification of mRNA-lipid nanoparticle therapeutics</h1></div> <div class="conf-creation-after-time js-conference-start-time2" style="display: none">Tuesday, May 7, 2024 · 11:00 a.m. · Eastern Time (US & Canada) <span style="float: right"></span> </div> </div> <div class="conf-creation-landing-left-border"> <div class="js-purpose-section " style="padding-top: 0"> <div class=""> <div class="conf-creation-landing-about-title">About This Webinar</div> <div class=""> <div class="conf-creation-landing-about-textbox template-edit-area js-purpose-content " style="" field-name="purpose"> <p> <i>Sponsored by Waters|Wyatt Technology</i><br /><br />Light scattering techniques deliver multi-attribute quantification (MAQ) of mRNA and lipid nanoparticle-formulated mRNA and can play a key role in product and process development as well as quality control of mRNA-LNP therapeutics. Specifically, multi-angle light scattering (MALS) coupled to separation by field-flow fractionation (FFF) or size-exclusion chromatography (SEC) provides high-resolution quantification of several mRNA and LNP attributes including size distribution, physical stability, LNP number concentration, morphology, and mRNA and lipid concentration. The method can also be applied to evaluate how these attributes are affected by preparation, formulation, and storage conditions. In addition to high-resolution MAQ by SEC/FFF-MALS, dynamic light scattering (DLS) and electrophoretic light scattering (ELS) can be used for rapid, automatable batch measurements of particle size and concentration, polydispersity, and zeta potential, enabling rapid screening of the impact of different ions, ionic strength, pH, temperature and other parameters on the biophysical properties and stability of mRNA and LNP-mRNA.<br /><br />Learning Objectives: <br />• How to bring multi-attribute quantification to LNP and mRNA characterization <br />• Considerations for technology selection for LNP and mRNA <br />• What rapid screening light scattering techniques exists today for LNP and mRNA formulation optimization<br /><br /><a href="http://www.cambridgeinnovationinstitute.com/Privacy-Policy/?_ga=2.224260376.225289126.1652994964-383270938.1652994964">Privacy Policy</a> </p> </div> </div></div></div> <div class="conf-creation-landing-about-type show_additional_info_right" style="display: block"> <span>Who can view:</span> Everyone </div> <div class="conf-creation-landing-about-type show_additional_info_right" style="display: block"> <span>Webinar Price:</span> Free </div> <div class="conf-creation-landing-about-type show_webinar_id_right show_additional_info_right" style="display: block"> <span>Webinar ID:</span> cc882b70a5fc </div> </div> <!-- presenter --> <div class="conf-creation-landing-left-border"> <div class="conf-creation-landing-about-title custom-font-sub-title">Featured Presenters</div> <div id="template-presenter-list"> <div class="conf-creation-landing-about-community" id="presenter-profile-id-60f32ce21fe0"> <div class="conf-creation-landing-about-user-left"> <div class="conf-creation-landing-user-img"> <img alt="Webinar hosting presenter " src="https://d5ln38p3754yc.cloudfront.net/presenters/34351268/medium/1711544841-58e12b790dfc595f.jpg?1711544841" /> </div> </div> <div class="conf-creation-landing-about-community-right"> <div class="conf-creation-landing-about-community-right-in"> <div class="conf-creation-landing-about-community-name custom-font-sub-title"><h3> <a href="https://www.bigmarker.com/conferences/show_presenter?presenter_id=60f32ce21fe0" id="2b314292-1272-4f82-9bcf-fffe97f910d9" rel="modal:open"> Martin Kurnik, Ph.D. </a> </h3></div> <div class="conf-creation-presenter-box-subname custom-font-sub-title">Application Scientist, Analytical Sciences, Waters|Wyatt Technology</div> <div class="conf-creation-landing-about-user-detail"> Martin Kurnik joined the Analytical Sciences team at Waters | Wyatt Technology in 2021, where he helps customers identify and develop the best solutions for their analytical needs. As an application scientist, Martin leverages his expertise in multi-angle light scattering and dynamic light scattering as well as a wide range of other leading techniques for biomolecular characterization. His postdoctoral research in protein folding and misfolding biophysics focused on understanding and preventing misfolding in bulk solution and on artificial surfaces used in medicine and biotechnology, and he has also developed protein- and aptamer-based electrochemical biosensors for continuous real-time measurements in vitro and in vivo. Martin received his M.Sc. in Chemistry and Ph.D. in Biochemistry from Stockholm University, Sweden. </div> <div class="conf-creation-landing-about-community-link"> <a href="https://www.bigmarker.com/conferences/show_presenter?presenter_id=60f32ce21fe0" id="38957bea-8b6d-476f-a90c-210ba1868e15" rel="modal:open">VIEW PROFILE</a> </div> <div class="presenter_social"> <ul class="nrp-host-channel-share"> </ul> </div> </div> </div> </div> </div> </div> <!-- /presenter --> <!-- hosted by --> <div class="conf-creation-landing-left-border show_hosted_by_right" style="padding: 24px; "> <div class="conf-creation-landing-about-title custom-font-sub-title" style="padding-bottom: 0px;">Hosted By</div> <div class="conf-creation-landing-about-community" style="padding: 8px 0 0 0;"> <div class="conf-creation-landing-about-community-left"> <div class="conf-creation-landing-community-img"> <a href="/ciiwebinars"><img alt="CII Webinars webinar platform hosts Light scattering solutions for multi-attribute quantification of mRNA-lipid nanoparticle therapeutics" src="https://d5ln38p3754yc.cloudfront.net/club_icons/343359/medium/1645023681-eb4be703b92e98bb.jpg?1645023681" /></a> </div> </div> <div class="conf-creation-landing-about-community-right"> <div class="conf-creation-landing-about-community-right-in"> <div class="conf-creation-landing-about-community-name"><h2><a href="/ciiwebinars">CII Webinars</a></h2></div> <div class="conf-creation-landing-about-community-detail"></div> <div class="conf-creation-landing-about-community-link"> <a href="/communities/ciiwebinars/about">VIEW CHANNEL</a> <a href="/messages/new?recipient_club_profile_id=e37ed29d97e9" id="contact_host_by" rel="modal:open"> CONTACT </a> </div> </div> </div> </div> </div> <!-- /hosted by --> <div class="conf-creation-landing-left-border can_view_attended_right"> <div class="conf-creation-landing-about-title custom-font-sub-title"> Attended (106) </div> </div> </div> </div> <div class="conf-creation-landing-right"> <div class="conf-creation-landing-left-border"> <div class="conf-creation-landing-about-title custom-font-sub-title">Recommended</div> <ul class="conf-creation-after-recommended recommended-webinar-show-position-1"> </ul> </div> </div> </div> </div> </div> </div> <input id="auto_play_recording" name="auto_play_recording" type="hidden" /> </div> </div> </div> <div class="template-5-footer clear"> <div class="template-5-footer-link" id="channel-template-name"> <a href="/ciiwebinars" class="theme-link-custom-color">All CII Webinars webinars</a> </div> <div class="template-5-footer-copyright">Powered by BigMarker</div> </div> </div> </div> </div> </div> </div> <a href="/conferences/cc882b70a5fc/conference_registrations/guest_access" data-maxWidth="480px" id="js-enter-full-name" rel="modal:open"></a> <script src="https://d5spd9ylw8dyc.cloudfront.net/assets/moment.min-7aca858b94515593779841359238a14d.js" type="text/javascript"></script> <script src="https://d5spd9ylw8dyc.cloudfront.net/assets/moment-timezone-with-data.min-28b2af1db133cca12d0bc375e5b3a659.js" type="text/javascript"></script> <script src="https://d5spd9ylw8dyc.cloudfront.net/assets/lazyload-59ca3f8c871c504dbb93a2641125a70c.js" type="text/javascript"></script> <script src="https://checkout.stripe.com/checkout.js"></script> <style type="text/css" media="all"> .header-user-out-img { display: block; 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